Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF355P SCRT2 ZNF136 ZBTB22 ZBTB41 ZNF225 PRDM5 RFX5 ZNF774 ZBTB24 ZNF419 ZNF250 ZNF547 ZBTB32 ZNF35 ZNF296 ZSCAN22 ZSCAN21 EHMT2 ZNF257 ZNF620 ZNF76 ZNF578 ZNF799 ZNF749 ZNF701 ZNF80 ZNF518B SNAI1 ZNF98 PRDM16 ZNF709 PRDM14	1.65e-10	1459	130	33	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF355P SCRT2 ZNF136 ZBTB22 ZBTB41 ZNF225 PRDM5 RFX5 ZNF774 ZBTB24 ZNF419 ZNF250 ZNF547 ZBTB32 ZNF35 ZSCAN22 ZSCAN21 ZNF257 ZNF620 ZNF76 ZNF578 ZNF799 ZNF749 ZNF701 ZNF80 ZNF518B SNAI1 ZNF98 PRDM16 ZNF709	5.85e-09	1412	130	30	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF355P SCRT2 ZNF136 ZBTB22 ZBTB41 ZNF225 PRDM5 RFX5 ZNF774 ZBTB24 ZNF419 ZNF250 ZNF547 ZBTB32 ZNF296 ZSCAN22 ZSCAN21 ZNF257 ZNF76 ZNF578 ZNF701 SNAI1 ZNF98 PRDM16 ZNF709	3.95e-07	1244	130	25	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF355P SCRT2 ZNF136 ZBTB22 ZBTB41 ZNF225 PRDM5 RFX5 ZNF774 ZBTB24 ZNF419 ZNF250 ZNF547 ZBTB32 ZNF296 ZSCAN22 ZSCAN21 ZNF257 ZNF76 ZNF578 ZNF701 SNAI1 ZNF98 PRDM16 ZNF709	5.88e-07	1271	130	25	GO:0000987
GeneOntologyMolecularFunction	choline-phosphate cytidylyltransferase activity	PCYT1A PCYT1B	4.21e-05	2	130	2	GO:0004105
GeneOntologyMolecularFunction	p53 binding	CHD8 EEF2 EHMT2 PLK3 TP53BP1	1.47e-04	77	130	5	GO:0002039
GeneOntologyMolecularFunction	methyltransferase activity	SETD1B EEF1AKMT3 PRDM5 EHMT2 METTL8 PRDM16 PRDM14	4.97e-04	213	130	7	GO:0008168
GeneOntologyMolecularFunction	transferase activity, transferring one-carbon groups	SETD1B EEF1AKMT3 PRDM5 EHMT2 METTL8 PRDM16 PRDM14	6.69e-04	224	130	7	GO:0016741
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	SETD1B EEF1AKMT3 EHMT2 PRDM16	1.01e-03	68	130	4	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	SETD1B EEF1AKMT3 EHMT2 PRDM16	1.07e-03	69	130	4	GO:0016278
GeneOntologyMolecularFunction	histone H3K9 monomethyltransferase activity	EHMT2 PRDM16	1.15e-03	8	130	2	GO:0140948
GeneOntologyMolecularFunction	histone methyltransferase activity	SETD1B EEF1AKMT3 EHMT2 PRDM16	1.19e-03	71	130	4	GO:0042054
MousePheno	abnormal maxillary-premaxillary suture morphology	FREM1 FGFR1	3.65e-05	2	85	2	MP:0014051
MousePheno	bleb	FRAS1 FREM1 FGFR1	5.94e-05	13	85	3	MP:0008854
MousePheno	increased grooming behavior	ANK2 CHD8 ZNF462 CNTNAP4 TAOK1	8.55e-05	74	85	5	MP:0001441
MousePheno	cryptophthalmos	FRAS1 FREM1	1.09e-04	3	85	2	MP:0005242
MousePheno	decreased social novelty preference	SUPT16H TAOK1	1.09e-04	3	85	2	MP:0014416
Domain	Znf_C2H2/integrase_DNA-bd	SCRT2 ZNF136 ZBTB22 ZNF407 ZBTB41 ZNF225 PRDM5 ZNF774 ZBTB24 ZNF419 ZNF462 ZNF250 ZNF547 ZBTB32 ZNF35 ZNF296 ZSCAN22 ZSCAN21 ZNF257 ZNF620 ZNF76 ZNF578 ZNF799 ZNF749 ZNF701 ZNF80 ZNF518B SNAI1 ZNF98 PRDM16 ZNF709 PRDM14	3.44e-18	694	127	32	IPR013087
Domain	-	SCRT2 ZNF136 ZBTB22 ZNF407 ZBTB41 ZNF225 PRDM5 ZNF774 ZBTB24 ZNF419 ZNF462 ZNF250 ZNF547 ZBTB32 ZNF35 ZNF296 ZSCAN22 ZSCAN21 ZNF257 ZNF620 ZNF76 ZNF578 ZNF799 ZNF749 ZNF701 ZNF80 SNAI1 ZNF98 PRDM16 ZNF709 PRDM14	1.68e-17	679	127	31	3.30.160.60
Domain	zf-C2H2	SCRT2 ZNF136 ZBTB22 ZNF407 ZBTB41 ZNF225 PRDM5 ZNF774 ZBTB24 ZNF419 ZNF462 ZNF250 ZNF547 ZBTB32 ZNF35 ZNF296 ZSCAN22 ZSCAN21 ZNF257 ZNF620 ZNF76 ZNF578 ZNF799 ZNF749 ZNF701 ZNF80 SNAI1 ZNF98 PRDM16 ZNF709 PRDM14	2.98e-17	693	127	31	PF00096
Domain	ZINC_FINGER_C2H2_2	SCRT2 ZNF136 ZBTB22 ZNF407 ZBTB41 ZNF225 PRDM5 ZNF774 ZBTB24 ZNF419 ZNF462 ZNF250 ZNF547 ZBTB32 ZNF35 ZNF296 ZSCAN22 ZSCAN21 ZNF257 ZNF620 ZNF76 ZNF578 ZNF799 ZNF749 ZNF701 ZNF80 ZNF518B SNAI1 ZNF98 PRDM16 ZNF709 PRDM14	8.38e-17	775	127	32	PS50157
Domain	ZINC_FINGER_C2H2_1	SCRT2 ZNF136 ZBTB22 ZNF407 ZBTB41 ZNF225 PRDM5 ZNF774 ZBTB24 ZNF419 ZNF462 ZNF250 ZNF547 ZBTB32 ZNF35 ZNF296 ZSCAN22 ZSCAN21 ZNF257 ZNF620 ZNF76 ZNF578 ZNF799 ZNF749 ZNF701 ZNF80 ZNF518B SNAI1 ZNF98 PRDM16 ZNF709 PRDM14	9.03e-17	777	127	32	PS00028
Domain	Znf_C2H2-like	SCRT2 ZNF136 ZBTB22 ZNF407 ZBTB41 ZNF225 PRDM5 ZNF774 ZBTB24 ZNF419 ZNF462 ZNF250 ZNF547 ZBTB32 ZNF35 ZNF296 ZSCAN22 ZSCAN21 ZNF257 ZNF620 ZNF76 ZNF578 ZNF799 ZNF749 ZNF701 ZNF80 ZNF518B SNAI1 ZNF98 PRDM16 ZNF709 PRDM14	1.80e-16	796	127	32	IPR015880
Domain	Znf_C2H2	SCRT2 ZNF136 ZBTB22 ZNF407 ZBTB41 ZNF225 PRDM5 ZNF774 ZBTB24 ZNF419 ZNF462 ZNF250 ZNF547 ZBTB32 ZNF35 ZNF296 ZSCAN22 ZSCAN21 ZNF257 ZNF620 ZNF76 ZNF578 ZNF799 ZNF749 ZNF701 ZNF80 ZNF518B SNAI1 ZNF98 PRDM16 ZNF709 PRDM14	2.48e-16	805	127	32	IPR007087
Domain	ZnF_C2H2	SCRT2 ZNF136 ZBTB22 ZNF407 ZBTB41 ZNF225 PRDM5 ZNF774 ZBTB24 ZNF419 ZNF462 ZNF250 ZNF547 ZBTB32 ZNF35 ZNF296 ZSCAN22 ZSCAN21 ZNF257 ZNF620 ZNF76 ZNF578 ZNF799 ZNF749 ZNF701 ZNF80 ZNF518B SNAI1 ZNF98 PRDM16 ZNF709 PRDM14	2.76e-16	808	127	32	SM00355
Domain	zf-C2H2_6	SCRT2 ZNF136 ZBTB41 ZNF225 PRDM5 ZBTB24 ZNF419 ZNF250 ZSCAN22 ZNF620 ZNF578 ZNF799 ZNF749 ZNF701 ZNF80 SNAI1 ZNF98 PRDM16 ZNF709	4.08e-13	314	127	19	PF13912
Domain	KRAB	ZNF136 ZNF225 ZNF774 ZNF419 ZNF250 ZNF547 ZNF257 ZNF620 ZNF578 ZNF799 ZNF749 ZNF701 ZNF98 ZNF709	1.54e-07	358	127	14	PS50805
Domain	KRAB	ZNF136 ZNF225 ZNF419 ZNF250 ZNF547 ZNF257 ZNF620 ZNF578 ZNF799 ZNF749 ZNF701 ZNF98 ZNF709	1.01e-06	358	127	13	PF01352
Domain	KRAB	ZNF136 ZNF225 ZNF419 ZNF250 ZNF547 ZNF257 ZNF620 ZNF578 ZNF799 ZNF749 ZNF701 ZNF98 ZNF709	1.41e-06	369	127	13	SM00349
Domain	KRAB	ZNF136 ZNF225 ZNF419 ZNF250 ZNF547 ZNF257 ZNF620 ZNF578 ZNF799 ZNF749 ZNF701 ZNF98 ZNF709	1.46e-06	370	127	13	IPR001909
Domain	SET	SETD1B PRDM5 EHMT2 PRDM16 PRDM14	1.47e-05	46	127	5	SM00317
Domain	SET_dom	SETD1B PRDM5 EHMT2 PRDM16 PRDM14	2.23e-05	50	127	5	IPR001214
Domain	SET	SETD1B PRDM5 EHMT2 PRDM16 PRDM14	2.23e-05	50	127	5	PS50280
Domain	SET	SETD1B PRDM5 EHMT2 PRDM14	1.70e-04	41	127	4	PF00856
Domain	Fumarylacetoacetase_C-rel	FAHD2B FAHD2A	2.73e-04	4	127	2	IPR011234
Domain	FAA_hydrolase	FAHD2B FAHD2A	2.73e-04	4	127	2	PF01557
Domain	-	FAHD2B FAHD2A	2.73e-04	4	127	2	3.90.850.10
Domain	Adcy_conserved_dom	ADCY2 ADCY7	6.76e-04	6	127	2	IPR009398
Domain	DUF1053	ADCY2 ADCY7	6.76e-04	6	127	2	PF06327
Domain	Cyt_trans-like	PCYT1A PCYT1B	9.42e-04	7	127	2	IPR004821
Domain	-	EEF2 SUPT16H	9.42e-04	7	127	2	3.30.70.240
Domain	EFG_V	EEF2 SUPT16H	9.42e-04	7	127	2	IPR000640
Domain	CTP_transf_like	PCYT1A PCYT1B	9.42e-04	7	127	2	PF01467
Domain	AC_N	ADCY2 ADCY7	1.25e-03	8	127	2	IPR032628
Domain	Adcy	ADCY2 ADCY7	1.25e-03	8	127	2	IPR030672
Domain	AC_N	ADCY2 ADCY7	1.25e-03	8	127	2	PF16214
Domain	Calx_beta	FRAS1 FREM1	1.60e-03	9	127	2	IPR003644
Domain	Calx-beta	FRAS1 FREM1	1.60e-03	9	127	2	PF03160
Domain	Kinase-like_dom	BMP2K PDGFRB SCYL2 DST PI4KB ETNK2 TAOK1 FGFR1 PLK3 DYRK2	3.93e-03	542	127	10	IPR011009
Domain	Post-SET_dom	SETD1B EHMT2	5.17e-03	16	127	2	IPR003616
Domain	PostSET	SETD1B EHMT2	5.17e-03	16	127	2	SM00508
Domain	POST_SET	SETD1B EHMT2	5.17e-03	16	127	2	PS50868
Domain	A/G_cyclase_CS	ADCY2 ADCY7	5.84e-03	17	127	2	IPR018297
Domain	Nucleotide_cyclase	ADCY2 ADCY7	6.54e-03	18	127	2	IPR029787
Domain	-	ADCY2 ADCY7	6.54e-03	18	127	2	3.30.70.1230
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF136 PMS2 SETD1B WRN ZNF225 ZNF774 PCF11 ZNF419 ZNF250 AIFM2 ZNF547 EHMT2 ZNF257 SUPT16H ZNF620 SMARCE1 ZNF799 ZNF749 ZNF701 ZNF709 PLK3 DYRK2	7.57e-05	1387	93	22	M734
Pathway	WP_KENNEDY_PATHWAY	PCYT1A ETNK2 PCYT1B	9.60e-05	14	93	3	MM15980
Pathway	WP_KENNEDY_PATHWAY_FROM_SPHINGOLIPIDS	PCYT1A ETNK2 PCYT1B	9.60e-05	14	93	3	M39620
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF136 ZNF419 ZNF250 EHMT2 ZNF257 ZNF620 ZNF799 ZNF749 ZNF701 ZNF98	1.90e-09	181	131	10	37372979
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	PDGFRB CHD8 NUP155 EHMT2 SUPT16H SMARCE1 PCCB	1.98e-07	109	131	7	33554859
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	PCYT1A ZNF136 WRN CHD8 RFX5 ZBTB24 EMSY ZNF462 ZSCAN21 EHMT2 PHF3 SUPT16H SMARCE1	5.54e-07	608	131	13	36089195
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	PCYT1A PMS2 ANK2 ADAMTS1 PDGFRB ITSN1 SEC31A SEC31B RFX5 SCYL2 EEF2 DST EHMT2 ZNF76 SMARCE1 TAOK1 METTL8 PCCB	1.67e-06	1285	131	18	35914814
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZBTB22 ZBTB41 PRDM5 RFX5 ZC3H6 ZBTB24 ZNF419 ZNF462 ZNF296 ZSCAN21 ZNF76 SMARCE1 SNAI1 PRDM16	2.38e-06	808	131	14	20412781
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	HAUS6 PPFIA4 ZNF407 BIRC6 PCF11 ZNF462 DNAH17 CNTNAP4 TAOK1 ZNF518B PRDM16	2.86e-06	493	131	11	15368895
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	CHD8 RFX5 EMSY PCF11 ZSCAN21 EHMT2 PHF3 SMARCE1	8.55e-06	268	131	8	33640491
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	STRBP WRN CHD8 ADAR EMSY PCF11 PHF3 SUPT16H	1.27e-05	283	131	8	30585729
Pubmed	Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant.	PCYT1A PCYT1B	1.41e-05	2	131	2	10480912
Pubmed	Association between KIR gene polymorphisms and type 1 diabetes mellitus (T1DM) susceptibility: A PRISMA-compliant meta-analysis.	KIR2DL1 KIR2DS1	1.41e-05	2	131	2	29384924
Pubmed	Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors.	KIR2DL1 KIR2DS1	1.41e-05	2	131	2	16141329
Pubmed	A distinct neurodevelopmental syndrome with intellectual disability, autism spectrum disorder, characteristic facies, and macrocephaly is caused by defects in CHD8.	CHD8 SUPT16H	1.41e-05	2	131	2	30670789
Pubmed	The Size of Activating and Inhibitory Killer Ig-like Receptor Nanoclusters Is Controlled by the Transmembrane Sequence and Affects Signaling.	KIR2DL1 KIR2DS1	1.41e-05	2	131	2	27210755
Pubmed	KIR2DS1 and KIR2DL1-C245 Dominantly Repress NK Cell Degranulation Triggered by Monoclonal or Bispecific Antibodies, whereas Education by Uptuning Inhibitory Killer Ig-related Receptors Exerts No Advantage in Ab-dependent Cellular Cytotoxicity.	KIR2DL1 KIR2DS1	1.41e-05	2	131	2	38240527
Pubmed	Neurodevelopmental phenotype associated with CHD8-SUPT16H duplication.	CHD8 SUPT16H	1.41e-05	2	131	2	31823155
Pubmed	Differential expression of murine CGI-105 gene in 3T3-L1 cells by adrenocorticotropic hormones.	FAHD2B FAHD2A	1.41e-05	2	131	2	15774318
Pubmed	Overlapping and divergent localization of Frem1 and Fras1 and its functional implications during mouse embryonic development.	FRAS1 FREM1	1.41e-05	2	131	2	17240369
Pubmed	Novel 14q11.2 microduplication including the CHD8 and SUPT16H genes associated with developmental delay.	CHD8 SUPT16H	1.41e-05	2	131	2	26834018
Pubmed	Cdc42 GTPase-activating protein (CdGAP) interacts with the SH3D domain of Intersectin through a novel basic-rich motif.	ITSN1 ARHGAP31	1.41e-05	2	131	2	21349274
Pubmed	DYRK2 controls the epithelial-mesenchymal transition in breast cancer by degrading Snail.	SNAI1 DYRK2	1.41e-05	2	131	2	23791882
Pubmed	Investigation of killer cell immunoglobulin-like receptor gene diversity, KIR2DL1 and KIR2DS1.	KIR2DL1 KIR2DS1	1.41e-05	2	131	2	18643963
Pubmed	Differential dephosphorylation of CTP:phosphocholine cytidylyltransferase upon translocation to nuclear membranes and lipid droplets.	PCYT1A PCYT1B	1.41e-05	2	131	2	32186954
Pubmed	CTP:phosphocholine cytidylyltransferase: Function, regulation, and structure of an amphitropic enzyme required for membrane biogenesis.	PCYT1A PCYT1B	1.41e-05	2	131	2	26165797
Pubmed	Gene structure, expression and identification of a new CTP:phosphocholine cytidylyltransferase beta isoform.	PCYT1A PCYT1B	1.41e-05	2	131	2	12842190
Pubmed	The activity of the GTPase-activating protein CdGAP is regulated by the endocytic protein intersectin.	ITSN1 ARHGAP31	1.41e-05	2	131	2	11744688
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	PCYT1A HAUS6 PMS2 CHD8 ADAR EEF2 EHMT2 PHF3 TAOK1 TP53BP1	2.22e-05	503	131	10	16964243
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	CHD8 BIRC6 ZBTB24 ZNF462 DST PHF3 PRDM16	2.44e-05	225	131	7	12168954
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	HAUS6 BMP2K WRN SEC31A BIRC6 PCF11 EEF2 DST NUP155 EHMT2 PI4KB PCCB	3.99e-05	777	131	12	35844135
Pubmed	Prognostic role of KIR genes and HLA-C after hematopoietic stem cell transplantation in a patient cohort with acute myeloid leukemia from a consanguineous community.	KIR2DL1 KIR2DS1	4.21e-05	3	131	2	29549293
Pubmed	SETD1B Activates iNOS Expression in Myeloid-Derived Suppressor Cells.	SETD1B NOS2	4.21e-05	3	131	2	28381543
Pubmed	Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport.	SEC31A SEC31B	4.21e-05	3	131	2	10788476
Pubmed	Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris.	KIR2DL1 KIR2DS1	4.21e-05	3	131	2	15310528
Pubmed	Methylation of PRDM2, PRDM5 and PRDM16 genes in lung cancer cells.	PRDM5 PRDM16	4.21e-05	3	131	2	24966940
Pubmed	A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle.	FAHD2B FAHD2A	4.21e-05	3	131	2	38287013
Pubmed	Structural and functional integration of the PLCγ interaction domains critical for regulatory mechanisms and signaling deregulation.	PDGFRB FGFR1	4.21e-05	3	131	2	23063561
Pubmed	G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer.	EHMT2 SNAI1	4.21e-05	3	131	2	22406531
Pubmed	FRS2 via fibroblast growth factor receptor 1 is required for platelet-derived growth factor receptor beta-mediated regulation of vascular smooth muscle marker gene expression.	PDGFRB FGFR1	4.21e-05	3	131	2	19339244
Pubmed	Uterine NK cells underexpress KIR2DL1/S1 and LILRB1 in reproductive failure.	KIR2DL1 KIR2DS1	4.21e-05	3	131	2	36713400
Pubmed	Anlotinib inhibits angiogenesis via suppressing the activation of VEGFR2, PDGFRβ and FGFR1.	PDGFRB FGFR1	4.21e-05	3	131	2	29454091
Pubmed	RNF20 Is Critical for Snail-Mediated E-Cadherin Repression in Human Breast Cancer.	EHMT2 SNAI1	4.21e-05	3	131	2	33364200
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZNF407 CNTNAP4 ZNF518B ZC3H12C PRDM16	4.36e-05	102	131	5	11214970
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SETD1B CHD8 ADAR PCF11 NUP155 PHF3 SUPT16H THAP12 TP53BP1	4.64e-05	440	131	9	34244565
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	STRBP CHD8 ADAR RFX5 ZNF774 EMSY PCF11 EEF2 ZSCAN21 PHF3 SUPT16H SMARCE1 TP53BP1	6.77e-05	954	131	13	36373674
Pubmed	Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis.	PRDM5 PRDM16 PRDM14	7.63e-05	22	131	3	19050759
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	PMS2 ITSN1 CHD8 SEC31A ADAR SCYL2 DST PHF3 TP53BP1	7.94e-05	472	131	9	38943005
Pubmed	The role of FREM2 and FRAS1 in the development of congenital diaphragmatic hernia.	FRAS1 FREM1	8.41e-05	4	131	2	29618029
Pubmed	Deficiency of FRAS1-related extracellular matrix 1 (FREM1) causes congenital diaphragmatic hernia in humans and mice.	FRAS1 FREM1	8.41e-05	4	131	2	23221805
Pubmed	A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls.	FRAS1 F5	8.41e-05	4	131	2	23703922
Pubmed	Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis.	FRAS1 FREM1	8.41e-05	4	131	2	36495293
Pubmed	p38 Stabilizes Snail by Suppressing DYRK2-Mediated Phosphorylation That Is Required for GSK3β-βTrCP-Induced Snail Degradation.	SNAI1 DYRK2	8.41e-05	4	131	2	31209060
Pubmed	Peptide-specific engagement of the activating NK cell receptor KIR2DS1.	KIR2DL1 KIR2DS1	8.41e-05	4	131	2	28546555
Pubmed	Differential localization profile of Fras1/Frem proteins in epithelial basement membranes of newborn and adult mice.	FRAS1 FREM1	8.41e-05	4	131	2	18563433
Pubmed	Investigation of activating and inhibitory killer cell immunoglobulin-like receptors and their putative ligands in type 1 diabetes (T1D).	KIR2DL1 KIR2DS1	8.41e-05	4	131	2	26542066
Pubmed	Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome.	ADAMTS1 NOS2	8.41e-05	4	131	2	28067899
Pubmed	Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5.	PRDM5 EHMT2	8.41e-05	4	131	2	17636019
Pubmed	Early embryonic lethality in mice with targeted deletion of the CTP:phosphocholine cytidylyltransferase alpha gene (Pcyt1a).	PCYT1A PCYT1B	8.41e-05	4	131	2	15798219
Pubmed	Molecular genetic characterization of myeloid/lymphoid neoplasms associated with eosinophilia and rearrangement of PDGFRA, PDGFRB, FGFR1 or PCM1-JAK2.	PDGFRB FGFR1	8.41e-05	4	131	2	29567772
Pubmed	ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.	ZBTB22 ZBTB41 ZBTB24 ZBTB32	9.64e-05	63	131	4	34351428
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	EEF2 PHF3 SUPT16H SMARCE1 TAOK1 TP53BP1	1.25e-04	203	131	6	22083510
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	ZBTB22 ZNF407 PRDM5 RFX5 ZBTB24 ZBTB32 ZNF35 ZSCAN21 EHMT2 SMARCE1 SNAI1 PRDM14	1.25e-04	877	131	12	20211142
Pubmed	Increased FGF21 in brown adipose tissue of tyrosine hydroxylase heterozygous mice: implications for cold adaptation.	FGFR1 PRDM16 NOS2	1.27e-04	26	131	3	30352954
Pubmed	Association of killer cell immunoglobulin-like receptor genotypes with vascular arterial events and anticardiolipin antibodies in patients with lupus.	KIR2DL1 KIR2DS1	1.40e-04	5	131	2	18755860
Pubmed	Diversity of the repertoire of p58 killer cell inhibitory receptors in a single individual.	KIR2DL1 KIR2DS1	1.40e-04	5	131	2	10424431
Pubmed	Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function.	KIR2DL1 KIR2DS1	1.40e-04	5	131	2	18624290
Pubmed	Spatiotemporal distribution of Fras1/Frem proteins during mouse embryonic development.	FRAS1 FREM1	1.40e-04	5	131	2	17251066
Pubmed	Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis.	KIR2DL1 KIR2DS1	1.40e-04	5	131	2	16112031
Pubmed	Novel frem1-related mouse phenotypes and evidence of genetic interactions with gata4 and slit3.	FRAS1 FREM1	1.40e-04	5	131	2	23536828
Pubmed	Basement membrane localization of Frem3 is independent of the Fras1/Frem1/Frem2 protein complex within the sublamina densa.	FRAS1 FREM1	1.40e-04	5	131	2	17596926
Pubmed	TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.	SEC31A SCYL2 NUP155	1.60e-04	28	131	3	29653964
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ITSN1 EMSY PCF11 TUBGCP6 EEF2 FBXO4 PHF3 TAOK1 PRPF38A SNAI1 TP53BP1	1.75e-04	774	131	11	15302935
Pubmed	Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.	ZNF462 EEF2 EHMT2 ZNF518B	1.80e-04	74	131	4	29795351
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	HAUS6 CHD8 BIRC6 SFMBT2 ZNF462 DST EHMT2 PCCB	1.95e-04	418	131	8	34709266
Pubmed	Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins.	PDGFRB FGFR1	2.09e-04	6	131	2	7537362
Pubmed	Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract.	FRAS1 FREM1	2.09e-04	6	131	2	24700879
Pubmed	Adams-Oliver Syndrome – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	ARHGAP31 DOCK6	2.09e-04	6	131	2	27077170
Pubmed	Craniofacial consequences of connective tissue disorders in mice.	FRAS1 FREM1	2.09e-04	6	131	2	6391574
Pubmed	Receptor tyrosine kinases fall into distinct classes based on their inferred signaling networks.	PDGFRB FGFR1	2.09e-04	6	131	2	23861540
Pubmed	Tissue factor pathway inhibitor is required for cerebrovascular development in mice.	PDGFRB F5	2.09e-04	6	131	2	32735640
Pubmed	Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue distribution patterns distinct from those of Fras1, Frem2, and QBRICK/Frem1.	FRAS1 FREM1	2.09e-04	6	131	2	17462874
Pubmed	Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.	ZNF462 EHMT2 SMARCE1 PRDM16	2.10e-04	77	131	4	19505873
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	CHD8 EHMT2 SUPT16H SMARCE1 TP53BP1	2.68e-04	150	131	5	28242625
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	ITSN1 ZBTB22 CHD8 ADAR DST SUPT16H ZNF518B	2.75e-04	332	131	7	37433992
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	FRAS1 ITSN1 ADAR FREM1 EFCAB7	2.85e-04	152	131	5	34299191
Pubmed	The yin-yang of PR-domain family genes in tumorigenesis.	PRDM5 PRDM14	2.92e-04	7	131	2	10668202
Pubmed	Coexistence within one cell of microvillous and ciliary phototransductions across M1- through M6-IpRGCs.	ADCY2 ADCY7	2.92e-04	7	131	2	38109525
Pubmed	The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis.	PDGFRB FGFR1	2.92e-04	7	131	2	12783862
Pubmed	Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors.	KIR2DL1 KIR2DS1	2.92e-04	7	131	2	11169255
Pubmed	Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors.	KIR2DL1 KIR2DS1	2.92e-04	7	131	2	9430220
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ANK2 ITSN1 ZBTB22 CHD8 SEC31A EMSY ZNF462 EEF2 DST EHMT2 SUPT16H TP53BP1	2.95e-04	963	131	12	28671696
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	UTP6 STRBP SEC31A ADAR BIRC6 EHMT2 SUPT16H SMARCE1 PRPF38A TP53BP1	3.48e-04	704	131	10	29955894
Pubmed	Interaction network of human early embryonic transcription factors.	CHD8 EMSY ZNF462 EHMT2 DNAAF10 SMARCE1 PRDM16	3.85e-04	351	131	7	38297188
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	PMS2 PDGFRB WRN EMSY EHMT2 NOS2 TP53BP1	3.85e-04	351	131	7	20453000
Pubmed	Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis.	ADAR NOS2	3.88e-04	8	131	2	19667218
Pubmed	FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak.	FGFR1 SNAI1	3.88e-04	8	131	2	11703922
Pubmed	SET domains and histone methylation.	PRDM5 PRDM14	3.88e-04	8	131	2	14675547
Pubmed	Human diversity in killer cell inhibitory receptor genes.	KIR2DL1 KIR2DS1	3.88e-04	8	131	2	9430221
Pubmed	NullHap--a versatile application to estimate haplotype frequencies from unphased genotypes in the presence of null alleles.	KIR2DL1 KIR2DS1	3.88e-04	8	131	2	18681957
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	SETD1B STRBP CHD8 SUPT16H PRPF38A TP53BP1	3.92e-04	251	131	6	31076518
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	SETD1B STRBP CHD8 F5 TUBGCP6 EEF2 NUP155 TP53BP1	4.57e-04	475	131	8	31040226
Pubmed	Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.	HAUS6 ITSN1 SCYL2 NUP155 PRPF38A	4.64e-04	169	131	5	31462741
Cytoband	11q13.5	EMSY THAP12 GVQW3	2.91e-05	21	131	3	11q13.5
Cytoband	19q13.43	ZNF419 ZNF547 ZSCAN22 ZNF749	1.17e-04	87	131	4	19q13.43
Cytoband	Ensembl 112 genes in cytogenetic band chr3q11	OR5K4 OR5K2 OR5K1	5.06e-04	54	131	3	chr3q11
Cytoband	4q21.21	FRAS1 BMP2K	8.28e-04	15	131	2	4q21.21
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	SCRT2 ZNF136 ZBTB22 ZNF407 ZBTB41 ZNF225 PRDM5 ZNF774 ZBTB24 ZNF419 ZNF462 ZNF250 ZNF547 ZBTB32 ZNF35 ZNF296 ZSCAN22 ZSCAN21 ZNF257 ZNF620 ZNF76 ZNF578 ZNF799 ZNF749 ZNF701 ZNF80 ZNF518B SNAI1 ZNF98 PRDM16 ZNF709 PRDM14	6.53e-22	718	93	32	28
GeneFamily	Zinc fingers C2H2-type\|PR/SET domain family	PRDM5 PRDM16 PRDM14	8.50e-05	17	93	3	1197
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETD1B EHMT2 PRDM16	7.02e-04	34	93	3	487
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY2 ADCY7	1.15e-03	10	93	2	53
GeneFamily	Zinc fingers C2H2-type\|SNAG transcriptional repressors	SCRT2 SNAI1	1.15e-03	10	93	2	1259
GeneFamily	Dyneins, axonemal	DNAH3 DNAH17	3.39e-03	17	93	2	536
GeneFamily	CD molecules\|Killer cell immunoglobulin like receptors	KIR2DL1 KIR2DS1	3.80e-03	18	93	2	620
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB22 ZBTB41 ZBTB24 ZBTB32	5.06e-03	134	93	4	861
Coexpression	XIE_TRASTUZUMAB_CARDIOTOXICITY_MMU_MIR_345_5P_GENES	PCYT1A PDGFRB ITSN1 DNAH17 OR5K2 OR5K1	2.57e-06	80	127	6	MM17502
ToppCell	droplet-Kidney-nan-21m-Myeloid-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP2K PPFIA4 VSIR ZNF518B PID1 PCYT1B	1.08e-05	170	130	6	510625bd725d3590cffcd7acd1d42219f6eb1139
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANK2 ADAMTS1 DNAH17 CNTNAP4 FGFR1 PID1	1.36e-05	177	130	6	bd602db857f37869ef76d14c05ef522c509f08ee
ToppCell	MS-Treg-naive_CD4\|MS / Condition, Cell_class and T cell subcluster	WRN F5 ZC3H6 ZNF419 PI4KB ZNF80	1.49e-05	180	130	6	7ca083616926d98420fa11a6e5ebc981623f79ac
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB PPFIA4 PRDM5 F5 SFMBT2 SLC2A12	1.64e-05	183	130	6	3c516fe5083f02bad1f464ed284010b4131a833c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB PPFIA4 PRDM5 F5 SFMBT2 SLC2A12	1.64e-05	183	130	6	9c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB PPFIA4 PRDM5 F5 SFMBT2 SLC2A12	1.69e-05	184	130	6	7294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCell	Multiple_Sclerosis-Lymphocyte-B-B_memory\|Multiple_Sclerosis / Disease, Lineage and Cell Type	STRBP ZBTB32 ZNF296 METTL8 CD180 DOCK6	1.91e-05	188	130	6	8da631b2c75441b7309f03e7d4c14f15f2367be6
ToppCell	BLOOD--(2)_Memory_B_cells\| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	STRBP ZBTB32 ZNF296 METTL8 CD180 DOCK6	2.15e-05	192	130	6	9c3a4699f05f1a757d6e37d9f15675e970584cca
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ANK2 ADAMTS1 PDGFRB FREM1 FGFR1 PID1	2.21e-05	193	130	6	9ab47b360bee1d4f1092c2269e58acebe9584021
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ANK2 ADAMTS1 PDGFRB ITSN1 FREM1 DST	2.63e-05	199	130	6	e1849505b92820a219c5a2c35492bdd55579fb48
ToppCell	MS-Multiple_Sclerosis-Lymphocyte-B-B_memory\|Multiple_Sclerosis / Disease, condition lineage and cell class	STRBP ZBTB32 ZNF296 METTL8 CD180 DOCK6	2.63e-05	199	130	6	ae2979c0d2711580863d3b751f6ff1e3abdfd90e
ToppCell	Macroglial-Astrocytes-SLC14A1---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	BMP2K PDGFRB ITSN1 ADCY2 SFMBT2 PRDM16	2.70e-05	200	130	6	d6fcbf4f4bc1b89a9929d7b114c6b907b6979900
ToppCell	Macroglial-Astrocytes-SLC14A1----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	BMP2K PDGFRB ITSN1 ADCY2 SFMBT2 PRDM16	2.70e-05	200	130	6	f861509b54185d89931db64da1b9d81986cc7938
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ANK2 ADAMTS1 PDGFRB ITSN1 FREM1 DST	2.70e-05	200	130	6	b79628fd1386aa9a3b0e9fa81def0bc100c3c073
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ANK2 ADAMTS1 PDGFRB ITSN1 FREM1 DST	2.70e-05	200	130	6	50ca6550998e461ef26dd670351060bd940765a8
ToppCell	Macroglial-Astrocytes-SLC14A1\|Macroglial / cells hierarchy compared to all cells using T-Statistic	BMP2K PDGFRB ITSN1 ADCY2 SFMBT2 PRDM16	2.70e-05	200	130	6	16f468217427921fa18c6d078ffa990eb019b257
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_only / Treatment groups by lineage, cell group, cell type	ANK2 ADAMTS1 PDGFRB ITSN1 FREM1 DST	2.70e-05	200	130	6	a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCell	Macroglial-Astrocytes-SLC14A1--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	BMP2K PDGFRB ITSN1 ADCY2 SFMBT2 PRDM16	2.70e-05	200	130	6	0442894c39eec69850c090957a5dc7bcecd21e04
ToppCell	Macroglial-Astrocytes-SLC14A1-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	BMP2K PDGFRB ITSN1 ADCY2 SFMBT2 PRDM16	2.70e-05	200	130	6	01819446deeab9054f5cfe889d53bb49d137dbc0
Disease	central nervous system disease (implicated_via_orthology)	SEC31A SEC31B TAOK1	3.90e-05	16	124	3	DOID:331 (implicated_via_orthology)
Disease	Craniosynostosis	FREM1 ZNF462 FGFR1	7.84e-05	20	124	3	C0010278
Disease	Fraser syndrome (implicated_via_orthology)	FRAS1 FREM1	1.05e-04	4	124	2	DOID:0090001 (implicated_via_orthology)
Disease	Adams-Oliver syndrome	ARHGAP31 DOCK6	1.05e-04	4	124	2	cv:C0265268
Disease	hepatitis (biomarker_via_orthology)	F5 NOS2	1.05e-04	4	124	2	DOID:2237 (biomarker_via_orthology)
Disease	atopic asthma	EMSY EHMT2 SMARCE1 FGFR1 THAP12 GVQW3	2.01e-04	199	124	6	EFO_0010638
Disease	Adams Oliver syndrome	ARHGAP31 DOCK6	2.60e-04	6	124	2	C0265268
Disease	Congenital defect of skull and scalp	ARHGAP31 DOCK6	2.60e-04	6	124	2	C2931779
Disease	Adams-Oliver syndrome 1	ARHGAP31 DOCK6	2.60e-04	6	124	2	C4551482
Disease	Adams-Oliver syndrome (is_implicated_in)	ARHGAP31 DOCK6	2.60e-04	6	124	2	DOID:0060227 (is_implicated_in)
Disease	Unilateral agenesis of kidney	FRAS1 FREM1	4.82e-04	8	124	2	C0266294
Disease	interleukin 6 receptor subunit alpha measurement	NUP210L ADAR	1.33e-03	13	124	2	EFO_0008187
Disease	Acute Cerebrovascular Accidents	ANK2 F5 NOS2	1.54e-03	54	124	3	C0751956
Disease	chromosome-type aberration frequency	UTP6 SLC2A12	1.54e-03	14	124	2	EFO_0009861
Disease	obsolete_red blood cell distribution width	SETD1B BMP2K MARCHF8 ITSN1 ZNF407 LMBRD2 BIRC6 ZBTB24 VSIR TAOK1 FGFR1 DOCK6 ZNF709 MPI	1.60e-03	1347	124	14	EFO_0005192
Disease	Mammary Carcinoma, Human	ADAMTS1 ADAR EMSY EEF2 FGFR1 SNAI1 NOS2 TP53BP1	1.73e-03	525	124	8	C4704874
Disease	Mammary Neoplasms, Human	ADAMTS1 ADAR EMSY EEF2 FGFR1 SNAI1 NOS2 TP53BP1	1.73e-03	525	124	8	C1257931
Disease	Mammary Neoplasms	ADAMTS1 ADAR EMSY EEF2 FGFR1 SNAI1 NOS2 TP53BP1	1.77e-03	527	124	8	C1458155
Disease	Breast Carcinoma	ADAMTS1 ADAR EMSY EEF2 FGFR1 SNAI1 NOS2 TP53BP1	2.02e-03	538	124	8	C0678222
Disease	interferon gamma measurement, platelet-derived growth factor BB measurement, interleukin 4 measurement, interleukin 10 measurement, stromal cell-derived factor 1 alpha measurement, interleukin-6 measurement, interleukin 12 measurement, interleukin 17 measurement, vascular endothelial growth factor measurement, fibroblast growth factor basic measurement, granulocyte colony-stimulating factor measurement	PDGFRB F5	2.02e-03	16	124	2	EFO_0004750, EFO_0004753, EFO_0004762, EFO_0004810, EFO_0008130, EFO_0008142, EFO_0008165, EFO_0008174, EFO_0008184, EFO_0008264, EFO_0008293
Disease	Synostotic Posterior Plagiocephaly	FREM1 FGFR1	2.02e-03	16	124	2	C1833340
Disease	Craniosynostosis, Type 1	FREM1 FGFR1	2.02e-03	16	124	2	C4551902
Disease	Acrocephaly	FREM1 FGFR1	2.02e-03	16	124	2	C0030044
Disease	Trigonocephaly	FREM1 FGFR1	2.02e-03	16	124	2	C0265535
Disease	Scaphycephaly	FREM1 FGFR1	2.02e-03	16	124	2	C0265534
Disease	Synostotic Anterior Plagiocephaly	FREM1 FGFR1	2.02e-03	16	124	2	C2931150
Disease	Metopic synostosis	FREM1 FGFR1	2.02e-03	16	124	2	C1860819
Disease	Tinnitus	GATB PAQR5 ITPK1 THAP12	2.24e-03	130	124	4	HP_0000360
Disease	Brachycephaly	FREM1 FGFR1	2.29e-03	17	124	2	C0221356
Disease	Cerebrovascular accident	ANK2 F5 NOS2	2.29e-03	62	124	3	C0038454
Disease	Meningioma	WRN SMARCE1	2.86e-03	19	124	2	C0025286
Disease	triglycerides in very small VLDL measurement	EHMT2 PCCB TP53BP1	2.97e-03	68	124	3	EFO_0022144
Disease	exercise test	WRN ZC3H12C	3.17e-03	20	124	2	EFO_0004328
Disease	allergic disease, age at onset	EMSY SMARCE1 FGFR1	3.36e-03	71	124	3	EFO_0004847, MONDO_0005271
Disease	Antimigraine preparation use measurement	PRDM16 PID1	3.49e-03	21	124	2	EFO_0009939
Disease	Infiltrating duct carcinoma of female breast	PDGFRB FGFR1	3.49e-03	21	124	2	C3165106
Disease	autism spectrum disorder (implicated_via_orthology)	PDGFRB CHD8 CNTNAP4 TAOK1	3.94e-03	152	124	4	DOID:0060041 (implicated_via_orthology)
Disease	cognitive function measurement, self reported educational attainment	WRN GATB BIRC6 CNTNAP4 ZNF799 PCCB	3.96e-03	355	124	6	EFO_0004784, EFO_0008354

Protein segments in the cluster

Peptide	Gene	Start	Entry
GNTHQTHMEESKRFT	nan	456	A8MVM7
HDFHLQAMVRSAGKL	CHD8	1121	Q9HCK8
SSDKRVGRTMSHHAA	BIRC6	4781	Q9NR09
ASQSSGIISMSHHAK	GVQW3	151	Q3ZCU0
HTSAVNKMFSRHNEG	FBXO4	251	Q9UKT5
SHAASFHGDMKLSRE	CNTNAP4	1026	Q9C0A0
ADGEFAVTHMTKAHL	CHRNA2	151	Q15822
VAVAHAGHRRSFSMD	BTBD11	511	A6QL63
NETRSFHHKLGCTMS	GATB	311	O75879
QHFRMSDDVHSLGKV	EHMT2	206	Q96KQ7
KMRKEHGTESFFQHL	EEF1AKMT3	181	Q96AZ1
DRHLSSHFNLRMKGS	CAPN13	481	Q6MZZ7
FHKHQMQDASRDLFT	ADCY7	196	P51828
IDQQAFHSLGKMSHV	CD180	511	Q99467
NSLHGSFHSADVLKM	BMP2K	1106	Q9NSY1
HTMKNEFILTGFTDH	OR5K2	6	Q8NHB8
ISARSAHAHVLKAMG	RFX5	236	P48382
ADQSMAEFHGSGLKH	ADAMTS1	266	Q9UHI8
HCIHFKRDNSSNGRM	GSG1L2	51	A8MUP6
DHFKGISSHSRSSLM	SLC2A12	406	Q8TD20
FSKNDGLKMHIRTHT	PRDM5	526	Q9NQX1
AHTFSSMSKNARHIC	PAQR5	101	Q9NXK6
ANIHMSTKSGLTSLH	ANK2	686	Q01484
GSGMTFQDTLHHKAK	NOS2	91	P35228
GQHFHLTSTFTMKDI	FRAS1	2366	Q86XX4
CKTRVAHGTNSHEMA	ITPK1	156	Q13572
ALLSHDKLMHSQGSF	DST	2226	Q03001
DKLMHSQGSFNDTHT	DST	2231	Q03001
HSRSHMGSAADVRFS	PPFIA4	506	O75335
QDKDGATAMHFAASR	ESPN	236	B1AK53
ATAMHFAASRGHTKV	ESPN	241	B1AK53
SLEGKFHVFDMRTQH	DNAAF10	231	Q96MX6
ALEMAKIHTIHANGS	ETNK2	176	Q9NVF9
KTFHSMKSDGRIHSN	PID1	221	Q7Z2X4
DLFHSGHARALMQAK	PCYT1A	86	P49585
DLFHSGHARALMQAK	PCYT1B	86	Q9Y5K3
SHRHLDAGKLFMVDS	FREM1	691	Q5H8C1
TGNFSTQKVKMHIHS	FOLH1B	26	Q9HBA9
REEQNEKTLGHFMSH	MARCHF8	31	Q5T0T0
EKTLGHFMSHSSNIS	MARCHF8	36	Q5T0T0
FHLKRTALLSHMAGS	TUBGCP6	1646	Q96RT7
KHIKATDAMAHVAGF	FAHD2A	171	Q96GK7
HRMNSAAGHRKALAT	OR2T3	231	Q8NH03
AAGHRKALATCSSHM	OR2T3	236	Q8NH03
IGDEAATHLKQTMSH	MPI	171	P34949
AGHHFEQMLKLSQRS	NUP155	1016	O75694
HTMKNEFILTGFTDH	OR5K1	6	Q8NHB7
VMGQLKFNTSEEHHA	THAP12	611	O43422
SHGKDQSHRKEFLMN	PCF11	306	O94913
GAKTHTTMSGVAHRA	PCCB	246	P05166
HHRDSMTTENGKIST	ADCY2	511	Q08462
NSDSMKGLLRAHGTH	DOCK6	301	Q96HP0
TGSTFHDQIAMLSHR	ADAR	836	P55265
GFMFKRHLSNHVTNS	DNAH17	1081	Q9UFH2
AKSDSIHHMSHSQGQ	DNAH3	41	Q8TD57
SKLMRHQFGNHIEGS	EFCAB7	186	A8K855
KHIKATDAMAHVAGF	FAHD2B	171	Q6P2I3
SGTKKSDFHSQMAVH	FGFR1	401	P11362
RQLFNSHDKTMSGHL	ITSN1	226	Q15811
KMFSEGQLEESHSFH	CCDC73	856	Q6ZRK6
SGQRVFKMTFHHSMT	FBXO24	231	O75426
IVSGTSTRHLHAMAF	MALSU1	126	Q96EH3
VSHTHLGVNMFDKLN	HAUS6	36	Q7Z4H7
MQQALSSHTAFTKHS	EMSY	901	Q7Z589
NMSVIAHVDHGKSTL	EEF2	21	P13639
KTGTITTFEHAHNMR	EEF2	481	P13639
AAAAHTIGGSKHTMN	DYRK2	61	Q92630
HHDGVSKANFSISRM	KIR2DL1	76	P43626
DHVKTSATNRFSRMH	METTL8	131	Q9H825
FHKMLSVSHSQEKEG	CYP8B1	236	Q9UNU6
HNFAMVVHTKAAGRT	NUP210L	1241	Q5VU65
EATAHGLSHSQATMK	PDGFRB	616	P09619
AGAFTIHRHMKIFNS	OR11G2	26	Q8NGC1
HHDGVSKANFSISRM	KIR2DS1	76	Q14954
GAVIHTHSKAAVMAT	APIP	111	Q96GX9
KRHTLHMGSNATGSN	TAS2R39	236	P59534
KRHTLHMGSNATGSR	TAS2R40	221	P59535
SAEAFVAKHAMHQTG	UTP6	581	Q9NYH9
DRSNLRAHMQTHSAF	SCRT2	251	Q9NQ03
SQSSSLNKHMRVHSG	PRDM14	471	Q9GZV8
FSMKHTATARFQRNH	SMARCE1	186	Q969G3
SSEMKKSHEFHAING	F5	1796	P12259
DMKDSFHHNVAALRA	AIFM2	41	Q9BRQ8
NFLGLTHMDSSISHK	LMBRD2	491	Q68DH5
RHQMSHDSGKRFECE	PRDM16	326	Q9HAZ2
SFLHSSVKMVHGNIT	SCYL2	166	Q6P3W7
GDHTVMSNSSVIHLK	TAOK1	386	Q7L7X3
GAKDAVQHLHSTSVM	SETD1B	156	Q9UPS6
SFANDDRHVMVKHST	STRBP	6	Q96SI9
AGMSFSTRKDIHHRF	WRN	796	Q14191
KVSDHSNRMHCSGLA	SEC31B	206	Q9NQW1
SDMHISTQRHSRGTK	PI4KB	221	Q9UBF8
KFSVVSDKNHMHFGA	SUPT16H	256	Q9Y5B9
TGAFKAGNLHSMIHV	OR5K4	146	A6NMS3
HDALFHAKTMGLQTV	PIGA	136	P37287
HAKTMGLQTVFTDHS	PIGA	141	P37287
DGTHMALSANRKTVH	PLK3	491	Q9H4B4
SRMSLLHKHQESGCS	SNAI1	246	O95863
KLLSMHTGHTANIFS	WDTC1	81	Q8N5D0
KCGAAFISNSHLMRH	ZNF35	506	P13682
SHQVVMKDSHASKGA	ZC3H6	981	P61129
GKTFSHRSTLMNHER	ZNF250	401	P15622
MGSTDRHDQRHAGNK	ZNF578	136	Q96N58
ICGKFFSHRSTLNMH	ZNF749	386	O43361
SMGQSSLNRHIKDHS	ZNF136	111	P52737
FGQSSDLLKHQRMHT	ZSCAN21	341	Q9Y5A6
SASDHHGNFSITMRN	VSIR	121	Q9H7M9
KGFRDSSHFVAHMST	ZNF774	326	Q6NX45
IFKGKSSLEMHFRTH	ZBTB41	676	Q5SVQ8
DHADLRSHFFTVGMK	SFMBT2	291	Q5VUG0
SSFTVHQRMHTGEKP	ZNF620	321	Q6ZNG0
GKALSHSSSFRRHMT	ZNF799	371	Q96GE5
MSKDTTSQHRQHLFD	PHF3	1101	Q92576
VHKEMVSLGDSNSHS	TEX13C	406	A0A0J9YWL9
MANRTVKDAHSIHGT	PRPF38A	1	Q8NAV1
RHLAHIASFSSKTNM	ARHGAP31	151	Q2M1Z3
ILMTGGAASVKQHHS	TP53BP1	1891	Q12888
SSSFRMHERTHTGEK	ZNF709	516	Q8N972
HASAKVGTRLMFDHN	PMS2	126	P54278
LEHMSLHSGQKSFTC	ZBTB24	366	O43167
MFQSASALEAHQKTH	ZSCAN22	276	P10073
SKFNLDMHQRVHTGE	ZNF225	551	Q9UK10
RSVFFRHSMTHTAGK	ZNF80	201	P51504
ASSHIFLHGDLRSMK	TRIM51G	296	A0A3B3IT33
NHRVHMAGKTFLCSE	ZNF547	146	Q8IVP9
GKAFNQSSHLTTHKM	ZNF98	496	A6NK75
FKSAFTMHVEAGHSA	ZNF462	2231	Q96JM2
RDFSAMTKHLRTHGA	ZBTB32	411	Q9Y2Y4
QSSKLNEHMRAHTGE	ZNF355P	111	Q9NSJ1
STRNNFMGLKDHLGH	ZC3H12C	26	Q9C0D7
MSSTERHDQRHAGNK	ZNF701	186	Q9NV72
SMAFLAHIRTHTGSK	ZNF407	1551	Q9C0G0
KVSDHSNRMHCSGLA	SEC31A	206	O94979
FNSSLMKHQRIHTGE	ZNF419	326	Q96HQ0
GKAFSHKSMRDRHVN	ZBTB22	491	O15209
QTSTLAMHKRSAHGE	ZNF76	356	P36508
SSFSNLKVHMRSHTG	ZNF296	241	Q8WUU4
SGFSLHANKDKMHNI	ZNF518B	261	Q9C0D4
NQSSALTRHKMTHTG	ZNF257	211	Q9Y2Q1