Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

TRPC4 ITPR3

6.94e-0514182GO:0070679
GeneOntologyMolecularFunctioncalmodulin binding

MYO6 SPTAN1 EEA1

1.08e-03230183GO:0005516
GeneOntologyMolecularFunctionphospholipid binding

MAP1B SYT4 EEA1 ITPR3

1.26e-03548184GO:0005543
GeneOntologyBiologicalProcessregulation of synaptic plasticity

MAP1B MYO6 SYT4 ITPR3

1.04e-04293184GO:0048167
GeneOntologyBiologicalProcessglutamate secretion

MYO6 SYT4

5.50e-0440182GO:0014047
GeneOntologyBiologicalProcessamino acid transport

MYO6 SYT4 TRPC4

6.11e-04195183GO:0006865
GeneOntologyBiologicalProcessneuron projection extension

MAP1B SYT4 NRP1

7.27e-04207183GO:1990138
GeneOntologyBiologicalProcesspositive regulation of cell growth

MAP1B SYT4 NRP1

7.90e-04213183GO:0030307
GeneOntologyBiologicalProcessanterograde trans-synaptic signaling

MAP1B MYO6 SYT4 EEA1 ITPR3

9.71e-04931185GO:0098916
GeneOntologyBiologicalProcesschemical synaptic transmission

MAP1B MYO6 SYT4 EEA1 ITPR3

9.71e-04931185GO:0007268
GeneOntologyBiologicalProcesstrans-synaptic signaling

MAP1B MYO6 SYT4 EEA1 ITPR3

1.01e-03939185GO:0099537
GeneOntologyBiologicalProcesspositive regulation of axon extension

MAP1B NRP1

1.04e-0355182GO:0045773
GeneOntologyBiologicalProcesspositive regulation of developmental growth

MAP1B SYT4 NRP1

1.09e-03238183GO:0048639
GeneOntologyBiologicalProcesssynaptic signaling

MAP1B MYO6 SYT4 EEA1 ITPR3

1.20e-03976185GO:0099536
GeneOntologyBiologicalProcessdevelopmental growth involved in morphogenesis

MAP1B SYT4 NRP1

2.09e-03299183GO:0060560
GeneOntologyBiologicalProcessdevelopmental cell growth

MAP1B SYT4 NRP1

2.13e-03301183GO:0048588
GeneOntologyBiologicalProcessmodulation of chemical synaptic transmission

MAP1B MYO6 SYT4 ITPR3

2.26e-03663184GO:0050804
GeneOntologyBiologicalProcessregulation of trans-synaptic signaling

MAP1B MYO6 SYT4 ITPR3

2.27e-03664184GO:0099177
GeneOntologyBiologicalProcessacidic amino acid transport

MYO6 SYT4

2.40e-0384182GO:0015800
GeneOntologyBiologicalProcessnegative regulation of protein depolymerization

MAP1B SPTAN1

2.69e-0389182GO:1901880
GeneOntologyCellularComponentchromosome, centromeric region

PHF10 CBX5 SMC1B CFDP1 HELLS

2.88e-06276185GO:0000775
GeneOntologyCellularComponentchromosomal region

PHF10 CBX5 SMC1B CFDP1 HELLS

2.23e-05421185GO:0098687
GeneOntologyCellularComponentglutamatergic synapse

MAP1B MYO6 SYT4 SPTAN1 EEA1 NRP1

4.34e-05817186GO:0098978
GeneOntologyCellularComponentaxon

MAP1B MYO6 SYT4 SPTAN1 EEA1 NRP1

7.04e-05891186GO:0030424
GeneOntologyCellularComponentcondensed chromosome

PHF10 CBX5 SMC1B CFDP1

1.19e-04307184GO:0000793
GeneOntologyCellularComponentpostsynapse

MAP1B MYO6 SYT4 SPTAN1 EEA1 NRP1

1.47e-041018186GO:0098794
GeneOntologyCellularComponentpericentric heterochromatin

CBX5 HELLS

3.42e-0432182GO:0005721
GeneOntologyCellularComponentkinetochore

PHF10 CBX5 CFDP1

4.73e-04181183GO:0000776
GeneOntologyCellularComponentneuronal cell body

MAP1B MYO6 SYT4 NRP1 ITPR3

5.58e-04835185GO:0043025
GeneOntologyCellularComponentcondensed chromosome, centromeric region

PHF10 CBX5 CFDP1

5.71e-04193183GO:0000779
GeneOntologyCellularComponentcell body

MAP1B MYO6 SYT4 NRP1 ITPR3

9.05e-04929185GO:0044297
GeneOntologyCellularComponenthistone deacetylase complex

CBX5 CFDP1

2.40e-0385182GO:0000118
GeneOntologyCellularComponentsupramolecular fiber

MAP1B MYO6 SPTAN1 CFAP210 NRP1

2.62e-031179185GO:0099512
GeneOntologyCellularComponentmain axon

MAP1B SPTAN1

2.62e-0389182GO:0044304
GeneOntologyCellularComponentsupramolecular polymer

MAP1B MYO6 SPTAN1 CFAP210 NRP1

2.69e-031187185GO:0099081
GeneOntologyCellularComponentSWI/SNF superfamily-type complex

PHF10 CFDP1

3.04e-0396182GO:0070603
GeneOntologyCellularComponentsomatodendritic compartment

MAP1B MYO6 SYT4 NRP1 ITPR3

3.12e-031228185GO:0036477
GeneOntologyCellularComponentheterochromatin

CBX5 HELLS

3.36e-03101182GO:0000792
GeneOntologyCellularComponentcell cortex

MYO6 SPTAN1 TRPC4

3.71e-03371183GO:0005938
GeneOntologyCellularComponentcortical cytoskeleton

SPTAN1 TRPC4

5.42e-03129182GO:0030863
GeneOntologyCellularComponentATPase complex

PHF10 CFDP1

5.42e-03129182GO:1904949
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

MAP1B MYO6 CFAP210 NRP1

6.42e-03899184GO:0099513
GeneOntologyCellularComponentperinuclear region of cytoplasm

MAP1B MYO6 SYT4 ITPR3

7.33e-03934184GO:0048471
GeneOntologyCellularComponentbrush border

MYO6 ITPR3

7.45e-03152182GO:0005903
GeneOntologyCellularComponentSchaffer collateral - CA1 synapse

MYO6 EEA1

7.73e-03155182GO:0098685
MousePhenoimpaired social transmission of food preference

SYT4 ITPR3

5.88e-0511152MP:0002969
MousePhenoimpaired discrimination learning

SYT4 ITPR3

9.71e-0514152MP:0012296
DomainIon_trans_dom

TRPC4 ITPR3

4.73e-03114172IPR005821
DomainIon_trans

TRPC4 ITPR3

4.73e-03114172PF00520
DomainZnf_FYVE_PHD

PHF10 EEA1

7.74e-03147172IPR011011
Pubmed

Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.

MAP1B CBX5 SPTAN1 EEA1 HELLS

7.58e-0821918531353912
Pubmed

Cdx2 regulates endo-lysosomal function and epithelial cell polarity.

MYO6 SPTAN1 EEA1

6.29e-073318320551175
Pubmed

Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.

TRPC4 ITPR3

1.52e-06418211163362
Pubmed

GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBP.

MYO6 EEA1

3.79e-06618215975910
Pubmed

Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells.

TRPC4 ITPR3

3.79e-06618217416589
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

MAP1B CBX5 EEA1 NRP1 HELLS ITPR3

8.80e-06102418624711643
Pubmed

Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels.

TRPC4 ITPR3

9.09e-06918211290752
Pubmed

Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea.

MYO6 NRP1

9.09e-06918229059194
Pubmed

USP9X-mediated NRP1 deubiquitination promotes liver fibrosis by activating hepatic stellate cells.

SPTAN1 NRP1

1.14e-051018236653359
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

CCDC14 MAP1B CBX5 SPTAN1 HELLS

1.52e-0564518525281560
Pubmed

alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.

SPTAN1 TRPC4

1.97e-051318218796539
Pubmed

ELMOD1 Stimulates ARF6-GTP Hydrolysis to Stabilize Apical Structures in Developing Vestibular Hair Cells.

MYO6 EEA1

1.97e-051318229222402
Pubmed

Cochlear hair cell innervation is dependent on a modulatory function of Semaphorin-3A.

MYO6 NRP1

2.29e-051418236284453
Pubmed

Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation.

CBX5 SMC1B

2.29e-051418221875947
Pubmed

Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN.

MAP1B MYO6 CBX5 SPTAN1

2.30e-0533418430425250
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

MAP1B MYO6 PHF10 SPTAN1 HELLS

2.64e-0572418536232890
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

MAP1B CBX5 SPTAN1 EEA1

4.38e-0539418427248496
Pubmed

The small GTPase Rac1 regulates auditory hair cell morphogenesis.

MYO6 SPTAN1

6.36e-052318220016102
Pubmed

An Interaction Landscape of Ubiquitin Signaling.

CCDC14 MYO6 SPTAN1 ITPR3

9.48e-0548118428190767
Pubmed

mSWI/SNF (BAF) Complexes Are Indispensable for the Neurogenesis and Development of Embryonic Olfactory Epithelium.

PHF10 NRP1

9.49e-052818227611684
Pubmed

Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.

PHF10 CBX5 SPTAN1

1.09e-0418218326527279
Pubmed

Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence.

MAP1B NRP1

1.09e-043018219054571
Pubmed

Discrete gene sets depend on POU domain transcription factor Brn3b/Brn-3.2/POU4f2 for their expression in the mouse embryonic retina.

SYT4 NRP1

1.24e-043218214973295
Pubmed

Goofy coordinates the acuity of olfactory signaling.

EEA1 NRP1

1.41e-043418223926254
Pubmed

ABCE1 is a highly conserved RNA silencing suppressor.

MAP1B MYO6 CBX5

1.52e-0420418325659154
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

TRPC4 ITPR3

1.76e-043818230786075
Pubmed

Etv1 Controls the Establishment of Non-overlapping Motor Innervation of Neighboring Facial Muscles during Development.

GPR149 NRP1

1.76e-043818231597102
Pubmed

Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.

MAP1B MYO6 SPTAN1 ITPR3

2.60e-0462618433644029
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

MYO6 CBX5 SPTAN1 ITPR3

3.18e-0466018432780723
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

MYO6 CBX5 SPTAN1 HELLS ITPR3

3.41e-04124718527684187
Pubmed

RNF38 suppress growth and metastasis via ubiquitination of ACTN4 in nasopharyngeal carcinoma.

MYO6 SPTAN1

4.70e-046218235568845
Pubmed

DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis.

MYO6 SPTAN1

4.85e-046318237052853
InteractionWDR76 interactions

MAP1B CBX5 SPTAN1 EEA1 HELLS

1.69e-05383185int:WDR76
InteractionL3MBTL2 interactions

PHF10 CBX5 HELLS ITPR3

4.54e-05231184int:L3MBTL2
InteractionFURIN interactions

MYO6 CBX5 SPTAN1 HELLS

6.66e-05255184int:FURIN
InteractionLRRC49 interactions

CCDC14 MYO6 EEA1

1.03e-04104183int:LRRC49
InteractionZFYVE16 interactions

MYO6 SPTAN1 EEA1

1.03e-04104183int:ZFYVE16
InteractionPCDH19 interactions

SPTAN1 NRP1

1.72e-0422182int:PCDH19
InteractionTRPC4 interactions

TRPC4 ITPR3

1.89e-0423182int:TRPC4
InteractionZNF333 interactions

CBX5 SPTAN1

2.06e-0424182int:ZNF333
InteractionTRPC5 interactions

TRPC4 ITPR3

2.06e-0424182int:TRPC5
InteractionCCDC8 interactions

MAP1B EEA1 NRP1 HELLS ITPR3

2.17e-04656185int:CCDC8
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

MAP1B ITPR3

7.23e-03181132694
CoexpressionGSE17186_BLOOD_VS_CORD_BLOOD_CD21LOW_TRANSITIONAL_BCELL_DN

PHF10 EEA1 NRP1 HELLS

9.26e-06200184M7196
CoexpressionAIZARANI_LIVER_C9_LSECS_1

MAP1B MYO6 PHF10 NRP1

4.77e-05304184M39113
CoexpressionGAO_LARGE_INTESTINE_ADULT_CA_ENTEROENDOCRINE_CELLS

MAP1B SYT4 CCDC74A NRP1

5.28e-05312184M39161
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC14 SMC1B CFAP210 CCDC74A HELLS

7.96e-091801850c146e80d55d18b6988dd21b1da635801bd3140c
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC14 SMC1B CFAP210 CCDC74A HELLS

7.96e-09180185e9af22beae2f3c7fe213b4e19df84abfd2453433
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC14 SMC1B CFAP210 CCDC74A HELLS

7.96e-0918018511455ba704ac73f69b474845136cfecec6a88349
ToppCellNS-critical-d_07-13-Epithelial-FOXN4+|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CCDC14 PHF10 HELLS ITPR3

9.00e-071901847be0f2ff86ca8500a43e0d44e5e292530f9ba0bb
ToppCellmoderate-Epithelial-FOXN4+|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CCDC14 PHF10 CCDC74A HELLS

9.78e-071941845dffa578149104dda33774361e9e77b227b5f1ce
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn|World / Primary Cells by Cluster

MAP1B SYT4 SPTAN1 NRP1

1.02e-061961849401bd84798f0ea3e986e94135a9e1dc5643330f
ToppCellcritical-Epithelial-FOXN4+|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CCDC14 PHF10 CBX5 HELLS

1.06e-061981846b160b3d6a2c1b1641c2c7dcec1a7ef38411fec9
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW19-Neuronal-Neurons|GW19 / Sample Type, Dataset, Time_group, and Cell type.

MAP1B SYT4 SPTAN1 NRP1

1.10e-06200184b9538eb33ac86384e7e289a5a82fac4d56a7b9c2
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Cortical_neuron|GW23 / Sample Type, Dataset, Time_group, and Cell type.

MAP1B SYT4 SPTAN1 NRP1

1.10e-062001847bba2ff09349c8db3d1ccf53520b12cbf7b0abac
ToppCell3'_v3-Lung-Lymphocytic_B-ABC_aged-B_memory|Lung / Manually curated celltypes from each tissue

MAP1B CCDC74A HELLS

3.73e-051641837766900740f67dbbe3c4d90fbfdcc1665cee6515
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MAP1B TRPC4 NRP1

4.00e-05168183d19a115365c5415e51c039718d7669de788fcf33
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MAP1B TRPC4 CFAP210

4.08e-051691838bca402e144819cb9a8d431d6bf9429be2fff6d6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAP1B TRPC4 HELLS

4.22e-05171183b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAP1B TRPC4 HELLS

4.22e-05171183b0373ed8283ee1792b6a490bff93906546978593
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAP1B TRPC4 NRP1

4.29e-05172183107417cfab7775bc1f80807115047abfb50b7a7e
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC14 CCDC74A HELLS

4.45e-05174183c2f8c59fca5f1ff6ffa6dc8cfce62da4b19fe9b3
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC14 CCDC74A HELLS

4.45e-0517418384024c04b0ce9f7068677d2d99ede56882b7dbd2
ToppCellfacs-Lung-nan-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYT4 HELLS ITPR3

4.45e-051741831c073177c1753e3b91ef8fd9e95230a1d13c82f3
ToppCellfacs-Lung-nan-3m-Lymphocytic-CD8+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYT4 HELLS ITPR3

4.45e-051741835491ad5c144baf2ef9b1c58eb720c872d14feb15
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC14 CCDC74A HELLS

4.45e-051741830227fea1678baa9168bd47c3b4aacb2592bb5867
ToppCellNS-critical-d_16-33-Epithelial-FOXN4+|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CCDC14 CCDC74A HELLS

4.60e-051761837cf1a06ceee1ec06532f44c729c31b4d58e5ea49
ToppCellCiliated_cells-A-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

MAP1B CFAP210 CCDC74A

4.92e-05180183d9be152773fe9f2160edad9246fa03c03afeafd6
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAP1B TRPC4 NRP1

5.08e-0518218344764676ed3f51ba171ce63f669390392fa50a43
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAP1B TRPC4 NRP1

5.08e-05182183d82f59a3f930a840dde27dc6ab024f227a26d446
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MAP1B TRPC4 NRP1

5.25e-05184183e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCellCiliated_cells-A-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

MAP1B CFAP210 CCDC74A

5.33e-05185183d77ca57b02125a3a57a37f4aed20c89803b7d551
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAP1B SYT4 CCDC74A

5.42e-05186183d1d01ce46e62944aa9864eda47e8401b5f0d2bdc
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAP1B SYT4 GPR149

5.42e-0518618318fd311252299d6d30ddb32002ed069056108206
ToppCellCOVID-19-kidney-Fibroblast-1|COVID-19 / Disease (COVID-19 only), tissue and cell type

MAP1B TRPC4 NRP1

5.51e-0518718376bfe8c42430a230a8bdf299575c444fb7780f24
ToppCellCiliated_cells-B-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

MAP1B CFAP210 CCDC74A

5.59e-05188183606907c865bd2f11bb6474932716550f7723d858
ToppCelltumor_Lung-Epithelial_cells-tS3|tumor_Lung / Location, Cell class and cell subclass

MAP1B CFAP210 CCDC74A

5.59e-0518818326326b4e298e33f9ba393fc632238aa8c54b1ea3
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAP1B NRP1 ITPR3

5.68e-051891839da012fdfa9a8d488cab710a463a1d70e89f990c
ToppCellEpithelial_cells-Ciliated_cells-B|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

MAP1B CFAP210 CCDC74A

5.77e-05190183426a4806f6e39d4d57c6746609d30bb3ca62df7d
ToppCellCOVID-19-Heart-EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

MAP1B TRPC4 NRP1

5.77e-05190183a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCellEpithelial_cells-Ciliated_cells-A|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

MAP1B CFAP210 CCDC74A

5.77e-05190183549d813a8f23b175875e53347928941f143e236c
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC14 CCDC74A HELLS

5.77e-051901830adb24dafa077156bbc73a8d8cbf3d9eeb6e08df
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC14 CCDC74A HELLS

5.77e-0519018305455775845f4ded5c27e7b83242078d23162aaf
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Ciliated_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

MAP1B CFAP210 CCDC74A

5.77e-05190183a90a38fccdbf75a286b4d258fc54920c02b282f7
ToppCellBAL-Control-Epithelial-Epithelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MAP1B CFAP210 CCDC74A

5.86e-05191183df8a1a6e78aa0cb941b94cb676bd6891d79f3687
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MAP1B CFAP210 CCDC74A

5.86e-051911837b5da29109aa28768c67653a1bc0f385c2d2269b
ToppCellBAL-Control-Epithelial|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

MAP1B CFAP210 CCDC74A

5.86e-051911839f19098f260d5542aa8ba7eb6f91b44d0db6e0a4
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MAP1B CFAP210 CCDC74A

5.86e-05191183fa9f8b50bfc7911c858bc2f9dcd204873d97ac61
ToppCellControl-Epithelial|Control / Disease group,lineage and cell class （2021.01.30）

MAP1B CFAP210 CCDC74A

5.86e-05191183b78547dae8328244a47c83346447bdd787efbcae
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MAP1B CFAP210 CCDC74A

5.86e-05191183b4e335e798c9617356b8e24412f9270c42dce656
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MAP1B CFAP210 CCDC74A

5.86e-05191183c4b223b33c020a064f576711a3d700eb60a2d737
ToppCellBAL-Control-Epithelial-Epithelial|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MAP1B CFAP210 CCDC74A

5.86e-05191183c50d6a1a6209ed4157f7c00fc24d4ecb43790f44
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAP1B NRP1 ITPR3

5.86e-051911833307dbccadb09c62b0e1c0235ec89bb294d748c3
ToppCellBAL-Control-Epithelial|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MAP1B CFAP210 CCDC74A

5.86e-051911835129f778a9283bfac4ff322c21c5ca71da4b7174
ToppCellControl-Epithelial-Ciliated|Control / Disease group,lineage and cell class （2021.01.30）

MAP1B CFAP210 CCDC74A

5.86e-05191183cdc08e95a0c8f5c7a8d01b6bbaafdb54ef2f0d12
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MAP1B TRPC4 NRP1

5.96e-05192183bc84b9ce01b4d826a682842ab8a395dac9b91183
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MAP1B TRPC4 NRP1

5.96e-051921830ab1176cfbb0de8dd1f22c6e2c41265cf6c10ee1
ToppCellBronchial_Biopsy-Epithelial-Ciliated_1|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

MAP1B CFAP210 CCDC74A

6.05e-051931830b62a6ddd7c42efd9f39781971d1438501e1fa8d
ToppCellLAM-Epithelial-AirwayEpi|Epithelial / Condition, Lineage and Cell class

MAP1B CFAP210 CCDC74A

6.05e-05193183f2672d2c495ee12c3b7d132452bde581fa5a7856
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MAP1B TRPC4 NRP1

6.05e-05193183f1199518c3626fd29bfce65070dd21a660671213
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Newborn-22|World / Primary Cells by Cluster

SYT4 SPTAN1 NRP1

6.05e-051931833b927d4b8ecb21a408424ef91a23746c21741f49
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CCDC14 CBX5 HELLS

6.14e-051941837a66bd7d4fc9c6db861cedd2487f241e406869d1
ToppCell10x3'2.3-week_17-19-Endothelial-stroma-immature_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MAP1B MYO6 NRP1

6.14e-05194183bf8e78d53802ac758be1c3db833779c26a94e1d5
ToppCellmoderate-Epithelial-FOXN4+|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CCDC14 PHF10 HELLS

6.14e-05194183dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MAP1B EEA1 CFDP1

6.14e-051941838985095f291c1b54e45f4edece49aa26e8c8b732
ToppCellE16.5|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CBX5 CFDP1 HELLS

6.14e-051941838a48f596cf1ca43718b9db661305c150e459f8d4
ToppCellCOVID-19-kidney-Fibroblast-2|COVID-19 / Disease (COVID-19 only), tissue and cell type

MAP1B TRPC4 NRP1

6.24e-051951833d62ce1c696f47d4d7eb0c5bb0eec2c24b122bb2
ToppCell(4)_B_Hypermutation|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

CBX5 SMC1B HELLS

6.24e-0519518354d2acaff6be6b5604591bdbd7d769ac3e74f223
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CCDC14 CBX5 HELLS

6.43e-0519718341bdea47b9b1f6415a866a515d1535ea942fdede
ToppCellH1299-infected-SARSCoV2|infected / Cell line, Condition and Strain

MAP1B MYO6 CFDP1

6.43e-051971830fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell10x3'2.3-week_17-19-Endothelial-stroma-tip_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MAP1B MYO6 NRP1

6.43e-05197183b212ff28ca2d1fea4140f186ab90941bdca21249
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-DN_to_DP_transition,_dividing_(more_DN)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CBX5 NRP1 HELLS

6.43e-05197183d9978aaa476b57144b0561f535ff1dd886c7512b
ToppCell10x3'2.3-week_17-19-Endothelial-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MAP1B MYO6 NRP1

6.52e-051981831e83bec16dcd60460422625f89952ff506d6be51
ToppCell10x3'2.3-week_17-19-Endothelial|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MAP1B MYO6 NRP1

6.52e-051981832630a7a6e56febe5c0b0bde70dd7292fa1650c47
ToppCell(11)_FOXN4+|World / shred by cell type by condition

CCDC14 CCDC74A HELLS

6.52e-05198183516b1acdf997dd8debc3dca066519366e507b414
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

MAP1B NRP1 ITPR3

6.62e-0519918385bb28369e0568b7b3bda095722102fc793f60ef
ToppCellInfluenza_Severe-T/NK_proliferative|Influenza_Severe / Disease group and Cell class

CBX5 SMC1B HELLS

6.62e-051991832508c55f9ffe17b694c70f1283f41ad4a8e83c00
ToppCellNeuron|World / Primary Cells by Cluster

MAP1B SYT4 SPTAN1

6.62e-051991831f8104fd92f04690b41d9d07ac08dc59d76bb97d
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal-Neurons|GW16 / Sample Type, Dataset, Time_group, and Cell type.

SYT4 SPTAN1 NRP1

6.62e-05199183ae575ed7582f2a4218f6cbcbf5f7f0ce7a5bc26b
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-Neuronal-PNs|1_mon / Sample Type, Dataset, Time_group, and Cell type.

MAP1B MYO6 SYT4

6.62e-05199183c8aaf6ebd1cb6f6e59fdffeb81f9a3c921cc592a
ToppCellNeuron-Postmitotic|World / Primary Cells by Cluster

MAP1B SYT4 SPTAN1

6.62e-051991831973527f8a7d4c6490d75c0d0ea153688166a08b
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal|GW26 / Sample Type, Dataset, Time_group, and Cell type.

MAP1B SYT4 SPTAN1

6.62e-05199183a255484ba77bd2741a541da278efc8cf4abbe570
ToppCellNeuron-Postmitotic-Excitatory_Neuron_|World / Primary Cells by Cluster

MAP1B SYT4 SPTAN1

6.62e-05199183058373b4ac3cec2108cb24265628ff0a50646e33
ToppCellCOVID-19-kidney-Fibroblast-1|kidney / Disease (COVID-19 only), tissue and cell type

MAP1B TRPC4 NRP1

6.62e-051991839503646ff1ad248181146ce767e9d12e882ec3bd
ToppCellLPS_IL1RA-Endothelial-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MYO6 SPTAN1 NRP1

6.72e-0520018372ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

MAP1B SYT4 SPTAN1

6.72e-0520018384e4565d28a02700bf7f6730d1b3a58744ca0aea
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal|GW16 / Sample Type, Dataset, Time_group, and Cell type.

MAP1B SYT4 SPTAN1

6.72e-052001831decf1d2cba5ebfd3e5cd4bcd637db8f193033ce
ToppCellcritical-Epithelial-FOXN4+|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CCDC14 PHF10 HELLS

6.72e-05200183f39db4250ce220a3eb58edee3f7fc3671701d46f
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Cortical_neuron|GW16 / Sample Type, Dataset, Time_group, and Cell type.

MAP1B SYT4 SPTAN1

6.72e-0520018319055194a5e0ea122f1b8fc62df44813f6843c95
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal|GW26 / Sample Type, Dataset, Time_group, and Cell type.

MAP1B SYT4 SPTAN1

6.72e-05200183306926cb7a847871641f02e03d52dc56fd55711c
ToppCellLPS_anti-TNF-Endothelial|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

MYO6 SPTAN1 NRP1

6.72e-052001831d105eeda5a2c51f9a4654ffc79b7e2348ad593b
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW09-Neuronal-Neurons|GW09 / Sample Type, Dataset, Time_group, and Cell type.

MYO6 SYT4 SPTAN1

6.72e-05200183ddac952ad1d46021c2d17d816de9bc31730a0941
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal-Cortical_neuron|GW26 / Sample Type, Dataset, Time_group, and Cell type.

MAP1B SYT4 SPTAN1

6.72e-052001835b3df61ff421846ef4cabf1bd5355534c8b95509
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Neuronal|GW10 / Sample Type, Dataset, Time_group, and Cell type.

MAP1B MYO6 SYT4

6.72e-0520018304699d1149a143b96d6f292c0d70c4d3e6dfc611
ToppCellLPS_anti-TNF-Endothelial-Endothelial|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

MYO6 SPTAN1 NRP1

6.72e-0520018360d2cbf41f37f1b11eddb4c9d9246c9c1fc5a5af
ToppCellLPS_only-Endothelial-Endothelial-Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

MYO6 SPTAN1 NRP1

6.72e-05200183432384faeade8e609154fab3d96c955a8ec868dd
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

MAP1B TRPC4 NRP1

6.72e-05200183ad3fb8ef0be45032369d1325024787fbe1dfb8d6
ToppCellLPS_IL1RA-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

MYO6 SPTAN1 NRP1

6.72e-052001835c092b2ecc081b5d04476c56333c338cd89ab984
ToppCellControl_saline-Endothelial|Control_saline / Treatment groups by lineage, cell group, cell type

MYO6 SPTAN1 NRP1

6.72e-052001833372c488a39fe812fa94e4f0564594186fea3db5
ToppCellLPS_only-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

MYO6 SPTAN1 NRP1

6.72e-0520018381e76508c9050d533853d5fd2f3097b27613d836
ToppCellControl_saline-Endothelial-Endothelial-Alv_Gen_Intermediate|Control_saline / Treatment groups by lineage, cell group, cell type

MYO6 SPTAN1 NRP1

6.72e-05200183041a34080120c9f613373c20dcc366292f558040
ToppCellInfluenza-Influenza_Severe-Lymphocyte-T/NK-T/NK_proliferative|Influenza_Severe / Disease, condition lineage and cell class

CBX5 SMC1B HELLS

6.72e-05200183e1c266525ce6b42a4451b6a3b0cabf41ff5e2ee7
ToppCellControl_saline-Endothelial-Endothelial|Control_saline / Treatment groups by lineage, cell group, cell type

MYO6 SPTAN1 NRP1

6.72e-05200183e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-CPNs|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.

MAP1B SYT4 SPTAN1

6.72e-0520018371cbefbef4ae5bbb5f6e419914f4b3b3b5a5f9e3
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Neuronal-Cortical_neuron|3m / Sample Type, Dataset, Time_group, and Cell type.

MAP1B SYT4 SPTAN1

6.72e-05200183c248233b004f8ef0bab3c65ecfe295887966f2ee
ToppCellLPS_only-Endothelial-Endothelial|LPS_only / Treatment groups by lineage, cell group, cell type

MYO6 SPTAN1 NRP1

6.72e-052001834bb609a284d4e6066f17470a1736076aa4a1f84c
Drug$l^{1}-borane

TRPC4 CFDP1 ITPR3

5.38e-0644183CID006397184
DrugPhenformin hydrochloride [834-28-6]; Down 200; 16.6uM; PC3; HT_HG-U133A

MAP1B MYO6 EEA1 NRP1

1.34e-051911844283_DN
DrugCarbenoxolone disodium salt [7421-40-1]; Down 200; 6.6uM; HL60; HT_HG-U133A

SPTAN1 TRPC4 EEA1 ITPR3

1.61e-052001843014_DN
DrugMeglumine [6284-40-8]; Up 200; 20.4uM; HL60; HT_HG-U133A

MAP1B MYO6 SPTAN1 EEA1

1.61e-052001843068_UP
Drugnocodazole

MAP1B MYO6 CBX5 EEA1 ITPR3

2.70e-05477185CID000004122
Diseasediastolic blood pressure, systolic blood pressure

MAP1B SYT4 CCDC62 TRPC4

3.86e-04670164EFO_0006335, EFO_0006336
DiseaseHeadache

GPR149 CFDP1

5.45e-0464162HP_0002315
Diseasemigraine disorder

GPR149 CFDP1 NRP1

8.75e-04357163MONDO_0005277
Diseasemigraine disorder, Headache

GPR149 CFDP1

9.81e-0486162HP_0002315, MONDO_0005277
Diseasevisual epilepsy (biomarker_via_orthology)

MAP1B SYT4

1.07e-0390162DOID:11832 (biomarker_via_orthology)
Diseaseupper face morphology measurement

TRPC4 NRP1

1.25e-0397162EFO_0010949
Diseasecoronary artery disease, factor VII measurement

GPR149 CFDP1

1.63e-03111162EFO_0001645, EFO_0004619
Diseaseresponse to tenofovir, creatinine clearance measurement

SYT4 NRP1

1.65e-03112162EFO_0007934, EFO_0009279
Diseasefactor VIII measurement, coronary artery disease

GPR149 CFDP1

1.68e-03113162EFO_0001645, EFO_0004630
Diseasefactor XI measurement, coronary artery disease

GPR149 CFDP1

1.74e-03115162EFO_0001645, EFO_0004694
Diseasevon Willebrand factor measurement, coronary artery disease

GPR149 CFDP1

1.83e-03118162EFO_0001645, EFO_0004629
Diseaseautism spectrum disorder (implicated_via_orthology)

TRPC4 ITPR3

3.02e-03152162DOID:0060041 (implicated_via_orthology)
Diseasefibrinogen measurement, coronary artery disease

GPR149 CFDP1

3.10e-03154162EFO_0001645, EFO_0004623
Diseaseprostate cancer (is_marker_for)

MYO6 CBX5

3.17e-03156162DOID:10283 (is_marker_for)
Diseasecoronary artery disease

MAP1B GPR149 CFDP1 NRP1

3.29e-031194164EFO_0001645
Diseasecomplement factor H-related protein 3 measurement

CCDC14 SYT4

3.71e-03169162EFO_0600056
DiseaseColorectal Carcinoma

MAP1B CBX5 CCDC62

5.96e-03702163C0009402
Diseaseopioid dependence

MAP1B MYO6

7.16e-03237162EFO_0005611
Diseaseaortic measurement

CFDP1 HELLS

7.99e-03251162EFO_0020865
Diseaseapolipoprotein A 1 measurement

SYT4 GPR149 NRP1

1.00e-02848163EFO_0004614
Diseasemitochondrial DNA measurement

CBX5 ITPR3

1.33e-02328162EFO_0006312

Protein segments in the cluster

PeptideGeneStartEntry
KSNFSNSADDIKSKK

CBX5

91

P45973
EKNQKSLFKDQKFEA

CCDC62

346

Q6P9F0
FNKQDSKADVSQKAD

CCDC74A

191

Q96AQ1
NQKDENKKFSSIFKD

CCDC14

561

Q49A88
DSNLNASRDDKKNKF

ITPR3

816

Q14573
AKKNKKENEDENSSS

HELLS

151

Q9NRZ9
KDKETKNAANASASK

MAP1B

2316

P46821
AKQDSNNKKDAFSDK

GPR149

481

Q86SP6
DDSKRKAKSFEGNNN

NRP1

531

O14786
KKAAKKAAEFNSNLN

PHF10

201

Q8WUB8
NSKSEFEKENQKGKA

EEA1

871

Q15075
SKEAKSFFKQNEKEK

CFDP1

186

Q9UEE9
NLNSKKKFGADDKNE

SYT4

66

Q9H2B2
KNKFNAKQAKQAELD

CFAP210

441

Q0VFZ6
QKAEEDAQFNFNKKK

SMC1B

176

Q8NDV3
KKFDDFQKDLKANES

SPTAN1

1131

Q13813
SDSEGNSKDKKKNFS

TRPC4

781

Q9UBN4
NNNKDTKQKAGKLSF

MYO6

626

Q9UM54