Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

1.70e-1337618GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

2.14e-1338618GO:0070001
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-6 ERVK-8 ERVK-7 ERVK-10

2.56e-0811614GO:0004523
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-6 ERVK-8 ERVK-7 ERVK-10

7.71e-0814614GO:0003964
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-6 ERVK-8 ERVK-7 ERVK-10

4.54e-0721614GO:0035613
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-6 ERVK-8 ERVK-7 ERVK-10

4.83e-0637614GO:0016891
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-6 ERVK-8 ERVK-7 ERVK-10

5.38e-0638614GO:0034061
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-6 ERVK-8 ERVK-7 ERVK-10

1.17e-0546614GO:0016893
GeneOntologyMolecularFunctionendopeptidase activity

ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

4.70e-05430618GO:0004175
GeneOntologyMolecularFunctionWW domain binding

LITAF SHISA5 DAZAP2

5.95e-0525613GO:0050699
GeneOntologyMolecularFunctionRNA nuclease activity

ERVK-6 XRN2 ERVK-8 ERVK-7 ERVK-10

5.96e-05136615GO:0004540
GeneOntologyMolecularFunctionstructural molecule activity

ERVK-6 ERVK-8 ERVK-5 ERVK-19 ERVK-7 ERVK-21 SEC31A ERVK-9 ERVK-10 CRYBG3 ERVK-24

7.09e-058916111GO:0005198
GeneOntologyMolecularFunctionzinc ion binding

ERVK-6 LITAF POLR2A ERVK-8 ERVK-5 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

7.09e-058916111GO:0008270
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-6 ERVK-8 ERVK-7 ERVK-10

9.98e-0579614GO:0004521
GeneOntologyMolecularFunctionnucleotidyltransferase activity

ERVK-6 POLR2A ERVK-8 ERVK-7 ERVK-10

1.01e-04152615GO:0016779
GeneOntologyMolecularFunctionpeptidase activity

ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 PRPF8

1.55e-04654619GO:0008233
GeneOntologyMolecularFunctioncalcium-dependent protein binding

PDCD6IP ANXA7 TSG101 SEC31A

2.30e-0498614GO:0048306
GeneOntologyMolecularFunctionchromatin binding

EOMES WBP2 NCOA3 ARID1B NEUROD1 SUPT5H POLR2A SMARCD2 FOXA2

3.84e-04739619GO:0003682
GeneOntologyMolecularFunctionnuclease activity

ERVK-6 XRN2 ERVK-8 ERVK-7 ERVK-10

6.97e-04231615GO:0004518
GeneOntologyMolecularFunctionubiquitin-like protein ligase binding

CASC3 POLR2A HGS BAG4 DAZAP2 TSG101

7.71e-04358616GO:0044389
GeneOntologyMolecularFunctionendonuclease activity

ERVK-6 ERVK-8 ERVK-7 ERVK-10

7.95e-04136614GO:0004519
GeneOntologyMolecularFunctiontransition metal ion binding

ERVK-6 LITAF POLR2A ERVK-8 ERVK-5 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

8.51e-0411896111GO:0046914
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

EOMES WBP2 SOX7 MEF2B NEUROD1 DMRT3 KLF1 NFATC4 LITAF FUBP1 FOXA2

1.23e-0312446111GO:0000978
GeneOntologyMolecularFunctionprotein domain specific binding

PLSCR4 NCOA3 PDCD6IP KLF1 LITAF SHISA5 HGS DAZAP2 FOXA2

1.28e-03875619GO:0019904
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

EOMES WBP2 SOX7 NCOA3 MEF2B NEUROD1 DMRT3 KLF1 NFATC4 LITAF FUBP1 FOXA2

1.35e-0314596112GO:0000977
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

EOMES WBP2 SOX7 MEF2B NEUROD1 DMRT3 KLF1 NFATC4 LITAF FUBP1 FOXA2

1.46e-0312716111GO:0000987
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

SOX7 NCOA3 MEF2B NEUROD1 KLF1 LITAF FOXA2

1.55e-03560617GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

SOX7 NCOA3 MEF2B NEUROD1 KLF1 LITAF FOXA2

1.64e-03566617GO:0001216
GeneOntologyMolecularFunctioncatalytic activity, acting on RNA

ERVK-6 XRN2 POLR2A ERVK-8 ERVK-7 ERVK-10

1.69e-03417616GO:0140098
GeneOntologyMolecularFunctionperoxisome proliferator activated receptor binding

NCOA3 NFATC4

1.86e-0321612GO:0042975
GeneOntologyMolecularFunctiontranscription factor binding

EOMES WBP2 NCOA3 NEUROD1 KLF1 NFATC4 DAZAP2 FOXA2

1.98e-03753618GO:0008134
GeneOntologyMolecularFunctiontranscription coactivator activity

WBP2 NCOA3 ARID1B SMARCD2 TSG101

2.31e-03303615GO:0003713
GeneOntologyMolecularFunctionpoly(A) binding

PABPC1L PABPC1

3.53e-0329612GO:0008143
GeneOntologyMolecularFunctionubiquitin protein ligase binding

CASC3 POLR2A BAG4 DAZAP2 TSG101

3.65e-03337615GO:0031625
GeneOntologyMolecularFunctionubiquitin binding

KLF1 HGS TSG101

4.30e-03107613GO:0043130
GeneOntologyMolecularFunctionpoly(U) RNA binding

PABPC1L PABPC1

4.84e-0334612GO:0008266
GeneOntologyMolecularFunctionpoly-purine tract binding

PABPC1L PABPC1

5.71e-0337612GO:0070717
GeneOntologyMolecularFunctionpoly-pyrimidine tract binding

PABPC1L PABPC1

6.33e-0339612GO:0008187
GeneOntologyMolecularFunctionubiquitin-like protein binding

KLF1 HGS TSG101

7.06e-03128613GO:0032182
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

ERVK-6 ERVK-8 ERVK-7 ERVK-10

8.42e-03262614GO:0140097
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

EOMES WBP2 NCOA3 NEUROD1 KLF1 DAZAP2

8.54e-03582616GO:0140297
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

EOMES SOX7 NCOA3 MEF2B NEUROD1 DMRT3 KLF1 NFATC4 LITAF FOXA2

9.98e-0314126110GO:0000981
GeneOntologyMolecularFunctionnuclear estrogen receptor binding

WBP2 NCOA3

1.14e-0253612GO:0030331
GeneOntologyBiologicalProcessviral process

ERVK-6 VPS37A PDCD6IP ERVK-8 ERVK-5 ERVK-19 TSG101 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24 PABPC1

7.86e-104646113GO:0016032
GeneOntologyBiologicalProcessDNA integration

ERVK-6 ERVK-8 ERVK-7 ERVK-10

4.85e-0813614GO:0015074
GeneOntologyBiologicalProcessmultivesicular body assembly

VPS37A PDCD6IP HGS TSG101

2.66e-0633614GO:0036258
GeneOntologyBiologicalProcessmultivesicular body organization

VPS37A PDCD6IP HGS TSG101

3.00e-0634614GO:0036257
GeneOntologyBiologicalProcesscell-cell fusion

ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9

5.24e-0685615GO:0140253
GeneOntologyBiologicalProcesssyncytium formation by plasma membrane fusion

ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9

5.24e-0685615GO:0000768
GeneOntologyBiologicalProcesssyncytium formation

ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9

6.57e-0689615GO:0006949
GeneOntologyBiologicalProcessprotein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

VPS37A HGS TSG101

1.09e-0515613GO:0043328
GeneOntologyBiologicalProcessDNA synthesis involved in DNA repair

ERVK-6 ERVK-8 ERVK-7 ERVK-10

1.22e-0548614GO:0000731
GeneOntologyBiologicalProcesspositive regulation of exosomal secretion

PDCD6IP HGS TSG101

1.34e-0516613GO:1903543
GeneOntologyBiologicalProcessmultivesicular body sorting pathway

VPS37A PDCD6IP HGS TSG101

1.56e-0551614GO:0071985
GeneOntologyBiologicalProcessneuroblast division in subventricular zone

NUMBL NUMB

2.58e-053612GO:0021849
GeneOntologyBiologicalProcessregulation of exosomal secretion

PDCD6IP HGS TSG101

2.71e-0520613GO:1903541
GeneOntologyBiologicalProcessviral budding via host ESCRT complex

VPS37A PDCD6IP TSG101

4.18e-0523613GO:0039702
GeneOntologyBiologicalProcessexosomal secretion

PDCD6IP HGS TSG101

4.77e-0524613GO:1990182
GeneOntologyBiologicalProcessextracellular exosome biogenesis

PDCD6IP HGS TSG101

5.40e-0525613GO:0097734
GeneOntologyBiologicalProcessviral budding

VPS37A PDCD6IP TSG101

6.10e-0526613GO:0046755
GeneOntologyBiologicalProcessextracellular vesicle biogenesis

PDCD6IP HGS TSG101

6.84e-0527613GO:0140112
GeneOntologyBiologicalProcesslate endosome to vacuole transport via multivesicular body sorting pathway

VPS37A HGS TSG101

6.84e-0527613GO:0032511
GeneOntologyBiologicalProcessDNA damage response

ERVK-6 SETD2 XRN2 ARID1B FAM168A NFATC4 SHISA5 ERVK-8 SMARCD2 ERVK-7 ERVK-10

1.02e-049596111GO:0006974
GeneOntologyBiologicalProcessRNA-templated DNA biosynthetic process

ERVK-6 ERVK-8 ERVK-7 ERVK-10

1.07e-0483614GO:0006278
GeneOntologyBiologicalProcessDNA repair

ERVK-6 SETD2 XRN2 ARID1B FAM168A ERVK-8 SMARCD2 ERVK-7 ERVK-10

1.14e-04648619GO:0006281
GeneOntologyBiologicalProcessregulation of extracellular exosome assembly

PDCD6IP TSG101

1.28e-046612GO:1903551
GeneOntologyBiologicalProcessendoderm development

EOMES SOX7 SETD2 FOXA2

1.34e-0488614GO:0007492
GeneOntologyBiologicalProcessvirion assembly

VPS37A PDCD6IP TSG101

1.51e-0435613GO:0019068
GeneOntologyBiologicalProcessubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

VPS37A HGS TSG101

1.78e-0437613GO:0043162
GeneOntologyBiologicalProcessextracellular exosome assembly

PDCD6IP TSG101

1.79e-047612GO:0071971
GeneOntologyBiologicalProcesscell division

NCOA3 SETD2 PDCD6IP NUMBL ANAPC1 FUBP1 CNTRL NUMB TSG101

1.96e-04697619GO:0051301
GeneOntologyBiologicalProcesslate endosome to vacuole transport

VPS37A HGS TSG101

2.08e-0439613GO:0045324
GeneOntologyBiologicalProcesslung cell differentiation

FNDC3B NUMB FOXA2

2.60e-0442613GO:0060479
GeneOntologyBiologicalProcesslung epithelial cell differentiation

FNDC3B NUMB FOXA2

2.60e-0442613GO:0060487
GeneOntologyBiologicalProcesschromatin organization

EOMES WBP2 NCOA3 SETD2 ARID1B KLF1 SUPT5H SMARCD2 PABPC1L FOXA2

2.74e-048966110GO:0006325
GeneOntologyBiologicalProcessendosome organization

VPS37A PDCD6IP HGS TSG101

2.75e-04106614GO:0007032
GeneOntologyBiologicalProcessendosome transport via multivesicular body sorting pathway

VPS37A HGS TSG101

2.79e-0443613GO:0032509
GeneOntologyBiologicalProcesschromatin remodeling

EOMES WBP2 NCOA3 SETD2 ARID1B KLF1 SUPT5H SMARCD2 PABPC1L

3.09e-04741619GO:0006338
GeneOntologyBiologicalProcessmembrane fission

VPS37A HGS TSG101

3.87e-0448613GO:0090148
GeneOntologyBiologicalProcessstem cell division

NCOA3 FUBP1 CNTRL

4.12e-0449613GO:0017145
GeneOntologyBiologicalProcessendoderm formation

EOMES SOX7 SETD2

4.12e-0449613GO:0001706
GeneOntologyBiologicalProcessmesendoderm development

EOMES FOXA2

4.65e-0411612GO:0048382
GeneOntologyBiologicalProcessformation of primary germ layer

EOMES SOX7 SETD2 FOXA2

4.98e-04124614GO:0001704
GeneOntologyBiologicalProcesspositive regulation of intracellular estrogen receptor signaling pathway

WBP2 NCOA3

5.57e-0412612GO:0033148
GeneOntologyBiologicalProcessprocess utilizing autophagic mechanism

SETD2 VPS37A PDCD6IP SUPT5H ANXA7 HGS SEC16A TSG101

6.29e-04650618GO:0061919
GeneOntologyBiologicalProcessautophagy

SETD2 VPS37A PDCD6IP SUPT5H ANXA7 HGS SEC16A TSG101

6.29e-04650618GO:0006914
GeneOntologyBiologicalProcessprotein-DNA complex organization

EOMES WBP2 NCOA3 SETD2 ARID1B KLF1 SUPT5H SMARCD2 PABPC1L FOXA2

6.45e-049996110GO:0071824
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

EOMES WBP2 SOX7 NCOA3 MEF2B NEUROD1 KLF1 NFATC4 LITAF SUPT5H SSBP2 FOXA2

6.65e-0413906112GO:0045944
GeneOntologyBiologicalProcessDNA recombination

ERVK-6 SETD2 XRN2 ERVK-8 ERVK-7 ERVK-10

7.52e-04368616GO:0006310
GeneOntologyBiologicalProcessregulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

CASC3 PABPC1

7.65e-0414612GO:2000622
GeneOntologyBiologicalProcesslateral ventricle development

NUMBL NUMB

7.65e-0414612GO:0021670
GeneOntologyBiologicalProcessendomembrane system organization

PLSCR4 VPS37A PDCD6IP SYNGR1 HGS SEC16A TSG101 SEC31A

7.81e-04672618GO:0010256
GeneOntologyBiologicalProcesslung epithelium development

FNDC3B NUMB FOXA2

7.84e-0461613GO:0060428
GeneOntologyBiologicalProcessmRNA transport

ERVK-6 CASC3 SETD2 ERVK-21

8.96e-04145614GO:0051028
GeneOntologyBiologicalProcesspositive regulation of gene expression

ERVK-6 WBP2 NCOA3 SETD2 ARID1B KLF1 NFATC4 FUBP1 POLR2A HGS PABPC1L PABPC1

9.42e-0414466112GO:0010628
GeneOntologyBiologicalProcesstranscription initiation-coupled chromatin remodeling

WBP2 ARID1B PABPC1L

9.44e-0465613GO:0045815
GeneOntologyBiologicalProcessestablishment of protein localization to vacuole

VPS37A HGS TSG101

9.86e-0466613GO:0072666
GeneOntologyBiologicalProcessneuroblast division

NUMBL NUMB

1.01e-0316612GO:0055057
GeneOntologyBiologicalProcesspositive regulation of gene expression, epigenetic

WBP2 ARID1B PABPC1L

1.08e-0368613GO:0141137
GeneOntologyBiologicalProcesspositive regulation of intracellular steroid hormone receptor signaling pathway

WBP2 NCOA3

1.28e-0318612GO:0033145
GeneOntologyBiologicalProcessmRNA export from nucleus

ERVK-6 CASC3 SETD2

1.37e-0374613GO:0006406
GeneOntologyBiologicalProcessmembrane organization

PLSCR4 VPS37A PDCD6IP ANXA7 SYNGR1 HGS SEC16A TSG101 SEC31A

1.38e-03914619GO:0061024
GeneOntologyBiologicalProcessvesicle organization

VPS37A PDCD6IP HGS SEC16A TSG101 SEC31A

1.40e-03415616GO:0016050
GeneOntologyBiologicalProcesspositive regulation of transcription regulatory region DNA binding

NEUROD1 DAZAP2

1.58e-0320612GO:2000679
GeneOntologyBiologicalProcessRNA transport

ERVK-6 CASC3 SETD2 ERVK-21

1.79e-03175614GO:0050658
GeneOntologyBiologicalProcessnucleic acid transport

ERVK-6 CASC3 SETD2 ERVK-21

1.79e-03175614GO:0050657
GeneOntologyBiologicalProcessestablishment of RNA localization

ERVK-6 CASC3 SETD2 ERVK-21

1.91e-03178614GO:0051236
GeneOntologyBiologicalProcessDNA-templated DNA replication

ERVK-6 ERVK-8 ERVK-7 ERVK-10

1.91e-03178614GO:0006261
GeneOntologyCellularComponentendoplasmic reticulum exit site

MIA2 PDCD6IP SEC16A SEC31A

8.19e-0642644GO:0070971
GeneOntologyCellularComponentESCRT complex

VPS37A HGS TSG101

1.27e-0432643GO:0036452
GeneOntologyCellularComponentFlemming body

PDCD6IP CNTRL TSG101

1.82e-0436643GO:0090543
GeneOntologyCellularComponentcytoplasmic stress granule

CASC3 DAZAP2 PABPC1L PABPC1

2.15e-0496644GO:0010494
GeneOntologyCellularComponentlate endosome membrane

VOPP1 VPS37A LITAF HGS TSG101

2.21e-04179645GO:0031902
GeneOntologyCellularComponentbBAF complex

ARID1B SMARCD2

4.09e-0410642GO:0140092
GeneOntologyCellularComponentchromatin

EOMES WBP2 SOX7 NCOA3 MEF2B ARID1B NEUROD1 DMRT3 KLF1 NFATC4 POLR2A SMARCD2 FOXA2

4.66e-0414806413GO:0000785
GeneOntologyCellularComponentESCRT I complex

VPS37A TSG101

5.97e-0412642GO:0000813
GeneOntologyCellularComponentlate endosome

VOPP1 VPS37A LITAF HGS TSG101 ECPAS

6.78e-04348646GO:0005770
GeneOntologyCellularComponentU2-type catalytic step 1 spliceosome

CASC3 PRPF8

8.20e-0414642GO:0071006
GeneOntologyCellularComponentcatalytic step 1 spliceosome

CASC3 PRPF8

8.20e-0414642GO:0071012
GeneOntologyCellularComponentbrahma complex

ARID1B SMARCD2

8.20e-0414642GO:0035060
GeneOntologyCellularComponentcytoplasmic vesicle membrane

VOPP1 VPS37A LITAF ANXA7 SYNGR1 HGS SEC16A NUMB TSG101 SEC31A TMBIM1

1.90e-0313076411GO:0030659
GeneOntologyCellularComponentvesicle membrane

VOPP1 VPS37A LITAF ANXA7 SYNGR1 HGS SEC16A NUMB TSG101 SEC31A TMBIM1

2.12e-0313256411GO:0012506
GeneOntologyCellularComponentendosome membrane

VOPP1 VPS37A LITAF HGS NUMB TSG101 TMBIM1

2.38e-03602647GO:0010008
GeneOntologyCellularComponentmultivesicular body

HGS TSG101 ECPAS

2.50e-0388643GO:0005771
GeneOntologyCellularComponentendosome

VOPP1 VPS37A PDCD6IP LITAF HGS NUMB TSG101 SEC31A ECPAS TMBIM1

2.73e-0311676410GO:0005768
GeneOntologyCellularComponentSWI/SNF complex

ARID1B SMARCD2

3.80e-0330642GO:0016514
GeneOntologyCellularComponentCOPII-coated ER to Golgi transport vesicle

SEC16A SEC31A ECPAS

4.68e-03110643GO:0030134
DomainNumb_domain

NUMBL NUMB

8.51e-062552IPR010449
DomainNumb/numb-like

NUMBL NUMB

8.51e-062552IPR016698
DomainNumbF

NUMBL NUMB

8.51e-062552PF06311
DomainSec16_C

SEC16A SEC31A

2.55e-053552PF12931
DomainACE1_Sec16_Sec31

SEC16A SEC31A

2.55e-053552IPR024298
DomainPID

NUMBL NUMB SHC3

7.51e-0528553PF00640
DomainPolyA

PABPC1L PABPC1

8.47e-055552SM00517
Domain-

PABPC1L PABPC1

8.47e-0555521.10.1900.10
DomainPABP

PABPC1L PABPC1

8.47e-055552PF00658
DomainPABC

PABPC1L PABPC1

8.47e-055552PS51309
DomainPABP_1234

PABPC1L PABPC1

8.47e-055552IPR006515
DomainPABP_HYD

PABPC1L PABPC1

8.47e-055552IPR002004
DomainPID

NUMBL NUMB SHC3

1.13e-0432553PS01179
DomainZF_CCHC

ERVK-6 XRN2 ERVK-5

1.48e-0435553PS50158
DomainPTB

NUMBL NUMB SHC3

2.21e-0440553SM00462
DomainPTB/PI_dom

NUMBL NUMB SHC3

2.38e-0441553IPR006020
DomainZnF_C2HC

ERVK-6 XRN2 ERVK-5

5.69e-0455553SM00343
DomainZnf_CCHC

ERVK-6 XRN2 ERVK-5

5.69e-0455553IPR001878
DomainRRM_dom_euk

PABPC1L PABPC1

2.07e-0323552IPR003954
DomainRRM_1

PABPC1L PABPC1

2.07e-0323552SM00361
Domainzf-CCHC

ERVK-6 ERVK-5

2.07e-0323552PF00098
PathwayREACTOME_HIV_LIFE_CYCLE

VPS37A PDCD6IP SUPT5H POLR2A TSG101

5.32e-05149395M4076
PathwayREACTOME_BUDDING_AND_MATURATION_OF_HIV_VIRION

VPS37A PDCD6IP TSG101

6.11e-0528393M26982
PathwayREACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT

VPS37A HGS TSG101

8.34e-0531393M1009
PathwayREACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT

VPS37A HGS TSG101

8.34e-0531393MM15637
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

EOMES CASC3 NCOA3 MEF2B ARID1B NEUROD1 POLR2A NUMB SMARCD2 FOXA2 PABPC1 SHC3

3.31e-0414323912M509
PathwayWP_MRNA_PROCESSING

XRN2 SUPT5H POLR2A PRPF8

3.93e-04126394M39406
PathwayREACTOME_HIV_INFECTION

VPS37A PDCD6IP SUPT5H POLR2A TSG101

4.14e-04231395M12469
PathwayWP_NEUROGENESIS_REGULATION_IN_THE_OLFACTORY_EPITHELIUM

NEUROD1 NUMBL NUMB

5.17e-0457393M48326
PathwayWP_ENDODERM_DIFFERENTIATION

EOMES SOX7 FOXA2 PABPC1

6.34e-04143394M39591
PathwayREACTOME_SIGNALING_BY_FGFR_IN_DISEASE

POLR2A CNTRL BAG4

6.93e-0463393M635
PathwayREACTOME_ASSEMBLY_OF_THE_HIV_VIRION

VPS37A TSG101

8.73e-0416392M27033
PathwayREACTOME_FORMATION_OF_DEFINITIVE_ENDODERM

EOMES FOXA2

9.88e-0417392M48030
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIBES_SNRNA_GENES

SRRT SUPT5H POLR2A

1.07e-0373393MM15349
PathwayWP_INHIBITION_OF_EXOSOME_BIOGENESIS_AND_SECRETION_BY_MANUMYCIN_A_IN_CRPC_CELLS

PDCD6IP HGS

1.11e-0318392M39737
PathwayREACTOME_METABOLISM_OF_RNA

SRRT CASC3 XRN2 SUPT5H POLR2A PRPF8 PABPC1

1.29e-03612397MM15547
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIBES_SNRNA_GENES

SRRT SUPT5H POLR2A

1.44e-0381393M27647
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS

NEUROD1 FOXA2

1.52e-0321392M14966
PathwayKEGG_ENDOCYTOSIS

VPS37A PDCD6IP HGS TSG101

1.52e-03181394M1519
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-6 ERVK-8 ERVK-5 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-24

1.27e-139464921542922
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-6 ERVK-7 ERVK-10 ERVK-24

1.04e-11464410469592
Pubmed

Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.

ERVK-6 ERVK-5 ERVK-19 ERVK-10

1.04e-1146447983737
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-6 ERVK-8 ERVK-19 ERVK-21 ERVK-9

1.41e-111264514557543
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-19 ERVK-7 ERVK-21

5.20e-11564412629516
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

WBP2 SRRT CASC3 XRN2 ARID1B VPS37A PDCD6IP SUPT5H FUBP1 POLR2A BAG4 SEC16A TSG101 PRPF8 PABPC1

9.54e-11922641527609421
Pubmed

Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding.

VPS37A PDCD6IP HGS TSG101

3.63e-10764415509564
Pubmed

Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2DeltaGF122) and structural roles of F122 in target recognition.

PDCD6IP ANXA7 TSG101 SEC31A

3.63e-10764420691033
Pubmed

Proline-rich sequence recognition: II. Proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactions.

PDCD6IP HGS SEC16A TSG101 PABPC1

3.49e-093264519542561
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

WBP2 MIA2 PDCD6IP TULP4 NFATC4 LITAF NUMB TSG101 LMTK3 PABPC1

6.28e-09430641035044719
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

SRRT NCOA3 XRN2 ARID1B FUBP1 SMARCD2 ECPAS PRPF8

7.37e-0922064835785414
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

SRRT SETD2 XRN2 ARID1B PDCD6IP NUMBL SUPT5H ANXA7 POLR2A TSG101 SSBP2 SEC31A LMTK3 PRPF8

8.23e-091082641438697112
Pubmed

Ultrastructural analysis of ESCRT proteins suggests a role for endosome-associated tubular-vesicular membranes in ESCRT function.

PDCD6IP HGS TSG101

2.37e-08464317014699
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-21 ERVK-9 ERVK-10 ERVK-24

3.13e-081864418664271
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

SRRT NCOA3 SETD2 XRN2 PDCD6IP ANAPC1 SUPT5H FUBP1 ANXA7 POLR2A SMARCD2 ECPAS PRPF8

3.38e-081014641332416067
Pubmed

Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor.

ARID1B PDCD6IP SEC16A TSG101 SEC31A

3.58e-085064527716508
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

SRRT CASC3 NCOA3 SETD2 VPS37A NUMBL POLR2A SEC16A NUMB PABPC1L TSG101 SEC31A PABPC1

4.44e-081038641326673895
Pubmed

Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking.

PDCD6IP HGS TSG101

5.93e-08564317229889
Pubmed

Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.

ERVK-6 ERVK-5 ERVK-7

5.93e-08564311401426
Pubmed

The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation.

VPS37A HGS TSG101

5.93e-08564315240819
Pubmed

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles.

PDCD6IP HGS TSG101

5.93e-08564324105262
Pubmed

Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.

VPS37A PDCD6IP HGS SEC16A TSG101

9.09e-086064534761192
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

SRRT SETD2 XRN2 ARID1B ANAPC1 SUPT5H POLR2A SEC16A SMARCD2

1.14e-0744064934244565
Pubmed

TANGO1 recruits Sec16 to coordinately organize ER exit sites for efficient secretion.

MIA2 SEC16A SEC31A

1.18e-07664328442536
Pubmed

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

ERVK-6 ERVK-19 ERVK-9

1.18e-07664315063128
Pubmed

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.

WBP2 ARID1B FAM168A TULP4 SUPT5H POLR2A SMARCD2 TSG101 PRPF8 PABPC1

1.79e-07615641031048545
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

ARID1B PDCD6IP POLR2A HGS SEC16A NUMB SEC31A CRYBG3 ECPAS

2.06e-0747264938943005
Pubmed

Membrane budding and scission by the ESCRT machinery: it's all in the neck.

VPS37A PDCD6IP HGS TSG101

2.39e-072964420588296
Pubmed

The penta-EF-hand protein ALG-2 interacts directly with the ESCRT-I component TSG101, and Ca2+-dependently co-localizes to aberrant endosomes with dominant-negative AAA ATPase SKD1/Vps4B.

VPS37A PDCD6IP TSG101

4.95e-07964316004603
Pubmed

Global proteomics of Ubqln2-based murine models of ALS.

WBP2 VPS37A PDCD6IP ANXA7 HGS BAG4 TSG101

5.34e-0726164733277362
Pubmed

DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.

SRRT XRN2 POLR2A PRPF8 PABPC1

6.63e-078964522446626
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

SOX7 NCOA3 ARID1B PDCD6IP SUPT5H ANXA7 SEC16A SMARCD2

6.94e-0739864835016035
Pubmed

The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding.

VPS37A HGS TSG101

7.07e-071064315218037
Pubmed

Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.

ERVK-6 ERVK-19 ERVK-21

7.07e-071064312970426
Pubmed

Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion.

PDCD6IP HGS SEC31A

9.70e-071164329604273
Pubmed

Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.

PDCD6IP HGS TSG101

1.68e-061364317853893
Pubmed

The structural biology of HIV-1: mechanistic and therapeutic insights.

PDCD6IP POLR2A TSG101

1.68e-061364322421880
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

SRRT CASC3 XRN2 SUPT5H FUBP1 ANXA7 POLR2A BAG4 PRPF8 PABPC1

2.09e-06807641022681889
Pubmed

A protein interaction landscape of breast cancer.

XRN2 ARID1B SUPT5H FUBP1 POLR2A HGS SMARCD2 SEC31A ECPAS

2.37e-0663464934591612
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

XRN2 PDCD6IP ANAPC1 SUPT5H POLR2A SEC16A ECPAS PRPF8 PABPC1

3.01e-0665364922586326
Pubmed

Numblike and Numb differentially affect p53 and Sonic Hedgehog signaling.

NUMBL NUMB

3.33e-06264221893032
Pubmed

The C-terminal portion of the Hrs protein interacts with Tsg101 and interferes with human immunodeficiency virus type 1 Gag particle production.

HGS TSG101

3.33e-06264217182674
Pubmed

Peptide inhibitors of HIV-1 egress.

PDCD6IP TSG101

3.33e-06264219099395
Pubmed

EGFR Signaling Termination via Numb Trafficking in Ependymal Progenitors Controls Postnatal Neurogenic Niche Differentiation.

NUMBL NUMB

3.33e-06264231433979
Pubmed

Depletion of Numb and Numblike in Murine Lung Epithelial Cells Ameliorates Bleomycin-Induced Lung Fibrosis by Inhibiting the β-Catenin Signaling Pathway.

NUMBL NUMB

3.33e-06264234124033
Pubmed

Three-dimensional analysis of budding sites and released virus suggests a revised model for HIV-1 morphogenesis.

PDCD6IP TSG101

3.33e-06264219064259
Pubmed

Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes.

HGS TSG101

3.33e-06264212900395
Pubmed

HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein.

HGS TSG101

3.33e-06264212900394
Pubmed

Tsg101 and Alix interact with murine leukemia virus Gag and cooperate with Nedd4 ubiquitin ligases during budding.

PDCD6IP TSG101

3.33e-06264215908698
Pubmed

Distinct roles for Tsg101 and Hrs in multivesicular body formation and inward vesiculation.

HGS TSG101

3.33e-06264216707569
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

3.33e-0626429060628
Pubmed

Numb and Numbl act to determine mammary myoepithelial cell fate, maintain epithelial identity, and support lactogenesis.

NUMBL NUMB

3.33e-06264227383182
Pubmed

Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

ERVK-6 ERVK-19

3.33e-0626429460924
Pubmed

Numb and Numblike regulate sarcomere assembly and maintenance.

NUMBL NUMB

3.33e-06264235104799
Pubmed

HIV-1 Gag release from yeast reveals ESCRT interaction with the Gag N-terminal protein region.

PDCD6IP TSG101

3.33e-06264232994219
Pubmed

Herpes simplex virus type 1 production requires a functional ESCRT-III complex but is independent of TSG101 and ALIX expression.

PDCD6IP TSG101

3.33e-06264219692479
Pubmed

Normal hemopoiesis and lymphopoiesis in the combined absence of numb and numblike.

NUMBL NUMB

3.33e-06264217513721
Pubmed

Crystallographic and functional analysis of the ESCRT-I /HIV-1 Gag PTAP interaction.

HGS TSG101

3.33e-06264221070952
Pubmed

Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1.

SETD2 POLR2A

3.33e-06264216314571
Pubmed

[HIV-1 infection affects the expression of host cell factor TSG101 and Alix].

PDCD6IP TSG101

3.33e-06264221528537
Pubmed

Regulation of vascular endothelial growth factor receptor function in angiogenesis by numb and numb-like.

NUMBL NUMB

3.33e-06264226069237
Pubmed

SPT5 stabilization of promoter-proximal RNA polymerase II.

SUPT5H POLR2A

3.33e-06264234480849
Pubmed

Solution structure of the human immunodeficiency virus type 1 p6 protein.

PDCD6IP TSG101

3.33e-06264216234236
Pubmed

Variability in the P6gag domains of HIV-1 involved in viral budding.

PDCD6IP TSG101

3.33e-06264216470130
Pubmed

The nucleocapsid region of HIV-1 Gag cooperates with the PTAP and LYPXnL late domains to recruit the cellular machinery necessary for viral budding.

PDCD6IP TSG101

3.33e-06264219282983
Pubmed

Numb deficiency causes impaired trafficking of mGlu5 in neurons and autistic-like behaviors.

NUMBL NUMB

3.33e-06264231129078
Pubmed

Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.

PDCD6IP HGS TSG101

4.75e-061864314519844
Pubmed

The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.

CASC3 XRN2 PABPC1

4.75e-061864325220460
Pubmed

Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners.

WBP2 PDCD6IP POLR2A HGS

5.37e-066264426508657
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

PDCD6IP NUMBL HGS SEC16A NUMB SEC31A CRYBG3 ECPAS PABPC1

5.79e-0670864939231216
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

WBP2 XRN2 PDCD6IP SUPT5H ANXA7 SEC16A NUMB SEC31A ECPAS PRPF8 PABPC1 MMUT

6.41e-061367641232687490
Pubmed

Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development.

EOMES ARID1B NEUROD1 SMARCD2

6.49e-066564426655900
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

SRRT SETD2 SUPT5H FUBP1 SEC16A SEC31A PABPC1

8.78e-0639964735987950
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

SRRT SETD2 XRN2 ARID1B FAM168A FUBP1 POLR2A SEC16A PRPF8 PABPC1

9.11e-06954641036373674
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

SETD2 PDCD6IP FUBP1 POLR2A CNTRL SEC16A SEC31A ECPAS PRPF8

9.58e-0675464935906200
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

SRRT XRN2 PDCD6IP ANAPC1 SUPT5H FUBP1 POLR2A TSG101 SEC31A ECPAS PRPF8 PABPC1

9.74e-061425641230948266
Pubmed

Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding.

PDCD6IP TSG101

9.99e-06364217350572
Pubmed

Embryonic Poly(A)-Binding Protein Is Required During Early Stages of Mouse Oocyte Development for Chromatin Organization, Transcriptional Silencing, and Meiotic Competence.

PABPC1L PABPC1

9.99e-06364226134869
Pubmed

ARS2/SRRT: at the nexus of RNA polymerase II transcription, transcript maturation and quality control.

SRRT POLR2A

9.99e-06364234060620
Pubmed

Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101.

HGS TSG101

9.99e-06364219808888
Pubmed

Structure and function of the human transcription elongation factor DSIF.

SUPT5H POLR2A

9.99e-06364210075709
Pubmed

Superovulation alters embryonic poly(A)-binding protein (Epab) and poly(A)-binding protein, cytoplasmic 1 (Pabpc1) gene expression in mouse oocytes and early embryos.

PABPC1L PABPC1

9.99e-06364225034140
Pubmed

Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain.

NUMBL NUMB

9.99e-06364210551880
Pubmed

Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase.

SETD2 POLR2A

9.99e-06364216118227
Pubmed

Epab is dispensable for mouse spermatogenesis and male fertility.

PABPC1L PABPC1

9.99e-06364224599567
Pubmed

Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery.

PDCD6IP TSG101

9.99e-06364217556548
Pubmed

Proline-rich domain of human ALIX contains multiple TSG101-UEV interaction sites and forms phosphorylation-mediated reversible amyloids.

PDCD6IP TSG101

9.99e-06364232917811
Pubmed

Numb regulates the polarized delivery of cyclic nucleotide-gated ion channels in rod photoreceptor cilia.

NUMBL NUMB

9.99e-06364225319694
Pubmed

Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.

ERVK-6 ERVK-19

9.99e-06364210516026
Pubmed

SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease.

LITAF TSG101

9.99e-06364216118794
Pubmed

The poly(A)-binding protein genes, EPAB, PABPC1, and PABPC3 are differentially expressed in infertile men with non-obstructive azoospermia.

PABPC1L PABPC1

9.99e-06364226843391
Pubmed

Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.

ERVK-6 ERVK-9

9.99e-0636429971820
Pubmed

Human nuclear Dicer restricts the deleterious accumulation of endogenous double-stranded RNA.

SUPT5H POLR2A

9.99e-06364224814348
Pubmed

TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation.

HGS TSG101

9.99e-06364212802020
Pubmed

VPS37A directs ESCRT recruitment for phagophore closure.

VPS37A TSG101

9.99e-06364231519728
Pubmed

The Notch regulator Numb links the Notch and TCR signaling pathways.

NUMBL NUMB

9.99e-06364215634911
Pubmed

Numb links extracellular cues to intracellular polarity machinery to promote chemotaxis.

NUMBL NUMB

9.99e-06364221571219
Pubmed

Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites.

XRN2 POLR2A

9.99e-06364215565158
Pubmed

Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction.

SUPT5H POLR2A

9.99e-06364218197258
Pubmed

HIV Gag polyprotein: processing and early viral particle assembly.

PDCD6IP TSG101

9.99e-06364223266279
InteractionPDCD6 interactions

ARID1B MIA2 PDCD6IP MAPK1IP1L FUBP1 ANXA7 BAG4 SEC16A TSG101 SEC31A PABPC1

1.07e-112045711int:PDCD6
InteractionVPS37C interactions

PDCD6IP FAM168A KLF1 MAPK1IP1L FUBP1 HGS BAG4 DAZAP2 TSG101

2.10e-10141579int:VPS37C
InteractionFAM168A interactions

WBP2 ARID1B FAM168A TULP4 POLR2A HGS DAZAP2 SMARCD2

6.15e-09142578int:FAM168A
InteractionWWP2 interactions

WBP2 XRN2 ARID1B PDCD6IP FAM168A TULP4 LITAF SUPT5H POLR2A HGS BAG4 SMARCD2 TSG101 PRPF8 PABPC1

7.55e-098405715int:WWP2
InteractionSS18L1 interactions

ARID1B MIA2 FAM168A MAPK1IP1L HGS BAG4 SMARCD2

1.12e-0898577int:SS18L1
InteractionPEF1 interactions

PDCD6IP FAM168A HGS BAG4 SEC16A DAZAP2 SEC31A

2.21e-08108577int:PEF1
InteractionTNIP2 interactions

WBP2 SRRT CASC3 XRN2 ARID1B VPS37A PDCD6IP SUPT5H FUBP1 POLR2A BAG4 SEC16A TSG101 PRPF8 PABPC1

3.99e-089525715int:TNIP2
InteractionWWOX interactions

WBP2 VOPP1 XRN2 DMRT3 PDCD6IP LITAF POLR2A DAZAP2 TSG101 PRPF8 PABPC1 SHC3

1.46e-076275712int:WWOX
InteractionALG2 interactions

VPS37A SHISA5 ANXA7 TSG101 SEC31A

1.51e-0744575int:ALG2
InteractionNEDD4 interactions

WBP2 VOPP1 PDCD6IP TULP4 LITAF POLR2A HGS NUMB DAZAP2 TSG101 PRPF8

3.00e-075445711int:NEDD4
InteractionKRTAP19-5 interactions

PLSCR4 DMRT3 FAM168A MAPK1IP1L HGS DAZAP2

3.57e-0799576int:KRTAP19-5
InteractionSNRPC interactions

SRRT SETD2 FAM168A KLF1 SUPT5H FUBP1 POLR2A BAG4 DAZAP2 PRPF8

3.84e-074405710int:SNRPC
InteractionTIAL1 interactions

NCOA3 FAM168A KLF1 MAPK1IP1L FUBP1 DAZAP2 PABPC1

5.39e-07172577int:TIAL1
InteractionPPIA interactions

ARID1B PDCD6IP SUPT5H ANXA7 POLR2A HGS SEC16A NUMB SMARCD2 SEC31A CRYBG3 ECPAS PRPF8

8.74e-078885713int:PPIA
InteractionSMAP2 interactions

FAM168A NUMBL HGS SEC16A NUMB DAZAP2 PABPC1

1.02e-06189577int:SMAP2
InteractionBAG3 interactions

WBP2 PDCD6IP FAM168A TULP4 LITAF BAG4 SEC16A DAZAP2 SSBP2 PRPF8 PABPC1

1.31e-066325711int:BAG3
InteractionARRDC1 interactions

VPS37A PDCD6IP FAM168A POLR2A TSG101

1.38e-0668575int:ARRDC1
InteractionMECP2 interactions

SRRT SETD2 XRN2 ARID1B PDCD6IP NUMBL SUPT5H ANXA7 POLR2A SMARCD2 TSG101 SSBP2 SEC31A LMTK3 PRPF8

1.91e-0612875715int:MECP2
InteractionTSG101 interactions

VPS37A PDCD6IP LITAF HGS BAG4 SEC16A TSG101 PABPC1

2.08e-06303578int:TSG101
InteractionAR interactions

SRRT NCOA3 XRN2 ARID1B FUBP1 SEC16A SMARCD2 TSG101 SSBP2 ECPAS PRPF8 PABPC1 SHC3

2.99e-069925713int:AR
InteractionTRIM33 interactions

SOX7 NCOA3 ARID1B PDCD6IP ANAPC1 FUBP1 SSBP2 PRPF8 PABPC1

4.68e-06453579int:TRIM33
InteractionEP300 interactions

SRRT CASC3 SOX7 NCOA3 XRN2 NEUROD1 KLF1 SUPT5H POLR2A TSG101 SSBP2 SEC31A ECPAS PRPF8 PABPC1

5.43e-0614015715int:EP300
InteractionTOLLIP interactions

WBP2 XRN2 PDCD6IP FAM168A HGS DAZAP2 TSG101 ECPAS

7.09e-06358578int:TOLLIP
InteractionCEP55 interactions

MIA2 PDCD6IP SUPT5H MAPK1IP1L HGS BAG4 TSG101

7.56e-06256577int:CEP55
InteractionMAPK1IP1L interactions

MAPK1IP1L FUBP1 HGS DAZAP2

7.86e-0645574int:MAPK1IP1L
InteractionTFG interactions

PDCD6IP FAM168A MAPK1IP1L HGS DAZAP2 TSG101 SEC31A

7.96e-06258577int:TFG
InteractionYAP1 interactions

WBP2 SETD2 XRN2 ARID1B TULP4 ANAPC1 FUBP1 POLR2A BAG4 SEC16A NUMB PRPF8 PABPC1

8.77e-0610955713int:YAP1
InteractionSIRT6 interactions

SRRT SETD2 XRN2 ARID1B ANAPC1 SUPT5H POLR2A SEC16A SMARCD2 PRPF8

9.26e-066285710int:SIRT6
InteractionARID1B interactions

SOX7 NCOA3 ARID1B FAM168A SUPT5H SMARCD2

1.06e-05177576int:ARID1B
InteractionHNRNPD interactions

FNDC3B NCOA3 SHISA5 FUBP1 POLR2A SMARCD2 SEC31A ECPAS PRPF8 PABPC1

1.06e-056385710int:HNRNPD
InteractionLHX1 interactions

ARID1B SMARCD2 SSBP2 FOXA2 PABPC1

1.07e-05103575int:LHX1
InteractionTOM1 interactions

LITAF HGS DAZAP2 TSG101 SSBP2

1.12e-05104575int:TOM1
InteractionSMARCC1 interactions

SOX7 NCOA3 ARID1B KLF1 FUBP1 POLR2A SMARCD2 PRPF8

1.18e-05384578int:SMARCC1
InteractionUBQLN2 interactions

WBP2 VPS37A PDCD6IP FAM168A LITAF ANXA7 HGS BAG4 DAZAP2 TSG101 PABPC1

1.21e-057975711int:UBQLN2
InteractionALG13 interactions

PLSCR4 NCOA3 ARID1B BAG4 SEC16A PABPC1

1.28e-05183576int:ALG13
InteractionTEKT5 interactions

PLSCR4 FNDC3B HGS BAG4

1.30e-0551574int:TEKT5
InteractionDAZAP2 interactions

PLSCR4 FAM168A LITAF MAPK1IP1L HGS DAZAP2

1.40e-05186576int:DAZAP2
InteractionPAX8 interactions

WBP2 NCOA3 ARID1B ANXA7 SMARCD2

1.54e-05111575int:PAX8
InteractionKRT18 interactions

WBP2 XRN2 HGS SEC16A TSG101 CRYBG3 PRPF8 PABPC1

2.21e-05419578int:KRT18
InteractionUBA52 interactions

PLSCR4 WBP2 FNDC3B FAM168A LITAF HGS DAZAP2 TSG101

2.99e-05437578int:UBA52
InteractionTLE1 interactions

PLSCR4 SOX7 FUBP1 ANXA7 DAZAP2 FOXA2

3.01e-05213576int:TLE1
InteractionRUNX1 interactions

WBP2 XRN2 FUBP1 HGS BAG4 DAZAP2 PABPC1

3.45e-05324577int:RUNX1
InteractionYPEL3 interactions

PLSCR4 FNDC3B DMRT3 HGS SHC3

3.69e-05133575int:YPEL3
InteractionERG interactions

NCOA3 XRN2 ARID1B POLR2A SMARCD2 PRPF8

3.89e-05223576int:ERG
InteractionGCM1 interactions

NCOA3 ARID1B SMARCD2 PABPC1L

4.09e-0568574int:GCM1
InteractionCREBBP interactions

SOX7 NCOA3 ARID1B NEUROD1 KLF1 NFATC4 ANXA7 POLR2A CNTRL

4.29e-05599579int:CREBBP
InteractionETV4 interactions

NCOA3 ARID1B SEC16A SMARCD2

4.33e-0569574int:ETV4
InteractionHSF1 interactions

XRN2 PDCD6IP FUBP1 POLR2A BAG4 SEC16A SEC31A PRPF8 PABPC1

4.88e-05609579int:HSF1
InteractionPLEKHB2 interactions

FAM168A SYNGR1 HGS DAZAP2

5.13e-0572574int:PLEKHB2
InteractionNOTCH1 interactions

SRRT NUMBL ANAPC1 HGS NUMB DAZAP2 PRPF8

5.14e-05345577int:NOTCH1
InteractionMOV10 interactions

XRN2 FAM168A ANAPC1 SUPT5H FUBP1 ANXA7 POLR2A HGS BAG4 TSG101 SEC31A PABPC1 TMBIM1

5.23e-0512975713int:MOV10
InteractionDAZL interactions

CASC3 FNDC3B FUBP1 DAZAP2 PABPC1

5.58e-05145575int:DAZL
InteractionSMARCC2 interactions

SOX7 NCOA3 ARID1B KLF1 FUBP1 POLR2A SMARCD2

5.94e-05353577int:SMARCC2
InteractionSTAM2 interactions

LITAF HGS DAZAP2 TSG101 SEC31A

5.95e-05147575int:STAM2
InteractionSNRPA interactions

SRRT SETD2 SUPT5H FUBP1 POLR2A BAG4 PRPF8 PABPC1

5.97e-05482578int:SNRPA
InteractionITCH interactions

WBP2 PDCD6IP LITAF POLR2A HGS NUMB PABPC1

6.26e-05356577int:ITCH
InteractionLITAF interactions

LITAF HGS DAZAP2 TSG101

6.67e-0577574int:LITAF
InteractionVIM interactions

WBP2 SRRT FUBP1 ANXA7 CNTRL HGS BAG4 NUMB SSBP2 PRPF8

7.61e-058045710int:VIM
InteractionRAMAC interactions

PLSCR4 MAPK1IP1L BAG4 DAZAP2

8.53e-0582574int:RAMAC
InteractionSOX7 interactions

SOX7 NCOA3 ARID1B SMARCD2

8.53e-0582574int:SOX7
InteractionKLF4 interactions

NCOA3 ARID1B HGS SMARCD2 PABPC1

8.89e-05160575int:KLF4
InteractionWWP1 interactions

WBP2 FNDC3B FAM168A LITAF POLR2A DAZAP2

9.10e-05260576int:WWP1
InteractionPIN1 interactions

NCOA3 SUPT5H FUBP1 POLR2A SSBP2 PRPF8 PABPC1

9.89e-05383577int:PIN1
InteractionDCP1A interactions

HGS BAG4 SEC16A TSG101 PABPC1

1.06e-04166575int:DCP1A
InteractionCPSF6 interactions

SRRT SETD2 XRN2 FAM168A SUPT5H POLR2A PRPF8 PABPC1

1.10e-04526578int:CPSF6
InteractionUBAP2 interactions

FNDC3B HGS DAZAP2 PABPC1 SHC3

1.18e-04170575int:UBAP2
InteractionTP53BP1 interactions

SRRT NCOA3 ARID1B ANAPC1 FUBP1 ANXA7 HGS SMARCD2

1.20e-04533578int:TP53BP1
InteractionFOXI1 interactions

NCOA3 ARID1B HGS SMARCD2

1.34e-0492574int:FOXI1
InteractionVPS37A interactions

VPS37A HGS TSG101

1.43e-0436573int:VPS37A
InteractionKCNA3 interactions

PDCD6IP NUMBL HGS SEC16A NUMB SEC31A CRYBG3 ECPAS PABPC1 SHC3

1.47e-048715710int:KCNA3
InteractionSNIP1 interactions

SRRT CASC3 XRN2 ARID1B POLR2A SMARCD2 PRPF8

1.67e-04417577int:SNIP1
InteractionEPN2 interactions

WBP2 FAM168A LITAF DAZAP2

1.77e-0499574int:EPN2
InteractionWWTR1 interactions

WBP2 SETD2 ARID1B ANAPC1 POLR2A SEC16A NUMB

1.80e-04422577int:WWTR1
InteractionKRTAP6-2 interactions

PLSCR4 CASC3 DMRT3 FAM168A DAZAP2

1.85e-04187575int:KRTAP6-2
InteractionNUP35 interactions

FNDC3B NCOA3 ARID1B PDCD6IP FUBP1 SEC16A FOXA2

1.85e-04424577int:NUP35
InteractionINTS11 interactions

PLSCR4 SUPT5H ANXA7 POLR2A

1.91e-04101574int:INTS11
InteractionSRP9 interactions

SRRT CASC3 ANAPC1 POLR2A CNTRL PRPF8 PABPC1

1.94e-04427577int:SRP9
InteractionC1orf94 interactions

FAM168A MAPK1IP1L HGS DAZAP2

2.06e-04103574int:C1orf94
InteractionEBAG9 interactions

NCOA3 POLR2A HGS SEC16A NUMB SEC31A

2.09e-04303576int:EBAG9
InteractionTFF1 interactions

NCOA3 POLR2A TSG101

2.12e-0441573int:TFF1
InteractionSP7 interactions

SRRT NCOA3 XRN2 ARID1B FUBP1 SMARCD2

2.13e-04304576int:SP7
InteractionZFYVE16 interactions

VPS37A PDCD6IP HGS TSG101

2.14e-04104574int:ZFYVE16
InteractionSIRT7 interactions

XRN2 PDCD6IP ANAPC1 SUPT5H POLR2A SEC16A ECPAS PRPF8 PABPC1

2.23e-04744579int:SIRT7
InteractionKLF5 interactions

NCOA3 XRN2 ARID1B SEC16A SMARCD2

2.24e-04195575int:KLF5
InteractionLGALS9 interactions

PDCD6IP ANXA7 HGS DAZAP2 TSG101 SEC31A PRPF8 PABPC1

2.35e-04588578int:LGALS9
InteractionPSMA3 interactions

SRRT FNDC3B NCOA3 XRN2 DMRT3 MIA2 NUMBL

2.42e-04443577int:PSMA3
InteractionTLE5 interactions

DMRT3 MIA2 KLF1 SUPT5H HGS BAG4 DAZAP2

2.42e-04443577int:TLE5
InteractionCFAP68 interactions

PLSCR4 DMRT3 HGS

2.44e-0443573int:CFAP68
InteractionRAB9A interactions

NUMBL CNTRL HGS SEC16A NUMB TSG101 CRYBG3 ECPAS

2.54e-04595578int:RAB9A
InteractionKRT35 interactions

DMRT3 HGS TSG101 SHC3

2.75e-04111574int:KRT35
InteractionNEDD4L interactions

WBP2 PDCD6IP LITAF HGS DAZAP2 FOXA2

2.81e-04320576int:NEDD4L
InteractionGLDC interactions

SRRT XRN2 FUBP1 BAG4 SEC16A PABPC1

2.86e-04321576int:GLDC
InteractionSEC24C interactions

MIA2 SUPT5H CNTRL SEC16A SEC31A

2.96e-04207575int:SEC24C
InteractionMKRN3 interactions

MIA2 KLF1 HGS TSG101 PABPC1

3.16e-04210575int:MKRN3
InteractionNXF1 interactions

CASC3 XRN2 ANAPC1 SUPT5H ANXA7 POLR2A HGS BAG4 TSG101 SEC31A PRPF8 TMBIM1

3.17e-0413455712int:NXF1
InteractionKRTAP19-1 interactions

PLSCR4 FAM168A DAZAP2

3.18e-0447573int:KRTAP19-1
InteractionIWS1 interactions

SETD2 XRN2 SUPT5H POLR2A

3.25e-04116574int:IWS1
InteractionTBXT interactions

NCOA3 ARID1B SMARCD2 SSBP2

3.25e-04116574int:TBXT
InteractionNR4A1 interactions

NCOA3 NEUROD1 BAG4 SMARCD2 PABPC1

3.30e-04212575int:NR4A1
InteractionDTX2 interactions

NCOA3 FAM168A HGS SEC16A NUMB DAZAP2

3.31e-04330576int:DTX2
Cytoband17q25

WBP2 HGS

1.33e-033963217q25
Cytoband8p22

SOX7 VPS37A

1.40e-03406328p22
GeneFamilyESCRT-I

VPS37A TSG101

1.15e-0493321116
GeneFamilyAtaxins|Trinucleotide repeat containing

NCOA3 NUMBL

9.44e-0425332775
GeneFamilyBasic helix-loop-helix proteins

NCOA3 NEUROD1

1.71e-02110332420
CoexpressionGSE3920_IFNA_VS_IFNB_TREATED_ENDOTHELIAL_CELL_DN

PLSCR4 EOMES VOPP1 SEC16A TMBIM1

2.36e-05166545M6701
CoexpressionGSE25088_WT_VS_STAT6_KO_MACROPHAGE_ROSIGLITAZONE_STIM_UP

XRN2 FAM168A TULP4 SEC16A NUMB

4.97e-05194545M8019
CoexpressionGSE5099_UNSTIM_VS_MCSF_TREATED_MONOCYTE_DAY3_UP

FNDC3B ARID1B ANAPC1 MAPK1IP1L MMUT

5.61e-05199545M6581
CoexpressionGSE43955_TH0_VS_TGFB_IL6_IL23_TH17_ACT_CD4_TCELL_60H_DN

SRRT TULP4 LITAF SMARCD2 TMBIM1

5.74e-05200545M9688
CoexpressionGSE9006_HEALTHY_VS_TYPE_1_DIABETES_PBMC_4MONTH_POST_DX_UP

MAPK1IP1L DAZAP2 SEC31A ECPAS PABPC1

5.74e-05200545M5779
CoexpressionTABULA_MURIS_SENIS_MESENTERIC_ADIPOSE_TISSUE_MESENCHYMAL_STEM_CELL_OF_ADIPOSE_AGEING

WBP2 NCOA3 NUMBL LITAF SHISA5 MAPK1IP1L POLR2A PABPC1

7.52e-05685548MM3782
Drugp-xylene

PLSCR4 PDCD6IP SHISA5 ANXA7 TSG101

7.75e-0845555CID000007809
Drugaa 288

NUMBL NUMB

5.73e-062552CID002724650
Diseasetotal blood protein measurement

EOMES NCOA3 SETD2 MEF2B SYNGR1 SEC16A

1.85e-04449556EFO_0004536
Diseasecorneal hysteresis

FNDC3B ANAPC1

6.34e-0420552EFO_0010066
Diseasebrain cancer (implicated_via_orthology)

NUMBL NUMB

1.08e-0326552DOID:1319 (implicated_via_orthology)
Diseasehemoglobin A1 measurement

EOMES SOX7 FNDC3B SETD2 TULP4

2.81e-03520555EFO_0007629
DiseaseMalignant neoplasm of breast

EOMES FNDC3B NCOA3 SETD2 ARID1B MIA2 PABPC1

3.67e-031074557C0006142
DiseaseLeukemia, Myelocytic, Acute

SETD2 VOPP1 SYNGR1

4.16e-03173553C0023467
Diseasemean corpuscular hemoglobin concentration

SOX7 FNDC3B XRN2 KLF1 POLR2A SEC16A PABPC1

4.29e-031105557EFO_0004528
Diseaseleukemia

NCOA3 SETD2

4.76e-0355552C0023418
Diseasebreast cancer (is_marker_for)

FUBP1 ANXA7 TSG101

5.01e-03185553DOID:1612 (is_marker_for)
Diseaseovarian cancer (is_marker_for)

ANXA7 TSG101

7.18e-0368552DOID:2394 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
QNPGMTLPHYPYGDG

BAG4

211

O95429
NGARYPYGSMLPPGG

EOMES

181

O95936
PYGSMLPPGGFPAAV

EOMES

186

O95936
VVYGPPPAGAPMVYG

CNTRL

1281

Q7Z7A1
YEGYPAPAMPDFQPG

CRYBG3

1941

Q68DQ2
MPYPYQNRQGPGGPT

ARID1B

1541

Q8NFD5
QYPYPSGFPPMGGGA

ANXA7

31

P20073
SGFPPMGGGAYPQVP

ANXA7

36

P20073
MGGGAYPQVPSSGYP

ANXA7

41

P20073
PLPGGFPGGQMPSQY

ANXA7

121

P20073
MPSQYPGGQPTYPSQ

ANXA7

131

P20073
MQPPFVPAYPGLGYP

NUMBL

486

Q9Y6R0
VINPYQPAPPSGYFM

PABPC1

396

P11940
PDGKGMNPPSYYTQP

LITAF

51

Q99732
CLKGEGMPPYPYLPG

ANAPC1

851

Q9H1A4
GMPPYPYLPGICERS

ANAPC1

856

Q9H1A4
GPLGSTIPMAYYPVG

DAZAP2

81

Q15038
AYVPPGLMPGYQGHV

FAM166C

16

A6NJV1
GYGHPAGYPQPMPPT

TMBIM1

46

Q969X1
MNPVYSPVQPGAPYG

FAM168A

1

Q92567
GPGTPMGPYNPAPYN

FUBP1

476

Q96AE4
LMGAAAPQYPGRGPP

LMTK3

736

Q96Q04
GSGIPQPPPGMSFYA

ECPAS

211

Q5VYK3
YPGYPGYCQMPMPMG

PDCD6IP

806

Q8WUM4
LPMGYYSPQQPSTFP

PLSCR4

56

Q9NRQ2
MPEPNGLYGGFPFPL

FAT2

4216

Q9NYQ8
MPQPPAQAAYYGCGP

PABPC1L

411

Q4VXU2
YPAAPAMPSPDVVYG

MEF2B

131

Q02080
FPRPGGPMAAMYPNG

DERPC

506

P0CG12
SQYGYPGMPPAPQGR

ERVK-10

226

P87889
SQYGYPGMPPAPQGR

ERVK-19

226

Q9YNA8
SQYGYPGMPPAPQGR

ERVK-21

226

P62683
SQYGYPGMPPAPQGR

ERVK-24

226

P63145
SQYGYPGMPPALQGR

ERVK-5

226

Q9HDB9
SQYGYPGMPPAPQGR

ERVK-6

226

Q7LDI9
SQYGYPGMPPAPQGR

ERVK-7

226

P63130
SQYGYPGMPPAPQGR

ERVK-8

226

P62685
SQYGYPGMPPAPQGR

ERVK-9

226

P63126
SQYGYPGMPPAPQGR

HERVK_113

226

P62684
PYGLLSGYPAMYPAP

KLF1

196

Q13351
GVMNFGNPSYPYAPG

CASC3

626

O15234
SPYLYMGGPVSQPPR

DMRT3

6

Q9NQL9
YYPPVTGPGDMPPQF

FNDC3B

141

Q53EP0
PPGAMFGASRDYFPP

MIA2

1331

Q96PC5
GMGGQYPTPNMPYPS

MAPK1IP1L

156

Q8NDC0
VPAQSYPVANGMPYP

NUMB

506

P49757
EQVMHYPGYGSPMPG

FOXA2

406

Q9Y261
MSPVPGCPPSPAYYS

SOX7

271

Q9BT81
GFFQPFMSPRYPGGP

SSBP2

121

P81877
FGYGMPPLYPQTGPP

NFATC4

741

Q14934
YGQTYPAQGPPMQGG

NCOA3

1111

Q9Y6Q9
YYNSIPSKMPPPGGF

SHC3

341

Q92529
GPSYQGYHTMPPQPG

SHISA5

171

Q8N114
PMAYQASPSPSPVGY

SUPT5H

936

O00267
SQYGYPGMPPAPQGR

ERVK-9

226

P63128
PMGPAGPAAQYQRPG

SMARCD2

61

Q92925
MPYGQPRPPILGYGA

SRRT

796

Q9BXP5
TSYMPGMPGGISPYP

TSG101

161

Q99816
MAGVFPYRGPGNPVP

PRPF8

1

Q6P2Q9
GMGVPYPGSYNNPPL

TULP4

1186

Q9NRJ4
PPYYTDPGGPGMNPV

VOPP1

116

Q96AW1
AAGGPPSGAMPFYNP

SEC16A

2316

O15027
YIPSPGGAMSPSYSP

POLR2A

1581

P24928
PNQYQMLAGPGGYPP

XRN2

906

Q9H0D6
GVYMSQPAPAAGPYP

HGS

606

O14964
YAPYVEPTGPDPAGM

SYNGR1

196

O43759
GYPPGYPMQAYVDPS

SETD2

2166

Q9BYW2
QPYPFGTGGSAMYRP

SEC31A

881

O94979
AFPFPVYNGPMAGVP

PRRT1B

161

A0A1B0GWB2
GMSPYASQGFPFLPP

VPS37A

146

Q8NEZ2
GAYVYPPPVANGMYP

WBP2

151

Q969T9
MDGAMGYVQPPPPPY

WBP2

186

Q969T9
PGVKPFTRGPYPTMY

MMUT

86

P22033
YQSPGLPSPPYGTMD

NEUROD1

221

Q13562