Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-8 ERVK-24	1.87e-09	37	118	7	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-8 ERVK-24	2.28e-09	38	118	7	GO:0070001
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 POLQ	1.27e-08	14	118	5	GO:0003964
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 POLI POLQ	8.86e-08	38	118	6	GO:0034061
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8	3.70e-07	11	118	4	GO:0004523
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-7 ERVK-10 AGO3 ERVK-8	2.48e-06	37	118	5	GO:0016891
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-7 ERVK-10 ERVK-8	6.42e-06	21	118	4	GO:0035613
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-7 ERVK-10 AGO3 ERVK-8	7.47e-06	46	118	5	GO:0016893
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	ERVK-6 ROR1 LRRK2 CCND1 ERVK-7 ERVK-10 CDK10 CCND3 STK4 JAK3 BRAF ERVK-8 POLI RPS6KA6 MAP3K11 FGR POLQ WNK4	9.77e-06	938	118	18	GO:0016772
GeneOntologyMolecularFunction	acetyl-CoA carboxylase activity	ACACA ACACB	3.46e-05	2	118	2	GO:0003989
GeneOntologyMolecularFunction	kinase binding	PDE8A ACACA APC CCND1 CCND3 PITPNM1 NEDD9 CD2 BRAF AP2A2 PTPRK CD28 LPA MAP3K11 MYOM2 FGR HSP90AA1	5.48e-05	969	118	17	GO:0019900
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-6 ERVK-7 ERVK-10 AGO3 ERVK-8	1.05e-04	79	118	5	GO:0004521
GeneOntologyMolecularFunction	endonuclease activity	ERVK-6 ERVK-7 ERVK-10 AGO3 ERVK-8 POLQ	1.58e-04	136	118	6	GO:0004519
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERVK-6 ERVK-7 MSH4 ERVK-10 LIG3 ERVK-8 POLI POLQ	1.67e-04	262	118	8	GO:0140097
GeneOntologyMolecularFunction	protein kinase activity	ROR1 LRRK2 CCND1 CDK10 CCND3 STK4 JAK3 BRAF RPS6KA6 MAP3K11 FGR WNK4	2.28e-04	600	118	12	GO:0004672
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-8 POLI POLQ	2.88e-04	152	118	6	GO:0016779
GeneOntologyMolecularFunction	histone H3K27me2/H3K27me3 demethylase activity	KDM6A UTY	3.42e-04	5	118	2	GO:0071558
GeneOntologyMolecularFunction	nuclease activity	ERVK-6 ENPP3 ERVK-7 ERVK-10 AGO3 ERVK-8 POLQ	4.50e-04	231	118	7	GO:0004518
GeneOntologyMolecularFunction	CoA carboxylase activity	ACACA ACACB	5.11e-04	6	118	2	GO:0016421
GeneOntologyMolecularFunction	biotin binding	ACACA ACACB	5.11e-04	6	118	2	GO:0009374
GeneOntologyMolecularFunction	MAP kinase kinase kinase activity	LRRK2 BRAF MAP3K11	5.31e-04	27	118	3	GO:0004709
GeneOntologyMolecularFunction	ligase activity, forming carbon-carbon bonds	ACACA ACACB	7.13e-04	7	118	2	GO:0016885
GeneOntologyMolecularFunction	phospholipid transporter activity	ANO9 ATP8A2 ABCA7 PITPNM1	9.69e-04	74	118	4	GO:0005548
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	ROR1 LRRK2 CCND1 CDK10 CCND3 STK4 JAK3 BRAF RPS6KA6 MAP3K11 FGR WNK4	1.00e-03	709	118	12	GO:0016773
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-10 HP LPA ERVK-8 ERVK-24	1.04e-03	430	118	9	GO:0004175
GeneOntologyMolecularFunction	phosphatidylserine floppase activity	ATP8A2 ABCA7	1.21e-03	9	118	2	GO:0090556
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-6 ERVK-7 ERVK-10 AGO3 ERVK-8	1.29e-03	136	118	5	GO:0004540
GeneOntologyMolecularFunction	hemoglobin binding	CUBN HP	1.84e-03	11	118	2	GO:0030492
GeneOntologyMolecularFunction	kinase activity	ROR1 LRRK2 CCND1 CDK10 CCND3 STK4 JAK3 BRAF RPS6KA6 MAP3K11 FGR WNK4	1.89e-03	764	118	12	GO:0016301
GeneOntologyMolecularFunction	protein kinase binding	APC CCND1 CCND3 PITPNM1 NEDD9 CD2 BRAF AP2A2 PTPRK CD28 MAP3K11 FGR HSP90AA1	1.96e-03	873	118	13	GO:0019901
GeneOntologyMolecularFunction	gamma-catenin binding	APC PTPRK	2.20e-03	12	118	2	GO:0045295
GeneOntologyMolecularFunction	JUN kinase kinase kinase activity	LRRK2 MAP3K11	2.20e-03	12	118	2	GO:0004706
GeneOntologyBiologicalProcess	DNA synthesis involved in DNA repair	ERVK-6 ERVK-7 ERVK-10 ZBTB1 ERVK-8 POLI POLQ	1.08e-08	48	119	7	GO:0000731
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-7 ERVK-10 ERVK-8	7.23e-07	13	119	4	GO:0015074
GeneOntologyBiologicalProcess	DNA biosynthetic process	ERVK-6 ERVK-7 ERVK-10 ZBTB1 LIG3 ERVK-8 POLI POLQ HSP90AA1	4.94e-06	218	119	9	GO:0071897
GeneOntologyBiologicalProcess	RNA-templated DNA biosynthetic process	ERVK-6 ERVK-7 ERVK-10 ERVK-8 POLQ HSP90AA1	8.54e-06	83	119	6	GO:0006278
GeneOntologyBiologicalProcess	DNA recombination	ERVK-6 MCMDC2 ERVK-7 MSH4 ERVK-10 LIG3 CD28 PAXIP1 ERVK-8 POLQ PARPBP	9.48e-06	368	119	11	GO:0006310
GeneOntologyBiologicalProcess	trehalose metabolic process	BRAF TREH	3.30e-05	2	119	2	GO:0005991
GeneOntologyBiologicalProcess	malonyl-CoA biosynthetic process	ACACA ACACB	3.30e-05	2	119	2	GO:2001295
GeneOntologyBiologicalProcess	DNA damage response	ERVK-6 APC CBX3 CCND1 MCMDC2 ERVK-7 MSH4 ERVK-10 ZBTB1 LIG3 TEX264 PAXIP1 ERVK-8 POLI RPS6KA6 POLQ PARPBP	3.60e-05	959	119	17	GO:0006974
GeneOntologyBiologicalProcess	viral process	ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-10 PAIP1 CD28 ERVK-8 ERVK-5 ST6GALNAC4 ERVK-24	7.89e-05	464	119	11	GO:0016032
GeneOntologyBiologicalProcess	protein insertion into mitochondrial outer membrane	SAMM50 MTCH1 HSP90AA1	8.10e-05	15	119	3	GO:0045040
GeneOntologyBiologicalProcess	positive regulation of protein metabolic process	NELFA LRRK2 APC CCND1 PLXNB2 PAIP1 CCND3 NEDD9 STK4 OSM BRAF CD28 PAXIP1 PPP1R16B MAP3K11 UBR3 MTCH1 WNK4 SMYD3 HSP90AA1 HDAC2	8.50e-05	1458	119	21	GO:0051247
GeneOntologyBiologicalProcess	DNA repair	ERVK-6 MCMDC2 ERVK-7 MSH4 ERVK-10 ZBTB1 LIG3 TEX264 PAXIP1 ERVK-8 POLI POLQ PARPBP	9.50e-05	648	119	13	GO:0006281
GeneOntologyBiologicalProcess	immune system development	APC ZBTB1 JAK3 LIG3 BRAF CD28 PAXIP1 POLQ	9.71e-05	248	119	8	GO:0002520
GeneOntologyBiologicalProcess	outer mitochondrial membrane organization	SAMM50 MTCH1 HSP90AA1	9.93e-05	16	119	3	GO:0007008
GeneOntologyBiologicalProcess	nitrate metabolic process	POR MTARC2	1.97e-04	4	119	2	GO:0042126
GeneOntologyBiologicalProcess	regulation of phosphorylation	ROR1 LRRK2 APC CCND1 PLXNB2 CCND3 NEDD9 STK4 OSM BRAF PTPRQ FSHR MAP3K11 FGR WNK4 SMYD3 HSP90AA1 HDAC2	2.30e-04	1226	119	18	GO:0042325
GeneOntologyBiologicalProcess	regulation of protein phosphorylation	LRRK2 APC CCND1 PLXNB2 CCND3 NEDD9 STK4 OSM BRAF PTPRQ FSHR MAP3K11 FGR WNK4 SMYD3 HSP90AA1 HDAC2	2.71e-04	1133	119	17	GO:0001932
GeneOntologyCellularComponent	MLL3/4 complex	PAXIP1 KDM6A UTY	3.62e-05	12	117	3	GO:0044666
Domain	ACC_central	ACACA ACACB	3.37e-05	2	109	2	PF08326
Domain	AcCoA_COase_cen	ACACA ACACB	3.37e-05	2	109	2	IPR013537
Domain	Cyclin_D	CCND1 CCND3	1.01e-04	3	109	2	IPR015451
Domain	PPR	DENND4A DENND4C	2.01e-04	4	109	2	PF01535
Domain	Carboxyl_trans	ACACA ACACB	2.01e-04	4	109	2	PF01039
Domain	COA_CT_CTER	ACACA ACACB	2.01e-04	4	109	2	PS50989
Domain	COA_CT_NTER	ACACA ACACB	2.01e-04	4	109	2	PS50980
Domain	COA_CT_N	ACACA ACACB	2.01e-04	4	109	2	IPR011762
Domain	COA_CT_C	ACACA ACACB	2.01e-04	4	109	2	IPR011763
Domain	Carboxyl_trans	ACACA ACACB	2.01e-04	4	109	2	IPR000022
Domain	Biotin_BS	ACACA ACACB	3.34e-04	5	109	2	IPR001882
Domain	Biotin_COase_C	ACACA ACACB	3.34e-04	5	109	2	IPR005482
Domain	BC	ACACA ACACB	3.34e-04	5	109	2	PS50979
Domain	Biotin_carb_C	ACACA ACACB	3.34e-04	5	109	2	SM00878
Domain	Biotin_carb_C	ACACA ACACB	3.34e-04	5	109	2	PF02785
Domain	Biotin_carboxylation_dom	ACACA ACACB	3.34e-04	5	109	2	IPR011764
Domain	CPSASE_1	ACACA ACACB	3.34e-04	5	109	2	PS00866
Domain	BIOTIN	ACACA ACACB	3.34e-04	5	109	2	PS00188
Domain	PROTEIN_KINASE_ATP	ROR1 LRRK2 CDK10 STK4 JAK3 BRAF RPS6KA6 MAP3K11 FGR WNK4	3.55e-04	459	109	10	PS00107
Domain	Rudment_hybrid_motif	ACACA ACACB	4.99e-04	6	109	2	IPR011054
Domain	CPSASE_2	ACACA ACACB	4.99e-04	6	109	2	PS00867
Domain	Prot_kinase_dom	ROR1 LRRK2 CDK10 STK4 JAK3 BRAF RPS6KA6 MAP3K11 FGR WNK4	5.82e-04	489	109	10	IPR000719
Domain	PROTEIN_KINASE_DOM	ROR1 LRRK2 CDK10 STK4 JAK3 BRAF RPS6KA6 MAP3K11 FGR WNK4	6.19e-04	493	109	10	PS50011
Domain	CbamoylP_synth_lsu-like_ATP-bd	ACACA ACACB	6.95e-04	7	109	2	IPR005479
Domain	BC-like_N	ACACA ACACB	6.95e-04	7	109	2	IPR005481
Domain	Yip1	YIPF7 YIPF5	6.95e-04	7	109	2	IPR006977
Domain	CPSase_L_D2	ACACA ACACB	6.95e-04	7	109	2	PF02786
Domain	Yip1	YIPF7 YIPF5	6.95e-04	7	109	2	PF04893
Domain	Biotin_carb_N	ACACA ACACB	6.95e-04	7	109	2	PF00289
Domain	PPR	DENND4A DENND4C	9.24e-04	8	109	2	PS51375
Domain	Pkinase_Tyr	ROR1 JAK3 BRAF MAP3K11 FGR	9.57e-04	129	109	5	PF07714
Domain	Biotin_lipoyl	ACACA ACACB	1.18e-03	9	109	2	PF00364
Domain	Kinase-like_dom	ROR1 LRRK2 CDK10 STK4 JAK3 BRAF RPS6KA6 MAP3K11 FGR WNK4	1.27e-03	542	109	10	IPR011009
Domain	Ser-Thr/Tyr_kinase_cat_dom	ROR1 JAK3 BRAF MAP3K11 FGR	1.29e-03	138	109	5	IPR001245
Domain	BIOTINYL_LIPOYL	ACACA ACACB	1.47e-03	10	109	2	PS50968
Domain	Biotin_lipoyl	ACACA ACACB	1.47e-03	10	109	2	IPR000089
Domain	Protein_kinase_ATP_BS	LRRK2 CDK10 STK4 JAK3 BRAF RPS6KA6 MAP3K11 FGR	1.71e-03	379	109	8	IPR017441
Domain	Tyr_kinase_cat_dom	ROR1 JAK3 MAP3K11 FGR	1.76e-03	88	109	4	IPR020635
Domain	TyrKc	ROR1 JAK3 MAP3K11 FGR	1.76e-03	88	109	4	SM00219
Domain	Single_hybrid_motif	ACACA ACACB	2.14e-03	12	109	2	IPR011053
Domain	-	ACACA ACACB	2.52e-03	13	109	2	3.40.50.20
Domain	ATP_GRASP	ACACA ACACB	2.93e-03	14	109	2	PS50975
Domain	ATP-grasp	ACACA ACACB	2.93e-03	14	109	2	IPR011761
Domain	PreATP-grasp_dom	ACACA ACACB	2.93e-03	14	109	2	IPR016185
Domain	-	ARID4B ARID5B	3.37e-03	15	109	2	1.10.150.60
Domain	BRIGHT	ARID4B ARID5B	3.37e-03	15	109	2	SM00501
Domain	ARID_dom	ARID4B ARID5B	3.37e-03	15	109	2	IPR001606
Domain	ARID	ARID4B ARID5B	3.37e-03	15	109	2	PS51011
Domain	ARID	ARID4B ARID5B	3.37e-03	15	109	2	PF01388
Domain	-	ACACA ACACB	3.37e-03	15	109	2	3.30.1490.20
Domain	TPR_8	TTC21B KDM6A UTY	3.66e-03	53	109	3	PF13181
Domain	ARM-type_fold	MON2 LRRK2 USP24 APC PAIP1 AP2A2 CFAP69	3.74e-03	339	109	7	IPR016024
Domain	DENN	DENND4A DENND4C	3.84e-03	16	109	2	SM00799
Domain	DENN	DENND4A DENND4C	3.84e-03	16	109	2	PF02141
Domain	dDENN	DENND4A DENND4C	3.84e-03	16	109	2	PF03455
Domain	UDENN	DENND4A DENND4C	3.84e-03	16	109	2	PS50946
Domain	DDENN	DENND4A DENND4C	3.84e-03	16	109	2	PS50947
Domain	dDENN	DENND4A DENND4C	3.84e-03	16	109	2	SM00801
Domain	dDENN_dom	DENND4A DENND4C	3.84e-03	16	109	2	IPR005112
Domain	uDENN_dom	DENND4A DENND4C	3.84e-03	16	109	2	IPR005113
Domain	DENN	DENND4A DENND4C	3.84e-03	16	109	2	PS50211
Domain	DENN_dom	DENND4A DENND4C	3.84e-03	16	109	2	IPR001194
Domain	Kringle_CS	ROR1 LPA	4.33e-03	17	109	2	IPR018056
Domain	Cyclin_C-dom	CCND1 CCND3	4.33e-03	17	109	2	IPR004367
Domain	KRINGLE_1	ROR1 LPA	4.33e-03	17	109	2	PS00021
Domain	KR	ROR1 LPA	4.33e-03	17	109	2	SM00130
Domain	Kringle	ROR1 LPA	4.33e-03	17	109	2	IPR000001
Domain	Cyclin_C	CCND1 CCND3	4.33e-03	17	109	2	PF02984
Domain	KRINGLE_2	ROR1 LPA	4.33e-03	17	109	2	PS50070
Domain	Kringle	ROR1 LPA	4.33e-03	17	109	2	PF00051
Domain	Cyclin_C	CCND1 CCND3	4.33e-03	17	109	2	SM01332
Domain	ATP_grasp_subdomain_1	ACACA ACACB	4.86e-03	18	109	2	IPR013815
Domain	-	ACACA ACACB	4.86e-03	18	109	2	3.30.470.20
Domain	Ser/Thr_kinase_AS	LRRK2 CDK10 STK4 BRAF RPS6KA6 MAP3K11 WNK4	4.95e-03	357	109	7	IPR008271
Domain	S_TKc	LRRK2 CDK10 STK4 BRAF RPS6KA6 MAP3K11 WNK4	5.11e-03	359	109	7	SM00220
Domain	PROTEIN_KINASE_ST	LRRK2 CDK10 STK4 BRAF RPS6KA6 MAP3K11 WNK4	5.34e-03	362	109	7	PS00108
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-10 ERVK-24	1.30e-10	4	119	4	10469592
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-8 ERVK-5 ERVK-24	1.29e-09	94	119	8	21542922
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-21 ERVK-9 ERVK-8	6.31e-08	12	119	4	14557543
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-10 ERVK-5	1.56e-07	4	119	3	7983737
Pubmed	Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.	ROR1 APC BRAF KDM6A HSP90AA1 HDAC2	1.69e-07	71	119	6	28319113
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	ATP8A2 USP24 APC CCND1 PLXNB2 CDK10 CCND3 STK4 BRAF AP2A2 RPS6KA6 FGR WNK4 HDAC2	2.21e-07	730	119	14	34857952
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-21 ERVK-9 ERVK-10 ERVK-24	3.84e-07	18	119	4	18664271
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-7 ERVK-21	3.89e-07	5	119	3	12629516
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-7 ERVK-5	3.89e-07	5	119	3	11401426
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	MON2 DENND4A PDE8A POR DENND4C SH3BP4 NBAS TEX264 PLEKHM3 SAMM50	9.71e-06	504	119	10	34432599
Pubmed	Deregulation of D-type cyclins in uterine cancers. Cyclin D1/D3 is differentially expressed in cervical cancer.	CCND1 CCND3	1.16e-05	2	119	2	14666699
Pubmed	An H-YDb epitope is encoded by a novel mouse Y chromosome gene.	KDM6A UTY	1.16e-05	2	119	2	8944031
Pubmed	Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.	ACACA ACACB	1.16e-05	2	119	2	24944901
Pubmed	Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice.	APC HDAC2	1.16e-05	2	119	2	17909008
Pubmed	Anaphylactic transfusion reaction in homozygous haptoglobin deficiency detected by CD203c expression on basophils.	ENPP3 HP	1.16e-05	2	119	2	24497482
Pubmed	Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf.	APC BRAF	1.16e-05	2	119	2	19378335
Pubmed	Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription.	ACACA ACACB	1.16e-05	2	119	2	20139635
Pubmed	Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice.	APC CCND1	1.16e-05	2	119	2	18716166
Pubmed	Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.	ACACA ACACB	1.16e-05	2	119	2	28081256
Pubmed	Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.	ACACA ACACB	1.16e-05	2	119	2	26976583
Pubmed	Overcoming acquired BRAF inhibitor resistance in melanoma via targeted inhibition of Hsp90 with ganetespib.	BRAF HSP90AA1	1.16e-05	2	119	2	24398428
Pubmed	A membrane protein enriched in endoplasmic reticulum exit sites interacts with COPII.	YIPF7 YIPF5	1.16e-05	2	119	2	11489904
Pubmed	Cyclin D1 inactivation extends proliferation and alters histogenesis in the postnatal mouse retina.	CCND1 CCND3	1.16e-05	2	119	2	22434780
Pubmed	Hypermethylation of the RSK4 promoter associated with BRAF V600E promotes papillary thyroid carcinoma.	BRAF RPS6KA6	1.16e-05	2	119	2	32319586
Pubmed	AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation.	ACACA ACACB	1.16e-05	2	119	2	25001074
Pubmed	Cyclin D1 and cyclin D3 show divergent responses to distinct mitogenic stimulation.	CCND1 CCND3	1.16e-05	2	119	2	20458731
Pubmed	The subcellular localization of acetyl-CoA carboxylase 2.	ACACA ACACB	1.16e-05	2	119	2	10677481
Pubmed	Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA carboxylases 1 and 2.	ACACA ACACB	1.16e-05	2	119	2	24338821
Pubmed	T cell-signaling network analysis reveals distinct differences between CD28 and CD2 costimulation responses in various subsets and in the MAPK pathway between resting and activated regulatory T cells.	CD2 CD28	1.16e-05	2	119	2	22013130
Pubmed	De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.	ACACA ACACB	1.16e-05	2	119	2	25282359
Pubmed	Coordinate regulation of T cell activation by CD2 and CD28.	CD2 CD28	1.16e-05	2	119	2	10725714
Pubmed	Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab.	ACACA ACACB	1.16e-05	2	119	2	27693630
Pubmed	Combined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor development.	CCND1 CCND3	1.16e-05	2	119	2	22214766
Pubmed	Correlation of cyclin D1 and cyclin D3 overexpression with the loss of PTEN expression in endometrial carcinoma.	CCND1 CCND3	1.16e-05	2	119	2	16884382
Pubmed	Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue.	ACACA ACACB	1.16e-05	2	119	2	32215608
Pubmed	C-terminal domain of SMYD3 serves as a unique HSP90-regulated motif in oncogenesis.	SMYD3 HSP90AA1	1.16e-05	2	119	2	25738358
Pubmed	Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor.	ACACA ACACB	1.16e-05	2	119	2	29772612
Pubmed	Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin.	ACACA ACACB	1.16e-05	2	119	2	29976587
Pubmed	Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons.	KDM6A UTY	1.16e-05	2	119	2	18434530
Pubmed	Structure and regulation of acetyl-CoA carboxylase genes of metazoa.	ACACA ACACB	1.16e-05	2	119	2	15749055
Pubmed	Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer.	KDM6A UTY	1.16e-05	2	119	2	27533081
Pubmed	Estrogen-induced cyclin D1 and D3 gene expressions during mouse uterine cell proliferation in vivo: differential induction mechanism of cyclin D1 and D3.	CCND1 CCND3	1.16e-05	2	119	2	9094091
Pubmed	BRAF mutations, microsatellite instability status and cyclin D1 expression predict metastatic colorectal patients' outcome.	CCND1 BRAF	1.16e-05	2	119	2	20485284
Pubmed	T cell costimulatory molecule function determines susceptibility to infection with Pneumocystis carinii in mice.	CD2 CD28	1.16e-05	2	119	2	12902500
Pubmed	Positive and negative selection on mammalian Y chromosomes.	KDM6A UTY	1.16e-05	2	119	2	15758204
Pubmed	Lysine demethylases KDM6A and UTY: The X and Y of histone demethylation.	KDM6A UTY	1.16e-05	2	119	2	31097364
Pubmed	AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis.	ACACA ACACB	1.16e-05	2	119	2	29433631
Pubmed	Differential regulation of cyclins D1 and D3 in hepatocyte proliferation.	CCND1 CCND3	1.16e-05	2	119	2	12085346
Pubmed	The requirement for cyclin D function in tumor maintenance.	CCND1 CCND3	1.16e-05	2	119	2	23079655
Pubmed	HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression.	APC NEDD9	1.16e-05	2	119	2	21317929
Pubmed	Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin.	ACACA ACACB	1.16e-05	2	119	2	36076520
Pubmed	Differential roles of cyclin D1 and D3 in pancreatic ductal adenocarcinoma.	CCND1 CCND3	1.16e-05	2	119	2	20113529
Pubmed	The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor.	CCND1 CCND3	1.16e-05	2	119	2	26055066
Pubmed	Differential utilization of cyclin D1 and cyclin D3 in the distinct mitogenic stimulations by growth factors and TSH of human thyrocytes in primary culture.	CCND1 CCND3	1.16e-05	2	119	2	16916940
Pubmed	Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.	ACACA ACACB	1.16e-05	2	119	2	28290443
Pubmed	Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.	ACACA ACACB	1.16e-05	2	119	2	30244972
Pubmed	BRAF inhibitor therapy-associated melanocytic lesions lack the BRAF V600E mutation and show increased levels of cyclin D1 expression.	CCND1 BRAF	1.16e-05	2	119	2	26997441
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ACACA ACACB USP24 APC CBX3 ZBTB1 DENND4C ARID5B HDAC2	1.45e-05	418	119	9	34709266
Pubmed	Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.	APC CCND1 MSH4 LIG3 BRAF HDAC2	2.74e-05	170	119	6	19064572
Pubmed	AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue.	ACACA ACACB	3.47e-05	3	119	2	34668531
Pubmed	Targeted expression of cyclin D2 results in cardiomyocyte DNA synthesis and infarct regression in transgenic mice.	CCND1 CCND3	3.47e-05	3	119	2	15576649
Pubmed	Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges.	DENND4A DENND4C	3.47e-05	3	119	2	12906859
Pubmed	AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation.	ACACA ACACB	3.47e-05	3	119	2	30018077
Pubmed	PIK3CA mutation is a favorable prognostic factor in esophageal cancer: molecular profile by next-generation sequencing using surgically resected formalin-fixed, paraffin-embedded tissue.	APC BRAF	3.47e-05	3	119	2	30115035
Pubmed	Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP.	LRRK2 HSP90AA1	3.47e-05	3	119	2	19536328
Pubmed	Role of LXCXE motif-dependent interactions in the activity of the retinoblastoma protein.	CCND1 HDAC2	3.47e-05	3	119	2	11593423
Pubmed	Translesion synthesis DNA polymerases promote error-free replication through the minor-groove DNA adduct 3-deaza-3-methyladenine.	POLI POLQ	3.47e-05	3	119	2	28939775
Pubmed	Oncostatin M induces growth arrest of skeletal muscle cells in G1 phase by regulating cyclin D1 protein level.	CCND1 OSM	3.47e-05	3	119	2	17976956
Pubmed	Oncostatin M decreases adiponectin expression and induces dedifferentiation of adipocytes by JAK3- and MEK-dependent pathways.	JAK3 OSM	3.47e-05	3	119	2	17081797
Pubmed	KIF17 stabilizes microtubules and contributes to epithelial morphogenesis by acting at MT plus ends with EB1 and APC.	APC KIF17	3.47e-05	3	119	2	20696710
Pubmed	Promoter hypermethylation as an independent prognostic factor for relapse in patients with prostate cancer following radical prostatectomy.	APC CCND1	3.47e-05	3	119	2	16322291
Pubmed	p53, Cyclin-D1, β-catenin, APC and c-myc in Tumor Tissue from Colorectal and Gastric Cancer Patients with Suspected Lynch Syndrome by the Bethesda Criteria.	APC CCND1	3.47e-05	3	119	2	32102509
Pubmed	Involvement of the D-type cyclins in germ cell proliferation and differentiation in the mouse.	CCND1 CCND3	3.47e-05	3	119	2	11090462
Pubmed	Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels.	ACACA ACACB	3.47e-05	3	119	2	19846279
Pubmed	Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels.	ACACA ACACB	3.47e-05	3	119	2	18031993
Pubmed	BRAFV600E drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation.	APC BRAF	3.47e-05	3	119	2	32792685
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-9	3.47e-05	3	119	2	9971820
Pubmed	Malignant struma ovarii: next-generation sequencing of six cases revealed Nras, Braf, and Jak3 mutations.	JAK3 BRAF	3.47e-05	3	119	2	32743766
Pubmed	Cyclin D1 is not an essential target of beta-catenin signaling during intestinal tumorigenesis, but it may act as a modifier of disease severity in multiple intestinal neoplasia (Min) mice.	APC CCND1	3.47e-05	3	119	2	12183406
Pubmed	Physical interaction of the retinoblastoma protein with human D cyclins.	CCND1 CCND3	3.47e-05	3	119	2	8490963
Pubmed	Cyclin D3 compensates for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression.	CCND1 CCND3	3.47e-05	3	119	2	22037875
Pubmed	Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis.	ACACA ACACB	3.47e-05	3	119	2	20457939
Pubmed	Segment- and cell-specific expression of D-type cyclins in the postnatal mouse epididymis.	CCND1 CCND3	3.47e-05	3	119	2	22289519
Pubmed	Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism.	ACACA ACACB	3.47e-05	3	119	2	36417534
Pubmed	Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct.	POLI POLQ	3.47e-05	3	119	2	29330301
Pubmed	The phosphatidylinositol phosphatase PTEN is under control of costimulation and regulates proliferation in human T cells.	CD2 CD28	3.47e-05	3	119	2	11932928
Pubmed	Herpes simplex virus 1 mutant in which the ICP0 HUL-1 E3 ubiquitin ligase site is disrupted stabilizes cdc34 but degrades D-type cyclins and exhibits diminished neurotoxicity.	CCND1 CCND3	3.47e-05	3	119	2	14645576
Pubmed	Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma.	CCND1 CCND3	3.47e-05	3	119	2	15755896
Pubmed	The UTX gene escapes X inactivation in mice and humans.	KDM6A UTY	3.47e-05	3	119	2	9499428
Pubmed	[Characterization of genetic alterations in primary human melanomas carrying BRAF or NRAS mutation].	CCND1 BRAF	3.47e-05	3	119	2	23795354
Pubmed	The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity.	LRRK2 HSP90AA1	3.47e-05	3	119	2	16321986
Pubmed	Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate.	ACACA ACACB	3.47e-05	3	119	2	18455495
Pubmed	Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma.	ROR1 HSP90AA1	3.47e-05	3	119	2	33370472
Pubmed	Altered expression of cell cycle regulatory proteins in benign and malignant bone and soft tissue neoplasms.	CCND1 CCND3	3.47e-05	3	119	2	18019405
Pubmed	D-type cyclin-binding regions of proliferating cell nuclear antigen.	CCND1 CCND3	3.47e-05	3	119	2	7908906
Pubmed	SH3BP4 Regulates Intestinal Stem Cells and Tumorigenesis by Modulating β-Catenin Nuclear Localization.	APC SH3BP4	3.47e-05	3	119	2	30811977
Pubmed	Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen.	CCND1 CCND3	3.47e-05	3	119	2	20090754
Pubmed	CircPLXNB2 regulates acute myeloid leukemia progression through miR-654-3p/CCND1 axis.	CCND1 PLXNB2	3.47e-05	3	119	2	37272581
Pubmed	Polymorphic loci of E2F2, CCND1 and CCND3 are associated with HER2 status of breast tumors.	CCND1 CCND3	3.47e-05	3	119	2	19142864
Pubmed	Increased cancer predisposition in family members of colorectal cancer patients harboring the p.V600E BRAF mutation: a population-based study.	APC BRAF	3.47e-05	3	119	2	20570909
Interaction	H2AZ1 interactions	ARID4B ACACA NELFA CBX3 ZBTB1 CDK10 LIG3 BRAF ARID5B RPS6KA6 FGR HDAC2	1.07e-06	371	112	12	int:H2AZ1
GeneFamily	Yip1 domain containing	YIPF7 YIPF5	3.61e-04	7	76	2	105
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	TTC9C TTC21B KDM6A UTY	1.40e-03	115	76	4	769
GeneFamily	AT-rich interaction domain containing	ARID4B ARID5B	1.77e-03	15	76	2	418
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRK PTPRQ	3.48e-03	21	76	2	813
GeneFamily	DNA polymerases	POLI POLQ	4.17e-03	23	76	2	535
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	BRAF MAP3K11	4.53e-03	24	76	2	654
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM6A UTY	4.53e-03	24	76	2	485
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND4A DENND4C	4.91e-03	25	76	2	504
ToppCell	renal_cortex_nuclei-Adult_normal_reference\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	MON2 PDE8A ACACB ENPP3 CCND3 NEDD9 PPP1R16B MCF2L UTY	1.08e-09	189	110	9	a48df46274d51e84ffb40264646de7346104efb9
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MCMDC2 RCAN3 CCND3 STK4 JAK3 CD2 POLR3E CD28 ARID5B	1.63e-09	198	110	9	8a7897d98f5296745d9005a7cd777f0a2f78000d
ToppCell	normal-na-Lymphocytic_T-T4_em-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	CFH ARID4B NLGN4Y RCAN3 STK4 CD2 ARID5B UTY	1.09e-08	171	110	8	61318a7aaf3bd8bdd28f8a8614ab4fdf2964b3a3
ToppCell	343B-Lymphocytic-CD4_T-cell\|343B / Donor, Lineage, Cell class and subclass (all cells)	RPS12 RPS14 RCAN3 STK4 JAK3 CD2 CD28 ARID5B	2.10e-08	186	110	8	f6743d1f1d57d9d9a4581a88f156078a1da46816
ToppCell	T_cells-Central_memory_CD4+_T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	CFH ANO9 RPS12 VSIG1 RCAN3 OSM CD2 CD28	2.79e-08	193	110	8	725326d7e3604736b607c19f4069c81cb4f2d20c
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ANO9 RPS12 RPS14 RCAN3 CCND3 STK4 CD2 CD28	2.91e-08	194	110	8	cebd6767a1bd656aac2304d29cbbc164850562cc
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_T-T4_em-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CFH RPS12 RPS14 RCAN3 CD2 CD28 ARID5B UTY	3.03e-08	195	110	8	48905d57775ec90cc031af0863cc8c3800f2e48e
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_T-T4_reg-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	NLGN4Y RPS12 RHOXF1 RCAN3 CD2 CD28 ARID5B UTY	3.03e-08	195	110	8	911a37684c1f93d537f51ee71cb1ccec06840315
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ARID4B MCMDC2 RCAN3 STK4 JAK3 CD2 CD28 ARID5B	3.28e-08	197	110	8	ef2d1f56acd0be43e69bba7f73f6909ba87f1cb3
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4\|bone_marrow / Manually curated celltypes from each tissue	RPS12 RPS14 VSIG1 RCAN3 JAK3 CD2 CD28 ARID5B	3.41e-08	198	110	8	f2d85d7ca0e867d20ad4d2b1cbbfd91a066c1a03
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ARID4B MCMDC2 RCAN3 STK4 JAK3 CD2 CD28 ARID5B	3.41e-08	198	110	8	33a3b279c9ff3b762e52d060dae062167ca2239b
ToppCell	normal-na-Lymphocytic_T-T4_reg-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	ARID4B RCAN3 STK4 CD2 CD28 ARID5B UTY	1.67e-07	163	110	7	43887e7687fc6367efac0c1f56a9534b06f47b7f
ToppCell	COPD-Lymphoid-T_Regulatory\|World / Disease state, Lineage and Cell class	ARID4B STK4 CD2 CD28 ARID5B PPP1R16B SMYD3	3.28e-07	180	110	7	51a12fbad5fa7bb12e6d616a02ff9b5141e2b063
ToppCell	mild-Lymphocytic-CD4_T_cells_3\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	RPS12 RPS14 VSIG1 RCAN3 CD2 CD28 ARID5B	3.67e-07	183	110	7	61688846d398fbf086ea66a7b88cdf632f9d8c25
ToppCell	nucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-Treg\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DENND4A RCAN3 JAK3 CD2 CD28 ARID5B PPP1R16B	3.95e-07	185	110	7	a86a3a1a187a4d8d7762bc6d3dcb22c982178d22
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	MON2 DENND4A ARID4B USP24 BRAF SUCO KDM6A	4.40e-07	188	110	7	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	severe_influenza-CD4+_Tcm\|severe_influenza / disease group, cell group and cell class (v2)	ANO9 RPS12 RCAN3 CD2 CD28 ARID5B PPP1R16B	4.40e-07	188	110	7	633e5545f49b1b864b0ffa5fc9688d270690f884
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RCAN3 CCND3 STK4 JAK3 CD2 CD28 PPP1R16B	4.56e-07	189	110	7	df30478b288084a1bd48f660409dcc784040897c
ToppCell	343B-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell\|343B / Donor, Lineage, Cell class and subclass (all cells)	RPS12 RPS14 RCAN3 JAK3 CD2 CD28 ARID5B	4.90e-07	191	110	7	0583a0db58197af609ae251dcf882fc48cd6c897
ToppCell	390C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell\|390C / Donor, Lineage, Cell class and subclass (all cells)	RPS12 RPS14 RCAN3 STK4 CD2 CD28 ARID5B	5.07e-07	192	110	7	494c5eca0f07fc761f26487a2b937c7056bbe594
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	MON2 DENND4A ARID4B JAK3 BRAF KDM6A UTY	5.07e-07	192	110	7	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	356C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell\|356C / Donor, Lineage, Cell class and subclass (all cells)	RPS12 RPS14 RCAN3 STK4 CD2 CD28 ARID5B	5.07e-07	192	110	7	7aa8585e08dfbee0acbaef5f8f3817ab3ab5af25
ToppCell	Healthy_Control-Lymphoid-T-CCR7+_T\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	RPS12 RCAN3 JAK3 CD2 CD28 ARID5B PPP1R16B	5.07e-07	192	110	7	5b197f65a87c315e4f50c77a7fdec3b342a863ad
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MCMDC2 RCAN3 CCND3 STK4 CD2 CD28 ARID5B	5.07e-07	192	110	7	348d39da3016dc6dbfa65d108e5def35aa7f19dd
ToppCell	356C-Lymphocytic-CD4_T-cell\|356C / Donor, Lineage, Cell class and subclass (all cells)	RPS12 RPS14 RCAN3 STK4 CD2 CD28 ARID5B	5.07e-07	192	110	7	badf72a52eafb0269391d907ece6b1696684adce
ToppCell	Control-Lymphoid-T\|Control / Disease state, Lineage and Cell class	DENND4A CCND3 STK4 JAK3 CD2 CD28 PPP1R16B	5.25e-07	193	110	7	af928046ccd1ca874be1534aef6ca7f27d90bc46
ToppCell	Healthy_donor-CD4+_Tcm\|Healthy_donor / disease group, cell group and cell class (v2)	CFH RPS12 RPS14 RCAN3 CD2 CD28 ARID5B	5.25e-07	193	110	7	c16cdd6b439cb8dec228887662ba93d9c7894524
ToppCell	nucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-CD4_T\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	DENND4A STK4 JAK3 CD2 POLR3E CD28 PPP1R16B	5.25e-07	193	110	7	9c9434a3297b85774b4f0ecab6294f44d738e29f
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RCAN3 CCND3 STK4 JAK3 CD2 CD28 PPP1R16B	5.25e-07	193	110	7	b9769b45125d2244afe53f9f71c92c04ddccf980
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RCAN3 CCND3 STK4 JAK3 CD2 CD28 PPP1R16B	5.44e-07	194	110	7	3d6f2d190dd50804afea299957cc44c2bb756134
ToppCell	mild_COVID-19-CD4+_Tcm\|mild_COVID-19 / disease group, cell group and cell class (v2)	RPS12 RPS14 RCAN3 CD2 POLR3E CD28 ARID5B	5.44e-07	194	110	7	cf085813138a73878f9586059cd1d01d1a7ee748
ToppCell	Immune-T_lymphocyte\|World / Lineage, Cell type, age group and donor	RCAN3 CCND3 STK4 JAK3 CD2 CD28 PPP1R16B	5.44e-07	194	110	7	f47fa18c87b35a3960557f8169ff7830dd6ecb80
ToppCell	normal_Lung-T/NK_cells-CD4+_Th\|normal_Lung / Location, Cell class and cell subclass	RPS12 RPS14 RCAN3 STK4 CD2 CD28 ARID5B	5.63e-07	195	110	7	d6c69f149f3d96fe83f920e38277dede102d04b5
ToppCell	mild_COVID-19_(asymptomatic)-CD4+_Tcm\|World / disease group, cell group and cell class (v2)	CFH VSIG1 RCAN3 CD2 CD28 ARID5B PPP1R16B	5.63e-07	195	110	7	a72bb5b1b15dd1ab70ced5622d94499caff8bb6b
ToppCell	COVID-19_Moderate-CD4+_T_naive\|World / disease group, cell group and cell class	RPS12 RPS14 VSIG1 RCAN3 CD2 CD28 ARID5B	5.63e-07	195	110	7	38d65cf0895f7a99d789ec3dcbd56a7506706d38
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-T_cells-SELL+_CD4_T\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RPS12 RPS14 RCAN3 STK4 JAK3 CD2 CD28	5.63e-07	195	110	7	8ae2886dd4cfc70c58b61fbb6994f0a22f8c9127
ToppCell	COPD-Lymphoid-T\|COPD / Disease state, Lineage and Cell class	RCAN3 STK4 CD2 POLR3E CD28 ARID5B PPP1R16B	5.83e-07	196	110	7	30e53b8050d2a041f855d0e39bbd8f923c64c489
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-lymphocytic-T_lymphocytic-CD4-positive,_alpha-beta_T_cell\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RPS12 RPS14 VSIG1 RCAN3 CCND3 CD2 CD28	5.83e-07	196	110	7	6bf68f7b7c5f40b4bccb40deff10b4194d114ece
ToppCell	Multiple_Sclerosis-Lymphocyte-T_NK-CD4_TCM\|Multiple_Sclerosis / Disease, Lineage and Cell Type	RPS12 RPS14 RCAN3 STK4 CD2 CD28 ARID5B	5.83e-07	196	110	7	30c31f3d2c1fb3667c5c7f2057eca067dcd69e4d
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_T-T4_em-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CFH RPS12 RPS14 RCAN3 CD2 CD28 ARID5B	5.83e-07	196	110	7	ea3caea65e8ddd20a837b4322e7940328c94c15a
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_T-T4_em\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CFH RPS12 RPS14 RCAN3 CD2 CD28 ARID5B	5.83e-07	196	110	7	f7af0af02059aefb968b72a2a27867ad8ff23614
ToppCell	5'-Adult-LymphNode-Hematopoietic-T_cells-Treg\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RPS12 RCAN3 CCND3 STK4 CD2 CD28 ARID5B	6.03e-07	197	110	7	a6eba89bb3e24ae973068f85a8bcc3094e985cb9
ToppCell	10x5'-Liver-Lymphocytic_T_CD4\|Liver / Manually curated celltypes from each tissue	ANO9 VSIG1 RCAN3 JAK3 CD2 CD28 ARID5B	6.03e-07	197	110	7	4891111894b741555f549deec6af8006376d9358
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-Tfh\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RPS12 RPS14 CCND3 STK4 CD2 CD28 ARID5B	6.03e-07	197	110	7	144ca23372b3265007a1e508e48d320581cf5695
ToppCell	distal-Hematologic-CD4+_Memory/Effector_T-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ANO9 RPS12 RCAN3 STK4 CD2 CD28 ARID5B	6.24e-07	198	110	7	7a89635f3567b4d2e6cd684c47be2e015d72a357
ToppCell	COVID_vent-Lymphocytic-T_cell-CD4+_Memory_T_cell\|COVID_vent / Disease condition, Lineage, Cell class and subclass	RPS12 RPS14 VSIG1 RCAN3 CD2 CD28 ARID5B	6.24e-07	198	110	7	58f208b76cb0adcecdf632d92f92833a06f9bf71
ToppCell	Influenza-Influenza_Severe-Lymphocyte-T/NK-Treg\|Influenza_Severe / Disease, condition lineage and cell class	ANO9 DUS4L RHOXF1 RCAN3 CD28 ARID5B MCF2L	6.24e-07	198	110	7	e377fa0215f338f86ee2903ce3fa57cea805a630
ToppCell	control-Lymphocytic-CD4_T_cells_3\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	RPS12 RPS14 VSIG1 RCAN3 CD2 CD28 ARID5B	6.24e-07	198	110	7	667b2a046c9db3be2f2855f658343a56ad9ad32d
ToppCell	Influenza-Influenza_Severe-Lymphocyte-T/NK-CD4+_Tcm\|Influenza_Severe / Disease, condition lineage and cell class	CFH ANO9 RPS12 RCAN3 CD2 CD28 ARID5B	6.24e-07	198	110	7	fc99f2e300d76126d05c0c43e11cdbbeb74f6f0d
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD4-T_reg\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	VSIG1 RCAN3 STK4 JAK3 CD2 CD28 PPP1R16B	6.24e-07	198	110	7	7608f67959e1cda7b10e57fd3af2f96216ebe7e9
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RPS12 RPS14 RCAN3 CCND3 CD2 CD28 RAB27A	6.45e-07	199	110	7	33b69b7b1542cc826380cb4f2629c422b7f85c9a
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-Teffector/EM_CD4\|bone_marrow / Manually curated celltypes from each tissue	RPS12 RPS14 VSIG1 RCAN3 CD2 CD28 ARID5B	6.45e-07	199	110	7	e0c01ce4301f8446d990180ec336593ef0148b38
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	MON2 ACACA NBAS UBR3 KDM6A UTY SMYD3	6.45e-07	199	110	7	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	5'-Adult-LymphNode-Hematopoietic-T_cells-SELL+_CD4_T\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RPS12 RPS14 RCAN3 CCND3 STK4 CD2 CD28	6.45e-07	199	110	7	1b5b68f39102c607ae557a261c4e163b39d0c386
ToppCell	5'-Adult-LymphNode-Hematopoietic-T_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RPS12 RPS14 RCAN3 CCND3 STK4 CD2 CD28	6.67e-07	200	110	7	cf4d184ff07862fabb182dabf09b2c9aac491409
ToppCell	PBMC-Severe-Lymphocyte-T/NK\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	RPS12 RPS14 RCAN3 CD2 CD28 ARID5B HSP90AA1	6.67e-07	200	110	7	73b91cb66c375b44e852404a4a445cf2b9595aee
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK\|COVID-19_Severe / Disease, condition lineage and cell class	RPS12 RPS14 RCAN3 CD2 CD28 ARID5B HSP90AA1	6.67e-07	200	110	7	323cb89add511fbe9896b4df0f1f2b7fdbb6c649
ToppCell	COVID-19_Severe-Lymphoid_T/NK\|COVID-19_Severe / Disease group, lineage and cell class	RPS12 RPS14 RCAN3 CD2 CD28 ARID5B HSP90AA1	6.67e-07	200	110	7	9fc818bf5c9133fc2fece47980e71fd3f8603558
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-T-T_CD4-CD4_naive/CM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RCAN3 CCND3 STK4 JAK3 CD2 CD28 PPP1R16B	6.67e-07	200	110	7	e0cec0a844b7c1f8edee4c005af27766754e470a
ToppCell	MS-Multiple_Sclerosis-Lymphocyte-T/NK-CD4+_Tcm\|Multiple_Sclerosis / Disease, condition lineage and cell class	RPS12 RPS14 RCAN3 STK4 CD2 CD28 ARID5B	6.67e-07	200	110	7	33546f8d533c7e7ebd29b917b868352fb5bf24a9
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-T_cells-Activated_CD4_T\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RPS12 RPS14 RCAN3 CCND3 STK4 CD2 CD28	6.67e-07	200	110	7	80b35d808b26ca5021cbadbef523457ca789cd20
ToppCell	PBMC-Severe-Lymphocyte-T/NK\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RPS12 RPS14 RCAN3 CD2 CD28 ARID5B HSP90AA1	6.67e-07	200	110	7	f1c8780d64b58b6fb84fffbc27f0ad337b1a6e56
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_naive\|COVID-19_Mild / Disease, condition lineage and cell class	RPS12 RPS14 VSIG1 RCAN3 CD2 CD28 ARID5B	6.67e-07	200	110	7	a51b61afc3fd2e548489901a86fb9d1c5bd3f95f
ToppCell	ICU-SEP-Lymphocyte-T_NK-Treg\|ICU-SEP / Disease, Lineage and Cell Type	ATP8A2 RHOXF1 MCMDC2 CD2 ARID5B PPP1R16B	1.64e-06	145	110	6	ee99b58462f955b96d036aa67e343db047d66f64
ToppCell	ICU-SEP-Lymphocyte-T_NK-CD4_TEM\|ICU-SEP / Disease, Lineage and Cell Type	CFH RPS12 RPS14 RCAN3 STK4 CD2	3.01e-06	161	110	6	ae6c9afc3c928124993686a82d37d23138322bc1
ToppCell	COVID-19_Moderate-Treg\|COVID-19_Moderate / disease group, cell group and cell class	GRID1 RHOXF1 RCAN3 CD2 CD28 ARID5B	3.72e-06	167	110	6	4ddb21421cbe72c06b61dd3a5eb1337e59de42e5
ToppCell	Control-T_cells-Tregs\|Control / group, cell type (main and fine annotations)	RCAN3 STK4 JAK3 CD2 CD28 PPP1R16B	3.98e-06	169	110	6	e1e0983f31ec81b3fad5f9c6140d17f03f81a5dc
ToppCell	390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|390C / Donor, Lineage, Cell class and subclass (all cells)	ANO9 RCAN3 STK4 CD2 ARID5B PARPBP	3.98e-06	169	110	6	cfc9ff103d13a2d5eacc457e800f53fdd29f7738
ToppCell	COVID-19_Moderate-Treg\|World / disease group, cell group and cell class	GRID1 RHOXF1 RCAN3 CD2 CD28 ARID5B	3.98e-06	169	110	6	27ad11239559b025bef582f89b2a83501d9d3993
ToppCell	Influenza_Severe-CD4+_Tcm\|Influenza_Severe / Disease group and Cell class	CFH ANO9 RCAN3 CD2 CD28 ARID5B	4.41e-06	172	110	6	47865a04968ca28c6ff125159d9a23e37c8b8af1
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MCMDC2 RCAN3 CCND3 STK4 CD2 CD28	4.87e-06	175	110	6	f456d8d958b71f7a942b718605712593d9de1bfd
ToppCell	facs-GAT-Fat-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP8A2 RPS14 MSH4 CD2 CD28 RAB27A	5.03e-06	176	110	6	acd05ca8952710feedbfe377b1330f3c2406d044
ToppCell	10x3'2.3-week_14-16-Lymphocytic_T-T_NK-Treg\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ANO9 VSIG1 MSH4 RCAN3 CD2 CD28	5.03e-06	176	110	6	2eb1827171e9c19f945e87824215721f8cf22258
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NEDD9 ARID5B PPP1R16B MAP3K11 MCF2L POLQ	5.37e-06	178	110	6	ba2f0585626988b511046630bc16be5c5fec3fb2
ToppCell	normal-na-Lymphocytic_T-CD4-positive,_alpha-beta_T_cell-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	RPS12 RPS14 RCAN3 CD2 CD28 UTY	5.37e-06	178	110	6	fa3585383a1e7da460c88a802aaa81246d681b6b
ToppCell	URO-Lymphocyte-T_NK-CD4_TCM\|URO / Disease, Lineage and Cell Type	RPS12 RPS14 RCAN3 CD2 CD28 ARID5B	5.54e-06	179	110	6	cdf972acf23c7a22c99a336ee0f9cc51e0fa6f67
ToppCell	Control-Lymphoid-T_Regulatory\|World / Disease state, Lineage and Cell class	RCAN3 JAK3 CD2 CD28 ARID5B PPP1R16B	5.72e-06	180	110	6	47036eee4c128fbb443d1fc767b4de5cced93f0e
ToppCell	COVID-19-T_cells-Tregs\|COVID-19 / group, cell type (main and fine annotations)	STK4 JAK3 CD2 CD28 ARID5B PPP1R16B	5.91e-06	181	110	6	534659cf754326c6a73c0daa30e9d610612a0292
ToppCell	367C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	RPS12 RPS14 RCAN3 STK4 CD2 CD28	5.91e-06	181	110	6	9b155a74e68e485039a5195144a12833f2f75058
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-SELL+_CD4_T\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RPS12 RPS14 CCND3 JAK3 CD2 CD28	5.91e-06	181	110	6	04ed65362737e3e70134342127a3f4134a0e2eef
ToppCell	Healthy-CD8+_T_naive\|World / disease group, cell group and cell class	RPS12 RPS14 VSIG1 YIPF7 RCAN3 CD2	6.10e-06	182	110	6	b7d9f02c29c92c8803e11f967ad6eea032cb4224
ToppCell	Control-Lymphoid-T_Regulatory\|Control / Disease state, Lineage and Cell class	RCAN3 JAK3 CD2 CD28 ARID5B PPP1R16B	6.10e-06	182	110	6	31bb838cc2900f3c9da9f835d79d557a08abb928
ToppCell	tumor_Lung-Fibroblasts-Mesothelial_cells\|tumor_Lung / Location, Cell class and cell subclass	CFH VGLL3 BNC1 HP PTPRQ WNK4	6.49e-06	184	110	6	b0a251030d127858e68cf164be158f209a4d720f
ToppCell	Control-Lymphocyte-T_NK-CD4_TEM\|Control / Disease, Lineage and Cell Type	CFH RPS12 RPS14 RCAN3 CD2 CD28	6.70e-06	185	110	6	8d6a089dcb4bfb0e74b6316fb7221688c1835e6e
ToppCell	COPD-Epithelial-Mesothelial\|World / Disease state, Lineage and Cell class	CFH ROR1 BNC1 HP PTPRQ CFAP69	6.70e-06	185	110	6	23579988036fc1925992c31919750f9b3fe9f790
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RCAN3 CCND3 STK4 CD2 CD28 PPP1R16B	6.90e-06	186	110	6	9d576dce2c5deefef1adda16c6da7055c8d57f8f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RCAN3 CCND3 STK4 CD2 CD28 PPP1R16B	6.90e-06	186	110	6	bd3bd022b575d9b0ef90d50a5cb874085a827b77
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4-Tnaive/CM_CD4\|Lung / Manually curated celltypes from each tissue	RPS12 RPS14 RCAN3 CD2 CD28 ARID5B	6.90e-06	186	110	6	c67f373ba60e8d1ab70dfacc711ee440eaff6fb3
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-T_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RCAN3 CCND3 STK4 CD2 CD28 PPP1R16B	6.90e-06	186	110	6	924cc357b4c4ce8e9b05773bdab544f0b65474cc
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-Tnaive/CM_CD4_activated\|bone_marrow / Manually curated celltypes from each tissue	RPS12 RPS14 RCAN3 JAK3 CD2 HSP90AA1	6.90e-06	186	110	6	5108d9b7a081876ca34594b110d58df56063f542
ToppCell	Control-Lymphocyte-T_NK-CD4_TCM\|Control / Disease, Lineage and Cell Type	RPS12 RPS14 RCAN3 CD2 CD28 ARID5B	7.12e-06	187	110	6	1de80f40f753b31aed1fac9f3ff8a2ee6c755eec
ToppCell	ICU-NoSEP-Lymphocyte-T_NK-CD4_TCM\|ICU-NoSEP / Disease, Lineage and Cell Type	RPS12 RPS14 RCAN3 CD2 CD28 ARID5B	7.12e-06	187	110	6	9856e0ddf989707e2a25ed6ab75bd9fa939c9046
ToppCell	Int-URO-Lymphocyte-T_NK-CD4_TCM\|Int-URO / Disease, Lineage and Cell Type	RPS12 RPS14 RCAN3 CD2 CD28 ARID5B	7.12e-06	187	110	6	9a137961d33c6b440f1e5ef40360a365e3c03ab2
ToppCell	mild_COVID-19-CD8+_T_naive\|World / disease group, cell group and cell class (v2)	ATP8A2 RPS12 RPS14 VSIG1 RCAN3 CD28	7.34e-06	188	110	6	ddfb1c64305825fb0bc23819aa001bfc2ac4c2b2
ToppCell	COVID-19-kidney-T-cells-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	STK4 CD2 CD28 PPP1R16B POLQ HSP90AA1	7.34e-06	188	110	6	15484c05cb496cd98ed3f79a6134c5cec8f09a4d
ToppCell	COPD-Epithelial-Mesothelial\|COPD / Disease state, Lineage and Cell class	CFH ROR1 BNC1 HP PTPRQ CFAP69	7.57e-06	189	110	6	79bb2593ad5d17f94b17972884241f03a0f43770
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Undetermined\|Myeloid_cells / Location, Cell class and cell subclass	ENPP3 RPS12 RPS14 NDRG2 HP SMYD3	7.57e-06	189	110	6	b46adb47768a7b6d801c457d7ba65508edfc36a5
ToppCell	Bac-SEP-Lymphocyte-T_NK-CD4_TCM\|Bac-SEP / Disease, Lineage and Cell Type	RPS12 RPS14 RCAN3 CD2 CD28 ARID5B	7.57e-06	189	110	6	70f918dc208cd7ce8de9007729d8c5743c56c130
ToppCell	COVID-19-T_cells-CD8+_T_cells\|COVID-19 / group, cell type (main and fine annotations)	CCND3 STK4 JAK3 CD2 CD28 PPP1R16B	7.57e-06	189	110	6	2c018d6120f65f0b2704b483bc9da1c0984872e3
ToppCell	severe_COVID-19-CD4+_Tcm\|World / disease group, cell group and cell class (v2)	CFH RPS12 RCAN3 CD2 CD28 ARID5B	7.57e-06	189	110	6	8037fd4d799d95d9ca633a3efaf698539f696893
Disease	Kabuki syndrome (implicated_via_orthology)	KDM6A UTY	4.12e-05	3	110	2	DOID:0060473 (implicated_via_orthology)
Disease	tensin-2 measurement	CFH STK4	4.12e-05	3	110	2	EFO_0802122
Disease	Malignant Neoplasms	APC CCND1 CCND3 BRAF KDM6A	1.21e-04	128	110	5	C0006826
Disease	rheumatoid arthritis (is_marker_for)	LRRK2 CD28 LPA HSP90AA1	1.31e-04	69	110	4	DOID:7148 (is_marker_for)
Disease	Intestinal Polyps	APC CCND1	1.37e-04	5	110	2	C0021846
Disease	muscular disease (implicated_via_orthology)	ACACA ACACB	1.37e-04	5	110	2	DOID:0080000 (implicated_via_orthology)
Disease	Colorectal cancer	APC CCND1 BRAF	1.38e-04	27	110	3	cv:C0346629
Disease	COLORECTAL CANCER	APC CCND1 BRAF	1.38e-04	27	110	3	114500
Disease	Neoplasm of the large intestine	APC CCND1 BRAF	1.38e-04	27	110	3	cv:C0009404
Disease	galectin-7 measurement	CFH STK4	2.05e-04	6	110	2	EFO_0022034
Disease	interleukin-23 receptor measurement	CFH STK4	2.05e-04	6	110	2	EFO_0801725
Disease	Ovarian Mucinous Adenocarcinoma	ROR1 LRRK2 WNK4	2.10e-04	31	110	3	C1335167
Disease	bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 measurement	CFH RPS14	2.86e-04	7	110	2	EFO_0802332
Disease	r-spondin-3 measurement	CFH STK4	2.86e-04	7	110	2	EFO_0021878
Disease	Malignant tumor of colon	APC CCND1 NDRG2 BRAF SLC22A1	3.31e-04	159	110	5	C0007102
Disease	Multiple Myeloma	CCND1 BRAF KDM6A	5.21e-04	42	110	3	C0026764
Disease	Adenoid Cystic Carcinoma	ARID4B CCND1 ARID5B KDM6A	5.44e-04	100	110	4	C0010606
Disease	cholesterol to total lipids in large VLDL percentage	LPA SLC22A1 SAMM50	6.38e-04	45	110	3	EFO_0022236
Disease	cholesteryl ester measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	ACACB FDFT1 LPA SLC22A1	7.79e-04	110	110	4	EFO_0008317, EFO_0008596, EFO_0010351
Disease	chylomicron measurement, total cholesterol measurement, very low density lipoprotein cholesterol measurement	ACACB FDFT1 LPA SLC22A1	7.79e-04	110	110	4	EFO_0004574, EFO_0008317, EFO_0008596
Disease	serum metabolite measurement	PDE8A ABCA7 CDK10 SH3BP4 CCND3 TREH SLC22A1 FSHR ARID5B MYOM2 MEGF11	8.17e-04	945	110	11	EFO_0005653
Disease	pancreatic cancer (is_implicated_in)	APC CCND1 LIG3 BRAF	8.33e-04	112	110	4	DOID:1793 (is_implicated_in)
Disease	daytime rest measurement	ACACA LRRK2 APC MSH4 FSHR SUCO	8.52e-04	295	110	6	EFO_0007828
Disease	gout	GRID1 SLC22A1 ARID5B MAP3K11 SMYD3	8.56e-04	196	110	5	EFO_0004274
Disease	endometrial carcinoma (is_implicated_in)	APC BRAF	8.87e-04	12	110	2	DOID:2871 (is_implicated_in)
Disease	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	CCND3 JAK3 KDM6A	1.03e-03	53	110	3	C1961099
Disease	Heschl's gyrus morphology measurement	NEDD9 CD28 MYOM2	1.03e-03	53	110	3	EFO_0005852
Disease	colorectal cancer (is_implicated_in)	APC CCND1 BRAF KDM6A	1.11e-03	121	110	4	DOID:9256 (is_implicated_in)
Disease	leukemia	CCND1 BRAF HP	1.15e-03	55	110	3	C0023418
Disease	Replication Error Phenotype	BRAF HDAC2	1.40e-03	15	110	2	C1721098
Disease	caffeine measurement	LRRK2 MEGF11	1.40e-03	15	110	2	EFO_0021177
Disease	quinate measurement	LRRK2 GRID1	1.40e-03	15	110	2	EFO_0021167
Disease	Microsatellite Instability	BRAF HDAC2	1.40e-03	15	110	2	C0920269
Disease	triglycerides to total lipids in chylomicrons and extremely large VLDL percentage	LPA SLC22A1	1.40e-03	15	110	2	EFO_0022328
Disease	ankle brachial index	NBAS LPA	1.60e-03	16	110	2	EFO_0003912
Disease	pulmonary hypertension (is_marker_for)	HP CD28 HDAC2	1.78e-03	64	110	3	DOID:6432 (is_marker_for)
Disease	Benign neoplasm of stomach	APC BRAF	1.81e-03	17	110	2	C0153943
Disease	Eye Abnormalities	APC FREM1	1.81e-03	17	110	2	C0015393
Disease	Neoplasm of uncertain or unknown behavior of stomach	APC BRAF	1.81e-03	17	110	2	C0496905
Disease	Carcinoma in situ of stomach	APC BRAF	1.81e-03	17	110	2	C0154060
Disease	cholesterol to total lipids in chylomicrons and extremely large VLDL percentage	LPA SLC22A1	1.81e-03	17	110	2	EFO_0022232
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	ACACA ACACB HP	1.86e-03	65	110	3	DOID:0080208 (biomarker_via_orthology)
Disease	urate measurement, bone density	UBE4B GRID1 FREM1 NEDD9 POLR3E ARID5B PPP1R16B MEGF11	2.26e-03	619	110	8	EFO_0003923, EFO_0004531
Disease	Pancreatic carcinoma	APC BRAF	2.26e-03	19	110	2	C0235974
Disease	melanoma	CCND1 CUBN BRAF PTPRK HDAC2	2.41e-03	248	110	5	C0025202
Disease	stomach cancer (is_implicated_in)	APC KDM6A HDAC2	2.49e-03	72	110	3	DOID:10534 (is_implicated_in)
Disease	glaucoma (is_marker_for)	CFH HEPH	2.50e-03	20	110	2	DOID:1686 (is_marker_for)
Disease	urinary microalbumin measurement	MON2 CUBN	2.50e-03	20	110	2	EFO_0010967
Disease	coagulation factor measurement	CFH MCF2L	2.50e-03	20	110	2	EFO_0004634
Disease	atherosclerosis (biomarker_via_orthology)	CCND1 HP	2.50e-03	20	110	2	DOID:1936 (biomarker_via_orthology)
Disease	Adenocarcinoma of prostate	BRAF HDAC2	2.50e-03	20	110	2	C0007112
Disease	Colonic Neoplasms	APC CCND1 NDRG2 SLC22A1	2.56e-03	152	110	4	C0009375
Disease	Stomach Carcinoma	APC BRAF	2.76e-03	21	110	2	C0699791
Disease	cholesteryl esters to total lipids in chylomicrons and extremely large VLDL percentage	LPA SLC22A1	2.76e-03	21	110	2	EFO_0022246
Disease	Amphetamine-Related Disorders	CUBN MTARC2 SMYD3	2.80e-03	75	110	3	C0236733
Disease	Amphetamine Abuse	CUBN MTARC2 SMYD3	2.80e-03	75	110	3	C0236807
Disease	Amphetamine Addiction	CUBN MTARC2 SMYD3	2.80e-03	75	110	3	C0236804
Disease	Liver carcinoma	ACACA APC CCND1 BRAF FDFT1 LPA SLC22A1	2.95e-03	507	110	7	C2239176
Disease	cholangiocarcinoma (is_implicated_in)	APC BRAF	3.03e-03	22	110	2	DOID:4947 (is_implicated_in)
Disease	complement factor H-like 1 protein measurement	CFH ATP8A2	3.03e-03	22	110	2	EFO_0600092
Disease	Granulomatous Slack Skin	BRAF CD28	3.03e-03	22	110	2	C0376407
Disease	hemoglobin measurement, mean corpuscular hemoglobin	DENND4A CCND3	3.03e-03	22	110	2	EFO_0004509, EFO_0004527
Disease	Immunologic Deficiency Syndromes	CFH NBAS	3.31e-03	23	110	2	C0021051
Disease	Lymphoma, T-Cell, Cutaneous	BRAF CD28	3.31e-03	23	110	2	C0079773

Protein segments in the cluster

Peptide	Gene	Start	Entry
YNMIEICLNPDNETV	TTC21B	1061	Q7Z4L5
YCRSANIEFQMALPE	ARID4B	396	Q4LE39
VVLVNYPLLDMAAAA	ERFL	126	A0A1W2PQ73
VPLMCVNYDQLDLLF	BRAF	276	P15056
QRCEEEVFPLAMNYL	CCND3	71	P30281
ANMKCPQIVIAFYEE	CBX3	156	Q13185
LMARALYDNVPECAE	NEDD9	6	Q14511
SPMLVAYDNAVNLSC	CD28	26	P10747
CEVMNGTDPELNLYQ	CD2	146	P06729
YPICVLMEKADQSLA	BNC1	906	Q01954
VLDNLVNVMNGYCLP	ACACA	856	Q13085
QKCEEEVFPLAMNYL	CCND1	71	P24385
PCVISREIMENYNIA	CFH	1166	P08603
LSAAIDCLEYLPDQM	DEPDC7	266	Q96QD5
YKAQPVIQFMCEVLD	AGO3	226	Q9H9G7
EEMALQLINCPDYKL	ANO9	306	A1A5B4
PQAMCYVETANLDGE	ATP8A2	196	Q9NTI2
CPQYNVLFDMLTVDE	ABCA7	886	Q8IZY2
LLYAMCDRSNAPQIV	AP2A2	391	O94973
LMQLCGQYDQPVLAV	DENND4A	816	Q7Z401
EDAMPVINYDLLCAV	RCAN3	161	Q9UKA8
QLQMHAYCENPDIVL	RAB27A	116	P51159
AACLALEMKYALDPN	INSYN2A	21	Q6ZSG2
ELALLIQQCMAYEPV	JAK3	751	P52333
LCVLYMENDLSEGVN	PARPBP	456	Q9NWS1
VIDATINPLCIEMYA	ACACB	2206	O00763
LLGCVFAIADYPEQM	PAXIP1	606	Q6ZW49
RCDQAALMMEELNPY	MEGF11	821	A6BM72
NQEVANFYCDIMPLL	OR1A2	171	Q9Y585
QMDCSLIPANLVEAF	MCMDC2	481	Q4G0Z9
LKYVMLPVADQDQCI	HP	296	P00738
PEIDNALVVFCMATY	POR	126	P16435
CEASAMLPLECQYLN	NELFA	131	Q9H3P2
YMEVNDGLCNLLIAP	FGR	226	P09769
AEANIAPMCLLANVA	KRT38	36	O76015
QNQPMDALQAYICAV	KDM6A	331	O15550
IPQVMAIATLAACYN	FDFT1	291	P37268
PFYDCRQAMSLEENL	PLXNB2	611	O15031
ENPNIMACYNELLQL	PDE8A	186	O60658
YLLEPDCNIIHMSNN	FREM1	126	Q5H8C1
CVNLLLEASNYQMMP	KLHL9	266	Q9P2J3
HTLQMYPDDQEIQCL	LRRK2	591	Q5S007
PEVLMQQGYDAACDI	RPS6KA6	591	Q9UK32
AYMLFQDLCQLVNAD	MON2	216	Q7Z3U7
PLLSYNVDVCLAVQM	PLEKHM3	401	Q6ZWE6
VQPMLAEACKSVEYA	LIG3	481	P49916
PDQDQLMAIALECIY	NBAS	986	A2RRP1
ALFSNPMDDNLICAV	PAIP1	306	Q9H074
EEIYIIGADNACMIP	PTPRQ	1881	Q9UMZ3
LAVNSDGNMPYDLCE	PPP1R16B	161	Q96T49
DQNEDCLYLNIYVPM	NLGN4Y	141	Q8NFZ3
LESMDNCPHEFLQVY	CUBN	521	O60494
DNNMNCTYVIEANPL	CUBN	2941	O60494
VELMAYENANPECQS	ERVK-10	476	P87889
VELMAYENANPECQS	ERVK-21	476	P62683
VELMAYENANPECQS	ERVK-24	476	P63145
ELMAYENANPECQSA	ERVK-5	476	Q9HDB9
VELMAYENANPECQS	ERVK-6	476	Q7LDI9
VELMAYENANPECQS	ERVK-7	476	P63130
VELMAYENANPECQS	ERVK-8	476	P62685
VELMAYENANPECQS	ERVK-9	476	P63126
VELMAYENANPECQS	HERVK_113	476	P62684
VMGYCEQDLASLLEN	CDK10	116	Q15131
PFENIEVYNLMCDLL	ENPP3	511	O14638
VEMPSQYCLALLELN	POLQ	2076	O75417
PQDVVCIDLDTNMLY	DENND4C	481	Q5VZ89
GLIMNYCRNPDAVAA	LPA	71	P08519
LIMNYCRNPDAVAAP	LPA	186	P08519
AGLIMNYCRNPDAVA	LPA	526	P08519
GLIMNYCRNPDAVAA	LPA	641	P08519
LIMNYCRNPDAVAAP	LPA	756	P08519
GLMCPAIDAVLVYVN	BPIFB6	171	Q8NFQ5
IIYENNCLIFRAPDM	MTARC2	116	Q969Z3
LCVLEGYAAEMDNPL	MCF2L	651	O15068
CDPQEGYLQMLQISN	GRID1	306	Q9ULK0
SLEDLYCCMPQLDAA	C2orf81	266	A6NN90
YGACLINKPELVQDM	DUS4L	126	O95620
MDNCEELIPEYLNFI	HSP90AA1	371	P07900
DAFNPCEDIMGYNIL	FSHR	351	P23945
EMYQPSAVVLQCGAD	HDAC2	251	Q92769
APLLIEEYMSCQGNA	CFAP69	431	A5D8W1
DCFYAQVEMISNPEL	POLI	61	Q9UNA4
NIARLELNYCVPMGV	SAMM50	436	Q9Y512
IQMICLVNAELYPTF	SLC22A1	446	O15245
VELEMAIDTLNPNYC	POLR3E	56	Q9NVU0
AVCLEEPNLCLVMEY	MAP3K11	181	Q16584
VMLNEVDLSQGCPQY	PTPRK	1271	Q15262
TLMVACLSPADNNYD	KIF17	306	Q9P2E2
YPFLLVGDLMAVNNC	MTCH1	326	Q9NZJ7
PMDALQAYICAVQLD	UTY	331	O14607
MLANELRADPDDCVY	RHOXF1	166	Q8NHV9
MAVCIAVIAKENYPL	TRAPPC2L	1	Q9UL33
FAAVAAANCINIPLM	SFXN3	181	Q9BWM7
DTVQAQLHNLEPCMY	SH3BP4	436	Q9P0V3
LDQLADMIPCVLQYL	NDRG2	121	Q9UN36
IMQPDNLGTFEIYCQ	HEPH	686	Q9BQS7
PYAAMLAAQDVAQRC	RPS14	71	P62263
ELCHIDALYPNVENM	MSH4	796	O15457
YCMAQLLDNSDTAEP	OSM	151	P13725
PDINIYQLKVLDCAM	SMYD3	321	Q9H7B4
VELMAYENANPECQS	ERVK-9	476	P63128
LPAMADYIANCTVKV	ARID5B	616	Q14865
AELLQVDCEMYGLTN	APC	476	P25054
QPVCMLFEYINQGDL	ROR1	546	Q01973
AAQMRPACEQIYNLF	PITPNM1	716	O00562
RLDECQMYLAHEQAP	ST6GALNAC4	256	Q9H4F1
MQPADSGIYICDVNN	VSIG1	106	Q86XK7
EASIVVNNPDLLMFC	PIGX	161	Q8TBF5
QALYEPCTQDIVMFL	UBE4B	901	O95155
PVDLNAFLCQAEELM	TREH	346	O43280
PEQRNLYKDVMLDNC	ZNF840P	61	A6NDX5
CESFLIPQLQNGDMY	ZNF654	281	Q8IZM8
EIYQEDQIHFMCPLA	TEX264	171	Q9Y6I9
VLASNCDEPMYVKLV	RPS12	51	P25398
INCLNAAIDIYTDMG	NAPB	101	Q9H115
NNLAACLLQMEPVNY	TTC9C	76	Q8N5M4
AILIENMDLYMLNPC	SUCO	331	Q9UBS9
LAMEGQQLLVAYPCA	YIPF5	231	Q969M3
MNYLQLYNVPDCLED	ZBTB1	101	Q9Y2K1
CAEYLNSSVVQPMLD	USP24	321	Q9UPU5
NSMIDPDIYLLQVCA	UBR3	706	Q6ZT12
MAPEVIQEIGYNCVA	STK4	191	Q13043
MEGQQLLVAYPCAIL	YIPF7	256	Q8N8F6
DQPAEMEYLNSRCVL	VGLL3	76	A8MV65
EMVALGLVCEADYQP	WNK4	491	Q96J92
PMDLQCHDANRDYVI	MYOM2	386	P54296