Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	TRP_channel	TRPV1 TRPV5	5.30e-04	11	59	2	IPR004729
Domain	CARD	RIPK2 CASP5	1.14e-03	16	59	2	SM00114
Domain	Bromodomain_CS	BPTF CECR2	3.04e-03	26	59	2	IPR018359
Domain	CARD	RIPK2 CASP5	3.52e-03	28	59	2	PF00619
Domain	FN3_dom	CHL1 IL10RA TRIL PTPRB	4.29e-03	209	59	4	IPR003961
Domain	CARD	RIPK2 CASP5	4.30e-03	31	59	2	IPR001315
Domain	CARD	RIPK2 CASP5	4.86e-03	33	59	2	PS50209
Domain	PH	PLEKHM3 ARHGEF2 ARHGEF26 PLEKHD1	5.91e-03	229	59	4	PF00169
Domain	BROMODOMAIN_1	BPTF CECR2	6.09e-03	37	59	2	PS00633
Domain	Bromodomain	BPTF CECR2	6.41e-03	38	59	2	PF00439
Pubmed	Impaired renal calcium absorption in mice lacking calcium channel beta 3 subunits.	CACNB3 TRPV5	3.23e-06	2	63	2	19767875
Pubmed	α-secretase ADAM10 physically interacts with β-secretase BACE1 in neurons and regulates CHL1 proteolysis.	CHL1 ADAM10	9.68e-06	3	63	2	29325091
Pubmed	A molecular determinant of phosphoinositide affinity in mammalian TRPV channels.	TRPV1 TRPV5	9.68e-06	3	63	2	27291418
Pubmed	PARP-1 regulates the expression of caspase-11.	PARP1 CASP5	9.68e-06	3	63	2	21530491
Pubmed	CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L.	BPTF CECR2	9.68e-06	3	63	2	15640247
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	CEP170 BPTF PARP1 SETX PTPRB SYT17 GPATCH8	1.10e-05	420	63	7	28065597
Pubmed	Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions.	PTPRB CNTNAP1	1.93e-05	4	63	2	9118959
Pubmed	Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death.	CHL1 ADAM10	1.93e-05	4	63	2	14761956
Pubmed	Caspase-11 contributes to site-1 protease cleavage and SREBP1 activation in the inflammatory response of macrophages.	MBTPS1 CASP5	1.93e-05	4	63	2	36776855
Pubmed	TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex.	PARP1 TINF2	1.93e-05	4	63	2	15133513
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CEP170 SETX CARMIL2 RIPK2 PLEKHM3 ARHGEF2 DENND2B GLCCI1 GARRE1	2.40e-05	861	63	9	36931259
Pubmed	TRPV3 is a temperature-sensitive vanilloid receptor-like protein.	TRPV1 TRPV5	3.22e-05	5	63	2	12077606
Pubmed	Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1.	RIPK2 ARHGEF2	3.22e-05	5	63	2	21887730
Pubmed	Role and regulation of TRP channels in neutrophil granulocytes.	TRPV1 TRPV5	3.22e-05	5	63	2	12765698
Pubmed	Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.	KIF21B TNFSF18 TAGAP SNAPC4	6.01e-05	116	63	4	21102463
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CEP170 BPTF MBTPS1 CACNB3 PTPRB IQCN ARHGEF26 ZP3 DENND2B JMJD1C SLC25A37	6.77e-05	1489	63	11	28611215
Pubmed	Poly(ADP-ribose) polymerase 1 (PARP-1) binds to 8-oxoguanine-DNA glycosylase (OGG1).	PARP1 ARHGEF2	8.98e-05	8	63	2	22057269
Pubmed	Assignment of a disintegrin and metalloproteinase domain 10 (Adam10) gene to mouse chromosome 9.	IL10RA ADAM10	8.98e-05	8	63	2	9441766
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	BPTF PARP1 SETX ZFP91 GPATCH8 SNAPC4 JMJD1C	1.14e-04	608	63	7	36089195
Pubmed	Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death.	RIPK2 CASP5	1.15e-04	9	63	2	16920334
Pubmed	BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage.	SETX TINF2	1.15e-04	9	63	2	34112789
Pubmed	Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.	IL10RA TNFSF18 RIPK2 CASP5 CLASRP	1.17e-04	263	63	5	19773279
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	KIF21B PARP1 MBTPS1 TINF2 TRIM56 ELMOD3 MRPS18C TAF5L GPATCH8 SLC25A37	1.28e-04	1327	63	10	32694731
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	CEP170 FLG BPTF PARP1 SETX CECR2 TAF5L GPATCH8 ARHGEF2	1.38e-04	1082	63	9	38697112
Pubmed	Common genetic variants in candidate genes and risk of familial lymphoid malignancies.	IL10RA TNFSF18 RIPK2 CASP5	1.43e-04	145	63	4	19573080
Pubmed	Neuronal Ig/Caspr recognition promotes the formation of axoaxonic synapses in mouse spinal cord.	CHL1 CNTNAP1	2.11e-04	12	63	2	24411736
Pubmed	The mouse gap junction gene connexin29 is highly expressed in sciatic nerve and regulated during brain development.	GJB1 ZP3	2.11e-04	12	63	2	11501764
Pubmed	Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutation.	GJB1 CNTNAP1	2.90e-04	14	63	2	19244508
Pubmed	Annotation and analysis of 10,000 expressed sequence tags from developing mouse eye and adult retina.	ADAM10 PAIP1	3.34e-04	15	63	2	14519200
Pubmed	SLX4IP promotes RAP1 SUMOylation by PIAS1 to coordinate telomere maintenance through NF-κB and Notch signaling.	PARP1 TINF2	3.81e-04	16	63	2	34187905
Pubmed	Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus.	TNFSF18 TAGAP	4.32e-04	17	63	2	24999842
Pubmed	TRIB3‒GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target.	PARP1 ZFP91	4.85e-04	18	63	2	34729304
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	BPTF ZFP91 IQCN GPATCH8 ARHGEF2 SNAPC4 CLASRP	4.94e-04	774	63	7	15302935
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	CEP170 BPTF PARP1 SETX ZFP91 TAF5L ARHGEF2 JMJD1C	8.24e-04	1103	63	8	34189442
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	TRIL SETX ARHGEF2	8.56e-04	102	63	3	9734811
Pubmed	Mapping the expression of transient receptor potential channels across murine placental development.	TRPV1 TRPV5	8.69e-04	24	63	2	33884443
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CEP170 BPTF CECR2 TRIM56 ZFP91 TAF5L CUL7 GARRE1	8.89e-04	1116	63	8	31753913
Pubmed	International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.	TRPV1 TRPV5	9.43e-04	25	63	2	16382100
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	CEP170 PAIP1 GARRE1 JMJD1C	9.87e-04	242	63	4	34011540
Pubmed	No death without life: vital functions of apoptotic effectors.	PARP1 CASP5	1.02e-03	26	63	2	18309324
Pubmed	Human transcription factor protein interaction networks.	FLG BPTF ZFP91 MRPS18C TAF5L GPATCH8 CUL7 GARRE1 JMJD1C	1.04e-03	1429	63	9	35140242
Pubmed	An introduction to TRP channels.	TRPV1 TRPV5	1.10e-03	27	63	2	16460286
Pubmed	NANOG-dependent function of TET1 and TET2 in establishment of pluripotency.	BPTF JMJD1C	1.10e-03	27	63	2	23395962
Pubmed	USP7 Regulates Cytokinesis through FBXO38 and KIF20B.	TAF5L GPATCH8 JMJD1C	1.24e-03	116	63	3	30804394
Pubmed	Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.	BPTF PARP1 PAIP1	1.24e-03	116	63	3	21282530
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	FLG CASP5 ELMOD3 PLEKHD1 ADAM10 DENND2B	1.51e-03	686	63	6	29987050
Pubmed	Identification of Redox and Glucose-Dependent Txnip Protein Interactions.	PARP1 JMJD1C	1.55e-03	32	63	2	27437069
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	TRPV1 TRPV5	1.64e-03	33	63	2	19834762
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	PARP1 CARMIL2 ARHGEF2	1.68e-03	129	63	3	23022380
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CEP170 KIF21B PARP1 CNTNAP1 RIPK2 ARHGEF2 ARHGEF26	1.75e-03	963	63	7	28671696
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHM3 ARHGEF2 ARHGEF26 PLEKHD1	1.56e-03	206	44	4	682
GeneFamily	Transient receptor potential cation channels	TRPV1 TRPV5	2.10e-03	28	44	2	249
GeneFamily	WD repeat domain containing\|Caspase recruitment domain containing\|Apoptosome	RIPK2 CASP5	2.41e-03	30	44	2	959
Coexpression	GSE18893_CTRL_VS_TNF_TREATED_TCONV_2H_UP	KIF21B TINF2 CFAP119 GPATCH8 ADAM10 PAIP1	7.89e-06	200	62	6	M7295
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TAGAP CECR2 TMEM44 ADAM10 SLC25A37	3.84e-06	169	62	5	4e1322cc5e1733e9fb19e08f739a30206f43cea8
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP170 TAGAP ADAM10 PAIP1 JMJD1C	7.32e-06	193	62	5	06b65110db974f4ef90d3511ff34428976a52c9c
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP170 TAGAP ADAM10 PAIP1 JMJD1C	7.32e-06	193	62	5	9c16032bc03df8760ae199e8f19fdafa4c3f1827
ToppCell	facs-Brain_Myeloid-Hippocampus-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP170 TAGAP ADAM10 PAIP1 JMJD1C	7.32e-06	193	62	5	a4f91bca5eaa985982d33a528f7566ffde154d47
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP170 TAGAP ADAM10 PAIP1 JMJD1C	7.32e-06	193	62	5	b39d7feaac4ff8f7409cd3d15e8f3c6391367275
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IL10RA TAGAP RIPK2 JMJD1C SLC25A37	7.50e-06	194	62	5	dfe0ece81922bfd7c6673726d3ea2365cbdb5513
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEP170 TAGAP RIPK2 ADAM10 JMJD1C	7.89e-06	196	62	5	5fe6534af65d43eeacd4b031310242b4f706008b
ToppCell	Control_saline-Endothelial-Endothelial-Gen_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	BPTF SETX PTPRB GARRE1 JMJD1C	8.70e-06	200	62	5	3b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-1m-Mesenchymal-Mesoderm\|1m / Sample Type, Dataset, Time_group, and Cell type.	CNTNAP1 ALDH8A1 OSER1 SLC25A37 CLASRP	8.70e-06	200	62	5	c0ad32e9dd7f481c2665587fd8bd9fffc2e725f9
ToppCell	facs-Thymus-Epithelium-3m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARMIL2 PLEKHM3 ARHGEF26 GLCCI1	2.80e-05	125	62	4	6bdbbd47b699d836900bd055f2144cf960b5e7b6
Disease	granulocyte percentage of myeloid white cells	OSER1 SNAPC4 ARRDC2 GLCCI1 JMJD1C	2.16e-04	268	60	5	EFO_0007997
Disease	Ulcerative Colitis	IL10RA KIF21B RIPK2	2.91e-04	63	60	3	C0009324
Disease	Dermatitis	FLG PARP1	4.79e-04	16	60	2	C0011603

Protein segments in the cluster

Peptide	Gene	Start	Entry
HGSASVNSRWRRFPT	CEP170	1221	Q5SW79
ATVWSSNVGRVHRVA	ALDH8A1	421	Q9H2A2
VRHDRLWTTRVTGSS	CNTNAP1	626	P78357
AHVWRTQRKTISDSG	ELMOD3	296	Q96FG2
RQAWTGSSQRSSRHL	CACNB3	411	P54284
GSVQWSRHFSGRTIT	ADAM10	611	O14672
SRQSRHSGATRLAWE	DNM1P46	156	Q6ZS02
NSRLRSVVWDRNHTS	CARMIL2	636	Q6F5E8
VHTASRDDRSTWIRV	ARHGEF2	551	Q92974
RSHQRSASWGSADQL	GLCCI1	216	Q86VQ1
TQSERARWITALGHS	ARHGEF26	766	Q96DR7
RWSGSASRNHRGSAQ	FLG	961	P20930
RRQASSAVRDSGHWG	FLG	1051	P20930
EDSERWSGSASRNHR	FLG	3226	P20930
QSLRSGNWSERKSHR	DENND2B	551	P78524
SRHRGSSRGRWAAAQ	BPTF	41	Q12830
SHVWTRSRDPEGSSR	CECR2	571	Q9BXF3
ARGRAHVHWTESRSA	ARRDC2	51	Q8TBH0
VSQSHSKTLWGARGR	NFILZ	11	A0A5F9ZHS7
HLCRATTTIQSAWRG	IQCN	971	Q9H0B3
NRRLLWHGSRTTNFA	PARP1	856	P09874
RSVSGRHKAFSTWAS	OR5D14	231	Q8NGL3
SQATGSAARWRTRRT	EFCAB2	91	Q5VUJ9
NSTRHLSFRWTASEG	PTPRB	1096	P23467
RSVRLTWEAGADHNS	CHL1	626	O00533
SGFWHATGRHSSRRL	MBTPS1	171	Q14703
SWRAGVIRAVSHRDS	JMJD1C	36	Q15652
KRRSRSTTAHSWQRS	GPATCH8	971	Q9UKJ3
RNRSHDWSSLATRGL	CUL7	1121	Q14999
SGARSVSSIVRQWNR	KIF21B	861	O75037
HFRWDRFGRRNSSSS	POMC	81	P01189
RAVDGSRHSNWTVTN	IL10RA	101	Q13651
GHARSRSDITQVDWR	PLEKHM3	146	Q6ZWE6
ELRSSNWGRVHATST	PAIP1	371	Q9H074
HGSAARTRASVRTQW	CFAP119	36	A1A4V9
HNVSWRDRTRGSIFI	CASP5	366	P51878
NTHSQGGRRSAWVRN	DGAT2L6	61	Q6ZPD8
AVRSWRGAAEATSRL	GARRE1	226	O15063
SGVNRHSTAIGRVWL	GJB1	11	P08034
SGSHDRTARLWSFDR	TAF5L	401	O75529
THRTAVEQWHSLRSR	SYT17	446	Q9BSW7
RWKQSRTVHASGDSL	TAGAP	666	Q8N103
RTRSANSTLAQALHW	LMF2	611	Q9BU23
SQTQTRTWSVERRRH	SLC26A8	941	Q96RN1
SQHRSAISCIRTVWR	SLC25A37	176	Q9NYZ2
CGSETHHTRRNSRWD	SETX	2646	Q7Z333
SWHGSTRKSSRGAVR	OSER1	61	Q9NX31
THTVLWRRGCSQQVS	MRPS18C	31	Q9Y3D5
SGRHARSRSRSWSRS	CLASRP	411	Q8N2M8
SSANSSRWSLRAAGR	TDRP	151	Q86YL5
FSLRSSRVSGRHWKN	TRPV1	776	Q8NER1
SCRFHRRRSSTSWND	PLEKHD1	436	A6NEE1
RRVQSQWASTRGGHK	TINF2	266	Q9BSI4
LSHSRTQGAQRSSWK	TNFSF18	11	Q9UNG2
TVSSARHADWRVQVA	RIPK2	31	O43353
GADSASVRWAVREHR	TRIL	596	Q7L0X0
SRSPSGHWRAAAQRQ	TMEM44	231	Q2T9K0
SSGDSVARSHVQWLR	SNAPC4	706	Q5SXM2
GWRSSRTSVSRHRDT	ZFP91	151	Q96JP5
ASGRVVSIATRIRWH	TSPY26P	261	Q9H489
WSSGLTEHRRVHTRQ	ZNF726P1	141	Q15940
SQWSRSASRNRRHVT	ZP3	341	P21754
RWTSDLVRHQRTHTG	ZNF202	491	O95125
TASQSSSHRGWEILR	TRPV5	691	Q9NQA5
WRRALSLSQASHAVA	TRIM56	581	Q9BRZ2