Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmethyl-CpG binding

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

2.12e-0831555GO:0008327
GeneOntologyBiologicalProcessDNA methylation-dependent constitutive heterochromatin formation

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

1.23e-0744565GO:0006346
GeneOntologyBiologicalProcessfacultative heterochromatin formation

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

3.85e-0755565GO:0140718
GeneOntologyBiologicalProcessheterochromatin formation

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

8.00e-05163565GO:0031507
GeneOntologyCellularComponentrod spherule

MPP4 PCLO

2.11e-053562GO:0044317
GeneOntologyCellularComponentcone cell pedicle

MPP4 PCLO

7.01e-055562GO:0044316
GeneOntologyCellularComponentsynaptic membrane

ERBB3 GRID2IP KCND1 MPP4 NIPSNAP1 LPAR2 ITGA3 IGSF21

1.52e-04583568GO:0097060
DomainMeCpG-bd_2/3_C_dom

MBD3L5 MBD3L2 MBD3L3 MBD3L4

1.86e-097524IPR025884
DomainMBD2/MBD3_p55-bd

MBD3L5 MBD3L2 MBD3L3 MBD3L4

1.86e-097524IPR032343
DomainMBD_C

MBD3L5 MBD3L2 MBD3L3 MBD3L4

1.86e-097524PF14048
DomainMBDa

MBD3L5 MBD3L2 MBD3L3 MBD3L4

1.86e-097524PF16564
DomainPDZ

GRID2IP ARHGAP23 MPP4 PCLO

8.22e-04151524PS50106
DomainPDZ

GRID2IP ARHGAP23 MPP4 PCLO

8.43e-04152524IPR001478
DomainPDZ

GRID2IP ARHGAP23 MPP4

7.11e-03141523PF00595
DomainPDZ

GRID2IP ARHGAP23 MPP4

8.11e-03148523SM00228
Domain-

HECW1 PIK3CG PCLO

8.11e-031485232.60.40.150
Domain-

GRID2IP ARHGAP23 MPP4

8.42e-031505232.30.42.10
DomainC2_dom

HECW1 PIK3CG PCLO

1.07e-02164523IPR000008
Pubmed

MBD3L1 and MBD3L2, two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3: characterization of MBD3L1 as a testis-specific transcriptional repressor.

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

5.92e-14657512504854
Pubmed

Haploid male germ cell- and oocyte-specific Mbd3l1 and Mbd3l2 genes are dispensable for early development, fertility, and zygotic DNA demethylation in the mouse.

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

5.92e-14657518942147
Pubmed

MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing.

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

2.93e-111557515701600
Pubmed

Endocrine resistance associated with activated ErbB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signaling pathways.

ERBB3 PIK3CG

5.51e-05757219609946
Pubmed

Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab.

ERBB3 PIK3CG

5.51e-05757218625725
Pubmed

Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation.

SUN1 MLH1

9.43e-05957228031483
Pubmed

The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.

SUN1 MLH1

1.72e-041257230718482
Pubmed

Multiple roles of integrin-α3 at the neuromuscular junction.

PCLO ITGA3

1.72e-041257228386022
Pubmed

Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype.

ERBB3 WNT4

2.37e-041457233500353
Pubmed

Human chromosome 7: DNA sequence and biology.

TMEM229A GRID2IP HECW1 PIK3CG PCLO ASB4

2.43e-0453657612690205
Pubmed

Foxl2 is required for commitment to ovary differentiation.

MLH1 WNT4

3.97e-041857215944199
Pubmed

SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.

HECW1 FBXL5

4.43e-041957221572392
Pubmed

GATA5 interacts with GATA4 and GATA6 in outflow tract development.

NPPA ERBB3

4.92e-042057221839733
Pubmed

The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.

STK17B MLH1 ITGA3

5.86e-049957319730683
Pubmed

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

THEM4 ADSL NIPSNAP1 GHITM PTRH1 HEMK1 MDH2

7.70e-0492657720877624
Pubmed

Submandibular parasympathetic gangliogenesis requires sprouty-dependent Wnt signals from epithelial progenitors.

ERBB3 WNT4

7.73e-042557225805134
Pubmed

A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney.

WNT4 ITGA3

8.36e-042657219060336
Pubmed

CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination.

SUN1 MLH1

9.02e-042757226158450
Pubmed

Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.

SUN1 MLH1

1.04e-032957238485951
Pubmed

The DNA sequence and biology of human chromosome 19.

MBD3L5 MBD3L3 MBD3L4 LPAR2

1.22e-0328457415057824
Pubmed

Lem2 is essential for cardiac development by maintaining nuclear integrity.

NPPA SUN1

1.27e-033257237067297
Pubmed

Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts.

LPAR2 PTGER2

1.35e-033357239002541
Pubmed

A mitochondrial protein compendium elucidates complex I disease biology.

THEM4 ADSL NIPSNAP1 GHITM PTRH1 HEMK1 MDH2

1.57e-03104757718614015
Pubmed

Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects.

NPPA ARHGAP28

1.60e-033657227606604
Cytoband19p13.2

MBD3L5 MBD3L2 MBD3L3 MBD3L4 MBD3L2B

1.00e-0522957519p13.2
CytobandEnsembl 112 genes in cytogenetic band chr19p13

MBD3L5 MBD3L2 MBD3L3 MBD3L4 LPAR2 MBD3L2B

4.59e-04797576chr19p13
Cytoband11q13.2

RIN1 CARNS1

1.58e-034757211q13.2
Cytoband3p21.3

MLH1 HEMK1

2.48e-03595723p21.3
GeneFamilyRho GTPase activating proteins|BCH domain containing

STARD13 ARHGAP23 ARHGAP28

1.45e-0450373721
GeneFamilyPDZ domain containing

GRID2IP ARHGAP23 MPP4 PCLO

2.56e-041523741220
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

HECW1 PCLO

2.46e-0336372823
ToppCellTracheal-10x3prime_v2-Stromal-Schwann|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

STARD13 XYLT1 RIN1 ERBB3 YRDC

5.59e-061995758dc65662c3ca1db2ba0091332f0658abc0afc5de
ToppCellTracheal-10x3prime_v2-Stromal-Schwann-Schwann_nonmyelinating|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

STARD13 XYLT1 RIN1 ERBB3 YRDC

5.59e-06199575a92718a3f1153b8d2196fd343ed5bc0ebc98cad7
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(RGS5+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SERPINE3 TMEM229A ITGA3 CARNS1

7.44e-05175574f5451c29c487b998778e50349b3d774d5e20fd28
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Cbln1_(VTA_(dorsal_VTA))-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ARHGAP28 PTGER2 KRT25

7.60e-05645731b75c6ea17ba7efa83ffe8ae07a863abcdad542c
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Npy_(Cortical_subplate_interneuron)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SKOR2 PTGER2 GPRIN2

7.60e-056457328acc0d394b8cd2fd93ae5e0801f0ff1dd4b16ac
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Cbln1_(VTA_(dorsal_VTA))|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

ARHGAP28 PTGER2 KRT25

7.60e-0564573275b4c418dc631a0925d6516cee6bf217cb7240a
ToppCellPosterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Cplx3-Inhibitory_Neuron.Gad1Gad2.Cplx3-Npy_(Cortical_subplate_interneuron)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SKOR2 PTGER2 GPRIN2

7.60e-056457361414e0fa2242f156f0f45f8733b831b7f965dd8
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB3 ARHGAP23 SLC45A3 CARNS1

8.84e-051835745472cdce6d99314d229418412acf1fff6340db7d
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RIN1 KDM5C NIPSNAP1 PTRH1

8.84e-0518357491079a11685dd466bd27a0cf5afbf3734c08a05e
ToppCellAT1-AT2_cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

STARD13 ERBB3 PCLO MMP23B

8.84e-051835746821dca076318115d360ff426eb1218cfe104063
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB3 ARHGAP23 SLC45A3 CARNS1

9.03e-051845745939527d24d299e562e707469c9123890edd76be
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB3 ARHGAP23 SLC45A3 CARNS1

9.03e-05184574a2191dd5546efd357b23e625beb3c5820476f243
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB3 ARHGAP23 SLC45A3 CARNS1

9.41e-05186574d57c40b3fe5cfc87e771df76533d9a3e94678b04
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB3 ARHGAP23 SLC45A3 CARNS1

9.61e-0518757497e520705491c8f52a32025311a9fa7b9176979a
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SERPINE3 MMP23B ITGA3 CARNS1

9.81e-0518857400c5259bcb83218b7d44f4d585d9b68ef49763ab
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-C|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SERPINE3 STK17B DSCR9 PTGER2

1.04e-0419157495ae42d145adb478d886a2259baacc713cd6587b
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-mesothelial_cell|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SERPINE3 MMP23B ITGA3 CARNS1

1.06e-041925742f539653a20006bef814e6b4acd1023d6fdad5c6
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ERBB3 CCNO RIPK4 WNT4

1.11e-041945746b286992d4bb56013c0ea5a7601d3476d806175a
ToppCellmedial-2-Hematologic-Myeloid_Dendritic_Type_2|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

XYLT1 KCND1 STK17B IGSF21

1.13e-0419557454a404ee1b97d0659fcffafb20d11f878ed453d4
ToppCellmedial-Hematologic-Myeloid_Dendritic_Type_2-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

XYLT1 KCND1 STK17B IGSF21

1.13e-0419557435a5302b8b3e76bc92dc38979400c979f0e86550
ToppCellmedial-Hematologic-Myeloid_Dendritic_Type_2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

XYLT1 KCND1 STK17B IGSF21

1.13e-04195574c0d1ecb378bb482a8e08d7065fcca07a65687dac
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SERPINE3 MMP23B ITGA3 CARNS1

1.13e-041955748a9d05f7a5397836b7dfb8ae4f7c4896042ac0fe
ToppCell5'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SERPINE3 MMP23B ITGA3 CARNS1

1.15e-04196574429de4119c8b2193c992d36a6af84f806730cbee
ToppCell5'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(RGS5+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SERPINE3 MMP23B ITGA3 CARNS1

1.15e-041965748c8a73d9d9581b8d9a9babfa93459d12fb9eb3ac
ToppCellSubstantia_nigra-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6_(Thalamus,_glutamatergic)-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

NPPA GRID2IP RIPK4

1.17e-0474573ef4c9eafc794c7d50aef28b37d21b52d3c511499
ToppCellSubstantia_nigra-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6_(Thalamus,_glutamatergic)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

NPPA GRID2IP RIPK4

1.17e-04745736ecbdf4186039a031410e09ecd5afa66b6d5e2dc
ToppCellAT1-AT2_cells|World / lung cells shred on cell class, cell subclass, sample id

ERBB3 MMP23B ITGA3 GPRIN2

1.20e-04198574a5b3617ea2ed4bffba59edcf6284799c2b3bbb29
Diseaselaryngeal squamous cell carcinoma (is_marker_for)

ERBB3 MLH1

4.92e-0419512DOID:2876 (is_marker_for)
DiseaseCarcinoma, Ovarian Epithelial

WNT4 MDH2

1.24e-0330512C4721610
DiseaseBreast Cancer, Familial

MCPH1 MLH1

1.24e-0330512C0346153
Diseasecongestive heart failure (implicated_via_orthology)

NPPA MDH2

2.30e-0341512DOID:6000 (implicated_via_orthology)
DiseaseGastric Adenocarcinoma

ERBB3 MLH1

2.77e-0345512C0278701

Protein segments in the cluster

PeptideGeneStartEntry
QRLSRAMSRCVLEPR

PTRH1

11

Q86Y79
RALLTAPRSLRRSSC

NPPA

116

P01160
KVSMCRSRSRSRSPR

ERBB3

1111

P21860
CCLALADRMLRVSRP

CCNO

286

P22674
PRTLMHLSRCAIRRT

ASB4

381

Q9Y574
RCCRPTLRERNALMF

BTBD6

116

Q96KE9
APLVETMLRRSARCL

CARNS1

376

A5YM72
VAVRLCRRSRAASMG

PCDHB18P

656

Q96TA0
FAAPSRCRFLRSVMS

KCND1

251

Q9NSA2
IRRLMGKPRRCSSAF

LIN9

166

Q5TKA1
STRRSIMPRLQLCRS

MCPH1

376

Q8NEM0
ALDRCSRMAPLLSRS

LPAR2

171

Q9HBW0
MLAARLVCLRTLPSR

GHITM

1

Q9H3K2
CIRELSSRRLQRMPV

HEMK1

96

Q9Y5R4
AMASPSRNSQSRRRC

HECW1

21

Q76N89
MLSALARPASAALRR

MDH2

1

P40926
RRAARSALPMRLTSC

MBD3L5

41

A6NJ08
VSRRRICRTNTMARA

PCLO

3746

Q9Y6V0
SRAPRAPRLMLCALA

ITGA3

6

P26006
PVLRLMRSVLCCRIS

PTGER2

321

P43116
RRAARSALPMRLTSC

MBD3L2B

41

A0A1B0GVZ6
RSMRLCRRKSHLSPL

MPP4

381

Q96JB8
MSLRLSSASRRSCPR

KRT25

1

Q7Z3Z0
RRAARSALPMRLTSC

MBD3L3

41

A6NE82
MRTAPSLRRCVCLLL

IGSF21

1

Q96ID5
PQPRSSLRASSMCRR

GRID2IP

491

A4D2P6
SLRASSMCRRSLRSQ

GRID2IP

496

A4D2P6
MGRICPVNSRARRLR

DSCR9

1

P59020
RSLLRSLPRRARCSA

GLI4

101

P10075
ACSHVPMRSARLLTR

CRIPAK

116

Q8N1N5
PMRSARLLTRAHAEC

CRIPAK

121

Q8N1N5
SSAMCRKAARTRLPR

FBXL5

566

Q9UKA1
LCRLRAPSAAAMQRS

GPRIN2

106

O60269
RRAARSALPMRLTSC

MBD3L4

41

A6NDZ8
RRAARSALPMRLTSC

MBD3L2

41

Q8NHZ7
MAPRLCSISVTARRL

NIPSNAP1

1

Q9BPW8
AREPRLMASCHRASR

STARD13

441

Q9Y3M8
GRRRPLLRSMSAAFC

RIN1

341

Q13671
VSSARRFARSPDLRM

TMEM229A

71

B2RXF0
SPRETRRALAAAFRM

MMP23B

106

O75900
CDARRRLMKRLCPSS

MMP23B

271

O75900
RNPMRSERCCSLARH

ADSL

296

P30566
MSRRRFDCRSISGLL

STK17B

1

O94768
SRKEMTAACTPRRRI

MLH1

486

P40692
RPRACSHLIRLMQRC

RIPK4

251

P57078
RMPRTLRRLFVAELC

SLC45A3

266

Q96JT2
ITVSSARRRARMLSP

ADGRD2

826

Q7Z7M1
NCRRRRRMKPRSAAA

PIK3CG

16

P48736
PTHRKTCSQRRRRAM

SENP3

116

Q9H4L4
MVAAPCARRLARRSH

XYLT1

1

Q86Y38
MLRSCAARLRTLGAL

THEM4

1

Q5T1C6
RKSIPRCRRINRMLS

ARHGAP28

41

Q9P2N2
RSCRFCVMSPLRTLL

RFPL3S

11

P0C7P2
ALASRPSRMEALRLR

ARHGAP23

1361

Q9P227
CRRRRLGSVMRPTED

USP35

606

Q9P2H5
TTSLRRARMDVFLPR

SERPINE3

286

A8MV23
ILRRAGAMPISSRRC

SKOR2

101

Q2VWA4
MSPRSCLRSLRLLVF

WNT4

1

P56705
MSRRSLRLATTACTL

SUN1

51

O94901
MSPARRCRGMRAAVA

YRDC

1

Q86U90
LCMRSRRPRLETILA

KDM5C

1246

P41229