Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	Rab GDP-dissociation inhibitor activity	GDI1 GDI2	1.04e-05	2	65	2	GO:0005093
GeneOntologyMolecularFunction	mannose-ethanolamine phosphotransferase activity	PIGN PIGG	6.23e-05	4	65	2	GO:0051377
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN4A PKD2 SCN10A	8.11e-05	26	65	3	GO:0005248
GeneOntologyMolecularFunction	guanylate cyclase activity	NPR2 GUCY1A2	4.62e-04	10	65	2	GO:0004383
GeneOntologyMolecularFunction	small GTPase binding	DOCK2 ATP6AP1 XPO6 DEPDC5 GDI1 GDI2	6.13e-04	321	65	6	GO:0031267
GeneOntologyMolecularFunction	sodium channel activity	SCN4A PKD2 SCN10A	6.49e-04	52	65	3	GO:0005272
GeneOntologyMolecularFunction	monoatomic ion channel activity	LRRC8E KCNH8 GJD3 SCN4A PKD2 SCN10A GRIN2A	7.14e-04	459	65	7	GO:0005216
GeneOntologyMolecularFunction	GTPase binding	DOCK2 ATP6AP1 XPO6 DEPDC5 GDI1 GDI2	1.11e-03	360	65	6	GO:0051020
GeneOntologyMolecularFunction	GDP-dissociation inhibitor activity	GDI1 GDI2	1.37e-03	17	65	2	GO:0005092
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase adaptor activity	GAB4 GAB2	1.54e-03	18	65	2	GO:0005068
GeneOntologyMolecularFunction	channel activity	LRRC8E KCNH8 GJD3 SCN4A PKD2 SCN10A GRIN2A	1.56e-03	525	65	7	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	LRRC8E KCNH8 GJD3 SCN4A PKD2 SCN10A GRIN2A	1.57e-03	526	65	7	GO:0022803
GeneOntologyMolecularFunction	GTPase activator activity	DOCK2 ARFGEF1 DEPDC5 GDI1 GDI2	2.14e-03	279	65	5	GO:0005096
GeneOntologyMolecularFunction	phosphotransferase activity, for other substituted phosphate groups	PIGN PIGG	2.31e-03	22	65	2	GO:0016780
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SCN4A PKD2 SCN10A SLC4A5	2.34e-03	171	65	4	GO:0015081
GeneOntologyMolecularFunction	cyclase activity	NPR2 GUCY1A2	2.75e-03	24	65	2	GO:0009975
GeneOntologyMolecularFunction	olfactory receptor activity	OR4P4 OR4D9 OR2G2 OR2Y1 OR4Q3 OR4K14	2.76e-03	431	65	6	GO:0004984
GeneOntologyMolecularFunction	transporter activity	LRRC8E KCNH8 ATAD1 GJD3 SCN4A PKD2 SCN10A GRIN2A RFT1 SLC4A5 ABCA10	2.77e-03	1289	65	11	GO:0005215
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	KCNH8 PKD2 SCN10A GRIN2A	2.93e-03	182	65	4	GO:0005244
GeneOntologyMolecularFunction	phosphorus-oxygen lyase activity	NPR2 GUCY1A2	2.98e-03	25	65	2	GO:0016849
GeneOntologyMolecularFunction	voltage-gated channel activity	KCNH8 PKD2 SCN10A GRIN2A	3.05e-03	184	65	4	GO:0022832
GeneOntologyMolecularFunction	calcium/calmodulin-dependent protein kinase activity	PHKA1 CAMKV	3.47e-03	27	65	2	GO:0004683
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	KCNH8 SCN4A PKD2 SCN10A GRIN2A SLC4A5	4.00e-03	465	65	6	GO:0046873
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	LRRC8E KCNH8 GJD3 SCN4A PKD2 SCN10A GRIN2A SLC4A5	4.08e-03	793	65	8	GO:0015075
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	PKD2 GRIN2A	4.57e-03	31	65	2	GO:0099604
MousePheno	decreased mast cell degranulation	ADORA3 GAB4 GAB2	4.99e-05	20	51	3	MP:0008765
MousePheno	enlarged parietal bone	NPR2 HYDIN	7.79e-05	4	51	2	MP:0004421
Domain	RabGDI	GDI1 GDI2	1.19e-05	2	65	2	IPR000806
Domain	GDI	GDI1 GDI2	7.12e-05	4	65	2	PF00996
Domain	GDP_dissociation_inhibitor	GDI1 GDI2	7.12e-05	4	65	2	IPR018203
Domain	IQ	LRRIQ1 MYO7B SCN4A SCN10A	1.09e-04	71	65	4	PF00612
Domain	IQ_motif_EF-hand-BS	LRRIQ1 MYO7B SCN4A SCN10A	2.73e-04	90	65	4	IPR000048
Domain	IQ	LRRIQ1 MYO7B SCN4A SCN10A	3.09e-04	93	65	4	PS50096
Domain	Na_channel_asu	SCN4A SCN10A	5.27e-04	10	65	2	IPR001696
Domain	Phosphodiest	PIGN PIGG	5.27e-04	10	65	2	PF01663
Domain	Na_trans_assoc	SCN4A SCN10A	5.27e-04	10	65	2	IPR010526
Domain	Phosphodiest/P_Trfase	PIGN PIGG	5.27e-04	10	65	2	IPR002591
Domain	Na_trans_assoc	SCN4A SCN10A	5.27e-04	10	65	2	PF06512
Domain	Channel_four-helix_dom	SCN4A PKD2 SCN10A	1.03e-03	57	65	3	IPR027359
Domain	-	SCN4A PKD2 SCN10A	1.03e-03	57	65	3	1.20.120.350
Domain	A/G_cyclase_CS	NPR2 GUCY1A2	1.57e-03	17	65	2	IPR018297
Domain	AAA+_ATPase	ATAD1 NAV3 ABCF2 ABCA10	1.59e-03	144	65	4	IPR003593
Domain	AAA	ATAD1 NAV3 ABCF2 ABCA10	1.59e-03	144	65	4	SM00382
Domain	Nucleotide_cyclase	NPR2 GUCY1A2	1.76e-03	18	65	2	IPR029787
Domain	-	NPR2 GUCY1A2	1.76e-03	18	65	2	3.30.70.1230
Domain	GUANYLATE_CYCLASE_1	NPR2 GUCY1A2	1.96e-03	19	65	2	PS00452
Domain	Guanylate_cyc	NPR2 GUCY1A2	1.96e-03	19	65	2	PF00211
Domain	GUANYLATE_CYCLASE_2	NPR2 GUCY1A2	1.96e-03	19	65	2	PS50125
Domain	A/G_cyclase	NPR2 GUCY1A2	1.96e-03	19	65	2	IPR001054
Domain	CYCc	NPR2 GUCY1A2	1.96e-03	19	65	2	SM00044
Domain	GPCR_Rhodpsn_7TM	ADORA3 OR4P4 DRD3 OR4D9 OR2G2 OR2Y1 OR4Q3 OR4K14	2.19e-03	670	65	8	IPR017452
Domain	7tm_1	ADORA3 OR4P4 DRD3 OR4D9 OR2G2 OR2Y1 OR4Q3 OR4K14	2.33e-03	677	65	8	PF00001
Domain	Olfact_rcpt	OR4P4 OR4D9 OR2G2 OR2Y1 OR4Q3 OR4K14	2.42e-03	393	65	6	IPR000725
Domain	G_PROTEIN_RECEP_F1_1	ADORA3 OR4P4 DRD3 OR4D9 OR2G2 OR2Y1 OR4Q3 OR4K14	2.51e-03	685	65	8	PS00237
Domain	G_PROTEIN_RECEP_F1_2	ADORA3 OR4P4 DRD3 OR4D9 OR2G2 OR2Y1 OR4Q3 OR4K14	2.65e-03	691	65	8	PS50262
Domain	GPCR_Rhodpsn	ADORA3 OR4P4 DRD3 OR4D9 OR2G2 OR2Y1 OR4Q3 OR4K14	2.67e-03	692	65	8	IPR000276
Domain	IQ	LRRIQ1 MYO7B SCN4A	2.83e-03	81	65	3	SM00015
Domain	Ubiquitin-rel_dom	RGL1 MYO7B USP24 FRMD4B	3.87e-03	184	65	4	IPR029071
Domain	Alkaline_phosphatase_core	PIGN PIGG	5.20e-03	31	65	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	PIGN PIGG	5.20e-03	31	65	2	IPR017849
Domain	-	PIGN PIGG	5.20e-03	31	65	2	3.40.720.10
Domain	ARM-type_fold	DOCK2 XPO6 MROH2B USP24 ARFGEF1	6.49e-03	339	65	5	IPR016024
Domain	ANF_lig-bd_rcpt	NPR2 GRIN2A	7.34e-03	37	65	2	IPR001828
Domain	ANF_receptor	NPR2 GRIN2A	7.34e-03	37	65	2	PF01094
Domain	Ion_trans_dom	KCNH8 SCN4A SCN10A	7.35e-03	114	65	3	IPR005821
Domain	Ion_trans	KCNH8 SCN4A SCN10A	7.35e-03	114	65	3	PF00520
Domain	Peripla_BP_I	NPR2 GRIN2A	8.13e-03	39	65	2	IPR028082
Domain	P-loop_NTPase	LRRIQ1 ATAD1 MYO7B RERGL NAV3 ABCF2 ABCA10 HYDIN	8.94e-03	848	65	8	IPR027417
Domain	ABC_transporter_CS	ABCF2 ABCA10	9.39e-03	42	65	2	IPR017871
Pubmed	Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycin.	GAB4 GAB2	3.44e-06	2	65	2	20535152
Pubmed	Inhibition of GAB2 expression has a protective effect on osteoarthritis:An in vitro and in vivo study.	GAB4 GAB2	3.44e-06	2	65	2	36007472
Pubmed	Gab2 deficiency suppresses high-fat diet-induced obesity by reducing adipose tissue inflammation and increasing brown adipose function in mice.	GAB4 GAB2	3.44e-06	2	65	2	33637697
Pubmed	Abnormal hematopoiesis in Gab2 mutant mice.	GAB4 GAB2	3.44e-06	2	65	2	17374739
Pubmed	Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells.	GAB4 GAB2	3.44e-06	2	65	2	12640133
Pubmed	The pleckstrin homology domain of Gab-2 is required for optimal interleukin-3 signalsome-mediated responses.	GAB4 GAB2	3.44e-06	2	65	2	16275030
Pubmed	Gab2 plays distinct roles in bone homeostasis at different time points.	GAB4 GAB2	3.44e-06	2	65	2	17323176
Pubmed	Gab2 (Grb2-Associated Binder2) Plays a Crucial Role in Inflammatory Signaling and Endothelial Dysfunction.	GAB4 GAB2	3.44e-06	2	65	2	33827252
Pubmed	Docking protein Gab2 positively regulates glycoprotein VI-mediated platelet activation.	GAB4 GAB2	3.44e-06	2	65	2	16198316
Pubmed	Growth factor receptor bound protein 2-associated binder 2, a scaffolding adaptor protein, negatively regulates host immunity against tuberculosis.	GAB4 GAB2	3.44e-06	2	65	2	24805943
Pubmed	Role of Gab2 in mammary tumorigenesis and metastasis.	GAB4 GAB2	3.44e-06	2	65	2	17310989
Pubmed	Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl(+) K562 leukemic cells by Gab2.	GAB4 GAB2	3.44e-06	2	65	2	11830491
Pubmed	Essential role for Gab2 in the allergic response.	GAB4 GAB2	3.44e-06	2	65	2	11449275
Pubmed	The absence of Grb2-associated binder 2 (Gab2) does not disrupt NK cell development and functions.	GAB4 GAB2	3.44e-06	2	65	2	15240750
Pubmed	Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation.	GAB4 GAB2	3.44e-06	2	65	2	9885561
Pubmed	Liver-specific overexpression of Gab2 accelerates hepatocellular carcinoma progression by activating immunosuppression of myeloid-derived suppressor cells.	GAB4 GAB2	3.44e-06	2	65	2	35411035
Pubmed	Requirement of Gab2 for mast cell development and KitL/c-Kit signaling.	GAB4 GAB2	3.44e-06	2	65	2	11861309
Pubmed	G-CSF-dependent neutrophil differentiation requires downregulation of MAPK activities through the Gab2 signaling pathway.	GAB4 GAB2	3.44e-06	2	65	2	32437087
Pubmed	A role for the scaffolding adapter GAB2 in breast cancer.	GAB4 GAB2	3.44e-06	2	65	2	16369543
Pubmed	Deletion of Gab2 in mice protects against hepatic steatosis and steatohepatitis: a novel therapeutic target for fatty liver disease.	GAB4 GAB2	3.44e-06	2	65	2	27282405
Pubmed	Docking protein Gab2 regulates mucin expression and goblet cell hyperplasia through TYK2/STAT6 pathway.	GAB4 GAB2	3.44e-06	2	65	2	22859374
Pubmed	A novel role for Gab2 in bFGF-mediated cell survival during retinoic acid-induced neuronal differentiation.	GAB4 GAB2	3.44e-06	2	65	2	16009726
Pubmed	Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens.	GDI1 GDI2	3.44e-06	2	65	2	7585614
Pubmed	Scaffolding protein Gab2 is involved in postnatal development and lipopolysaccharide-induced activation of microglia in the mouse brain.	GAB4 GAB2	3.44e-06	2	65	2	34146905
Pubmed	Grb2 associated binder 2 couples B-cell receptor to cell survival.	GAB4 GAB2	3.44e-06	2	65	2	18950707
Pubmed	Gab2 is essential for Bcr-Abl-mediated leukemic transformation and hydronephrosis in a chronic myeloid leukemia mouse model.	GAB4 GAB2	3.44e-06	2	65	2	27125306
Pubmed	Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor‑associated macrophages.	GAB4 GAB2	3.44e-06	2	65	2	37937666
Pubmed	Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1.	GAB4 GAB2	3.44e-06	2	65	2	26773044
Pubmed	A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.	GAB4 GAB2	1.03e-05	3	65	2	20651068
Pubmed	RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.	GDI1 GDI2	1.03e-05	3	65	2	26240314
Pubmed	Gab2 promotes colony-stimulating factor 1-regulated macrophage expansion via alternate effectors at different stages of development.	GAB4 GAB2	1.03e-05	3	65	2	21930791
Pubmed	Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.	GAB4 GAB2	1.03e-05	3	65	2	12821647
Pubmed	Comparative FISH mapping of Gab1 and Gab2 genes in human, mouse and rat.	GAB4 GAB2	1.03e-05	3	65	2	11701952
Pubmed	Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation.	GAB4 GAB2	1.03e-05	3	65	2	19581930
Pubmed	Unique properties of PTEN-L contribute to neuroprotection in response to ischemic-like stress.	GAB4 GAB2	1.03e-05	3	65	2	30816308
Pubmed	Non-redundant roles of the Gab1 and Gab2 scaffolding adapters in VEGF-mediated signalling, migration, and survival of endothelial cells.	GAB4 GAB2	1.03e-05	3	65	2	19233262
Pubmed	Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport.	GDI1 GDI2	1.03e-05	3	65	2	7543319
Pubmed	The Gab2-MALT1 axis regulates thromboinflammation and deep vein thrombosis.	GAB4 GAB2	1.03e-05	3	65	2	35895897
Pubmed	Tex261 modulates the excitotoxic cell death induced by N-methyl-D-aspartate (NMDA) receptor activation.	TEX261 GRIN2A	1.03e-05	3	65	2	17803966
Pubmed	Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle.	GDI1 GDI2	1.03e-05	3	65	2	7513052
Pubmed	GRB2-mediated recruitment of GAB2, but not GAB1, to SF-STK supports the expansion of Friend virus-infected erythroid progenitor cells.	GAB4 GAB2	1.03e-05	3	65	2	16314834
Pubmed	Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8+ T-Cell Activation.	GAB4 GAB2	1.03e-05	3	65	2	30936879
Pubmed	Grb2-associated binder-1 is required for neuregulin-1-induced peripheral nerve myelination.	GAB4 GAB2	2.06e-05	4	65	2	24872569
Pubmed	The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo.	GAB4 GAB2	2.06e-05	4	65	2	19171907
Pubmed	Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5.	GAB4 GAB2	2.06e-05	4	65	2	20161778
Pubmed	Cooperative interaction of hepatocyte growth factor and neuregulin regulates Schwann cell migration and proliferation through Grb2-associated binder-2 in peripheral nerve repair.	GAB4 GAB2	2.06e-05	4	65	2	28722233
Pubmed	Gab2, via PI-3K, regulates ARF1 in FcεRI-mediated granule translocation and mast cell degranulation.	GAB4 GAB2	2.06e-05	4	65	2	21653832
Pubmed	Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement.	GAB4 GAB2	2.06e-05	4	65	2	19258595
Pubmed	Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility.	GAB4 GAB2	2.06e-05	4	65	2	23401857
Pubmed	Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo.	GAB4 GAB2	2.06e-05	4	65	2	34903841
Pubmed	Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.	GAB4 GAB2	2.06e-05	4	65	2	27840422
Pubmed	Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.	GAB4 GAB2	2.06e-05	4	65	2	22806893
Pubmed	The limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cells.	GAB4 GAB2	2.06e-05	4	65	2	20335178
Pubmed	GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol.	PIGN PIGG	2.06e-05	4	65	2	15632136
Pubmed	Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis.	GAB4 GAB2	2.06e-05	4	65	2	12058075
Pubmed	TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing.	PIWIL4 TASOR2	2.06e-05	4	65	2	32719317
Pubmed	The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis.	GAB4 GAB2	2.06e-05	4	65	2	15750601
Pubmed	A novel Stat3 binding motif in Gab2 mediates transformation of primary hematopoietic cells by the Stk/Ron receptor tyrosine kinase in response to Friend virus infection.	GAB4 GAB2	2.06e-05	4	65	2	17353274
Pubmed	Insulin potentiates FcepsilonRI-mediated signaling in mouse bone marrow-derived mast cells.	GAB4 GAB2	3.43e-05	5	65	2	20004975
Pubmed	Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling.	GAB4 GAB2	3.43e-05	5	65	2	17571162
Pubmed	GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation.	GDI1 GDI2	3.43e-05	5	65	2	19570034
Pubmed	Genome-wide association study identifies two susceptibility loci for osteosarcoma.	GDI2 TASOR2	3.43e-05	5	65	2	23727862
Pubmed	PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.	GAB4 GAB2	3.43e-05	5	65	2	17053833
Pubmed	Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport.	GDI1 GDI2	3.43e-05	5	65	2	11929610
Pubmed	Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI.	GAB4 GAB2	3.43e-05	5	65	2	16456001
Pubmed	Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice.	GAB4 GAB2	3.43e-05	5	65	2	28687632
Pubmed	The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway.	GAB4 GAB2	3.43e-05	5	65	2	16873377
Pubmed	G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative, not proliferative, responses.	GAB4 GAB2	3.43e-05	5	65	2	14656892
Pubmed	Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors.	GAB4 GAB2	5.13e-05	6	65	2	10068651
Pubmed	Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane.	GAB4 GAB2	5.13e-05	6	65	2	15998803
Pubmed	Interleukin-3 (IL-3)-induced c-fos activation is modulated by Gab2-calcineurin interaction.	GAB4 GAB2	5.13e-05	6	65	2	18586679
Pubmed	Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/c-met signaling.	GAB4 GAB2	5.13e-05	6	65	2	21293003
Pubmed	Construction of a transcription map of a 300 kb region around the human G6PD locus by direct cDNA selection.	ATP6AP1 GDI1	5.13e-05	6	65	2	8281148
Pubmed	The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.	GDI1 GDI2	5.13e-05	6	65	2	11809807
Pubmed	Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination.	GAB4 GAB2	5.13e-05	6	65	2	31944179
Pubmed	The signaling adapter, FRS2, facilitates neuronal branching in primary cortical neurons via both Grb2- and Shp2-dependent mechanisms.	GAB4 GAB2	5.13e-05	6	65	2	25159185
Pubmed	Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinase.	GAB4 GAB2	7.18e-05	7	65	2	11287610
Pubmed	Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase.	GAB4 GAB2	7.18e-05	7	65	2	10995764
Pubmed	Rapid and large amount of autocrine IL-3 production is responsible for mast cell survival by IgE in the absence of antigen.	GAB4 GAB2	7.18e-05	7	65	2	15542585
Pubmed	Transcriptional organization of a 450-kb region of the human X chromosome in Xq28.	ATP6AP1 GDI1	9.56e-05	8	65	2	8248200
Pubmed	Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis.	GAB4 GAB2	9.56e-05	8	65	2	23478294
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN4A SCN10A	1.23e-04	9	65	2	16382098
Pubmed	A Cellular Mechanism to Detect and Alleviate Reductive Stress.	CUL2 DEPDC5	1.23e-04	9	65	2	32941802
Pubmed	Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit.	GAB4 GAB2	1.23e-04	9	65	2	18697750
Pubmed	Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration.	GAB4 GAB2	1.23e-04	9	65	2	11895767
Pubmed	Two-hybrid system screen with the small GTP-binding protein Rab6. Identification of a novel mouse GDP dissociation inhibitor isoform and two other potential partners of Rab6.	GDI2 TASOR2	1.23e-04	9	65	2	7782346
Pubmed	The human ATP-binding cassette (ABC) transporter superfamily.	ABCF2 ABCA10	1.53e-04	10	65	2	11435397
Pubmed	MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met.	GAB4 GAB2	1.53e-04	10	65	2	15314156
Pubmed	GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2.	GAB4 GAB2	2.65e-04	13	65	2	12819203
Pubmed	Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci.	ATP6AP1 GDI1	3.08e-04	14	65	2	8733135
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	LRRC8E ATP6AP1 ARFGEF1 PIGG NAA50 RFT1 GDI2 ARCN1	3.89e-04	952	65	8	38569033
Pubmed	Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis.	PIGN PIGG	4.59e-04	17	65	2	11102867
Pubmed	Genome-wide association with bone mass and geometry in the Framingham Heart Study.	KCNH8 FRMD4B	5.76e-04	19	65	2	17903296
Pubmed	Frs2α and Shp2 signal independently of Gab to mediate FGF signaling in lens development.	GAB4 GAB2	7.06e-04	21	65	2	24284065
Pubmed	Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.	ABCF2 ABCA10	7.76e-04	22	65	2	8894702
Pubmed	High Throughput Chemical Screening Reveals Multiple Regulatory Proteins on FOXA1 in Breast Cancer Cell Lines.	PHKA1 ATAD1 ARCN1 HNRNPH3	8.20e-04	223	65	4	30572598
Pubmed	Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays.	SCN4A GRIN2A	8.48e-04	23	65	2	16637659
Pubmed	The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord.	NPR2 GUCY1A2	8.48e-04	23	65	2	17954614
Pubmed	Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ.	NR1I2 GYS2	8.48e-04	23	65	2	27531557
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	RGL1 NAV3 FRMD4B	9.37e-04	102	65	3	10231032
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN4A SCN10A	2.06e-04	9	44	2	1203
GeneFamily	Olfactory receptors, family 4	OR4P4 OR4D9 OR4Q3 OR4K14	2.69e-04	129	44	4	151
GeneFamily	Glycosyl transferases group 1 domain containing\|Phosphatidylinositol glycan anchor biosynthesis	PIGN PIGG	1.18e-03	21	44	2	680
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	MYO7B FRMD4B	6.58e-03	50	44	2	1293
Coexpression	GSE17301_ACD3_ACD28_VS_ACD3_ACD28_AND_IFNA2_STIM_CD8_TCELL_UP	CHST10 SCN4A ABCF2 NAA50 TERT GAB2	8.42e-06	199	63	6	M8035
Disease	glycogen storage disease (is_implicated_in)	PHKA1 GYS2	1.55e-04	9	62	2	DOID:2747 (is_implicated_in)
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN4A SCN10A	1.93e-04	10	62	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN4A SCN10A	1.93e-04	10	62	2	DOID:0080422 (implicated_via_orthology)
Disease	cancer (implicated_via_orthology)	DEPDC5 RFT1 TERT GDI1 GDI2	2.53e-04	268	62	5	DOID:162 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN4A SCN10A	2.83e-04	12	62	2	DOID:0060170 (implicated_via_orthology)
Disease	epilepsy (implicated_via_orthology)	SCN4A SCN10A DEPDC5 GRIN2A	3.90e-04	163	62	4	DOID:1826 (implicated_via_orthology)
Disease	Colorectal Carcinoma	ADORA3 GUCY1A2 ATAD1 ARFGEF1 GRIN2A CUBN ABCA10	6.62e-04	702	62	7	C0009402
Disease	interleukin-2 receptor subunit alpha measurement	GDI2 TASOR2	8.89e-04	21	62	2	EFO_0010587
Disease	chronic myeloid leukemia (is_marker_for)	TERT GAB2	1.47e-03	27	62	2	DOID:8552 (is_marker_for)
Disease	melanoma	GRIN2A CUBN TERT GAB2	1.85e-03	248	62	4	C0025202

Protein segments in the cluster

Peptide	Gene	Start	Entry
LTERVVSDKTLSFYF	ABCF2	371	Q9UG63
VGVIFSDTFSYRLKF	ABCA10	36	Q8WWZ4
FYGREFKTAKSLFLV	ADORA3	221	P0DMS8
FFKEIFLYILETSTS	ARFGEF1	526	Q9Y6D6
EKTLFLFIAGRYEFS	GYS2	321	P54840
IRFFSFSLIEGYISL	CASTOR2	226	A6NHX0
FVLKITDYGLASFRS	NPR2	656	P20594
LRREFFTTTTKEGYD	CCDC90B	31	Q9GZT6
SYRDVTLFEGKRVSF	C9orf64	191	Q5T6V5
IEESFYIFFAKVLER	RFT1	296	Q96AA3
FLSTYRGFASTKEVL	RGL1	96	Q9NZL6
VTVVLFSRTFYDAKS	DEPDC5	216	O75140
RDQGKFVSLFYTVVT	OR2G2	271	Q8NGZ5
VTRYLDFKVTEGSFV	GDI2	96	P50395
YDIRKTIFTFTPQFI	PHKA1	511	P46020
IDFYRKFGFEIIETK	NAA50	121	Q9GZZ1
SEREGKFVALFYTII	OR2Y1	266	Q8NGV0
IFVYVRPFSRFSVDK	OR4K14	256	Q8NGD5
FSVDKLLSVFYTIFT	OR4K14	266	Q8NGD5
TTFSEDKVFALFYTI	OR4P4	261	Q8NGL7
FSVDKIFSLFYTVIT	OR4Q3	266	Q8NH05
FKEYVFRIDTSTSLG	NAV3	1961	Q8IVL0
IEIFRSSRSEIKGFY	HNRNPH3	86	P31942
LYSKRFAVFLSEVSE	LRRC8E	376	Q6NSJ5
FKGIISFAKVISYFR	NR1I2	251	O75469
TRIGYSFFLEEKLVD	LRRIQ1	896	Q96JM4
YTRVKEFTFLGITQS	OR4D9	6	Q8NGE8
EQITDFGFKFSYRII	CUBN	3021	O60494
FAVRFYIESISFLKD	FRMD4B	136	Q9Y2L6
RFKETLVYQTRVFEF	HYDIN	3811	Q4G0P3
VDVFVTRKEYFIFLE	CAMKV	86	Q8NCB2
EYVFKFIVRSRTLFS	DOCK2	741	Q92608
FDIKTSERTFYLVAE	GAB4	121	Q2WGN9
VEDRLTSFITVFKYI	CUL2	411	Q13617
VSRPTEKTVFVLFYF	GJD3	181	Q8N144
VTRYLDFKVVEGSFV	GDI1	96	P31150
FAYTRIVFTDQVLKF	SPAM1	301	P38567
RFSTETTFLVDKYEI	ARCN1	496	P48444
VIYTTFNIEFRKAFL	DRD3	381	P35462
TTYQLLKREESFTFI	GUCY1A2	661	P33402
VYYVRSTGSIIEFIF	RNF139	461	Q8WU17
FDIKTSERTFYLVAE	GAB2	86	Q9UQC2
KYSRSEVVLTFFERS	PXDC1	116	Q5TGL8
TVRFLTKRFIGEYAS	RERGL	21	Q9H628
EYTFTGIYTFESLIK	SCN4A	161	P35499
LVAVYVSDFFKERTS	PLPP1	241	O14494
FAISVSYFERKLLFS	PIWIL4	246	Q7Z3Z4
VSFYFKEIVLQTRTF	MROH2B	1381	Q7Z745
FRLTIFGAVTYFTIK	ATAD1	21	Q8NBU5
TYFKFFIVRDPFERL	CHST10	181	O43529
TVFFDEFTFVKLTGV	VNN1	336	O95497
TVKALLEYTDRVFTF	SCN10A	1181	Q9Y5Y9
LFDVLRSVVFFYIKS	RNF123	426	Q5XPI4
IFFSTLIYKFGRTEE	TMEM50B	141	P56557
VATDASFIIKYITRF	SLC4A5	621	Q9BY07
SFIIKYITRFTEEGF	SLC4A5	626	Q9BY07
LTYERLFGTTVTFKF	ATP6AP1	311	Q15904
FSTAVLIGLYVFERF	TEX261	51	Q6UWH6
FTLGIEVLVLSFFYR	PIGN	551	O95427
KLIRYVTTFDFFLAA	PKD2	461	Q13563
EYFISSEGRELIKIF	USP24	2211	Q9UPU5
LFYLVETEDKSFFVR	TASOR2	2186	Q5VWN6
SYIEKFTDFLRLFVS	XPO6	366	Q96QU8
DISKGIIEARFVYVF	PIGG	751	Q5H8A4
LLRSFFYVTETTFQK	TERT	556	O14746
FRTTYVSKSGQVIFE	KCNH8	276	Q96L42
IRKSGFPIRYTFEEF	MYO7B	686	Q6PIF6
IFPGYREFISFVKTT	GRIN2A	176	Q12879