Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone binding

TSPYL2 TSPY4 TSPY3 SMARCA2 TSPY10 TSPY2 TSPY9 CHD8 CHD7 TSPY8 TSPY1 TAF1L

3.41e-112656312GO:0042393
GeneOntologyMolecularFunctionchromatin binding

NSD2 TSPYL2 TSPY4 TSPY3 SMARCA2 TSPY10 TSPY2 TSPY9 CHD8 CHD7 TSPY8 TSPY1 TAF1L HES5 DDX5

6.79e-097396315GO:0003682
GeneOntologyMolecularFunctionhelicase activity

SMARCA2 CHD8 CHD7 SNRNP200 DDX27 DDX5

1.04e-05158636GO:0004386
GeneOntologyMolecularFunctionnuclear receptor binding

PRAMEF5 PRPF6 PRAMEF26 TAF1L DDX5 PRAMEF6

2.72e-05187636GO:0016922
GeneOntologyMolecularFunctionp53 binding

NOP53 CHD8 TAF1L PTTG1IP

1.02e-0477634GO:0002039
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

TUT7 SMARCA2 CHD8 CHD7 TOP6BL POLD3 SNRNP200 DDX27 DDX5

1.80e-04645639GO:0140640
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

SMARCA2 CHD8 CHD7

2.15e-0437633GO:0140658
GeneOntologyMolecularFunctionATP-dependent activity

SMARCA2 CHD8 CHD7 ATP8B1 TOP6BL SNRNP200 DDX27 DDX5

6.67e-04614638GO:0140657
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

SMARCA2 CHD8 CHD7 TOP6BL

6.96e-04127634GO:0008094
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

PRAMEF5 PRAMEF26 PRAMEF6

6.99e-0455633GO:0042974
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

SMARCA2 CHD8 CHD7 TOP6BL POLD3

1.42e-03262635GO:0140097
GeneOntologyMolecularFunctionRNA helicase activity

SNRNP200 DDX27 DDX5

1.92e-0378633GO:0003724
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

PRAMEF5 PRPF6 PRAMEF26 TAF1L DDX5 PRAMEF6

1.99e-03417636GO:0061629
GeneOntologyMolecularFunctionATP-dependent activity, acting on RNA

SNRNP200 DDX27 DDX5

2.07e-0380633GO:0008186
GeneOntologyMolecularFunctionubiquitin-like ligase-substrate adaptor activity

PRAMEF5 PRAMEF26 PRAMEF6

2.22e-0382633GO:1990756
GeneOntologyMolecularFunctionpromoter-specific chromatin binding

CHD7 TAF1L DDX5

2.30e-0383633GO:1990841
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

PRAMEF5 PRPF6 PRAMEF26 TAF1L ZNF653 DDX5 PRAMEF6

2.32e-03582637GO:0140297
GeneOntologyMolecularFunctionATP hydrolysis activity

CHD8 CHD7 ATP8B1 SNRNP200 DDX27 DDX5

2.63e-03441636GO:0016887
GeneOntologyMolecularFunctionenzyme-substrate adaptor activity

PRAMEF5 PRAMEF26 PRAMEF6

3.37e-0395633GO:0140767
GeneOntologyMolecularFunctionactin monomer binding

LMOD3 PRKCE

3.77e-0329632GO:0003785
GeneOntologyMolecularFunctionribonucleoprotein complex binding

SECISBP2L PRPF6 ZNF593 DDX5

4.08e-03206634GO:0043021
GeneOntologyBiologicalProcessgonadal mesoderm development

TSPY4 TSPY3 TSPY10 TSPY2 TSPY9 TSPY8 TSPY1

8.86e-179667GO:0007506
GeneOntologyBiologicalProcessnucleosome assembly

TSPYL2 TSPY4 TSPY3 SMARCA2 TSPY10 TSPY2 TSPY9 TSPY8 TSPY1

1.83e-10122669GO:0006334
GeneOntologyBiologicalProcessnucleosome organization

TSPYL2 TSPY4 TSPY3 SMARCA2 TSPY10 TSPY2 TSPY9 TSPY8 TSPY1

7.14e-10142669GO:0034728
GeneOntologyBiologicalProcessprotein-DNA complex assembly

TSPYL2 TSPY4 TSPY3 SMARCA2 TSPY10 TSPY2 TSPY9 TSPY8 TSPY1 TAF1L

6.40e-092496610GO:0065004
GeneOntologyBiologicalProcesschromatin remodeling

BRPF3 NSD2 TSPYL2 TSPY4 TSPY3 SMARCA2 TSPY10 TSPY2 TSPY9 CHD8 CHD7 TSPY8 TSPY1 TAF1L

7.23e-087416614GO:0006338
GeneOntologyBiologicalProcessmesoderm development

TSPY4 TSPY3 TSPY10 TSPY2 TSPY9 TSPY8 TSPY1

6.92e-07157667GO:0007498
GeneOntologyBiologicalProcesschromatin organization

BRPF3 NSD2 TSPYL2 TSPY4 TSPY3 SMARCA2 TSPY10 TSPY2 TSPY9 CHD8 CHD7 TSPY8 TSPY1 TAF1L

7.25e-078966614GO:0006325
GeneOntologyBiologicalProcessprotein-DNA complex organization

BRPF3 NSD2 TSPYL2 TSPY4 TSPY3 SMARCA2 TSPY10 TSPY2 TSPY9 CHD8 CHD7 TSPY8 TSPY1 TAF1L

2.62e-069996614GO:0071824
GeneOntologyBiologicalProcesssex differentiation

TSPY4 TSPY3 TSPY10 TSPY2 TSPY9 CHD7 TSPY8 TSPY1

1.61e-05352668GO:0007548
GeneOntologyBiologicalProcessmesenchyme development

TSPY4 TSPY3 TSPY10 TSPY2 TSPY9 TSPY8 TSPY1 DDX5

2.40e-05372668GO:0060485
GeneOntologyBiologicalProcessreproductive structure development

TSPY4 TSPY3 TSPY10 TSPY2 TSPY9 CHD7 TSPY8 TSPY1

2.95e-05383668GO:0048608
GeneOntologyBiologicalProcessreproductive system development

TSPY4 TSPY3 TSPY10 TSPY2 TSPY9 CHD7 TSPY8 TSPY1

3.23e-05388668GO:0061458
GeneOntologyBiologicalProcessgonad development

TSPY4 TSPY3 TSPY10 TSPY2 TSPY9 TSPY8 TSPY1

4.04e-05292667GO:0008406
GeneOntologyBiologicalProcessdevelopment of primary sexual characteristics

TSPY4 TSPY3 TSPY10 TSPY2 TSPY9 TSPY8 TSPY1

4.50e-05297667GO:0045137
GeneOntologyBiologicalProcessnegative regulation of DNA-templated transcription

PRAMEF5 NSD2 NOP53 ZBTB21 SMARCA2 ZBTB5 CHD8 ATP8B1 MAGEB17 PRAMEF26 HES5 ZNF653 DDX5 PRAMEF6

1.12e-0413996614GO:0045892
GeneOntologyBiologicalProcessnegative regulation of RNA biosynthetic process

PRAMEF5 NSD2 NOP53 ZBTB21 SMARCA2 ZBTB5 CHD8 ATP8B1 MAGEB17 PRAMEF26 HES5 ZNF653 DDX5 PRAMEF6

1.25e-0414136614GO:1902679
GeneOntologyBiologicalProcessgamete generation

PRAMEF5 TUT7 TSPY4 TSPY3 SMARCA2 TSPY10 TSPY2 TSPY9 TSPY8 TSPY1 PRAMEF6

2.61e-049826611GO:0007276
GeneOntologyBiologicalProcessdevelopmental process involved in reproduction

PRAMEF5 TUT7 TSPY4 TSPY3 SMARCA2 TSPY10 TSPY2 TSPY9 CHD7 TSPY8 TSPY1 PRAMEF6

4.89e-0412356612GO:0003006
GeneOntologyBiologicalProcessskeletal myofibril assembly

LMOD3 PLEC

5.44e-0411662GO:0014866
GeneOntologyCellularComponentchromatin

BRPF3 PRAMEF5 NSD2 NOP53 TSPYL2 TSPY4 TSPY3 SMARCA2 TSPY10 ZBTB5 TSPY2 TSPY9 CHD8 CHD7 TSPY8 TSPY1 PRAMEF26 TAF1L HES5 PRAMEF6

1.53e-0814806620GO:0000785
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

PRAMEF5 PRAMEF26 PRAMEF6

4.41e-0447663GO:0031462
DomainNAP

TSPYL2 TSPY4 TSPY10 TSPY2 TSPY8

1.73e-0917605PF00956
DomainNAP_family

TSPYL2 TSPY4 TSPY10 TSPY2 TSPY8

1.73e-0917605IPR002164
DomainBRK

SMARCA2 CHD8 CHD7

6.26e-076603SM00592
DomainBRK_domain

SMARCA2 CHD8 CHD7

6.26e-076603IPR006576
DomainBRK

SMARCA2 CHD8 CHD7

6.26e-076603PF07533
DomainHelicase_C

SMARCA2 CHD8 CHD7 SNRNP200 DDX27 DDX5

1.20e-06107606PF00271
DomainHELICc

SMARCA2 CHD8 CHD7 SNRNP200 DDX27 DDX5

1.20e-06107606SM00490
DomainHelicase_C

SMARCA2 CHD8 CHD7 SNRNP200 DDX27 DDX5

1.26e-06108606IPR001650
DomainHELICASE_CTER

SMARCA2 CHD8 CHD7 SNRNP200 DDX27 DDX5

1.33e-06109606PS51194
DomainHELICASE_ATP_BIND_1

SMARCA2 CHD8 CHD7 SNRNP200 DDX27 DDX5

1.33e-06109606PS51192
DomainDEXDc

SMARCA2 CHD8 CHD7 SNRNP200 DDX27 DDX5

1.33e-06109606SM00487
DomainHelicase_ATP-bd

SMARCA2 CHD8 CHD7 SNRNP200 DDX27 DDX5

1.41e-06110606IPR014001
DomainBromodomain_CS

BRPF3 SMARCA2 TAF1L

7.77e-0526603IPR018359
DomainSNF2_N

SMARCA2 CHD8 CHD7

1.46e-0432603IPR000330
DomainSNF2_N

SMARCA2 CHD8 CHD7

1.46e-0432603PF00176
DomainBROMODOMAIN_1

BRPF3 SMARCA2 TAF1L

2.27e-0437603PS00633
DomainBromodomain

BRPF3 SMARCA2 TAF1L

2.45e-0438603PF00439
DomainBROMODOMAIN_2

BRPF3 SMARCA2 TAF1L

3.08e-0441603PS50014
DomainBROMO

BRPF3 SMARCA2 TAF1L

3.31e-0442603SM00297
DomainBromodomain

BRPF3 SMARCA2 TAF1L

3.31e-0442603IPR001487
Domain-

BRPF3 SMARCA2 TAF1L

3.31e-04426031.20.920.10
Domain-

FLII LMOD3 OPTC PRAMEF5 LRRTM4 PRAMEF6

5.64e-043216063.80.10.10
DomainL_dom-like

FLII LMOD3 OPTC PRAMEF5 LRRTM4 PRAMEF6

6.32e-04328606IPR032675
DomainDEAD/DEAH_box_helicase_dom

SNRNP200 DDX27 DDX5

1.67e-0373603IPR011545
DomainDEAD

SNRNP200 DDX27 DDX5

1.67e-0373603PF00270
DomainPRAME_family

PRAMEF5 PRAMEF6

1.68e-0319602IPR026271
DomainPWWP

BRPF3 NSD2

1.86e-0320602SM00293
DomainPWWP

BRPF3 NSD2

2.46e-0323602PF00855
DomainPWWP_dom

BRPF3 NSD2

2.46e-0323602IPR000313
DomainPWWP

BRPF3 NSD2

2.68e-0324602PS50812
DomainChromo_domain

CHD8 CHD7

2.68e-0324602IPR023780
DomainChromo

CHD8 CHD7

3.14e-0326602PF00385
DomainCHROMO_1

CHD8 CHD7

3.64e-0328602PS00598
DomainCHROMO_2

CHD8 CHD7

3.64e-0328602PS50013
DomainZnF_U1

TUT7 ZNF593

3.90e-0329602SM00451
DomainZnf_U1

TUT7 ZNF593

3.90e-0329602IPR003604
DomainHMGI/Y_DNA-bd_CS

EWSR1 ZNF653

4.44e-0331602IPR000637
DomainDEAD_ATP_HELICASE

DDX27 DDX5

4.44e-0331602PS00039
DomainChromodomain-like

CHD8 CHD7

4.73e-0332602IPR016197
DomainRNA-helicase_DEAD-box_CS

DDX27 DDX5

5.03e-0333602IPR000629
DomainChromo/shadow_dom

CHD8 CHD7

5.03e-0333602IPR000953
DomainCHROMO

CHD8 CHD7

5.03e-0333602SM00298
DomainDNA/RNA_helicase_DEAH_CS

CHD8 CHD7

5.64e-0335602IPR002464
DomainQ_MOTIF

DDX27 DDX5

6.29e-0337602PS51195
DomainRNA_helicase_DEAD_Q_motif

DDX27 DDX5

6.29e-0337602IPR014014
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

GANAB NSD2 NOP53 TUT7 SMARCA2 CHD8 EWSR1 FRYL PRPF6 CHD7 PLEC SNRNP200 DDX27

3.21e-10653671322586326
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

FLII GANAB NSD2 NOP53 RCN1 SMARCA2 CHD8 DCTN4 SNRNP200 DDX27

7.45e-08533671030554943
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

PCF11 SMARCA2 CHD8 PRPF6 CHD7 DIAPH3 PLEC SNRNP200 DDX5 KPNA1

1.68e-07582671020467437
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

FLII TUT7 SMARCA2 CHD8 PRPF6 CHD7 POLD3 PLEC DCTN4 SNRNP200 DDX27 DDX5 FAM83H KPNA1

2.41e-071353671429467282
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

NOP53 SMARCA2 CHD8 EWSR1 CHD7 SNRNP200 DDX27 KPNA1

1.24e-0641067826949251
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

PCF11 CHD8 EWSR1 CHD7 TAF1L SNRNP200 DDX5

1.26e-0628367730585729
Pubmed

Transcription factor protein interactomes reveal genetic determinants in heart disease.

ZBTB21 SMARCA2 CHD8 EWSR1 PRPF6 CHD7 SNRNP200 DDX5

1.26e-0641167835182466
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

FLII GANAB SH3GL1 RCN1 EWSR1 PRPF6 POLD3 PLEC DCTN4 SNRNP200 DDX5 KPNA1

1.79e-061149671235446349
Pubmed

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.

FLII GANAB NOP53 EWSR1 PRPF6 UPF3B PLEC ZNF593 SNRNP200 DDX27 DDX5

1.88e-06949671136574265
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

PCF11 TUT7 TSPYL2 SMARCA2 CHD8 PRPF6 DDX27 KPNA1

2.09e-0644067834244565
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

FLII GANAB SH3GL1 RCN1 EWSR1 PRPF6 UPF3B DIAPH3 PLEC ZNF593 SNRNP200 DDX5 KPNA1

2.59e-061415671328515276
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

FLII TUT7 SMARCA2 FRYL PLEC SNRNP200

2.65e-0620267633005030
Pubmed

An Exceptional Gene: Evolution of the TSPY Gene Family in Humans and Other Great Apes.

TSPY9 TSPY1

3.66e-06267224710137
Pubmed

Structure and function of TSPY, the Y-chromosome gene coding for the "testis-specific protein".

TSPY9 TSPY1

3.66e-0626729678360
Pubmed

Battle of the sexes: contrasting roles of testis-specific protein Y-encoded (TSPY) and TSPX in human oncogenesis.

TSPY9 TSPY1

3.66e-06267229974883
Pubmed

Colorectal carcinomas with CpG island methylator phenotype 1 frequently contain mutations in chromatin regulators.

CHD8 CHD7

3.66e-06267224211491
Pubmed

Role of the Y-located putative gonadoblastoma gene in human spermatogenesis.

TSPYL2 TSPY1

3.66e-06267221204751
Pubmed

Role for the EWS domain of EWS/FLI in binding GGAA-microsatellites required for Ewing sarcoma anchorage independent growth.

FLII EWSR1

3.66e-06267228847958
Pubmed

TSPY, the candidate gonadoblastoma gene on the human Y chromosome, has a widely expressed homologue on the X - implications for Y chromosome evolution.

TSPY9 TSPY1

3.66e-06267215241014
Pubmed

TSPY-related sequences represent a microheterogeneous gene family organized as constitutive elements in DYZ5 tandem repeat units on the human Y chromosome.

TSPY9 TSPY1

3.66e-0626728244388
Pubmed

The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatocellular carcinoma.

TSPYL2 TSPY1

3.66e-06267225017435
Pubmed

CHD8 interacts with CHD7, a protein which is mutated in CHARGE syndrome.

CHD8 CHD7

3.66e-06267220453063
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

FLII GANAB ZBTB21 RCN1 EWSR1 PRPF6 PLEC SNRNP200 DDX27 DDX5 FAM83H

3.89e-061024671124711643
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

FLII GANAB SH3GL1 RCN1 SMARCA2 EWSR1 PRPF6 UPF3B POLD3 DDX27 DDX5 FAM83H

4.15e-061247671227684187
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

PCF11 NOP53 TSPYL2 RCN1 EWSR1 PRPF6 DCTN4 SNRNP200 DDX27 DDX5

4.92e-06847671035850772
Pubmed

TRIM65 regulates microRNA activity by ubiquitination of TNRC6.

NOP53 ZBTB21 PRPF6 UPF3B POLD3 DDX27 KPNA1

6.59e-0636467724778252
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

GANAB SMARCA2 CHD8 EWSR1 PRPF6 CHD7 PLEC SNRNP200 DDX27 DDX5 FAM83H KPNA1

7.28e-061318671230463901
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF5 PRAMEF26 PRAMEF6

1.03e-052267331729367
Pubmed

Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8.

CHD8 CHD7

1.10e-05367230108144
Pubmed

The Y-located proto-oncogene TSPY exacerbates and its X-homologue TSPX inhibits transactivation functions of androgen receptor and its constitutively active variants.

TSPYL2 TSPY1

1.10e-05367228169398
Pubmed

The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities.

CHD8 CHD7

1.10e-05367228533432
Pubmed

Autism-linked CHD gene expression patterns during development predict multi-organ disease phenotypes.

CHD8 CHD7

1.10e-05367230277262
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

PCF11 NSD2 NOP53 CHD8 EWSR1 PRPF6 CHD7 TAF1L SNRNP200 DDX5

1.39e-05954671036373674
Pubmed

Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress.

PCF11 NSD2 EWSR1 PRPF6 DDX5

1.44e-0515967522751105
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

FLII NSD2 NOP53 TUT7 PRPF6 UPF3B SNRNP200 DDX27 DDX5

1.48e-0575967935915203
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF5 PRAMEF26 PRAMEF6

1.52e-052567337451217
Pubmed

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.

EWSR1 PRPF6 UPF3B ZNF593 SNRNP200 DDX27 DDX5

1.59e-0541767736537216
Pubmed

Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.

SMARCA2 CHD7 DDX27 KPNA1

1.61e-057867428611094
Pubmed

The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.

FLII ZBTB21 CHD8 PRPF6 CHD7 SNRNP200 DDX5 KPNA1

1.63e-0558367829844126
Pubmed

Nucleolar proteome dynamics.

NOP53 EWSR1 UPF3B PLEC SNRNP200 DDX27 DDX5

1.64e-0541967715635413
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

SMARCA2 ZBTB5 EWSR1 PRPF6 SNRNP200 DDX27 DDX5 KPNA1

2.12e-0560567828977666
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

PRAMEF5 PRAMEF26 PRAMEF6

2.16e-052867325089626
Pubmed

The human SWI/SNF subunit Brm is a regulator of alternative splicing.

SMARCA2 PRPF6

2.19e-05467216341228
Pubmed

Identification and characterization of FAM124B as a novel component of a CHD7 and CHD8 containing complex.

CHD8 CHD7

2.19e-05467223285124
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

FLII NOP53 TUT7 EWSR1 PRPF6 PLEC SNRNP200 DDX27 DDX5 FAM83H KPNA1

2.64e-051257671136526897
Pubmed

Methylation of the DNA/RNA-binding protein Kin17 by METTL22 affects its association with chromatin.

RCN1 SNRNP200 DDX5

2.67e-053067324140279
Pubmed

Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.

FLII RCN1 PRPF6 CHD7 PLEC DCTN4 SNRNP200 DDX5

2.70e-0562667833644029
Pubmed

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

RCN1 SMARCA2 PRPF6 SNRNP200 DDX5 KPNA1

2.71e-0530467632235678
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

NOP53 TSPYL2 CHD8 CHD7 UPF3B ZNF593 CLASRP

3.36e-0546967727634302
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

FLII GANAB NOP53 RCN1 EWSR1 PRPF6 DDX27 DDX5

3.64e-0565367833742100
Pubmed

TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma.

FLII EWSR1

3.64e-05567234329586
Pubmed

The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein.

TSPYL2 TSPY1

3.64e-05567218649364
Pubmed

TSPY and its X-encoded homologue interact with cyclin B but exert contrasting functions on cyclin-dependent kinase 1 activities.

TSPYL2 TSPY1

3.64e-05567218591933
Pubmed

Nuclear localization of Duplin, a beta-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway.

CHD8 KPNA1

3.64e-05567211744694
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

PCF11 GANAB NSD2 EWSR1 PRPF6 CHD7 PLEC ZNF593 SNRNP200 DDX5

4.04e-051082671038697112
Pubmed

A human MAP kinase interactome.

CCDC14 PRKCE CHD8 PLEC CCDC88B SNRNP200 DDX27

4.20e-0548667720936779
Pubmed

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

PRAMEF5 PRAMEF26 PRAMEF6

4.28e-053567319389355
Pubmed

CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.

FLII GANAB EWSR1 PRPF6 PLEC SNRNP200 DDX5

4.66e-0549467726831064
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

PCF11 ZBTB21 SMARCA2 CHD8 EWSR1 PRPF6 CHD7 UPF3B SNRNP200 DDX5

4.75e-051103671034189442
Pubmed

Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production.

EWSR1 PRPF6 SNRNP200 DDX5 KPNA1

4.98e-0520667522174317
Pubmed

The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions.

PRPF6 SNRNP200

5.46e-05667210788320
Pubmed

CHARGE and Kabuki syndromes: a phenotypic and molecular link.

CHD8 CHD7

5.46e-05667224705355
Pubmed

Comprehensive proteomic analysis of the human spliceosome.

PCF11 PRPF6 UPF3B SNRNP200

6.01e-0510967412226669
Pubmed

The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase.

RCN1 EWSR1 PRPF6 SNRNP200 DDX5

6.79e-0522067534091597
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

PCF11 GANAB RCN1 SMARCA2 PRPF6 DCTN4 SNRNP200 DDX5 FAM83H KPNA1

6.98e-051155671020360068
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

PCF11 NOP53 UPF3B ZNF593 CCDC88B CLASRP

7.02e-0536167626167880
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

PRAMEF5 RHBDF1 ZBTB5 CHD7 PLEC PRAMEF6

7.24e-0536367614691545
Pubmed

A conserved acetylation switch enables pharmacological control of tubby-like protein stability.

FLII SH3GL1 POLD3 MAST3 KPNA1

7.24e-0522367533187986
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

GANAB RCN1 CHD8 EWSR1 DIAPH3 POLD3 KPNA1

7.59e-0553467735032548
Pubmed

Amotl2 interacts with LL5β, localizes to podosomes and regulates postsynaptic differentiation in muscle.

FLII PLEC

7.63e-05767223525008
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

NSD2 NOP53 CHD8 PRPF6 PLEC TAF1L

8.04e-0537067622922362
Pubmed

Human transcription factor protein interaction networks.

PCF11 GANAB NOP53 ZBTB21 RCN1 SMARCA2 CHD8 EWSR1 CHD7 TAF1L DDX27

8.40e-051429671135140242
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

FLII GANAB SH3GL1 RCN1 FRYL POLD3 PLEC DCTN4 SNRNP200 DDX5 KPNA1

9.85e-051455671122863883
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

NOP53 SH3GL1 RCN1 EWSR1 PRPF6 PLEC SNRNP200 DDX27 DDX5

1.14e-0498967936424410
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

PCF11 FLII ZBTB21 SMARCA2 CHD7 PLEC SNRNP200 CLASRP

1.19e-0477467815302935
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

PCF11 RHBDF1 NSD2 NOP53 SMARCA2 CHD8 CHD7 ZNF593 TAF1L DDX27 KPNA1

1.27e-041497671131527615
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

SECISBP2L NOP53 TUT7 EWSR1 UPF3B SNRNP200 DDX27 DDX5

1.58e-0480767822681889
Pubmed

The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA.

UPF3B DDX5

1.63e-041067223788676
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

PCF11 ZBTB21 SMARCA2 CHD8 CHD7

1.71e-0426867533640491
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

PRPF6 PLEC SNRNP200 DDX5 KPNA1

1.83e-0427267531010829
Pubmed

Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.

FLII NSD2 SH3GL1 PRPF6 SNRNP200 DDX5

2.09e-0444167631239290
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

RCN1 SMARCA2 PRPF6 UPF3B PLEC SNRNP200 DDX5 KPNA1

2.20e-0484767835235311
Pubmed

A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein.

FLII SNRNP200 FAM83H

2.27e-046167319875381
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

CCDC14 GANAB SH3GL1 TUT7 PLEC DCTN4 DDX27 FAM83H

2.30e-0485367828718761
Pubmed

A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.

FLII SMARCA2 EWSR1 SNRNP200 DDX5

2.31e-0428667532041737
Pubmed

Baf60c is a component of the neural progenitor-specific BAF complex in developing retina.

SMARCA2 HES5

2.38e-041267218816825
Pubmed

Generation and comprehensive analysis of an influenza virus polymerase cellular interaction network.

DDX5 KPNA1

2.38e-041267221994455
Pubmed

WDFY4 is required for cross-presentation in response to viral and tumor antigens.

GANAB PLEC DCTN4 WDFY4

2.40e-0415667430409884
Pubmed

EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.

PLEC DDX5 FAM83H

2.50e-046367329162697
Pubmed

DDX39B facilitates the malignant progression of hepatocellular carcinoma via activation of SREBP1-mediated de novo lipid synthesis.

FLII PLEC DDX5

2.50e-046367337052853
Pubmed

Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases.

FLII EWSR1 PLEC DDX27 DDX5

2.67e-0429567526209609
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

BRPF3 NSD2 TSPYL2 ZBTB21 RCN1 SMARCA2 CHD8 FAM83H KPNA1

2.81e-04111667931753913
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

SECISBP2L PCF11 FLII TUT7 EWSR1 PRPF6 CHD7 UPF3B PLEC DDX27

2.81e-041371671036244648
Pubmed

The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP.

PRPF6 SNRNP200

2.81e-041367216723661
Pubmed

R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.

PRPF6 SNRNP200 DDX5 FAM83H KPNA1

2.88e-0430067528561026
Pubmed

Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.

PCF11 PLEC SNRNP200 DDX5

3.32e-0417067416159877
Pubmed

Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.

PPP1R2B FRYL PRPF6 KPNA1

3.63e-0417467429669786
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

FLII SMARCA2 PRPF6 DCTN4 SNRNP200 DDX5 KPNA1

4.10e-0470467729955894
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

PCF11 EWSR1 DDX5 KPNA1

4.12e-0418067435198878
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

PCF11 LMOD3 NSD2 ZBTB21 RCN1 PRPF6 DIAPH3 PLEC C2orf78 DDX5

4.19e-041442671035575683
InteractionTSPY8 interactions

TSPY3 TSPY2 TSPY8

2.77e-083623int:TSPY8
InteractionSIRT7 interactions

GANAB NSD2 NOP53 TUT7 SMARCA2 CHD8 EWSR1 FRYL PRPF6 CHD7 PLEC SNRNP200 DDX27

3.33e-077446213int:SIRT7
InteractionTHRAP3 interactions

NSD2 PRKCE EWSR1 PRPF6 UPF3B PLEC WDFY4 SNRNP200 PTTG1IP DDX5

9.21e-074436210int:THRAP3
InteractionCHD4 interactions

FLII GANAB NSD2 SMARCA2 ZBTB5 EWSR1 PRPF6 POLD3 DCTN4 SNRNP200 DDX27 DDX5 KPNA1

4.41e-069386213int:CHD4
InteractionDGCR8 interactions

FLII NSD2 NOP53 TUT7 EWSR1 DDX27 DDX5

9.25e-06242627int:DGCR8
InteractionSIRT6 interactions

PCF11 TUT7 TSPYL2 SMARCA2 CHD8 PRPF6 POLD3 SNRNP200 DDX27 KPNA1

2.00e-056286210int:SIRT6
InteractionLHX3 interactions

RHBDF1 SMARCA2 TSPY2 CHD7 TAF1L DDX27

2.21e-05185626int:LHX3
InteractionSUZ12 interactions

RCN1 SMARCA2 CHD8 EWSR1 CHD7 UPF3B PLEC ZNF593 SNRNP200 DDX5

2.49e-056446210int:SUZ12
InteractionHDAC1 interactions

FLII GANAB NSD2 ZBTB21 SMARCA2 ZBTB5 CHD8 DIAPH3 POLD3 PLEC DCTN4 DDX5 KPNA1

2.62e-0511086213int:HDAC1
InteractionGATA4 interactions

ZBTB21 SMARCA2 CHD8 EWSR1 PRPF6 CHD7 SNRNP200 DDX5

3.61e-05411628int:GATA4
InteractionLRRC31 interactions

FLII TUT7 SMARCA2 FRYL PLEC SNRNP200

3.94e-05205626int:LRRC31
InteractionCOIL interactions

NSD2 TSPYL2 ZBTB21 CHD8 PRPF6 CHD7 SNRNP200 CLASRP KPNA1

4.53e-05552629int:COIL
InteractionETV3 interactions

NOP53 EWSR1 CHD7 DDX27 CLASRP

4.63e-05128625int:ETV3
InteractionSRPK2 interactions

PCF11 NOP53 PRPF6 UPF3B ZNF593 CCDC88B SNRNP200 DDX27 DDX5 CLASRP

6.16e-057176210int:SRPK2
InteractionDDX23 interactions

NOP53 EWSR1 PRPF6 WDFY4 SNRNP200 DDX27 DDX5 CLASRP

1.07e-04480628int:DDX23
InteractionXRCC6 interactions

PCF11 GANAB NSD2 NOP53 CHD8 EWSR1 CHD7 TAF1L SNRNP200 DDX5 MAST3

1.10e-049286211int:XRCC6
InteractionSNRNP40 interactions

NSD2 NOP53 ZBTB21 EWSR1 PRPF6 SNRNP200 DDX27 DDX5 CLASRP

1.35e-04637629int:SNRNP40
InteractionPRKCSH interactions

FLII GANAB SH3GL1 EWSR1 UPF3B DCTN4

1.37e-04257626int:PRKCSH
InteractionTSPY3 interactions

TSPY3 TSPY8

1.39e-046622int:TSPY3
InteractionMKI67 interactions

NSD2 NOP53 SMARCA2 CHD8 EWSR1 CHD7 SNRNP200 DDX27 KPNA1

1.54e-04648629int:MKI67
InteractionCENPA interactions

NSD2 NOP53 SMARCA2 PRPF6 CHD7 DIAPH3 DDX5

1.54e-04377627int:CENPA
InteractionNHLH1 interactions

NOP53 ZBTB21 SMARCA2 DDX27

1.56e-0488624int:NHLH1
InteractionKAT6A interactions

BRPF3 EWSR1 PRPF6 UPF3B ZNF593 SNRNP200 DDX27 DDX5

1.62e-04510628int:KAT6A
InteractionPHAX interactions

PCF11 CHD8 EWSR1 SNRNP200 KPNA1

1.63e-04167625int:PHAX
InteractionRAB4B interactions

CHD8 PRPF6 SNRNP200

2.00e-0437623int:RAB4B
InteractionCIC interactions

FLII ZBTB21 CHD8 EWSR1 PRPF6 CHD7 SNRNP200 DDX5 KPNA1

2.04e-04673629int:CIC
InteractionCUL7 interactions

BRPF3 GANAB TUT7 RCN1 EWSR1 PRPF6 PLEC SNRNP200 DDX27 DDX5

2.37e-048456210int:CUL7
InteractionZNF692 interactions

NSD2 NOP53 DDX27

2.92e-0442623int:ZNF692
InteractionSRPK3 interactions

NSD2 NOP53 PRPF6 DDX27 KPNA1

2.96e-04190625int:SRPK3
InteractionTAF9B interactions

CHD8 EWSR1 TAF1L KPNA1

3.43e-04108624int:TAF9B
InteractionSLX4 interactions

NOP53 ZBTB21 ZBTB5 CHD8 PRPF6 SNRNP200 DDX5 KPNA1

3.52e-04572628int:SLX4
InteractionCCDC137 interactions

NSD2 NOP53 TUT7 TSPYL2 DDX27

3.74e-04200625int:CCDC137
InteractionCEBPB interactions

LINC00473 FLII RCN1 SMARCA2 EWSR1 PRPF6 CHD7 POLD3 PLEC SNRNP200 DDX27 DDX5 KPNA1

3.75e-0414436213int:CEBPB
CytobandYp11.2

TSPY4 TSPY3 TSPY10 TSPY2 TSPY9 TSPY8 TSPY1

9.45e-1194677Yp11.2
CytobandEnsembl 112 genes in cytogenetic band chrYp11

TSPY4 TSPY3 TSPY10 TSPY2 TSPY9 TSPY8 TSPY1

2.55e-09150677chrYp11
Cytoband1p36.21

PRAMEF5 PRAMEF26 PRAMEF6

1.11e-04636731p36.21
Cytoband11q12.3

GANAB CCDC88B

1.43e-033867211q12.3
GeneFamilyPRAME family

PRAMEF5 PRAMEF26 PRAMEF6

1.20e-0524343686
GeneFamilyPWWP domain containing

BRPF3 NSD2

7.74e-04223421147
GeneFamilyDEAD-box helicases

DDX27 DDX5

2.82e-0342342499
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Poorly_Differentiated_or_Epithelioid_Leiomyosarcoma-7|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

TSPY4 TSPY10 TSPY2 TSPY9 TSPY8

4.04e-07996754f0346fe85ba006d1ab28a61624568522ffe5cb4
ComputationalNeighborhood of GSTA4

BRPF3 NSD2 ZBTB5 DCTN4

5.22e-0568334GCM_GSTA4
ComputationalNeighborhood of MYST2

BRPF3 NSD2 ZBTB5 DCTN4 SNRNP200

1.63e-04172335GCM_MYST2
DiseaseCHARGE syndrome (implicated_via_orthology)

CHD8 CHD7

7.38e-057562DOID:0050834 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
KMDKGEHRQERRDRP

EWSR1

641

Q01844
APESSKKRARRMRPD

CHD8

2411

Q9HCK8
LADKVKRLMRPRREG

CCDC88B

1316

A6NC98
RPEREAMKRKAQQER

C2orf78

876

A6NCI8
MRKPRRKSRQNAEGR

BRPF3

1

Q9ULD4
RDRRKRTPMPKDVRQ

DIAPH3

1076

Q9NSV4
MKRGIRRDPFRKRKL

CCDC14

1

Q49A88
QEALMKTDRRRRRPR

CHD7

1931

Q9P2D1
KRNRRAKRARAMPEE

DDX27

716

Q96GQ7
LKLKFPRTEEERRMR

ATP8B1

821

O43520
VKNDKHSRRRRSMDP

ADAMTS6

61

Q9UKP5
KMLPRDERRFKAADL

RCN1

166

Q15293
ELVKARERPRPRKDM

ITPKC

496

Q96DU7
QRRNMIEPRERAKFK

NOP53

446

Q9NZM5
KDPMARKMRLRRRKD

FLII

421

Q13045
RKMRLRRRKDSAQDD

FLII

426

Q13045
MPRGQASKRRAREKR

MAGEB17

1

A8MXT2
RRKKARESERQMNSP

LRRTM4

466

Q86VH4
KRIQRKSRMPEAREP

LMOD3

491

Q0VAK6
DNEERVFRERMRPRK

PRKCE

141

Q02156
VFRERMRPRKRQGAV

PRKCE

146

Q02156
KRRCDELTRKMRRDG

DDX5

351

P17844
SLPRKERKRREEQMP

OPTC

21

Q9UBM4
EALERRPENMKRRRR

FRYL

961

O94915
REECIPMKRRRRAKL

NSD2

391

O96028
KRRDRRSPKRRQRSM

PCF11

496

O94913
VKRDRIRNKDRPAMQ

UPF3B

426

Q9BZI7
KERSMGSRQPRKRER

LINC00473

36

A8K010
KCDRMRSQKLRRRPD

CACNA2D4

1081

Q7Z3S7
PARKNVAKGRMARRS

MAST3

1046

O60307
RDRLLRRMESMRKEK

FAM83H

1116

Q6ZRV2
RDPKKRAAAMERVRQ

CCDC201

151

A0A1B0GTI1
ERDRKKLARRRNYMP

DCTN4

161

Q9UJW0
RAELMKRVRDLRHPK

PRAMEF26

341

H0Y7S4
MDMDRRREDARNPKR

SMARCA2

1256

P51531
RREDARNPKRKPRLM

SMARCA2

1261

P51531
KRLKRGSPRIEEMRA

TOP6BL

491

Q8N6T0
AALDKRMDERRKERR

PRPF6

106

O94906
KSKDRPRRIRMEDIK

TAF1L

836

Q8IZX4
NKSLNPDEMRRRREE

KPNA1

16

P52294
KNMTRFRIDELEPRR

GANAB

96

Q14697
RLPRRRKRESVAKMS

RHBDF1

201

Q96CC6
QKDPVRAKARRRLVM

SECISBP2L

706

Q93073
NMRKKRRRIKLPESD

POLD3

316

Q15054
KNRLRKPVVEKMRRD

HES5

16

Q5TA89
CPERRLRAAQEMARK

CLCN1

666

P35523
RAMARKIRMKERERR

CLASRP

616

Q8N2M8
ARRKREAREFKPPQM

C10orf67

51

Q8IYJ2
AELMKRVRDLRHPKR

PRAMEF6

436

Q5VXH4
FSRQREKMERRRKPQ

TSPY9

136

A0A494C1R9
EKMERRRKPQLDRRG

TSPY9

141

A0A494C1R9
SRQREKMERRRKPHL

TSPY10

131

P0CW01
KMERRRKPHLDRRGA

TSPY10

136

P0CW01
SRQREKMERRRKPHL

TSPY2

131

A6NKD2
KMERRRKPHLDRRGA

TSPY2

136

A6NKD2
KRRMREASSRPKREY

SH3GL1

241

Q99961
PEKRRRSKRSRVMDA

ZNF653

446

Q96CK0
DMSRLPAKRRFQADR

ZBTB21

476

Q9ULJ3
FSRQREKMERRRKPH

TSPY4

136

P0CV99
EKMERRRKPHLDRRG

TSPY4

141

P0CV99
PMRRLHKRKQSAEER

ZBTB5

186

O15062
KRKFIQMRRPFLERR

TSPYL2

241

Q9H2G4
SRQREKMERRRKPHL

TSPY1

131

Q01534
KMERRRKPHLDRRGA

TSPY1

136

Q01534
PEEREKKRQFEMRRK

PPP1R2B

131

Q6NXS1
AELMKRVRDLRHPKR

PRAMEF5

436

Q5TYX0
REGPARMRKRIKRLS

WDFY4

2291

Q6ZS81
SRKPDRSEEKAMRER

PTTG1IP

126

P53801
REGVMVAKKDRRPRS

PLEC

21

Q15149
SRQREKMERRRKPHL

TSPY3

131

P0CV98
KMERRRKPHLDRRGA

TSPY3

136

P0CV98
SRQREKMERRRKPHL

TSPY8

131

P0CW00
KMERRRKPHLDRRGA

TSPY8

136

P0CW00
ARQMKAKRRRPDLDE

ZNF593

16

O00488
PQMQEERRAKRRKRD

SNRNP200

61

O75643
RKQRRMCRRDPGVAE

WNT9A

66

O14904
FMKDCPMRRKVRRRR

TUT7

1356

Q5VYS8
PMRRKVRRRRDQEDA

TUT7

1361

Q5VYS8