Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domainzf-C2H2_6

ZNF787 ZNF8 ZNF627 ZNF526 MECOM ZNF229 ZNF467 ZNF77 ZNF114

4.94e-07314589PF13912
Domain-

ZNF787 ZNF8 ZNF627 ZNF776 ZNF526 ZNF507 MECOM ZNF565 ZNF229 ZNF467 ZNF77 ZNF114

9.30e-0767958123.30.160.60
Domainzf-C2H2

ZNF787 ZNF8 ZNF627 ZNF776 ZNF526 ZNF507 MECOM ZNF565 ZNF229 ZNF467 ZNF77 ZNF114

1.15e-066935812PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF787 ZNF8 ZNF627 ZNF776 ZNF526 ZNF507 MECOM ZNF565 ZNF229 ZNF467 ZNF77 ZNF114

1.17e-066945812IPR013087
DomainZINC_FINGER_C2H2_2

ZNF787 ZNF8 ZNF627 ZNF776 ZNF526 ZNF507 MECOM ZNF565 ZNF229 ZNF467 ZNF77 ZNF114

3.68e-067755812PS50157
DomainZINC_FINGER_C2H2_1

ZNF787 ZNF8 ZNF627 ZNF776 ZNF526 ZNF507 MECOM ZNF565 ZNF229 ZNF467 ZNF77 ZNF114

3.78e-067775812PS00028
DomainZnf_C2H2-like

ZNF787 ZNF8 ZNF627 ZNF776 ZNF526 ZNF507 MECOM ZNF565 ZNF229 ZNF467 ZNF77 ZNF114

4.84e-067965812IPR015880
DomainZnf_C2H2

ZNF787 ZNF8 ZNF627 ZNF776 ZNF526 ZNF507 MECOM ZNF565 ZNF229 ZNF467 ZNF77 ZNF114

5.43e-068055812IPR007087
DomainZnF_C2H2

ZNF787 ZNF8 ZNF627 ZNF776 ZNF526 ZNF507 MECOM ZNF565 ZNF229 ZNF467 ZNF77 ZNF114

5.64e-068085812SM00355
DomainDC_STAMP-like

DCST1 OCSTAMP

5.66e-054582IPR012858
DomainDC_STAMP

DCST1 OCSTAMP

5.66e-054582PF07782
DomainKRAB

ZNF8 ZNF627 ZNF776 ZNF565 ZNF229 ZNF77 ZNF114

1.16e-04358587PS50805
DomainKRAB

ZNF8 ZNF627 ZNF776 ZNF565 ZNF229 ZNF77 ZNF114

1.16e-04358587PF01352
DomainKRAB

ZNF8 ZNF627 ZNF776 ZNF565 ZNF229 ZNF77 ZNF114

1.40e-04369587SM00349
DomainKRAB

ZNF8 ZNF627 ZNF776 ZNF565 ZNF229 ZNF77 ZNF114

1.43e-04370587IPR001909
DomainRCC1

HERC2 HERC1

1.74e-0320582PF00415
DomainRCC1_1

HERC2 HERC1

1.92e-0321582PS00625
DomainRCC1_2

HERC2 HERC1

1.92e-0321582PS00626
DomainRCC1_3

HERC2 HERC1

1.92e-0321582PS50012
DomainReg_chr_condens

HERC2 HERC1

2.10e-0322582IPR000408
Domain-

HERC2 HERC1

2.10e-03225822.130.10.30
DomainRCC1/BLIP-II

HERC2 HERC1

2.30e-0323582IPR009091
DomainCadherin_cytoplasmic-dom

CDH12 CDH15

2.72e-0325582IPR000233
DomainCadherin_C

CDH12 CDH15

2.72e-0325582PF01049
DomaincEGF

LRP1 FBN3

2.94e-0326582IPR026823
DomaincEGF

LRP1 FBN3

2.94e-0326582PF12662
DomainHECT

HERC2 HERC1

3.16e-0327582PF00632
DomainHECTc

HERC2 HERC1

3.16e-0327582SM00119
DomainHECT_dom

HERC2 HERC1

3.16e-0327582IPR000569
DomainHECT

HERC2 HERC1

3.16e-0327582PS50237
DomainCatenin_binding_dom

CDH12 CDH15

3.65e-0329582IPR027397
Domain-

CDH12 CDH15

3.65e-03295824.10.900.10
DomainEGF

LRP1 FBN3 TMEFF2

7.06e-03126583PF00008
DomainWD40_repeat

BOP1 LRBA HERC2 HERC1

1.01e-02272584IPR001680
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

CACNA1A NCOR1 AMFR SPATS2L BOP1 HERC2 GNL1 KRIT1

1.57e-0647560831040226
Pubmed

Anti-ataxic effects of TRH and its analogue, TA-0910, in Rolling mouse Nagoya by metabolic normalization of the ventral tegmental area.

CACNA1A TRH

2.93e-0626028719807
Pubmed

The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.

MECOM HERC2 CDH12

3.26e-061760323502783
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

ZNF8 NCOR1 ZNF507 LRP1 MECOM LRBA PCNT

7.69e-0641860734709266
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

FLG RBM15B ACIN1 MECOM BOP1 PAF1 THRAP3 NGDN

9.25e-0660560828977666
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF8 ZNF627 ZNF776 ZNF229 ZNF77

1.56e-0518160537372979
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

CACNA1A MAGI2 NCOR1 LRP1 PRKCE HERC2 PAF1 THRAP3 PCNT

3.84e-0596360928671696
Pubmed

The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities.

HERC2 HERC1

6.11e-0576029949213
Pubmed

The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis.

ZNF8 ZNF507 PAF1

8.50e-054960332918875
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

NCOR1 SPATS2L PNPLA6 RBM15B ACIN1 BOP1 THRAP3 NGDN

1.00e-0484760835850772
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

SPATS2L CSNK1G1 RBM15B ACIN1 BOP1 HERC2 GNL1 THRAP3 TRMT61A NGDN

1.10e-041371601036244648
Pubmed

Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins.

CDH12 CDH15

1.31e-041060210861224
Pubmed

Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity.

CDH12 CDH15

2.26e-04136029615235
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

SPATS2L ACIN1 BOP1 PAF1 NGDN

2.73e-0433260525693804
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

NCOR1 ZNF776 LRP1 MECOM

2.93e-0418460432908313
Pubmed

Association of CPI-17 with protein kinase C and casein kinase I.

CSNK1G1 PRKCE

3.03e-041560215003508
Pubmed

Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.

ACIN1 PAF1 THRAP3 NGDN

3.18e-0418860429721183
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

MAGI2 AMFR KMT5B ACIN1 BOP1 LRBA HERC2 HERC1 THRAP3

3.36e-04128460917353931
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

NCOR1 MCU ACIN1 BOP1 LRBA PAF1 THRAP3 ILVBL NGDN

4.07e-04131860930463901
Pubmed

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.

SCN3A LRP1

4.40e-041860210827173
Pubmed

Phosphoproteome analysis of the human mitotic spindle.

BOP1 THRAP3 PCNT NGDN

4.83e-0421060416565220
Pubmed

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.

CDH12 CDH15

5.45e-04206027806582
Pubmed

CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma.

ACIN1 HERC2 THRAP3

5.85e-049460337468549
Pubmed

FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.

FLG SPATS2L PNPLA6 MECOM PAF1 THRAP3

5.89e-0460160633658012
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

AMFR HERC2 HERC1

6.04e-049560329643511
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ZNF8 ZNF526 PNPLA6 KMT5B LRP1 MECOM ILVBL CDH15

6.39e-04111660831753913
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

USP31 MAGI2 ACIN1 R3HDM2 PCNT

6.90e-0440760512693553
Pubmed

Human transcription factor protein interaction networks.

FLG NCOR1 RC3H1 ZNF507 MECOM R3HDM2 HERC2 HERC1 ILVBL

7.27e-04142960935140242
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

USP31 LRP1 HERC2 HERC1 ZNF114

7.94e-0442060528065597
Pubmed

Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.

NCOR1 ACIN1 PAF1 THRAP3

8.47e-0424460429884807
Pubmed

Defining the membrane proteome of NK cells.

NCOR1 AMFR PIGT PNPLA6 LRBA HERC2 ILVBL PCNT

8.59e-04116860819946888
Pubmed

SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.

FLG SPATS2L HERC1 THRAP3

8.60e-0424560435652658
Pubmed

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.

HERC2 HERC1

9.26e-042660226949039
Pubmed

HIV/AIDS. Persistence by proliferation?

KCTD13 RBM15B

9.26e-042660225013050
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

RBM15B ACIN1 THRAP3 PCNT

9.41e-0425160431076518
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

PNPLA6 TTLL3 LRP1 PRKCE LRBA THRAP3 CDH15 TMEFF2 PCNT

9.73e-04148960928611215
Pubmed

Interspecific backcrosses provide an important new tool for centromere mapping of mouse chromosomes.

ID2 MECOM

9.99e-04276028188294
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

ZNF787 PIGT SPATS2L PNPLA6 RBM15B BOP1 HERC2 ILVBL NGDN

1.01e-03149760931527615
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

ID2 ACIN1 MECOM HERC2 THRAP3 ZNF77 NGDN

1.02e-0392260727609421
Pubmed

Charting the landscape of tandem BRCT domain-mediated protein interactions.

RPGRIP1 AMFR PAF1 THRAP3 ILVBL PCNT

1.04e-0367060622990118
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

AMFR PIGT MCU RBM15B LRP1 ZNF467 THRAP3 ILVBL

1.04e-03120360829180619
Pubmed

The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice.

NCOR1 CDH15

1.15e-032960228364022
Pubmed

BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion.

ID2 MECOM

1.15e-032960217339028
Pubmed

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

LRP1 MECOM

1.23e-033060221946350
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

ZNF787 NCOR1 MECOM PAF1

1.44e-0328260423667531
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

USP31 SPATS2L PNPLA6 LRBA HERC2 HERC1

1.48e-0371960635337019
Pubmed

The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.

CACNA1A RBM15B

1.49e-033360219336002
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

SPATS2L RC3H1 BOP1 PAF1 THRAP3 NGDN

1.54e-0372460636232890
Pubmed

The functional interactome landscape of the human histone deacetylase family.

NCOR1 ACIN1 THRAP3 TRMT61A

1.58e-0328960423752268
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

NCOR1 RBM15B ACIN1 MECOM PAF1 THRAP3 ILVBL NGDN

1.65e-03129460830804502
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZNF787 ZNF8 ZNF776 ZNF526 ZNF507 ZNF565 ZNF229 PAF1 ADM5 ZNF114

3.11e-0611926010chr19q13
Cytoband19q13.43

ZNF787 ZNF8 ZNF776

2.08e-048760319q13.43
Cytoband19p13

CACNA1A FBN3

5.77e-042760219p13
CytobandEnsembl 112 genes in cytogenetic band chr19p13

CACNA1A ZNF627 PNPLA6 FBN3 ILVBL ZNF77

6.06e-04797606chr19p13
Cytoband12q13.3

LRP1 R3HDM2

2.06e-035160212q13.3
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF787 ZNF8 ZNF627 ZNF776 ZNF526 ZNF507 MECOM ZNF565 ZNF229 ZNF467 ZNF77 ZNF114

5.19e-08718421228
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT5B MECOM

2.82e-0334422487
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CACNA1A SPATS2L GLT1D1 ZNF77 PCNT

4.53e-06184595a8c6028d745aaa6ee7842259238694cb50ce0526
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CACNA1A SPATS2L GLT1D1 ZNF77 PCNT

4.53e-06184595081d045f3bc98a36f342de7d50f39c9a888dd7eb
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CACNA1A SPATS2L GLT1D1 ZNF77 PCNT

4.53e-0618459584c20730cd92b9aaa50077d7b625e37e7f9e91d2
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CACNA1A SPATS2L GLT1D1 ZNF77 PCNT

4.53e-06184595d31d4116d1d196633784863781fa45673607a421
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

MAGI2 MCU MECOM PRKCE LRBA

6.48e-061985951996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellControl-Control-Myeloid-immature_Neutrophil|Control / Disease, condition lineage and cell class

CACNA1A SPATS2L GLT1D1 ZNF77 PCNT

6.80e-06200595118321ac443feb42aee171baccfc4610f00a8822
Diseasecerebellar ataxia (implicated_via_orthology)

CACNA1A PNPLA6

8.80e-058532DOID:0050753 (implicated_via_orthology)
Diseasealpha-tocopherol measurement

SCN3A PRKCE

5.89e-0420532EFO_0007898
Diseasesunburn

FLG PRKCE HERC2

6.95e-0496533EFO_0003958
Diseaseanxiety disorder (implicated_via_orthology)

NCOR1 SCN3A

7.15e-0422532DOID:2030 (implicated_via_orthology)
Diseasecolorectal cancer

MAGI2 LRP1 LRBA HERC2 CDH15 PCNT

7.28e-04604536MONDO_0005575
DiseaseFEV change measurement, response to zileuton

GLT1D1 PRKCE

9.25e-0425532EFO_0005921, EFO_0007676
Diseasemultiple myeloma

MECOM HERC2 CDH12

1.09e-03112533EFO_0001378
DiseaseEpileptic encephalopathy

CACNA1A MAGI2

1.33e-0330532C0543888
DiseaseAcute Myeloid Leukemia, M1

TRH ID2 MECOM

1.49e-03125533C0026998
DiseaseAcute Myeloid Leukemia (AML-M2)

TRH ID2 MECOM

1.49e-03125533C1879321

Protein segments in the cluster

PeptideGeneStartEntry
QRDVAQARTHANPRG

ACIN1

611

Q9UKV3
RRHITHDERPHGQQI

KCTD13

311

Q8WZ19
RRSHGQVQRVAFHPA

BOP1

576

Q14137
ERVPPEENQRHHQRR

CACNA1A

2141

O00555
PHVVNQGTRAIVHRN

ERVPABLB-1

311

P60509
DTAARRGQHQVPQHR

ADM5

21

C9JUS6
QEQLRDGSRHPRSHQ

FLG

2596

P20930
EQLRDGSRHPRSHQE

FLG

2921

P20930
GSVQEQSRHGSRHPR

FLG

3241

P20930
AGPHQQSHQESARDR

FLG

3361

P20930
RPRRSAHRDHQVNLA

FBN3

2686

Q75N90
RQETQRRTSNHGHAR

R3HDM2

51

Q9Y2K5
HQNIPSQGHFSERER

RC3H1

931

Q5TC82
NFRHPQDAREARQHA

RBM15B

186

Q8NDT2
PSNLQRHIRSQHVGA

MECOM

331

Q03112
HQHPQRTVSARAARD

PNPLA6

276

Q8IY17
GLGVSRHRQQQHHRT

MCU

36

Q8NE86
HHAARNGQVNLTVRR

MAGI2

846

Q86UL8
RNHNNIGTRRQDPVA

MGAM2

1536

Q2M2H8
HGSDDHVRRPRQVQG

HERC2

4231

O95714
RQGAVRRRVHQVNGH

PRKCE

156

Q02156
HQRRQPRVRSHACEN

LRP1

466

Q07954
RESHTHRDRPSQQQP

CSNK1G1

351

Q9HCP0
RHAAREHRQNPVRGA

KMT5B

511

Q4FZB7
HGNSDRQRRPRQIEA

HERC1

4116

Q15751
RHVLEISRQHEQPGQ

LRBA

1271

P50851
NHPETDRHITDQQGR

KRIT1

376

O00522
VTHHIRRLNQQPSQG

GNL1

56

P36915
QARRATAHTRVPGAH

PCNT

1951

O95613
QTQAQREDGHRPNSH

PAF1

6

Q8N7H5
GRNHPLHIRENRSAA

ILVBL

326

A1L0T0
PHTGNAVTAQRVRAH

GLT1D1

11

Q96MS3
KSRPHRQGAQGHRAQ

DCDC2B

231

A2VCK2
HQNGTRGQRRKQPHT

DCST1

6

Q5T197
RENVIHLPGQRSHFQ

CDH12

36

P55289
QVNVSHARLRPRHQV

CDH15

536

P55291
PRVQVGHRQLHTAGA

RPGRIP1

141

Q96KN7
NSRHEHRRQPHNGFR

SPATS2L

466

Q9NUQ6
QVPRGTLAEHRQHCQ

RNF151

121

Q2KHN1
PRSNRIHRQKQNTGH

TMEFF2

346

Q9UIK5
VSLHHQRPGQNQASR

ID2

86

Q02363
QAQSVHHQRPGSRVS

NCOR1

2106

O75376
HARLQRRHDRHQGQQ

OCSTAMP

446

Q9BR26
RRHDRHQGQQLPLGD

OCSTAMP

451

Q9BR26
LFVPHRHGERRNSNV

SCN3A

611

Q9NY46
VAAAEGRPRLNQHNH

AMFR

406

Q9UKV5
NTGDQHQIPQRHLRS

ZNF77

91

Q15935
PAHNRERNHPRVYQN

THRAP3

56

Q9Y2W1
AQLTRHQRVHTGDRP

ZNF565

416

Q8N9K5
RDARHPHVTRQSQED

NGDN

221

Q8NEJ9
HSQAVHIRPVCRNAR

PIGT

216

Q969N2
QRGAQTQTRHGVLRH

TRMT61A

31

Q96FX7
LNRHIRDHTGREPNE

ZNF627

116

Q7L945
SPHVLRHQGQVLRRQ

TTLL3

581

Q9Y4R7
RGRGVRQNTHIRNHP

ZNF229

326

Q9UJW7
RQNTHIRNHPRAPVG

ZNF229

331

Q9UJW7
VGVRNHRRIHNSDKP

ZNF507

771

Q8TCN5
SVDVTQHKRQHPGRR

TRH

126

P20396
QITHTREEQPHGRSR

ZNF8

486

P17098
HQPSAGARRQHRRTA

ZNF526

281

Q8TF50
ESVRLQRERHHQPQT

USP31

581

Q70CQ4
VRHQRVHQTAGPARP

ZNF467

316

Q7Z7K2
RDEIDTGANRHQRNP

ZNF114

211

Q8NC26
CNLIQHQRVHTGERP

ZNF776

361

Q68DI1
LTRHQRTHTGERPNA

ZNF787

81

Q6DD87