Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	insulin receptor activity	INSR INSRR	7.42e-05	3	100	2	GO:0005009
GeneOntologyBiologicalProcess	cellular response to chemical stress	OXR1 DAPK1 LRRC8D AIFM1 WNT16 TET1 TRPV4 CDK1 NOS3 SOD1	1.24e-05	377	98	10	GO:0062197
GeneOntologyCellularComponent	insulin receptor complex	INSR INSRR	1.32e-04	4	99	2	GO:0005899
GeneOntologyCellularComponent	protein kinase complex	CCNL2 INSR INSRR DAPK1 CCNL1 CDK1	1.59e-04	170	99	6	GO:1902911
GeneOntologyCellularComponent	transferase complex, transferring phosphorus-containing groups	CCNL2 USP22 INSR INSRR DAPK1 EXT2 CCNL1 CDK1	1.93e-04	335	99	8	GO:0061695
GeneOntologyCellularComponent	transferase complex	CCNL2 PRAMEF33 PRAMEF10 KMT2B USP22 INSR INSRR DAPK1 EXT2 PRAMEF17 FBXL7 CCNL1 CDK1	6.11e-04	963	99	13	GO:1990234
Domain	-	ZNF234 ZNF560 ZBTB48 PEG3 ZNF101 ZNF786 ZNF169 ZNF546 ZBTB45 ZBTB21 ZBTB5 ZNF616 PLAGL1 ZNF853 ZNF763 ZNF292	5.32e-07	679	99	16	3.30.160.60
Domain	ZINC_FINGER_C2H2_2	ZNF234 ZNF560 ZBTB48 FOXP2 PEG3 ZNF101 ZNF786 ZNF169 ZNF546 ZBTB45 ZBTB21 ZBTB5 ZNF616 PLAGL1 ZNF853 ZNF763 ZNF292	6.11e-07	775	99	17	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF234 ZNF560 ZBTB48 FOXP2 PEG3 ZNF101 ZNF786 ZNF169 ZNF546 ZBTB45 ZBTB21 ZBTB5 ZNF616 PLAGL1 ZNF853 ZNF763 ZNF292	6.33e-07	777	99	17	PS00028
Domain	zf-C2H2	ZNF234 ZNF560 ZBTB48 PEG3 ZNF101 ZNF786 ZNF169 ZNF546 ZBTB45 ZBTB21 ZBTB5 ZNF616 PLAGL1 ZNF853 ZNF763 ZNF292	6.97e-07	693	99	16	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF234 ZNF560 ZBTB48 PEG3 ZNF101 ZNF786 ZNF169 ZNF546 ZBTB45 ZBTB21 ZBTB5 ZNF616 PLAGL1 ZNF853 ZNF763 ZNF292	7.11e-07	694	99	16	IPR013087
Domain	Znf_C2H2-like	ZNF234 ZNF560 ZBTB48 FOXP2 PEG3 ZNF101 ZNF786 ZNF169 ZNF546 ZBTB45 ZBTB21 ZBTB5 ZNF616 PLAGL1 ZNF853 ZNF763 ZNF292	8.84e-07	796	99	17	IPR015880
Domain	Znf_C2H2	ZNF234 ZNF560 ZBTB48 FOXP2 PEG3 ZNF101 ZNF786 ZNF169 ZNF546 ZBTB45 ZBTB21 ZBTB5 ZNF616 PLAGL1 ZNF853 ZNF763 ZNF292	1.03e-06	805	99	17	IPR007087
Domain	ZnF_C2H2	ZNF234 ZNF560 ZBTB48 FOXP2 PEG3 ZNF101 ZNF786 ZNF169 ZNF546 ZBTB45 ZBTB21 ZBTB5 ZNF616 PLAGL1 ZNF853 ZNF763 ZNF292	1.09e-06	808	99	17	SM00355
Domain	Ank	ESPNL DAPK1 ANKHD1 TRPV4 PLA2G6 RAI14 CAMTA1 HECTD1	2.88e-05	228	99	8	PF00023
Domain	ANK	ESPNL DAPK1 ANKHD1 TRPV4 PLA2G6 RAI14 CAMTA1 HECTD1	5.68e-05	251	99	8	SM00248
Domain	ANK_REPEAT	ESPNL DAPK1 ANKHD1 TRPV4 PLA2G6 RAI14 CAMTA1 HECTD1	6.01e-05	253	99	8	PS50088
Domain	Ankyrin_rpt-contain_dom	ESPNL DAPK1 ANKHD1 TRPV4 PLA2G6 RAI14 CAMTA1 HECTD1	6.18e-05	254	99	8	IPR020683
Domain	ANK_REP_REGION	ESPNL DAPK1 ANKHD1 TRPV4 PLA2G6 RAI14 CAMTA1 HECTD1	6.18e-05	254	99	8	PS50297
Domain	Ankyrin_rpt	ESPNL DAPK1 ANKHD1 TRPV4 PLA2G6 RAI14 CAMTA1 HECTD1	7.67e-05	262	99	8	IPR002110
Domain	Tyr_kinase_insulin-like_rcpt	INSR INSRR	8.32e-05	3	99	2	IPR016246
Domain	zf-C2H2_6	ZNF234 ZNF560 ZBTB48 PEG3 ZNF169 ZNF546 ZNF616 ZNF763	2.65e-04	314	99	8	PF13912
Domain	-	ESPNL DAPK1 TRPV4 PLA2G6 RAI14 CAMTA1 HECTD1	3.53e-04	248	99	7	1.25.40.20
Domain	Furin-like	INSR INSRR	5.74e-04	7	99	2	PF00757
Domain	Rcpt_L-dom	INSR INSRR	5.74e-04	7	99	2	IPR000494
Domain	Furin-like_Cys-rich_dom	INSR INSRR	5.74e-04	7	99	2	IPR006211
Domain	Recep_L_domain	INSR INSRR	5.74e-04	7	99	2	PF01030
Domain	-	INSR INSRR	5.74e-04	7	99	2	3.80.20.20
Domain	KRAB	ZNF234 ZNF560 ZNF101 ZNF786 ZNF169 ZNF546 ZNF616 ZNF763	6.34e-04	358	99	8	PS50805
Domain	KRAB	ZNF234 ZNF560 ZNF101 ZNF786 ZNF169 ZNF546 ZNF616 ZNF763	6.34e-04	358	99	8	PF01352
Domain	Cyclin_L/T	CCNL2 CCNL1	7.63e-04	8	99	2	IPR015429
Domain	Znf-RING_LisH	RNF32 MID2 MID1	7.67e-04	34	99	3	IPR027370
Domain	zf-RING_UBOX	RNF32 MID2 MID1	7.67e-04	34	99	3	PF13445
Domain	KRAB	ZNF234 ZNF560 ZNF101 ZNF786 ZNF169 ZNF546 ZNF616 ZNF763	7.72e-04	369	99	8	SM00349
Domain	KRAB	ZNF234 ZNF560 ZNF101 ZNF786 ZNF169 ZNF546 ZNF616 ZNF763	7.85e-04	370	99	8	IPR001909
Domain	aa-tRNA-synt_IIb	EIF2AK4 HARS1	1.48e-03	11	99	2	IPR002314
Domain	Znf_CXXC	KMT2B TET1	1.48e-03	11	99	2	IPR002857
Domain	ZF_CXXC	KMT2B TET1	1.48e-03	11	99	2	PS51058
Domain	tRNA-synt_2b	EIF2AK4 HARS1	1.48e-03	11	99	2	PF00587
Domain	-	EIF2AK4 HARS1	1.48e-03	11	99	2	3.40.50.800
Domain	zf-CXXC	KMT2B TET1	1.48e-03	11	99	2	PF02008
Domain	Tyr_kinase_rcpt_2_CS	INSR INSRR	1.48e-03	11	99	2	IPR002011
Domain	COS_domain	MID2 MID1	1.77e-03	12	99	2	IPR017903
Domain	RECEPTOR_TYR_KIN_II	INSR INSRR	1.77e-03	12	99	2	PS00239
Domain	COS	MID2 MID1	1.77e-03	12	99	2	PS51262
Domain	Anticodon-bd	EIF2AK4 HARS1	2.43e-03	14	99	2	IPR004154
Domain	-	RNF32 KMT2B USP22 MID2 RNF213 RFPL1 MID1 KDM4A	2.66e-03	449	99	8	3.30.40.10
Domain	Bbox_C	MID2 MID1	2.79e-03	15	99	2	IPR003649
Domain	BBC	MID2 MID1	2.79e-03	15	99	2	SM00502
Domain	Znf_RING/FYVE/PHD	RNF32 KMT2B USP22 MID2 RNF213 RFPL1 MID1 KDM4A	3.05e-03	459	99	8	IPR013083
Domain	Acyltransferase	LPCAT4 TMEM68	3.18e-03	16	99	2	PF01553
Domain	PlsC	LPCAT4 TMEM68	3.59e-03	17	99	2	SM00563
Domain	Cyclin_C	CCNL2 CCNL1	3.59e-03	17	99	2	PF02984
Domain	Cyclin_C-dom	CCNL2 CCNL1	3.59e-03	17	99	2	IPR004367
Domain	Plipid/glycerol_acylTrfase	LPCAT4 TMEM68	3.59e-03	17	99	2	IPR002123
Domain	Cyclin_C	CCNL2 CCNL1	3.59e-03	17	99	2	SM01332
Domain	aa-tRNA-synth_II	EIF2AK4 HARS1	4.03e-03	18	99	2	IPR006195
Domain	Furin_repeat	INSR INSRR	4.03e-03	18	99	2	IPR006212
Domain	PI-PLC-X	PLCXD2 PLCG2	4.03e-03	18	99	2	PF00388
Domain	PLCXc	PLCXD2 PLCG2	4.03e-03	18	99	2	SM00148
Domain	FU	INSR INSRR	4.03e-03	18	99	2	SM00261
Domain	AA_TRNA_LIGASE_II	EIF2AK4 HARS1	4.03e-03	18	99	2	PS50862
Domain	PIPLC_X_DOMAIN	PLCXD2 PLCG2	4.48e-03	19	99	2	PS50007
Domain	PLipase_C_PInositol-sp_X_dom	PLCXD2 PLCG2	4.48e-03	19	99	2	IPR000909
Domain	PRAME_family	PRAMEF10 PRAMEF17	4.48e-03	19	99	2	IPR026271
Domain	BTB	ZBTB48 ZBTB45 ZBTB21 ZBTB5	5.21e-03	131	99	4	PF00651
Pathway	BIOCARTA_RACC_PATHWAY	KCNQ2 TRPV4 NOS3	4.28e-05	15	66	3	M22002
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	TOR1AIP2 CCNL2 PRAMEF10 CCDC185 GALNT2 AADACL3 MRPL37 PSMD4 PRAMEF17 FAM43B LRRC8D UTP25 KDM4A CAMTA1 MTARC1	2.62e-07	1031	100	15	16710414
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZNF234 GALNT2 OXR1 ENPP2 PEG3 PSMD4 FAM120A SERGEF ZBTB5 KCNQ2 RAI14 KDM4A HARS1 HECTD1 SOD1 ZNF292	7.97e-07	1285	100	16	35914814
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	PRAMEF33 PRAMEF10 USP22 OXR1 PRAMEF17 LRRC8D ZP1 FBXL7 AGO3 WNT16 TET1 PLA2G6 CAMKMT KLK5 FTO	2.66e-06	1242	100	15	30973865
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TOR1AIP2 PRAMEF33 PRAMEF10 POC1A PEG3 ZNF101 PRAMEF17 ANKHD1 TET1 CCNL1 ADAMTS18 EIF2AK4 CAMTA1 SOD1	2.75e-06	1084	100	14	11544199
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ANKHD1 FBXL7 TET1 ZBTB21 ZBTB5 RAI14 KDM4A EIF2AK4 NUP93 FTO	3.10e-06	529	100	10	14621295
Pubmed	Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.	PRAMEF33 PRAMEF10 PRAMEF17 PLAGL1	3.15e-06	35	100	4	19389355
Pubmed	Testis determination requires insulin receptor family function in mice.	INSL3 INSR INSRR	6.46e-06	13	100	3	14628051
Pubmed	Preserved pancreatic beta-cell development and function in mice lacking the insulin receptor-related receptor.	INSR INSRR	8.18e-06	2	100	2	11463843
Pubmed	Increased tissue transglutaminase activity contributes to central vascular stiffness in eNOS knockout mice.	TGM2 NOS3	8.18e-06	2	100	2	23873798
Pubmed	TET1 Participates in Complete Freund's Adjuvant-induced Trigeminal Inflammatory Pain by Regulating Kv7.2 in a Mouse Model.	TET1 KCNQ2	8.18e-06	2	100	2	37973721
Pubmed	Recruitment of the m6A/m6Am demethylase FTO to target RNAs by the telomeric zinc finger protein ZBTB48.	ZBTB48 FTO	8.18e-06	2	100	2	39300486
Pubmed	Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma.	TRPV4 NOS3	8.18e-06	2	100	2	33853948
Pubmed	Characterization of a hybrid receptor formed by dimerization of the insulin receptor-related receptor (IRR) with the insulin receptor (IR): coexpression of cDNAs encoding human IRR and human IR in NIH-3T3 cells.	INSR INSRR	8.18e-06	2	100	2	8916919
Pubmed	Mid1/Mid2 expression in craniofacial development and a literature review of X-linked opitz syndrome.	MID2 MID1	8.18e-06	2	100	2	26788540
Pubmed	Nucleoporin 93, a new substrate of the E3 ubiquitin protein ligase HECTD1, promotes esophageal squamous cell carcinoma progression.	NUP93 HECTD1	8.18e-06	2	100	2	37993750
Pubmed	Endothelial TRPV4-eNOS coupling as a vital therapy target for treatment of hypertension.	TRPV4 NOS3	8.18e-06	2	100	2	34822720
Pubmed	The TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivo.	INSR EIF2AK4	2.45e-05	3	100	2	25131199
Pubmed	TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity.	TRPV4 NOS3	2.45e-05	3	100	2	27913210
Pubmed	Dynamic interplay between H-current and M-current controls motoneuron hyperexcitability in amyotrophic lateral sclerosis.	KCNQ2 SOD1	2.45e-05	3	100	2	30952836
Pubmed	The interaction of angiocidin with tissue transglutaminase.	PSMD4 TGM2	2.45e-05	3	100	2	19931242
Pubmed	CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing.	CCNL2 CCNL1	2.45e-05	3	100	2	17261272
Pubmed	Characterization of cyclin L1 as an immobile component of the splicing factor compartment.	CCNL2 CCNL1	2.45e-05	3	100	2	17494991
Pubmed	Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection.	CCNL2 CCNL1	2.45e-05	3	100	2	18216018
Pubmed	Insulin receptor-related receptor as an extracellular alkali sensor.	INSR INSRR	2.45e-05	3	100	2	21641549
Pubmed	Epigenomic analysis of gastrulation identifies a unique chromatin state for primed pluripotency.	KMT2B TET1	2.45e-05	3	100	2	31844322
Pubmed	DRG2 Regulates G2/M Progression via the Cyclin B1-Cdk1 Complex.	DRG2 CDK1	2.45e-05	3	100	2	27669826
Pubmed	MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders.	MID2 MID1	2.45e-05	3	100	2	11806752
Pubmed	Insulin receptor-related (Irr) is expressed in pre-implantation embryos: a possible relationship to "growth factor Y" and sex determination.	INSR INSRR	2.45e-05	3	100	2	21681845
Pubmed	Evaluation of the possible association of body mass index and four metabolic gene polymorphisms with longevity in an Italian cohort: a role for APOE, eNOS and FTO gene polymorphisms.	FTO NOS3	2.45e-05	3	100	2	31446792
Pubmed	Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure.	INSR NOS3	2.45e-05	3	100	2	19342603
Pubmed	Endothelial nitric oxide synthase-dependent tyrosine nitration of prostacyclin synthase in diabetes in vivo.	NOS3 SOD1	2.45e-05	3	100	2	17065353
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	CCNL2 LRRC8D MELTF TET1 RAI14 KDM4A CAMTA1 FTO HECTD1	2.52e-05	536	100	9	15840001
Pubmed	Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.	PRAMEF33 PRAMEF10 PRAMEF17	2.54e-05	20	100	3	26694250
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	CCNL2 LRRC8D MELTF TET1 RAI14 KDM4A CAMTA1 FTO HECTD1	2.59e-05	538	100	9	10512203
Pubmed	ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.	ZBTB48 ZBTB45 ZBTB21 ZBTB5	3.36e-05	63	100	4	34351428
Pubmed	Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.	PRAMEF33 PRAMEF10 PRAMEF17	3.41e-05	22	100	3	31729367
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	TOR1AIP2 PDLIM7 RNF213 PSMD4 SSH1 AIFM1 RAI14 EIF2AK4 CDK1 NUP93 HARS1 FTO	4.88e-05	1049	100	12	27880917
Pubmed	CDK11(p58) kinase activity is required to protect sister chromatid cohesion at centromeres in mitosis.	CCNL2 CCNL1	4.89e-05	4	100	2	24436071
Pubmed	Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle.	CCNL2 CCNL1	4.89e-05	4	100	2	2217177
Pubmed	MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation.	MID2 MID1	4.89e-05	4	100	2	11685209
Pubmed	MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.	PRAMEF33 PRAMEF10 PRAMEF17	5.07e-05	25	100	3	37451217
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	PDLIM7 RNF213 ANKHD1 FAM120A AIFM1 RAI14 EIF2AK4 CDK1 NUP93	6.10e-05	601	100	9	33658012
Pubmed	Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.	PRAMEF33 PRAMEF10 PRAMEF17	7.17e-05	28	100	3	25089626
Pubmed	Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin.	CCNL2 CCNL1	8.14e-05	5	100	2	11683997
Pubmed	The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2.	INSR INSRR	8.14e-05	5	100	2	19001411
Pubmed	Co-chaperone CHIP associates with mutant Cu/Zn-superoxide dismutase proteins linked to familial amyotrophic lateral sclerosis and promotes their degradation by proteasomes.	PSMD4 SOD1	8.14e-05	5	100	2	15358145
Pubmed	CDK11(p58) protein kinase activity is associated with Bcl-2 down-regulation in pro-apoptosis pathway.	CCNL2 CCNL1	8.14e-05	5	100	2	17516030
Pubmed	Fiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuli.	NOS3 SOD1	8.14e-05	5	100	2	18461174
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TOR1AIP2 CCNL2 USP22 FOXP2 LPCAT4 RNF213 ANKHD1 FAM120A AGO3 ALMS1 UTP25 ZBTB21	8.80e-05	1116	100	12	31753913
Pubmed	Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.	PRAMEF33 PRAMEF10 PRAMEF17	8.85e-05	30	100	3	38786026
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	GALNT2 MID2 INSR RNF213 LRRC8D FAM120A TBCK PLA2G6 CAMKMT RAI14 EIF2AK4 CAMTA1 HECTD1 MTARC1	9.22e-05	1489	100	14	28611215
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZBTB48 FOXP2 PEG3 ZNF786 PDLIM1 ZBTB21 ZBTB5 ZNF616 KDM4A ZNF292	1.14e-04	808	100	10	20412781
Pubmed	The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.	CDK1 NUP93 HECTD1	1.18e-04	33	100	3	26296893
Pubmed	Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding.	MID2 MID1	1.22e-04	6	100	2	16434393
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	DRG2 PEG3 ANKHD1 TGM2 FAM120A AGO3 AIFM1 RAI14 EIF2AK4 NUP93 HARS1 SLIRP SOD1	1.54e-04	1371	100	13	36244648
Pubmed	Cytosolic GDH1 degradation restricts protein synthesis to sustain tumor cell survival following amino acid deprivation.	RNF213 KDM4A	1.70e-04	7	100	2	34269483
Pubmed	Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.	EXT2 FTO	1.70e-04	7	100	2	19008344
Pubmed	Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.	EXT2 FTO	1.70e-04	7	100	2	17928989
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	B3GALNT1 TOR1AIP2 GALNT2 LPCAT4 RNF213 EXT2 LRRC8D TGM2 MELTF PDLIM1 HECTD1 MTARC1	1.74e-04	1201	100	12	35696571
Pubmed	A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus.	INSR NOS3 SOD1	2.11e-04	40	100	3	12732844
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	DRG2 KMT2B ANKHD1 ALMS1 TET1 ZBTB21 RAI14	2.11e-04	418	100	7	34709266
Pubmed	The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia.	CCNL2 PSMD4 CCNL1 PLCG2	2.20e-04	102	100	4	37024974
Pubmed	Altered offspring neurodevelopment in an arginine vasopressin preeclampsia model.	NOS3 SOD1	2.27e-04	8	100	2	33510137
Pubmed	Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation.	NOS3 SOD1	2.27e-04	8	100	2	16000635
Pubmed	Comparative analysis of the signaling capabilities of the insulin receptor-related receptor.	INSR INSRR	2.27e-04	8	100	2	15629149
Pubmed	Human transcription factor protein interaction networks.	KMT2B USP22 FOXP2 MRPL37 PSMD4 ANKHD1 FAM120A AGO3 ALMS1 AIFM1 ZBTB21 RAI14 NUP93	2.31e-04	1429	100	13	35140242
Pubmed	Genetic mapping of 18S ribosomal RNA-related loci to mouse chromosomes 5, 6, 9, 12, 17, 18, 19, and X.	ZP1 NOS3	2.91e-04	9	100	2	8995758
Pubmed	Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors.	CCNL2 CCNL1	2.91e-04	9	100	2	14623875
Pubmed	Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.	PRAMEF10 PEG3 PRAMEF17	3.20e-04	46	100	3	17287250
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	RNF213 AIFM1 MID1 EIF2AK4 CDK1	3.46e-04	208	100	5	33230847
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	TOR1AIP2 DRG2 GALNT2 EXT2 ANKHD1 TBL3 FAM120A AIFM1 RAI14 CDK1 HARS1 HECTD1	3.51e-04	1297	100	12	33545068
Pubmed	DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.	KMT2B TET1	3.63e-04	10	100	2	29276034
Pubmed	An imprinted gene network that controls mammalian somatic growth is down-regulated during postnatal growth deceleration in multiple organs.	PEG3 PLAGL1	3.63e-04	10	100	2	18448610
Pubmed	Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.	ZNF169 FTO	3.63e-04	10	100	2	22344221
Pubmed	Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.	PRAMEF33 PRAMEF10 ZNF101 PRAMEF17 ALMS1 PLA2G6	3.69e-04	326	100	6	17015433
Pubmed	Discovery and refinement of loci associated with lipid levels.	GALNT2 INSR PLA2G6 FTO MTARC1	3.70e-04	211	100	5	24097068
Pubmed	PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome.	PDLIM7 ALMS1 PDLIM1	3.86e-04	49	100	3	31762063
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	PRAMEF33 PRAMEF10 PRAMEF17	4.10e-04	50	100	3	31806660
Pubmed	Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies.	EXT2 FTO	4.43e-04	11	100	2	18597214
Pubmed	Structures of the human mitochondrial ribosome in native states of assembly.	MRPL37 MRPL35 SLIRP	4.60e-04	52	100	3	28892042
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	TOR1AIP2 PSMD4 EXT2 ANKHD1 FAM120A SSH1 CDK1 NUP93 CORO7 HECTD1	5.05e-04	974	100	10	28675297
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	PDLIM7 PSMD4 ANKHD1 TBL3 TGM2 FAM120A AIFM1 RAI14 CDK1 PLCG2 NUP93 CORO7	5.12e-04	1353	100	12	29467282
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	ENPP2 PEG3 KCNQ2 CAMTA1	5.22e-04	128	100	4	30995482
Pubmed	CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome.	CCNL2 CDK1	5.30e-04	12	100	2	24218572
Pubmed	Role of Tet1 in erasure of genomic imprinting.	PEG3 TET1	5.30e-04	12	100	2	24291790
Pubmed	Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons.	PEG3 PLAGL1	5.30e-04	12	100	2	31375626
Pubmed	Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation.	MRPL37 ANKHD1 FAM120A NUP93	5.38e-04	129	100	4	28973437
Pubmed	Defining the membrane proteome of NK cells.	DRG2 GALNT2 LPCAT4 RNF213 EXT2 LRRC8D FAM120A AGO3 CDK1 NUP93 CORO7	5.41e-04	1168	100	11	19946888
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	TOR1AIP2 PDLIM7 AIFM1 CDK1 NUP93	6.03e-04	235	100	5	28378594
Pubmed	Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study.	EXT2 CAMTA1	6.25e-04	13	100	2	18210030
Pubmed	Dysregulation of hypoxia-inducible factor-1α (Hif1α) expression in the Hmox1-deficient placenta.	NOS3 SOD1	6.25e-04	13	100	2	32784053
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	TOR1AIP2 USP22 PSMD4 TBL3 KDM4A EIF2AK4 CDK1 NUP93 SLIRP HECTD1	6.43e-04	1005	100	10	19615732
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	PSMD4 TBL3 TGM2 MELTF UTP25 AIFM1 CDK1 NUP93	6.49e-04	660	100	8	32780723
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	ANKHD1 FAM120A AGO3 ALMS1 ZBTB21 HECTD1	6.58e-04	364	100	6	24778252
Pubmed	Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.	KMT2B AGO3 EIF2AK4	6.67e-04	59	100	3	28813667
Pubmed	The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice.	PEG3 PLAGL1	7.28e-04	14	100	2	21549111
Pubmed	Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1.	USP22 CDK1	8.39e-04	15	100	2	27030811
Pubmed	Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors.	NOS3 SOD1	8.39e-04	15	100	2	19505917
Pubmed	A gene-driven ENU-based approach to generating an allelic series in any gene.	FOXP2 FTO	8.39e-04	15	100	2	15457338
Pubmed	H19 acts as a trans regulator of the imprinted gene network controlling growth in mice.	PEG3 PLAGL1	8.39e-04	15	100	2	19762426
Cytoband	1p36.21	PRAMEF33 PRAMEF10 AADACL3 PRAMEF17	1.14e-05	63	100	4	1p36.21
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	CCNL2 PRAMEF33 PRAMEF10 ZBTB48 AADACL3 PRAMEF17 FAM43B CAMTA1	1.26e-04	681	100	8	chr1p36
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF234 ZNF560 ZBTB48 PEG3 ZNF101 ZNF786 ZNF169 ZNF546 ZBTB45 ZBTB21 ZBTB5 ZNF616 PLAGL1 ZNF853 ZNF763 ZNF292	3.79e-08	718	76	16	28
GeneFamily	Ankyrin repeat domain containing	ESPNL DAPK1 ANKHD1 TRPV4 PLA2G6 RAI14 HECTD1	7.03e-05	242	76	7	403
GeneFamily	Zinc fingers CXXC-type	KMT2B TET1	1.12e-03	12	76	2	136
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB48 ZBTB45 ZBTB21 ZBTB5	2.45e-03	134	76	4	861
GeneFamily	PRAME family	PRAMEF10 PRAMEF17	4.53e-03	24	76	2	686
GeneFamily	Fibronectin type III domain containing	MID2 INSR INSRR MID1	4.62e-03	160	76	4	555
GeneFamily	Ring finger proteins	RNF32 MID2 RNF213 RFPL1 MID1	6.02e-03	275	76	5	58
GeneFamily	Cyclins	CCNL2 CCNL1	6.14e-03	28	76	2	473
Coexpression	GSE17721_CTRL_VS_GARDIQUIMOD_2H_BMDC_DN	TOR1AIP2 TBL3 PDLIM1 NDUFAF7 WNT16 CCNL1 EIF2AK4 NUP93	1.02e-06	200	100	8	M3779
Coexpression	LAKE_ADULT_KIDNEY_C6_PROXIMAL_TUBULE_EPITHELIAL_CELLS_FIBRINOGEN_POS_S3	FOXP2 RNF213 TGM2 FBXL7 CCNL1 SOD1 ZNF292	6.21e-06	181	100	7	M39225
ToppCell	P03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TRIB2 TGM2 ADAMTS18 PLAGL1 TRPV4 NOS3	4.23e-06	188	100	6	5eb107122064f0a99dfd445cc87d3766f7257216
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TRIB2 TGM2 ADAMTS18 PLAGL1 TRPV4 NOS3	4.63e-06	191	100	6	fcdf3a747038e346a467eae8b7c293592658b53f
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_BHLHE22\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRHDE PLCXD2 DAPK1 MID1 PLAGL1 CAMTA1	4.77e-06	192	100	6	25460ca9ebd3d49f666394cf99ab77a5e8f77250
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ENPP2 INSR FBXL7 PDLIM1 PLCG2 NOS3	5.06e-06	194	100	6	a429d22c8c9d0fd3bfa9f877a6364cecad68db30
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	INSR TGM2 FBXL7 SSH1 PDLIM1 NOS3	5.22e-06	195	100	6	818bc18c5834238e5f733cac6fe928ed0788f57d
ToppCell	LPS_only-Endothelial-Endothelial-Vein\|LPS_only / Treatment groups by lineage, cell group, cell type	TGM2 FBXL7 PDLIM1 MID1 RAI14 NOS3	6.03e-06	200	100	6	b036f5e22c95a3b14391785b6e91aa183b9bc9a8
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TRIB2 ENPP2 RNF213 TGM2 PDLIM1 RAI14	6.03e-06	200	100	6	2d07237022b409c4fac6fcf99b68c8affb3007cd
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-dn_T\|Int-URO / Disease, condition lineage and cell class	MRPL37 ZNF786 SLC9B1 ZBTB45 TBCK HARS1	6.03e-06	200	100	6	020439d9e70fff7246650ab0e9105236688c3ec3
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_A2\|343B / Donor, Lineage, Cell class and subclass (all cells)	B3GALNT1 GALNT2 ZNF786 ZBTB45 TET1	1.26e-05	133	100	5	8ff1cf0ea1fc33fe8384c0e65c1ee1853b25a2ae
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	B3GALNT1 ZNF560 PEG3 SLC9B1 FBXL7	3.45e-05	164	100	5	d167c7a987b9b35d1e7725c803df4f9cd5380e47
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRHDE TRIB2 FOXP2 PLCXD2 PDLIM1	3.65e-05	166	100	5	01544c851588f1cde05d6700c3d1167f70a0fbd5
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TRHDE TRIB2 FOXP2 PLCXD2 PDLIM1	3.65e-05	166	100	5	c22a97353f7eb084f768c13d7767a80b30f05043
ToppCell	Int-URO-Lymphocyte-T_NK-dnT\|Int-URO / Disease, Lineage and Cell Type	ZNF786 SLC9B1 ZBTB45 TBCK HARS1	4.32e-05	172	100	5	e70299573da1679d6d286c3a43699cbff76e207d
ToppCell	CV-Mild-7\|Mild / Virus stimulation, Condition and Cluster	CCNL2 DAPK1 ZBTB5 ZNF616 ZNF763	4.45e-05	173	100	5	c9bbca9313a0fdf146c8c995624b94b937e818d8
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte-Chondrocyte_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ENPP2 PEG3 TGM2 TRPV4 CAMKMT	4.70e-05	175	100	5	a5db428b078938627e61b7e944c1e0c1d61ac2da
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ENPP2 PEG3 TGM2 TRPV4 CAMKMT	4.70e-05	175	100	5	8b498eea1ec1c1f27b171025c3d08adf3687bafc
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	RNF213 ZNF169 MELTF AGO3 TBCK	4.96e-05	177	100	5	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-Tuft\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRHDE FAM43B ADAMTS18 PLCG2 MTARC1	5.09e-05	178	100	5	f17c3b7bb562ac24c6a03fe3c9ba94c2b434c141
ToppCell	5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGM2 SSH1 RAI14 ADGRA1 NOS3	5.23e-05	179	100	5	9fd9b136ecbcbd4e4f0d5875ede98d8d48608afb
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_A2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	B3GALNT1 GALNT2 ZNF786 ZBTB45 TET1	5.37e-05	180	100	5	62511d76d24b836839c3dcc2bf30485ffe9401e2
ToppCell	wk_15-18-Mesenchymal-Chondrocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FOXP2 ENPP2 PEG3 PLAGL1 TRPV4	5.51e-05	181	100	5	8950844b3e65c7028d80da5787ae2ce509c3d52d
ToppCell	COVID-19-kidney-CD-IC-B\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TRHDE INSRR ADAMTS18 ADGRA1 PLCG2	5.66e-05	182	100	5	ee6a8c356bbbdae55e4ea858337e079491f9f4aa
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_A2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	B3GALNT1 GALNT2 ZNF786 ZBTB45 TET1	5.66e-05	182	100	5	03992d0ae519795239e4f2cc8e63f33c4482de6a
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ENPP2 INSR FBXL7 PDLIM1 NOS3	5.80e-05	183	100	5	dc19857b66dcadbf7c87de91f7b1f4e8ef2857ed
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ENPP2 INSR FBXL7 PDLIM1 NOS3	5.80e-05	183	100	5	4759560e5b4f4e5a00e5f933e3451a27c7c4aefe
ToppCell	COVID-19-Endothelial_cells-Arterial_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	ENPP2 TGM2 FBXL7 PDLIM1 NOS3	5.96e-05	184	100	5	0f19494789f38ab1a420545e15e748ca7eb345c3
ToppCell	Substantia_nigra-Neuronal-Inhibitory\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	PLCXD2 PEG3 FAM43B KCNQ2 CAMTA1	6.27e-05	186	100	5	9d3efe2a4feea2bc205a7e45b9b9f9ed9b3609ce
ToppCell	COVID-19-kidney-VWF+PLVAP+VCAM1+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	INSR FBXL7 MID1 RAI14 NOS3	6.76e-05	189	100	5	c121817ddad164e9cfe382c43d0cbc9215508d02
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INSR TGM2 PDLIM1 TRPV4 NOS3	6.76e-05	189	100	5	d9c2adbbe3e40eb8d57200b6411533e6685ea0d2
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRHDE OXR1 FOXP2 DAPK1 MID1	6.76e-05	189	100	5	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Endothelial-endothelial_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INSR TGM2 PDLIM1 TRPV4 NOS3	6.76e-05	189	100	5	476226787c8ea0c9834a6f4c99ac7091cc20a455
ToppCell	RA-10._Endothelium_II\|World / Chamber and Cluster_Paper	OXR1 DAPK1 TGM2 RAI14 NOS3	6.76e-05	189	100	5	75c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Endothelial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INSR TGM2 PDLIM1 TRPV4 NOS3	6.76e-05	189	100	5	3fe69bad6427e41b8d2dae450828cc21e9c3b3ad
ToppCell	NS-moderate-d_16-33-Epithelial-FOXN4+\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	POC1A MELTF ALMS1 ZBTB21 CDK1	6.93e-05	190	100	5	250ca4a605c1cccd77d23383e4fe6f91cf3609ba
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TRIB2 TGM2 ADAMTS18 PLAGL1 NOS3	7.11e-05	191	100	5	0e8a73f01e3ec95d242c09231bcf3790324d0a67
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	RNF213 ZNF169 TBCK TMEM68 ZNF292	7.11e-05	191	100	5	9454f642c3621370fa23640b631301346b300950
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TRIB2 TGM2 ADAMTS18 PLAGL1 NOS3	7.11e-05	191	100	5	54bbccc554f43ba2ebdf9ea191b94c8f16081b53
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	ENPP2 TBCK ADAMTS18 PLAGL1 ZNF292	7.28e-05	192	100	5	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	343B-Lymphocytic-ILC-ILC-1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	USP22 TBL3 TGM2 TET1 ZBTB21	7.28e-05	192	100	5	445985fe1bcd33e4f0a1704b27988fbfc9334538
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TRIB2 PEG3 TGM2 PLAGL1 NOS3	7.28e-05	192	100	5	cd4c9b9ab17a779c154264f7459020f51e528ba5
ToppCell	3'-Distal_airway-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ENPP2 TGM2 SSH1 PDLIM1 NOS3	7.46e-05	193	100	5	1e6e2d786511cc40241197368f5df20c20b882f3
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	TBCK ADAMTS18 PLAGL1 PLCG2 ZNF292	7.46e-05	193	100	5	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	moderate-Epithelial-FOXN4+\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	POC1A MELTF ALMS1 ZBTB21 CDK1	7.65e-05	194	100	5	5dffa578149104dda33774361e9e77b227b5f1ce
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TRHDE OXR1 FOXP2 RNF213 DAPK1	7.65e-05	194	100	5	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_B-Plasma_cell-B_c06-MKI67\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	POC1A MRPL37 MRPL35 PDLIM1 CDK1	7.65e-05	194	100	5	5771a28a61f4d9b5479891f3224909ab003cb241
ToppCell	moderate-Epithelial-FOXN4+\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	POC1A MELTF ALMS1 ZBTB21 CDK1	7.65e-05	194	100	5	dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	INSR TGM2 PDLIM1 RAI14 NOS3	7.83e-05	195	100	5	4658fb197657d7692ee344ae76b11b0210c418ba
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TGM2 FBXL7 SSH1 PDLIM1 NOS3	8.03e-05	196	100	5	7cbb19108b4553ef60ef5c230a29de1662c02efe
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TGM2 FBXL7 SSH1 PDLIM1 NOS3	8.03e-05	196	100	5	4cd1e6b7a791e11a40b19f971b7011bd11fe6273
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Macroglial-Glia_progenitor_cell\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	TOR1AIP2 MRPL35 UTP25 ZBTB5 ADAMTS18	8.03e-05	196	100	5	7be50b9156394dea44d7b8b476d4dd516abfafae
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRHDE OXR1 FOXP2 DAPK1 CAMKMT	8.03e-05	196	100	5	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ENPP2 INSR FBXL7 PDLIM1 NOS3	8.03e-05	196	100	5	e224338490691d92c1f70b57112fabdcc92b06a9
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ENPP2 INSR FBXL7 PDLIM1 NOS3	8.22e-05	197	100	5	c10dd1aaec01fb662eac83dfde90e3e426665d65
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ENPP2 PDLIM1 ADAMTS18 RAI14 NOS3	8.22e-05	197	100	5	78bc83cd5546c7dd128e6791acda97f55089bc1c
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ENPP2 INSR FBXL7 PDLIM1 NOS3	8.22e-05	197	100	5	2844dbcd0a673ed81c99920aa45858651a00736d
ToppCell	ASK452-Endothelial-Endothelium\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	ENPP2 TGM2 SSH1 PDLIM1 NOS3	8.42e-05	198	100	5	e282769f5fa1765bcce79a0ed9d761bf2e14b012
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ENPP2 TGM2 SSH1 PDLIM1 NOS3	8.62e-05	199	100	5	6e3a226ebba023e3e909d7a7188137da4f1fd7fc
ToppCell	ASK452-Endothelial\|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq	ENPP2 TGM2 SSH1 PDLIM1 NOS3	8.62e-05	199	100	5	0bc97a9a78aaafd1554ae6a61356ed9ea4983fa5
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Vein\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	TGM2 FBXL7 PDLIM1 RAI14 NOS3	8.62e-05	199	100	5	cfb624c7728046fc7f3ef071f57e4d7b013f3fef
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Vein\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TGM2 FBXL7 PDLIM1 RAI14 NOS3	8.83e-05	200	100	5	b3f93b71589251197cde96b7bc6d065c106f61cd
ToppCell	(09)_Ionocytes-(3)_72hpi\|(09)_Ionocytes / shred by cell type and Timepoint	TRIB2 TET1 EIF2AK4 CAMTA1	1.11e-04	110	100	4	fce7d5a0617fc664b657f5bb9abb290e7cc234cb
Disease	glucose metabolism disease (implicated_via_orthology)	TRIB2 INSR INSRR	9.68e-05	28	94	3	DOID:4194 (implicated_via_orthology)
Disease	Opitz GBBB syndrome (implicated_via_orthology)	MID2 MID1	1.49e-04	6	94	2	DOID:0080697 (implicated_via_orthology)
Disease	retinopathy of prematurity (is_implicated_in)	NOS3 SOD1	2.09e-04	7	94	2	DOID:13025 (is_implicated_in)
Disease	triglyceride measurement, alcohol drinking	GALNT2 INSR PLA2G6 MTARC1	2.88e-04	99	94	4	EFO_0004329, EFO_0004530
Disease	non-alcoholic fatty liver disease	DRG2 INSR ZNF101 FTO MTARC1	2.98e-04	182	94	5	EFO_0003095
Disease	triglyceride measurement, alcohol consumption measurement	GALNT2 INSR PLA2G6 MTARC1	3.11e-04	101	94	4	EFO_0004530, EFO_0007878
Disease	opioid use disorder	FOXP2 CAMKMT KDM4A FTO	3.11e-04	101	94	4	EFO_0010702
Disease	alcohol dependence (implicated_via_orthology)	INSR INSRR	3.56e-04	9	94	2	DOID:0050741 (implicated_via_orthology)
Disease	Streptozotocin Diabetes	INSR AIFM1 NOS3 SOD1	4.02e-04	108	94	4	C0038433
Disease	Diabetes Mellitus, Experimental	INSR AIFM1 NOS3 SOD1	4.02e-04	108	94	4	C0011853
Disease	Alloxan Diabetes	INSR AIFM1 NOS3 SOD1	4.02e-04	108	94	4	C0002152
Disease	sleep disorder (implicated_via_orthology)	INSR INSRR	5.42e-04	11	94	2	DOID:535 (implicated_via_orthology)
Disease	smoking cessation	ENPP2 ALMS1 CCNL1 KCNQ2 CAMKMT CAMTA1	6.16e-04	325	94	6	EFO_0004319
Disease	substance-related disorder	FOXP2 CAMKMT FTO	6.18e-04	52	94	3	MONDO_0002494
Disease	very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio	GALNT2 INSR SLC9B1 NUP93 MTARC1	7.35e-04	222	94	5	EFO_0008317, EFO_0020943
Disease	diabetic neuropathy (implicated_via_orthology)	INSR INSRR	8.91e-04	14	94	2	DOID:9743 (implicated_via_orthology)
Disease	free cholesterol to total lipids in medium HDL percentage	GALNT2 NUP93 MTARC1	9.39e-04	60	94	3	EFO_0022282
Disease	very low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	GALNT2 INSR SLC9B1 NUP93 MTARC1	1.02e-03	239	94	5	EFO_0008317, EFO_0020945
Disease	N-acetylmethionine measurement	POC1A ALMS1	1.03e-03	15	94	2	EFO_0021427
Disease	mean arterial pressure	INSR RNF213 DAPK1 UTP25 EIF2AK4 FTO NOS3	1.09e-03	499	94	7	EFO_0006340
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	TRIB2 GALNT2 TET1 PLA2G6 CAMTA1 FTO	1.11e-03	364	94	6	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	diabetic retinopathy (implicated_via_orthology)	INSR NOS3	1.17e-03	16	94	2	DOID:8947 (implicated_via_orthology)
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	KMT2B ZNF292	1.32e-03	17	94	2	DOID:0060307 (is_implicated_in)
Disease	essential hypertension (is_implicated_in)	FTO NOS3	1.49e-03	18	94	2	DOID:10825 (is_implicated_in)
Disease	phospholipids in large HDL measurement	GALNT2 NUP93 MTARC1	1.66e-03	73	94	3	EFO_0022190
Disease	polycystic kidney disease (biomarker_via_orthology)	NOS3 SOD1	1.66e-03	19	94	2	DOID:0080322 (biomarker_via_orthology)
Disease	total lipids in large HDL	GALNT2 NUP93 MTARC1	1.72e-03	74	94	3	EFO_0022189
Disease	alcohol consumption measurement, high density lipoprotein cholesterol measurement	GALNT2 INSR PLA2G6 MTARC1	1.82e-03	162	94	4	EFO_0004612, EFO_0007878
Disease	unipolar depression, bipolar disorder, schizophrenia	FOXP2 FTO	1.84e-03	20	94	2	EFO_0003761, MONDO_0004985, MONDO_0005090
Disease	Fetal Growth Retardation	NOS3 SOD1	1.84e-03	20	94	2	C0015934
Disease	alcohol drinking, high density lipoprotein cholesterol measurement	GALNT2 INSR PLA2G6 MTARC1	2.08e-03	168	94	4	EFO_0004329, EFO_0004612
Disease	free cholesterol in large HDL measurement	GALNT2 NUP93 MTARC1	2.08e-03	79	94	3	EFO_0022157
Disease	cholesterol in large HDL measurement	GALNT2 NUP93 MTARC1	2.15e-03	80	94	3	EFO_0021900
Disease	neuroimaging measurement	KMT2B FOXP2 HAGHL ENPP2 RNASE12 FBXL7 WNT16 ADAMTS18 CDK1 CAMTA1	2.16e-03	1069	94	10	EFO_0004346
Disease	complement factor H-like 1 protein measurement	FAM43B KCNQ2	2.23e-03	22	94	2	EFO_0600092
Disease	sciatic neuropathy (implicated_via_orthology)	FTO SOD1	2.43e-03	23	94	2	DOID:11446 (implicated_via_orthology)
Disease	congenital diaphragmatic hernia (biomarker_via_orthology)	NOS3 SOD1	2.65e-03	24	94	2	DOID:3827 (biomarker_via_orthology)
Disease	alcohol use disorder measurement, alcohol dependence	CAMKMT FTO	2.65e-03	24	94	2	EFO_0009458, MONDO_0007079
Disease	3-hydroxybutyrate measurement	GALNT2 MTARC1	2.87e-03	25	94	2	EFO_0010982
Disease	childhood aggressive behaviour measurement	KDM4A PLCG2 HECTD1	2.92e-03	89	94	3	EFO_0007663
Disease	breast cancer (is_marker_for)	KMT2B INSR KDM4A CDK1	2.94e-03	185	94	4	DOID:1612 (is_marker_for)
Disease	hypertension	INSR RNF213 UTP25 KDM4A NOS3	3.05e-03	307	94	5	EFO_0000537
Disease	diabetes mellitus (implicated_via_orthology)	INSR INSRR	3.10e-03	26	94	2	DOID:9351 (implicated_via_orthology)
Disease	Endogenous Hyperinsulinism	INSR NOS3	3.10e-03	26	94	2	C1257963
Disease	Exogenous Hyperinsulinism	INSR NOS3	3.10e-03	26	94	2	C1257964
Disease	Compensatory Hyperinsulinemia	INSR NOS3	3.10e-03	26	94	2	C1257965

Protein segments in the cluster

Peptide	Gene	Start	Entry
IHYRRGLVHLCCSKV	PRAMEF33	171	A0A0G2JMD5
ERHIAVHKRLVLAFA	TRHDE	31	Q9UKU6
LVEACRKRHLHAVEG	CCDC185	401	Q8N715
DKDGHIALHLAVRRC	DAPK1	541	P53355
ARSRGHVKLAECLEH	CAMTA1	1151	Q9Y6Y1
HVCETIIRIFKRHGA	EIF2AK4	1066	Q9P2K8
CFYDIKLGRRRVEHH	AIFM1	441	O95831
VTLGLFVLIHHCAKR	ADGRA1	296	Q86SQ6
HIIIESHEKGCFRTL	ALMS1	2576	Q8TCU4
IVVQKRHHTRLFCAD	AGO3	706	Q9H9G7
AVGHPVKLRVLHCIF	AADACL3	36	Q5VUY0
RRVLKELGFCVHVKH	CCNL1	186	Q9UK58
KRHDHAILLTGFDIC	ADAMTS18	381	Q8TE60
RCHAVHVALVLFELK	NUP93	486	Q8N1F7
AFHLAAAKGHVECLR	RAI14	56	Q9P0K7
HGEELRFGAIHVRCL	HAGHL	91	Q6PII5
LERHFKGHRDAVTCV	POC1A	11	Q8NBT0
KLRHLLCFEVFEHLG	ESPNL	876	Q6ZVH7
IHYRRGLVHLCCNKV	PRAMEF17	171	Q5VTA0
VHKCRVHGLEIEGRD	MTARC1	146	Q5VT66
VHELHLSRLQRVKFC	LPCAT4	26	Q643R3
TLHKHGCLFRDLVRI	FTO	71	Q9C0B1
QARHKAVVLRCHAVL	FAM43B	166	Q6ZT52
CHAVLLARAHKARAL	FAM43B	176	Q6ZT52
IIPCSRVGHVFRKQH	GALNT2	351	Q10471
HLDVCQLRRVIAAHG	B3GALNT1	296	O75752
DKRRVAHLGCHSDLV	CORO7	66	P57737
SREHVDRHGCIVKIV	KCNQ2	676	O43526
AVRHNLSLHKCFVRV	FOXP2	551	O15409
KHRIGTKRHRVCLEI	KDM4A	391	O75164
PRIKHVCRHAAVALG	KMT2B	866	Q9UMN6
AAHCRKKVFRVRLGH	KLK5	106	Q9Y337
HCIRLALIRFHVKVA	FAM120A	146	Q9NZB2
LHLCVSRKHFALERG	INSR	896	P06213
KHCRINRDGRHFVLG	PLCG2	691	P16885
IFHHRCRLLEGVKQA	MRPL37	106	Q9BZE1
VCHQCHKVIRGRYLV	PDLIM7	281	Q9NR12
AEHRKIHARGYLVEC	PEG3	521	Q9GZU2
LAAEVHRVLCLERGH	NOS3	1096	P29474
QRHRLHKFLCLRVGK	OXR1	551	Q8N573
VIKGRDSCHRIHVNL	IL1RL2	96	Q9HB29
CVLTFIRDSGHLVHK	HECTD1	146	Q9ULT8
RVRAHLEAAGHVCVL	GLT1D1	21	Q96MS3
LRFVKRHCKRCVIEH	FBXL7	471	Q9UJT9
RRVLKELGFCVHVKH	CCNL2	181	Q96S94
AFKCHHVVRLLGVVS	INSRR	1036	P14616
ICFHKHVRIERLVIQ	HSPB11	51	Q9Y547
FCTGIRVAHLALKHR	PSMD4	86	P55036
HVFIHERPRKINGIC	RNASE12	66	Q5GAN4
VFDVIIRCFKRHGAE	HARS1	76	P12081
LKLHRCVNVIFVGDH	ENPP2	346	Q13822
RDHLRCLHVKFTDVA	LRRC8D	536	Q7L1W4
GIVGVFVKLRDRHRH	PDLIM1	266	O00151
EKLCGHHFVRALVRV	INSL3	31	P51460
KNGEEIRHVYCLHVI	UTP25	301	Q68CQ4
VCRESVHRKGRIHLT	RFPL1	196	O75677
HKEKVVCIAAGLRHA	SERGEF	151	Q9UGK8
AREGRETLKCLSHHV	TOR1AIP2	301	Q8NFQ8
VRRHLVVHTGCKDFL	PLAGL1	171	Q9UM63
CHLARVPAHAVVVRA	MELTF	271	P08582
FRGFCDHKLHDVLIA	NDUFAF7	311	Q7L592
RVIHDGARLFRIKCV	RNF32	176	Q9H0A6
TVKAVIDRFLRLHCG	MRPL35	106	Q9NZE8
AVELGIRECFHHSRI	PLA2G6	126	O60733
AIILRKGASVEHVCH	DRG2	306	P55039
HCIIGRTLVVHEKAD	SOD1	111	P00441
ALQVLHKACEVARRH	SSH1	181	Q8WYL5
EKVLCLVRQRTGHHC	TET1	1496	Q8NFU7
KFCELLIHRGAHIDV	ANKHD1	1306	Q8IWZ3
IVFCHSRRVLHRDLK	CDK1	116	P06493
KHLDDCLRHVSVRRF	CAMKMT	51	Q7Z624
HHTADLCREKLVVRR	TGM2	21	P21980
HRVKCRVHPNFRLIV	RNF213	3136	Q63HN8
RVHVRRHKGVRKFEC	ZBTB48	566	P10074
FLIAALDVLHRHCKG	USP22	266	Q9UPT9
CLKIFRSTAGLHRHV	ZBTB21	551	Q9ULJ3
CVIVVGNRHFKAHRS	ZBTB5	26	O15062
LAVHRRIHTVEKPCK	ZNF616	396	Q08AN1
CGKVFSHRALLERHL	ZBTB45	491	Q96K62
IHKGRTCRVVADHFV	TMEM68	146	Q96MH6
CHVLEKDGRFHLRVF	ZP1	101	P60852
THHKCLVLRIQEAFG	PLCXD2	171	Q0VAA5
RHCHEAQAVLGVLLR	TBL3	726	Q12788
FRAVHLHSGEELVCK	TRIB2	76	Q92519
ALCKLVGRHRDHQVA	MID1	196	O15344
EGVLSVRKRCHKHQV	EXT2	291	Q93063
GKAFCRVGDLRVHHT	ZNF546	251	Q86UE3
LCDKEFLGHRIVRHA	ZNF292	546	O60281
IHYRRGLVHLCCSKV	PRAMEF10	171	O60809
THVVRHVERCECKFI	WNT16	331	Q9UBV4
ALRHLKVVCFRLAVG	SLC9B1	176	Q4ZJI4
RGKHERLVVVAEHCE	TBCK	61	Q8TEA7
KEHFAQFGHVRRCIL	SLIRP	36	Q9GZT3
RADLKIHCRIHTGEK	ZNF234	496	Q14588
RGFTHQCKLREHLRV	ZNF786	516	Q8N393
DCGERFRHKVQIRRH	ZNF853	601	P0CG23
VCGKVFLRHSFLDRH	ZNF101	106	Q8IZC7
ALCKLVGRHRDHQVA	MID2	216	Q9UJV3
GKAVHCLRLYLIHER	ZNF763	206	Q0D2J5
ALHIAIERRCKHYVE	TRPV4	241	Q9HBA0
ECGHSFRQKVTLIRH	ZNF169	406	Q14929
SAGLIEHIRCHAREK	ZNF560	416	Q96MR9