Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR2 ITPR3	6.99e-06	3	31	2	GO:0005220
GeneOntologyMolecularFunction	pancreatic polypeptide receptor activity	NPY4R2 NPY4R	1.40e-05	4	31	2	GO:0001602
GeneOntologyMolecularFunction	L-lactate dehydrogenase activity	LDHA LDHB	2.33e-05	5	31	2	GO:0004459
GeneOntologyMolecularFunction	lactate dehydrogenase activity	LDHA LDHB	3.49e-05	6	31	2	GO:0004457
GeneOntologyMolecularFunction	neuropeptide Y receptor activity	NPY4R2 NPY4R	1.27e-04	11	31	2	GO:0004983
GeneOntologyMolecularFunction	inositol 1,4,5 trisphosphate binding	ITPR2 ITPR3	2.10e-04	14	31	2	GO:0070679
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	ITPR2 ITPR3	3.51e-04	18	31	2	GO:0015278
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	ITPR2 ITPR3	1.05e-03	31	31	2	GO:0099604
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	ITPR2 ITPR3	1.20e-03	33	31	2	GO:0005217
GeneOntologyMolecularFunction	neuropeptide binding	NPY4R2 NPY4R	1.50e-03	37	31	2	GO:0042923
GeneOntologyMolecularFunction	neuropeptide receptor activity	NPY4R2 NPY4R	3.06e-03	53	31	2	GO:0008188
GeneOntologyBiologicalProcess	lactate biosynthetic process from pyruvate	LDHA LDHB	1.31e-05	4	31	2	GO:0019244
GeneOntologyBiologicalProcess	lactate biosynthetic process	LDHA LDHB	4.57e-05	7	31	2	GO:0019249
GeneOntologyBiologicalProcess	lymphatic endothelial cell differentiation	ACVR2B TIE1	6.09e-05	8	31	2	GO:0060836
GeneOntologyCellularComponent	BRCA1-B complex	TOPBP1 BARD1	1.27e-05	4	31	2	GO:0070532
GeneOntologyCellularComponent	platelet dense tubular network membrane	ITPR2 ITPR3	7.61e-05	9	31	2	GO:0031095
GeneOntologyCellularComponent	platelet dense tubular network	ITPR2 ITPR3	1.16e-04	11	31	2	GO:0031094
Domain	Caskin-tail	CASKIN2 CASKIN1	2.49e-06	2	30	2	PF16632
Domain	Caskin_C	CASKIN2 CASKIN1	2.49e-06	2	30	2	IPR032117
Domain	NPY4_rcpt	NPY4R2 NPY4R	2.49e-06	2	30	2	IPR001933
Domain	SAM_1	CASKIN2 L3MBTL3 CASKIN1 L3MBTL4	4.10e-06	68	30	4	PF00536
Domain	InsP3_rcpt-bd	ITPR2 ITPR3	7.48e-06	3	30	2	IPR000493
Domain	SAM	CASKIN2 L3MBTL3 CASKIN1 L3MBTL4	1.15e-05	88	30	4	SM00454
Domain	SAM_DOMAIN	CASKIN2 L3MBTL3 CASKIN1 L3MBTL4	1.56e-05	95	30	4	PS50105
Domain	SAM	CASKIN2 L3MBTL3 CASKIN1 L3MBTL4	1.69e-05	97	30	4	IPR001660
Domain	-	CASKIN2 L3MBTL3 CASKIN1 L3MBTL4	2.40e-05	106	30	4	1.10.150.50
Domain	L-lactate_DH	LDHA LDHB	2.49e-05	5	30	2	IPR011304
Domain	L-lactate_DH_AS	LDHA LDHB	2.49e-05	5	30	2	IPR018177
Domain	L_LDH	LDHA LDHB	2.49e-05	5	30	2	PS00064
Domain	SAM/pointed	CASKIN2 L3MBTL3 CASKIN1 L3MBTL4	3.53e-05	117	30	4	IPR013761
Domain	RIH_assoc	ITPR2 ITPR3	3.73e-05	6	30	2	PF08454
Domain	RIH_assoc-dom	ITPR2 ITPR3	3.73e-05	6	30	2	IPR013662
Domain	RYDR_ITPR	ITPR2 ITPR3	3.73e-05	6	30	2	PF01365
Domain	RIH_dom	ITPR2 ITPR3	3.73e-05	6	30	2	IPR000699
Domain	Ins145_P3_rcpt	ITPR2 ITPR3	3.73e-05	6	30	2	IPR014821
Domain	Ryanodine_recept-rel	ITPR2 ITPR3	3.73e-05	6	30	2	IPR015925
Domain	Ins145_P3_rec	ITPR2 ITPR3	3.73e-05	6	30	2	PF08709
Domain	-	ITPR2 ITPR3	3.73e-05	6	30	2	1.25.10.30
Domain	ZF_CCHHC	L3MBTL3 L3MBTL4	5.21e-05	7	30	2	PS51802
Domain	Ldh_1_N	LDHA LDHB	6.94e-05	8	30	2	PF00056
Domain	L-lactate/malate_DH	LDHA LDHB	6.94e-05	8	30	2	IPR001557
Domain	Lactate/malate_DH_N	LDHA LDHB	6.94e-05	8	30	2	IPR001236
Domain	-	LDHA LDHB	8.92e-05	9	30	2	3.90.110.10
Domain	Lactate/malate_DH_C	LDHA LDHB	8.92e-05	9	30	2	IPR022383
Domain	Lactate_DH/Glyco_Ohase_4_C	LDHA LDHB	8.92e-05	9	30	2	IPR015955
Domain	MBT	L3MBTL3 L3MBTL4	8.92e-05	9	30	2	SM00561
Domain	Ldh_1_C	LDHA LDHB	8.92e-05	9	30	2	PF02866
Domain	MBT	L3MBTL3 L3MBTL4	8.92e-05	9	30	2	PS51079
Domain	NPY_rcpt	NPY4R2 NPY4R	8.92e-05	9	30	2	IPR000611
Domain	MIR	ITPR2 ITPR3	1.11e-04	10	30	2	PS50919
Domain	MIR	ITPR2 ITPR3	1.11e-04	10	30	2	PF02815
Domain	MIR	ITPR2 ITPR3	1.11e-04	10	30	2	SM00472
Domain	MBT	L3MBTL3 L3MBTL4	1.11e-04	10	30	2	PF02820
Domain	MIR_motif	ITPR2 ITPR3	1.11e-04	10	30	2	IPR016093
Domain	Mbt	L3MBTL3 L3MBTL4	1.11e-04	10	30	2	IPR004092
Domain	Ank_2	BARD1 CASKIN2 CASKIN1 ANKRD53	3.70e-04	215	30	4	PF12796
Domain	BRCT	TOPBP1 BARD1	4.19e-04	19	30	2	PF00533
Domain	Ank	BARD1 CASKIN2 CASKIN1 ANKRD53	4.62e-04	228	30	4	PF00023
Domain	BRCT	TOPBP1 BARD1	5.65e-04	22	30	2	SM00292
Domain	-	TOPBP1 BARD1	6.18e-04	23	30	2	3.40.50.10190
Domain	-	BARD1 CASKIN2 CASKIN1 ANKRD53	6.34e-04	248	30	4	1.25.40.20
Domain	ANK	BARD1 CASKIN2 CASKIN1 ANKRD53	6.63e-04	251	30	4	SM00248
Domain	ANK_REPEAT	BARD1 CASKIN2 CASKIN1 ANKRD53	6.83e-04	253	30	4	PS50088
Domain	Ankyrin_rpt-contain_dom	BARD1 CASKIN2 CASKIN1 ANKRD53	6.93e-04	254	30	4	IPR020683
Domain	ANK_REP_REGION	BARD1 CASKIN2 CASKIN1 ANKRD53	6.93e-04	254	30	4	PS50297
Domain	Ankyrin_rpt	BARD1 CASKIN2 CASKIN1 ANKRD53	7.78e-04	262	30	4	IPR002110
Domain	BRCT	TOPBP1 BARD1	7.91e-04	26	30	2	PS50172
Domain	BRCT_dom	TOPBP1 BARD1	9.19e-04	28	30	2	IPR001357
Domain	SH3_2	CASKIN2 CASKIN1	8.38e-03	86	30	2	IPR011511
Domain	SH3_2	CASKIN2 CASKIN1	8.38e-03	86	30	2	PF07653
Domain	Ion_trans_dom	ITPR2 ITPR3	1.44e-02	114	30	2	IPR005821
Domain	Ion_trans	ITPR2 ITPR3	1.44e-02	114	30	2	PF00520
Domain	-	EPHX2 DAGLA	1.56e-02	119	30	2	3.40.50.1820
Domain	AB_hydrolase	EPHX2 DAGLA	1.56e-02	119	30	2	IPR029058
Domain	EGF	CELSR2 TIE1	1.74e-02	126	30	2	PF00008
Pathway	REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS	DAGLA ITPR2 ITPR3	7.42e-06	25	22	3	MM14511
Pathway	REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS	DAGLA ITPR2 ITPR3	9.42e-06	27	22	3	M12123
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY	ITPR2 ITPR3	2.32e-05	5	22	2	M49000
Pathway	KEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY	ITPR2 ITPR3	3.47e-05	6	22	2	M47960
Pathway	KEGG_MEDICUS_REFERENCE_BCR_PLCG_ITPR_SIGNALING_PATHWAY	ITPR2 ITPR3	8.31e-05	9	22	2	M47852
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR2 ITPR3	1.04e-04	10	22	2	M47661
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR2 ITPR3	1.27e-04	11	22	2	M49033
Pathway	REACTOME_CLEC7A_DECTIN_1_INDUCES_NFAT_ACTIVATION	ITPR2 ITPR3	1.27e-04	11	22	2	M27466
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY	ITPR2 ITPR3	1.79e-04	13	22	2	M47751
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR2 ITPR3	1.79e-04	13	22	2	M47656
Pathway	WP_LACTATE_SHUTTLE_IN_GLIAL_CELLS	LDHA LDHB	1.79e-04	13	22	2	M48056
Pathway	WP_KREBS_CYCLE_DISORDERS	LDHA LDHB	1.79e-04	13	22	2	M39769
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR2 ITPR3	1.79e-04	13	22	2	M47696
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	ITPR2 ITPR3	1.79e-04	13	22	2	MM14553
Pathway	KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	SYNJ2 ITPR2 ITPR3	2.15e-04	76	22	3	M9052
Pathway	REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS	ITPR2 ITPR3	2.75e-04	16	22	2	M26945
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR2 ITPR3	3.91e-04	19	22	2	M47760
Pathway	REACTOME_VEGFR2_MEDIATED_CELL_PROLIFERATION	ITPR2 ITPR3	3.91e-04	19	22	2	M27423
Pathway	KEGG_MEDICUS_REFERENCE_TCR_PLCG_ITPR_SIGNALING_PATHWAY	ITPR2 ITPR3	3.91e-04	19	22	2	M47733
Pathway	KEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY	ITPR2 ITPR3	4.34e-04	20	22	2	M47688
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY	ITPR2 ITPR3	4.80e-04	21	22	2	M47689
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR2 ITPR3	5.27e-04	22	22	2	M47690
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR2 ITPR3	5.27e-04	22	22	2	M47675
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR2 ITPR3	5.77e-04	23	22	2	M47676
Pathway	KEGG_MEDICUS_REFERENCE_GLYCOLYSIS	LDHA LDHB	6.82e-04	25	22	2	M47623
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ITPR2 ITPR3	7.97e-04	27	22	2	MM15053
Pathway	REACTOME_PLATELET_CALCIUM_HOMEOSTASIS	ITPR2 ITPR3	8.57e-04	28	22	2	M924
Pathway	PID_BARD1_PATHWAY	TOPBP1 BARD1	9.20e-04	29	22	2	M258
Pathway	REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION	ITPR2 ITPR3	1.12e-03	32	22	2	MM14983
Pathway	KEGG_PROPANOATE_METABOLISM	LDHA LDHB	1.19e-03	33	22	2	M4086
Pathway	KEGG_CYSTEINE_AND_METHIONINE_METABOLISM	LDHA LDHB	1.27e-03	34	22	2	M10911
Pathway	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	ITPR2 ITPR3	1.42e-03	36	22	2	M1315
Pathway	REACTOME_HDR_THROUGH_SINGLE_STRAND_ANNEALING_SSA	TOPBP1 BARD1	1.42e-03	36	22	2	MM15281
Pathway	WP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION	ITPR2 ITPR3	1.42e-03	36	22	2	M39831
Pathway	REACTOME_HDR_THROUGH_SINGLE_STRAND_ANNEALING_SSA	TOPBP1 BARD1	1.50e-03	37	22	2	M27568
Pathway	KEGG_PYRUVATE_METABOLISM	LDHA LDHB	1.75e-03	40	22	2	M7934
Pathway	REACTOME_DAG_AND_IP3_SIGNALING	ITPR2 ITPR3	1.84e-03	41	22	2	M512
Pathway	REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION	ITPR2 ITPR3	1.93e-03	42	22	2	M791
Pathway	REACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE	TOPBP1 BARD1	2.02e-03	43	22	2	M27588
Pathway	REACTOME_PYRUVATE_METABOLISM	LDHA LDHB	2.11e-03	44	22	2	MM15393
Pathway	WP_RENINANGIOTENSINALDOSTERONE_SYSTEM_RAAS	ITPR2 ITPR3	2.11e-03	44	22	2	M39845
Pathway	WP_GLYCOLYSIS_AND_GLUCONEOGENESIS	LDHA LDHB	2.21e-03	45	22	2	M39474
Pathway	SIG_CHEMOTAXIS	ITPR2 ITPR3	2.21e-03	45	22	2	M5193
Pathway	SIG_BCR_SIGNALING_PATHWAY	ITPR2 ITPR3	2.31e-03	46	22	2	M8626
Pathway	REACTOME_PYRUVATE_METABOLISM	LDHA LDHB	2.62e-03	49	22	2	M17157
Pathway	KEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY	ITPR2 ITPR3	2.72e-03	50	22	2	M47951
Pathway	WP_GLYCOLYSIS_AND_GLUCONEOGENESIS	LDHA LDHB	2.83e-03	51	22	2	MM15928
Pathway	REACTOME_DISEASES_OF_DNA_REPAIR	TOPBP1 BARD1	2.83e-03	51	22	2	M29854
Pathway	REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS	ITPR2 ITPR3	3.05e-03	53	22	2	MM15716
Pathway	REACTOME_ION_HOMEOSTASIS	ITPR2 ITPR3	3.17e-03	54	22	2	MM15202
Pathway	REACTOME_ION_HOMEOSTASIS	ITPR2 ITPR3	3.17e-03	54	22	2	M27460
Pathway	REACTOME_G_PROTEIN_MEDIATED_EVENTS	ITPR2 ITPR3	3.17e-03	54	22	2	M26911
Pathway	KEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY	ITPR2 ITPR3	3.28e-03	55	22	2	M47952
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	ITPR2 ITPR3	4.02e-03	61	22	2	MM15071
Pathway	REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS	DAGLA ITPR2 ITPR3	4.07e-03	210	22	3	MM15043
Pathway	KEGG_GLYCOLYSIS_GLUCONEOGENESIS	LDHA LDHB	4.15e-03	62	22	2	M11521
Pathway	REACTOME_CA2_PATHWAY	ITPR2 ITPR3	4.15e-03	62	22	2	M27321
Pathway	REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS	DAGLA ITPR2 ITPR3	4.46e-03	217	22	3	M18437
Pathway	KEGG_LONG_TERM_POTENTIATION	ITPR2 ITPR3	5.27e-03	70	22	2	M3115
Pathway	KEGG_LONG_TERM_DEPRESSION	ITPR2 ITPR3	5.27e-03	70	22	2	M8232
Pathway	REACTOME_HDR_THROUGH_HOMOLOGOUS_RECOMBINATION_HRR	TOPBP1 BARD1	5.27e-03	70	22	2	M27570
Pathway	REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT	TOPBP1 BARD1	5.56e-03	72	22	2	MM15381
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	ITPR2 ITPR3	5.56e-03	72	22	2	MM14631
Pathway	WP_DRAVET_SYNDROME_SCN1AA1783V_POINT_MUTATION_MODEL	LDHA LDHB	5.71e-03	73	22	2	MM16641
Pathway	WP_AFFECTED_PATHWAYS_IN_DUCHENNE_MUSCULAR_DYSTROPHY	ITPR2 ITPR3	5.87e-03	74	22	2	M48080
Pathway	WP_ALZHEIMERS_DISEASE	ITPR2 ITPR3	5.87e-03	74	22	2	MM15962
Pathway	REACTOME_PROCESSING_OF_DNA_DOUBLE_STRAND_BREAK_ENDS	TOPBP1 BARD1	6.02e-03	75	22	2	MM15299
Pathway	REACTOME_PLATELET_HOMEOSTASIS	ITPR2 ITPR3	6.18e-03	76	22	2	MM15051
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	ITPR2 ITPR3	6.50e-03	78	22	2	M1921
Pathway	WP_DNA_IRDAMAGE_AND_CELLULAR_RESPONSE_VIA_ATR	TOPBP1 BARD1	6.99e-03	81	22	2	M39490
Pathway	REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION	DAGLA ITPR2 ITPR3	7.14e-03	257	22	3	MM15454
Pathway	REACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS	ITPR2 ITPR3	7.16e-03	82	22	2	M27110
Pathway	REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION	DAGLA ITPR2 ITPR3	7.45e-03	261	22	3	M1077
Pathway	WP_CLEAR_CELL_RENAL_CELL_CARCINOMA_PATHWAYS	LDHA LDHB	7.85e-03	86	22	2	M39375
Pathway	REACTOME_PLATELET_HOMEOSTASIS	ITPR2 ITPR3	7.85e-03	86	22	2	M916
Pathway	REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS	ITPR2 ITPR3	7.85e-03	86	22	2	M601
Pathway	REACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION	ITPR2 ITPR3	7.85e-03	86	22	2	M27206
Pathway	KEGG_GAP_JUNCTION	ITPR2 ITPR3	8.57e-03	90	22	2	M4013
Pathway	REACTOME_OPIOID_SIGNALLING	ITPR2 ITPR3	8.57e-03	90	22	2	M6467
Pathway	WP_METABOLIC_EPILEPTIC_DISORDERS	LDHA LDHB	8.75e-03	91	22	2	M48079
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_PHOSPHORYLATION	TOPBP1 BARD1	8.94e-03	92	22	2	MM15338
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_PHOSPHORYLATION	TOPBP1 BARD1	8.94e-03	92	22	2	M27636
Pathway	REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT	TOPBP1 BARD1	9.32e-03	94	22	2	M1080
Pathway	REACTOME_FCGR3A_MEDIATED_IL10_SYNTHESIS	ITPR2 ITPR3	9.51e-03	95	22	2	M29842
Pathway	REACTOME_PROCESSING_OF_DNA_DOUBLE_STRAND_BREAK_ENDS	TOPBP1 BARD1	9.90e-03	97	22	2	M27590
Pathway	REACTOME_CLEC7A_DECTIN_1_SIGNALING	ITPR2 ITPR3	1.05e-02	100	22	2	M27467
Pathway	KEGG_GNRH_SIGNALING_PATHWAY	ITPR2 ITPR3	1.07e-02	101	22	2	M1979
Pathway	REACTOME_CARDIAC_CONDUCTION	ITPR2 ITPR3	1.11e-02	103	22	2	MM15196
Pathway	REACTOME_SIGNALING_BY_VEGF	ITPR2 ITPR3	1.17e-02	106	22	2	M27077
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	ITPR2 ITPR3	1.22e-02	108	22	2	M17034
Pathway	REACTOME_G_ALPHA_I_SIGNALLING_EVENTS	NPY4R ITPR2 ITPR3	1.23e-02	314	22	3	M600
Pubmed	Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons.	LDHA LDHB PLP1	2.24e-08	7	31	3	38587131
Pubmed	Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers.	PLP1 ITPR2 ITPR3	2.32e-07	14	31	3	34630045
Pubmed	Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis.	LDHA TIE1 LDHB	6.15e-07	19	31	3	11331305
Pubmed	Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.	ITPR2 ITPR3	7.69e-07	2	31	2	9065779
Pubmed	Lactate dehydrogenase as promising marker for prognosis of brain metastasis.	LDHA LDHB	7.69e-07	2	31	2	35794505
Pubmed	Association of an exonic LDHA polymorphism with altered respiratory response in probands at high risk for panic disorder.	LDHA LDHB	7.69e-07	2	31	2	12555229
Pubmed	Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.	ITPR2 ITPR3	7.69e-07	2	31	2	17496801
Pubmed	IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism.	ITPR2 ITPR3	7.69e-07	2	31	2	16195467
Pubmed	Association between serum lactate dehydrogenase and frailty among individuals with metabolic syndrome.	LDHA LDHB	7.69e-07	2	31	2	34478437
Pubmed	M-LDH serves as a regulatory subunit of the cytosolic substrate-channelling complex in vivo.	LDHA LDHB	7.69e-07	2	31	2	17572440
Pubmed	Differences and similarities in binding of pyruvate and L-lactate in the active site of M4 and H4 isoforms of human lactate dehydrogenase.	LDHA LDHB	7.69e-07	2	31	2	20951115
Pubmed	Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism.	LDHA LDHB	7.69e-07	2	31	2	30158244
Pubmed	Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.	ITPR2 ITPR3	7.69e-07	2	31	2	24901844
Pubmed	Expression of lactate dehydrogenase A and B isoforms in the mouse kidney.	LDHA LDHB	7.69e-07	2	31	2	33719570
Pubmed	Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.	ITPR2 ITPR3	7.69e-07	2	31	2	15632133
Pubmed	Identification of breast cancer-restricted antigens by antibody screening of SKBR3 cDNA library using a preselected patient's serum.	LDHA LDHB	7.69e-07	2	31	2	12160330
Pubmed	Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.	ITPR2 ITPR3	7.69e-07	2	31	2	33854148
Pubmed	Inositol (1,4,5)-trisphosphate receptor links to filamentous actin are important for generating local Ca2+ signals in pancreatic acinar cells.	ITPR2 ITPR3	7.69e-07	2	31	2	15713744
Pubmed	Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.	ITPR2 ITPR3	7.69e-07	2	31	2	19528657
Pubmed	Moderate grade hyperammonemia activates lactate dehydrogenase-4 and 6-phosphofructo-2-kinase to support increased lactate turnover in the brain slices.	LDHA LDHB	7.69e-07	2	31	2	23703029
Pubmed	LDHA and LDHB are dispensable for aerobic glycolysis in neuroblastoma cells while promoting their aggressiveness.	LDHA LDHB	7.69e-07	2	31	2	30610122
Pubmed	Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.	ITPR2 ITPR3	7.69e-07	2	31	2	8063813
Pubmed	Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.	ITPR2 ITPR3	7.69e-07	2	31	2	8081734
Pubmed	The novel role of LDHA/LDHB in the prognostic value and tumor-immune infiltration in clear cell renal cell carcinoma.	LDHA LDHB	7.69e-07	2	31	2	37547725
Pubmed	Serum lactic dehydrogenase strongly predicts survival in metastatic nasopharyngeal carcinoma treated with palliative chemotherapy.	LDHA LDHB	7.69e-07	2	31	2	23266049
Pubmed	Local regulation of fat metabolism in peripheral nerves.	LDHA LDHB PLP1	1.12e-06	23	31	3	14522948
Pubmed	Rescue of calcineurin Aα(-/-) mice reveals a novel role for the α isoform in the salivary gland.	ITPR2 ITPR3	2.31e-06	3	31	2	21435446
Pubmed	Excess exogenous pyruvate inhibits lactate dehydrogenase activity in live cells in an MCT1-dependent manner.	LDHA LDHB	2.31e-06	3	31	2	34022218
Pubmed	An Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism.	LDHA LDHB	2.31e-06	3	31	2	33406399
Pubmed	Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.	ITPR2 ITPR3	2.31e-06	3	31	2	31979185
Pubmed	Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.	ITPR2 ITPR3	2.31e-06	3	31	2	10874040
Pubmed	Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.	ITPR2 ITPR3	2.31e-06	3	31	2	9808793
Pubmed	Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.	ITPR2 ITPR3	2.31e-06	3	31	2	24904548
Pubmed	Increased serum lactate dehydrogenase isoenzymes in Ph-negative chronic myeloproliferative diseases: a metabolic adaptation?	LDHA LDHB	2.31e-06	3	31	2	17178662
Pubmed	Glycolysis drives STING signaling to facilitate dendritic cell antitumor function.	LDHA LDHB	2.31e-06	3	31	2	36821379
Pubmed	Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.	ITPR2 ITPR3	2.31e-06	3	31	2	20395455
Pubmed	Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.	ITPR2 ITPR3	2.31e-06	3	31	2	17327232
Pubmed	Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase.	LDHA LDHB	2.31e-06	3	31	2	11276087
Pubmed	Association between serum lactate dehydrogenase and 60-day mortality in Chinese Hakka patients with acute myeloid leukemia: A cohort study.	LDHA LDHB	2.31e-06	3	31	2	34708888
Pubmed	High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio.	LDHA LDHB	2.31e-06	3	31	2	21041631
Pubmed	Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.	ITPR2 ITPR3	2.31e-06	3	31	2	17437169
Pubmed	Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.	ITPR2 ITPR3	2.31e-06	3	31	2	16014380
Pubmed	Accelerated Lactate Dehydrogenase Activity Potentiates Osteoclastogenesis via NFATc1 Signaling.	LDHA LDHB	2.31e-06	3	31	2	27077737
Pubmed	Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.	ITPR2 ITPR3	2.31e-06	3	31	2	18194433
Pubmed	Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.	ITPR2 ITPR3	2.31e-06	3	31	2	17890015
Pubmed	Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.	ITPR2 ITPR3	2.31e-06	3	31	2	18547250
Pubmed	Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.	ITPR2 ITPR3	2.31e-06	3	31	2	36350267
Pubmed	IP3 receptors regulate vascular smooth muscle contractility and hypertension.	ITPR2 ITPR3	2.31e-06	3	31	2	27777977
Pubmed	The versatility and universality of calcium signalling.	ITPR2 ITPR3	2.31e-06	3	31	2	11413485
Pubmed	Diagnostic value of procalcitonin, C-reactive protein and lactate dehydrogenase in paediatric malignant solid tumour concurrent with infection and tumour progression.	LDHA LDHB	2.31e-06	3	31	2	30976022
Pubmed	Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.	ITPR2 ITPR3	2.31e-06	3	31	2	23983250
Pubmed	Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.	ITPR2 ITPR3	2.31e-06	3	31	2	9858485
Pubmed	Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.	ITPR2 ITPR3	2.31e-06	3	31	2	26009177
Pubmed	Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.	NPY4R2 NPY4R	2.31e-06	3	31	2	8643460
Pubmed	Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.	ITPR2 ITPR3	2.31e-06	3	31	2	17581770
Pubmed	Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.	CASKIN2 CASKIN1	2.31e-06	3	31	2	31727973
Pubmed	Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase.	LDHA LDHB	2.31e-06	3	31	2	32859627
Pubmed	Beta-agonists enhance the lactic dehydrogenase (LDH) expression in serum and ventricular myocytes of mice.	LDHA LDHB	2.31e-06	3	31	2	17853776
Pubmed	Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.	ITPR2 ITPR3	2.31e-06	3	31	2	20427533
Pubmed	Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.	ITPR2 ITPR3	2.31e-06	3	31	2	18241669
Pubmed	Aberrant FGFR Tyrosine Kinase Signaling Enhances the Warburg Effect by Reprogramming LDH Isoform Expression and Activity in Prostate Cancer.	LDHA LDHB	2.31e-06	3	31	2	29891507
Pubmed	Estrogen-related receptor alpha modulates lactate dehydrogenase activity in thyroid tumors.	LDHA LDHB	2.31e-06	3	31	2	23516535
Pubmed	CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein.	CASKIN2 CASKIN1	2.31e-06	3	31	2	12040031
Pubmed	Properties of human testis-specific lactate dehydrogenase expressed from Escherichia coli.	LDHA LDHB	2.31e-06	3	31	2	1996957
Pubmed	Developmental regulation of expression of the lactate dehydrogenase (LDH) multigene family during mouse spermatogenesis.	LDHA LDHB	2.31e-06	3	31	2	2401207
Pubmed	Receptor-activated single channels in intact human platelets.	ITPR2 ITPR3	2.31e-06	3	31	2	1693919
Pubmed	Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.	ITPR2 ITPR3	2.31e-06	3	31	2	19068129
Pubmed	Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.	ITPR2 ITPR3	2.31e-06	3	31	2	23955339
Pubmed	Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.	ITPR2 ITPR3	4.61e-06	4	31	2	25215520
Pubmed	Protective effect of glutathione in HIV-1 lytic peptide 1-induced cell death in human neuronal cells.	LDHA LDHB	4.61e-06	4	31	2	11582518
Pubmed	Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A.	LDHA LDHB	4.61e-06	4	31	2	23650363
Pubmed	Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor.	ITPR2 ITPR3	4.61e-06	4	31	2	17925404
Pubmed	Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B.	ITPR2 ITPR3	4.61e-06	4	31	2	21424589
Pubmed	IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway.	ITPR2 ITPR3	4.61e-06	4	31	2	28419336
Pubmed	IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis.	ITPR2 ITPR3	4.61e-06	4	31	2	26193638
Pubmed	Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.	NPY4R2 NPY4R	4.61e-06	4	31	2	7592911
Pubmed	Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.	ITPR2 ITPR3	4.61e-06	4	31	2	11163362
Pubmed	IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming.	ITPR2 ITPR3	4.61e-06	4	31	2	35494252
Pubmed	Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.	ITPR2 ITPR3	4.61e-06	4	31	2	28615414
Pubmed	Direct role of plasma membrane-expressed gp120/41 in toxicity to human astrocytes induced by HIV-1-infected macrophages.	LDHA LDHB	4.61e-06	4	31	2	11125887
Pubmed	Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: involvement of the Akt-mTOR signaling pathway.	LDHA LDHB	4.61e-06	4	31	2	25524555
Pubmed	Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes.	ITPR2 ITPR3	4.61e-06	4	31	2	10828023
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TOPBP1 SYNJ2 CASKIN2 L3MBTL3 DAGLA CASKIN1	6.42e-06	529	31	6	14621295
Pubmed	Proteomic analysis of oxidatively modified proteins induced by the mitochondrial toxin 3-nitropropionic acid in human astrocytes expressing the HIV protein tat.	LDHA LDHB	7.68e-06	5	31	2	15710247
Pubmed	InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences.	ITPR2 ITPR3	7.68e-06	5	31	2	21568942
Pubmed	Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY.	NPY4R2 NPY4R	7.68e-06	5	31	2	7493937
Pubmed	Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors.	ITPR2 ITPR3	7.68e-06	5	31	2	21436055
Pubmed	The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2.	LDHA LDHB	1.15e-05	6	31	2	22135324
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	ITPR2 ITPR3	1.15e-05	6	31	2	23463619
Pubmed	Sprouty2 regulates PI(4,5)P2/Ca2+ signaling and HIV-1 Gag release.	ITPR2 ITPR3	1.15e-05	6	31	2	21762810
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	ITPR2 ITPR3	1.15e-05	6	31	2	16844763
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	ITPR2 ITPR3	1.15e-05	6	31	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	ITPR2 ITPR3	1.15e-05	6	31	2	25966694
Pubmed	Evaluation of multiple serum markers in advanced melanoma.	LDHA LDHB	1.15e-05	6	31	2	21858537
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	ITPR2 ITPR3	1.61e-05	7	31	2	11860456
Pubmed	Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.	ITPR2 ITPR3	1.61e-05	7	31	2	22495310
Pubmed	The lactate dehydrogenase (LDH) isoenzyme spectrum enables optimally controlling T cell glycolysis and differentiation.	LDHA LDHB	2.15e-05	8	31	2	36961904
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	ITPR2 ITPR3	2.15e-05	8	31	2	19033399
Pubmed	The transcription factor Foxp1 regulates aerobic glycolysis in adipocytes and myocytes.	FOXP1 LDHA	2.15e-05	8	31	2	37150320
Pubmed	Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU.	ITPR2 ITPR3	2.76e-05	9	31	2	25737585
Interaction	ZNRF4 interactions	ACVR2B DAGLA ITPR2 ITPR3	1.80e-05	110	29	4	int:ZNRF4
Interaction	SAMD13 interactions	L3MBTL3 L3MBTL4	4.18e-05	7	29	2	int:SAMD13
Interaction	DHFR2 interactions	CLPTM1L GALNS LDHA ITPR2 ITPR3	5.25e-05	289	29	5	int:DHFR2
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR2 ITPR3	5.06e-06	3	24	2	297
GeneFamily	Sterile alpha motif domain containing	CASKIN2 L3MBTL3 CASKIN1 L3MBTL4	5.17e-06	88	24	4	760
GeneFamily	Ankyrin repeat domain containing\|BRCA1 B complex	TOPBP1 BARD1	1.01e-05	4	24	2	1335
GeneFamily	Sterile alpha motif domain containing\|MBT domain containing	L3MBTL3 L3MBTL4	6.05e-05	9	24	2	1263
GeneFamily	Ankyrin repeat domain containing	BARD1 CASKIN2 CASKIN1 ANKRD53	2.69e-04	242	24	4	403
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHX2 TIE1 ITPR3 ANKRD53	6.56e-06	176	31	4	27e6b3ae41068d6cfdda3d46da7df2a27567140e
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHX2 TIE1 ITPR3 ANKRD53	6.56e-06	176	31	4	d6a5470af9592f34a741265f2ea9651c05c3add3
ToppCell	10x3'2.3-week_12-13-Myeloid_macrophage-stroma-erythroid_macrophage\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	CELSR2 PLP1 DAGLA ANKRD53	7.01e-06	179	31	4	c17ae394b855f01f8ca1765c416fd8b34a96e60b
ToppCell	COVID_non-vent-Lymphocytic-T_cell-CD4+_T_cell_(ISG_high)\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	EPHX2 FOXP1 SYNJ2 LDHB	9.24e-06	192	31	4	35557254738844c27ffcd00f3287fbcc0a4d0f3b
ToppCell	normal_Pleural_Fluid-T/NK_cells-Naive_CD4+_T\|T/NK_cells / Location, Cell class and cell subclass	EPHX2 FOXP1 LDHA LDHB	1.00e-05	196	31	4	5958caed4172ca478a6d9112d50af9070c850b96
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4\|lymph-node_spleen / Manually curated celltypes from each tissue	EPHX2 FOXP1 LDHA LDHB	1.04e-05	198	31	4	2cbafcb03df3c9aca68371df500d18ab8dcc416c
ToppCell	severe-CD4+_T_naive\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	EPHX2 FOXP1 LDHA LDHB	1.09e-05	200	31	4	f74bdabadca8ad6dae1b6e6812c66325aac50db0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TOPBP1 BARD1 NKPD1	1.68e-04	155	31	3	969fc4c98a96bf2f436e8e63d4deb2183ef3b864
ToppCell	3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EPHX2 FBXO39 CELSR2	1.81e-04	159	31	3	22427ad4ad2e797e4664e7a7b0514094f22a18b2
ToppCell	facs-Kidney-nan-24m-Epithelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 GALNS LDHB	2.05e-04	166	31	3	fe87b444fc0ef6fc20c646c9d2c3c8ce916a70c0
ToppCell	mild_COVID-19_(asymptomatic)-CD4+_T_naive\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	EPHX2 FOXP1 LDHB	2.09e-04	167	31	3	78d264af390bd89942ffbb2991dc94f50756d4c9
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 SSC5D LDHB	2.09e-04	167	31	3	2184c2760b6142e62124a2454a552723e20d4f61
ToppCell	E16.5-samps-Epithelial-Alveolar_epithelial_precursor-Uncommitted_AE_cell\|E16.5-samps / Age Group, Lineage, Cell class and subclass	CELSR2 LDHB ANKRD53	2.20e-04	170	31	3	5a64e05c263df915085988d881808221e2c0f2e2
ToppCell	systemic_lupus_erythematosus-treated-Hematopoietic-Progen-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	EPHX2 NKPD1 LDHB	2.24e-04	171	31	3	61d622153b91702ef21b0efc7b9581e592b7ccea
ToppCell	systemic_lupus_erythematosus-treated-Hematopoietic-Progen\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	EPHX2 NKPD1 LDHB	2.24e-04	171	31	3	09b3fa120f63c411f8a0dd6bd230a9720ce83fb1
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SSC5D LDHB DAGLA	2.28e-04	172	31	3	e15ab284df6dd241d4481f98864b18c39d757b8c
ToppCell	droplet-Mammary_Gland-nan-3m-Endothelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 STARD8 TIE1	2.32e-04	173	31	3	fbc8ed566ea36c39c258dd6b3823c82f5d6eb17f
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	FOXP1 TIE1 CASKIN2	2.36e-04	174	31	3	b4f3f5334803e5903bc496decf923f2e44f7fa3c
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Lymphocytic-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 PLP1 DAGLA	2.36e-04	174	31	3	6987fe7959afce347282f632abc16d800ccab7c4
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXP1 TIE1 CASKIN2	2.40e-04	175	31	3	1c7725f917f3d6b9e0a31ede9524690f408a5ea1
ToppCell	wk_15-18-Epithelial-PNS-Schwann_precursor\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CELSR2 PLP1 CASKIN1	2.48e-04	177	31	3	5357359e6c2161a37f39a6b3b78449f5cbc327d1
ToppCell	3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Differentiating_glia\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CELSR2 PLP1 DAGLA	2.48e-04	177	31	3	0417460bdb012bc43d7254377fa53d79cdab3f34
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR2 LDHB PLP1	2.52e-04	178	31	3	ef490b45901b2e6dedb519540fa3ae4e4db3a9ba
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR2 L3MBTL3 PLP1	2.61e-04	180	31	3	da723df348d7b8449bb1124f23fe6fa706412adb
ToppCell	droplet-Heart-nan-3m-Neuronal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR2 L3MBTL3 PLP1	2.61e-04	180	31	3	5b146a94708b3c3610542a4d0925f3f7a2b19185
ToppCell	droplet-Heart-nan-3m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR2 L3MBTL3 PLP1	2.61e-04	180	31	3	50758b1e7be2e43f83c10ab106900c067e61f5f7
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CELSR2 PLP1 DAGLA	2.65e-04	181	31	3	a436e7e4c36403257ea90160a58ca0d6d7c0cdfc
ToppCell	facs-Kidney-nan-3m\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD8 TIE1 PLP1	2.69e-04	182	31	3	4c5d14e33ebdf117b5aa9e2f57aaa89aa51f72bf
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPHX2 FOXP1 LDHB	2.69e-04	182	31	3	9ba85f621a846531a2a7861e9df695d288c9e149
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TIE1 SYNJ2 CASKIN2	2.78e-04	184	31	3	16ed515fb673a9d6973133afcda0a3fba4a8d9dc
ToppCell	COVID-19_Convalescent-Lymphoid_T/NK-CD8+_T_naive\|COVID-19_Convalescent / Disease group, lineage and cell class	EPHX2 FOXP1 LDHB	2.78e-04	184	31	3	0299cd30a3ea8e861a9d529043c204048ae21d29
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPHX2 FOXP1 LDHB	2.78e-04	184	31	3	5350b58aa9979631228835d11eb45ddf81d08bff
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)	EPHX2 FOXP1 LDHB	2.82e-04	185	31	3	863a3d44c1f115942d7a2a2b63a92fe5fc768814
ToppCell	COVID-19_Convalescent-CD8+_T_naive\|COVID-19_Convalescent / Disease condition and Cell class	EPHX2 FOXP1 LDHB	2.82e-04	185	31	3	2f8277a0b58fb0c49fa76ff6dfa6da961da1f9f5
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPHX2 FOXP1 LDHB	2.82e-04	185	31	3	fcd95bc074e982fc7b8fd48d2e80038b9ea35ebb
ToppCell	remission-CD8+_T_naive\|World / disease stage, cell group and cell class	EPHX2 FOXP1 LDHB	2.82e-04	185	31	3	69304d7dd406ac7e96d51c239d7035a06d88704f
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EPHX2 FOXP1 LDHB	2.82e-04	185	31	3	27dbfcd40ec832d5cf757331d8af3b5176ae90fb
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	EPHX2 FOXP1 LDHB	2.82e-04	185	31	3	1c23891e4d75f99296d1304af7a9d6c3cb28d04c
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	EPHX2 FOXP1 ITPR2	2.82e-04	185	31	3	1d874608aa2062024323512f68889219471b2f00
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EPHX2 FOXP1 LDHB	2.82e-04	185	31	3	ca8e921a6b45cd39474b9f86c95e7be023585c5d
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXP1 LDHA TIE1	2.87e-04	186	31	3	a58c9d1567da0961e0e295a156773d2252ee5a1a
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4-Tnaive/CM_CD4\|Lung / Manually curated celltypes from each tissue	EPHX2 FOXP1 SYNJ2	2.87e-04	186	31	3	c67f373ba60e8d1ab70dfacc711ee440eaff6fb3
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	EPHX2 FOXP1 ITPR2	2.92e-04	187	31	3	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	P03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FOXP1 TIE1 ITPR3	2.92e-04	187	31	3	66ebe1788d51b3e17bec6cdb219f709756b4e530
ToppCell	droplet-Marrow-nan-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TOPBP1 GALNS LDHB	2.92e-04	187	31	3	14c239af77116d28d511dea754b6150d20488080
ToppCell	Primary_Motor_Cortex_(M1)\|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LDHA LDHB PLP1	2.92e-04	187	31	3	892a4d439a0aa90f254dd17e1edce1fdc3619510
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPHX2 FOXP1 LDHB	2.96e-04	188	31	3	2b630b0609d4ac61338d6533cb7893cfe1241e44
ToppCell	(1)_T_CD4_naive\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	EPHX2 FOXP1 LDHB	2.96e-04	188	31	3	b8f67ac2faadd5b848955e43ab5d6cf5e49b3681
ToppCell	facs-Lung\|facs / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FOXP1 TIE1 CASKIN2	2.96e-04	188	31	3	f7292fc8e914f222828dcdb0a017d716207a97f6
ToppCell	droplet-Limb_Muscle-nan-18m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LDHB PLP1 CASKIN1	2.96e-04	188	31	3	8385fd384fc55e3b17802bb6698eb93b2c16d7f2
ToppCell	mild_COVID-19-CD8+_T_naive\|mild_COVID-19 / disease group, cell group and cell class (v2)	EPHX2 FOXP1 LDHB	2.96e-04	188	31	3	60d27014e5f9e562efe2a602482ea1d07efd0331
ToppCell	tumor_Lymph_Node_/_Brain-Fibroblasts-Undetermined\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	ZNF219 SYNJ2 L3MBTL3	2.96e-04	188	31	3	8231e635706a296db6b6da1029a33bbc1b52478e
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 LDHB PLP1	2.96e-04	188	31	3	c1f64311ff05093b2f4f672e33f5f75e3bc8a8db
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHX2 LDHB PLP1	2.96e-04	188	31	3	c2febf9fd4632af1f922067c3a30e5c50f75f480
ToppCell	mild_COVID-19-CD8+_T_naive\|World / disease group, cell group and cell class (v2)	EPHX2 FOXP1 LDHB	2.96e-04	188	31	3	ddfb1c64305825fb0bc23819aa001bfc2ac4c2b2
ToppCell	facs-Lung\|facs / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FOXP1 TIE1 CASKIN2	2.96e-04	188	31	3	e2b6e14579ec649a2bc106d9c99bb78ceb16ede3
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STARD8 TIE1 CASKIN2	2.96e-04	188	31	3	5d166d9e71632edd059ff0a9f66f8763f259d40a
ToppCell	droplet-Limb_Muscle-nan-18m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LDHB PLP1 CASKIN1	2.96e-04	188	31	3	cb9d0b48e2fd9cc576132803273b9c0382900944
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_collecting_duct_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 LDHB PLP1	2.96e-04	188	31	3	b483b4629695764568bcbd1d527d614824147783
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SSC5D PLP1 L3MBTL4	3.01e-04	189	31	3	da9ecc0d7b81c1901f30f97bb44112dc85444a66
ToppCell	RA-10._Endothelium_II\|RA / Chamber and Cluster_Paper	FOXP1 TIE1 ITPR2	3.01e-04	189	31	3	c81787a8c662db5d7814c583dd64562857629e81
ToppCell	droplet-Heart-nan-24m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 FOXP1 TIE1	3.01e-04	189	31	3	1137583e21d874c201c20581ba1995e2bfa3de59
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPHX2 FOXP1 LDHB	3.01e-04	189	31	3	8130102c41b2978a8b83f765ce383f836a464795
ToppCell	droplet-Heart-nan-18m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CELSR2 L3MBTL3 PLP1	3.01e-04	189	31	3	0493f7b79127c207fd7ade778ef4810500495d7e
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	FOXP1 TIE1 CASKIN2	3.05e-04	190	31	3	5130fb325f80f591b9b36beacb8072c4472304f2
ToppCell	droplet-Heart-nan-24m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 FOXP1 TIE1	3.05e-04	190	31	3	7068754c29f63a331e2b6c54715f3b26f37ad32b
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXP1 TIE1 ITPR3	3.05e-04	190	31	3	d87b9e9ca863270a9c7f61674271a6440c97d1f4
ToppCell	PND01-03-samps-Endothelial\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	FOXP1 TIE1 CASKIN2	3.05e-04	190	31	3	1357bd4527399d7013ee33272bda7453f472999a
ToppCell	droplet-Limb_Muscle-nan-18m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LDHB PLP1 CASKIN1	3.05e-04	190	31	3	e2481bd5166fde2cdc0c3824894f2bccb8294fdd
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD8 TIE1 LDHB	3.10e-04	191	31	3	88f91e57a1409bdeb91e9bf47510a6fb998a1bf5
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-Undetermined\|Myeloid_cells / Location, Cell class and cell subclass	FOXP1 TIE1 LDHB	3.10e-04	191	31	3	781f6005673fc3504a85801a68af3e16ca84952f
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD4+_T-CD4+_T_naive-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	EPHX2 FOXP1 LDHB	3.10e-04	191	31	3	f398344aaa79fc93d792e241b634a6afe4aff33d
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD4+_T-CD4+_T_naive\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EPHX2 FOXP1 LDHB	3.10e-04	191	31	3	11da47d96f44ba629e3299667495e7daddbbe86c
ToppCell	severe_COVID-19-CD4+_T_naive\|World / disease group, cell group and cell class (v2)	EPHX2 FOXP1 LDHB	3.10e-04	191	31	3	55a282478488efd1561ea57a6f0218f55f711bb0
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPHX2 FOXP1 LDHB	3.10e-04	191	31	3	d9a6f61fcda4f5352488f7f55cb9b57aeacc717f
ToppCell	facs-Heart-RV-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 FOXP1 TIE1	3.10e-04	191	31	3	e518c598719119e60c76016c586b1520c258bbcb
ToppCell	COVID-19_Moderate-CD8+_T_naive\|World / disease group, cell group and cell class	EPHX2 FOXP1 LDHB	3.10e-04	191	31	3	c3385226915097f47d2f197166fc755227438524
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD4+_T-CD4+_T_naive\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	EPHX2 FOXP1 LDHB	3.10e-04	191	31	3	ffcb2c8dbcf40281b439f4b719b5b341972ffb9a
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STARD8 TIE1 LDHB	3.10e-04	191	31	3	1924af7d8b0a0b892e480a9fd6d874941b0c0b5d
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPHX2 FOXP1 LDHB	3.10e-04	191	31	3	fda432a7f79664e8ffd5d03c1c69ec43bbac994b
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD4+_T-CD4+_T_naive-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EPHX2 FOXP1 LDHB	3.10e-04	191	31	3	ffe88d1ad676c745c76db89f766062fd365329f4
ToppCell	facs-Heart-RV-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX2 FOXP1 TIE1	3.10e-04	191	31	3	f0c649bb32732c9dd38a0af8ce94d2a4d16de39a
ToppCell	Leuk-UTI-Lymphocyte-T_NK-CD4_Naive\|Leuk-UTI / Disease, Lineage and Cell Type	EPHX2 FOXP1 LDHB	3.15e-04	192	31	3	ecdcb210a448495fc141ddc946cca1fbd821ad83
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	EPHX2 FOXP1 LDHB	3.15e-04	192	31	3	284955fec5103194d416320f41fa4d87c7efc4fb
ToppCell	remission-CD4+_T_naive\|World / disease stage, cell group and cell class	EPHX2 FOXP1 LDHB	3.15e-04	192	31	3	4bd94ce876d70f93dbdfad1dcd09e1468213cf57
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPHX2 FOXP1 LDHB	3.15e-04	192	31	3	32927ef3b93e0497e9bbe63c2754da03cf178202
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EPHX2 FOXP1 LDHB	3.15e-04	192	31	3	0d3b2b9cd586a4adbc3755563dd50b140227c287
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPHX2 FOXP1 LDHB	3.15e-04	192	31	3	ef8970e5389bd55c1624cd6dd01a7ca7abaa8950
ToppCell	COVID-19_Convalescent-Lymphoid_T/NK-CD4+_T_naive\|COVID-19_Convalescent / Disease group, lineage and cell class	EPHX2 FOXP1 LDHB	3.15e-04	192	31	3	ad7207810116e73d461242e42071901b6a9f48c6
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	EPHX2 FOXP1 LDHB	3.15e-04	192	31	3	ad2e0f35d50fe4e6977eba8a7a2bd990f6946305
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c05-FOS\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPHX2 FOXP1 LDHB	3.15e-04	192	31	3	78546a6e077076834fd717607610ab6df3b6e7ba
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EPHX2 FOXP1 LDHB	3.15e-04	192	31	3	67f50e5b1d449923002dc5b5d0c4d32c523034d3
ToppCell	remission-CD4+_T_naive\|remission / disease stage, cell group and cell class	EPHX2 FOXP1 LDHB	3.15e-04	192	31	3	d96b2122e28c735d8002ad6eb2d3d52c8e9ccf2b
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FOXP1 TIE1 CASKIN2	3.15e-04	192	31	3	517bc24b9ad5e2b5a3609ca55d7327c4700db9db
ToppCell	mild_COVID-19-CD4+_T_naive\|World / disease group, cell group and cell class (v2)	EPHX2 FOXP1 LDHB	3.20e-04	193	31	3	42ddacc55658ea6ba4248ac19c9c3709f342b4f5
ToppCell	tumor_Lymph_Node_/_Brain-T/NK_cells-Naive_CD4+_T\|T/NK_cells / Location, Cell class and cell subclass	EPHX2 FOXP1 LDHB	3.20e-04	193	31	3	1778342a7f546dbc8c1f7875aa505345e72ee765
ToppCell	droplet-Thymus-nan-18m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF219 LDHB WDR33	3.20e-04	193	31	3	81871f4f2b63ca5f64a9ff12f6c909a34bf52216
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPHX2 FOXP1 LDHB	3.20e-04	193	31	3	d169fdc704c66f26d53457f4de3a22de0811e240
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EPHX2 FOXP1 LDHB	3.20e-04	193	31	3	6436d3bfce02d137b76e5c4c8b2fe27974c57c99
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPHX2 FOXP1 LDHB	3.20e-04	193	31	3	95f5611dd9583f339b7c9f52bb478af204fb89ad
Drug	Oxamic Acid	LDHA LDHB	1.68e-06	2	30	2	DB03940
Drug	adenophostin A	ITPR2 ITPR3	1.68e-06	2	30	2	ctd:C085029
Drug	glycerol;phosphate	GALNS LDHA LDHB PLP1	3.43e-06	79	30	4	CID000082875
Drug	Sulmazole [73384-60-8]; Down 200; 14uM; HL60; HT_HG-U133A	ZNF219 CELSR2 SYNJ2 WDR33 ITPR2	5.24e-06	195	30	5	2153_DN
Drug	copper(II) sulfate pentahydrate; Up 200; 100uM; MCF7; HG-U133A	ZNF219 SYNJ2 CASKIN2 DAGLA ITPR3	5.51e-06	197	30	5	438_UP
Drug	ox-Q	LDHA LDHB	1.01e-05	4	30	2	CID000448650
Drug	AC1Q6L57	GALNS LDHA LDHB	1.20e-05	34	30	3	CID000090740
Drug	spirobishexahydropyrimidine	LDHA LDHB	1.67e-05	5	30	2	CID000100750
Drug	AC1O5TJF	LDHA LDHB	1.67e-05	5	30	2	CID006440410
Drug	1,4-diethoxybutane	LDHA LDHB	1.67e-05	5	30	2	CID000232578
Drug	C4H3NO4	LDHA LDHB	1.67e-05	5	30	2	CID000448651
Drug	S-lac-NAD	LDHA LDHB	1.67e-05	5	30	2	CID000194292
Drug	sorbarin	LDHA LDHB	1.67e-05	5	30	2	CID009824100
Drug	acetylphosphonic acid	LDHA LDHB	1.67e-05	5	30	2	CID000081311
Drug	NSC-60195	LDHA LDHB	1.67e-05	5	30	2	CID000020481
Drug	ethyl gossypol	LDHA LDHB	1.67e-05	5	30	2	CID000374353
Drug	AC1O5ZB9	LDHA LDHB	1.67e-05	5	30	2	CID006443605
Drug	AC1L49DG	LDHA LDHB	1.67e-05	5	30	2	CID000152931
Drug	oxyayanin A	LDHA LDHB	1.67e-05	5	30	2	CID005281676
Drug	B-HAD	LDHA LDHB	1.67e-05	5	30	2	CID000131338
Drug	SQ 31,486	LDHA LDHB	1.67e-05	5	30	2	CID000130015
Drug	N-trifluoroacetyl-glycine	LDHA LDHB	1.67e-05	5	30	2	CID000136227
Drug	BMS-188107	LDHA LDHB	1.67e-05	5	30	2	CID000192297
Drug	guanidine hydrochloride	GALNS LDHA LDHB PLP1	2.40e-05	129	30	4	CID000005742
Drug	AC1L24G8	LDHA LDHB	2.51e-05	6	30	2	CID000066023
Drug	BL-443	LDHA LDHB	2.51e-05	6	30	2	CID000054436
Drug	oxymethacil	LDHA LDHB	2.51e-05	6	30	2	CID000096369
Drug	dansyl-L-lysine	LDHA LDHB	2.51e-05	6	30	2	CID000598797
Drug	I 65	LDHA LDHB	2.51e-05	6	30	2	CID000149068
Drug	D 701	LDHA LDHB	2.51e-05	6	30	2	CID003051460
Drug	2,3-dihydroxy-1-naphthoic acid	LDHA LDHB	2.51e-05	6	30	2	CID000028002
Drug	SQ 32,926	LDHA LDHB	2.51e-05	6	30	2	CID000131363
Drug	hydroxypyruvate	GALNS LDHA LDHB	3.02e-05	46	30	3	CID000000964
Drug	N-acetyl-9-O-lactylneuraminic acid	LDHA LDHB	3.51e-05	7	30	2	CID000191486
Drug	sodium glycolate	LDHA LDHB	3.51e-05	7	30	2	CID000517347
Drug	AC1O7170	LDHA LDHB	3.51e-05	7	30	2	CID006540699
Drug	AC1NSM0G	LDHA LDHB	3.51e-05	7	30	2	CID005365671
Drug	BS35	LDHA LDHB	3.51e-05	7	30	2	CID000029316
Drug	BS36	LDHA LDHB	3.51e-05	7	30	2	CID000029308
Drug	pentabromoacetone	LDHA LDHB	3.51e-05	7	30	2	CID000065579
Drug	methyl-4-hydroxy-3-nitrobenzimidate	LDHA LDHB	3.51e-05	7	30	2	CID005492576
Drug	gossylic iminolactone	LDHA LDHB	3.51e-05	7	30	2	CID005479302
Drug	U75412E	LDHA LDHB	4.68e-05	8	30	2	CID003035460
Drug	AC1Q3O0A	LDHA LDHB	4.68e-05	8	30	2	CID000060880
Drug	UR-12633	LDHA LDHB	4.68e-05	8	30	2	CID000128030
Drug	p-(phenoxypropoxy)aniline	LDHA LDHB	4.68e-05	8	30	2	CID000423258
Drug	2-methyl-2-pentenoate	LDHA LDHB	4.68e-05	8	30	2	CID000018458
Drug	BS37	LDHA LDHB	4.68e-05	8	30	2	CID000027925
Drug	AC1L4GHU	LDHA LDHB	4.68e-05	8	30	2	CID000156607
Drug	N-dodecyl morpholine	LDHA LDHB	4.68e-05	8	30	2	CID000073764
Drug	S-(2-chloroethyl)-L-cysteine	LDHA LDHB	4.68e-05	8	30	2	CID000034229
Drug	BNPS-skatole	LDHA LDHB PLP1	4.89e-05	54	30	3	CID000094388
Drug	2,4,4'-trichlorobiphenyl	TOPBP1 BARD1 FOXP1 GALNS ACVR2B CELSR2 TIE1 NPY4R L3MBTL4	5.73e-05	1411	30	9	ctd:C081766
Drug	benzamyl	LDHA LDHB	6.01e-05	9	30	2	CID000160884
Drug	Bcdfg	LDHA LDHB	6.01e-05	9	30	2	CID003036106
Drug	N-acetyl-ala-ala-ala-methyl ester	LDHA LDHB	6.01e-05	9	30	2	CID000100120
Drug	2,4,5,2',5'-pentachlorobiphenyl	TOPBP1 BARD1 FOXP1 GALNS ACVR2B CELSR2 TIE1 NPY4R L3MBTL4	6.75e-05	1441	30	9	ctd:C009828
Drug	FK3311	LDHA LDHB	7.50e-05	10	30	2	CID000164009
Drug	2-keto-4-mercaptobutyric acid	LDHA LDHB	7.50e-05	10	30	2	CID000151198
Drug	hydroxyisonobilin	LDHA LDHB	7.50e-05	10	30	2	CID006438562
Drug	bis-NAD	LDHA LDHB	7.50e-05	10	30	2	CID003081557
Drug	pyridinophane cryptand	LDHA LDHB	7.50e-05	10	30	2	CID006454246
Drug	sodium oxamate	LDHA LDHB	7.50e-05	10	30	2	CID000005242
Drug	mivazerol	LDHA LDHB	7.50e-05	10	30	2	CID000060783
Drug	phosphoenolthiopyruvate	LDHA LDHB	7.50e-05	10	30	2	CID000194910
Drug	allyl alcohol	GALNS LDHA LDHB	8.15e-05	64	30	3	CID000007858
Drug	AC1O54Y4	ACVR2B LDHA LDHB	8.53e-05	65	30	3	CID006452212
Drug	octanoate	GALNS LDHA LDHB CASKIN1	9.01e-05	181	30	4	CID000000379
Drug	fullerene C60	ZNF219 FBXO39 STARD8 TIE1 CASKIN2 LDHB PLP1 DAGLA ITPR3	9.11e-05	1498	30	9	ctd:C069837
Drug	5-ethylphenazin-5-ium	LDHA LDHB	9.16e-05	11	30	2	CID000082689
Drug	hydrazinium nitrate	LDHA LDHB	9.16e-05	11	30	2	CID000166817
Drug	hexandiol	LDHA LDHB	9.16e-05	11	30	2	CID000147023
Drug	polyvinylpyridine-N-oxide	LDHA LDHB	9.16e-05	11	30	2	CID000024772
Drug	AC1O748K	EPHX2 LDHA LDHB	1.02e-04	69	30	3	CID006518413
Drug	2-bromoethanol	NKPD1 GALNS	1.10e-04	12	30	2	CID000010898
Drug	LG61	LDHA LDHB	1.10e-04	12	30	2	CID000520177
Drug	U74500A	LDHA LDHB	1.10e-04	12	30	2	CID000107964
Drug	creatine	ZMPSTE24 LDHA LDHB PLP1	1.15e-04	193	30	4	CID000000586
Drug	Flutamide [13311-84-7]; Down 200; 14.4uM; MCF7; HT_HG-U133A	EPHX2 ZNF219 SYNJ2 WDR33	1.25e-04	197	30	4	3885_DN
Drug	Cefotiam hydrochloride; Down 200; 7.2uM; HL60; HT_HG-U133A	ZNF219 CELSR2 NPY4R ITPR2	1.27e-04	198	30	4	2458_DN
Drug	Ketoprofen [22071-15-4]; Down 200; 15.8uM; MCF7; HT_HG-U133A	EPHX2 NPY4R SYNJ2 DAGLA	1.27e-04	198	30	4	3626_DN
Drug	Diprophylline [479-18-5]; Down 200; 15.8uM; HL60; HT_HG-U133A	GALNS SYNJ2 WDR33 ITPR2	1.27e-04	198	30	4	1853_DN
Drug	diphenaldehyde	LDHA LDHB	1.30e-04	13	30	2	CID000014585
Drug	II 13	LDHA LDHB	1.30e-04	13	30	2	CID003040488
Drug	3-mercaptolactic acid	LDHA LDHB	1.30e-04	13	30	2	CID000160645
Drug	2-oxohexanoate	LDHA LDHB	1.30e-04	13	30	2	CID000159664
Drug	T 514	LDHA LDHB	1.30e-04	13	30	2	CID000114820
Drug	Corticosterone [50-22-6]; Down 200; 11.6uM; PC3; HT_HG-U133A	ZNF219 CELSR2 SYNJ2 ITPR2	1.30e-04	199	30	4	4064_DN
Drug	Iopanoic acid [96-83-3]; Up 200; 7uM; MCF7; HT_HG-U133A	SYNJ2 PLP1 ITPR2 ITPR3	1.30e-04	199	30	4	5448_UP
Drug	SB 202190; Up 200; 1uM; PC3; HT_HG-U133A	ZNF219 GALNS SYNJ2 CASKIN2	1.30e-04	199	30	4	7058_UP
Drug	Proxyphylline [603-00-9]; Up 200; 16.8uM; PC3; HT_HG-U133A	EPHX2 CELSR2 SYNJ2 DAGLA	1.30e-04	199	30	4	7290_UP
Drug	nisoldipine	LDHA LDHB ITPR3	1.47e-04	78	30	3	CID000004499
Drug	beryllium nitrate	LDHA LDHB	1.51e-04	14	30	2	CID000026126
Drug	scymnol	LDHA LDHB	1.51e-04	14	30	2	CID000165531
Drug	AC1L3P2T	LDHA LDHB	1.51e-04	14	30	2	CID000119585
Drug	2-bromohydroquinone	LDHA LDHB	1.74e-04	15	30	2	CID000068502
Drug	ethion	LDHA LDHB	1.74e-04	15	30	2	CID000003286
Drug	methyl palmitate	GALNS PLP1	1.74e-04	15	30	2	CID000008181
Drug	Ac-YVAD-Amc	LDHA LDHB	1.74e-04	15	30	2	CID000004337
Drug	potassium citrate	LDHA LDHB	1.99e-04	16	30	2	CID000013344
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR2 ITPR3	6.55e-05	12	30	2	DOID:1441 (implicated_via_orthology)
Disease	Mammary Carcinoma, Human	BARD1 STARD8 SYNJ2 L3MBTL3 LDHB	1.73e-04	525	30	5	C4704874
Disease	Mammary Neoplasms, Human	BARD1 STARD8 SYNJ2 L3MBTL3 LDHB	1.73e-04	525	30	5	C1257931
Disease	Mammary Neoplasms	BARD1 STARD8 SYNJ2 L3MBTL3 LDHB	1.76e-04	527	30	5	C1458155
Disease	Breast Carcinoma	BARD1 STARD8 SYNJ2 L3MBTL3 LDHB	1.93e-04	538	30	5	C0678222
Disease	disease of metabolism (implicated_via_orthology)	LDHA LDHB	2.07e-04	21	30	2	DOID:0014667 (implicated_via_orthology)
Disease	brain cancer (implicated_via_orthology)	L3MBTL3 L3MBTL4	3.20e-04	26	30	2	DOID:1319 (implicated_via_orthology)
Disease	phosphatidylcholine 38:4 measurement	DAGLA ITPR2	3.72e-04	28	30	2	EFO_0010386
Disease	Malignant neoplasm of breast	BARD1 CLPTM1L STARD8 SYNJ2 L3MBTL3 LDHB	6.43e-04	1074	30	6	C0006142
Disease	lung adenocarcinoma	EPHX2 CLPTM1L SSC5D	7.28e-04	174	30	3	EFO_0000571
Disease	human papilloma virus infection, oral cavity cancer	CLPTM1L LDHA	8.39e-04	42	30	2	EFO_0001668, EFO_0005570
Disease	age at initiation of smoking	EPHX2 ITPR3	2.06e-03	66	30	2	EFO_0021784
Disease	metabolite measurement	EPHX2 FOXP1 FBXO39 ITPR2	2.38e-03	560	30	4	EFO_0004725
Disease	lung cancer (is_implicated_in)	CLPTM1L DAGLA	2.58e-03	74	30	2	DOID:1324 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
GWTPLHEACNHGHLK	BARD1	461	Q99728
WPVLHHLHGCRGCGA	ARMC5	801	Q96C12
GHLVPHHDGLRVWCP	CELSR2	81	Q9HCU4
HHDGLRVWCPESEAH	CELSR2	86	Q9HCU4
LWEIEVVHHDPCRGG	ITPR2	281	Q14571
EVVHHDPCRGGAGHW	ITPR3	286	Q14573
ERLGVHPLSCHGWVL	LDHA	176	P00338
HPLSCHGWVLGEHGD	LDHA	181	P00338
IHPVGWCEKTGHKLH	L3MBTL3	316	Q96JM7
PHIHPVGWCKEHRRT	L3MBTL3	421	Q96JM7
AIRKWLHGKLHPGHS	ANKRD53	311	Q8N9V6
VLEQHPDGRWKGCIH	CASKIN1	311	Q8WXD9
SLEDWHHEAIPICHG	NPY4R	286	P50391
IKCHVHDPHGQVIWG	FBXO39	256	Q8N4B4
HPHSHPLYGHGVCKW	FOXP1	296	Q9H334
IHPVGWCEKTKHELH	L3MBTL4	136	Q8NA19
VLEQHPDGRWKGHIH	CASKIN2	311	Q8WXE0
KIVGKWHLGHRPQFH	GALNS	136	P34059
IPHLKRGHIEDCGHW	EPHX2	511	P34913
RLPVEGHHGTWLGHK	DAGLA	416	Q9Y4D2
IHPSSCHGWILGEHG	LDHB	181	P07195
AVLGHELGHWKLGHT	ZMPSTE24	331	O75844
AELPPDHEHKTLGHW	SYNJ2	1461	O15056
HHTGDLAHRGKLWPV	NKPD1	581	Q17RQ9
RPWGQHDCHHREDAG	SSC5D	386	A1L4H1
WTHRGDCLVHVPGDH	STARD8	211	Q92502
LHEDVPWCRGEGHKP	ACVR2B	301	Q13705
HHAGVLPWHDGKQVH	CLPTM1L	111	Q96KA5
LIKVHRHHLGLCWPI	C12orf29	261	Q8N999
PSGWHGVHCEKSDRI	TIE1	336	P35590
SLEDWHHEAIPICHG	NPY4R2	286	P0DQD5
RGHGADVKCVDWHPT	WDR33	241	Q9C0J8
AHRPHVVGAKWLLEC	TOPBP1	416	Q92547
HLHILHRPWKCGLCS	ZNF219	181	Q9P2Y4
ERVCHCLGKWLGHPD	PLP1	136	P60201