Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

NRIP2 ERVK-6 ERVK-7 ERVK-9 ERVK-10 ERVK-8 ERVK-19 ERVK-24

1.77e-11371078GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

NRIP2 ERVK-6 ERVK-7 ERVK-9 ERVK-10 ERVK-8 ERVK-19 ERVK-24

2.23e-11381078GO:0070001
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8

2.50e-07111074GO:0004523
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8

7.48e-07141074GO:0003964
GeneOntologyMolecularFunctionnucleotidyltransferase activity

GPHN ERVK-6 POLG OAS3 ERVK-7 ERVK-10 ERVK-8 GDPGP1

1.62e-061521078GO:0016779
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-6 POLG ERVK-7 ERVK-10 ERVK-8

1.75e-06381075GO:0034061
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-6 ERVK-7 ERVK-10 ERVK-8

4.35e-06211074GO:0035613
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

ERVK-6 ERCC1 POLG ERVK-7 ERVK-10 SRCAP MAP1S G3BP1 ERVK-8

1.18e-052621079GO:0140097
GeneOntologyMolecularFunctionnuclease activity

ERVK-6 ERCC1 POLG ERVK-7 ERVK-10 MAP1S G3BP1 ERVK-8

3.46e-052311078GO:0004518
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-6 ERVK-7 ERVK-10 ERVK-8

4.49e-05371074GO:0016891
GeneOntologyMolecularFunctionendonuclease activity

ERVK-6 ERCC1 ERVK-7 ERVK-10 G3BP1 ERVK-8

9.19e-051361076GO:0004519
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-6 ERVK-7 ERVK-10 ERVK-8

1.07e-04461074GO:0016893
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

ERVK-6 ERCC1 POLG ERVK-7 ERVK-10 SRCAP MRM3 METTL25B MAP1S G3BP1 ERVK-8 DDX23

1.76e-0464510712GO:0140640
GeneOntologyMolecularFunctionendopeptidase activity

NRIP2 ERVK-6 KLK14 ERVK-7 ERVK-9 ERVK-10 ERVK-8 ERVK-19 ERVK-24

5.11e-044301079GO:0004175
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8

8.60e-04791074GO:0004521
GeneOntologyMolecularFunctioncomplement component C1q complex binding

C4A C4B

1.24e-03101072GO:0001849
GeneOntologyMolecularFunctionhydrolase activity, acting on ester bonds

ERVK-6 PNPLA2 PDE2A ERCC1 POLG ERVK-7 ERVK-10 GDPD5 ARSF MAP1S G3BP1 ERVK-8

1.29e-0380710712GO:0016788
GeneOntologyMolecularFunctionmolecular condensate scaffold activity

NLRP6 G3BP1 CAPRIN1

1.48e-03421073GO:0140693
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

EPHB2 GPHN ERVK-6 WEE1 POLG SIK1 OAS3 ERVK-7 ERVK-10 NRK ERVK-8 GDPGP1 MAP4K2

1.52e-0393810713GO:0016772
GeneOntologyMolecularFunctioncatalytic activity, acting on RNA

ERVK-6 ERVK-7 ERVK-10 MRM3 METTL25B G3BP1 ERVK-8 DDX23

1.82e-034171078GO:0140098
GeneOntologyBiologicalProcessDNA integration

ERVK-6 ERVK-7 ERVK-10 ERVK-8

4.38e-07131054GO:0015074
DomainZnF_C2HC

ERVK-6 FAM90A14 FAM90A1 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A10

3.93e-1055978SM00343
DomainZnf_CCHC

ERVK-6 FAM90A14 FAM90A1 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A10

3.93e-1055978IPR001878
DomainPAX

PAX1 PAX2 PAX5 PAX9

8.44e-089974SM00351
DomainPaired_dom

PAX1 PAX2 PAX5 PAX9

8.44e-089974IPR001523
DomainPAIRED_2

PAX1 PAX2 PAX5 PAX9

8.44e-089974PS51057
DomainPAX

PAX1 PAX2 PAX5 PAX9

8.44e-089974PF00292
DomainPAIRED_1

PAX1 PAX2 PAX5 PAX9

8.44e-089974PS00034
DomainPax2_C

PAX2 PAX5

7.98e-053972IPR022130
DomainPax2_C

PAX2 PAX5

7.98e-053972PF12403
DomainAnaphylatoxin_comp_syst

C4A C4B

2.64e-045972IPR018081
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

2.64e-045972IPR001840
DomainEGF_2

EPHB2 VASN LAMB3 MATN4 ITGB7 CELSR3 UMODL1

4.64e-04265977PS01186
DomainANATO

C4A C4B

5.51e-047972SM00104
DomainANATO

C4A C4B

5.51e-047972PF01821
DomainANAPHYLATOXIN_2

C4A C4B

5.51e-047972PS01178
DomainANAPHYLATOXIN_1

C4A C4B

5.51e-047972PS01177
DomainAnaphylatoxin/fibulin

C4A C4B

5.51e-047972IPR000020
DomainThiol-ester_cl

C4A C4B

7.32e-048972PF10569
DomainMacrogloblnA2_thiol-ester-bond

C4A C4B

7.32e-048972IPR019565
DomainMacrogloblnA2_CS

C4A C4B

7.32e-048972IPR019742
DomainCadherin_tail

PCDHGB7 PCDHGB6 PCDHGA12

9.28e-0437973PF15974
DomainCadherin_CBD

PCDHGB7 PCDHGB6 PCDHGA12

9.28e-0437973IPR031904
DomainA2M_N

C4A C4B

1.17e-0310972PF01835
DomainA2M_N

C4A C4B

1.17e-0310972IPR002890
DomainA-macroglobulin_rcpt-bd

C4A C4B

1.17e-0310972IPR009048
DomainALPHA_2_MACROGLOBULIN

C4A C4B

1.17e-0310972PS00477
DomainA2M

C4A C4B

1.17e-0310972PF00207
DomainA2M_N_2

C4A C4B

1.17e-0310972IPR011625
DomainA2M_comp

C4A C4B

1.17e-0310972IPR011626
DomainA2M_N_2

C4A C4B

1.17e-0310972PF07703
DomainA2M_recep

C4A C4B

1.17e-0310972PF07677
DomainA2M_comp

C4A C4B

1.17e-0310972PF07678
DomainMacroglobln_a2

C4A C4B

1.17e-0310972IPR001599
DomainCadherin_C

PCDHGB7 PCDHGB6 PCDHGA12

1.35e-0342973IPR032455
DomainCadherin_C_2

PCDHGB7 PCDHGB6 PCDHGA12

1.35e-0342973PF16492
DomainHomeodomain-like

TPRX1 PAX1 PAX2 DNAJC1 PAX5 SNAPC2 PAX9

1.72e-03332977IPR009057
DomainAspartic_peptidase_AS

NRIP2 ERVK-6

2.01e-0313972IPR001969
DomainEGF_1

VASN LAMB3 MATN4 ITGB7 CELSR3 UMODL1

2.14e-03255976PS00022
DomainCNH

NRK MAP4K2

2.33e-0314972SM00036
DomainEGF-like_CS

VASN LAMB3 MATN4 ITGB7 CELSR3 UMODL1

2.41e-03261976IPR013032
DomainCadherin_CS

PCDHGB7 PCDHGB6 CELSR3 PCDHGA12

2.51e-03109974IPR020894
DomainCNH

NRK MAP4K2

2.68e-0315972PF00780
DomainCNH

NRK MAP4K2

2.68e-0315972PS50219
DomainCNH_dom

NRK MAP4K2

2.68e-0315972IPR001180
DomainCADHERIN_1

PCDHGB7 PCDHGB6 CELSR3 PCDHGA12

2.86e-03113974PS00232
DomainCadherin

PCDHGB7 PCDHGB6 CELSR3 PCDHGA12

2.86e-03113974PF00028
DomainCADHERIN_2

PCDHGB7 PCDHGB6 CELSR3 PCDHGA12

2.95e-03114974PS50268
Domain-

PCDHGB7 PCDHGB6 CELSR3 PCDHGA12

2.95e-031149742.60.40.60
DomainCA

PCDHGB7 PCDHGB6 CELSR3 PCDHGA12

3.04e-03115974SM00112
DomainCadherin-like

PCDHGB7 PCDHGB6 CELSR3 PCDHGA12

3.14e-03116974IPR015919
DomainCadherin

PCDHGB7 PCDHGB6 CELSR3 PCDHGA12

3.34e-03118974IPR002126
DomainC345C

C4A C4B

3.45e-0317972SM00643
DomainTerpenoid_cyclase/PrenylTrfase

C4A C4B

3.87e-0318972IPR008930
DomainNTR

C4A C4B

4.31e-0319972PF01759
DomainNetrin_module_non-TIMP

C4A C4B

4.31e-0319972IPR018933
DomainCadherin_2

PCDHGB7 PCDHGB6 PCDHGA12

4.70e-0365973PF08266
DomainCadherin_N

PCDHGB7 PCDHGB6 PCDHGA12

4.70e-0365973IPR013164
Pubmed

Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events.

FAM90A14 FAM90A2P FAM90A1 FAM90A17 FAM90A19 FAM90A23 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10

3.04e-24251111217684299
Pubmed

Analysis of the multi-copy gene family FAM90A as a copy number variant in different ethnic backgrounds.

FAM90A14 FAM90A2P FAM90A17 FAM90A19 FAM90A23 FAM90A7 FAM90A9 FAM90A8 FAM90A16 FAM90A10

8.00e-20231111018602769
Pubmed

Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.

FAM90A14 VASN FAM90A1 FAM90A17 FAM90A19 FAM90A26 FAM90A23 FAM90A7 FAM90A9 FAM90A8 FAM90A10

5.76e-121641111122967998
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-6 ERVK-7 ERVK-10 ERVK-24

9.83e-114111410469592
Pubmed

Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9.

PAX1 PAX2 PAX5 PAX9

1.22e-08911147981748
Pubmed

Pax genes in development.

PAX1 PAX2 PAX5 PAX9

1.22e-08911147883790
Pubmed

Pax genes and their role in organogenesis.

PAX1 PAX2 PAX5 PAX9

1.22e-089111410197584
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-6 ERVK-7 ERVK-9 ERVK-10 ERVK-8 ERVK-19 ERVK-24

2.27e-0894111721542922
Pubmed

Pax3 Hypomorphs Reveal Hidden Pax7 Functional Genetic Compensation in Utero.

PAX1 PAX2 PAX5 PAX9

3.19e-0811111435645295
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-6 ERVK-9 ERVK-8 ERVK-19

4.77e-0812111414557543
Pubmed

Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.

ERVK-6 ERVK-10 ERVK-19

1.26e-07411137983737
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-7 ERVK-19

3.15e-075111312629516
Pubmed

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

ERVK-6 ERVK-9 ERVK-19

6.28e-076111315063128
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

1.01e-052111222737222
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

1.01e-052111216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

1.01e-052111215998580
Pubmed

Structural polymorphism of murine C4 and its linkage to H-2.

C4A C4B

1.01e-05211127373044
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

1.01e-052111219062096
Pubmed

The chemical structure of the C4d fragment of the human complement component C4.

C4A C4B

1.01e-05211123696167
Pubmed

Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.

C4A C4B

1.01e-05211121357031
Pubmed

Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.

C4A C4B

1.01e-052111216098595
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

1.01e-052111219933335
Pubmed

Aberrant Pax1 and Pax9 expression in Jarcho-Levin syndrome: report of two Caucasian siblings and literature review.

PAX1 PAX9

1.01e-052111212833407
Pubmed

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

C4A C4B

1.01e-05211122459207
Pubmed

Antigen-induced B cell apoptosis is independent of complement C4.

C4A C4B

1.01e-052111217645767
Pubmed

Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.

C4A C4B

1.01e-052111215787745
Pubmed

Anti-DNA autoreactivity in C4-deficient mice.

C4A C4B

1.01e-052111212207352
Pubmed

Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.

C4A C4B

1.01e-052111230026462
Pubmed

A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.

C4A C4B

1.01e-05211126559257
Pubmed

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

C4A C4B

1.01e-052111227758680
Pubmed

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

C4A C4B

1.01e-052111222387014
Pubmed

Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.

C4A C4B

1.01e-052111234299197
Pubmed

Assessment of complement C4 gene copy number using the paralog ratio test.

C4A C4B

1.01e-052111220506482
Pubmed

Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.

C4A C4B

1.01e-052111212480675
Pubmed

Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.

C4A C4B

1.01e-052111226800705
Pubmed

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.

C4A C4B

1.01e-052111223749435
Pubmed

Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.

C4A C4B

1.01e-052111223918728
Pubmed

Murine complement C4 is not required for experimental autoimmune encephalomyelitis.

C4A C4B

1.01e-052111215390104
Pubmed

Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.

C4A C4B

1.01e-05211123037333
Pubmed

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

C4A C4B

1.01e-052111211726230
Pubmed

Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

C4A C4B

1.01e-05211124216347
Pubmed

Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.

C4A C4B

1.01e-05211121699796
Pubmed

Sequence determination of the thiolester site of the fourth component of human complement.

C4A C4B

1.01e-05211126950384
Pubmed

Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.

C4A C4B

1.01e-05211122997024
Pubmed

Identification of two promoters for human D-amino acid oxidase gene: implication for the differential promoter regulation mediated by PAX5/PAX2.

PAX2 PAX5

1.01e-052111225500505
Pubmed

Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.

C4A C4B

1.01e-05211128660986
Pubmed

Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.

C4A C4B

1.01e-05211123624865
Pubmed

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

C4A C4B

1.01e-05211128428773
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

1.01e-05211129060628
Pubmed

Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.

C4A C4B

1.01e-052111221857912
Pubmed

Evolutionary conservation of gene structures of the Pax1/9 gene family.

PAX1 PAX9

1.01e-052111210899593
Pubmed

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.

C4A C4B

1.01e-052111224638111
Pubmed

Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.

C4A C4B

1.01e-05211126208559
Pubmed

The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.

C4A C4B

1.01e-05211124514997
Pubmed

Transcriptional repression of C4 complement by hepatitis C virus proteins.

C4A C4B

1.01e-052111221345967
Pubmed

The inheritance of susceptibility to the Gross leukemia virus in mice.

C4A C4B

1.01e-05211125919331
Pubmed

Colocalization of transcription and translation within cytoplasmic poxvirus factories coordinates viral expression and subjugates host functions.

G3BP1 CAPRIN1

1.01e-052111218005740
Pubmed

An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.

C4A C4B

1.01e-05211123167981
Pubmed

Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

ERVK-6 ERVK-19

1.01e-05211129460924
Pubmed

Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein (G3BP) and cytoplasmic activation/proliferation-associated protein (p137) individually or as a heterodimer.

G3BP1 CAPRIN1

1.01e-052111215471883
Pubmed

The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.

C4A C4B

1.01e-05211127545960
Pubmed

Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.

C4A C4B

1.01e-052111230041577
Pubmed

Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

C4A C4B

1.01e-05211122572548
Pubmed

The complement component C4 of mammals.

C4A C4B

1.01e-05211122302180
Pubmed

Complete cDNA sequence of the fourth component of murine complement.

C4A C4B

1.01e-05211123862104
Pubmed

The BS variant of C4 protects against age-related loss of white matter microstructural integrity.

C4A C4B

1.01e-052111234358307
Pubmed

Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.

C4A C4B

1.01e-052111218360261
Pubmed

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

C4A C4B

1.01e-052111222151770
Pubmed

C4d-positive chronic rejection: a frequent entity with a poor outcome.

C4A C4B

1.01e-052111218091514
Pubmed

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.

C4A C4B

1.01e-052111229080553
Pubmed

Schizophrenia risk from complex variation of complement component 4.

C4A C4B

1.01e-052111226814963
Pubmed

Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

C4A C4B

1.01e-05211126589636
Pubmed

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.

C4A C4B

1.01e-052111225339671
Pubmed

A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.

C4A C4B

1.01e-052111217728371
Pubmed

Structure and organization of the C4 genes.

C4A C4B

1.01e-05211126149580
Pubmed

Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.

C4A C4B

1.01e-05211126149581
Pubmed

The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.

C4A C4B

1.01e-052111212115608
Pubmed

Biochemistry and biology of anaphylatoxins.

C4A C4B

1.01e-05211123542363
Pubmed

C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.

C4A C4B

1.01e-05211122387317
Pubmed

Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.

C4A C4B

1.01e-05211128132550
Pubmed

Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.

C4A C4B

1.01e-05211122395880
Pubmed

Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.

C4A C4B

1.01e-052111226814708
Pubmed

cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).

C4A C4B

1.01e-05211126192448
Pubmed

Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the midbrain-hindbrain boundary.

PAX2 PAX5

1.01e-052111210662641
Pubmed

Complete primary structure of human C4a anaphylatoxin.

C4A C4B

1.01e-05211126167582
Pubmed

Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.

C4A C4B

1.01e-052111216908004
Pubmed

Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH.

G3BP1 CAPRIN1

1.01e-052111237161291
Pubmed

Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.

C4A C4B

1.01e-05211121438267
Pubmed

Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.

C4A C4B

1.01e-05211127365238
Pubmed

Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.

C4A C4B

1.01e-052111219150565
Pubmed

Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.

C4A C4B

1.01e-05211127391573
Pubmed

Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.

C4A C4B

1.01e-052111217506029
Pubmed

Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.

C4A C4B

1.01e-052111217971360
Pubmed

Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.

C4A C4B

1.01e-052111223715124
Pubmed

Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.

C4A C4B

1.01e-05211123464002
Pubmed

Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.

C4A C4B

1.01e-05211122993295
Pubmed

Clinical features of patients with homozygous complement C4A or C4B deficiency.

C4A C4B

1.01e-052111229928053
Pubmed

Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.

C4A C4B

1.01e-052111217971229
Pubmed

Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.

C4A C4B

1.01e-05211126881182
Pubmed

Identification of the site of sulfation of the fourth component of human complement.

C4A C4B

1.01e-05211123944109
Cytoband8p23.1

FAM90A14 FAM90A2P FAM90A17 FAM90A19 ERVK-8 FAM90A23 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10

3.48e-15154110128p23.1
CytobandEnsembl 112 genes in cytogenetic band chr8p23

FAM90A14 FAM90A2P FAM90A17 FAM90A19 FAM90A23 FAM90A7 FAM90A18 FAM90A9 FAM90A8 FAM90A16 FAM90A10

1.30e-1123411011chr8p23
Cytoband20p11.2

CRNKL1 PAX1

3.09e-0411110220p11.2
GeneFamilyPaired boxes

PAX1 PAX2 PAX5 PAX9

8.85e-099544675
GeneFamilyPRD class homeoboxes and pseudogenes

TPRX2 TPRX1 PAX2 PAX5

1.63e-0492544521
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

C4A C4B

3.11e-0495421234
GeneFamilyClustered protocadherins

PCDHGB7 PCDHGB6 PCDHGA12

9.22e-046454320
GeneFamilyPHD finger proteins|Lysine demethylases

KDM5C JMJD1C

2.32e-0324542485
GeneFamilyComplement system|Sushi domain containing

C4A C4B

5.17e-0336542492
GeneFamilyGlycosyltransferase family 6|Blood group antigens

C4A C4B

5.45e-0337542454
CoexpressionGSE7568_CTRL_VS_24H_TGFB_TREATED_MACROPHAGES_WITH_IL4_AND_DEXAMETHASONE_DN

ZMYND15 NRIP2 PDE2A ITGB7 TRIM7 SLC12A3 FAM171A2 PLEKHA7

5.84e-07200938M364
CoexpressionDESCARTES_FETAL_EYE_STROMAL_CELLS

VASN MATN4 TMEM200B IGSF10 SOCS1 ADAMTSL4

8.86e-0791936M40180
CoexpressionGSE17721_LPS_VS_POLYIC_1H_BMDC_DN

POLG TRIM7 METTL25B CELSR3 G3BP1 SOCS1 SNAPC2

7.14e-06199937M3800
ToppCell3'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GIMAP4 RPGRIP1 PNPLA2 PDE2A AFDN MAP4K2

2.37e-06183936a90ffd9c50caa65f537a2e441e37655e1b622327
ToppCell3'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GIMAP4 RPGRIP1 PNPLA2 PDE2A AFDN MAP4K2

2.37e-0618393613ad20ec140ef5b96fdace3369b5befc0f40bb76
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRIP2 VASN ITGA7 TMEM200B COL18A1 MCUR1

2.45e-0618493689ae8bf1a6c2d355d279d23a5e24a08d9ec2334e
ToppCellfacs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRIP2 VASN ITGA7 TMEM200B COL18A1 MCUR1

2.45e-0618493634c84ac9a32eaf96f45b79485119cad65905817d
ToppCelldistal-1-Hematologic-EREG+_Dendritic|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PDE2A OLFML2B SIK1 TTYH3 SLC12A3 HEATR3

3.84e-0619993615249f2f48b1e99d9d062835fd4c705a159e4abb
ToppCellE18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SHISA7 TRIM7 FAM78A SLC12A3 PAX5

2.29e-0516293559f6a9005c4f22f084c25ea36f3cacce5144a9ae
ToppCellfacs-Heart-RA-18m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPGRIP1 ITGB7 TRIM7 SLC12A3 PAX5

2.57e-05166935fc2cf67311c86fda75b35fcd4768b6f6f14c59d0
ToppCellfacs-Heart-RA-18m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPGRIP1 ITGB7 TRIM7 SLC12A3 PAX5

2.57e-0516693533a6876d06e26176135a73a77c19e634ec53f7ce
ToppCellfacs-Lung-Endomucin-3m-Mesenchymal-pericyte_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCDHGB7 ITGA7 MRM3 PAX1 ADAMTSL4

2.80e-051699352d23b4cee060f8adddc430c1c10d4e25205b4af6
ToppCellfacs-Lung-Endomucin-3m-Mesenchymal-Pericyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCDHGB7 ITGA7 MRM3 PAX1 ADAMTSL4

2.80e-05169935ecaf08e8e0b54d1c97a02bc1f65409fd43d68227
ToppCellfacs-Lung-Endomucin-3m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCDHGB7 ITGA7 MRM3 PAX1 ADAMTSL4

2.80e-05169935ad6af6609acf158cb79e45ee7ca9af332be3c40c
ToppCell10x5'-Lung-Lymphocytic_Invariant-Inducer-like-MAIT|Lung / Manually curated celltypes from each tissue

VASN NLRP6 FAM171A2 SOCS1 PAX2

3.31e-05175935f6663e5a9c87e27f3459a6481768b03aff7d0855
ToppCell10x5'-Lung-Lymphocytic_Invariant-Inducer-like|Lung / Manually curated celltypes from each tissue

VASN NLRP6 FAM171A2 SOCS1 PAX2

3.59e-05178935bb5dc22f6bcde1ce29598ae4e839e98a7caa07b6
ToppCellfacs-Heart-RV-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRIP2 CACNA2D1 ITGA7 MGAT3 BRINP2

3.79e-05180935a37cc885fe3f6cb9df69d43358064c83c18412e7
ToppCellfacs-Heart-RV-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRIP2 CACNA2D1 ITGA7 MGAT3 BRINP2

3.79e-0518093563a6d532b16b8b15c7c9102148d7297ee3afd641
ToppCellAT1-AT2_cells-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

EPHB2 FAM178B LAMB3 COL18A1 BRINP2

3.79e-051809353c7b2033821f9e34e2924bd8655f566edcbcc7d3
ToppCelldroplet-Spleen-SPLEEN-30m-Lymphocytic-T_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIMAP4 ITGA7 ITGB7 FAM78A SOCS1

3.79e-05180935978728c89497d26287f73974fb738ad9fde61415
ToppCellwk_08-11-Mesenchymal-Chondrocyte-ASPN+_chondrocyte|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

OLFML2B VASN MATN4 NRK PAX1

3.99e-051829350e52ba34e179d9bfaac7b49920b44c710b2b8dad
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NRIP2 OLFML2B VASN ITGA7 COL18A1

4.21e-05184935603faafb7b289a3c0242c84fc800c050c8a092ea
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response-SM_activated_stress_response_L.2.3.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NRIP2 OLFML2B VASN ITGA7 COL18A1

4.21e-05184935c350504bfe0ec31cd2fc2199de9b5fff151a8c5e
ToppCellE12.5-Endothelial-capillary_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

GIMAP4 PDE2A FAM78A GDPD5 COL18A1

4.32e-05185935e005d3c01a908157f780bbc1d53dd2ed814a39d2
ToppCell3'-GW_trimst-1-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GIMAP4 RPGRIP1 PDE2A GDPD5 MAP4K2

4.32e-05185935fb84fcf7f51f53489bcb3962fa9cb483e48257ed
ToppCellE12.5-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

GIMAP4 PDE2A FAM78A GDPD5 COL18A1

4.32e-051859350bccc424d0466f7f82baa00127c733640a2d50fb
ToppCell3'_v3-lymph-node_spleen-Myeloid_Monocytic-Nonclassical_monocytes|lymph-node_spleen / Manually curated celltypes from each tissue

ZMYND15 RPGRIP1 LILRB2 TBC1D8 UMODL1

4.43e-05186935d7da5edb2ee36f96cdd7e27eb9afcc1cbfd52bb6
ToppCell3'-GW_trimst-1-SmallIntestine-Endothelial-lymphatic_endothelial|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GIMAP4 RPGRIP1 PDE2A GDPD5 MAP4K2

4.43e-051869359d250d5ae7cf9129be05b41d70cb6c3a046c5f1e
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA2D1 OLFML2B ITGA7 COL18A1 PLEKHA7

4.54e-05187935218c9b4f28499389c43005d9626af2ac01066027
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA2D1 OLFML2B ITGA7 COL18A1 PLEKHA7

4.54e-05187935c7ac4b328efc2ebb72f71154661914193ff402ca
ToppCelldroplet-Lung-nan-18m-Mesenchymal-Airway_Smooth_Muscle|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA2D1 OLFML2B ITGA7 COL18A1 PLEKHA7

4.66e-0518893561f010c165826b434ca3d27553d4c9e13d2c0c51
ToppCelldroplet-Lung-nan-18m-Mesenchymal-bronchial_smooth_muscle_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA2D1 OLFML2B ITGA7 COL18A1 PLEKHA7

4.66e-051889357553ef7de3575af4cf34704b405b551c1af8eb83
ToppCell10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-muscle_stem_cell|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

CACNA2D1 OLFML2B VASN MATN4 NRK

4.66e-05188935de6f4889e0c5f39fbbaefd85526f645c6afa09d5
ToppCelldroplet-Heart-nan-18m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIMAP4 PNPLA2 PDE2A ERCC1 AFDN

4.66e-051889359dfa2e0b73640459cdf88277291e3ab9c33e0217
ToppCellfacs-Heart-RA-18m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIMAP4 PDE2A SIK1 FAM171A2 AFDN

4.78e-051899351be5067c1e45af7d09c1fd6955952cb9e031a3a0
ToppCell3'-GW_trimst-1.5-LargeIntestine-Hematopoietic-Myeloid-Macrophages|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZMYND15 LILRB2 TTYH3 TBC1D8 CELSR3

4.78e-05189935b8cbfc47f3f40b6fccd15899d58c87d07b0001aa
ToppCellIPF-Epithelial-Aberrant_Basaloid|Epithelial / Disease state, Lineage and Cell class

EPHB2 LAMB3 TTYH3 COL18A1 NRK

4.78e-051899354178be3292ff4a8a1d8098f638d4b8d15164d2c6
ToppCellfacs-Heart-RA-18m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIMAP4 PDE2A SIK1 FAM171A2 AFDN

4.78e-0518993530dc1725d43a60017fb12d706f1f85a33de4947e
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-basal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMB3 SIK1 CHADL JMJD1C SOCS1

5.02e-051919352f733d510a4862565a817f59829d8387d7ea26d9
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial-basal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMB3 SIK1 CHADL JMJD1C SOCS1

5.02e-051919358691eba35793e4e90f93d50c2145847ee51289f7
ToppCell5'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GIMAP4 RPGRIP1 PDE2A GDPD5 MAP4K2

5.15e-05192935fa0ef05a32c661bdd59b5a9b6f75fd647ee937f3
ToppCell5'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GIMAP4 RPGRIP1 PDE2A GDPD5 MAP4K2

5.15e-051929354e63d95f75fe6eb3f817e84528883e95093c5bbd
ToppCellmedial-2-Hematologic-IGSF21+_Dendritic|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

EPHB2 OLFML2B LILRB2 TTYH3 PLEKHA7

5.54e-05195935bb612979360b2322289545dda3d3c343d005ee6f
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-Pericytes|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NRIP2 OLFML2B VASN ITGA7 COL18A1

5.54e-051959359b3fa1d42ec5aa2911f27a99cd8b57714c6bd604
ToppCellfacs-Mammary_Gland-Mammary_Gland-18m-Epithelial-basal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMB3 SIK1 JMJD1C SOCS1 C4B

5.54e-05195935f41a68b7c2621594db8d8952e301eeadc96be26f
ToppCellmedial-Hematologic-IGSF21+_Dendritic-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

EPHB2 OLFML2B LILRB2 TTYH3 PLEKHA7

5.54e-05195935779130c2cfcbc603955b0c0332b855b22ab6e9e6
ToppCellmedial-Hematologic-IGSF21+_Dendritic|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

EPHB2 OLFML2B LILRB2 TTYH3 PLEKHA7

5.54e-05195935330b688d703d53cb7feb29373b5a6e6e529169ec
ToppCellBAL-Mild-Myeloid-MoAM-MoAM1|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

EPHB2 RTL5 OLFML2B LILRB2 TTYH3

5.68e-051969357c8aa5853d7096628e35af665097c0299c329753
ToppCellfacs-Skin-Telogen-3m-Epithelial-outer_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMB3 IGSF10 COL18A1 AFDN ADAMTSL4

5.68e-05196935c936014125b2ed5f796221b74acb77b8f8359875
ToppCellBAL-Mild-Myeloid-MoAM-MoAM1-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

EPHB2 RTL5 OLFML2B LILRB2 TTYH3

5.68e-05196935f60b220ed117bcc33e0f7bbf5b53d3b1422ebaca
ToppCelldroplet-Heart-HEART-1m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRIP2 OLFML2B VASN MATN4 ITGA7

5.68e-051969351eb14182ef26e6141f510d397b00bf8a12efda3e
ToppCellBAL-Mild-Myeloid-MoAM-MoAM1-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

EPHB2 RTL5 OLFML2B LILRB2 TTYH3

5.68e-05196935bcd274db4955ea76ca26267a272c7d1929db24f4
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRIP2 VASN ITGA7 TMEM200B COL18A1

5.68e-05196935184104cbea0461dd2757668ab9755948ac7b585a
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRIP2 VASN ITGA7 TMEM200B COL18A1

5.68e-05196935bebb20dc210576101c317011e3afb59798f5d255
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRIP2 VASN ITGA7 TMEM200B COL18A1

5.68e-051969358114e98923096c54b6834f21550c3061bab6773d
ToppCellBAL-Mild-Myeloid-MoAM-MoAM1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

EPHB2 RTL5 OLFML2B LILRB2 TTYH3

5.68e-0519693580b9139d91dda4de69830d2d443859e047ab5503
ToppCellMild_COVID-19-Myeloid-MoAM1|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

EPHB2 RTL5 OLFML2B LILRB2 TTYH3

5.68e-05196935ea3fbe81b4ecb6ccc8031f6d99da93c9f9f8c1aa
ToppCellParenchymal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NRIP2 VASN ITGA7 COL18A1 PAX1

5.82e-051979353f078be0b0f5e16edfb6d517beb20ac6178767f0
ToppCellCOVID-19_Severe-Non-classical_Monocyte|World / disease group, cell group and cell class

ZMYND15 LILRB2 TTYH3 TBC1D8 UMODL1

5.82e-0519793560fee75b12451206bb2c07b61651a73c59ec6ade
ToppCellBAL-Mild-Myeloid-MoAM|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

EPHB2 RTL5 OLFML2B LILRB2 TTYH3

5.82e-051979350f40dd3530eb8d02e79b32f942efe3b65b8f6ee6
ToppCellBAL-Mild-Myeloid-MoAM|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

EPHB2 RTL5 OLFML2B LILRB2 TTYH3

5.82e-05197935a6aa5991d566c28440f7e24a30933e69669064f2
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NRIP2 OLFML2B VASN ITGA7 COL18A1

5.96e-051989353222d064b6ecab0caa450a59fc1dc79e26fc6fd5
ToppCell3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GIMAP4 PDE2A FAM78A GDPD5 MAP4K2

5.96e-0519893596d46e73f968391000ecd14c787efb93c79f96ec
ToppCellCOVID-19_Moderate-Non-classical_Monocyte|World / disease group, cell group and cell class

LILRB2 OAS3 TTYH3 TBC1D8 ADAMTSL4

5.96e-051989358449934e20bb2a34079fb642cae0d4647b9efe51
ToppCellSevere_COVID-19|World / Disease group,lineage and cell class （2021.01.30）

GIMAP4 OLFML2B LILRB2 OAS3 SOCS1

5.96e-0519893509fd456077bb3a657ad3b10c6cfe799b7266456a
ToppCellHealthy_donor-Non-classical_Monocyte|World / disease group, cell group and cell class (v2)

ZMYND15 LILRB2 TTYH3 TBC1D8 ADAMTSL4

5.96e-051989358a97c8b2a43e6d1e669ce18752841e2006744bd9
ToppCellBAL-Severe|BAL / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GIMAP4 OLFML2B LILRB2 OAS3 SOCS1

5.96e-05198935454aee3f4fe6d0beeccc55200b4495f4f9b44feb
ToppCellParenchymal-10x5prime-Stromal-Pericyte-Muscle_pericyte_systemic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NRIP2 MATN4 ITGA7 COL18A1 C4B

5.96e-051989350dc5806714fb3d3983e9d19fa7a108e93a8090ed
ToppCellBAL-Severe|BAL / Location, Disease Group, Cell group, Cell class (2021.03.09)

GIMAP4 OLFML2B LILRB2 OAS3 SOCS1

5.96e-05198935687f69c16343227854c882b4a0f3930ce534a3d2
ToppCelldroplet-Limb_Muscle-nan-3m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA2D1 OLFML2B VASN MATN4 IGSF10

6.10e-05199935edd5300da1a3b758210ff8f949e9d1988b8bc7e2
ToppCellParenchymal-10x5prime-Stromal-Myofibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NRIP2 OLFML2B VASN ITGA7 COL18A1

6.10e-0519993520f760d92c351a1dac4cc0a424c443ea03a179fe
ToppCellBiopsy_Control_(H.)-Mesenchymal-Mesothelial_cells|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

CACNA2D1 NRK BRINP2 C4A C4B

6.10e-05199935ca970114b5aef4518ce580897a62ac88688b2671
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KDM5C POLG TPGS1 ITGB7 SOCS1

6.10e-0519993526bb93347e6722abd174dfa62cab692ce2b7eb23
ToppCellPBMC-Control-cDC_0|Control / Compartment, Disease Groups and Clusters

GIMAP4 LILRB2 TTYH3 TRIM7 ADAMTSL4

6.10e-05199935ebf03979ef56e978d72db475bb635b43b9cbe402
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

OLFML2B LILRB2 SIK1 TTYH3 ADAMTSL4

6.10e-05199935667b8b47a5b388506e3177b46747267fad8024f6
ToppCellLPS_IL1RA-Hematopoietic_Myeloid-Dendritic_cells-pDC|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

FAM178B SIK1 ITGB7 TBC1D8 SOCS1

6.10e-05199935f197ab861767ee06aa47b86c537fb3d8c2b2bc3e
ToppCelldistal-3-mesenchymal-Airway_Smooth_Muscle|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NRIP2 OLFML2B VASN ITGA7 COL18A1

6.25e-052009354072cfb3047954f507289587b4bfaf1526936992
ToppCelldistal-mesenchymal-Airway_Smooth_Muscle-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NRIP2 OLFML2B VASN ITGA7 COL18A1

6.25e-05200935bc969a956f62570419a5faaf0ab0fd17b343c5ca
ToppCelldistal-Hematologic-EREG+_Dendritic-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PDE2A SIK1 TTYH3 SLC12A3 HEATR3

6.25e-052009357809c74a2e52768854b66a135522138281bc4449
ToppCellMonocytes-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

RPGRIP1 LILRB2 ITGB7

1.47e-0449933bf67f5dee042fd680c661db637fde715e48b14c5
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE2A OLFML2B CFAP65 MAP4K2

1.74e-04133934f6e9a1301a3379847b215303a9b0c028841e2cc0
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE2A OLFML2B CFAP65 MAP4K2

1.74e-04133934292ecfcadbaf15e0d34a3ab9bf511ab1065888bd
ToppCellTCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma-5|TCGA-Adrenal / Sample_Type by Project: Shred V9

CFAP65 GDPD5 CELSR3 GDPGP1

1.79e-04134934d4b175257c47916ed90cdb5c555c2b26530ce8d5
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SIK1 CFAP65 AFDN PAX5

1.84e-041359347743a01dc9c4542e910e7c0fe046004692a680bf
ToppCell10x3'2.3-week_12-13-Myeloid_DC-DC-DC_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SLC12A3 PAX2 PAX9 CCDC188

2.00e-04138934096c0c8ed396a27d29cca94e2e15099b64129c57
ToppCelldroplet-Lung-nan-3m-Myeloid-intermediate_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SIK1 OAS3 TBC1D8 SLC12A3

2.29e-041439344d11d53330a9197275a8851e1bbf55a113715a09
ToppCelldroplet-Lung-nan-3m-Myeloid-Intermediate_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SIK1 OAS3 TBC1D8 SLC12A3

2.29e-041439348b9f4d87d5faac7752c83e1992491fc5550600f8
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb|Cerebellum / BrainAtlas - Mouse McCarroll V32

WEE1 LAMB3 ITGB7 PAX2

2.68e-041499346e9ca280a599d96f8956ef26f2a46b9484de5488
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ITGA7 MGAT3 CELSR3

2.69e-046093328415d543aaccc74d19e1bb92b7e6fa94f97f8f2
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ITGA7 MGAT3 CELSR3

2.69e-046093371eba0fbef11cfc2b1c525d5f051530750e4fce9
ToppCellSubstantia_nigra-Macroglia-POLYDENDROCYTE|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

PCDHGB7 MATN4 CHADL ITGB7

2.75e-0415093470ac8ae4b1683fb17278a8e4606f2fa0b94988c0
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Krt80_Sla|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

OLFML2B ITGA7 NLRP6 GDPD5

2.82e-04151934f50c5ae9dae507df750df25e151b58685fec70ce
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-Like-AT2_Progenitor|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZMYND15 MATN4 CHADL CCNA2

2.82e-04151934c06a54afe918b14f885d6a85fbcf81e80f33afae
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRIP2 MATN4 TRIM7 BRINP2

2.89e-04152934d5ba87b5d34e52cef8475befafea962d70fa8a1d
ToppCelldroplet-Liver-LIVER_HEPATOCYTES|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRIP2 MATN4 TRIM7 BRINP2

2.89e-04152934d88d68a788a3256671ebbc06e104833f1f58f07d
ToppCell18-Airway-Epithelial-Goblet-like_secretory|Airway / Age, Tissue, Lineage and Cell class

GDPD5 DDX23 PAX1 PAX9

2.97e-0415393414a60220e169ce642771636de982a7b02e5b2608
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FAM178B SRCAP CCNA2 MDC1

2.97e-04153934991782d111d66e25b40319d4e6dea40f2c2c0805
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

WEE1 SRCAP ARSF UMODL1

3.19e-04156934bb505f639dbcad2b788db62d6084c2cb4e884bec
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-B_cells-CLP|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FAM178B ITGB7 UMODL1 HEATR3

3.27e-04157934d12f343454202da86a06d0369f8ffe5662cd091b
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-2|TCGA-Colorectal / Sample_Type by Project: Shred V9

ZMYND15 LILRB2 TRIM7 PAX9

3.27e-0415793467641089eeb1a502e01fb6ea35c3d19e21a5789e
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NRIP2 GIMAP4 ITGB7 CCNA2

3.43e-04159934a5509f0604ef0caef5ed1af83dd89c86686c73cc
ToppCellmild-Myeloid-CD14_Monocytes_3|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

EPHB2 GIMAP4 TTYH3 ADAMTSL4

3.52e-04160934a83568cd8a0b05642bacd43a8ec443e5ce314c4d
ToppCellClub_cells-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

WEE1 VASN KLK14 SIK1

3.60e-04161934342f5c61d37df61b35c18f5d258043a8f5cef629
Diseasesystemic lupus erythematosus (implicated_via_orthology)

TRAF3IP2 C4A C4B

2.81e-0443873DOID:9074 (implicated_via_orthology)
Diseaseheart rate

CACNA2D1 PNPLA2 UMODL1 ANTKMT HEATR3

5.48e-04225875EFO_0004326
Diseasechildhood trauma measurement, alcohol consumption measurement

PCDHGB7 PCDHGB6 PCDHGA12

1.22e-0371873EFO_0007878, EFO_0007979
DiseaseRenal glomerular disease

SLC12A3 PAX2

2.09e-0323872C0268731
DiseaseGlomerulopathy Assessment

SLC12A3 PAX2

2.09e-0323872C4521256
Diseasefactor VIII measurement, von Willebrand factor measurement

GIMAP4 MGAT3

2.88e-0327872EFO_0004629, EFO_0004630

Protein segments in the cluster

PeptideGeneStartEntry
PQGLPQRLNLTGAVR

UMODL1

976

Q5DID0
LQPQQQPRTIERRDL

AFDN

1481

P55196
NRRVIQNLAVPAGLP

ARSF

101

P54793
IPAGALRLQIAQLRP

ADAMTSL4

506

Q6UY14
ARTPGTLQRQVRIPQ

ADAMTSL4

636

Q6UY14
QPVTPLQLFEGRRNR

C4B

1436

P0C0L5
PVAQADPLVRRQRVQ

CAPRIN1

346

Q14444
GPDPLVQQRNRENLL

CDK5R2

91

Q13319
SQPAQLPGRRQLGLV

DNAJC1

6

Q96KC8
RAQTLQKQRRAPVGP

FAM90A10

16

A6NDY2
IQRVRRQNLLSVVPP

ASXL2

1071

Q76L83
LLQPGFRRVPLRLQV

ANTKMT

41

Q9BQD7
SRVLRQPRPALAQQA

GMCL1

6

Q96IK5
IIPRGRTQLFALNPR

PCDHGA12

66

O60330
RAQTLQKQRRAPVGP

FAM90A7

16

A6NKC0
RILVQARPGQDIRPI

GPHN

446

Q9NQX3
AQRRRAGPRQVLFPL

PCDHGB6

6

Q9Y5F9
AQRRRAGPRQVLFPL

PCDHGB7

6

Q9Y5F8
VFVNGRPLPDVVRQR

PAX5

26

Q02548
PGLFEQRRLQQQVPL

MAP4K2

556

Q12851
RAQTLQKQRRAPVGP

FAM90A23

16

A8MXZ1
QVVRILERQGPRAAP

FHIP1B

46

Q8N612
LRFLQRNGLLNRPNP

PNPLA2

246

Q96AD5
VNGRPLPNAIRLRIV

PAX9

16

P55771
QGARPRALNVPRVGL

MATN4

481

O95460
QGALRLQLRLNPPAQ

MAP1S

186

Q66K74
TQRLPGRQRLLFLPV

MCUR1

11

Q96AQ8
PRVQGETQPQRLLLA

MDC1

151

Q14676
PREVPRRVINAINVN

MGAT3

201

Q09327
LQLQQPARIGRAVRP

KLK14

131

Q9P0G3
RAQTLQKQRRAPVGP

FAM90A1

16

Q86YD7
AVQPSRGLIQPNERL

CFAP65

926

Q6ZU64
LNQLQRPPQETGERL

JMJD1C

1001

Q15652
RQRGNPVLKFVRNVP

ERCC1

106

P07992
RAQTLQKQRRAPVGP

FAM90A14

16

P0C7W9
IQSVEGQPLARRPRA

EPHB2

981

P29323
GRDPNDVRPIQARLL

PNN

31

Q9H307
KQQRLLNGPPRGIRA

PDZD7

46

Q9H5P4
VALRRVQVLQQRGPR

PDE2A

186

O00408
VQVLQQRGPREAPRA

PDE2A

191

O00408
AAPSQQLQRPDVRLR

COL18A1

246

P39060
ERDLRQLPGRQPQAG

LILRB2

261

Q8N423
RQRPLVRKVAPGFQQ

GDPD5

396

Q8WTR4
AQLNVERGVQRRPPQ

GDPGP1

96

Q6ZNW5
VQRGLQRVGLDPQLP

METTL25B

376

Q96FB5
RAQTLQKQRRAPVGP

FAM90A17

16

P0DV74
PIQRQAIPIGLQNRD

DDX23

416

Q9BUQ8
QRARPAGRPAAQELL

POM121L12

156

Q8N7R1
RAQTLQKQRRAPVGP

FAM90A16

16

P0DV73
RREVLQNQLGIRPPT

HUWE1

2981

Q7Z6Z7
RAQTLQKQRRAPVGP

FAM90A19

16

P0DV76
VFVNGRPLPDVVRQR

PAX2

26

Q02962
QRVRVTLRPGEPQQL

ITGB7

126

P26010
QPLVQFQRRAARLPV

FAM171A2

151

A8MVW0
RAQTLQKQRRAPVGP

FAM90A8

16

A6NJQ4
NGRPLPNAIRLRIVE

PAX1

111

P15863
VDGNVVRLRLRQRQP

CCDC105

456

Q8IYK2
EQVRRNRAANPPVNI

ERVK-10

376

P87889
EQVRRNRAANPPVNI

ERVK-19

376

Q9YNA8
EQVRRNRAANPPVNI

ERVK-24

376

P63145
EQVRRNRAANPPVNI

ERVK-6

376

Q7LDI9
EQVRRNRAANPPVNI

ERVK-7

376

P63130
EQVRRNRAANPPVNI

ERVK-8

376

P62685
EQVRRNRAANPPVNI

ERVK-9

376

P63126
EQVRRNRAANPPVNI

HERVK_113

376

P62684
QARGQRSVLQVPLPV

CRNKL1

111

Q9BZJ0
VQQRPALPGLARRDA

HEATR3

66

Q7Z4Q2
QVIAAPPVILEQRRQ

IGSF10

1836

Q6WRI0
IPTINLRKRRPNIQN

CACNA2D1

536

P54289
QIPPQRPQRDQRVRE

G3BP1

291

Q13283
QRVREQRINIPPQRG

G3BP1

301

Q13283
TQPLGNRAPLQLLRR

CCDC188

216

H7C350
NLRVNFTRLAPVPQR

LAMB3

216

Q13751
LQTPRLRRQAPGQGL

ITGA7

641

Q13683
RAQTLQKQRRAPVGP

FAM90A20P

16

A6NIJ5
LQGPGQLRRLRLQGN

CHADL

296

Q6NUI6
LAQQQRPKTRRVAPL

CCNA2

61

P20248
PAQFQAERRGARLPQ

CELSR3

2421

Q9NYQ7
RAQTLQKQRRAPVGP

FAM90A5P

16

A8MXJ8
RVQTVRVQLPDPQRG

NLRP6

786

P59044
QPVTPLQLFEGRRNR

C4A

1436

P0C0L4
RAQTLQKQRRAPVGP

FAM90A24P

16

P0C7X0
GQFLQRQLKRPRPVI

OAS3

281

Q9Y6K5
PRSVIQRRLVEGNPN

NRIP2

116

Q9BQI9
RRRPFRQIQVLEPLN

NRK

1246

Q7Z2Y5
RRNQNRVPLLEGLPG

RTL5

506

Q5HYW3
GALGLQLRPRVRPQR

POLG

41

A0A3B3IS91
PRRAQPRVQVGHRQL

RPGRIP1

136

Q96KN7
RPRPGNILLQLRQGQ

TRPC4AP

31

Q8TEL6
RLRQGVLRAQALRPP

TMEM200B

146

Q69YZ2
SIEVNPNRPLGQRAR

FAM78A

216

Q5JUQ0
GQRARLREPIAQDQP

FAM78A

226

Q5JUQ0
PGRQEPRNSQLRIVL

GIMAP4

21

Q9NUV9
RPARFVVRPLLQVVQ

MRM3

6

Q9HC36
PGAGLAPQLRRQDQR

FAM178B

6

Q8IXR5
RAQTLQKQRRAPVGP

FAM90A12P

16

A8MX19
RAQTLQKQRRAPVGP

FAM90A9

16

A6NNJ1
RAQTLQKQRRAPVGP

FAM90A13P

16

P0C7W8
RAQTLQKQRRAPVGP

FAM90A26

16

D6RGX4
GKRDQAIRRNPNVPV

PLEKHA7

151

Q6IQ23
GPNLPTLRQRVLEGR

SIK1B

226

A0A0B4J2F2
GPNLPTLRQRVLEGR

SIK1

226

P57059
LARRPPFQRQGTLEQ

SHISA7

501

A6NL88
AQVRQLAVGQPRPLQ

SRCAP

1221

Q6ZRS2
QRPLQRQVHLRGRPA

OLFML2B

276

Q68BL8
VGRENLARIPLNPVL

SOCS1

186

O15524
RAQTLQKQRRAPVGP

FAM90A15P

16

P0C7V4
EQVRRNRAANPPVNI

ERVK-9

376

P63128
PEFIRNIRLLGRRPN

BRINP2

116

Q9C0B6
QPQDVLGIRQLERPL

TRAF3IP2

211

O43734
IRQGRLPRIPQVLSQ

WEE1

526

P30291
ARERRLQQQPQRVPG

TPRX1

21

Q8N7U7
RPSQLRPNRQLAAVA

TRIM7

86

Q9C029
NARVAPFRILLQVPG

TBC1D8

56

O95759
RAQTLQKQRRAPVGP

FAM90A2P

16

Q658T7
LRPPVILIRGNQENV

SLC12A3

1001

P55017
NQLERVPPVIRGLRG

VASN

226

Q6EMK4
EPPGQLLLQQQRLGR

TPGS1

86

Q6ZTW0
RQLAGRPEPLRAVQR

TTYH3

156

Q9C0H2
RQLEAQIRRLPQDPA

ZMYND15

41

Q9H091
LPEPNLNSARRIRNI

ZNF106

746

Q9H2Y7
QLVRLLQARQGQPEP

SNAPC2

31

Q13487
ARERRLQQQPQRVPG

TPRX2

76

P0DV77
RAQTLQKQRRAPVGP

FAM90A18

16

P0DV75
QLLQAGQPPDLERIR

KDM5C

1421

P41229