Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	3.87e-06	5	147	3	GO:0030156
GeneOntologyMolecularFunction	DNA insertion or deletion binding	MSH3 MSH6 PCNA	7.69e-06	6	147	3	GO:0032135
GeneOntologyMolecularFunction	hepoxilin-epoxide hydrolase activity	ALOX12 ALOX15	5.38e-05	2	147	2	GO:0047977
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	RIN3 EPS8L2 PLEKHG4 DOCK11 DOCK9 PLEKHG5 DENND3 RGL1 PREX1	5.48e-05	231	147	9	GO:0005085
GeneOntologyMolecularFunction	mismatched DNA binding	MSH3 MSH6 PCNA	1.34e-04	14	147	3	GO:0030983
GeneOntologyMolecularFunction	linoleate 13S-lipoxygenase activity	ALOX12 ALOX15	1.61e-04	3	147	2	GO:0016165
GeneOntologyMolecularFunction	arachidonate 15-lipoxygenase activity	ALOX12 ALOX15	1.61e-04	3	147	2	GO:0050473
GeneOntologyMolecularFunction	single guanine insertion binding	MSH3 MSH6	1.61e-04	3	147	2	GO:0032142
GeneOntologyMolecularFunction	dinucleotide insertion or deletion binding	MSH3 PCNA	1.61e-04	3	147	2	GO:0032139
GeneOntologyMolecularFunction	arachidonate 12(S)-lipoxygenase activity	ALOX12 ALOX15	3.20e-04	4	147	2	GO:0004052
GeneOntologyMolecularFunction	guanine/thymine mispair binding	MSH3 MSH6	3.20e-04	4	147	2	GO:0032137
GeneOntologyMolecularFunction	single base insertion or deletion binding	MSH3 MSH6	3.20e-04	4	147	2	GO:0032138
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	RIN3 EPS8L2 TBC1D30 PLEKHG4 DOCK11 DOCK9 PLEKHG5 DENND3 RGL1 AGFG1 DEPDC5 PREX1	3.80e-04	507	147	12	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	RIN3 EPS8L2 TBC1D30 PLEKHG4 DOCK11 DOCK9 PLEKHG5 DENND3 RGL1 AGFG1 DEPDC5 PREX1	3.80e-04	507	147	12	GO:0030695
GeneOntologyMolecularFunction	DNA damage sensor activity	MSH3 SIRT6 MSH6	7.06e-04	24	147	3	GO:0140612
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	WAPL POLA1 MSH3 XRCC4 MSH6 ERCC6L2 TOP3A PCNA	7.33e-04	262	147	8	GO:0140097
GeneOntologyMolecularFunction	MutLalpha complex binding	MSH6 PCNA	1.10e-03	7	147	2	GO:0032405
GeneOntologyMolecularFunction	microtubule motor activity	DNHD1 KIF7 DNAH17 KIFC1	1.77e-03	70	147	4	GO:0003777
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNHD1 KIF7 DNAH17 MYO15A KIFC1	1.81e-03	118	147	5	GO:0003774
GeneOntologyCellularComponent	stereocilium	EPS8L2 LOXHD1 STRC MYO15A STRCP1	1.26e-04	69	147	5	GO:0032420
GeneOntologyCellularComponent	stereocilium bundle	EPS8L2 LOXHD1 STRC MYO15A STRCP1	2.38e-04	79	147	5	GO:0032421
GeneOntologyCellularComponent	stereocilium tip	EPS8L2 STRC STRCP1	4.76e-04	22	147	3	GO:0032426
GeneOntologyCellularComponent	GATOR1 complex	SZT2 DEPDC5	4.84e-04	5	147	2	GO:1990130
MousePheno	ectopic manchette	RIMBP3 AGFG1 RIMBP3C RIMBP3B	1.64e-05	19	117	4	MP:0009377
MousePheno	abnormal sperm nucleus morphology	RIMBP3 GMCL2 CEP72 AGFG1 RIMBP3C RIMBP3B	3.52e-05	74	117	6	MP:0009232
Domain	DNA_mismatch_repair_MutS_N	MSH3 MSH6	5.99e-05	2	145	2	IPR016151
Domain	-	MSH3 MSH6	5.99e-05	2	145	2	3.40.1170.10
Domain	PH	CDC42BPG PLEKHG4 DOCK11 DOCK9 FERMT1 PLEKHG5 SPTBN4 ANLN PHLPP1 PREX1	6.41e-05	278	145	10	SM00233
Domain	PH_DOMAIN	CDC42BPG PLEKHG4 DOCK11 DOCK9 FERMT1 PLEKHG5 SPTBN4 ANLN PHLPP1 PREX1	6.61e-05	279	145	10	PS50003
Domain	PH_domain	CDC42BPG PLEKHG4 DOCK11 DOCK9 FERMT1 PLEKHG5 SPTBN4 ANLN PHLPP1 PREX1	6.81e-05	280	145	10	IPR001849
Domain	PH	CDC42BPG PLEKHG4 DOCK11 DOCK9 FERMT1 SPTBN4 ANLN PHLPP1 PREX1	7.66e-05	229	145	9	PF00169
Domain	DNA_mismatch_repair_MutS-lik_N	MSH3 MSH6	1.79e-04	3	145	2	IPR007695
Domain	MutS_I	MSH3 MSH6	1.79e-04	3	145	2	PF01624
Domain	Stereocilin-rel	STRC MSLN	1.79e-04	3	145	2	IPR026664
Domain	-	CDC42BPG EPS8L2 PLEKHG4 DOCK11 DOCK9 FERMT1 PLEKHG5 SPTBN4 ANLN PHLPP1 PREX1	2.43e-04	391	145	11	2.30.29.30
Domain	LH2	LOXHD1 ALOX12 ALOX15	3.43e-04	18	145	3	SM00308
Domain	DNA_mmatch_repair_MutS_con_dom	MSH3 MSH6	3.56e-04	4	145	2	IPR007860
Domain	MutS_II	MSH3 MSH6	3.56e-04	4	145	2	PF05188
Domain	PP2C	PPM1M PPM1B PHLPP1	4.05e-04	19	145	3	PF00481
Domain	PP2Cc	PPM1M PPM1B PHLPP1	4.74e-04	20	145	3	SM00332
Domain	-	PPM1M PPM1B PHLPP1	4.74e-04	20	145	3	3.60.40.10
Domain	PPM-type_phosphatase_dom	PPM1M PPM1B PHLPP1	4.74e-04	20	145	3	IPR001932
Domain	PPM_2	PPM1M PPM1B PHLPP1	4.74e-04	20	145	3	PS51746
Domain	PH_dom-like	CDC42BPG EPS8L2 PLEKHG4 DOCK11 DOCK9 FERMT1 PLEKHG5 SPTBN4 ANLN PHLPP1 PREX1	5.01e-04	426	145	11	IPR011993
Domain	-	LOXHD1 ALOX12 ALOX15	5.50e-04	21	145	3	2.60.60.20
Domain	PLAT	LOXHD1 ALOX12 ALOX15	5.50e-04	21	145	3	PF01477
Domain	PLAT/LH2_dom	LOXHD1 ALOX12 ALOX15	5.50e-04	21	145	3	IPR001024
Domain	PLAT	LOXHD1 ALOX12 ALOX15	5.50e-04	21	145	3	PS50095
Domain	SRCR	SSC5D SSC4D CD5L	5.50e-04	21	145	3	PF00530
Domain	MUTSd	MSH3 MSH6	5.89e-04	5	145	2	SM00533
Domain	MUTSac	MSH3 MSH6	5.89e-04	5	145	2	SM00534
Domain	MutS_V	MSH3 MSH6	5.89e-04	5	145	2	PF00488
Domain	DNA_mismatch_repair_MutS_clamp	MSH3 MSH6	5.89e-04	5	145	2	IPR007861
Domain	DNA_MISMATCH_REPAIR_2	MSH3 MSH6	5.89e-04	5	145	2	PS00486
Domain	MutS_IV	MSH3 MSH6	5.89e-04	5	145	2	PF05190
Domain	MutS_III	MSH3 MSH6	5.89e-04	5	145	2	PF05192
Domain	DNA_mismatch_repair_MutS_C	MSH3 MSH6	5.89e-04	5	145	2	IPR000432
Domain	DNA_mismatch_repair_MutS_core	MSH3 MSH6	5.89e-04	5	145	2	IPR007696
Domain	Quinoprotein_ADH-like_supfam	WDR7 STAM EML5 MLST8	7.60e-04	53	145	4	IPR011047
Domain	LipOase_mml	ALOX12 ALOX15	8.80e-04	6	145	2	IPR001885
Domain	LIPOXYGENASE_1	ALOX12 ALOX15	8.80e-04	6	145	2	PS00711
Domain	LipOase_C	ALOX12 ALOX15	8.80e-04	6	145	2	IPR013819
Domain	LIPOXYGENASE_2	ALOX12 ALOX15	8.80e-04	6	145	2	PS00081
Domain	LipOase_Fe_BS	ALOX12 ALOX15	8.80e-04	6	145	2	IPR020833
Domain	LipOase_CS	ALOX12 ALOX15	8.80e-04	6	145	2	IPR020834
Domain	DUF3398	DOCK11 DOCK9	8.80e-04	6	145	2	PF11878
Domain	Lipoxygenase	ALOX12 ALOX15	8.80e-04	6	145	2	PF00305
Domain	LIPOXYGENASE_3	ALOX12 ALOX15	8.80e-04	6	145	2	PS51393
Domain	LipOase	ALOX12 ALOX15	8.80e-04	6	145	2	IPR000907
Domain	DOCK_C/D_N	DOCK11 DOCK9	8.80e-04	6	145	2	IPR021816
Domain	-	SSC5D SSC4D CD5L	9.30e-04	25	145	3	3.10.250.10
Domain	SR	SSC5D SSC4D CD5L	9.30e-04	25	145	3	SM00202
Domain	SRCR-like_dom	SSC5D SSC4D CD5L	1.05e-03	26	145	3	IPR017448
Domain	SRCR_1	SSC5D SSC4D CD5L	1.05e-03	26	145	3	PS00420
Domain	SRCR_2	SSC5D SSC4D CD5L	1.05e-03	26	145	3	PS50287
Domain	SRCR	SSC5D SSC4D CD5L	1.17e-03	27	145	3	IPR001190
Domain	A1pp	GDAP2 MACROD1	2.08e-03	9	145	2	SM00506
Domain	Macro	GDAP2 MACROD1	2.08e-03	9	145	2	PF01661
Domain	WD40_repeat_dom	WDR7 WRAP53 BRWD3 DENND3 WDR19 EML5 MLST8 HPS5	2.26e-03	297	145	8	IPR017986
Domain	Macro_dom	GDAP2 MACROD1	2.59e-03	10	145	2	IPR002589
Domain	MACRO	GDAP2 MACROD1	2.59e-03	10	145	2	PS51154
Domain	DHR-1_domain	DOCK11 DOCK9	3.14e-03	11	145	2	IPR027007
Domain	DHR_2	DOCK11 DOCK9	3.14e-03	11	145	2	PS51651
Domain	DHR_1	DOCK11 DOCK9	3.14e-03	11	145	2	PS51650
Domain	DHR-2	DOCK11 DOCK9	3.14e-03	11	145	2	PF06920
Domain	DOCK	DOCK11 DOCK9	3.14e-03	11	145	2	IPR026791
Domain	DOCK_C	DOCK11 DOCK9	3.14e-03	11	145	2	IPR010703
Domain	DOCK-C2	DOCK11 DOCK9	3.14e-03	11	145	2	PF14429
Domain	DHR-2	DOCK11 DOCK9	3.14e-03	11	145	2	IPR027357
Domain	PP2C_BS	PPM1M PPM1B	3.75e-03	12	145	2	IPR000222
Domain	WD40	WDR7 WRAP53 BRWD3 DENND3 WDR19 EML5 MLST8	4.15e-03	259	145	7	PF00400
Domain	SH3_2	RIMBP3 RIMBP3C MYO15A RIMBP3B	4.52e-03	86	145	4	PF07653
Domain	SH3_2	RIMBP3 RIMBP3C MYO15A RIMBP3B	4.52e-03	86	145	4	IPR011511
Domain	-	WDR7 WRAP53 BRWD3 DENND3 WDR19 EML5 MLST8 HPS5	4.53e-03	333	145	8	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	WDR7 WRAP53 BRWD3 DENND3 WDR19 EML5 MLST8 HPS5	4.70e-03	335	145	8	IPR015943
Domain	WD40	WDR7 WRAP53 BRWD3 DENND3 WDR19 EML5 MLST8	4.99e-03	268	145	7	SM00320
Domain	WD40_repeat	WDR7 WRAP53 BRWD3 DENND3 WDR19 EML5 MLST8	5.41e-03	272	145	7	IPR001680
Domain	PPM_1	PPM1M PPM1B	5.88e-03	15	145	2	PS01032
Domain	WD_REPEATS_1	WDR7 WRAP53 BRWD3 DENND3 WDR19 EML5 MLST8	6.07e-03	278	145	7	PS00678
Domain	WD_REPEATS_2	WDR7 WRAP53 BRWD3 DENND3 WDR19 EML5 MLST8	6.19e-03	279	145	7	PS50082
Domain	WD_REPEATS_REGION	WDR7 WRAP53 BRWD3 DENND3 WDR19 EML5 MLST8	6.19e-03	279	145	7	PS50294
Domain	SH3	EPS8L2 STAM RIMBP3 RIMBP3C MYO15A RIMBP3B	6.86e-03	216	145	6	SM00326
Domain	SH3	EPS8L2 STAM RIMBP3 RIMBP3C MYO15A RIMBP3B	6.86e-03	216	145	6	PS50002
Domain	SH3_domain	EPS8L2 STAM RIMBP3 RIMBP3C MYO15A RIMBP3B	7.48e-03	220	145	6	IPR001452
Domain	PP2C	PPM1M PPM1B	7.54e-03	17	145	2	IPR015655
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	RIN3 PDE4A B4GALNT4 LZTR1 SZT2 ESYT1 DOCK9 EXTL3 WRAP53 PLEKHG5 BANF1 SLC52A3 ZNF263 URB1 DEPDC5 PAX2 TANC1 DOT1L IL17RD DHX34 PREX1 TOP3A RAI1	4.45e-10	1105	150	23	35748872
Pubmed	Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes.	MSH3 MSH6 PCNA	7.86e-08	3	150	3	11005803
Pubmed	hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci.	MSH3 MSH6 PCNA	7.86e-08	3	150	3	11274057
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	3.14e-07	4	150	3	19091768
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	EPS8L2 TBRG4 TPCN2 PRR5L EMC4 PLEKHG4 DOCK9 PPM1M WRAP53 PLEKHG5 BANF1 USP19 ASB1 MLST8 MVK MSLN TEDC1	5.70e-07	925	150	17	28986522
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	7.81e-07	5	150	3	17855024
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	MIER2 WAPL ZNF680 POLA1 MSH3 MSH6 ANLN GLYR1 TIMELESS DOT1L MGA RAI1 KIFC1	2.58e-06	608	150	13	36089195
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	SZT2 USP19 KIF7 MSH6 DEPDC5 TIMELESS MLST8	3.71e-06	147	150	7	29576527
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	WDR7 PCLO EXTL3 URB1 PHLPP1 MGA	6.59e-06	105	150	6	9628581
Pubmed	Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in mouse islet β cells.	ALOX12 ALOX15	1.85e-05	2	150	2	30792307
Pubmed	Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis.	ALOX12 ALOX15	1.85e-05	2	150	2	25251155
Pubmed	A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense.	ALOX12 ALOX15	1.85e-05	2	150	2	15708862
Pubmed	Enhancement role of host 12/15-lipoxygenase in melanoma progression.	ALOX12 ALOX15	1.85e-05	2	150	2	23664097
Pubmed	Lipoxygenase metabolites are mediators of PTH-dependent human osteoblast growth.	ALOX12 ALOX15	1.85e-05	2	150	2	18187376
Pubmed	Polymorphisms in the human ALOX12 and ALOX15 genes are associated with peak bone mineral density in Chinese nuclear families.	ALOX12 ALOX15	1.85e-05	2	150	2	22089472
Pubmed	Msh3 is a limiting factor in the formation of intergenerational CTG expansions in DM1 transgenic mice.	MSH3 MSH6	1.85e-05	2	150	2	16552576
Pubmed	12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice.	ALOX12 ALOX15	1.85e-05	2	150	2	19787041
Pubmed	Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases.	ALOX12 ALOX15	1.85e-05	2	150	2	18547056
Pubmed	12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet.	ALOX12 ALOX15	1.85e-05	2	150	2	18780776
Pubmed	The mouse mismatch repair protein, MSH3, is a nucleoplasmic protein that aggregates into denser nuclear bodies under conditions of stress.	MSH3 PCNA	1.85e-05	2	150	2	21344488
Pubmed	Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification.	MSH3 MSH6	1.85e-05	2	150	2	15238604
Pubmed	A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination.	MSH3 MSH6	1.85e-05	2	150	2	15238605
Pubmed	The evolutionary hypothesis of reaction specificity of mammalian ALOX15 orthologs.	ALOX12 ALOX15	1.85e-05	2	150	2	30237084
Pubmed	Human ALOX12, but not ALOX15, is associated with BMD in white men and women.	ALOX12 ALOX15	1.85e-05	2	150	2	16598376
Pubmed	Expression of 12/15-lipoxygenase attenuates intracellular lipid deposition during in vitro foam cell formation.	ALOX12 ALOX15	1.85e-05	2	150	2	15681297
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	1.85e-05	2	150	2	34910522
Pubmed	Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis.	ALOX12 ALOX15	1.85e-05	2	150	2	29184033
Pubmed	Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice.	ALOX12 ALOX15	1.85e-05	2	150	2	10330425
Pubmed	Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.	ALOX12 ALOX15	1.85e-05	2	150	2	18755188
Pubmed	Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction.	ALOX12 ALOX15	1.85e-05	2	150	2	25293588
Pubmed	Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase.	ALOX12 ALOX15	1.85e-05	2	150	2	12731864
Pubmed	The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis.	ALOX12 ALOX15	1.85e-05	2	150	2	22267335
Pubmed	Overexpression of 12/15-lipoxygenase increases anxiety behavior in female mice.	ALOX12 ALOX15	1.85e-05	2	150	2	24300237
Pubmed	Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies.	ALOX12 ALOX15	1.85e-05	2	150	2	30472260
Pubmed	Glutathione disulfide induces neural cell death via a 12-lipoxygenase pathway.	ALOX12 ALOX15	1.85e-05	2	150	2	19373248
Pubmed	Role of Src tyrosine kinase in the atherogenic effects of the 12/15-lipoxygenase pathway in vascular smooth muscle cells.	ALOX12 ALOX15	1.85e-05	2	150	2	19095999
Pubmed	Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects.	ALOX12 ALOX15	1.85e-05	2	150	2	21094135
Pubmed	EGF stimulates lipoxin A4 synthesis and modulates repair in corneal epithelial cells through ERK and p38 activation.	ALOX12 ALOX15	1.85e-05	2	150	2	21220563
Pubmed	The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus.	MSH3 MSH6	1.85e-05	2	150	2	16618598
Pubmed	12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma.	ALOX12 ALOX15	1.85e-05	2	150	2	23528921
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	1.85e-05	2	150	2	11687802
Pubmed	Alox12/15 Deficiency Exacerbates, While Lipoxin A4 Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis.	ALOX12 ALOX15	1.85e-05	2	150	2	32760397
Pubmed	Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy.	ALOX12 ALOX15	1.85e-05	2	150	2	25187369
Pubmed	12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response.	ALOX12 ALOX15	1.85e-05	2	150	2	22215650
Pubmed	Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid.	ALOX12 ALOX15	1.85e-05	2	150	2	19469483
Pubmed	12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress.	ALOX12 ALOX15	1.85e-05	2	150	2	15111312
Pubmed	Polymorphisms in ALOX12, but not ALOX15, are significantly associated with BMD in postmenopausal women.	ALOX12 ALOX15	1.85e-05	2	150	2	17520163
Pubmed	Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase.	ALOX12 ALOX15	1.85e-05	2	150	2	20570249
Pubmed	Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators.	ALOX12 ALOX15	1.85e-05	2	150	2	32324389
Pubmed	Pancreatic metastases of renal clear cell carcinoma: a clinicopathological study of 11 cases with special emphasis on the usefulness of PAX2 and mesothelin for the distinction from primary ductal adenocarcinoma of the pancreas.	PAX2 MSLN	1.85e-05	2	150	2	24344503
Pubmed	Reactive oxygen species and 12/15-lipoxygenase contribute to the antiproliferative capacity of alternatively activated myeloid cells elicited during helminth infection.	ALOX12 ALOX15	1.85e-05	2	150	2	15879104
Pubmed	Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair.	MSH3 MSH6	1.85e-05	2	150	2	8782829
Pubmed	The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression.	MSH3 MSH6	1.85e-05	2	150	2	10706084
Pubmed	12-Lipoxygenase isoenzymes in mouse skin tumor development.	ALOX12 ALOX15	1.85e-05	2	150	2	7576099
Pubmed	The 12/15-lipoxygenase as an emerging therapeutic target for Alzheimer's disease.	ALOX12 ALOX15	1.85e-05	2	150	2	25708815
Pubmed	Primary renal hypoplasia in humans and mice with PAX2 mutations: evidence of increased apoptosis in fetal kidneys of Pax2(1Neu) +/- mutant mice.	PAX2 PCNA	1.85e-05	2	150	2	10587573
Pubmed	Lack of association of ALOX12 and ALOX15 polymorphisms with aspirin-exacerbated respiratory disease in Korean patients.	ALOX12 ALOX15	1.85e-05	2	150	2	19663136
Pubmed	12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis.	ALOX12 ALOX15	1.85e-05	2	150	2	19675173
Pubmed	Assessing the impact of MSH3 and MSH6 polymorphisms on lung cancer risk in North Indian patients undergoing platinum chemotherapy through molecular dynamics simulation.	MSH3 MSH6	1.85e-05	2	150	2	39003369
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	WAPL PRR5L CAND2 MAP6 DOCK9 DHDDS URB1 EML5 ANLN GLYR1 TIMELESS DOT1L IL17RD CCDC171 MGA CCDC85B	1.96e-05	1084	150	16	11544199
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	CDC42BPG TBC1D30 DOCK11 POLA1 DISC1 CANX PCLO MSH6 URB1 LOXHD1 EDAR TBK1 RAI1	1.98e-05	736	150	13	29676528
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	GPC1 WAPL PLEKHG4 POLA1 ESYT1 FERMT1 UBE2M MSH3 NCCRP1 MSH6 URB1 RNH1 ANLN GLYR1 TANC1 MGA DHX34 PCNA	2.31e-05	1353	150	18	29467282
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	CDC42BPG WAPL NOA1 DENND3 TBK1 TIMELESS TANC1 HPS5 ZBED1 DHX34 TOP3A KIFC1	2.72e-05	650	150	12	38777146
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	2.76e-05	14	150	3	17662146
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	CANX KIF7 MSH6 URB1 RNH1 GLYR1 TBK1 TIMELESS	3.55e-05	285	150	8	32838362
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DNHD1 TBRG4 WAPL NUDT21 POLA1 ESYT1 CANX PCLO UBE2M MSH3 USP19 PSMD6 MSH6 URB1 GLYR1 TBK1 PCNA KIFC1	4.53e-05	1425	150	18	30948266
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	GPC1 EPS8L2 NUDT21 NOA1 ESYT1 CANX UBE2M CNPY2 STAM PSMD6 CEP72 ANLN GUSB TBK1 MLST8 DNAJC3 PCNA	4.75e-05	1297	150	17	33545068
Pubmed	The variants in PTPRB, TRAF3IP3, and DISC1 genes were associated with Graves' disease in the Chinese population.	DISC1 TRAF3IP3	5.53e-05	3	150	2	36397361
Pubmed	Human 5-, 12- and 15-lipoxygenase-1 coexist in kidney but show opposite trends and their balance changes in cancer.	ALOX12 ALOX15	5.53e-05	3	150	2	22825379
Pubmed	5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy.	ALOX12 ALOX15	5.53e-05	3	150	2	18346986
Pubmed	Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis.	ALOX12 ALOX15	5.53e-05	3	150	2	22279185
Pubmed	Human cell DNA replication is mediated by a discrete multiprotein complex.	POLA1 PCNA	5.53e-05	3	150	2	11968016
Pubmed	Interplay between mismatch repair and chromatin assembly.	MSH6 PCNA	5.53e-05	3	150	2	22232658
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	5.53e-05	3	150	2	30801007
Pubmed	Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI).	ALOX12 ALOX15	5.53e-05	3	150	2	19752233
Pubmed	A diagnostic score for molecular analysis of hereditary autoinflammatory syndromes with periodic fever in children.	MEFV MVK	5.53e-05	3	150	2	18512793
Pubmed	Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages.	ALOX12 ALOX15	5.53e-05	3	150	2	18296557
Pubmed	Relationship between 12/15-lipoxygenase and COX-2 in mesangial cells: potential role in diabetic nephropathy.	ALOX12 ALOX15	5.53e-05	3	150	2	16514433
Pubmed	DNA mismatch repair proteins are required for efficient herpes simplex virus 1 replication.	MSH3 MSH6	5.53e-05	3	150	2	21957315
Pubmed	5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1.	ALOX12 ALOX15	5.53e-05	3	150	2	30407793
Pubmed	The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice.	ALOX12 ALOX15	5.53e-05	3	150	2	8944751
Pubmed	Multiple mutations and frameshifts are the hallmark of defective hPMS2 in pZ189-transfected human tumor cells.	MSH3 MSH6	5.53e-05	3	150	2	10871409
Pubmed	Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine.	ALOX12 ALOX15	5.53e-05	3	150	2	18311922
Pubmed	The distinct spectra of tumor-associated Apc mutations in mismatch repair-deficient Apc1638N mice define the roles of MSH3 and MSH6 in DNA repair and intestinal tumorigenesis.	MSH3 MSH6	5.53e-05	3	150	2	11691815
Pubmed	Effects of silencing leukocyte-type 12/15-lipoxygenase using short interfering RNAs.	ALOX12 ALOX15	5.53e-05	3	150	2	15576842
Pubmed	Interactions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: examination of mutations found in hereditary nonpolyposis colorectal cancer.	MSH3 MSH6	5.53e-05	3	150	2	9774676
Pubmed	Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins.	MSH3 MSH6	5.53e-05	3	150	2	11809728
Pubmed	PAX2 suppresses apoptosis in renal collecting duct cells.	PAX2 PCNA	5.53e-05	3	150	2	10980123
Pubmed	HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions.	MSH3 MSH6	5.53e-05	3	150	2	10545954
Pubmed	Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase.	ALOX12 ALOX15	5.53e-05	3	150	2	15328042
Pubmed	Roles of the DOCK-D family proteins in a mouse model of neuroinflammation.	DOCK11 DOCK9	5.53e-05	3	150	2	32241915
Pubmed	The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair.	MSH6 PCNA	5.53e-05	3	150	2	18326858
Pubmed	Smooth muscle-specific expression of calcium-independent phospholipase A2β (iPLA2β) participates in the initiation and early progression of vascular inflammation and neointima formation.	ALOX12 ALOX15	5.53e-05	3	150	2	22637477
Pubmed	Transcriptional regulation of β-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments.	ALOX12 ALOX15	5.53e-05	3	150	2	22275252
Pubmed	Mismatch repair polymorphisms and the risk of colorectal cancer.	MSH3 MSH6	5.53e-05	3	150	2	17205513
Pubmed	Transcription promotes contraction of CAG repeat tracts in human cells.	MSH3 MSH6	5.53e-05	3	150	2	16388310
Pubmed	MutSbeta exceeds MutSalpha in dinucleotide loop repair.	MSH3 MSH6	5.53e-05	3	150	2	20160730
Pubmed	Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling.	ALOX12 ALOX15	5.53e-05	3	150	2	23070608
Pubmed	Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity.	ALOX12 ALOX15	5.53e-05	3	150	2	30944221
Pubmed	Insulin-like growth factor I reduces lipid oxidation and foam cell formation via downregulation of 12/15-lipoxygenase.	ALOX12 ALOX15	5.53e-05	3	150	2	25549319
Interaction	APEX1 interactions	EPS8L2 TBRG4 WAPL TPCN2 PRR5L EMC4 PLEKHG4 DOCK9 PPM1M SIRT6 WRAP53 PLEKHG5 BANF1 USP19 URB1 ANLN GLYR1 ASB1 DOT1L MLST8 MGA MVK PCNA RAI1 MSLN TEDC1	1.38e-06	1271	146	26	int:APEX1
Interaction	S100A2 interactions	GPC1 TBC1D30 EMC4 WWP2 XRCC4 PPM1B TDRD7 PSMD6 RNH1 ANLN ZBED1 DHX34 RAI1	9.80e-06	412	146	13	int:S100A2
Interaction	MSH2 interactions	CANX UBE2M MSH3 EXTL3 SIRT6 TDRD7 MSH6 ZNF263 ANLN TOP3A PCNA	1.81e-05	313	146	11	int:MSH2
Interaction	TOP3B interactions	RIN3 PDE4A B4GALNT4 LZTR1 SZT2 NUDT21 ESYT1 DOCK9 MSH3 EXTL3 WRAP53 PLEKHG5 BANF1 SLC52A3 ZNF250 ZNF263 URB1 DEPDC5 PAX2 TANC1 DOT1L IL17RD DHX34 PREX1 TOP3A RAI1	1.88e-05	1470	146	26	int:TOP3B
Interaction	HUS1 interactions	WDR7 POLA1 MSH3 SIRT6 MSH6 TIMELESS PCNA	2.44e-05	118	146	7	int:HUS1
Interaction	PARP1 interactions	LZTR1 EMC4 POLA1 WWP2 CANX MACROD1 UBE2M MSH3 SIRT6 XRCC4 BANF1 PPM1B MSH6 URB1 RNH1 GLDC ANLN GLYR1 TIMELESS MGA TOP3A PCNA RAI1 KIFC1	2.53e-05	1316	146	24	int:PARP1
Cytoband	Ensembl 112 genes in cytogenetic band chr11q13	CDC42BPG TPCN2 MAP6 MACROD1 PGM2L1 BANF1 SLC22A20P CCDC85B	1.33e-04	454	150	8	chr11q13
Cytoband	22q11.21	LZTR1 RIMBP3 RIMBP3C RIMBP3B	5.00e-04	111	150	4	22q11.21
Cytoband	11p15.5	EPS8L2 B4GALNT4 ZNF195 RNH1	6.29e-04	118	150	4	11p15.5
Cytoband	1q21-q23	CD5L B4GALT3	8.08e-04	13	150	2	1q21-q23
Cytoband	11q13.1	CDC42BPG BANF1 SLC22A20P	1.18e-03	63	150	3	11q13.1
Cytoband	16p13.3	MEFV ZNF263 GLYR1 MLST8 MSLN	1.29e-03	244	150	5	16p13.3
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	CDC42BPG PLEKHG4 DOCK11 DOCK9 FERMT1 PLEKHG5 SPTBN4 ANLN PHLPP1 PREX1	1.05e-07	206	93	10	682
GeneFamily	Protein phosphatases, Mg2+/Mn2+ dependent	PPM1M PPM1B PHLPP1	8.50e-05	17	93	3	701
GeneFamily	MutS homologs\|PWWP domain containing	MSH3 MSH6	2.59e-04	5	93	2	1026
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	SSC5D SSC4D LY75	3.52e-04	27	93	3	1253
GeneFamily	Arachidonate lipoxygenases	ALOX12 ALOX15	3.87e-04	6	93	2	407
GeneFamily	WD repeat domain containing	WDR7 WRAP53 BRWD3 DENND3 WDR19 EML5 MLST8	4.06e-04	262	93	7	362
GeneFamily	Beta 4-glycosyltransferases	B4GALNT4 B4GALT3	3.39e-03	17	93	2	425
ToppCell	RV-08._Macrophage\|World / Chamber and Cluster_Paper	RIN3 DOCK11 EMB RGL1 ANLN AGFG1 PREX1	4.06e-06	192	150	7	a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCell	10x5'-Lung-Lymphocytic_T_CD4/8-lo-Trm_Tgd\|Lung / Manually curated celltypes from each tissue	DNHD1 LANCL3 EPS8L2 ZNF250 PREX1 MVK	2.20e-05	167	150	6	dcbcc658082910838c8082d71a64917055086cc4
ToppCell	10x3'2.3-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast-basophil\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	RIN3 PDE4A ESYT1 DEPDC5 IL17RD PREX1	2.95e-05	176	150	6	581d78811b2d99f38a2c7cc268aeb1cf932379c2
ToppCell	droplet-Fat-SCAT-30m-Lymphocytic-T_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	B4GALNT4 PGM2L1 RIMBP3 RAB36 TRAF3IP3 BTBD19	3.05e-05	177	150	6	baf78a8dad55f124f56585f88b10b58c0269680f
ToppCell	Control-Developping_Plasmablast\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	APOF GLDC ANLN HPGD PCNA KIFC1	3.25e-05	179	150	6	9383568f78b07b8cca72ece5d15fea209aa54ea9
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	POLA1 WRAP53 CCDC43 DOT1L DHX34 RAI1	3.67e-05	183	150	6	91079a11685dd466bd27a0cf5afbf3734c08a05e
ToppCell	CV-Healthy-7\|CV / Virus stimulation, Condition and Cluster	ZNF680 POLA1 DOCK9 DENND3 TOP3A RAI1	3.79e-05	184	150	6	0e5cc77aaa73ceb791f8be7456177577fd2e5586
ToppCell	TCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell-4\|TCGA-Uvea / Sample_Type by Project: Shred V9	PRR5L DOCK11 EMB DENND3 TBK1 BTBD19	3.79e-05	184	150	6	9c56753e5e668be888662e4713cf4ce44e6c58fb
ToppCell	CV-Healthy-7\|Healthy / Virus stimulation, Condition and Cluster	ZNF680 POLA1 DOCK9 URB1 TOP3A RAI1	3.90e-05	185	150	6	1979d189c204f4c2893e3170a514ee7d5523406c
ToppCell	droplet-Bladder-BLADDER-1m-Hematologic-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIN3 DOCK11 EMB NCCRP1 TIMELESS PREX1	3.90e-05	185	150	6	969248b63d4ce335f223528de756bcddffadbd77
ToppCell	(05)_Ciliated-(3)_72hpi\|(05)_Ciliated / shred by cell type and Timepoint	DENND3 ZNF263 ANLN PREX1 KIFC1	4.05e-05	113	150	5	eaa5bc8f8183b353ee1e7618e99220eb3684cd60
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SZT2 ESYT1 DOCK9 DHDDS HPGD PREX1	4.14e-05	187	150	6	3699d5e71d779da922920aa3160895db187bf81b
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SZT2 ESYT1 DOCK9 DHDDS HPGD PREX1	4.14e-05	187	150	6	033ba52c0c2f9978784947098fa697368ae44834
ToppCell	3'_v3-blood-Lymphocytic_T_CD4/8-lo-Cycling_T\|blood / Manually curated celltypes from each tissue	ESYT1 FERMT1 ANLN TIMELESS PCNA KIFC1	4.27e-05	188	150	6	714ccbcf826f26d39757931a3b8abbd952f4cddc
ToppCell	COVID-19-Heart-Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RIN3 DOCK11 EMB DISC1 RGL1 AGFG1	4.40e-05	189	150	6	2586f4088721c5debec86c2b211b739fd33713eb
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CAPS PGM2L1 RAB36 ANLN CCDC171 MSLN	4.53e-05	190	150	6	0adb24dafa077156bbc73a8d8cbf3d9eeb6e08df
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CAPS PGM2L1 RAB36 ANLN CCDC171 MSLN	4.53e-05	190	150	6	05455775845f4ded5c27e7b83242078d23162aaf
ToppCell	LV-08._Macrophage\|World / Chamber and Cluster_Paper	RIN3 DOCK11 EMB RGL1 AGFG1 PREX1	4.66e-05	191	150	6	e7a0bc46ba9ba772636a583f3387748418e18832
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RIN3 PDE4A DOCK11 EMB TRAF3IP3 PREX1	4.66e-05	191	150	6	468b5149d1533f03521844d3cce8633d44eb6ed4
ToppCell	RV-08._Macrophage\|RV / Chamber and Cluster_Paper	RIN3 DOCK11 EMB ANLN AGFG1 PREX1	4.94e-05	193	150	6	12bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCell	Control-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	RIN3 TBC1D30 MEFV DENND3 TRAF3IP3 CHST7	4.94e-05	193	150	6	3479c01aaae7afd7e02d00e0cb21951c0106a0fd
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1\|TCGA-Endometrium / Sample_Type by Project: Shred V9	NUDT21 POLA1 EXTL3 IL17RD TOP3A PCNA	4.94e-05	193	150	6	c2673d86f7d7b849788036032a93a6d136a70040
ToppCell	LA-08._Macrophage\|World / Chamber and Cluster_Paper	RIN3 DOCK11 EMB RGL1 AGFG1 PREX1	5.08e-05	194	150	6	c1805572bcc11b1cd29083329d7b5911489fb758
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RIN3 EMB DISC1 PLEKHG5 RGL1 PREX1	5.08e-05	194	150	6	1dce6d4b6ac41f80677e3e4c335a4f383bd76f85
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RIN3 DOCK11 EMB DISC1 RGL1 PREX1	5.08e-05	194	150	6	c95d5c4ad0210ebd672926558cc8331e6396a854
ToppCell	Control-Myeloid-ncMonocyte\|Control / Disease state, Lineage and Cell class	RIN3 TBC1D30 MEFV DENND3 TRAF3IP3 CHST7	5.23e-05	195	150	6	fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RIN3 DOCK11 EMB DISC1 TRAF3IP3 PREX1	5.23e-05	195	150	6	7b6c69df943842b566a596e30bb50dbe80dccc83
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RIN3 DOCK11 EMB DISC1 TRAF3IP3 PREX1	5.53e-05	197	150	6	61ef3f417767c3f5296a26399da63e3e4f58faf8
ToppCell	critical-Epithelial-FOXN4+\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PGM2L1 ANLN CCDC171 ALOX15 PCNA MSLN	5.69e-05	198	150	6	6b160b3d6a2c1b1641c2c7dcec1a7ef38411fec9
ToppCell	Caecum\|World / Region, Cell class and subclass	PDE4A CANX CNPY2 HPGD ZSWIM4 DNAJC3	6.02e-05	200	150	6	f8e3285f5ea7fef1b7b7089bd8b0f1ddb0625dfb
ToppCell	COVID_non-vent-Lymphocytic-Proliferative_Lymphocyte-\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	POLA1 MSH6 ANLN TIMELESS PCNA KIFC1	6.02e-05	200	150	6	04bf9e6a0fbd792b49eed63dabba5d6fafed8c07
ToppCell	COVID_vent-Lymphocytic-Proliferative_Lymphocyte-\|COVID_vent / Disease condition, Lineage, Cell class and subclass	POLA1 MSH6 ANLN TIMELESS PCNA KIFC1	6.02e-05	200	150	6	7e4c0db43a03ca11380a54f44a3cf1991e055b80
ToppCell	Parenchyma_Control_(B.)\|World / Sample group, Lineage and Cell type	DOCK11 UBE2M CD5L ABHD5 HPGD AGFG1	6.02e-05	200	150	6	220b6e5f936b3d08b031d6cabc5793213b98b8e2
ToppCell	COVID_non-vent-Lymphocytic-Proliferative_Lymphocyte\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	POLA1 MSH6 ANLN TIMELESS PCNA KIFC1	6.02e-05	200	150	6	f6b5320cdfe640a71e6e2df26f30d42e64b1c921
ToppCell	mLN-Dendritic_cell-Lymphoid_DC\|Dendritic_cell / Region, Cell class and subclass	NCCRP1 PPM1B TBK1 LY75 CHST7 DHX34	6.02e-05	200	150	6	3813fa1ee1462ba83fd8b6253070f46f0b063084
ToppCell	Caecum\|World / shred on region, Cell_type, and subtype	PDE4A CANX CNPY2 HPGD ZSWIM4 DNAJC3	6.02e-05	200	150	6	b46601ca1e949c825309484308c8f53e484b65cd
ToppCell	COVID_vent-Lymphocytic-Proliferative_Lymphocyte\|COVID_vent / Disease condition, Lineage, Cell class and subclass	POLA1 MSH6 ANLN TIMELESS PCNA KIFC1	6.02e-05	200	150	6	9775ca7dedb76fcbb74f80f86b33c94e394c320a
Drug	trichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A	PDE4A PCLO BBS9 DENND3 WDR19 RGL1 URB1 SMPD3 PADI3	3.65e-06	187	147	9	5976_UP
Drug	Brompheniramine maleate [980-71-2]; Down 200; 9.2uM; MCF7; HT_HG-U133A	GPC1 RIN3 DISC1 PCLO EXTL3 XRCC4 BBS9 HPGD TIMELESS	5.81e-06	198	147	9	4131_DN
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	2.17e-05	2	138	2	DOID:0110471 (implicated_via_orthology)
Disease	Endometrial cancer	MSH3 MSH6	1.29e-04	4	138	2	cv:C0007103
Disease	ENDOMETRIAL CANCER	MSH3 MSH6	1.29e-04	4	138	2	608089
Disease	Endometrial carcinoma	MSH3 MSH6	1.29e-04	4	138	2	cv:C0476089
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	MSH3 XRCC4 MSH6	2.41e-04	26	138	3	C0009405
Disease	Hereditary non-polyposis colorectal cancer syndrome	MSH3 XRCC4 MSH6	2.70e-04	27	138	3	C1112155
Disease	Hyalinosis, Segmental Glomerular	ANLN PAX2 PCNA	3.01e-04	28	138	3	C0086432
Disease	Hereditary Nonpolyposis Colorectal Cancer	MSH3 XRCC4 MSH6	3.35e-04	29	138	3	C1333990
Disease	Hereditary Autoinflammatory Diseases	MEFV MVK	4.49e-04	7	138	2	C0751422
Disease	Nonsyndromic Deafness	EPS8L2 LOXHD1 STRC MYO15A	5.77e-04	81	138	4	C3711374
Disease	Autoinflammatory disorder	POLA1 MEFV MVK	5.87e-04	35	138	3	C3860213
Disease	PARTINGTON X-LINKED MENTAL RETARDATION SYNDROME	POLA1 BRWD3	5.97e-04	8	138	2	C0796250
Disease	endometrial cancer (is_implicated_in)	SHBG MSH3 MSH6	6.38e-04	36	138	3	DOID:1380 (is_implicated_in)
Disease	Focal glomerulosclerosis	ANLN PAX2 PCNA	6.38e-04	36	138	3	C0017668
Disease	Inherited focal segmental glomerulosclerosis	ANLN PAX2	9.53e-04	10	138	2	cv:CN327126
Disease	Focal segmental glomerulosclerosis	ANLN PAX2	9.53e-04	10	138	2	cv:C0017668
Disease	immunoglobulin isotype switching measurement	RIN3 EMB TEDC1	1.15e-03	44	138	3	EFO_0010128
Disease	Hereditary Nephrotic Syndromes, Autosomal Dominant	ANLN PAX2	1.16e-03	11	138	2	cv:CN043612
Disease	forced expiratory volume	RIN3 WWP2 DOCK9 DHDDS BBS9 SSC5D EDAR CEP72 ERCC6L2 IL17RD PREX1	1.24e-03	789	138	11	EFO_0004314
Disease	Familial idiopathic steroid-resistant nephrotic syndrome	ANLN PAX2	1.64e-03	13	138	2	cv:C4273714
Disease	Nonsyndromic Hearing Loss and Deafness, Autosomal Recessive	LOXHD1 STRC MYO15A	1.77e-03	51	138	3	cv:CN043650
Disease	inflammatory biomarker measurement, YKL40 measurement	MSH6 ABHD5 PHLPP1	1.77e-03	51	138	3	EFO_0004869, EFO_0004872
Disease	waist-hip ratio	PRR5L CAND2 WWP2 SHBG MACROD1 MEFV TDRD7 SSC5D ABHD5 DNAH17 ASB1 DOT1L IL17RD CCDC171	1.86e-03	1226	138	14	EFO_0004343
Disease	Replication Error Phenotype	MSH3 MSH6	2.19e-03	15	138	2	C1721098
Disease	Microsatellite Instability	MSH3 MSH6	2.19e-03	15	138	2	C0920269
Disease	P wave duration	CAND2 EMB	2.19e-03	15	138	2	EFO_0005094
Disease	Bardet-Biedl syndrome 1 (disorder)	BBS9 KIF7	2.82e-03	17	138	2	C2936862
Disease	Hydrops Fetalis	LZTR1 GUSB	3.52e-03	19	138	2	C0020305
Disease	Hereditary Non-Polyposis Colon Cancer Type 2	MSH3 XRCC4	3.52e-03	19	138	2	C1333991
Disease	Colorectal cancer, hereditary nonpolyposis, type 1	MSH3 XRCC4	3.52e-03	19	138	2	C2936783
Disease	polychlorinated biphenyls measurement	EMB C6orf118 GLDC	3.54e-03	65	138	3	EFO_0007042
Disease	mitochondrial DNA measurement	TBRG4 DHDDS PAX2 LY75 TOP3A RAI1	4.55e-03	328	138	6	EFO_0006312

Protein segments in the cluster

Peptide	Gene	Start	Entry
SELLVADQLCLDRWF	ESYT1	881	Q9BSJ8
NVGVREALRDEEWDC	B4GALT3	176	O60512
CLQALWLREAQLEAA	C1orf167	546	Q5SNV9
CWQKLAELEGRQEEL	CCDC85B	116	Q15834
LVLDQAEAEGVCRKW	CAPS	141	Q13938
AQELAWCVEQLELGL	C8orf33	111	Q9H7E9
VDRGLFEDKVANIWC	ALG6	266	Q9Y672
LRNALEEAGCQADVW	APOF	91	Q13790
AGRNLKEWLREQFCD	ASB1	16	Q9Y576
WSELCAVLQENVDAL	CCDC171	596	Q6TFL3
ARWAILLEEIDCTEE	FERMT1	296	Q9BQL6
DCLVKIWATDDGRLL	BRWD3	201	Q6RI45
DGWDIKDVAVLCREL	CD5L	51	O43866
AVLNLIAECEWDLGR	CEP72	196	Q9P209
ELLDEWLALCRGFQE	DNHD1	3461	Q96M86
KARCEELQLDWATLS	DOT1L	601	Q8TEK3
WLGLEEACQLAQFKE	NUDT2	116	P50583
DSRFWELRDSIVQCE	CCNQ	111	Q8N1B3
EEEQLWAACAGRSEV	DENND3	1086	A2RUS2
WDAELRELRAECFIK	DNAJC3	186	Q13217
LLGKVWEADLEACRL	DISC1	686	Q9NRI5
WEADLEACRLLIQSL	DISC1	691	Q9NRI5
LQCPEVAKADRWLED	RAI1	826	Q7Z5J4
QWLEDALRENEAGSC	RAB36	216	O95755
SILRAWLDQCAEDFR	RGL1	146	Q9NZL6
QELAEAWEGCRKDLL	RIMBP3B	1276	A6NNM3
QELAEAWEGCRKDLL	RIMBP3C	1276	A6NJZ7
WQVLDGAEDTLRECR	HDHD3	111	Q9BSH5
AWAALERKLQCLEQE	CDC42BPG	411	Q6DT37
DSLLNICKEIVERWS	CCDC43	71	Q96MW1
LDVDVNNRTDRLEWC	DEPDC5	1356	O75140
RWLCQARSEDLSDIA	GDAP2	321	Q9NXN4
REQLVLDCSAEWLDF	MSH3	796	P20585
LDLWEDFSLCREGQR	IL17RD	391	Q8NFM7
GLQDRELTCWEEVAQ	LZTR1	206	Q8N653
CIARFWNQLDKADIA	MAP6	11	Q96JE9
DCNWEEDRNKILSIL	MGA	1341	Q8IWI9
RCQVEGALLWEQEEL	MYO15A	1976	Q9UKN7
LKGCLANQADLDAEW	GPC1	276	P35052
RLANLAATICSWEDD	ANLN	201	Q9NQW6
LDAVESLCADILEWA	EDAR	421	Q9UNE0
DRAWSLLQECGLALE	HPS5	1076	Q9UPZ3
LSKVEGDRQWCRDLL	LOXHD1	146	Q8IVV2
CQRWLAVEEDDGQLS	LOXHD1	916	Q8IVV2
QQCVDLLAEGLWEEL	NCCRP1	156	Q6ZVX7
AWDLKGQLCDLNAEL	KIFC1	136	Q9BW19
DNLARLWCVETGEIK	MLST8	291	Q9BVC4
LIGEACIWLDKVDLR	PCLO	5111	Q9Y6V0
LEALKDLINEACWDI	PCNA	16	P12004
DRLAAAELQENGCWK	PGM2L1	336	Q6PCE3
TCQQLARETLEELDW	PDE4A	226	P27815
WNRTAEKCDLFIQEG	GLYR1	296	Q49A26
AARKVRDWLCAVEGE	KIF7	436	Q2M1P5
TLNNILACRWDLEDE	MYLK4	311	Q86YV6
AKRLIDACARAEEWG	LANCL3	96	Q6ZV70
LNVLTCWKDLDDFNR	ALOX15	191	P16050
RWAETNGQLEDCVVL	LY75	1186	O60449
WELEACVDAALLATQ	MSLN	321	Q13421
CQSEWELLQDIGDIL	MEFV	521	O15553
LVDDAWFCDRITVQG	ALOX12	71	P18054
SCIDWNREVLKRELG	PADI3	546	Q9ULW8
DWQSAVECIAVLDVL	MSH6	1046	P52701
IRCGQLDLLQDWLAD	SMPD3	471	Q9NY59
GLDIVRRDWCDLAKD	POLA1	1076	P09884
CALDDIEWFVARLQK	EPS8L2	261	Q9H6S3
DWTLNIGEQALDICI	BBS9	236	Q3SYG4
AWEIRDRLLAEGICD	PAX2	111	Q02962
CEGENRIEVLAEVWD	PRR5L	116	Q6MZQ0
LCVDEAELVRAARSW	BTBD19	186	C9JJ37
LELLEQCVDGLWKAE	DOCK11	1696	Q5JSL3
ELLEQCADGLWKAER	DOCK9	1716	Q9BZ29
ECDLSGQVEVWLNRV	DNAH17	1646	Q9UFH2
EWALCGEREDRLELL	EXTL3	411	O43909
RECKELDGLWSFRAD	GUSB	36	P08236
CRALVDELEWEIAQV	CNPY2	31	Q9Y2B0
DNFIICADRRIVDDW	CANX	436	P27824
RCEILSKWDEIQALE	C6orf118	396	Q5T5N4
CEAAAEIVLATLREW	MACROD1	276	Q9BQ69
KDGIVALWDDSFERC	EML5	921	Q05BV3
QLLEEDGESYWCRAL	EMB	226	Q6PCB8
DRILVEKRCWDIALG	EMC4	61	Q5J8M3
RQDGVLQDWVIDDCI	NUDT21	131	O43809
RLCLDELNSLEWSAV	ERCC6L2	266	Q5T890
EDLFREWLKDTCGAN	BANF1	56	O75531
DIWALLFQRCEGAEE	CAND2	936	O75155
DCSRLVADGWLELQL	DHX34	916	Q14147
EGELSLWERFCANII	DHDDS	6	Q86SQ9
WDLVCEARTLRDLAQ	SLC22A20P	126	A6NK97
EAVDEGLVRKCTEWL	PRR18	256	Q8N4B5
ERLWEDCARAGLLLA	NOA1	266	Q8NC60
ALCKSLDWQIDVDLL	PSMD6	56	Q15008
DLVWALCVLQQAREA	TBRG4	411	Q969Z0
NVKVIRDGLCAWSEE	MIER2	291	Q8N344
CEIELSVGNDRLWFV	RIN3	221	Q8TB24
DWNLEAGVQCKAALD	HPGD	36	P15428
CNSLLVAESEEDLWR	SZT2	1981	Q5T011
RCWEASVEDLLNDQV	SLC52A3	246	Q9NQ40
ARKDAELLCWDLRQS	WRAP53	386	Q9BUR4
RCQDTWLALDQKLEA	PLEKHG4	631	Q58EX7
QELAEAWEGCRKDLL	RIMBP3	1276	Q9UFD9
EEQEALCLDLWGTER	RIMBP3	1381	Q9UFD9
ENSDIKICALGEEWR	GMCL2	106	Q8NEA9
WLLAQGDCQTREEAV	PREX1	551	Q8TCU6
DGCLRRDSWLDKQAE	SHBG	191	P04278
EERINLWCDIQDGTI	SHCBP1L	281	Q9BZQ2
LVWRADGENTAFLCE	TANC1	821	Q9C0D5
ILNDEAAWNELARAC	WDR19	671	Q8NEZ3
RLEVSDDLENVCNWV	PPM1B	261	O75688
DAVLWLRDSVLNCSD	TDRD7	786	Q8NHU6
TVCDDGWDLRDAAVA	SSC5D	221	A1L4H1
DAWDLRDAAVACREL	SSC5D	331	A1L4H1
ACRGELRDTILDWED	SIRT6	176	Q8N6T7
AALEGSAEELCAWRR	URB1	1366	O60287
NLGDKAVEWESQRLC	URB1	1886	O60287
NETLWAERLCGEASL	STRC	476	Q7RTU9
FVESIEEWRCALGLD	ABHD5	131	Q8WTS1
VDFELLRSDWNDLRC	B4GALNT4	691	Q76KP1
LFVAGERCDVETLEW	ACSS3	421	Q9H6R3
NEVCKQIWLGLFDDR	AGFG1	86	P52594
LTGALEVICEAWLRD	CHST7	341	Q9NS84
DWIALDADAVVVLCE	NLRP9	921	Q7RTR0
NACLRLEDSWRELID	PLEKHG5	311	O94827
RSLALAEQKCEEWRS	TRAF3IP3	306	Q9Y228
WLQNCLIRAADDREE	TIMELESS	1021	Q9UNS1
LELGDDCSLALVWRN	USP19	1011	O94966
ILDADGSWLECDDLK	USPL1	461	Q5W0Q7
VWIKENNLEECGLEL	WWP2	656	O00308
DVAVLLSQDEWDRLC	ZNF250	26	P15622
FSQEEWGLLDEAQRC	ZNF549	36	Q6P9A3
RGLACFQDWVEAADI	NXNL2	136	Q5VZ03
TVCDDAWDLRAAGVL	SSC4D	496	Q8WTU2
GDCVNRWTKEDLELI	MVK	171	Q03426
IRRCEFGAEEEWLTL	PPM1M	96	Q96MI6
AVEKELGALQQCWER	TEDC1	406	Q86SX3
LLRDWNDVQGRFEKC	XRCC4	151	Q13426
EEKLVASLWGAERCL	WAPL	841	Q7Z5K2
VLRVLWLADCDVSDS	RNH1	371	P13489
LQGWKELLSACEDAR	SPTBN4	1921	Q9H254
NTAEDWGLILDICDK	STAM	21	Q92783
LAIWAKLGEQIECCE	TBC1D30	466	Q9Y2I9
LADARCWELSAGDIK	PTH2R	301	P49190
QALVIWTDCDREGEN	TOP3A	141	Q13472
RDVALEFSLEEWQCL	ZNF98	16	A6NK75
EWVCESRKLEVLDIG	PHLPP1	911	O60346
NETLWAERLCGEASL	STRCP1	476	A6NGW2
REVILKELAEATWCG	ZBED1	181	O96006
WQDRCLEVREAAQAL	WDR7	1016	Q9Y4E6
LEGNVCLNILREDWK	UBE2M	106	P61081
RDVAIEFSLEEWQCL	ZNF680	16	Q8NEM1
IEFSLEEWKCLDLAQ	ZNF195	11	O14628
RWDLCIDQAVVFIED	TPCN2	41	Q8NHX9
LANILEADQEKCWGF	TBK1	281	Q9UHD2
LQLDTSRREELWACA	ZSWIM4	741	Q9H7M6
EGLLIVKLEEDCAWS	ZNF263	11	O14978
VNEKDLDDLLWIFGC	GLDC	476	P23378