Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	group II metabotropic glutamate receptor activity	GRM2 GRM3	1.27e-06	2	23	2	GO:0001641
GeneOntologyMolecularFunction	zinc ion sequestering activity	S100A7 S100A7A	7.60e-06	4	23	2	GO:0140486
GeneOntologyMolecularFunction	metal ion sequestering activity	S100A7 S100A7A	3.54e-05	8	23	2	GO:0140487
GeneOntologyMolecularFunction	G protein-coupled glutamate receptor activity	GRM2 GRM3	4.55e-05	9	23	2	GO:0098988
GeneOntologyMolecularFunction	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	GRM2 GRM3	4.55e-05	9	23	2	GO:0001640
GeneOntologyMolecularFunction	RAGE receptor binding	S100A7 S100A7A	1.32e-04	15	23	2	GO:0050786
GeneOntologyMolecularFunction	scaffold protein binding	GRM2 GRM3 MYH9	1.62e-04	93	23	3	GO:0097110
GeneOntologyMolecularFunction	glutamate receptor activity	GRM2 GRM3	4.38e-04	27	23	2	GO:0008066
GeneOntologyMolecularFunction	microfilament motor activity	MYH9 MYH13	8.70e-04	38	23	2	GO:0000146
GeneOntologyMolecularFunction	G-protein alpha-subunit binding	MYH9 HTR1A	1.11e-03	43	23	2	GO:0001965
GeneOntologyMolecularFunction	calcium channel regulator activity	GRM2 GRM3	1.75e-03	54	23	2	GO:0005246
GeneOntologyMolecularFunction	chemoattractant activity	S100A7 S100A7A	1.75e-03	54	23	2	GO:0042056
GeneOntologyMolecularFunction	molecular sequestering activity	S100A7 S100A7A	2.09e-03	59	23	2	GO:0140313
GeneOntologyMolecularFunction	ATP-dependent activity	MYH9 IDE HSP90AB3P MYH13	4.92e-03	614	23	4	GO:0140657
GeneOntologyMolecularFunction	calcium-dependent protein binding	S100A7 S100A7A	5.64e-03	98	23	2	GO:0048306
GeneOntologyBiologicalProcess	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	GRM2 GRM3	4.26e-05	9	23	2	GO:0007196
GeneOntologyBiologicalProcess	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	GRM2 GRM3 HTR1A	1.17e-04	86	23	3	GO:0007193
GeneOntologyBiologicalProcess	G protein-coupled glutamate receptor signaling pathway	GRM2 GRM3	1.41e-04	16	23	2	GO:0007216
GeneOntologyBiologicalProcess	negative regulation of adenylate cyclase activity	GRM2 GRM3	1.80e-04	18	23	2	GO:0007194
GeneOntologyBiologicalProcess	negative regulation of cyclase activity	GRM2 GRM3	2.01e-04	19	23	2	GO:0031280
GeneOntologyBiologicalProcess	negative regulation of lyase activity	GRM2 GRM3	2.71e-04	22	23	2	GO:0051350
GeneOntologyCellularComponent	astrocyte projection	GRM2 GRM3	3.42e-04	25	23	2	GO:0097449
GeneOntologyCellularComponent	myosin filament	MYH9 MYH13	3.42e-04	25	23	2	GO:0032982
GeneOntologyCellularComponent	myosin II complex	MYH9 MYH13	4.30e-04	28	23	2	GO:0016460
GeneOntologyCellularComponent	glial cell projection	GRM2 GRM3	1.21e-03	47	23	2	GO:0097386
Domain	S100A7	S100A7 S100A7A	1.20e-06	2	21	2	IPR028477
Domain	GPCR_3_mtglu_rcpt	GRM2 GRM3	3.36e-05	8	21	2	IPR000162
Domain	GPCR_3_9-Cys_dom	GRM2 GRM3	9.32e-05	13	21	2	IPR011500
Domain	NCD3G	GRM2 GRM3	9.32e-05	13	21	2	PF07562
Domain	GPCR_3_CS	GRM2 GRM3	1.09e-04	14	21	2	IPR017979
Domain	Myosin_N	MYH9 MYH13	1.25e-04	15	21	2	IPR004009
Domain	Myosin_N	MYH9 MYH13	1.25e-04	15	21	2	PF02736
Domain	Myosin_tail_1	MYH9 MYH13	1.82e-04	18	21	2	PF01576
Domain	Myosin_tail	MYH9 MYH13	1.82e-04	18	21	2	IPR002928
Domain	Myosin-like_IQ_dom	MYH9 MYH13	2.04e-04	19	21	2	IPR027401
Domain	-	MYH9 MYH13	2.04e-04	19	21	2	4.10.270.10
Domain	GPCR_3	GRM2 GRM3	2.50e-04	21	21	2	IPR000337
Domain	G_PROTEIN_RECEP_F3_4	GRM2 GRM3	2.74e-04	22	21	2	PS50259
Domain	7tm_3	GRM2 GRM3	2.74e-04	22	21	2	PF00003
Domain	GPCR_3_C	GRM2 GRM3	2.74e-04	22	21	2	IPR017978
Domain	G_PROTEIN_RECEP_F3_2	GRM2 GRM3	2.74e-04	22	21	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GRM2 GRM3	2.74e-04	22	21	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GRM2 GRM3	2.74e-04	22	21	2	PS00979
Domain	S100_CABP	S100A7 S100A7A	4.16e-04	27	21	2	PS00303
Domain	S_100	S100A7 S100A7A	4.16e-04	27	21	2	PF01023
Domain	S_100	S100A7 S100A7A	4.47e-04	28	21	2	SM01394
Domain	S100_Ca-bd_sub	S100A7 S100A7A	4.47e-04	28	21	2	IPR013787
Domain	S100/CaBP-9k_CS	S100A7 S100A7A	4.47e-04	28	21	2	IPR001751
Domain	ANF_receptor	GRM2 GRM3	7.83e-04	37	21	2	PF01094
Domain	ANF_lig-bd_rcpt	GRM2 GRM3	7.83e-04	37	21	2	IPR001828
Domain	MYOSIN_MOTOR	MYH9 MYH13	8.26e-04	38	21	2	PS51456
Domain	Myosin_head	MYH9 MYH13	8.26e-04	38	21	2	PF00063
Domain	Myosin_head_motor_dom	MYH9 MYH13	8.26e-04	38	21	2	IPR001609
Domain	MYSc	MYH9 MYH13	8.26e-04	38	21	2	SM00242
Domain	Peripla_BP_I	GRM2 GRM3	8.70e-04	39	21	2	IPR028082
Domain	EF_Hand_1_Ca_BS	EFCAB6 S100A7 S100A7A	9.50e-04	175	21	3	IPR018247
Domain	UBA	NUB1 USP24	1.11e-03	44	21	2	IPR015940
Domain	UBA	NUB1 USP24	1.26e-03	47	21	2	PS50030
Domain	EF_HAND_1	EFCAB6 S100A7 S100A7A	1.48e-03	204	21	3	PS00018
Domain	EF_HAND_2	EFCAB6 S100A7 S100A7A	2.11e-03	231	21	3	PS50222
Domain	EF_hand_dom	EFCAB6 S100A7 S100A7A	2.13e-03	232	21	3	IPR002048
Domain	UBA-like	NUB1 USP24	2.33e-03	64	21	2	IPR009060
Domain	IQ	MYH9 MYH13	2.86e-03	71	21	2	PF00612
Domain	-	EFCAB6 S100A7 S100A7A	2.98e-03	261	21	3	1.10.238.10
Domain	IQ	MYH9 MYH13	3.70e-03	81	21	2	SM00015
Domain	EF-hand-dom_pair	EFCAB6 S100A7 S100A7A	3.89e-03	287	21	3	IPR011992
Domain	IQ_motif_EF-hand-BS	MYH9 MYH13	4.54e-03	90	21	2	IPR000048
Domain	IQ	MYH9 MYH13	4.84e-03	93	21	2	PS50096
Domain	EF-hand_1	S100A7 S100A7A	1.25e-02	152	21	2	PF00036
Pathway	REACTOME_METAL_SEQUESTRATION_BY_ANTIMICROBIAL_PROTEINS	S100A7 S100A7A	2.05e-05	6	17	2	M27622
Pathway	WP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE	GRM2 GRM3	1.42e-04	15	17	2	M39442
Pathway	WP_GPCRS_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE	GRM2 GRM3	1.42e-04	15	17	2	MM15845
Pathway	REACTOME_ANTIMICROBIAL_PEPTIDES	S100A7 S100A7A DEFB106A	2.06e-04	98	17	3	M27627
Pathway	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	GRM2 GRM3	8.89e-04	37	17	2	MM15067
Pathway	REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS	GRM2 GRM3	9.88e-04	39	17	2	M793
Pubmed	Selective silencing of individual dendritic branches by an mGlu2-activated potassium conductance in dentate gyrus granule cells.	GRM2 GRM3	4.18e-07	2	23	2	23616537
Pubmed	Expression and subcellular distribution of glutamate receptor subunits 2/3 in the developing cerebellar cortex.	GRM2 GRM3	4.18e-07	2	23	2	8838577
Pubmed	Activation of Group II Metabotropic Glutamate Receptors Promotes LTP Induction at Schaffer Collateral-CA1 Pyramidal Cell Synapses by Priming NMDA Receptors.	GRM2 GRM3	4.18e-07	2	23	2	27911756
Pubmed	Activation of metabotropic glutamate receptor type 2/3 supports the involvement of the hippocampal mossy fiber pathway on contextual fear memory consolidation.	GRM2 GRM3	4.18e-07	2	23	2	19638469
Pubmed	The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells.	GRM2 GRM3	4.18e-07	2	23	2	7965099
Pubmed	Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors.	GRM2 GRM3	4.18e-07	2	23	2	21628565
Pubmed	Group II metabotropic glutamate receptor blockade promotes stress resilience in mice.	GRM2 GRM3	4.18e-07	2	23	2	30939596
Pubmed	Metabotropic Glutamate Receptor 2/3 Activation Improves Motor Performance and Reduces Pathology in Heterozygous zQ175 Huntington Disease Mice.	GRM2 GRM3	4.18e-07	2	23	2	34330748
Pubmed	Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis.	GRM2 GRM3	4.18e-07	2	23	2	25434487
Pubmed	Regulation of cocaine-induced reinstatement by group II metabotropic glutamate receptors in the ventral tegmental area.	GRM2 GRM3	4.18e-07	2	23	2	21881873
Pubmed	Reduction of group II metabotropic glutamate receptors during development of benzodiazepine dependence.	GRM2 GRM3	4.18e-07	2	23	2	23392308
Pubmed	Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice.	GRM2 GRM3	4.18e-07	2	23	2	20970439
Pubmed	NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer's, and Ethanol Intoxication.	GRM2 GRM3	4.18e-07	2	23	2	28285415
Pubmed	Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: the metabotropic pathway.	GRM2 GRM3	4.18e-07	2	23	2	24080311
Pubmed	mGlu2/3 receptor in the prelimbic cortex is implicated in stress resilience and vulnerability in mice.	GRM2 GRM3	4.18e-07	2	23	2	34090896
Pubmed	Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice.	GRM2 GRM3	4.18e-07	2	23	2	24053122
Pubmed	Fractionation of spatial memory in GRM2/3 (mGlu2/mGlu3) double knockout mice reveals a role for group II metabotropic glutamate receptors at the interface between arousal and cognition.	GRM2 GRM3	4.18e-07	2	23	2	21832989
Pubmed	Altered hippocampal expression of glutamate receptors and transporters in GRM2 and GRM3 knockout mice.	GRM2 GRM3	4.18e-07	2	23	2	18720515
Pubmed	Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice.	GRM2 GRM3	4.18e-07	2	23	2	34217776
Pubmed	Metabotropic glutamate receptor 2/3 in the hippocampus of patients with mesial temporal lobe epilepsy, and of rats and mice after pilocarpine-induced status epilepticus.	GRM2 GRM3	4.18e-07	2	23	2	15246118
Pubmed	Adaptive Changes in Group 2 Metabotropic Glutamate Receptors Underlie the Deficit in Recognition Memory Induced by Methamphetamine in Mice.	GRM2 GRM3	4.18e-07	2	23	2	38969501
Pubmed	Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia.	GRM2 GRM3	4.18e-07	2	23	2	18853337
Pubmed	Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction.	GRM2 GRM3	4.18e-07	2	23	2	25583490
Pubmed	The role of group II metabotropic glutamate receptors in cognition and anxiety: comparative studies in GRM2(-/-), GRM3(-/-) and GRM2/3(-/-) knockout mice.	GRM2 GRM3	4.18e-07	2	23	2	25158312
Pubmed	Memantine-induced brain activation as a model for the rapid screening of potential novel antipsychotic compounds: exemplified by activity of an mGlu2/3 receptor agonist.	GRM2 GRM3	4.18e-07	2	23	2	21057775
Pubmed	Hippocampal mossy fiber long-term depression in Grm2/3 double knockout mice.	GRM2 GRM3	4.18e-07	2	23	2	21360593
Pubmed	Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice.	GRM2 GRM3	4.18e-07	2	23	2	22089319
Pubmed	The mGluR2/3 agonist LY379268 induced anti-reinstatement effects in rats exhibiting addiction-like behavior.	GRM2 GRM3	4.18e-07	2	23	2	23624743
Pubmed	The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection.	GRM2 GRM3	4.18e-07	2	23	2	17670976
Pubmed	Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light.	GRM2 GRM3	4.18e-07	2	23	2	25950516
Pubmed	The effect of mGlu2/3 receptors on synaptic activities to different types of GABAergic interneurons in the anterior cingulate cortex.	GRM2 GRM3	4.18e-07	2	23	2	32525061
Pubmed	Developmental expression of mGlu2 and mGlu3 in the mouse brain.	GRM2 GRM3	4.18e-07	2	23	2	27818290
Pubmed	Association analysis of group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population.	GRM2 GRM3	4.18e-07	2	23	2	19386277
Pubmed	Evaluation of 5-HT2A and mGlu2/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: effect of antidepressant treatment.	GRM2 GRM3	1.25e-06	3	23	2	25150943
Pubmed	S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways.	S100A7 S100A7A	1.25e-06	3	23	2	22158945
Pubmed	Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics.	GRM2 GRM3	1.25e-06	3	23	2	24949866
Pubmed	Comparative analysis of the physical properties of murine and human S100A7: Insight into why zinc piracy is mediated by human but not murine S100A7.	S100A7 S100A7A	1.25e-06	3	23	2	37769710
Pubmed	The mouse S100A15 ortholog parallels genomic organization, structure, gene expression, and protein-processing pattern of the human S100A7/A15 subfamily during epidermal maturation.	S100A7 S100A7A	1.25e-06	3	23	2	16528363
Pubmed	Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis.	S100A7 S100A7A	1.25e-06	3	23	2	15717926
Pubmed	Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells.	GRM2 GRM3	1.25e-06	3	23	2	34620856
Pubmed	Astrocytic PAR1 and mGluR2/3 control synaptic glutamate time course at hippocampal CA1 synapses.	GRM2 GRM3	1.25e-06	3	23	2	38864289
Pubmed	Pharmacogenetic analysis of the mGlu2/3 agonist LY2140023 monohydrate in the treatment of schizophrenia.	GRM2 GRM3	1.25e-06	3	23	2	21173788
Pubmed	mGlu2 and mGlu3 Negative Allosteric Modulators Divergently Enhance Thalamocortical Transmission and Exert Rapid Antidepressant-like Effects.	GRM2 GRM3	1.25e-06	3	23	2	31735403
Pubmed	Molecular cloning and characterization of alternatively spliced mRNA isoforms from psoriatic skin encoding a novel member of the S100 family.	S100A7 S100A7A	2.51e-06	4	23	2	12923069
Pubmed	Reciprocal negative regulation between S100A7/psoriasin and beta-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity.	S100A7 S100A7A	2.51e-06	4	23	2	18223693
Pubmed	Group II metabotropic glutamate receptor interactions with NHERF scaffold proteins: Implications for receptor localization in brain.	GRM2 GRM3	2.51e-06	4	23	2	28392297
Pubmed	Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system.	GRM2 GRM3	2.51e-06	4	23	2	29079293
Pubmed	Inhibition of presynaptic calcium transients in cortical inputs to the dorsolateral striatum by metabotropic GABA(B) and mGlu2/3 receptors.	GRM2 GRM3	2.51e-06	4	23	2	25781000
Pubmed	Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice.	GRM2 GRM3	2.51e-06	4	23	2	15619115
Pubmed	Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15.	S100A7 S100A7A	2.51e-06	4	23	2	18606705
Pubmed	Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: specific roles for mGlu2 in the amygdala and subcortical nuclei, and mGlu3 in the hippocampus.	GRM2 GRM3	2.51e-06	4	23	2	16733060
Pubmed	Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495.	GRM2 GRM3	2.51e-06	4	23	2	19477188
Pubmed	S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4.	S100A7 S100A7A	4.18e-06	5	23	2	17625598
Pubmed	Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress.	GRM2 GRM3	4.18e-06	5	23	2	29024663
Pubmed	Genomic and phylogenetic analysis of the S100A7 (Psoriasin) gene duplications within the region of the S100 gene cluster on human chromosome 1q21.	S100A7 S100A7A	4.18e-06	5	23	2	12664160
Pubmed	Molecular cloning, occurrence, and expression of a novel partially secreted protein "psoriasin" that is highly up-regulated in psoriatic skin.	S100A7 S100A7A	4.18e-06	5	23	2	1940442
Pubmed	Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q.	GRM2 GRM3	6.26e-06	6	23	2	8824806
Pubmed	Presynaptic inhibition upon CB1 or mGlu2/3 receptor activation requires ERK/MAPK phosphorylation of Munc18-1.	GRM2 GRM3	6.26e-06	6	23	2	27056679
Pubmed	Differential maturation of GIRK2-expressing neurons in the mouse cerebellum.	GRM2 GRM3	6.26e-06	6	23	2	23261870
Pubmed	Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion.	GRM2 GRM3	8.77e-06	7	23	2	9920659
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	UNK DAAM2 CGRRF1 C3orf20 MYH9 IDE USP24	1.08e-05	1242	23	7	30973865
Pubmed	Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins.	GRM2 GRM3	1.17e-05	8	23	2	11850456
Pubmed	Visfatin enhances the production of cathelicidin antimicrobial peptide, human β-defensin-2, human β-defensin-3, and S100A7 in human keratinocytes and their orthologs in murine imiquimod-induced psoriatic skin.	S100A7 S100A7A	1.17e-05	8	23	2	23499548
Pubmed	Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.	GRM2 GRM3	1.88e-05	10	23	2	9069281
Pubmed	Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin.	MYH9 MYH13	2.75e-05	12	23	2	8424456
Pubmed	Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology.	GRM2 GRM3	2.75e-05	12	23	2	12074840
Pubmed	The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.	GRM2 GRM3	2.75e-05	12	23	2	11891216
Pubmed	Gene from a psoriasis susceptibility locus primes the skin for inflammation.	S100A7 S100A7A	3.25e-05	13	23	2	21148126
Pubmed	Active conformation of the p97-p47 unfoldase complex.	MYH9 IDE	4.37e-05	15	23	2	35552390
Pubmed	Therapeutic Elimination of the Type 1 Interferon Receptor for Treating Psoriatic Skin Inflammation.	S100A7 S100A7A	4.37e-05	15	23	2	27369778
Pubmed	Probing the S100 protein family through genomic and functional analysis.	S100A7 S100A7A	5.66e-05	17	23	2	15203200
Pubmed	Otic mesenchyme cells regulate spiral ganglion axon fasciculation through a Pou3f4/EphA4 signaling pathway.	GRM2 GRM3	6.36e-05	18	23	2	22243746
Pubmed	S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature).	S100A7 S100A7A	6.36e-05	18	23	2	15336958
Pubmed	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	GRM2 GRM3 HTR1A	6.42e-05	118	23	3	19156168
Pubmed	An update of the S100 nomenclature.	S100A7 S100A7A	7.10e-05	19	23	2	16938360
Pubmed	BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms.	S100A7 S100A7A	9.59e-05	22	23	2	17276340
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRM2 GRM3	1.14e-04	24	23	2	35746896
Pubmed	Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors.	GRM2 GRM3	1.24e-04	25	23	2	31665922
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	NCOA2 S100A7 GTF2E2 MYH9	1.91e-04	444	23	4	34795231
Pubmed	Cellular substrates and pro-apoptotic function of the human HtrA4 protease.	S100A7 S100A7A MYH9	1.99e-04	173	23	3	31470122
Pubmed	Reverse engineering a mouse embryonic stem cell-specific transcriptional network reveals a new modulator of neuronal differentiation.	GTF2E2 MYH9	2.75e-04	37	23	2	23180766
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	NCOA2 DAAM2 IDE USP24	3.83e-04	533	23	4	25544563
Pubmed	Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.	GRM2 GRM3	4.07e-04	45	23	2	25979088
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	NCOA2 NUB1 MYH13	4.76e-04	233	23	3	37704626
Pubmed	Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions.	S100A7 IDE	6.30e-04	56	23	2	37059927
Interaction	SUSD3 interactions	S100A7 CGRRF1 S100A7A	2.46e-05	50	23	3	int:SUSD3
Interaction	ZNF674 interactions	S100A7 S100A7A	4.46e-05	9	23	2	int:ZNF674
Interaction	S100A7L2 interactions	S100A7 S100A7A	5.58e-05	10	23	2	int:S100A7L2
GeneFamily	Glutamate metabotropic receptors\|Protein phosphatase 1 regulatory subunits	GRM2 GRM3	1.79e-05	8	15	2	281
GeneFamily	Myosin heavy chains	MYH9 MYH13	6.70e-05	15	15	2	1098
GeneFamily	S100 calcium binding proteins\|EF-hand domain containing	S100A7 S100A7A	1.34e-04	21	15	2	459
GeneFamily	EF-hand domain containing	EFCAB6 S100A7 S100A7A	7.16e-04	219	15	3	863
Coexpression	GSE21927_EL4_VS_MCA203_TUMOR_MONOCYTES_DN	GRM2 C3orf20 S100A7A FAM228B	2.26e-05	193	23	4	M7586
Drug	CX546	GRM2 GRM3 HTR1A	1.03e-06	21	22	3	CID000002890
Drug	N-palmitoyl-l-methionine	GRM2 GRM3 HTR1A	1.19e-06	22	22	3	CID000486207
Drug	YM90K	GRM2 GRM3 HTR1A	1.37e-06	23	22	3	CID005486547
Drug	aptiganel	GRM2 GRM3 HTR1A	2.53e-06	28	22	3	CID000060839
Drug	batoprazine	HTR1A IDE	2.67e-06	3	22	2	CID000184839
Drug	LY 379268	GRM2 GRM3	2.67e-06	3	22	2	ctd:C118218
Drug	isospaglumic acid	GRM2 GRM3	2.67e-06	3	22	2	ctd:C027172
Drug	LY 341495	GRM2 GRM3	5.34e-06	4	22	2	ctd:C114624
Drug	hallucinogen	GRM2 GRM3 HTR1A	5.48e-06	36	22	3	CID000031374
Drug	CGS 19755	GRM2 GRM3 HTR1A	6.46e-06	38	22	3	CID000068736
Drug	Acamprosate	GRM2 GRM3	8.90e-06	5	22	2	DB00659
Drug	N-Ac-D-E	GRM2 GRM3 IDE	1.78e-05	53	22	3	CID000005255
Drug	azetidine-2,4-dicarboxylic acid	GRM2 GRM3	1.87e-05	7	22	2	CID000005370
Drug	13-methoxyibogamine	GRM2 GRM3 HTR1A	1.88e-05	54	22	3	CID000065749
Drug	cis-MCG-I	GRM2 GRM3	2.49e-05	8	22	2	CID003035584
Drug	phencyclidine	GRM2 GRM3 DAAM2 HTR1A	2.53e-05	181	22	4	CID000006468
Drug	AP-7	GRM2 GRM3 HTR1A	2.99e-05	63	22	3	CID000003122
Drug	1,3-cyclopentanedicarboxylic acid	GRM2 GRM3	3.20e-05	9	22	2	CID000107216
Drug	mM PEP	GRM2 GRM3	3.20e-05	9	22	2	CID005311462
Drug	AC1N21PP	GRM2 GRM3	3.20e-05	9	22	2	CID004014619
Drug	NS-105	GRM2 GRM3	3.99e-05	10	22	2	CID000198695
Drug	cyclobutylene AP5	GRM2 GRM3	4.88e-05	11	22	2	CID000126582
Drug	N-anisoyl-GABA	GRM2 HTR1A	4.88e-05	11	22	2	CID000155723
Drug	MK-771	HTR1A IDE	4.88e-05	11	22	2	CID000123992
Drug	Atpa	GRM2 GRM3	5.85e-05	12	22	2	CID000002252
Drug	AC1NSKBB	GRM2 GRM3	6.91e-05	13	22	2	CID005311256
Drug	bicyclo[3.1.0]hexane	GRM2 GRM3	6.91e-05	13	22	2	CID000067510
Drug	Mspg	GRM2 GRM3	6.91e-05	13	22	2	CID003964410
Drug	anpirtoline	HTR1A IDE	6.91e-05	13	22	2	CID000065854
Drug	MSOPPE	GRM2 GRM3	6.91e-05	13	22	2	CID005311463
Drug	Benzamide	GRM3 HTR1A IDE	7.61e-05	86	22	3	CID000002331
Drug	IPSP	GRM2 GRM3 HTR1A	7.87e-05	87	22	3	CID000022083
Drug	SDZ 216-525	HTR1A IDE	8.05e-05	14	22	2	CID003037456
Drug	2-methyl-6-styrylpyridine	GRM2 GRM3	8.05e-05	14	22	2	CID000235382
Drug	MTPG	GRM2 GRM3	8.05e-05	14	22	2	CID005311456
Drug	NBQX	GRM2 GRM3 HTR1A	8.71e-05	90	22	3	CID003272523
Drug	ethylglutamate	GRM2 GRM3	1.06e-04	16	22	2	CID000014241
Drug	repinotan	GRM3 HTR1A	1.06e-04	16	22	2	CID000198756
Drug	2-PMPA	GRM2 GRM3	1.06e-04	16	22	2	CID010130754
Drug	psilocybin	GRM2 HTR1A	1.20e-04	17	22	2	CID000010624
Drug	3HPG	GRM2 GRM3	1.20e-04	17	22	2	CID000001217
Drug	cyclothiazide	GRM2 GRM3 IDE	1.30e-04	103	22	3	CID000002910
Drug	S-acetyl	GRM2 GRM3	1.35e-04	18	22	2	CID000137849
Drug	acromelic acid A	GRM2 GRM3	1.35e-04	18	22	2	CID000108086
Drug	butyrophenone	HTR1A IDE	1.51e-04	19	22	2	CID000010315
Drug	aminocyclopentane	GRM2 GRM3	1.51e-04	19	22	2	CID000002906
Drug	LY382884	GRM2 GRM3	1.51e-04	19	22	2	CID000656723
Drug	4-carboxy-3-hydroxyphenylglycine	GRM2 GRM3	1.68e-04	20	22	2	CID000001297
Drug	cyclizine	GRM2 GRM3 IDE	1.85e-04	116	22	3	CID000006726
Drug	eltoprazine	HTR1A IDE	1.85e-04	21	22	2	CID000065853
Drug	AC1NBUB1	GRM2 GRM3	1.85e-04	21	22	2	CID004473866
Drug	ziram	GRM2 HTR1A	1.85e-04	21	22	2	CID000008722
Drug	3,4-dihydroxyphenylglycine	GRM2 GRM3	1.85e-04	21	22	2	CID000027915
Drug	anisamide	HTR1A IDE	2.03e-04	22	22	2	CID000075540
Drug	ibotenic acid	GRM2 GRM3 HTR1A	2.15e-04	122	22	3	CID000001233
Drug	MSOP	GRM2 GRM3	2.23e-04	23	22	2	CID003964633
Drug	CGP 39653	GRM2 GRM3	2.43e-04	24	22	2	CID006437837
Drug	2-chloro-N6-cyclopentyladenosine	GRM2 GRM3	2.43e-04	24	22	2	CID000001547
Drug	RS)-2-chloro-5-hydroxyphenylglycine	GRM2 GRM3	2.43e-04	24	22	2	CID003645780
Drug	AP-5	GRM2 GRM3 HTR1A	2.47e-04	128	22	3	CID000001216
Drug	aniracetam	GRM2 GRM3 HTR1A	2.59e-04	130	22	3	CID000002196
Drug	gavestinel	GRM2 GRM3	2.64e-04	25	22	2	CID006450546
Drug	AC1L1D63	GRM2 GRM3	2.64e-04	25	22	2	CID000002209
Drug	AC1NQH9B	GRM2 GRM3	2.86e-04	26	22	2	CID005221504
Drug	1pyn	GRM2 HTR1A	2.86e-04	26	22	2	CID000447968
Drug	1-(1-naphthyl)piperazine	HTR1A IDE	2.86e-04	26	22	2	CID000001342
Drug	CP-93,129	HTR1A IDE	3.08e-04	27	22	2	CID000124007
Drug	L-689,560	GRM2 GRM3	3.08e-04	27	22	2	CID000121918
Drug	AC1L1BOS	HTR1A IDE	3.32e-04	28	22	2	CID000051767
Drug	Fr235999	GRM2 HTR1A	3.32e-04	28	22	2	CID005288244
Drug	C-PP	GRM2 GRM3	3.32e-04	28	22	2	CID000001228
Drug	rhod-2	GRM2 GRM3	3.32e-04	28	22	2	CID000123669
Drug	WAY 100135	HTR1A IDE	3.56e-04	29	22	2	CID000115111
Drug	AC1NUW3V	GRM2 GRM3	3.56e-04	29	22	2	CID005462126
Drug	D02568	HTR1A IDE	3.56e-04	29	22	2	CID011954254
Drug	p-MPPI	HTR1A IDE	3.56e-04	29	22	2	CID000004658
Drug	ketobemidone	GRM2 GRM3	3.56e-04	29	22	2	CID000010101
Drug	nimodipine	GRM2 GRM3 HTR1A	3.57e-04	145	22	3	CID000004497
Drug	AC1Q5UBL	GRM2 GRM3 HTR1A	3.64e-04	146	22	3	CID000005466
Drug	LY293558	GRM2 GRM3	3.81e-04	30	22	2	CID000127894
Drug	AC1L32TU	GRM2 GRM3	3.81e-04	30	22	2	CID000107831
Drug	cis-2,3-piperidine dicarboxylic acid	GRM2 GRM3	3.81e-04	30	22	2	CID000001226
Drug	GYKI 53655	GRM2 GRM3	3.81e-04	30	22	2	CID000126757
Drug	PBDA	GRM2 GRM3	3.81e-04	30	22	2	CID000004408
Drug	LY235959	GRM2 GRM3	4.07e-04	31	22	2	CID000131938
Drug	eliprodil	GRM2 GRM3	4.07e-04	31	22	2	CID000060703
Drug	NPC 12626	GRM2 GRM3	4.07e-04	31	22	2	CID000108099
Drug	PDTC	GRM3 DEFB106A	4.07e-04	31	22	2	CID000105009
Drug	carbachol	GRM2 GRM3 MYH9 HTR1A MYH13	4.26e-04	688	22	5	CID000002551
Drug	cyclohexanecarboxamide	HTR1A IDE	4.34e-04	32	22	2	CID000014283
Drug	alpha-methyl-4-carboxyphenylglycine	GRM2 GRM3	4.34e-04	32	22	2	CID000001222
Drug	RU 24969	HTR1A IDE	4.34e-04	32	22	2	CID000108028
Drug	Anidulafungin	GRM2 GRM3 HTR1A	4.50e-04	157	22	3	CID000166548
Drug	pirenperone	GRM2 HTR1A	4.62e-04	33	22	2	CID000004847
Drug	TG-3	GRM2 GRM3	4.62e-04	33	22	2	CID000205489
Drug	1-aminoindan-1,5-dicarboxylic acid	GRM2 GRM3	4.62e-04	33	22	2	CID000002071
Drug	carvedilol	MYH9 HTR1A MYH13	4.84e-04	161	22	3	CID000002585
Drug	D-CPPene	GRM2 GRM3	4.91e-04	34	22	2	CID006435801
Drug	CPPG	GRM2 GRM3	4.91e-04	34	22	2	CID000002878
Drug	kainite	GRM2 GRM3	5.20e-04	35	22	2	CID000164810
Disease	Addicted to cocaine	GRM2 GRM3	1.59e-06	3	22	2	C0858355
Disease	Psychoses, Substance-Induced	GRM2 HTR1A	7.17e-05	17	22	2	C0033941
Disease	Psychoses, Drug	GRM2 HTR1A	1.10e-04	21	22	2	C0033937
Disease	Uncinate Epilepsy	GRM2 GRM3	1.33e-04	23	22	2	C0014558
Disease	Epilepsy, Temporal Lobe	GRM2 GRM3	1.33e-04	23	22	2	C0014556
Disease	Epilepsy, Benign Psychomotor, Childhood	GRM2 GRM3	1.33e-04	23	22	2	C0393672
Disease	Epilepsy, Lateral Temporal	GRM2 GRM3	1.33e-04	23	22	2	C0393682
Disease	Schizophrenia	GRM2 GRM3 DAAM2 HTR1A IDE	4.09e-04	883	22	5	C0036341
Disease	Alcoholic Intoxication, Chronic	GRM2 GRM3 HTR1A	1.00e-03	268	22	3	C0001973
Disease	Mood Disorders	GRM3 HTR1A	6.91e-03	168	22	2	C0525045

Protein segments in the cluster

Peptide	Gene	Start	Entry
KVKVNFNDCSFDLKP	FAM228B	231	P0C875
AFKTRKCPENFNEAK	GRM2	746	Q14416
FKTRKCPENFNEAKF	GRM3	756	Q14832
KDKAGQKCKPIDVFD	CENPU	31	Q71F23
DDAEKKLNLAQKCFK	NUB1	301	Q9Y5A7
YCSKKKEQEDPNKLA	DAAM2	81	Q86T65
APFDLFENKKKKNNI	HSP90AB3P	281	Q58FF7
FQKPKQLKDKADFCI	MYH9	556	P35579
FFNFKPPKNLKKADF	LRGUK	186	Q96M69
PAKNAFFDEKCNKLK	DEFB106A	16	Q8N104
EKFKKCIQQQDPAFK	EFCAB6	626	Q5THR3
QHCQEGKAPKKAFKF	C3orf20	361	Q8ND61
DFQNAFKKIIKCKFC	HTR1A	406	P08908
FKQDDKFFLPKACLN	IDE	561	P14735
FALCSQKEQDKDKPK	CGRRF1	316	Q99675
MKENFPNFLSACDKK	S100A7A	36	Q86SG5
DKKKILFFNDKSCQF	GTF2E2	196	P29084
DNFNFKPDKCAILKE	NCOA2	61	Q15596
MKENFPNFLSACDKK	S100A7	36	P31151
PFDSKKACFVADNKE	MYH13	31	Q9UKX3
LAQKCPAAKEYFKEN	USP24	2506	Q9UPU5
AEYLKNFKCQAKLKP	UNK	426	Q9C0B0
EPFKENDLLKQEKCK	ZFYVE16	426	Q7Z3T8