Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionIMP dehydrogenase activity

IMPDH1 IMPDH2

3.17e-0521132GO:0003938
GeneOntologyMolecularFunctiondioxygenase activity

KDM5D JMJD1C JMJD7 TET1 FTO

2.37e-04981135GO:0051213
GeneOntologyMolecularFunctiontransaminase activity

PHYKPL OAT KYAT1

4.17e-04261133GO:0008483
GeneOntologyMolecularFunctionATP-activated inward rectifier potassium channel activity

KCNJ1 KCNJ10

4.69e-0461132GO:0015272
GeneOntologyMolecularFunction2-oxoglutarate-dependent dioxygenase activity

KDM5D JMJD7 TET1 FTO

5.05e-04651134GO:0016706
GeneOntologyMolecularFunctiontransferase activity, transferring nitrogenous groups

PHYKPL OAT KYAT1

5.21e-04281133GO:0016769
GeneOntologyMolecularFunctionextracellular matrix binding

ZAN TGFBI NTN4 NID1

7.84e-04731134GO:0050840
GeneOntologyMolecularFunctionlaminin-1 binding

NTN4 NID1

8.69e-0481132GO:0043237
GeneOntologyBiologicalProcessin utero embryonic development

HIF1A RPGRIP1L NCKAP1 SPEG CUBN CR1 BIRC6 GLI3 TTLL4 SUV39H1 TET1 MFN2 C6

1.93e-0559611113GO:0001701
GeneOntologyBiologicalProcessembryo development

HIF1A RPGRIP1L DEAF1 NCKAP1 SPEG LAMA2 TDG CUBN CR1 BIRC6 HOXA2 BRCA1 NFE2L2 GLI3 TTLL4 SUV39H1 TET1 MFN2 C6 CPLANE1 NDRG4

2.37e-05143711121GO:0009790
GeneOntologyBiologicalProcesschordate embryonic development

HIF1A RPGRIP1L DEAF1 NCKAP1 SPEG CUBN CR1 BIRC6 HOXA2 BRCA1 GLI3 TTLL4 SUV39H1 TET1 MFN2 C6

2.74e-0590611116GO:0043009
GeneOntologyBiologicalProcessembryo development ending in birth or egg hatching

HIF1A RPGRIP1L DEAF1 NCKAP1 SPEG CUBN CR1 BIRC6 HOXA2 BRCA1 GLI3 TTLL4 SUV39H1 TET1 MFN2 C6

3.71e-0592911116GO:0009792
GeneOntologyBiologicalProcesspositive regulation of activation of membrane attack complex

CR1 C6

8.58e-0531112GO:0001970
DomainEGF_1

ZAN LAMA2 CUBN ADGRE2 SSPOP CRB1 NTN4 EYS FAT2 NID1 C6

4.22e-0725511311PS00022
DomainEGF-like_CS

ZAN LAMA2 CUBN ADGRE2 CRB1 NTN4 EYS FAT2 NID1 C6

4.20e-0626111310IPR013032
DomainEGF_2

ZAN LAMA2 CUBN ADGRE2 SSPOP CRB1 EYS FAT2 NID1 C6

4.80e-0626511310PS01186
DomainEGF_3

ZAN CUBN ADGRE2 SSPOP CRB1 EYS FAT2 NID1 C6

1.30e-052351139PS50026
DomainEGF-like_dom

ZAN LAMA2 CUBN ADGRE2 CRB1 EYS FAT2 NID1 C6

2.06e-052491139IPR000742
DomainIMP_DH

IMPDH1 IMPDH2

3.63e-0521132IPR005990
DomainLAM_G_DOMAIN

LAMA2 CRB1 EYS FAT2

8.00e-05381134PS50025
DomainEGF

ZAN LAMA2 CUBN ADGRE2 CRB1 EYS FAT2 NID1

9.17e-052351138SM00181
DomainEGF_CA

CUBN ADGRE2 CRB1 EYS FAT2 NID1

9.81e-051221136SM00179
DomainLaminin_G_2

LAMA2 CRB1 EYS FAT2

9.81e-05401134PF02210
DomainEGF-like_Ca-bd_dom

CUBN ADGRE2 CRB1 EYS FAT2 NID1

1.07e-041241136IPR001881
DomainEGF

ZAN CUBN CRB1 EYS FAT2 NID1

1.17e-041261136PF00008
DomainLamG

LAMA2 CRB1 EYS FAT2

1.43e-04441134SM00282
DomainNdr

NDRG1 NDRG4

2.16e-0441132PF03096
DomainIMPDH

IMPDH1 IMPDH2

2.16e-0441132PF00478
DomainNDRG

NDRG1 NDRG4

2.16e-0441132IPR004142
DomainIMP_DH_GMPRt

IMPDH1 IMPDH2

2.16e-0441132IPR001093
DomainIMP_DH_GMP_RED

IMPDH1 IMPDH2

2.16e-0441132PS00487
DomainIMP_DH/GMP_Rdtase_CS

IMPDH1 IMPDH2

2.16e-0441132IPR015875
DomainFA58C

SSPOP F8 CPXM1

2.65e-04211133SM00231
DomainFA58C_3

SSPOP F8 CPXM1

2.65e-04211133PS50022
DomainFA58C_1

SSPOP F8 CPXM1

2.65e-04211133PS01285
DomainFA58C_2

SSPOP F8 CPXM1

2.65e-04211133PS01286
DomainGalactose-bd-like

LAMA2 SSPOP F8 NTN4 CPXM1

2.65e-04941135IPR008979
DomainEGF_Ca-bd_CS

CUBN ADGRE2 CRB1 EYS NID1

3.07e-04971135IPR018097
DomainEGF_CA

CUBN ADGRE2 CRB1 EYS NID1

3.37e-04991135PS01187
DomainASX_HYDROXYL

CUBN ADGRE2 CRB1 EYS NID1

3.54e-041001135PS00010
DomainAminotrans_3

PHYKPL OAT

3.59e-0451132IPR005814
DomainAminotran_3

PHYKPL OAT

3.59e-0451132PF00202
DomainAA_TRANSFER_CLASS_3

PHYKPL OAT

3.59e-0451132PS00600
DomainGrowth_fac_rcpt_

CUBN ADGRE2 CRB1 NTN4 EYS NID1

3.73e-041561136IPR009030
DomainF5_F8_type_C

SSPOP F8 CPXM1

3.98e-04241133PF00754
DomainFA58C

SSPOP F8 CPXM1

3.98e-04241133IPR000421
DomainLaminin_G

LAMA2 CRB1 EYS FAT2

4.19e-04581134IPR001791
DomainEGF-type_Asp/Asn_hydroxyl_site

CUBN ADGRE2 CRB1 EYS NID1

4.62e-041061135IPR000152
DomainJMJC

KDM5D JMJD1C JMJD7

9.41e-04321133PS51184
DomainJmjC_dom

KDM5D JMJD1C JMJD7

9.41e-04321133IPR003347
Domain-

DCAF8L2 GNB1L COPB2 NUP43 SEMA5A BIRC6 MET TLE2

9.49e-0433311382.130.10.10
DomainWD40/YVTN_repeat-like_dom

DCAF8L2 GNB1L COPB2 NUP43 SEMA5A BIRC6 MET TLE2

9.86e-043351138IPR015943
Domain-

LAMA2 SSPOP F8 CPXM1

1.00e-037311342.60.120.260
DomainJmjC

KDM5D JMJD1C JMJD7

1.03e-03331133SM00558
Domain-

PHYKPL OAT KYAT1

1.23e-033511333.90.1150.10
DomainPyrdxlP-dep_Trfase_major_sub2

PHYKPL OAT KYAT1

1.33e-03361133IPR015422
Domain-

PHYKPL OAT KYAT1

1.68e-033911333.40.640.10
DomainLDLR_class-A_CS

LDLRAD3 SSPOP C6

1.81e-03401133IPR023415
DomainLaminin_G_1

LAMA2 EYS

1.93e-03111132PF00054
DomainPyrdxlP-dep_Trfase

PHYKPL OAT KYAT1

1.94e-03411133IPR015424
DomainPyrdxlP-dep_Trfase_major_sub1

PHYKPL OAT KYAT1

1.94e-03411133IPR015421
DomainEGF_dom

CUBN NID1

2.30e-03121132IPR024731
DomainC8

ZAN SSPOP

2.30e-03121132PF08742
DomainEGF_3

CUBN NID1

2.30e-03121132PF12947
DomainTIL

ZAN SSPOP

2.30e-03121132PF01826
DomainLdl_recept_a

LDLRAD3 SSPOP C6

2.54e-03451133PF00057
Domain-

LAMA2 CRB1 EYS FAT2

2.65e-039511342.60.120.200
DomainUnchr_dom_Cys-rich

ZAN SSPOP

2.71e-03131132IPR014853
DomainC8

ZAN SSPOP

2.71e-03131132SM00832
DomainLDLRA_1

LDLRAD3 SSPOP C6

3.06e-03481133PS01209
DomainTIL_dom

ZAN SSPOP

3.15e-03141132IPR002919
DomainLDrepeatLR_classA_rpt

LDLRAD3 SSPOP C6

3.24e-03491133IPR002172
DomainLDLa

LDLRAD3 SSPOP C6

3.24e-03491133SM00192
DomainLDLRA_2

LDLRAD3 SSPOP C6

3.24e-03491133PS50068
DomainSushi

CSMD2 CR1 C6

3.84e-03521133PF00084
DomainCBS

IMPDH1 IMPDH2

4.12e-03161132SM00116
DomainVWF_type-D

ZAN SSPOP

4.12e-03161132IPR001846
DomainLaminin_N

LAMA2 NTN4

4.12e-03161132IPR008211
DomainVWFD

ZAN SSPOP

4.12e-03161132PS51233
DomainIRK

KCNJ1 KCNJ10

4.12e-03161132PF01007
DomainLamNT

LAMA2 NTN4

4.12e-03161132SM00136
DomainVWD

ZAN SSPOP

4.12e-03161132SM00216
DomainK_chnl_inward-rec_Kir_cyto

KCNJ1 KCNJ10

4.12e-03161132IPR013518
DomainLAMININ_NTER

LAMA2 NTN4

4.12e-03161132PS51117
DomainLaminin_N

LAMA2 NTN4

4.12e-03161132PF00055
Domain-

KCNJ1 KCNJ10

4.12e-031611322.60.40.1400
DomainK_chnl_inward-rec_Kir

KCNJ1 KCNJ10

4.12e-03161132IPR016449
DomainVWD

ZAN SSPOP

4.12e-03161132PF00094
DomainCCP

CSMD2 CR1 C6

4.27e-03541133SM00032
DomainEMI

SSPOP TGFBI

4.65e-03171132PS51041
DomainSUSHI

CSMD2 CR1 C6

4.74e-03561133PS50923
DomainSushi_SCR_CCP_dom

CSMD2 CR1 C6

4.98e-03571133IPR000436
DomainVWC_out

ZAN SSPOP

5.80e-03191132SM00215
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

HIF1A TES DEAF1 FOXJ3 BIRC6 MET NDRG1 BRCA1 GLI3 MKI67 NDRG4 NR1D2

3.90e-067091141222988430
Pubmed

Expression of IMPDH mRNA after mycophenolate administration in male volunteers.

IMPDH1 IMPDH2

1.07e-052114225105143
Pubmed

Triptolide, a Chinese herbal extract, enhances drug sensitivity of resistant myeloid leukemia cell lines through downregulation of HIF-1α and Nrf2.

HIF1A NFE2L2

1.07e-052114223930677
Pubmed

FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids.

BRIP1 BRCA1

1.07e-052114228911102
Pubmed

Hydrogen sulphide induces HIF-1α and Nrf2 in THP-1 macrophages.

HIF1A NFE2L2

1.07e-052114225795259
Pubmed

Association of fat mass and obesity-associated and retinitis pigmentosa guanosine triphosphatase (GTPase) regulator-interacting protein-1 like polymorphisms with body mass index in Chinese women.

RPGRIP1L FTO

1.07e-052114229657248
Pubmed

Time- and oxygen-dependent expression and regulation of NDRG1 in human brain cancer cells.

HIF1A NDRG1

1.07e-052114228498432
Pubmed

CRB1rd8 mutation influences the age-related macular degeneration phenotype of NRF2 knockout mice and favors choroidal neovascularization.

CRB1 NFE2L2

1.07e-052114231918066
Pubmed

Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice.

IMPDH1 IMPDH2

1.07e-052114212944494
Pubmed

Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1.

BRIP1 BRCA1

1.07e-052114233619228
Pubmed

HIF-1α and Nrf2 regulates hypoxia induced overexpression of DDAH1 through promoter activation in prostate cancer.

HIF1A NFE2L2

1.07e-052114235644470
Pubmed

Breast cancer susceptibility gene 1 regulates oxidative damage via nuclear factor erythroid 2-related factor 2 in oral cancer cells.

BRCA1 NFE2L2

1.07e-052114235512617
Pubmed

Prognostic significance of Ki67 proliferation index, HIF1 alpha index and microvascular density in patients with non-small cell lung cancer brain metastases.

HIF1A MKI67

1.07e-052114224577133
Pubmed

Cloning and sequence analysis of the human and Chinese hamster inosine-5'-monophosphate dehydrogenase cDNAs.

IMPDH1 IMPDH2

1.07e-05211422902093
Pubmed

HIF1α/TET1 Pathway Mediates Hypoxia-Induced Adipocytokine Promoter Hypomethylation in Human Adipocytes.

HIF1A TET1

1.07e-052114231935962
Pubmed

NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α.

HIF1A NFE2L2

1.07e-052114221278237
Pubmed

Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo.

IMPDH1 IMPDH2

1.07e-052114214766016
Pubmed

HIF-1α up-regulates NDRG1 expression through binding to NDRG1 promoter, leading to proliferation of lung cancer A549 cells.

HIF1A NDRG1

1.07e-052114223526365
Pubmed

Characterization of the human inosine-5'-monophosphate dehydrogenase type II gene.

IMPDH1 IMPDH2

1.07e-05211427896827
Pubmed

m6A methylation promotes white-to-beige fat transition by facilitating Hif1a translation.

HIF1A FTO

1.07e-052114234569703
Pubmed

Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation.

NFE2L2 TET1

1.07e-052114224743738
Pubmed

NRF2 facilitates breast cancer cell growth via HIF1ɑ-mediated metabolic reprogramming.

HIF1A NFE2L2

1.07e-052114229275212
Pubmed

Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains.

BRIP1 BRCA1

1.07e-052114215242590
Pubmed

Relationship between CD4+CD25+ Treg and expression of HIF-1α and Ki-67 in NSCLC patients.

HIF1A MKI67

1.07e-052114225967708
Pubmed

Correlations between the iodine concentrations from dual energy computed tomography and molecular markers Ki-67 and HIF-1α in rectal cancer: A preliminary study.

HIF1A MKI67

1.07e-052114229103468
Pubmed

Effects of acute hypoxia exposure with different durations on activation of Nrf2-ARE pathway in mouse skeletal muscle.

HIF1A NFE2L2

1.07e-052114230513114
Pubmed

Pharmacogenetics of the mycophenolic acid targets inosine monophosphate dehydrogenases IMPDH1 and IMPDH2: gene sequence variation and functional genomics.

IMPDH1 IMPDH2

1.07e-052114220718729
Pubmed

Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence.

BRIP1 BRCA1

1.07e-052114222137763
Pubmed

Two distinct cDNAs for human IMP dehydrogenase.

IMPDH1 IMPDH2

1.07e-05211421969416
Pubmed

Correlations between ADC values and molecular markers of Ki-67 and HIF-1α in hepatocellular carcinoma.

HIF1A MKI67

1.07e-052114226456310
Pubmed

Nrf2 is associated with the regulation of basal transcription activity of the BRCA1 gene.

BRCA1 NFE2L2

1.07e-052114223353771
Pubmed

Regulation of FTO and FTM expression during human preadipocyte differentiation.

RPGRIP1L FTO

1.07e-052114220865646
Pubmed

High frequency of HIF-1alpha overexpression in BRCA1 related breast cancer.

HIF1A BRCA1

1.07e-052114218030615
Pubmed

Kinetic analysis of interaction of BRCA1 tandem breast cancer c-terminal domains with phosphorylated peptides reveals two binding conformations.

BRIP1 BRCA1

1.07e-052114218717574
Pubmed

Hypoxia-induced TET1 facilitates trophoblast cell migration and invasion through HIF1α signaling pathway.

HIF1A TET1

1.07e-052114228808304
Pubmed

Characterization of human type I and type II IMP dehydrogenases.

IMPDH1 IMPDH2

1.07e-05211427903306
Pubmed

Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding.

IMPDH1 IMPDH2

1.07e-05211427763314
Pubmed

Genetic Nrf2 Overactivation Inhibits the Deleterious Effects Induced by Hepatocyte-Specific c-met Deletion during the Progression of NASH.

MET NFE2L2

1.07e-052114228676836
Pubmed

Macrophage metabolic adaptation to heme detoxification involves CO-dependent activation of the pentose phosphate pathway.

HIF1A NFE2L2

1.07e-052114232556090
Pubmed

Biochemical and immunomorphological evaluation of hepatocyte growth factor and c-Met pathway in patients with critical limb ischemia.

HIF1A MET

1.07e-052114224947080
Pubmed

Cholesterol Induces Nrf-2- and HIF-1α-Dependent Hepatocyte Proliferation and Liver Regeneration to Ameliorate Bile Acid Toxicity in Mouse Models of NASH and Fibrosis.

HIF1A NFE2L2

1.07e-052114232566088
Pubmed

Polymorphisms in type I and II inosine monophosphate dehydrogenase genes and association with clinical outcome in patients on mycophenolate mofetil.

IMPDH1 IMPDH2

1.07e-052114220679962
Pubmed

Expression of inosine monophosphate dehydrogenase type I and type II after mycophenolate mofetil treatment: a 2-year follow-up in kidney transplantation.

IMPDH1 IMPDH2

1.07e-052114217713475
Pubmed

Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling.

BRIP1 BRCA1

1.07e-052114215125843
Pubmed

Overactivated NRF2 induces pseudohypoxia in hepatocellular carcinoma by stabilizing HIF-1α.

HIF1A NFE2L2

1.07e-052114236460215
Pubmed

Mutants of purine metabolism in cultured mouse and hamster cells.

IMPDH1 IMPDH2

1.07e-0521142988789
Pubmed

Identification of a functional antioxidant response element at the HIF1A locus.

HIF1A NFE2L2

1.07e-052114230241031
Pubmed

Crystal Structure of Human Leukocyte Cell-derived Chemotaxin 2 (LECT2) Reveals a Mechanistic Basis of Functional Evolution in a Mammalian Protein with an M23 Metalloendopeptidase Fold.

LECT2 MET

1.07e-052114227334921
Pubmed

BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.

BRIP1 BRCA1

1.07e-052114222032289
Pubmed

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer.

BRIP1 BRCA1

1.07e-052114215133502
Pubmed

Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A.

HIF1A NDRG1 MKI67

2.26e-0517114317170753
Pubmed

FTO-Nrf2 axis regulates bisphenol F-induced leydig cell toxicity in an m6A-YTHDF2-dependent manner.

NFE2L2 FTO

3.19e-053114236878272
Pubmed

Characterization of cancer-linked BRCA1-BRCT missense variants and their interaction with phosphoprotein targets.

BRIP1 BRCA1

3.19e-053114219452558
Pubmed

Predicting Lymph Node Metastasis in Endometrial Cancer Using Serum CA125 Combined with Immunohistochemical Markers PR and Ki67, and a Comparison with Other Prediction Models.

MUC16 MKI67

3.19e-053114227163153
Pubmed

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.

BRIP1 BRCA1

3.19e-053114211301010
Pubmed

FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein.

BRIP1 BRCA1

3.19e-053114217596542
Pubmed

Epidermal growth factor receptor regulates MET levels and invasiveness through hypoxia-inducible factor-1alpha in non-small cell lung cancer cells.

HIF1A MET

3.19e-053114220154724
Pubmed

Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1.

NEIL2 NFE2L2

3.19e-053114224366543
Pubmed

Cervical Cancer Cell Line Secretome Highlights the Roles of Transforming Growth Factor-Beta-Induced Protein ig-h3, Peroxiredoxin-2, and NRF2 on Cervical Carcinogenesis.

TGFBI NFE2L2

3.19e-053114228261610
Pubmed

Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach.

BRIP1 BRCA1

3.19e-053114218285836
Pubmed

T cell activation triggers reversible inosine-5'-monophosphate dehydrogenase assembly.

IMPDH1 IMPDH2

3.19e-053114230154209
Pubmed

Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism.

HIF1A NFE2L2

3.19e-053114229153923
Pubmed

NRF2 and Hypoxia-Inducible Factors: Key Players in the Redox Control of Systemic Iron Homeostasis.

HIF1A NFE2L2

3.19e-053114232791852
Pubmed

Reduced Expression of TET1, TET2, TET3 and TDG mRNAs Are Associated with Poor Prognosis of Patients with Early Breast Cancer.

TDG TET1

3.19e-053114226207381
Pubmed

CDCA2 protects against oxidative stress by promoting BRCA1-NRF2 signaling in hepatocellular carcinoma.

BRCA1 NFE2L2

3.19e-053114234103686
Pubmed

Leukocyte cell-derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment.

LECT2 MET

3.19e-053114224114941
Pubmed

Genetic markers and continuity of healthy metabolic status: Tehran cardio-metabolic genetic study (TCGS).

SLC39A8 FTO

3.19e-053114232788640
Pubmed

Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation.

NEIL2 TDG

3.19e-053114226751644
Pubmed

UBXN7 cofactor of CRL3KEAP1 and CRL2VHL ubiquitin ligase complexes mediates reciprocal regulation of NRF2 and HIF-1α proteins.

HIF1A NFE2L2

3.19e-053114233444648
Pubmed

BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation.

HIF1A BRCA1

3.19e-053114230254159
Pubmed

FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links.

BRIP1 BRCA1

3.19e-053114232797166
Pubmed

Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA.

TDG TET1

3.19e-053114224838012
Pubmed

TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype.

TDG TET1

3.19e-053114236764492
Pubmed

MRI In rectal cancer: Correlations between MRI features and molecular markers Ki-67, HIF-1α, and VEGF.

HIF1A MKI67

3.19e-053114226919464
Pubmed

c-Myc-IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming.

IMPDH1 IMPDH2

3.19e-053114236629054
Pubmed

DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers.

NEIL2 BRCA1

3.19e-053114224698998
Pubmed

Prediction of BRCA1 germ-line mutation status in patients with breast cancer using histoprognosis grade, MS110, Lys27H3, vimentin, and KI67.

BRCA1 MKI67

3.19e-053114223614934
Pubmed

Reactive oxygen species regulate FSH-induced expression of vascular endothelial growth factor via Nrf2 and HIF1α signaling in human epithelial ovarian cancer.

HIF1A NFE2L2

3.19e-053114223404377
Pubmed

Polymorphisms in BRCA1, BRCA1-interacting genes and susceptibility of breast cancer in Chinese women.

BRIP1 BRCA1

3.19e-053114219484476
Pubmed

HIF-1 induction attenuates Nrf2-dependent IL-8 expression in human endothelial cells.

HIF1A NFE2L2

3.19e-053114219254160
Pubmed

Ascorbate depletion mediates up-regulation of hypoxia-associated proteins by cell density and nickel.

HIF1A NDRG1

3.19e-053114216288478
Pubmed

BRCA1, Ki67, and β-Catenin Immunoexpression Is Not Related to Differentiation, Platinum Response, or Prognosis in Women With Low- and High-Grade Serous Ovarian Carcinoma.

BRCA1 MKI67

3.19e-053114229465506
Pubmed

The LIM domain protein Lmo4 is highly expressed in proliferating mouse epithelial tissues.

DEAF1 MKI67

3.19e-053114215805422
Pubmed

MYCN and HIF-1 directly regulate TET1 expression to control 5-hmC gains and enhance neuroblastoma cell migration in hypoxia.

HIF1A TET1

3.19e-053114235942521
Pubmed

Identification of a MET-eIF4G1 translational regulation axis that controls HIF-1α levels under hypoxia.

HIF1A MET

3.19e-053114229717265
Pubmed

HIF-1α overexpression in ductal carcinoma in situ of the breast in BRCA1 and BRCA2 mutation carriers.

HIF1A BRCA1

3.19e-053114223409121
Pubmed

Ki-67 and p53 expression of the fallopian tube mucosa in breast cancer patients with hereditary risk.

BRCA1 MKI67

3.19e-053114224196303
Pubmed

BRCA1 and FancJ cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1.

BRIP1 BRCA1

3.19e-053114225483079
Pubmed

miR-125a induces apoptosis, metabolism disorder and migrationimpairment in pancreatic cancer cells by targeting Mfn2-related mitochondrial fission.

HIF1A MFN2

3.19e-053114229749475
Pubmed

Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease.

HIF1A CD79A

3.19e-053114229343683
Pubmed

CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication.

BRIP1 BRCA1

3.19e-053114223157317
Pubmed

Frequent met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis.

MET BRCA1

3.19e-053114216585167
Pubmed

Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2.

NID1 NDRG4

3.19e-053114233890711
Pubmed

Need (more than) two to Tango: Multiple tools to adapt to changes in oxygen availability.

HIF1A NFE2L2

3.19e-053114229485192
Pubmed

Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling.

CD79A TNPO3

3.19e-053114236167471
Pubmed

Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development.

RPGRIP1L FTO

3.19e-053114230728336
Pubmed

MiR-125b attenuates retinal pigment epithelium oxidative damage via targeting Nrf2/HIF-1α signal pathway.

HIF1A NFE2L2

3.19e-053114234875217
Pubmed

ZGRF1 promotes end resection of DNA homologous recombination via forming complex with BRCA1/EXO1.

ZGRF1 BRCA1

3.19e-053114234552057
Pubmed

Expressions of NDRG1, VEGF and Ki-67 in Condyloma Acuminatum.

NDRG1 MKI67

3.19e-053114227655496
Pubmed

CXCR4 promotes B cell viability by the cooperation of nuclear factor (erythroid-derived 2)-like 2 and hypoxia-inducible factor-1α under hypoxic conditions.

HIF1A NFE2L2

3.19e-053114233771976
GeneFamilyAnkyrin repeat domain containing|BRCA1 B complex

BRIP1 BRCA1

1.04e-0447621335
GeneFamilyDNA glycosylases

NEIL2 TDG

9.36e-04117621024
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

CSMD2 CR1 C6

1.77e-03577631179
GeneFamilyPotassium voltage-gated channel subfamily J

KCNJ1 KCNJ10

2.01e-0316762276
GeneFamilyRing finger proteins|Fanconi anemia complementation groups|Protein phosphatase 1 regulatory subunits|BRCA1 A complex|BRCA1 B complex|BRCA1 C complex

BRIP1 BRCA1

3.15e-0320762548
CoexpressionGSE23505_IL6_IL1_VS_IL6_IL1_IL23_TREATED_CD4_TCELL_DN

LDLRAD3 FOXJ3 POLR3F MED15 TNFAIP2 MED7 GNS NR1D2

2.58e-062001138M7859
CoexpressionAtlasfacebase_RNAseq_e14.5_palate_poster_distal_ERK2_WT_2500_K1

REC114 LAMA2 SEMA5A OAT KDM5D ADGRA2 PCDH17 RNF170 TGFBI MET PHC3 TLE2 TET1 GKAP1 CPXM1 METTL25 MBD5 CPLANE1

2.95e-05116611018facebase_RNAseq_e14.5_palate_poster_distal_ERK2_WT_2500_K1
CoexpressionAtlasdev gonad_e13.5_M_InterstitTestis_Sma_k-means-cluster#2_top-relative-expression-ranked_1000

BRIP1 ZGRF1 GLI3 TET1 MKI67

3.38e-05711105gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_k2_1000
CoexpressionAtlasB cells, proB.CLP.BM, CD19- IgM- CD43+ CD24- AA4.1+ CD45R- CD117+ IL7R+, Bone marrow, avg-1

BRIP1 IMPDH2 SCRG1 SH2D5 TGFBI BRCA1 TET1 MKI67 CD79A TNFAIP2

4.91e-0540511010GSM538343_500
CoexpressionAtlasFacebaseRNAseq_e9.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#1

C15orf62 ZNF157 LAMA2 SEMA5A OAT ADGRA2 HOXA2 TGFBI PHC3 CPXM1 NID1 FTO

5.50e-0558911012Facebase_RNAseq_e9.5_Maxillary Arch_2500_K1
CoexpressionAtlasdev gonad_e13.5_F_MeioticGermCell_Oct_k-means-cluster#2_top-relative-expression-ranked_1000

BRIP1 REC114 ZGRF1 BRCA1 SUV39H1 GKAP1 METTL25 CPLANE1 NR1D2

1.10e-043611109gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_k2_1000
CoexpressionAtlasFacebaseRNAseq_e9.5_Facial Mesenchyne_top-relative-expression-ranked_2500_k-means-cluster#2

C15orf62 ZNF157 LAMA2 SEMA5A OAT ADGRA2 SLC39A8 TGFBI PHC3 CPXM1 NID1 FTO

1.24e-0464211012Facebase_RNAseq_e9.5_Facial Mesenchyne_2500_K2
CoexpressionAtlasFacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#4

C15orf62 TES LAMA2 SEMA5A OAT ADGRA2 SLC39A8 PHC3 GLI3 MKI67 CPXM1 NID1 FTO

1.26e-0474411013Facebase_RNAseq_e10.5_Medial Nasal Eminence_2500_K4
ToppCellsevere-HLA-DR+_CD83+_Monocyte|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

HIF1A SRGAP2 CR1 JMJD1C MET TNFAIP2 GNS

7.95e-071981147d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

OSTM1 LDLRAD3 SUV39H1 TNFAIP2 MBD5 CPLANE1

4.74e-06168114627cdf5cfa1d906868cfd60fdfab3cd51f3b3602f
ToppCellfacs-Lung-Endomucin-3m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRAG1 F8 LAX1 LRIG2 NDRG1 KCNJ1

5.42e-061721146b3c4adccc34bb9e4e78e40f4e2e23736c347cc75
ToppCellfacs-Lung-Endomucin-3m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRAG1 F8 LAX1 LRIG2 NDRG1 KCNJ1

5.42e-0617211462f1673fcb2356684d60871debb0f159aec553a1c
ToppCelldroplet-Spleen-SPLEEN-30m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LDLRAD3 TGFBI MET NDRG1 MKI67 TNFAIP2

6.60e-061781146be8af4d85b8835a85a168639c37857dcaa6b00bf
ToppCellPBMC-Control-cDC_12|Control / Compartment, Disease Groups and Clusters

BRIP1 SLC39A8 BRCA1 KCNJ10 SUV39H1 MKI67

7.49e-0618211464774066d0f9986abc3d13a2a3bc99ce4f1327ae0
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BRIP1 ZGRF1 ADGRA2 BRCA1 GLI3 MKI67

8.74e-061871146e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

BRIP1 ZGRF1 ADGRA2 BRCA1 GLI3 MKI67

8.74e-061871146cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 JMJD1C TGFBI PRRC2C CPXM1 NID1

1.02e-05192114611088878043a6ff95ba1970361256a82e434b80a
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 SEMA5A TGFBI CPXM1 NID1 NDRG4

1.02e-051921146beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

HIF1A LDLRAD3 ADGRE2 PRAG1 TGFBI MET

1.02e-0519211468b86db2ebe0199fee0e9800566a619a24bfdeed5
ToppCell368C-Lymphocytic-NK_cells-Proliferating_NK_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

BRIP1 ZGRF1 SUV39H1 MKI67 CPXM1 CPLANE1

1.05e-0519311465f5904cec8b2967154ef2eab3c48f51df53aca4a
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HIF1A ADGRE2 CR1 MCOLN1 JMJD1C TNFAIP2

1.08e-051941146dfe0ece81922bfd7c6673726d3ea2365cbdb5513
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA2 SEMA5A LDLRAD3 ADGRA2 TGFBI NID1

1.11e-051951146d8ebb94f30d4a655d6b29dd6a3076be2403d2356
ToppCell5'-Adult-Appendix|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HIF1A LAMA2 F8 CPXM1 NID1 TNFAIP2

1.14e-051961146a579211ef14f348d0c5a290553150222dfbf1515
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IMPDH2 CAMK2B SEMA5A OAT FAT2 NFE2L2

1.21e-051981146b411fb9f16eb641593f546c5f3a0db37b05c1f4f
ToppCellNeuronal-Excitatory-eC(RORB)-eC_1-CARM1P1--L3-4|Neuronal / cells hierarchy compared to all cells using T-Statistic

LAMA2 SCRG1 PRAG1 SLC39A8 TGFBI MET

1.28e-05200114647791c93d03ee17c1ce17e27f075be4fc6f2590e
ToppCellTransverse-(2)_B_cell-(24)_B_cell_cycling|Transverse / shred on region, Cell_type, and subtype

BRIP1 CR1 FOXJ3 BRCA1 SUV39H1 MKI67

1.28e-052001146e3f9736227151f23f0e331eec0a7a15ce464b517
ToppCellTransverse-B_cell-B_cell_cycling|Transverse / Region, Cell class and subclass

BRIP1 CR1 FOXJ3 BRCA1 SUV39H1 MKI67

1.28e-0520011460e270f8019d9f22068ca426d661937262a5cd331
ToppCellNeuronal-Excitatory-eC(RORB)-eC_1-CARM1P1|Neuronal / cells hierarchy compared to all cells using T-Statistic

LAMA2 SCRG1 PRAG1 SLC39A8 TGFBI MET

1.28e-052001146f75d95376a340d467c4392b872b2a2dbdd184556
ToppCellNeuronal-Excitatory-eC(RORB)-eC_1-CARM1P1-|Neuronal / cells hierarchy compared to all cells using T-Statistic

LAMA2 SCRG1 PRAG1 SLC39A8 TGFBI MET

1.28e-052001146fae26560ba3b0b638b6bcf92f05330824b31d21b
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-3|TCGA-Brain / Sample_Type by Project: Shred V9

CSMD2 JMJD1C LRIG2 NTN4 EYS

2.55e-0513511453351e8b9e417397c5fa9f856184ff24ce1a27242
ToppCellprimary_visual_cortex-Non-neuronal-astrocyte|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

LAMA2 SCRG1 NFE2L2 GLI3 KCNJ10

4.64e-05153114595b28c5bd10ffb74c0993ebd565038b9818e4bd2
ToppCellprimary_visual_cortex-Non-neuronal-astrocyte-Astro|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

LAMA2 SCRG1 NFE2L2 GLI3 KCNJ10

4.64e-051531145b09f8def40a1ea56722f3398f61a036667b61cd9
ToppCellprimary_visual_cortex-Non-neuronal-astrocyte-Astro-Astro_Aqp4|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

LAMA2 SCRG1 NFE2L2 GLI3 KCNJ10

4.64e-0515311453ab9d55b3db51715c1d61eca142384195ce4b54f
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CUBN PRAG1 TGFBI TNFAIP2 GNS

5.41e-0515811456811dc4f101dfa9a9cc13d949760d43aa522bf3b
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

LAMA2 TGFBI CPXM1 NID1 TNFAIP2

5.57e-051591145cb2470b288c13e454a2a80115b0d5613b3f718e6
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZGRF1 F8 PCDH17 BRCA1 MKI67

6.27e-0516311453efbbdc9cb2613bb76d8c2f07cd4ec1a2c51a622
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TES NEIL2 ZNF280B ZNF850 ZNF782

6.45e-0516411454ade97931ae1780af7836d988fe117a10b3e88a1
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BRIP1 ZGRF1 HOXA2 BRCA1 MKI67

6.64e-05165114588681101d7cf60b99b8ace5d8c0944323b937306
ToppCell5'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C15orf62 MUC16 NTN4 NDRG1 KLHL14

7.03e-051671145720dc5855c856b478b5ca90156b30bfcc5518d60
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LDLRAD3 TGFBI NTN4 GLI3 CPXM1

7.43e-0516911457cb1b87be66a22fe5731bb1b55bc515920fe3e8b
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LDLRAD3 TGFBI KCNJ10 TNFAIP2 C6

7.64e-051701145a121e10099faaeb60251eec162f38caf7c4238c2
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

C15orf62 BRIP1 SUV39H1 MKI67 MED7

7.64e-05170114521bfe070e63722672176052b386167ea4c3dc4e5
ToppCellfacs-Marrow-T-cells-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SRGAP2 LDLRAD3 LECT2 TGFBI MET

7.64e-051701145a78d9789c3e7c84a36e1bd380192d7aba4a4d443
ToppCellfacs-Marrow-T-cells-3m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SRGAP2 LDLRAD3 LECT2 TGFBI MET

7.64e-051701145ff68600b945b3a5437b14e5411b3db800d0ccbe5
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZAN KCNJ10 MKI67 TNFAIP2 GNS

7.86e-051711145845f312f8cbe29d820da25f0e6d75deb382bbfd8
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BRIP1 ZGRF1 LAMA2 SCRG1 MKI67

7.86e-051711145b0373ed8283ee1792b6a490bff93906546978593
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BRIP1 ZGRF1 LAMA2 SCRG1 MKI67

7.86e-051711145b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ZNF280B SPACA9 PCDH17 ZNF782 GNS

8.08e-051721145d65ffff3e341af34a043a0d802d7ba4b69de36e9
ToppCelldroplet-Liver-nan-3m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA5A PLPPR1 KCNJ10 TNFAIP2 C6

8.08e-0517211451f335ccb92b22d0412954e8fc3af212f96410b67
ToppCelldroplet-Liver-nan-3m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA5A PLPPR1 KCNJ10 TNFAIP2 C6

8.08e-051721145bb96c896d125e10b71e94e2bdad243899045af5c
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LAMA2 SCRG1 SLC39A8 TGFBI MET

8.30e-0517311458ac2e9d39c0f76e674f8bd59d1da246bab4867c8
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BRIP1 ZGRF1 PCDH17 BRCA1 MKI67

8.53e-05174114566555c610251ea04f968c258e312d720c18e7cde
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LAMA2 SEMA5A LDLRAD3 PRAG1 TGFBI

8.76e-0517511453f233a7e19f594e0343f02286299cc42c711994c
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LAMA2 SEMA5A LDLRAD3 PRAG1 TGFBI

8.76e-05175114523acfbcc1eb5a066195a9fde20aa51b7303a81af
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-14|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

METAP1D KDM5D CD79A ZNF606 METTL25

8.76e-05175114587e557f7508c88b2087db5d57e77d5e2c92ca083
ToppCelldroplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LDLRAD3 TGFBI KCNJ10 TNFAIP2 C6

8.76e-051751145f7cd2ef79d91d64976fcdb5f1e7343b24ba27456
ToppCellprimary_visual_cortex-Non-neuronal|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

LAMA2 SCRG1 NFE2L2 GLI3 KCNJ10

9.00e-0517611452c92f3f55d668cfe80051b5128160a6dc3aec4e8
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

C15orf62 ADGRE2 CR1 TGFBI GNS

9.24e-051771145382f0d6bbff01e84b0c7840e74ac865864e6da89
ToppCell3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SCRG1 ADGRA2 PCDH17 HOXA2 NTN4

9.24e-0517711451921226196b2ab7919d9f843e60d9f4bd9ec9c57
ToppCelldroplet-Lung-nan-3m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BRIP1 ZGRF1 SPEG PRAG1 MCOLN1

9.49e-051781145de6cd81e6d58e7687386df163471bf1901b9c0aa
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHYKPL KCNJ1 CD79A KLHL14

9.59e-05931144096a207dfd280b23480bc068a15e6947423620c5
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHYKPL KCNJ1 CD79A KLHL14

9.59e-059311446977ae7eccb45fbc48960a0945be9ccc7566ca8b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SEMA5A CUBN SLC39A8 MET TNFAIP2

9.75e-05179114558ae5a97fe2a14e1c6fdeb886397eb06fdaf0428
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-LYVE1+_Macrophage|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SRGAP2 ADGRE2 SSPOP TGFBI TNFAIP2

1.00e-04180114566c7b02d85e32ba3e7530d0c4aff17e7525ccdd8
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

BRIP1 ZGRF1 CSMD2 BRCA1 MKI67

1.00e-041801145f8a15c13d85c1bbbf86ce49bb6f86c368ddf22df
ToppCelldroplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCKAP1 ADGRA2 F8 PCDH17 NID1

1.08e-041831145709a486154b3157427deb3b8886b63ac39ea42dd
ToppCelldroplet-Liver-nan-3m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCKAP1 ADGRA2 F8 PCDH17 NID1

1.08e-041831145dc06f19f6f80f4c7f13f1f990c1fe0f91ba64ea7
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HIF1A LDLRAD3 ADGRE2 CR1 TGFBI

1.11e-041841145d1ea2b60fb1ca1a0b809d131310c43903a9e84ce
ToppCellNS-critical-LOC-Epithelial-Basal|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NCKAP1 OAT PCDH17 FAT2 TLE2

1.17e-041861145c28f62524637c7eb9c43c9ec38fb12dfec6f5566
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neuron_precursor-cycling_neuroblast|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BRIP1 PCDH17 CRB1 BRCA1 MKI67

1.17e-0418611454fe8e0bf74c7dbf73634cafdacad89020d2634d0
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SPEG SEMA5A PRAG1 TGFBI TLE2

1.20e-041871145387cb27c8a20031cd87381a9e1172f1f62e1488b
ToppCellCOVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

F8 PCDH17 MET NDRG1 NDRG4

1.20e-0418711452d20193a6cacdfa4877457c97b0077408942186c
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-D|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CR1 SLC39A8 TGFBI TNFAIP2 GNS

1.23e-0418811455f6ad5d693145d846ca561c2fa55465a88e40b90
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 SH2D5 HOXA2 CPXM1 NID1

1.26e-041891145544d95df910f1b276995624509a7e41b219baca0
ToppCellControl-Myeloid-MoAM1|Control / Disease group,lineage and cell class (2021.01.30)

HIF1A ADGRE2 SSPOP SLC39A8 TGFBI

1.26e-04189114555d5c2fb9e6ab556d42c83a1e985ee66e4cf9dba
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_monocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HIF1A ADGRE2 MCOLN1 TGFBI TNFAIP2

1.29e-04190114500ef6ec71353e42260c0d807d7da65b63154c288
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HIF1A ADGRE2 MCOLN1 TGFBI TNFAIP2

1.29e-04190114518c020ca9a23399214133ec255ab870e0060f2e1
ToppCellwk_08-11-Epithelial-PNS-Early_Schwann|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SCRG1 LENG9 KYAT1 PCDH17 KCNJ10

1.29e-0419011458190674a48607984726974765aafbca116f437e0
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-intestinal_crypt_stem_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB38 IMPDH2 SEMA5A PRRC2C MKI67

1.29e-04190114552c59001a079c76249abbaa3141e9e661b83d9a0
ToppCelldroplet-Limb_Muscle-nan-24m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 TGFBI CPXM1 NID1 TNFAIP2

1.29e-041901145ad0f5605db6b694445ec9bd5dc8d2d834358c0f9
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 NTN4 PRRC2C NID1 TNFAIP2

1.32e-0419111457d1595e616f6f111fc2f5bc1b179c5d67d624cc9
ToppCellPBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ADGRE2 CR1 TGFBI TNFAIP2 GNS

1.32e-041911145c9f3bdb5c0a90268cab24a0fe4c3a8290fcedeb8
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA2 LDLRAD3 ADGRA2 GLI3 NID1

1.32e-0419111457b0d42a877540dbb346a76a62403e0d5d3e07fa6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA2 LDLRAD3 ADGRA2 GLI3 NID1

1.32e-041911145cd854b9c426924fdc84bf7f411f6dea447143e79
ToppCellPBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ADGRE2 CR1 TGFBI TNFAIP2 GNS

1.35e-041921145b86476037ddf8904c1d8a6b3763af7242c031cf3
ToppCelldroplet-Liver-HEPATOCYTES-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRA2 F8 SLC39A8 PCDH17 NID1

1.35e-0419211455890076929598e88fe9d59a4e4e858b446746ce9
ToppCellFibroblasts-CD55+_Fibroblasts|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

NCKAP1 SPEG SEMA5A MET NTN4

1.39e-0419311458f4bf9a2fbedae35432dad96730b00c70185874c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA2 LDLRAD3 ADGRA2 GLI3 NID1

1.39e-041931145f1199518c3626fd29bfce65070dd21a660671213
ToppCelldroplet-Pancreas-Endocrine-21m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 ADGRA2 GLI3 CPXM1 NID1

1.39e-04193114559b8186d0221fba06a16157e9d148399ed801f38
ToppCelldroplet-Liver-HEPATOCYTES-1m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRA2 F8 SLC39A8 PCDH17 NID1

1.39e-0419311454a8c97ff2dffc5c06351d1cb107e21e58250aa55
ToppCelldroplet-Liver-HEPATOCYTES-1m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADGRA2 F8 SLC39A8 PCDH17 NID1

1.39e-041931145d5f6d6e2c36d4e80af4d39cdfc0b18df295a587b
ToppCelldroplet-Pancreas-Endocrine-21m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 ADGRA2 GLI3 CPXM1 NID1

1.39e-041931145dc92680b4bb9fc26430c92e03adb839c8c3b3b98
ToppCelldroplet-Pancreas-Endocrine-21m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 ADGRA2 GLI3 CPXM1 NID1

1.39e-04193114503678162648bd5b1d65a5450b60c8863edbf95c7
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

PLPPR1 PRAG1 NDRG1 PRRC2C MBD5

1.39e-041931145e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCellmetastatic_Brain-Fibroblasts-Pericytes|metastatic_Brain / Location, Cell class and cell subclass

LAMA2 SEMA5A ADGRA2 CPXM1 NID1

1.42e-041941145d1889a3e22d5b88461c81ec3ea0e74bb9bf63e60
ToppCellNon-neuronal-Non-dividing|World / Primary Cells by Cluster

SCRG1 SEMA5A OAT NFE2L2 GLI3

1.42e-0419411450add09d97192b34bd506209ab5f1a77182f498fc
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA2 LDLRAD3 ADGRA2 GLI3 NID1

1.45e-041951145d9a5c75d31c6e8bb1e1ab7fd115ac5deb5fb1c8d
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB38 LAMA2 JMJD1C PRRC2C CPXM1

1.45e-0419511455c86fddd6d0530beecf45ea5ba6b823123847696
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SPEG LAMA2 LDLRAD3 ADGRA2 NID1

1.49e-041961145b8759e6231e0254797d6c30930407b79440c57bb
ToppCelldroplet-Heart-HEART-1m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPEG LAMA2 SEMA5A NDRG4 NR1D2

1.49e-0419611451eb14182ef26e6141f510d397b00bf8a12efda3e
ToppCellfacs-Lung-nan|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 TGFBI CPXM1 NID1 NR1D2

1.49e-041961145b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCellCOVID-19-lung-Macrophage_CD163hi_MERTKhi|COVID-19 / Disease (COVID-19 only), tissue and cell type

ADGRE2 CR1 MCOLN1 TGFBI TNFAIP2

1.49e-0419611457026c1fc33425e5476063d17c79e4b79356a9e01
ToppCellfacs-Lung-nan-3m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 TGFBI CPXM1 NID1 NR1D2

1.49e-041961145787c6cd92035e0b1108c2c086c42a229016e476b
ToppCellfacs-Trachea-3m|Trachea / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HIF1A NCKAP1 COPB2 JMJD1C PTPRA

1.53e-041971145e77016d64b1cac9825fec7cfe5071f1567401187
ToppCellfacs-Trachea-nan-3m|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIF1A NCKAP1 COPB2 JMJD1C PTPRA

1.53e-0419711450353d925ee4b7aefc2c51b5fab873f465cdf9ebc
ToppCellcontrol-Myeloid-Non-resident_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

HIF1A ADGRE2 CR1 JMJD1C TNFAIP2

1.53e-041971145df2fe36cb96e2565a9d21c24cb4e451e8befd4be
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BRIP1 ZAN PCDH17 MKI67 NID1

1.53e-04197114576b61e60a757e58b465569538e632d6d9953e89a
ToppCellSepsis-ICU-NoSEP-Lymphocyte-B-Plasmablast|ICU-NoSEP / Disease, condition lineage and cell class

BRIP1 LAX1 CPXM1 CD79A KLHL14

1.53e-0419711458f35f9741086a38f0e594dce0547b575946f52bb
DrugCeftazidime pentahydrate [78439-06-2]; Up 200; 6.2uM; PC3; HT_HG-U133A

SPEG SEMA5A ZNF280B KYAT1 MET CD79A TNFAIP2 CPLANE1

6.85e-0619711485054_UP
DrugOleandomycin phosphate [7060-74-4]; Down 200; 5uM; PC3; HT_HG-U133A

FOXJ3 TGFBI MET PHC3 KCNJ1 CD79A ZNF606 NDRG4

7.38e-0619911484615_DN
DrugAC1L1BVU

F8 BRCA1 CD79A C6

1.11e-05281144CID000001631
Drug1 mN-9

IMPDH1 IMPDH2 NDRG1

1.43e-05101143CID000122108
DrugVanadates

HIF1A TES CAMK2B ZNF280B KDM5D PRAG1 KYAT1 HOXA2 TGFBI MET NTN4 BRCA1 GLI3 GKAP1 NID1 CD79A TNFAIP2 FTO CPLANE1

2.41e-05130211419ctd:D014638
Drughydroxymethylphosphonate

IMPDH1 IMPDH2

2.49e-0521142CID000075795
Drug6-Chloropurine Riboside, 5'-Monophosphate

IMPDH1 IMPDH2

2.49e-0521142DB03948
DrugMycophenolate mofetil

IMPDH1 IMPDH2

2.49e-0521142DB00688
Drugpurinogen

IMPDH1 IMPDH2

2.49e-0521142CID003081226
DrugAC1L9X6T

IMPDH1 IMPDH2

2.49e-0521142CID000477594
DrugMycophenolic acid

IMPDH1 IMPDH2

2.49e-0521142DB01024
Drug6-thioxanthine

IMPDH1 IMPDH2 KYAT1

2.60e-05121143CID001268107
Druggabaculine

PHYKPL OAT CPXM1 C6

2.77e-05351144CID000003445
DrugAC1L1IFV

HIF1A KDM5D PHC3 SUV39H1 CD79A

4.83e-05791145CID000004561
DrugClobetasol propionate [25122-46-7]; Down 200; 8.6uM; MCF7; HT_HG-U133A

BRIP1 SLC39A8 MET PHC3 RNFT1 MFN2 GNS

5.40e-0519311476835_DN
DrugCinchonine [118-10-5]; Down 200; 13.6uM; MCF7; HT_HG-U133A

RPGRIP1L SPACA9 LAX1 MED15 PHC3 PTPRA TLE2

5.58e-0519411474107_DN
DrugBetazole hydrochloride; Down 200; 27uM; PC3; HT_HG-U133A

NCKAP1 GNB1L RNF170 MET NID1 TNFAIP2 NDRG4

5.95e-0519611476344_DN
DrugMifepristone [84371-65-3]; Down 200; 9.4uM; MCF7; HT_HG-U133A

SLC4A2 MED15 PHC3 NDRG1 GLI3 SUV39H1 NDRG4

5.95e-0519611477183_DN
DrugBepridil hydrochloride [74764-40-2]; Down 200; 10uM; PC3; HT_HG-U133A

BRIP1 GNB1L RXYLT1 MET TLE2 MFN2 NID1

6.15e-0519711474613_DN
DrugPicotamide monohydrate [80530-63-8]; Down 200; 10.2uM; PC3; HT_HG-U133A

BRIP1 GNB1L RNF170 MET RNFT1 MKI67 NID1

6.15e-0519711472070_DN
DrugPropranolol hydrochloride [318-98-9]; Down 200; 13.6uM; PC3; HT_HG-U133A

BRIP1 RPGRIP1L SEMA5A FOXJ3 MET TLE2 TNFAIP2

6.55e-0519911476759_DN
DrugMoxalactam disodium salt [64953-12-4]; Up 200; 7uM; PC3; HT_HG-U133A

LAMA2 PHF7 ZNF280B SPACA9 CR1 MET TNFAIP2

6.55e-0519911474648_UP
Drugclofibrate; Up 200; 100uM; MCF7; HG-U133A

SEMA5A MET PTPRA BRCA1 TTLL4 RNFT1 NDRG4

6.55e-051991147444_UP
DrugHippeastrine hydrobromide [22352-41-6]; Down 200; 10uM; PC3; HT_HG-U133A

CAMK2B PHF7 SPACA9 LAX1 PCDH17 HOXA2 CPLANE1

6.76e-0520011473682_DN
DrugAC1L59F0

IMPDH1 IMPDH2

7.43e-0531142CID000220847
Drugtoxin 6

CD79A GNS

7.43e-0531142CID000126627
DrugAC1L9X6Q

IMPDH1 IMPDH2

7.43e-0531142CID000477593
Drugoxanosine-5'-monophosphate

IMPDH1 IMPDH2

7.43e-0531142CID000477551
Drugglutamate

PHYKPL IMPDH1 CAMK2B OAT TDG MCOLN1 LECT2 NDUFV1 KYAT1 SLC4A2 NTN4 NFE2L2 KCNJ1 KCNJ10 TTLL4

9.16e-0596211415CID000000611
Diseaselevel of leukocyte cell-derived chemotaxin-2 in blood serum

LECT2 TGFBI

1.43e-0521122OBA_2042187
DiseaseMultiple Hemangioblastomas

HIF1A NDRG1

1.43e-0521122C0751692
DiseaseHemangioblastoma

HIF1A NDRG1

1.43e-0521122C0206734
DiseaseDisorder of eye

RPGRIP1L IMPDH1 OAT CRB1 EYS MFN2 CPLANE1

1.71e-052121127C0015397
DiseaseChromosome Breakage

BRCA1 NFE2L2 SUV39H1

1.88e-05141123C0376628
DiseaseChromosome Breaks

BRCA1 NFE2L2 SUV39H1

1.88e-05141123C0333704
Diseasediabetic retinopathy (implicated_via_orthology)

HIF1A NFE2L2 KCNJ10

2.88e-05161123DOID:8947 (implicated_via_orthology)
DiseasePrimary biliary cirrhosis

HIF1A SLC4A2 NFE2L2 TNPO3

3.09e-05471124C0008312
DiseaseCerebral Astrocytoma

HIF1A MET NDRG1

1.15e-04251123C0750935
DiseaseIntracranial Astrocytoma

HIF1A MET NDRG1

1.15e-04251123C0750936
DiseaseAstrocytoma

HIF1A MET NDRG1

1.15e-04251123C0004114
DiseaseGrade I Astrocytoma

HIF1A MET NDRG1

1.15e-04251123C1704230
DiseaseSubependymal Giant Cell Astrocytoma

HIF1A MET NDRG1

1.15e-04251123C0205768
DiseaseMixed oligoastrocytoma

HIF1A MET NDRG1

1.15e-04251123C0547065
DiseasePilocytic Astrocytoma

HIF1A MET NDRG1

1.15e-04251123C0334583
DiseaseJuvenile Pilocytic Astrocytoma

HIF1A MET NDRG1

1.15e-04251123C0280783
DiseaseDiffuse Astrocytoma

HIF1A MET NDRG1

1.15e-04251123C0280785
DiseaseChildhood Cerebral Astrocytoma

HIF1A MET NDRG1

1.15e-04251123C0338070
DiseaseGemistocytic astrocytoma

HIF1A MET NDRG1

1.30e-04261123C0334581
DiseaseProtoplasmic astrocytoma

HIF1A MET NDRG1

1.30e-04261123C0334580
DiseaseFibrillary Astrocytoma

HIF1A MET NDRG1

1.30e-04261123C0334582
DiseaseAnaplastic astrocytoma

HIF1A MET NDRG1

1.46e-04271123C0334579
Diseaseovarian neoplasm

BRIP1 MUC16 MET BRCA1 MKI67

1.63e-041341125C0919267
DiseaseMalignant neoplasm of ovary

BRIP1 MUC16 MET BRCA1 MKI67

1.81e-041371125C1140680
Diseasegrowth/differentiation factor 5 measurement

LECT2 TGFBI

2.12e-0461122EFO_0020429
DiseaseGlioblastoma

HIF1A TES MET NDRG1

2.37e-04791124C0017636
DiseaseGiant Cell Glioblastoma

HIF1A TES MET NDRG1

3.00e-04841124C0334588
DiseaseCongenital Amaurosis of Retinal Origin

IMPDH1 CRB1

3.94e-0481122C3540662
Diseasetransforming growth factor-beta-induced protein ig-h3 measurement

LECT2 TGFBI

3.94e-0481122EFO_0008302
Diseasecreatinine measurement

HIF1A BRIP1 IMPDH2 SPEG LAMA2 PHF7 CUBN BIRC6 NDRG1 NFE2L2 PRRC2C MBD5

4.05e-0499511212EFO_0004518
DiseaseNodular glomerulosclerosis

TGFBI NFE2L2 MFN2

5.11e-04411123C0017667
DiseaseSchizophrenia

CAMK2B GNB1L LAMA2 CSMD2 NDUFV1 PCDH17 MED15 MET PTPRA BRCA1 TET1

5.45e-0488311211C0036341
DiseaseSecondary Biliary Cholangitis

HIF1A SLC4A2 NFE2L2

5.49e-04421123C0238065
DiseaseBiliary cirrhosis

HIF1A SLC4A2 NFE2L2

5.49e-04421123C0023892
DiseaseBiliary Cirrhosis, Primary, 1

HIF1A SLC4A2 NFE2L2

5.49e-04421123C4551595
Diseaseasthma

ZBTB38 SPEM2 MUC16 SRGAP2 LDLRAD3 PRAG1 JMJD1C CRB1 GLI3 METTL25

5.90e-0475111210MONDO_0004979
DiseaseDiabetic Nephropathy

TGFBI NFE2L2 MFN2

6.29e-04441123C0011881
DiseaseMalignant neoplasm of kidney

KYAT1 MET NDRG1

6.73e-04451123C0740457
Diseasediabetic retinopathy (biomarker_via_orthology)

HIF1A KCNJ10 MFN2

6.73e-04451123DOID:8947 (biomarker_via_orthology)
DiseaseCopper-Overload Cirrhosis

MET MKI67

7.68e-04111122C1876165
Diseasecognitive decline measurement, memory performance, language measurement

GLI3 TNFAIP2

7.68e-04111122EFO_0004874, EFO_0007710, EFO_0007797
DiseaseHypermetropia, Myopia

ZBTB38 LAMA2 METAP1D CUBN TNPO3

7.88e-041891125HP_0000540, HP_0000545
DiseaseMalignant neoplasm of breast

HIF1A BRIP1 GNB1L LAMA2 PHF7 CUBN MCOLN1 NDRG1 BRCA1 KCNJ1 MKI67 FTO

7.94e-04107411212C0006142
DiseaseCiliopathies

RPGRIP1L IMPDH1 CRB1 CPLANE1

8.33e-041101124C4277690
DiseaseGlioblastoma Multiforme

HIF1A TES MET NDRG1

8.62e-041111124C1621958
Diseaseresponse to fenofibrate

JMJD1C GLI3 C6

9.16e-04501123GO_1901557
Diseaseprediabetes syndrome (biomarker_via_orthology)

SLC4A2 MFN2

9.19e-04121122DOID:11716 (biomarker_via_orthology)
DiseaseSquamous cell carcinoma of the head and neck

MET NDRG1 NFE2L2

1.03e-03521123C1168401
Diseaseblood nickel measurement

MUC16 PLPPR1 EYS FAT2

1.15e-031201124EFO_0007583
DiseaseHereditary Breast and Ovarian Cancer Syndrome

BRIP1 BRCA1

1.26e-03141122C0677776
Diseaserefractive error

ZBTB38 LAMA2 SCRG1 METAP1D SLC39A8 KCNJ1

1.56e-033261126MONDO_0004892
Diseaseacute kidney failure (biomarker_via_orthology)

HIF1A MET NFE2L2

1.63e-03611123DOID:3021 (biomarker_via_orthology)
DiseaseLeber congenital amaurosis

IMPDH1 CRB1

1.65e-03161122cv:C0339527
Diseaseidiopathic scoliosis (implicated_via_orthology)

SSPOP SLC39A8

1.65e-03161122DOID:0060250 (implicated_via_orthology)
Diseasetype 2 diabetes mellitus (is_marker_for)

HIF1A F8 MFN2 FTO

1.83e-031361124DOID:9352 (is_marker_for)
Diseasepre-malignant neoplasm (biomarker_via_orthology)

GLI3 SUV39H1

1.87e-03171122DOID:0060071 (biomarker_via_orthology)
Diseasecholangiocarcinoma (is_marker_for)

MUC16 MET MKI67

1.87e-03641123DOID:4947 (is_marker_for)
Diseasetype 2 diabetes mellitus (biomarker_via_orthology)

HIF1A NFE2L2 MKI67 FTO

2.42e-031471124DOID:9352 (biomarker_via_orthology)
Diseasesarcopenia

LDLRAD3 FTO

2.59e-03201122EFO_1000653
DiseaseFamilial aplasia of the vermis

RPGRIP1L CPLANE1

2.59e-03201122cv:C0431399
Diseasepentachlorophenol measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022071
Diseaseparathion measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022070
Diseasepotassium chromate measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022072
Diseasemercuric chloride measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022068
Diseaseheptachlor epoxide measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022067
Diseasemethoxychlor measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022069
Disease4,6-dinitro-o-cresol measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022053
Disease2,4,5-trichlorophenol measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022052
Diseaseazinphos methyl measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022055
Diseasealdrin measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022054
Diseasedicofol measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022060
Diseasedisulfoton measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022062
Diseasedieldrin measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022061
Diseaseendrin measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022064
Diseaseendosulfan measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022063
Diseaseheptachlor measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022066
Diseaseethion measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022065
Diseasechlorpyrifos measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022057
Diseasecadmium chloride measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022056
Diseasediazinon measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022059
Diseasedibutyl phthalate measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0022058
Diseaseenvironmental exposure measurement

MUC16 PLPPR1 EYS

2.73e-03731123EFO_0008360
DiseaseRetinitis pigmentosa

IMPDH1 CRB1 EYS

2.84e-03741123cv:C0035334
DiseaseDDT metabolite measurement

MUC16 PLPPR1 EYS

2.84e-03741123EFO_0007886
DiseaseLeft Ventricle Remodeling

NFE2L2 MFN2

2.86e-03211122C0600520
DiseaseVentricular Remodeling

NFE2L2 MFN2

2.86e-03211122C0600519
Diseasekidney disease (biomarker_via_orthology)

TGFBI MKI67

2.86e-03211122DOID:557 (biomarker_via_orthology)
DiseaseBREAST CANCER

BRIP1 BRCA1

2.86e-03211122114480
DiseaseMental Depression

HIF1A DEAF1 CSMD2 BRCA1 FTO

2.89e-032541125C0011570
DiseaseNon-Small Cell Lung Carcinoma

HIF1A MET NDRG1 NFE2L2

3.00e-031561124C0007131
Diseasetransient cerebral ischemia (biomarker_via_orthology)

HIF1A KCNJ10 MFN2 FTO

3.07e-031571124DOID:224 (biomarker_via_orthology)
Diseasenucleus accumbens volume

BIRC6 SLC39A8

3.14e-03221122EFO_0006931
DiseaseHepatitis, Chronic

MET MKI67

3.14e-03221122C0019189
DiseaseChronic active hepatitis

MET MKI67

3.14e-03221122C0520463
DiseaseChronic Persistent Hepatitis

MET MKI67

3.14e-03221122C0149519
DiseaseLeber Congenital Amaurosis

IMPDH1 CRB1

3.14e-03221122C0339527
DiseaseCryptogenic Chronic Hepatitis

MET MKI67

3.14e-03221122C0524611
DiseaseCarcinomatosis

HIF1A KYAT1 MET BRCA1

3.51e-031631124C0205699
DiseaseCarcinoma, Spindle-Cell

HIF1A KYAT1 MET BRCA1

3.51e-031631124C0205697
DiseaseUndifferentiated carcinoma

HIF1A KYAT1 MET BRCA1

3.51e-031631124C0205698

Protein segments in the cluster

PeptideGeneStartEntry
QIPSFSNHCGTQEQE

TDG

391

Q13569
NVHTSLSHVQNGAPF

ZNF280B

221

Q86YH2
QIHHYPNGIVTVNCA

TGFBI

201

Q15582
IFQEHPLHGCSASNS

SLC4A2

846

P04920
HSPNCPFVKGEHTQN

BIRC6

351

Q9NR09
SHHPRSAGQNCTFQL

CSMD2

16

Q7Z408
TGHPVLTCQHGTNRN

CSMD2

2156

Q7Z408
QNPCHSSTHCLNNVG

ADGRE2

171

Q9UHX3
PNVSALHCQHLGNVA

ADGRA2

736

Q96PE1
EGHAQNVSCASFHPE

COPB2

226

P35606
CHSQDFSVHGNIING

CPXM1

551

Q96SM3
SHAVCNAQHDLPLSN

GKAP1

86

Q5VSY0
HFQCPHNSSNNANVT

CD79A

51

P11912
GHCHPLVVQAAHEQN

PHYKPL

61

Q8IUZ5
HCVDRHPNQQHVVAT

NUP43

221

Q8NFH3
PGSHQHSEQQQVCVT

REC114

181

Q7Z4M0
NNLTVPQGHAGCHTS

PCDH17

821

O14917
IQECKHPSVFQHGDN

MCOLN1

281

Q9GZU1
DQAVPLHLACQQGHF

ANKRD27

776

Q96NW4
ATGVDAICTHHLNPQ

MUC16

13076

Q8WXI7
PHHCNVTYNVNNGIQ

LDLRAD3

226

Q86YD5
DSHAGQQFHALEQPC

GLI3

1136

P10071
SPVHALHFCEGAQAQ

GNB1L

21

Q9BYB4
HITHQNGFQVCPHFV

METAP1D

236

Q6UB28
QPHVCFHGNCSNITS

EYS

261

Q5T1H1
FSQHAVVASHNGKPC

KCNJ10

181

P78508
QHTQVYQKEQCPAGH

NEIL2

281

Q969S2
SQVDGITGACHHTQP

RPGRIP1L

1131

Q68CZ1
FHHVQQSQGCIAVNF

JMJD7

276

P0C870
LNATHQHCVLAGSQP

FTO

301

Q9C0B1
GHIHVYDTNSNQPQC

HIF1A

196

Q16665
IHHNCTPEFQANEVR

IMPDH2

91

P12268
NCTGQNEHQRENSGH

MED7

196

O43513
LHSQPHQEENLCFEN

METTL25

296

Q8N6Q8
PAGALHQVQNFHSCI

JMJD1C

2461

Q15652
ANHVQCNTHPFDNEV

KDM5D

171

Q9BY66
DHVGCVNTVHFNQRG

DCAF8L2

226

P0C7V8
TCQGQICHNTVHLDP

FAT2

3731

Q9NYQ8
HVAPHCANFLVPSQN

LENG9

346

Q96B70
CQNNIIPHTFCEHIG

OR52B4

171

Q8NGK2
EQPSVCGSHTICNNH

NID1

716

P14543
TQHFAVCHVDAPGQQ

NDRG1

86

Q92597
QGQSTHVHDAQCENT

NFE2L2

411

Q16236
KTHQHHNPNEAEQCG

FAM214A

246

Q32MH5
VNLDPSHCSNNGTVH

MED15

691

Q96RN5
PGIQSHVHIENCDSS

LECT2

131

O14960
PSQAGNAFQEHTAHI

LAX1

131

Q8IWV1
PETSICQNCQHHTAG

LAMA2

1431

P24043
VCHTNTLNPAHGRQV

F8

1876

P00451
EVHSQFSTGHANSPC

MKI67

701

P46013
TLTCFEHNLQGNAHS

OSTM1

196

Q86WC4
NAQSQHCSPIQSHPS

PHC3

366

Q8NDX5
SQYSPAIEGHCNNIH

NCKAP1

1016

Q9Y2A7
HQVQQELSGTFAHLC

MFN2

686

O95140
IHHNCTPEFQANEVR

IMPDH1

91

P20839
CDEQGTLHGQPTYHQ

PASD1

711

Q8IV76
HTCVHPEVVGNFNRN

BRIP1

281

Q9BX63
VSNLHVEPCGTNTHA

BRCA1

266

P38398
THPSCNNEHVIVFNG

CUBN

2501

O60494
TLTAQGQQFHCHKAV

KLHL14

36

Q9P2G3
NQQLHFLHIGSCQDG

C6

826

P13671
HTLSHQDNFSPGQEV

CR1

1661

P17927
TFQKGSNAPCHSLQH

CPLANE1

3076

Q9H799
HQHICGQSAAVTVQA

DEAF1

536

O75398
LIHSQSNVQQNVCHG

FOXJ3

521

Q9UPW0
NHHVVNNTLEGNCSS

GNS

106

P15586
CHNANTNFVHSNSPV

MBD5

761

Q9P267
THQQCLNNGTCIPHF

CRB1

446

P82279
LNNGTCIPHFQDGQH

CRB1

451

P82279
QHFEAVHSGTPVTNN

SPACA9

81

Q96E40
NCGNTSVHHGAPLQL

RXYLT1

361

Q9Y2B1
QQSGNHPITVHCSAG

PTPRA

721

P18433
HFQHQSPTVPNCLST

HOXA2

286

O43364
SSHFPCSESQQHLNG

NR1D2

306

Q14995
CQRHVFPHNHTADIQ

MET

141

P08581
QNVHFHCSGAPVAPL

CAMK2B

651

Q13554
NHAVVCQGCHNAIDP

TES

356

Q9UGI8
QTEPCEGCEHQGQVH

SSPOP

1961

A2VEC9
CQRNDLNEEPQHFTH

NTN4

236

Q9HB63
PTQNIQHGHVGEESC

PHF7

146

Q9BWX1
FNISGHVNHPCTVEE

NDUFV1

276

P49821
TVHQNSVFHCPTQSQ

KYAT1

271

Q16773
TQCGVVPHQVFRNHL

SH2D5

336

Q6ZV89
SGTAIHNFPTVQHQE

PRRC2C

2486

Q9Y520
LHQASFPVETNCGHL

RNF170

91

Q96K19
KHFVVCHVDAPGQQV

NDRG4

61

Q9ULP0
CHVDAPGQQVGASQF

NDRG4

66

Q9ULP0
CHQFPHGITDQVIQN

POLR3F

26

Q9H1D9
HNCHNLPEGVADLTQ

SCRG1

36

O75711
AHHQFINNGNICTGD

PLPPR1

171

Q8TBJ4
SAVNQGHCHPKIVNA

OAT

86

P04181
GNISHFVNHSCDPNL

SUV39H1

316

O43463
HPEAQGTTQCQRTEH

SEMA5A

21

Q13591
QQPGFNCSSIPHSSH

TET1

826

Q8NFU7
QHEAAVQHPSSIIGC

B3GNTL1

126

Q67FW5
HQHSEKGLVDTPCFQ

C15orf62

121

A8K5M9
GSCPHSGDVHIQINS

RNFT1

71

Q5M7Z0
NADTIQHFCTQHGSP

TNFAIP2

556

Q03169
NNHQRTHTGEKPYQC

ZNF157

346

P51786
HPVTCSHFNQDLQPE

ZNF735

86

P0CB33
VSAVNTHGQAHCSAQ

SPEG

1136

Q15772
AQGCREHHSPQSHQQ

SPEM2

336

Q0P670
VPEGHDQVSCQAHVN

SRGAP2

651

O75044
PEQLNHAFHTCGVFS

TMEM50B

51

P56557
VPVHFNIQQDCGHFV

PRAG1

1041

Q86YV5
NIQQDCGHFVASVPS

PRAG1

1046

Q86YV5
HQRVHTGQKPFQCNE

ZNF33A

346

Q06730
HTNPIVENGQTHPCQ

TNPO3

621

Q9Y5L0
NAENNVPSCHHSQPA

ZGRF1

1341

Q86YA3
CYANPAVTEANGHIH

SLC39A8

256

Q9C0K1
HQRTHTGEKPYNCNQ

ZNF782

636

Q6ZMW2
VCHENSNPLENQHFI

ZBTB38

1161

Q8NAP3
SHASGLNHNPACESV

TTLL4

426

Q14679
QHDFSSQIFSLGHCP

TLE2

626

Q04725
TFCSGLIQHQQNHTD

ZNF850

711

A8MQ14
ECHQIFNQSPSFNEH

ZNF606

321

Q8WXB4
HQVVPPQSSFASCVH

ZAN

1756

Q9Y493
EFHPSANHTPCVENI

KCNJ1

111

P48048
NNFQHSVNVSCAHPE

LRIG2

461

O94898