Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiongroup II metabotropic glutamate receptor activity

GRM2 GRM3

3.16e-062362GO:0001641
GeneOntologyMolecularFunctionextracellular matrix structural constituent

FBN1 FBN2 VWF MUC17 MUC5AC

2.09e-05188365GO:0005201
GeneOntologyMolecularFunctionG protein-coupled glutamate receptor activity

GRM2 GRM3

1.13e-049362GO:0098988
GeneOntologyMolecularFunctionadenylate cyclase inhibiting G protein-coupled glutamate receptor activity

GRM2 GRM3

1.13e-049362GO:0001640
GeneOntologyMolecularFunctionprotein domain specific binding

SCNN1A DOCK3 LRP2 SHC4 CRIM1 MUC17 AR UNC13A

1.33e-04875368GO:0019904
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

FBN1 FBN2

2.06e-0412362GO:0030023
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

FBN1 FBN2

2.84e-0414362GO:0097493
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

LRP2 STAB2

3.73e-0416362GO:0005041
GeneOntologyMolecularFunctionligand-gated sodium channel activity

SCNN1A ASIC1

4.75e-0418362GO:0015280
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

LRP2 STAB2

6.49e-0421362GO:0030228
GeneOntologyMolecularFunctionglutamate receptor activity

GRM2 GRM3

1.08e-0327362GO:0008066
GeneOntologyMolecularFunctionRNA polymerase II general transcription initiation factor binding

TAF1 AR

1.08e-0327362GO:0001091
GeneOntologyMolecularFunctionPDZ domain binding

LRP2 CRIM1 MUC17

1.40e-03123363GO:0030165
GeneOntologyMolecularFunctioncalcium ion binding

LRP2 FBN1 STAB2 FBN2 UNC13A SLIT3

2.03e-03749366GO:0005509
GeneOntologyMolecularFunctionsodium channel activity

SCNN1A ASIC1

3.96e-0352362GO:0005272
GeneOntologyMolecularFunctioncalcium channel regulator activity

GRM2 GRM3

4.26e-0354362GO:0005246
GeneOntologyMolecularFunctionnuclear receptor binding

LRP2 TAF1 AR

4.60e-03187363GO:0016922
GeneOntologyMolecularFunctiongeneral transcription initiation factor binding

TAF1 AR

5.94e-0364362GO:0140296
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

CRIM1 TEK

6.12e-0365362GO:0004714
GeneOntologyMolecularFunctionbasal RNA polymerase II transcription machinery binding

TAF1 AR

6.30e-0366362GO:0001099
GeneOntologyMolecularFunctionbasal transcription machinery binding

TAF1 AR

6.30e-0366362GO:0001098
GeneOntologyBiologicalProcessnegative regulation of adenylate cyclase activity

CCR2 GRM2 GRM3

3.28e-0618343GO:0007194
GeneOntologyBiologicalProcessnegative regulation of cyclase activity

CCR2 GRM2 GRM3

3.89e-0619343GO:0031280
GeneOntologyBiologicalProcessnegative regulation of lyase activity

CCR2 GRM2 GRM3

6.17e-0622343GO:0051350
GeneOntologyBiologicalProcessnegative regulation of BMP signaling pathway

LRP2 VWC2 FBN1 CRIM1

8.91e-0680344GO:0030514
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

DOCK3 LRP2 SHC4 VWC2 FBN1 FBN2 CRIM1 TEK ZYX AR

1.40e-0511863410GO:0007167
GeneOntologyBiologicalProcessregulation of synaptic transmission, glutamatergic

CCR2 GRM2 GRM3 UNC13A

1.55e-0592344GO:0051966
GeneOntologyBiologicalProcesssequestering of TGFbeta in extracellular matrix

FBN1 FBN2

1.58e-054342GO:0035583
GeneOntologyBiologicalProcessnegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

LRP2 VWC2 FBN1 FBN2 CRIM1

2.73e-05218345GO:0090101
GeneOntologyBiologicalProcessregulation of cellular response to growth factor stimulus

LRP2 VWC2 FBN1 FBN2 CRIM1 TEK

5.13e-05412346GO:0090287
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

DOCK3 LRP2 VWC2 FBN1 FBN2 CRIM1 TEK ZYX

5.63e-05850348GO:0071363
GeneOntologyBiologicalProcessregulation of BMP signaling pathway

LRP2 VWC2 FBN1 CRIM1

6.22e-05131344GO:0030510
GeneOntologyBiologicalProcesssynaptic transmission, glutamatergic

CCR2 GRM2 GRM3 UNC13A

6.40e-05132344GO:0035249
GeneOntologyBiologicalProcessmaintenance of protein location in extracellular region

FBN1 FBN2

7.34e-058342GO:0071694
GeneOntologyBiologicalProcessresponse to growth factor

DOCK3 LRP2 VWC2 FBN1 FBN2 CRIM1 TEK ZYX

7.36e-05883348GO:0070848
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

LRP2 VWC2 FBN1 FBN2 CRIM1 ZYX

7.85e-05445346GO:0141091
GeneOntologyBiologicalProcesssensory perception of sour taste

SCNN1A ASIC1

9.43e-059342GO:0050915
GeneOntologyBiologicalProcessadenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

GRM2 GRM3

9.43e-059342GO:0007196
GeneOntologyBiologicalProcessnegative regulation of cellular response to growth factor stimulus

LRP2 VWC2 FBN1 CRIM1

1.05e-04150344GO:0090288
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

LRP2 VWC2 FBN1 FBN2 CRIM1 ZYX

1.22e-04482346GO:0007178
GeneOntologyBiologicalProcessregulation of adenylate cyclase activity

CCR2 GRM2 GRM3

1.25e-0459343GO:0045761
GeneOntologyBiologicalProcessglutamate receptor signaling pathway

GRM2 GRM3 UNC13A

1.25e-0459343GO:0007215
GeneOntologyBiologicalProcesssequestering of extracellular ligand from receptor

FBN1 FBN2

1.44e-0411342GO:0035581
GeneOntologyBiologicalProcessregulation of cyclase activity

CCR2 GRM2 GRM3

1.99e-0469343GO:0031279
GeneOntologyBiologicalProcessextracellular regulation of signal transduction

FBN1 FBN2

2.03e-0413342GO:1900115
GeneOntologyBiologicalProcessextracellular negative regulation of signal transduction

FBN1 FBN2

2.03e-0413342GO:1900116
GeneOntologyBiologicalProcessregulation of lyase activity

CCR2 GRM2 GRM3

2.35e-0473343GO:0051339
GeneOntologyBiologicalProcessregulation of transmembrane receptor protein serine/threonine kinase signaling pathway

LRP2 VWC2 FBN1 FBN2 CRIM1

2.44e-04347345GO:0090092
GeneOntologyBiologicalProcessBMP signaling pathway

LRP2 VWC2 FBN1 CRIM1

2.99e-04197344GO:0030509
GeneOntologyBiologicalProcessG protein-coupled glutamate receptor signaling pathway

GRM2 GRM3

3.12e-0416342GO:0007216
GeneOntologyBiologicalProcessresponse to BMP

LRP2 VWC2 FBN1 CRIM1

4.17e-04215344GO:0071772
GeneOntologyBiologicalProcesscellular response to BMP stimulus

LRP2 VWC2 FBN1 CRIM1

4.17e-04215344GO:0071773
GeneOntologyBiologicalProcesscellular response to aldehyde

ADH5 SCNN1A

4.92e-0420342GO:0110096
GeneOntologyBiologicalProcesscellular response to pH

SCNN1A ASIC1

8.36e-0426342GO:0071467
GeneOntologyBiologicalProcessresponse to acidic pH

SCNN1A ASIC1

9.02e-0427342GO:0010447
GeneOntologyCellularComponentextracellular matrix

VWC2 FBN1 FBN2 FCGBP VWF MUC17 MUC5AC OTOGL

1.25e-05656368GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

VWC2 FBN1 FBN2 FCGBP VWF MUC17 MUC5AC OTOGL

1.28e-05658368GO:0030312
GeneOntologyCellularComponentmicrofibril

FBN1 FBN2

2.22e-0413362GO:0001527
GeneOntologyCellularComponentexternal side of plasma membrane

SCNN1A LRP2 CCR2 STAB2 VWF MUC17

2.35e-04519366GO:0009897
GeneOntologyCellularComponentsynaptic membrane

SHC4 VWC2 GRM2 GRM3 ASIC1 UNC13A

4.38e-04583366GO:0097060
GeneOntologyCellularComponentcell surface

SCNN1A LRP2 CCR2 STAB2 VWF TEK MUC17 ASIC1

4.95e-041111368GO:0009986
GeneOntologyCellularComponentpostsynaptic membrane

SHC4 VWC2 GRM2 GRM3 ASIC1

6.12e-04405365GO:0045211
GeneOntologyCellularComponentastrocyte projection

GRM2 GRM3

8.44e-0425362GO:0097449
GeneOntologyCellularComponentcollagen-containing extracellular matrix

VWC2 FBN1 FBN2 VWF MUC17

2.02e-03530365GO:0062023
GeneOntologyCellularComponentglial cell projection

GRM2 GRM3

2.97e-0347362GO:0097386
GeneOntologyCellularComponentdendrite

LRP2 CCR2 GRM2 GRM3 ASIC1 AR

3.19e-03858366GO:0030425
GeneOntologyCellularComponentdendritic tree

LRP2 CCR2 GRM2 GRM3 ASIC1 AR

3.23e-03860366GO:0097447
GeneOntologyCellularComponentside of membrane

SCNN1A LRP2 CCR2 STAB2 VWF MUC17

3.51e-03875366GO:0098552
HumanPhenoAbnormal upper to lower segment ratio

FBN1 FBN2

3.14e-053172HP:0012772
DomainVWC

VWC2 FCGBP VWF CRIM1 MUC5AC

8.24e-0938355SM00214
DomainEGF

LRP2 FBN1 STAB2 FBN2 FCGBP TEK MUC17 SLIT3

9.79e-09235358SM00181
DomainTIL_dom

LRP2 FCGBP VWF MUC5AC

1.02e-0814354IPR002919
DomainGrowth_fac_rcpt_

LRP2 FBN1 STAB2 FBN2 CRIM1 TEK SLIT3

1.37e-08156357IPR009030
DomainVWF_dom

VWC2 FCGBP VWF CRIM1 MUC5AC

1.39e-0842355IPR001007
DomainEGF-like_dom

LRP2 FBN1 STAB2 FBN2 FCGBP TEK MUC17 SLIT3

1.54e-08249358IPR000742
DomainVWC_out

FCGBP VWF CRIM1 MUC5AC

3.93e-0819354SM00215
DomainVWC

VWC2 VWF CRIM1 MUC5AC

2.05e-0728354PF00093
DomainEGF_3

LRP2 FBN1 STAB2 FBN2 TEK MUC17 SLIT3

2.27e-07235357PS50026
DomainEGF_1

LRP2 FBN1 STAB2 FBN2 TEK MUC17 SLIT3

3.95e-07255357PS00022
DomainEGF-like_CS

LRP2 FBN1 STAB2 FBN2 TEK MUC17 SLIT3

4.62e-07261357IPR013032
DomainEGF_2

LRP2 FBN1 STAB2 FBN2 TEK MUC17 SLIT3

5.12e-07265357PS01186
DomainVWFC_1

VWC2 VWF CRIM1 MUC5AC

5.83e-0736354PS01208
DomainVWFC_2

VWC2 VWF CRIM1 MUC5AC

7.29e-0738354PS50184
DomainTIL

FCGBP VWF MUC5AC

1.31e-0612353PF01826
DomainC8

FCGBP VWF MUC5AC

1.31e-0612353PF08742
DomainUnchr_dom_Cys-rich

FCGBP VWF MUC5AC

1.70e-0613353IPR014853
DomainC8

FCGBP VWF MUC5AC

1.70e-0613353SM00832
DomainEGF_CA

LRP2 FBN1 STAB2 FBN2 SLIT3

3.04e-06122355SM00179
DomainEGF-like_Ca-bd_dom

LRP2 FBN1 STAB2 FBN2 SLIT3

3.29e-06124355IPR001881
DomainVWFD

FCGBP VWF MUC5AC

3.32e-0616353PS51233
DomainVWD

FCGBP VWF MUC5AC

3.32e-0616353SM00216
DomainVWF_type-D

FCGBP VWF MUC5AC

3.32e-0616353IPR001846
DomainVWD

FCGBP VWF MUC5AC

3.32e-0616353PF00094
DomainCTCK_1

VWF MUC5AC SLIT3

4.83e-0618353PS01185
DomainCT

VWF MUC5AC SLIT3

9.06e-0622353SM00041
DomainFBN

FBN1 FBN2

1.02e-053352IPR011398
DomainCys_knot_C

VWF MUC5AC SLIT3

1.35e-0525353IPR006207
DomainCTCK_2

VWF MUC5AC SLIT3

1.35e-0525353PS01225
DomaincEGF

LRP2 FBN1 FBN2

1.52e-0526353IPR026823
DomaincEGF

LRP2 FBN1 FBN2

1.52e-0526353PF12662
DomainEGF_Ca-bd_CS

LRP2 FBN1 FBN2 SLIT3

3.16e-0597354IPR018097
DomainEGF_CA

LRP2 FBN1 FBN2 SLIT3

3.43e-0599354PS01187
DomainEGF-type_Asp/Asn_hydroxyl_site

LRP2 FBN1 FBN2 SLIT3

4.48e-05106354IPR000152
DomainENaC

SCNN1A ASIC1

7.12e-057352IPR004724
DomainTB

FBN1 FBN2

7.12e-057352PF00683
DomainHirudin/antistatin

CRIM1 MUC5AC

7.12e-057352IPR011061
Domain-

FBN1 FBN2

9.49e-0583523.90.290.10
DomainNa+channel_ASC_CS

SCNN1A ASIC1

9.49e-058352IPR020903
DomainGPCR_3_mtglu_rcpt

GRM2 GRM3

9.49e-058352IPR000162
DomainASC

SCNN1A ASIC1

1.22e-049352PF00858
DomainTB

FBN1 FBN2

1.22e-049352PS51364
DomainASC

SCNN1A ASIC1

1.22e-049352PS01206
DomainNa+channel_ASC

SCNN1A ASIC1

1.22e-049352IPR001873
DomainTB_dom

FBN1 FBN2

1.22e-049352IPR017878
DomainEGF_extracell

LRP2 STAB2 TEK

1.92e-0460353IPR013111
DomainEGF_2

LRP2 STAB2 TEK

1.92e-0460353PF07974
DomainNCD3G

GRM2 GRM3

2.63e-0413352PF07562
DomainGPCR_3_9-Cys_dom

GRM2 GRM3

2.63e-0413352IPR011500
DomainGPCR_3_CS

GRM2 GRM3

3.06e-0414352IPR017979
DomainEGF_CA

LRP2 FBN1 FBN2

5.55e-0486353PF07645
DomainGPCR_3

GRM2 GRM3

7.01e-0421352IPR000337
DomainG_PROTEIN_RECEP_F3_4

GRM2 GRM3

7.70e-0422352PS50259
Domain7tm_3

GRM2 GRM3

7.70e-0422352PF00003
DomainGPCR_3_C

GRM2 GRM3

7.70e-0422352IPR017978
DomainG_PROTEIN_RECEP_F3_2

GRM2 GRM3

7.70e-0422352PS00980
DomainG_PROTEIN_RECEP_F3_3

GRM2 GRM3

7.70e-0422352PS00981
DomainG_PROTEIN_RECEP_F3_1

GRM2 GRM3

7.70e-0422352PS00979
DomainASX_HYDROXYL

LRP2 FBN1 FBN2

8.61e-04100353PS00010
DomainEGF

LRP2 STAB2 SLIT3

1.68e-03126353PF00008
DomainANF_receptor

GRM2 GRM3

2.18e-0337352PF01094
DomainANF_lig-bd_rcpt

GRM2 GRM3

2.18e-0337352IPR001828
DomainPeripla_BP_I

GRM2 GRM3

2.42e-0339352IPR028082
PathwayWP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE

GRM2 GRM3

3.13e-0415252M39442
PathwayWP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE

GRM2 GRM3

3.13e-0415252MM15845
PathwayREACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC

MUC17 MUC5AC

3.57e-0416252M27410
PathwayREACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS

MUC17 MUC5AC

4.04e-0417252M27412
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC17 MUC5AC

6.21e-0421252MM15706
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC17 MUC5AC

7.47e-0423252M556
PathwayWP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE

FBN1 FBN2

8.83e-0425252M39713
PathwayREACTOME_DECTIN_2_FAMILY

MUC17 MUC5AC

9.56e-0426252M27483
Pubmed

Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.

FBN1 FBN2 VWF

8.52e-08936312122015
Pubmed

Characterization of a murine gene expressed from the inactive X chromosome.

GJB1 TAF1 AR

1.67e-07113632034278
Pubmed

The murine interleukin-2 receptor gamma chain gene: organization, chromosomal localization and expression in the adult thymus.

GJB1 TAF1 AR

2.89e-07133637805729
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

LRP2 FBN1 FBN2 MUC5AC

8.94e-077136433541421
Pubmed

Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.

FBN1 FBN2

1.04e-06236212399449
Pubmed

Selective silencing of individual dendritic branches by an mGlu2-activated potassium conductance in dentate gyrus granule cells.

GRM2 GRM3

1.04e-06236223616537
Pubmed

Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.

FBN1 FBN2

1.04e-06236221851253
Pubmed

Activation of metabotropic glutamate receptor type 2/3 supports the involvement of the hippocampal mossy fiber pathway on contextual fear memory consolidation.

GRM2 GRM3

1.04e-06236219638469
Pubmed

Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.

GRM2 GRM3

1.04e-06236221628565
Pubmed

Group II metabotropic glutamate receptor blockade promotes stress resilience in mice.

GRM2 GRM3

1.04e-06236230939596
Pubmed

Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.

FBN1 FBN2

1.04e-06236212429739
Pubmed

New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.

FBN1 FBN2

1.04e-06236230044367
Pubmed

Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.

FBN1 FBN2

1.04e-06236221440062
Pubmed

MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.

FBN1 FBN2

1.04e-06236215131124
Pubmed

Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice.

GRM2 GRM3

1.04e-06236224053122
Pubmed

Adaptive Changes in Group 2 Metabotropic Glutamate Receptors Underlie the Deficit in Recognition Memory Induced by Methamphetamine in Mice.

GRM2 GRM3

1.04e-06236238969501
Pubmed

Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction.

GRM2 GRM3

1.04e-06236225583490
Pubmed

Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.

FBN1 FBN2

1.04e-06236212524050
Pubmed

The mGluR2/3 agonist LY379268 induced anti-reinstatement effects in rats exhibiting addiction-like behavior.

GRM2 GRM3

1.04e-06236223624743
Pubmed

The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection.

GRM2 GRM3

1.04e-06236217670976
Pubmed

Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light.

GRM2 GRM3

1.04e-06236225950516
Pubmed

The effect of mGlu2/3 receptors on synaptic activities to different types of GABAergic interneurons in the anterior cingulate cortex.

GRM2 GRM3

1.04e-06236232525061
Pubmed

Microfibril structure masks fibrillin-2 in postnatal tissues.

FBN1 FBN2

1.04e-06236220404337
Pubmed

Association analysis of group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population.

GRM2 GRM3

1.04e-06236219386277
Pubmed

Expression and subcellular distribution of glutamate receptor subunits 2/3 in the developing cerebellar cortex.

GRM2 GRM3

1.04e-0623628838577
Pubmed

The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells.

GRM2 GRM3

1.04e-0623627965099
Pubmed

Metabotropic Glutamate Receptor 2/3 Activation Improves Motor Performance and Reduces Pathology in Heterozygous zQ175 Huntington Disease Mice.

GRM2 GRM3

1.04e-06236234330748
Pubmed

Fibrillln mutations in Marfan syndrome and related phenotypes.

FBN1 FBN2

1.04e-0623628791520
Pubmed

Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis.

GRM2 GRM3

1.04e-06236225434487
Pubmed

NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer's, and Ethanol Intoxication.

GRM2 GRM3

1.04e-06236228285415
Pubmed

Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: the metabotropic pathway.

GRM2 GRM3

1.04e-06236224080311
Pubmed

mGlu2/3 receptor in the prelimbic cortex is implicated in stress resilience and vulnerability in mice.

GRM2 GRM3

1.04e-06236234090896
Pubmed

Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.

FBN1 FBN2

1.04e-0623628120105
Pubmed

The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.

FBN1 FBN2

1.04e-06236235419902
Pubmed

Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.

FBN1 FBN2

1.04e-0623628307578
Pubmed

Fibrillin assembly: dimer formation mediated by amino-terminal sequences.

FBN1 FBN2

1.04e-06236210504303
Pubmed

Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.

FBN1 FBN2

1.04e-0623627744963
Pubmed

Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice.

GRM2 GRM3

1.04e-06236222089319
Pubmed

Fibrillin microfibrils in bone physiology.

FBN1 FBN2

1.04e-06236226408953
Pubmed

Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.

FBN1 FBN2

1.04e-06236218006876
Pubmed

Adaptor Protein ShcD/SHC4 Interacts with Tie2 Receptor to Synergistically Promote Glioma Cell Invasion.

SHC4 TEK

1.04e-06236233495401
Pubmed

Regulation of cocaine-induced reinstatement by group II metabotropic glutamate receptors in the ventral tegmental area.

GRM2 GRM3

1.04e-06236221881873
Pubmed

Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.

FBN1 FBN2

1.04e-06236224833718
Pubmed

Fractionation of spatial memory in GRM2/3 (mGlu2/mGlu3) double knockout mice reveals a role for group II metabotropic glutamate receptors at the interface between arousal and cognition.

GRM2 GRM3

1.04e-06236221832989
Pubmed

The role of group II metabotropic glutamate receptors in cognition and anxiety: comparative studies in GRM2(-/-), GRM3(-/-) and GRM2/3(-/-) knockout mice.

GRM2 GRM3

1.04e-06236225158312
Pubmed

Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.

FBN1 FBN2

1.04e-06236224265020
Pubmed

In vivo studies of mutant fibrillin-1 microfibrils.

FBN1 FBN2

1.04e-06236220529844
Pubmed

Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.

FBN1 FBN2

1.04e-06236225524144
Pubmed

Activation of Group II Metabotropic Glutamate Receptors Promotes LTP Induction at Schaffer Collateral-CA1 Pyramidal Cell Synapses by Priming NMDA Receptors.

GRM2 GRM3

1.04e-06236227911756
Pubmed

Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.

FBN1 FBN2

1.04e-06236223133647
Pubmed

Reduction of group II metabotropic glutamate receptors during development of benzodiazepine dependence.

GRM2 GRM3

1.04e-06236223392308
Pubmed

Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice.

GRM2 GRM3

1.04e-06236220970439
Pubmed

Fibrillins 1 and 2 perform partially overlapping functions during aortic development.

FBN1 FBN2

1.04e-06236216407178
Pubmed

Altered hippocampal expression of glutamate receptors and transporters in GRM2 and GRM3 knockout mice.

GRM2 GRM3

1.04e-06236218720515
Pubmed

Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice.

GRM2 GRM3

1.04e-06236234217776
Pubmed

Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.

FBN1 FBN2

1.04e-0623621852206
Pubmed

Metabotropic glutamate receptor 2/3 in the hippocampus of patients with mesial temporal lobe epilepsy, and of rats and mice after pilocarpine-induced status epilepticus.

GRM2 GRM3

1.04e-06236215246118
Pubmed

N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.

FBN1 FBN2

1.04e-06236210359653
Pubmed

Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia.

GRM2 GRM3

1.04e-06236218853337
Pubmed

Alveolar nonselective channels are ASIC1a/α-ENaC channels and contribute to AFC.

SCNN1A ASIC1

1.04e-06236228283476
Pubmed

Memantine-induced brain activation as a model for the rapid screening of potential novel antipsychotic compounds: exemplified by activity of an mGlu2/3 receptor agonist.

GRM2 GRM3

1.04e-06236221057775
Pubmed

Hippocampal mossy fiber long-term depression in Grm2/3 double knockout mice.

GRM2 GRM3

1.04e-06236221360593
Pubmed

Atomic force microscopy imaging reveals the formation of ASIC/ENaC cross-clade ion channels.

SCNN1A ASIC1

1.04e-06236226032502
Pubmed

Developmental expression of mGlu2 and mGlu3 in the mouse brain.

GRM2 GRM3

1.04e-06236227818290
Pubmed

Deficiency of Circulating Monocytes Ameliorates the Progression of Myxomatous Valve Degeneration in Marfan Syndrome.

CCR2 FBN1

3.12e-06336231928435
Pubmed

Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly.

FBN1 FBN2

3.12e-06336210825173
Pubmed

Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.

GRM2 GRM3

3.12e-06336234620856
Pubmed

Pharmacogenetic analysis of the mGlu2/3 agonist LY2140023 monohydrate in the treatment of schizophrenia.

GRM2 GRM3

3.12e-06336221173788
Pubmed

Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics.

GRM2 GRM3

3.12e-06336224949866
Pubmed

Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.

FBN1 FBN2

3.12e-06336230201140
Pubmed

The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity.

STAB2 VWF

3.12e-06336230124466
Pubmed

Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1 synapses.

GRM2 GRM3

3.12e-06336238864289
Pubmed

TAF1 differentially enhances androgen receptor transcriptional activity via its N-terminal kinase and ubiquitin-activating and -conjugating domains.

TAF1 AR

3.12e-06336220181722
Pubmed

Evaluation of 5-HT2A and mGlu2/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: effect of antidepressant treatment.

GRM2 GRM3

3.12e-06336225150943
Pubmed

Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation.

FBN1 FBN2

3.12e-06336220855508
Pubmed

mGlu2 and mGlu3 Negative Allosteric Modulators Divergently Enhance Thalamocortical Transmission and Exert Rapid Antidepressant-like Effects.

GRM2 GRM3

3.12e-06336231735403
Pubmed

Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migration.

SCNN1A ASIC1

3.12e-06336219561078
Pubmed

Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein.

FBN1 FBN2

6.24e-06436212429738
Pubmed

Group II metabotropic glutamate receptor interactions with NHERF scaffold proteins: Implications for receptor localization in brain.

GRM2 GRM3

6.24e-06436228392297
Pubmed

Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system.

GRM2 GRM3

6.24e-06436229079293
Pubmed

Inhibition of presynaptic calcium transients in cortical inputs to the dorsolateral striatum by metabotropic GABA(B) and mGlu2/3 receptors.

GRM2 GRM3

6.24e-06436225781000
Pubmed

Human eye development is characterized by coordinated expression of fibrillin isoforms.

FBN1 FBN2

6.24e-06436225406291
Pubmed

Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production.

FBN1 FBN2

6.24e-06436220729550
Pubmed

Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.

FBN1 FBN2

6.24e-06436225034023
Pubmed

MCP-1/CCR2B-dependent loop upregulates MUC5AC and MUC5B in human airway epithelium.

CCR2 MUC5AC

6.24e-06436221097527
Pubmed

Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes.

FBN1 FBN2

6.24e-06436216835936
Pubmed

Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice.

GRM2 GRM3

6.24e-06436215619115
Pubmed

tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.

VWF TEK

6.24e-0643621630810
Pubmed

Wnt Signaling Inhibition Prevents Postnatal Inflammation and Disease Progression in Mouse Congenital Myxomatous Valve Disease.

CCR2 FBN1

6.24e-06436238660802
Pubmed

Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: specific roles for mGlu2 in the amygdala and subcortical nuclei, and mGlu3 in the hippocampus.

GRM2 GRM3

6.24e-06436216733060
Pubmed

Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495.

GRM2 GRM3

6.24e-06436219477188
Pubmed

Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation.

FBN1 FBN2

1.04e-05536226601954
Pubmed

SCNN1, an epithelial cell sodium channel gene in the conserved linkage group on mouse chromosome 6 and human chromosome 12.

SCNN1A VWF

1.04e-0553627896277
Pubmed

Targeting the Hprt locus in mice reveals differential regulation of Tie2 gene expression in the endothelium.

VWF TEK

1.04e-05536211015584
Pubmed

Genomic organization and chromosomal localization of mouse Eplg2, a gene encoding a binding protein for the receptor tyrosine kinase elk.

GJB1 AR

1.04e-0553627896266
Pubmed

Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress.

GRM2 GRM3

1.04e-05536229024663
Pubmed

Relaxin regulates fibrillin 2, but not fibrillin 1, mRNA and protein expression by human dermal fibroblasts and murine fetal skin.

FBN1 FBN2

1.04e-05536212590922
Pubmed

Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.

FBN1 FBN2

1.04e-05536217255108
Pubmed

POGLUT2 and POGLUT3 O-glucosylate multiple EGF repeats in fibrillin-1, -2, and LTBP1 and promote secretion of fibrillin-1.

FBN1 FBN2

1.04e-05536234411563
Pubmed

Epithelial cells are the major site of hydroxysteroid (17beta) dehydrogenase 2 and androgen receptor expression in fetal mouse lungs during the period overlapping the surge of surfactant.

VWF AR

1.04e-05536219737616
InteractionSHC4 interactions

SHC4 TEK AR

7.88e-0622363int:SHC4
InteractionNTN5 interactions

LRP2 FBN1 FBN2

1.03e-0524363int:NTN5
Cytoband3p21.2

DOCK3 GRM2

1.01e-04193623p21.2
CytobandXq13.1

GJB1 TAF1

6.59e-0448362Xq13.1
CytobandEnsembl 112 genes in cytogenetic band chr3p21

DOCK3 CCR2 GRM2

1.95e-03316363chr3p21
GeneFamilyGlutamate metabotropic receptors|Protein phosphatase 1 regulatory subunits

GRM2 GRM3

5.11e-058252281
GeneFamilyCD molecules|Mucins

MUC17 MUC5AC

3.79e-0421252648
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF142 ZNF883 ZUP1 ZNF513

1.61e-0271825428
CoexpressionNABA_ECM_GLYCOPROTEINS

FBN1 FBN2 VWF CRIM1 OTOGL SLIT3

2.25e-07191366MM17059
CoexpressionNABA_CORE_MATRISOME

FBN1 FBN2 VWF CRIM1 OTOGL SLIT3

1.70e-06270366MM17057
CoexpressionNABA_MATRISOME

VWC2 FBN1 FBN2 VWF CRIM1 MUC17 MUC5AC OTOGL SLIT3

6.55e-061008369MM17056
CoexpressionNABA_ECM_GLYCOPROTEINS

FBN1 FBN2 VWF CRIM1 SLIT3

6.94e-06196365M3008
CoexpressionNABA_CORE_MATRISOME

FBN1 FBN2 VWF CRIM1 SLIT3

3.54e-05275365M5884
CoexpressionNABA_MATRISOME

VWC2 FBN1 FBN2 VWF CRIM1 MUC17 MUC5AC SLIT3

6.11e-051026368M5889
CoexpressionROETH_TERT_TARGETS_DN

CCR2 CRIM1

6.56e-059362M2891
CoexpressionGSE34156_UNTREATED_VS_24H_TLR1_TLR2_LIGAND_TREATED_MONOCYTE_UP

SCNN1A LRP2 CRIM1 MUC5AC

1.48e-04196364M8683
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_secretory-Secretory_Goblet|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SHC4 GJB1 FCGBP MUC5AC MKRN2OS

5.29e-071983655dd2aa7684c36beffa204ca4c04d0501cabac10f
ToppCellBronchial-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Mucous|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SCNN1A GJB1 FCGBP MUC5AC OTOGL

5.43e-07199365eb2d1b7e875c5bf833e7a80b43282e12893c34e9
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCR2 NCBP1 STAB2 AR

1.03e-0516936420fbf78382fb0ba9a63ab1aa0abc615476994ac5
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCNN1A GJB1 FCGBP MUC5AC

1.16e-05174364e7cca4b6a3935fad61cf2a3d9984ab1ffa1a9447
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCNN1A GJB1 FCGBP MUC5AC

1.16e-05174364ad5b56f0ace6455c033834b931ec870cc0dc9290
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK3 OTOGL UNC13A SLIT3

1.18e-05175364316f2ea930437bf1243b1c0f45e6bd864112c6f2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK3 OTOGL UNC13A SLIT3

1.18e-05175364a9f08e1e4c2997dcdd3e5d92daac480da19100b8
ToppCellwk_20-22-Endothelial-Blood_vessel_endothelial-OMD+_endo|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

FBN2 VWF CRIM1 TEK

1.21e-0517636452af8f717dbd3b59eeb868b8b7b256a8f3e57d7a
ToppCell356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FBN1 FCGBP MUC5AC AR

1.24e-05177364709235694cc711b9b79690e23c94577b2ae06811
ToppCell356C-Epithelial_cells-Epithelial-G_(Club-Clara_cells)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FBN1 FCGBP MUC5AC AR

1.24e-051773647f9c2a45a994b32f15e5693f7cb873716a4eb568
ToppCellfacs-Marrow-Granulocytes-3m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHC4 FBN1 AR SLIT3

1.26e-051783646d9ecfaeb50d562899380de379ebf7b99fd8adc9
ToppCellfacs-Marrow-Granulocytes-3m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHC4 FBN1 AR SLIT3

1.26e-05178364d3f518cd75b02e85d45cbb9b2eff30f0272512a8
ToppCell15-Trachea-Epithelial-Goblet-like_secretory|Trachea / Age, Tissue, Lineage and Cell class

SCNN1A GJB1 FCGBP MUC5AC

1.26e-05178364f0557920b9b3e7c4f39938d1b524aa58711af4d2
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-OMD+_endo|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FBN2 VWF CRIM1 TEK

1.29e-051793648c9ed247e1c4d655b81ce2f24a9936a7cade718a
ToppCelldroplet-Limb_Muscle-Pre-Sort|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 GJB1 VWF CRIM1

1.32e-05180364af2bafcd1b2082629de3ea336711add01565c4c4
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 GJB1 VWF CRIM1

1.32e-05180364f29a995cf6e1a1836ed68b73258d9370bf3d4434
ToppCellfacs-Pancreas-Exocrine-24m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 GJB1 FCGBP OTOGL

1.32e-0518036472310baeed848f2c483ae986cd73d2fb2cca7feb
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 STAB2 FBN2 OTOGL

1.44e-05184364ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 STAB2 FBN2 OTOGL

1.44e-051843642cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 STAB2 FBN2 OTOGL

1.44e-051843642b19a8c5f823e00812908b23e66bb4e563278aff
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 FBN1 FBN2 SLIT3

1.53e-051873644e553721fa5598cb211f44e3226280b7e6885484
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 FBN1 FBN2 SLIT3

1.53e-05187364d36e7fc6125e7a4310499365022d38f34b757a73
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 FBN1 FBN2 SLIT3

1.53e-05187364827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SCNN1A GJB1 FCGBP MUC5AC

1.57e-051883645901b276f2379abf486b8285957277e95f08464e
ToppCelldroplet-Pancreas-PANCREAS-30m-Endothelial-endothelial_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF CRIM1 TEK AR

1.63e-051903649d5242759546be0089981ef1877e4ed5f81face5
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWC2 FBN1 FBN2 SLIT3

1.63e-05190364947807863a9b247c301c6cf63d6fd5a2c8018e66
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SAXO2 ZSWIM2 FCGBP MUC5AC

1.63e-051903642fdc024d3d673a0134b74b4c5a63afe924995730
ToppCellPCW_05-06-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

SCNN1A DOCK3 LRP2 MUC5AC

1.67e-0519136405731ece7867659c662f952812805f947032fe10
ToppCelldroplet-Pancreas-PANCREAS-30m-Endothelial-endothelial_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF CRIM1 TEK AR

1.70e-05192364bcd8876235be503186f119653b39476488c0fa15
ToppCelldroplet-Pancreas-PANCREAS-30m-Endothelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF CRIM1 TEK AR

1.70e-05192364f4cd65e6c5b17bcabf45fe5b687246c72e7975f7
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

SCNN1A DOCK3 LRP2 MUC5AC

1.70e-05192364b99f8236ef4ccdc75c02abea381cae6453205f6f
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SCNN1A GJB1 FCGBP MUC5AC

1.84e-05196364c18874f37b90e6afacc562b2082b67ea8a7cb4a4
ToppCellBAL-Mild-Epithelial-Epithelial-Basal/Club-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SCNN1A GJB1 FCGBP MUC5AC

1.84e-0519636491a3c3091064f1f5a3bdc1dd5883fc24dce8ff05
ToppCellBAL-Mild-Epithelial-Epithelial-Basal/Club|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SCNN1A GJB1 FCGBP MUC5AC

1.84e-05196364e819088a74d29e958371aa851ac9c74ec55367b7
ToppCellBAL-Mild-Epithelial-Epithelial-Basal/Club|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

SCNN1A GJB1 FCGBP MUC5AC

1.84e-05196364e675d661b6494ac3a85ba7ee5bdeaa98b8bbe957
ToppCellBAL-Mild-Epithelial-Epithelial-Basal/Club-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SCNN1A GJB1 FCGBP MUC5AC

1.84e-05196364a4d05d85fbafa869df19bba3881020ea433d81fb
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-sinusoidal_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

STAB2 VWF CRIM1 TEK

1.88e-05197364f1080d93acf1a4756d2f2c8cabd1fb50bc7bcd09
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 VWF GRM2 TEK

1.88e-05197364ad4a3b5da2190be9495382a2952991e1de9f190d
ToppCellTracheal-10x5prime-Stromal-Peri/Epineurial_|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FBN1 FBN2 UNC13A SLIT3

1.88e-051973642cb1f557ce1400398975de94638126b4522567f3
ToppCellBronchial-10x5prime-Epithelial-Epi_submucosal-gland|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SCNN1A GJB1 FCGBP MUC5AC

1.88e-05197364e2c820c4e4a6cd01ceb020473286e3f5d4e3718e
ToppCellMild_COVID-19-Epithelial-Basal/Club|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

SCNN1A GJB1 FCGBP MUC5AC

1.88e-051973644cc5b778e1e2c6c149160fa147c172977c0fa8eb
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ADH5 FBN1 ZYX SLIT3

1.92e-051983640a4b19c3d5e65ecd24fc2ce80ac5276c813282c7
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ADH5 FBN1 ZYX SLIT3

1.96e-05199364e1849505b92820a219c5a2c35492bdd55579fb48
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

ADH5 FBN1 ZYX SLIT3

1.96e-05199364c2c42ecf20d1924edc2f899c01dfa5fcf3c210b9
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

ADH5 FBN1 ZYX SLIT3

2.00e-05200364ab4fda0cc95cb8f80ea9f28745013f3248def820
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ADH5 FBN1 ZYX SLIT3

2.00e-0520036444a68bacdb3d5bf563bd35952176995850933a81
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ADH5 FBN1 ZYX SLIT3

2.00e-05200364b79628fd1386aa9a3b0e9fa81def0bc100c3c073
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ADH5 FBN1 ZYX SLIT3

2.00e-0520036450ca6550998e461ef26dd670351060bd940765a8
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ADH5 FBN1 ZYX SLIT3

2.00e-05200364dc61016c61729f69649cfb21f6264e685ce83dea
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_airway_secretory-Secretory_Goblet|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SCNN1A GJB1 FCGBP MUC5AC

2.00e-05200364133853d0f55c63ebe94dd54151f9f1f90650a0d8
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_airway_secretory|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SCNN1A GJB1 FCGBP MUC5AC

2.00e-052003648f811ddd84c037a250d124496b0fbb2e4717011c
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ADH5 FBN1 ZYX SLIT3

2.00e-052003643bdba9612cd7c612b76aa9abecc4a6529aabfc1c
ToppCellStriatum-Macroglia-CSF_related-EPENDYMAL-Ependyma_Ccdc153.Ccdc153_(Ccdc153)-|Striatum / BrainAtlas - Mouse McCarroll V32

LRP2 ZSWIM2 MKRN2OS

1.15e-0411736326dec09112532f351fb7a2202bae84c365707b40
ToppCellStriatum-Macroglia-CSF_related-EPENDYMAL-Ependyma_Ccdc153.Ccdc153_(Ccdc153)|Striatum / BrainAtlas - Mouse McCarroll V32

LRP2 ZSWIM2 MKRN2OS

1.15e-04117363db053c874e6739052dff1f91643e51b306236237
ToppCellStriatum-Macroglia-CSF_related-EPENDYMAL-Ependyma_Ccdc153.Ccdc153_(Ccdc153)--|Striatum / BrainAtlas - Mouse McCarroll V32

LRP2 ZSWIM2 MKRN2OS

1.15e-0411736380780223502d18f0d86a29ff3cb74aa8235103c7
ToppCellStriatum-Macroglia-CSF_related-EPENDYMAL|Striatum / BrainAtlas - Mouse McCarroll V32

LRP2 ZSWIM2 MKRN2OS

1.15e-0411736340889f4a387846abbf54469cc4faf616bfe348d0
ToppCellStriatum-Macroglia-CSF_related|Striatum / BrainAtlas - Mouse McCarroll V32

LRP2 ZSWIM2 MKRN2OS

1.15e-04117363e12e37e393257db85f7f5c13454095c44f59d374
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN2 VWF TEK

1.21e-04119363c3f1223356e7f245a460ea5568a223e34e458dc1
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Intermediate|GW19 / Sample Type, Dataset, Time_group, and Cell type.

AR ZUP1 SLIT3

1.24e-04120363eb5b88c47dd4a6f9b55ace24f19d4e81d4ed31e1
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SHC4 FCGBP MKRN2OS

1.75e-04135363c1752595de485075d71127411da33aaa191c426b
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCR2 STAB2 AR

1.99e-04141363d3ce2218bfa9750795d920e1ef162ea44efb2e66
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCR2 STAB2 AR

2.12e-0414436346177f0d6117e701bda86a99ac2a1b0e7ed66177
ToppCell10x3'2.3-week_12-13-Myeloid_DC-DC-tDC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

CCR2 SHC4 GRM3

2.17e-04145363a6c291811bf62f1c13f1b4b396d75c2223cf1c7d
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SHC4 FCGBP MKRN2OS

2.21e-04146363d33bd571c2adf5f89e6f02e77d094c19edd4729c
ToppCell10x5'-bone_marrow-Myeloid_Monocytic-Cycling_mono|bone_marrow / Manually curated celltypes from each tissue

CCR2 ZSWIM2 FBN2

2.30e-04148363de35eeefad0e27a0d127e2e4bedead2bddb75152
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Fam159b|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

VWC2 FBN2 ASIC1

2.30e-041483639205b26e0d042b342cc643cda0f4f3f8bb392d00
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

STAB2 VWF TEK

2.39e-041503634f31867cb85253ff6d22f3b02ef972a42cb41123
ToppCellfacs-Brain_Myeloid-Cortex-3m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCNN1A LRP2 CCR2

2.54e-041533630ef7c45cdd854c79e527006034029767f8e108b2
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GJB1 FCGBP MUC5AC

2.63e-0415536362b59cb32b12bd55b19e98786a866d788fc9e4bf
ToppCellfacs-Liver-Non-hepatocytes-3m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 FBN2 TEK

2.63e-041553638fdda4e3657ac56188ae88ed3caf145f4d9d1567
ToppCellPND07-28-samps-Mesenchymal-Mesothelial-Mesothelial|PND07-28-samps / Age Group, Lineage, Cell class and subclass

LRP2 ASIC1 AR

2.68e-04156363605d95a900e1443d3f6aae163ef2e893d3293203
ToppCellPND07-28-samps-Mesenchymal-Mesothelial|PND07-28-samps / Age Group, Lineage, Cell class and subclass

LRP2 ASIC1 AR

2.68e-04156363574f761962a7dd3308bd41fc529dd3ea1b8625f8
ToppCellChildren_(3_yrs)-Mesenchymal-chondrocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

VWC2 FBN1 SLIT3

2.73e-04157363f147e24f2ece82e1c54750868954d09b3c461804
ToppCellfacs-Spleen-nan-18m-Lymphocytic-NK_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCR2 SHC4 ZYX

2.73e-04157363a84377028c661f8f3ecae0f6082abdd859faf0c8
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCR2 STAB2 AR

2.84e-041593635c7a099aa84ecc62bf9b5e1609e5b6b77889f175
ToppCellfacs-Heart-LA-24m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF ZYX SLIT3

2.94e-04161363248487415a0601d57ef2a6692e22a61368d0b9c8
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DOCK3 SHC4 SLIT3

2.94e-041613635fba13f0aa5002f7eefe219e2c6a07e163f1a50d
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCR2 STAB2 AR

3.05e-04163363476e94e1d132eaaecb9e376bd32748a75ad22081
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_arterial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

VWC2 VWF TEK

3.11e-041643633cd80e6275f0f9b5667912139d15ebf5e6b17f2f
ToppCell343B-Epithelial_cells-Epithelial-A_(AT2)-|343B / Donor, Lineage, Cell class and subclass (all cells)

SCNN1A LRP2 OTOGL

3.11e-04164363beaa13a75c3bb72446c85084d75e9fe3f15fd3d4
ToppCell343B-Epithelial_cells-Epithelial-A_(AT2)|343B / Donor, Lineage, Cell class and subclass (all cells)

SCNN1A LRP2 OTOGL

3.11e-04164363d005cfd821b87548b075120bffe65a0be9860463
ToppCellPND14-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCNN1A FCGBP MUC5AC

3.16e-04165363baff639a7046fb5cacb70f341b6d24cef3519f8e
ToppCellPND14-Epithelial-Epithelial_Airway-Neurosecretory|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCNN1A FCGBP MUC5AC

3.16e-041653636fdce8b23736409a23884ef3918638ffc067a86f
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 MUC5AC MKRN2OS

3.16e-04165363f80665b75d43f1bf6919d59fc762e7e0bac653f2
ToppCellPND14-Epithelial-Epithelial_Airway-Neurosecretory-Secretory|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCNN1A FCGBP MUC5AC

3.16e-04165363dd4d36ff8efb89fee1fb4c48d1b8f46902119909
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF CRIM1 TEK

3.22e-041663637a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

VWF CRIM1 TEK

3.22e-04166363f7926ee266dcbf10df375cd921f1db5a2fa604f8
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWF CRIM1 TEK

3.22e-04166363bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCellfacs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l15|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SHC4 FBN2 ASIC1

3.28e-0416736355c3c68af269fcf40f2b080ae4489523609ad388
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GJB1 FCGBP MUC5AC

3.28e-0416736331633899aae852873a4887e72c621474b0a51a33
ToppCellAdult-Epithelial-lung_goblet_cell-D122|Adult / Lineage, Cell type, age group and donor

FCGBP MUC5AC AR

3.28e-041673636efbb2ef6adc8da5dd67210969f825f5cc8ed022
ToppCellfacs-Aorta-Heart-3m-Endothelial-endocardial_endothelial_cells|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 VWF OTOGL

3.28e-04167363a4a795751644b22af616335379e64ae95175180c
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FBN2 VWF TEK

3.28e-04167363774f3264318b002d0df5d06d41d645366038d0bf
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

VWF CRIM1 TEK

3.28e-04167363d7fe24cdc4b55a9555ce9e20699f5036b88148e9
ToppCellfacs-GAT-Fat-18m-Epithelial|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GJB1 FCGBP MKRN2OS

3.34e-04168363d6c8056b7d6b937bb91e6b33beeb1075dce1685c
ToppCellfacs-GAT-Fat-18m-Epithelial-epithelial_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GJB1 FCGBP MKRN2OS

3.34e-041683637102c52bf1b2ba67bb3700932181a2e0a6627711
ToppCellfacs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWF CRIM1 TEK

3.34e-0416836306dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCR2 STAB2 UNC13A

3.34e-04168363a7eb28e15b591997f1aee09501cb20ae18beca08
ToppCellfacs-GAT-Fat-18m-Epithelial-nan|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GJB1 FCGBP MKRN2OS

3.34e-0416836368a2f9fd53b54023241acd1620cf24226f639c1b
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D122|Adult / Lineage, Cell type, age group and donor

VWC2 VWF TEK

3.34e-041683638c3e1e45b422813bcdfa4273b1167db649a312f5
ComputationalPorins / transporters.

SCNN1A LRP2 GJB1 TEK ASIC1 AR

4.07e-06211236MODULE_63
ComputationalHeart, liver, kidney and pancreas metabolic and xenobiotic response genes.

SCNN1A GJB1 FBN2 FCGBP VWF CRIM1 GRM2 ZYX AR

2.98e-05835239MODULE_88
ComputationalGenes in the cancer module 27.

LRP2 CCR2 GRM2 GRM3 TEK AR

7.80e-05355236MODULE_27
ComputationalAdhesion molecules.

FBN1 FBN2 VWF ZYX

2.07e-04141234MODULE_122
ComputationalSecreted signaling molecules.

GJB1 TEK ZYX AR

2.56e-04149234MODULE_92
ComputationalPlacenta genes.

GJB1 FBN2 FCGBP VWF CRIM1 ZYX

3.34e-04463236MODULE_38
ComputationalDevelopmental processes.

GJB1 FBN1 TEK AR SLIT3

5.88e-04333235MODULE_220
ComputationalGPCR signaling pathways (immune and neuro).

CCR2 GRM2 GRM3

8.90e-0490233MODULE_375
ComputationalOvary genes.

FBN1 VWF CRIM1 ZYX AR

9.25e-04368235MODULE_1
ComputationalGenes in the cancer module 128.

CCR2 GJB1 VWF

1.11e-0397233MODULE_128
ComputationalGenes in the cancer module 79.

CCR2 GJB1 VWF

1.17e-0399233MODULE_79
ComputationalImmune response.

CCR2 GJB1 VWF

1.21e-03100233MODULE_170
ComputationalGenes in the cancer module 55.

SCNN1A GJB1 FBN2 CRIM1 GRM2 ZYX AR

1.32e-03832237MODULE_55
ComputationalTrachea genes.

SCNN1A FCGBP VWF CRIM1 ZYX

1.58e-03415235MODULE_6
ComputationalLung genes.

SCNN1A VWF CRIM1 TEK ZYX

1.93e-03434235MODULE_5
ComputationalGenes in the cancer module 289.

CCR2 GRM2 GRM3

2.24e-03124233MODULE_289
ComputationalMetal / Ca ion binding.

FBN1 FBN2 SLIT3

2.74e-03133233MODULE_324
ComputationalNeighborhood of TIMP2

FBN2 CRIM1

4.28e-0346232GNF2_TIMP2
ComputationalNeighborhood of KISS1

FBN2 CRIM1

4.85e-0349232GNF2_KISS1
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

VWF TEK

5.04e-0350232GAVISH_3CA_METAPROGRAM_ENDOTHELIAL_HEV_2
DrugAC1NSKBB

TAF1 GRM2 GRM3

1.03e-0613363CID005311256
DrugT2755

SCNN1A GRM2 GRM3 ASIC1

4.74e-0671364CID000005514
Drug2-amino-3-phosphonopropionic acid

ADH5 TAF1 GRM2 GRM3

6.23e-0676364CID000003857
DrugLY 379268

GRM2 GRM3

7.28e-063362ctd:C118218
Drugisospaglumic acid

GRM2 GRM3

7.28e-063362ctd:C027172
DrugAC1L1D63

TAF1 GRM2 GRM3

8.15e-0625363CID000002209
DrugPbTx-1

SCNN1A GJB1 ASIC1

1.03e-0527363CID006437089
DrugMolsidomine [25717-80-0]; Up 200; 16.6uM; MCF7; HT_HG-U133A

FBN1 STAB2 GRM3 ASIC1 MUC5AC

1.36e-051963652862_UP
DrugLY 341495

GRM2 GRM3

1.46e-054362ctd:C114624
DrugNPC 12626

GRM2 GRM3 AR

1.58e-0531363CID000108099
Drugrosavin

FBN1 FBN2 AR

1.74e-0532363ctd:C529148
DrugAcamprosate

GRM2 GRM3

2.42e-055362DB00659
Drug4CPG

TAF1 GRM2 GRM3

2.95e-0538363CID000005115
Drugazetidine-2,4-dicarboxylic acid

GRM2 GRM3

5.08e-057362CID000005370
Drugketamine

SCNN1A VWF GRM2 GRM3 ASIC1

5.47e-05262365CID000003821
Drugfuniferine N-oxide

FBN1 FBN2 AR

6.36e-0549363CID000191631
Drugmethylenecyclopropylglycine

TAF1 GRM2 GRM3

6.36e-0549363CID000441452
DrugL-CCG-I

TAF1 GRM2 GRM3

6.76e-0550363CID000001271
Drug5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione

TAF1 AR

6.77e-058362ctd:C513003
Drugcis-MCG-I

GRM2 GRM3

6.77e-058362CID003035584
DrugLY354740

TAF1 GRM2 GRM3

7.18e-0551363CID000114827
DrugAmiloride

SCNN1A ASIC1

8.69e-059362DB00594
Drugnitazoxanide

AR SLIT3

8.69e-059362ctd:C041747
DrugAC1N21PP

GRM2 GRM3

8.69e-059362CID004014619
Drug1,3-cyclopentanedicarboxylic acid

GRM2 GRM3

8.69e-059362CID000107216
DrugmM PEP

GRM2 GRM3

8.69e-059362CID005311462
Drug2-phenylglycine

TAF1 GRM2 GRM3

9.00e-0555363CID000003866
DrugAnidulafungin

GJB1 GRM2 GRM3 AR

1.08e-04157364CID000166548
DrugNS-105

GRM2 GRM3

1.09e-0410362CID000198695
DrugAC-474

DOCK3 VWF AR

1.11e-0459363CID000002999
DrugPropolis

FBN1 FBN2 AR

1.17e-0460363ctd:D011429
Drug3,5-dihydroxyphenylglycine

TAF1 GRM2 GRM3

1.17e-0460363CID000108001
Drugcyclobutylene AP5

GRM2 GRM3

1.32e-0411362CID000126582
Drug3-chlorophenol

CCR2 AR

1.32e-0411362ctd:C030682
Druggabapentin

SCNN1A GRM2 GRM3 ASIC1

1.43e-04169364CID000003446
Drugmexiletine

SCNN1A ZSWIM2 ASIC1

1.55e-0466363CID000004178
DrugAtpa

GRM2 GRM3

1.59e-0412362CID000002252
DrugPiperidines

CCR2 GRM2

1.59e-0412362ctd:D010880
Drugriluzole

SCNN1A GRM2 GRM3 ASIC1

1.60e-04174364CID000005070
DrugDCG-IV

TAF1 GRM2 GRM3

1.70e-0468363CID000115114
Drugprochlorperazine dimaleate salt; Up 200; 10uM; MCF7; HT_HG-U133A

ASIC1 MUC5AC ZYX AR

1.79e-041793641640_UP
Drugstrychnine HCl

SCNN1A GRM2 GRM3 ASIC1

1.87e-04181364CID000005304
Drugbicyclo[3.1.0]hexane

GRM2 GRM3

1.88e-0413362CID000067510
DrugMspg

GRM2 GRM3

1.88e-0413362CID003964410
DrugMSOPPE

GRM2 GRM3

1.88e-0413362CID005311463
DrugAC1L1E5T

FBN2 GRM2 GRM3

2.18e-0474363CID000002653
Drug2-methyl-6-styrylpyridine

GRM2 GRM3

2.19e-0414362CID000235382
DrugMTPG

GRM2 GRM3

2.19e-0414362CID005311456
DrugPF-00875133-00 [351322-64-0]; Up 200; 10uM; MCF7; HT_HG-U133A

DOCK3 ASIC1 MUC5AC ZYX

2.43e-041943645923_UP
Drug3,2'-dimethyl-4-aminobiphenyl

GJB1 AR

2.52e-0415362CID000025948
DrugPargyline hydrochloride [306-07-0]; Up 200; 20.4uM; HL60; HG-U133A

ZNF142 STAB2 FBN2 SLIT3

2.53e-041963641418_UP
Drug3-nitropropionic acid; Down 200; 10uM; MCF7; HT_HG-U133A

FBN1 GRM2 ASIC1 MUC5AC

2.53e-041963646402_DN
DrugEpicatechin-(-) [154-23-4]; Up 200; 13.8uM; MCF7; HT_HG-U133A

DOCK3 STAB2 ASIC1 MUC5AC

2.53e-041963644419_UP
DrugVitamin K2 [11032-49-8]; Up 200; 9uM; PC3; HT_HG-U133A

LRP2 GRM2 MUC5AC UNC13A

2.58e-041973643798_UP
DrugHemicholinium bromide [312-45-8]; Down 200; 7uM; MCF7; HT_HG-U133A

LRP2 STAB2 GTDC1 ASIC1

2.58e-041973643216_DN
DrugPirenzepine dihydrochloride [29868-97-1]; Up 200; 9.4uM; MCF7; HT_HG-U133A

NCBP1 GRM3 TEK ASIC1

2.63e-041983642234_UP
DrugTolfenamic acid [13710-19-5]; Up 200; 15.2uM; PC3; HT_HG-U133A

LRP2 FBN1 STAB2 ASIC1

2.63e-041983646354_UP
DrugAzacyclonol [115-46-8]; Up 200; 15uM; HL60; HG-U133A

SCNN1A GJB1 STAB2 SLIT3

2.63e-041983642020_UP
DrugMepenzolate bromide [76-90-4]; Up 200; 9.6uM; PC3; HT_HG-U133A

LRP2 GRM2 GRM3 SLIT3

2.63e-041983643748_UP
DrugMafenide hydrochloride [138-37-4]; Up 200; 18uM; PC3; HT_HG-U133A

SCNN1A LRP2 ASIC1 MUC5AC

2.68e-041993645079_UP
DrugClindamycin hydrochloride [21462-39-5]; Up 200; 8.6uM; HL60; HG-U133A

SCNN1A GJB1 STAB2 SLIT3

2.68e-041993641373_UP
Drug(S)-(-)-Atenolol [93379-54-5]; Up 200; 15uM; MCF7; HT_HG-U133A

SCNN1A LRP2 TAF1 STAB2

2.68e-041993646444_UP
Drugvaldecoxib; Down 200; 10uM; MCF7; HT_HG-U133A

FBN1 GRM2 ASIC1 MUC5AC

2.68e-041993646403_DN
DrugParoxetine maleate [64006-44-6]; Down 200; 1uM; MCF7; HT_HG-U133A

NCBP1 STAB2 CRIM1 GTDC1

2.73e-042003643904_DN
DrugN-phenylanthranilic acid; Down 200; 10uM; MCF7; HG-U133A

FBN2 CRIM1 GRM2 TEK

2.73e-04200364317_DN
DrugGBR 12909 dihydrochloride [67469-78-7]; Down 200; 7.6uM; MCF7; HT_HG-U133A

LRP2 NCBP1 STAB2 CRIM1

2.73e-042003643240_DN
Drugethylglutamate

GRM2 GRM3

2.88e-0416362CID000014241
Drug2-PMPA

GRM2 GRM3

2.88e-0416362CID010130754
Drugethanol

ADH5 SCNN1A ZNF142 VWF GRM3 ASIC1 MUC5AC

2.91e-04837367CID000000702
DrugOvalbumin

LRP2 FBN1 MUC5AC

2.95e-0482363ctd:D010047
Drug3HPG

GRM2 GRM3

3.26e-0417362CID000001217
DrugO,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate

CRIM1 GRM2 UNC13A SLIT3

3.35e-04211364ctd:C009618
DrugAC1NB8R3

TAF1 GRM2 GRM3 ZYX

3.47e-04213364CID004489307
Drugxenon

VWF GRM3 AR

3.63e-0488363CID000023991
DrugS-acetyl

GRM2 GRM3

3.66e-0418362CID000137849
Drugmoricizine

SCNN1A ZSWIM2

3.66e-0418362CID000034632
Drugacromelic acid A

GRM2 GRM3

3.66e-0418362CID000108086
Drugaurintricarboxylic acid

VWF GRM2 GRM3

4.01e-0491363CID000002259
Drug2-amino-4-phosphonobutyric acid

TAF1 GRM2 GRM3

4.01e-0491363CID000002207
Drugaminocyclopentane

GRM2 GRM3

4.09e-0419362CID000002906
DrugLY382884

GRM2 GRM3

4.09e-0419362CID000656723
Drugdiprafenone

SCNN1A ASIC1

4.09e-0419362CID000071249
Drug4-carboxy-3-hydroxyphenylglycine

GRM2 GRM3

4.54e-0420362CID000001297
DrugP-31

TAF1 VWF

4.54e-0420362CID000017959
DrugAC1L1GHE

TAF1 FBN2 AR

4.69e-0496363CID000003684
Drugpuerarin

FBN1 FBN2 AR

4.98e-0498363ctd:C033607
DrugAC1NBUB1

GRM2 GRM3

5.01e-0421362CID004473866
DrugCX546

GRM2 GRM3

5.01e-0421362CID000002890
Drugicilin

GRM2 ASIC1

5.01e-0421362CID000161930
Drug3,4-dihydroxyphenylglycine

GRM2 GRM3

5.01e-0421362CID000027915
DrugTAAD

FBN1 FBN2

5.01e-0421362CID000133445
Drugnitrofen

SCNN1A FBN1 AR SLIT3

5.19e-04237364ctd:C007350
DrugTritolyl Phosphates

GJB1 AR

5.50e-0422362ctd:D014317
DrugN-palmitoyl-l-methionine

GRM2 GRM3

5.50e-0422362CID000486207
DrugChlorogenic Acid

FBN1 FBN2 AR

5.76e-04103363ctd:D002726
DrugMSOP

GRM2 GRM3

6.02e-0423362CID003964633
DrugYM90K

GRM2 GRM3

6.02e-0423362CID005486547
Drugracemethorphan

SCNN1A GRM2 GRM3

6.44e-04107363CID000003008
Drug2-chloro-N6-cyclopentyladenosine

GRM2 GRM3

6.56e-0424362CID000001547
DrugCGP 39653

GRM2 GRM3

6.56e-0424362CID006437837
DiseaseEpilepsy, Benign Psychomotor, Childhood

GRM2 GRM3 TEK

2.66e-0623353C0393672
DiseaseEpilepsy, Lateral Temporal

GRM2 GRM3 TEK

2.66e-0623353C0393682
DiseaseUncinate Epilepsy

GRM2 GRM3 TEK

2.66e-0623353C0014558
DiseaseEpilepsy, Temporal Lobe

GRM2 GRM3 TEK

2.66e-0623353C0014556
DiseaseAddicted to cocaine

GRM2 GRM3

4.10e-063352C0858355
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN2

4.10e-063352DOID:65 (implicated_via_orthology)
Diseasescoliosis (is_implicated_in)

FBN1 FBN2

8.19e-064352DOID:0060249 (is_implicated_in)
DiseaseAlcoholic Intoxication, Chronic

ADH5 VWF GRM2 GRM3 AR

1.55e-05268355C0001973
Diseasemesangial proliferative glomerulonephritis (biomarker_via_orthology)

FBN1 VWF

3.81e-058352DOID:4783 (biomarker_via_orthology)
DiseaseMetabolic Bone Disorder

ANKRD11 LRP2

1.23e-0414352C0005944
Diseaserespiratory quotient

VWC2 UNC13A

1.23e-0414352EFO_0005189
DiseaseProteinuria

LRP2 VWF

1.42e-0415352HP_0000093
DiseaseOsteopenia

ANKRD11 LRP2

1.42e-0415352C0029453
Diseasefactor VIII measurement, Ischemic stroke

STAB2 VWF

2.31e-0419352EFO_0004630, HP_0002140
Diseaseattention deficit hyperactivity disorder (is_implicated_in)

DOCK3 AR

2.56e-0420352DOID:1094 (is_implicated_in)
Diseasesexual dimorphism measurement

ANKRD11 DOCK3 ZNF142 FBN1 CRIM1 ASIC1 SLIT3

2.73e-041106357EFO_0021796
Diseasegastric ulcer (biomarker_via_orthology)

TEK MUC5AC

2.83e-0421352DOID:10808 (biomarker_via_orthology)
Diseasefactor VIII measurement, von Willebrand factor measurement

STAB2 VWF

4.71e-0427352EFO_0004629, EFO_0004630
Diseasemacrophage inflammatory protein 1b measurement

DOCK3 CCR2 GRM2

5.63e-04136353EFO_0008219
DiseaseIschemic stroke, von Willebrand factor measurement

STAB2 VWF

5.82e-0430352EFO_0004629, HP_0002140
Diseasefactor VIII measurement, venous thromboembolism

STAB2 VWF

7.49e-0434352EFO_0004286, EFO_0004630
DiseaseCOVID-19 symptoms measurement

CCR2 MUC5AC

7.94e-0435352EFO_0600019
Diseasebody surface area

ANKRD11 FBN1 FBN2 CRIM1 SLIT3

9.14e-04643355EFO_0022196
Diseasevenous thromboembolism, factor VII measurement

ADH5 VWF

9.35e-0438352EFO_0004286, EFO_0004619
Diseasethioredoxin domain-containing protein 12 measurement

DOCK3 GRM2

9.85e-0439352EFO_0008298
Diseasefactor VIII measurement

STAB2 VWF

1.04e-0340352EFO_0004630
DiseaseDiaphragmatic Hernia

LRP2 SLIT3

1.09e-0341352C0019284
Diseasevenous thromboembolism, von Willebrand factor measurement

STAB2 VWF

1.14e-0342352EFO_0004286, EFO_0004629
Diseaseamino acid measurement

LRP2 VWC2 VWF GTDC1 SLIT3

1.16e-03678355EFO_0005134

Protein segments in the cluster

PeptideGeneStartEntry
GPECYELQVCVKDYC

UNC13A

1611

Q9UPW8
CCITPQAPQCYAEYV

ANKRD11

2456

Q6UB99
PLYIPQCGECKFCLN

ADH5

91

P11766
EVCCWLCIPCQPYEY

GRM2

516

Q14416
VCCWICIPCEPYEYL

GRM3

526

Q14832
LCPANPTCIYKYGDE

NCBP1

476

Q09161
FPCKNGRCVPNYYLC

LRP2

1031

P98164
PPICYNYEIRIQCCE

MUC5AC

2031

P98088
DYYFPPQKTCLICGD

AR

551

P10275
LYLGLPCCKEDYNGC

DOCK3

561

Q8IZD9
AYCPAYVVKSVPGCE

FCGBP

341

Q9Y6R7
SPEACYECKINGYPK

FBN1

2711

P35555
CERYYVPEGECCPVC

CRIM1

376

Q9NZV1
CQKEDSVYVCGPYFP

CCR2

181

P41597
VKCDVYPCPNTVDCF

GJB1

166

P08034
CICPPGYEVKSENCI

FBN2

2041

P35556
AMLEAVYCGCYPLCP

GTDC1

376

Q4AE62
VYCGCYPLCPKDLVY

GTDC1

381

Q4AE62
IKECGCAYIFYPRPQ

SCNN1A

426

P37088
YCSLSCPEGKEYQPC

OTOGL

1801

Q3ZCN5
LKCQCPNLYYGELCE

MUC17

4156

Q685J3
DPGAPDCKYGETVYC

TAF1

711

P21675
YCTPEQYKECADPAL

ASIC1

336

P78348
MAYCPIQCEKLCYLP

SHC4

401

Q6S5L8
CTQDPVELYRCACPY

SLIT3

931

O75094
YKCPLCPYACGNLAN

ZNF513

416

Q8N8E2
DPVYEPDQCCPICKN

VWC2

261

Q2TAL6
CVPKAQCPCYYDGEI

VWF

701

P04275
CEKYIYSFSVPQCCP

MKRN2OS

16

H3BPM6
CECYSAYTGPKCDKP

STAB2

181

Q8WWQ8
QEGCKSYVFCLPDPY

TEK

271

Q02763
SCGSDYCPYEIVKQP

SAXO2

16

Q658L1
PIEGKCYKCTECIEY

ZSWIM2

241

Q8NEG5
PLYDCPMCGLICTNY

ZUP1

191

Q96AP4
PYCEGCYTDTLEKCN

ZYX

431

Q15942
NPYLCTECGKGYTCL

ZNF883

11

P0CG24
TGLKPYQCPECEYCT

ZNF142

1531

P52746