Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	apolipoprotein receptor activity	ABCA1 LRP1	6.28e-05	3	92	2	GO:0030226
Domain	Anaphylatoxin_comp_syst	C4A C4B	2.27e-04	5	90	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	2.27e-04	5	90	2	IPR001840
Domain	TIMP-like_OB-fold	METRN C4A C4B	2.60e-04	26	90	3	IPR008993
Domain	-	EXOSC6 EXOSC8	3.40e-04	6	90	2	3.30.230.70
Domain	PNPase/RNase_PH_dom	EXOSC6 EXOSC8	3.40e-04	6	90	2	IPR027408
Domain	ANATO	C4A C4B	4.75e-04	7	90	2	SM00104
Domain	ANATO	C4A C4B	4.75e-04	7	90	2	PF01821
Domain	ExoRNase_PH_dom2	EXOSC6 EXOSC8	4.75e-04	7	90	2	IPR015847
Domain	ANAPHYLATOXIN_2	C4A C4B	4.75e-04	7	90	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	4.75e-04	7	90	2	PS01177
Domain	RNase_PH	EXOSC6 EXOSC8	4.75e-04	7	90	2	PF01138
Domain	Anaphylatoxin/fibulin	C4A C4B	4.75e-04	7	90	2	IPR000020
Domain	Thiol-ester_cl	C4A C4B	6.31e-04	8	90	2	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	6.31e-04	8	90	2	IPR019565
Domain	MacrogloblnA2_CS	C4A C4B	6.31e-04	8	90	2	IPR019742
Domain	A2M_N	C4A C4B	1.01e-03	10	90	2	PF01835
Domain	A2M_N	C4A C4B	1.01e-03	10	90	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	1.01e-03	10	90	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	1.01e-03	10	90	2	PS00477
Domain	A2M	C4A C4B	1.01e-03	10	90	2	PF00207
Domain	A2M_N_2	C4A C4B	1.01e-03	10	90	2	IPR011625
Domain	A2M_comp	C4A C4B	1.01e-03	10	90	2	IPR011626
Domain	A2M_N_2	C4A C4B	1.01e-03	10	90	2	PF07703
Domain	A2M_recep	C4A C4B	1.01e-03	10	90	2	PF07677
Domain	A2M_comp	C4A C4B	1.01e-03	10	90	2	PF07678
Domain	Macroglobln_a2	C4A C4B	1.01e-03	10	90	2	IPR001599
Domain	ExoRNase_PH_dom1	EXOSC6 EXOSC8	1.01e-03	10	90	2	IPR001247
Domain	ABC_transporter_CS	ABCA1 ABCC8 ABCD1	1.08e-03	42	90	3	IPR017871
Domain	TF_fork_head_CS_2	FOXK2 FOXF1 FOXF2	1.41e-03	46	90	3	IPR030456
Domain	TF_fork_head_CS_1	FOXK2 FOXF1 FOXF2	1.51e-03	47	90	3	IPR018122
Domain	ABC_tran	ABCA1 ABCC8 ABCD1	1.60e-03	48	90	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCA1 ABCC8 ABCD1	1.60e-03	48	90	3	PS50893
Domain	FH	FOXK2 FOXF1 FOXF2	1.70e-03	49	90	3	SM00339
Domain	FORK_HEAD_1	FOXK2 FOXF1 FOXF2	1.70e-03	49	90	3	PS00657
Domain	FORK_HEAD_2	FOXK2 FOXF1 FOXF2	1.70e-03	49	90	3	PS00658
Domain	ABC_TRANSPORTER_1	ABCA1 ABCC8 ABCD1	1.70e-03	49	90	3	PS00211
Domain	Fork_head_dom	FOXK2 FOXF1 FOXF2	1.70e-03	49	90	3	IPR001766
Domain	FORK_HEAD_3	FOXK2 FOXF1 FOXF2	1.70e-03	49	90	3	PS50039
Domain	Forkhead	FOXK2 FOXF1 FOXF2	1.70e-03	49	90	3	PF00250
Domain	EGF-type_Asp/Asn_hydroxyl_site	CELSR3 SLIT3 LRP1 NOTCH3	1.72e-03	106	90	4	IPR000152
Domain	ABC_transporter-like	ABCA1 ABCC8 ABCD1	1.80e-03	50	90	3	IPR003439
Domain	AGC-kinase_C	LATS1 RPS6KA2 GRK4	2.49e-03	56	90	3	IPR000961
Domain	AGC_KINASE_CTER	LATS1 RPS6KA2 GRK4	2.49e-03	56	90	3	PS51285
Domain	S_TK_X	LATS1 RPS6KA2 GRK4	2.49e-03	56	90	3	SM00133
Domain	C1_1	ARHGEF28 DGKZ ARHGEF2	2.62e-03	57	90	3	PF00130
Domain	EGF_CA	CELSR3 SLIT3 LRP1 NOTCH3	2.87e-03	122	90	4	SM00179
Domain	C345C	C4A C4B	2.98e-03	17	90	2	SM00643
Domain	EGF-like_Ca-bd_dom	CELSR3 SLIT3 LRP1 NOTCH3	3.05e-03	124	90	4	IPR001881
Domain	EGF	CELSR3 SLIT3 LRP1 NOTCH3	3.23e-03	126	90	4	PF00008
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	3.34e-03	18	90	2	IPR008930
Domain	ZF_DAG_PE_1	ARHGEF28 DGKZ ARHGEF2	3.65e-03	64	90	3	PS00479
Domain	ZF_DAG_PE_2	ARHGEF28 DGKZ ARHGEF2	3.65e-03	64	90	3	PS50081
Domain	NTR	C4A C4B	3.72e-03	19	90	2	PF01759
Domain	Netrin_module_non-TIMP	C4A C4B	3.72e-03	19	90	2	IPR018933
Domain	C1	ARHGEF28 DGKZ ARHGEF2	3.81e-03	65	90	3	SM00109
Domain	PE/DAG-bd	ARHGEF28 DGKZ ARHGEF2	3.98e-03	66	90	3	IPR002219
Domain	AAA+_ATPase	ABCA1 ABCC8 ABCD1 SNRNP200	5.19e-03	144	90	4	IPR003593
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MST1R LIME1 FOXK2 CELSR3 SBF1 RPS6KA2 EXOSC6 LRRC56 NLRC5 MUS81 EXOSC8 IRS1 ABCD1 ARHGEF2	1.84e-06	1105	95	14	35748872
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	7.38e-06	2	95	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	7.38e-06	2	95	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	7.38e-06	2	95	2	15998580
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	7.38e-06	2	95	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	7.38e-06	2	95	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	7.38e-06	2	95	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	7.38e-06	2	95	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	7.38e-06	2	95	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	7.38e-06	2	95	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	7.38e-06	2	95	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	7.38e-06	2	95	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	7.38e-06	2	95	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	7.38e-06	2	95	2	12207352
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	7.38e-06	2	95	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	7.38e-06	2	95	2	6559257
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	7.38e-06	2	95	2	27758680
Pubmed	Yeast kinetochore microtubule dynamics analyzed by high-resolution three-dimensional microscopy.	ABCA1 GOPC	7.38e-06	2	95	2	16192284
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	7.38e-06	2	95	2	22387014
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	7.38e-06	2	95	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	7.38e-06	2	95	2	20506482
Pubmed	Differences in the embryonic expression patterns of mouse Foxf1 and -2 match their distinct mutant phenotypes.	FOXF1 FOXF2	7.38e-06	2	95	2	14745957
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	7.38e-06	2	95	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	7.38e-06	2	95	2	26800705
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	7.38e-06	2	95	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	7.38e-06	2	95	2	23918728
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	7.38e-06	2	95	2	15390104
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	7.38e-06	2	95	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	7.38e-06	2	95	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	7.38e-06	2	95	2	4216347
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	7.38e-06	2	95	2	1699796
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	7.38e-06	2	95	2	6950384
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	7.38e-06	2	95	2	2997024
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	7.38e-06	2	95	2	8660986
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	7.38e-06	2	95	2	3624865
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	7.38e-06	2	95	2	8428773
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	7.38e-06	2	95	2	21857912
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	7.38e-06	2	95	2	24638111
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	7.38e-06	2	95	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	7.38e-06	2	95	2	4514997
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	7.38e-06	2	95	2	21345967
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	7.38e-06	2	95	2	5919331
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	7.38e-06	2	95	2	3167981
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	7.38e-06	2	95	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	7.38e-06	2	95	2	30041577
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	7.38e-06	2	95	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	7.38e-06	2	95	2	2302180
Pubmed	Macrophage mitochondrial damage from StAR transport of 7-hydroperoxycholesterol: implications for oxidative stress-impaired reverse cholesterol transport.	ABCA1 STAR	7.38e-06	2	95	2	24269887
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	7.38e-06	2	95	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	7.38e-06	2	95	2	34358307
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	7.38e-06	2	95	2	18360261
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	7.38e-06	2	95	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	7.38e-06	2	95	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	7.38e-06	2	95	2	29080553
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	7.38e-06	2	95	2	26814963
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	7.38e-06	2	95	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	7.38e-06	2	95	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	7.38e-06	2	95	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	7.38e-06	2	95	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	7.38e-06	2	95	2	6149581
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	7.38e-06	2	95	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	7.38e-06	2	95	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	7.38e-06	2	95	2	2387317
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	7.38e-06	2	95	2	8132550
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	7.38e-06	2	95	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	7.38e-06	2	95	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	7.38e-06	2	95	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	7.38e-06	2	95	2	6167582
Pubmed	Forkhead transcription factor FoxF2 is expressed in mesodermal tissues involved in epithelio-mesenchymal interactions.	FOXF1 FOXF2	7.38e-06	2	95	2	10822266
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	7.38e-06	2	95	2	16908004
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	7.38e-06	2	95	2	1438267
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	7.38e-06	2	95	2	7365238
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	7.38e-06	2	95	2	19150565
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	7.38e-06	2	95	2	7391573
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	7.38e-06	2	95	2	17506029
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	7.38e-06	2	95	2	17971360
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	7.38e-06	2	95	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	7.38e-06	2	95	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	7.38e-06	2	95	2	2993295
Pubmed	Gastroparesis is associated with decreased FOXF1 and FOXF2 in humans, and loss of FOXF1 and FOXF2 results in gastroparesis in mice.	FOXF1 FOXF2	7.38e-06	2	95	2	30565344
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	7.38e-06	2	95	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	7.38e-06	2	95	2	17971229
Pubmed	Overexpression of Foxf2 in adipose tissue is associated with lower levels of IRS1 and decreased glucose uptake in vivo.	IRS1 FOXF2	7.38e-06	2	95	2	20009030
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	7.38e-06	2	95	2	6881182
Pubmed	Identification of the site of sulfation of the fourth component of human complement.	C4A C4B	7.38e-06	2	95	2	3944109
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	7.38e-06	2	95	2	17921792
Pubmed	Long noncoding RNA FER1L4 regulates rheumatoid arthritis via targeting NLRC5.	FER1L4 NLRC5	7.38e-06	2	95	2	31694750
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	7.38e-06	2	95	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	7.38e-06	2	95	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	7.38e-06	2	95	2	35898513
Pubmed	Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.	C4A C4B	7.38e-06	2	95	2	33353966
Pubmed	Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).	C4A C4B	7.38e-06	2	95	2	3008092
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	7.38e-06	2	95	2	28873507
Pubmed	The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4.	C4A C4B	7.38e-06	2	95	2	6609966
Pubmed	Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes.	C4A C4B	7.38e-06	2	95	2	2900855
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	7.38e-06	2	95	2	276882
Pubmed	Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1.	RNASEH1 NONO	7.38e-06	2	95	2	31495875
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	7.38e-06	2	95	2	6832377
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	7.38e-06	2	95	2	3794341
Pubmed	Complement and c4 null alleles in severe chronic adult periodontitis.	C4A C4B	7.38e-06	2	95	2	17257223
GeneFamily	Forkhead boxes	FOXK2 FOXF1 FOXF2	3.71e-04	43	59	3	508
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	3.71e-04	9	59	2	1234
GeneFamily	Exosome complex	EXOSC6 EXOSC8	6.77e-04	12	59	2	817
Drug	furore	NUTM1 GRK4 C4A TIMELESS	1.96e-06	22	95	4	CID000047938
Disease	pantothenate measurement	DFFB ABCA1	2.66e-04	8	92	2	EFO_0021034
Disease	congenital diaphragmatic hernia (implicated_via_orthology)	SLIT3 LRP1	6.22e-04	12	92	2	DOID:3827 (implicated_via_orthology)
Disease	Migraine Disorders	LRP1 NOTCH3	7.33e-04	13	92	2	C0149931
Disease	age at last pregnancy measurement	MST1R LONRF2	8.54e-04	14	92	2	EFO_0009440
Disease	C-reactive protein measurement	MST1R LIME1 DFFB ABCA1 NR1I2 LATS1 TRANK1 ARHGEF28 MACF1 DGKZ RIPOR3	1.32e-03	1206	92	11	EFO_0004458
Disease	descending aortic diameter	ABCC8 LRP1 MICA	2.66e-03	88	92	3	EFO_0021788
Disease	pallidum volume change measurement, age at assessment	SLIT3 MICA	2.75e-03	25	92	2	EFO_0008007, EFO_0021494

Protein segments in the cluster

Peptide	Gene	Start	Entry
AGRRGQDCRRLAKEL	CCDC61	241	Q9Y6R9
ELRCKIPAGRLRRAA	ANKRD54	81	Q6NXT1
AEGKCPRQRRALERG	C4B	1591	P0C0L5
PERREKLCRANSRDG	ARHGEF2	771	Q92974
GPSSRNRRDGFCRKR	DEPDC4	36	Q8N2C3
EPSFLKECRRRGDNL	GSDMC	141	Q9BYG8
LPARRNRRAFGDKQS	ABCA1	1266	O95477
NRRAFGDKQSCLRPF	ABCA1	1271	O95477
CLAQNKRDFLRPGVR	ACOT6	121	Q3I5F7
LNFVRRPDDGALRKR	C1QTNF12	76	Q5T7M4
EPRLQFRAVCARGRG	ACTR5	56	Q9H9F9
RKGCLRFQLPERGSR	DFFB	31	O76075
GNLPFRRICKRFGAD	DUS3L	316	Q96G46
IRRLVFPKAGRRAAC	CCM2L	16	Q9NUG4
FPSCNRNGKRRKLRL	CIRBP-AS1	91	Q8TBR5
RQNRGRKACDRPVAK	RPS19BP1	96	Q86WX3
RRCSAPKETFAQGRL	ATP10A	1316	O60312
RRAKSKNGGRCLRER	TFAP2E	261	Q6VUC0
VRFLRLAFRPCGNAN	AP4M1	421	O00189
TDCRRRPGKKFLQDR	EVA1A	61	Q9H8M9
RFLKENCRPDGRELG	EXOSC8	16	Q96B26
TVIRACRGRNDLKRP	GOPC	251	Q9HD26
LDGQPFLRCDRQKCR	MICA	51	Q29983
GRLARCIVRKDPRAF	ABCD1	116	P33897
RNSNLLARRRGIPEC	ARHGEF28	981	Q8N1W1
FRRGFQAAFRARLCP	NPFFR1	336	Q9GZQ6
AAAAAAAPRRKRRVL	NKX2-4	181	Q9H2Z4
RAAPGAEFAPNKRRR	NONO	456	Q15233
EARLGCAPRFQEFRR	METRN	261	Q9UJH8
RCGDRLKPLERRAAR	LATS1	886	O95835
AFRKRRPRGVPCFRT	FOXK2	346	Q01167
CIRKHFLGRRRRGQP	DIO3	66	P55073
ALRGRLLCDFRRAPF	EXOSC6	91	Q5RKV6
LLCDFRRAPFAGRRR	EXOSC6	96	Q5RKV6
NLVAVRRDFCGRPRF	HEMK1	316	Q9Y5R4
RCRPGFRLKDDGRTC	LRP1	2966	Q07954
NGAGPRCNLFRCRRL	FER1L4	1631	A9Z1Z3
LSKRRRNLLRNPCGE	FBXO2	116	Q9UK22
KQLRDLCPSRGRKRF	PDCD4	441	Q53EL6
ARRKRNPLGSRCQGA	FAM217B	56	Q9NTX9
RCPRAACQAKRGDQR	NOTCH3	1386	Q9UM47
DEFLVKNDPCRARGR	MACF1	3306	O94854
QRGLRARVRPLFCAL	LMAN1	6	P49257
RRKTLNFDGRLPACA	LINGO3	366	P0C6S8
FPAECRLRRLAGQAR	LONRF2	191	Q1L5Z9
RNARLRCPFRKGACE	NR1I2	71	O75469
KVIRADPQGCRRRHS	IRS1	1086	P35568
KCQAEARRLRARGFP	DQX1	366	Q8TE96
AAAKFLGFRQRCIPR	NLRC5	1096	Q86WI3
FLVKNDPCRARGRTN	MACF1	7181	Q9UPN3
RALKGRAARRCLAQE	SBF1	591	O95248
QPRKRRCDSFVTGRR	NUTM1	1111	Q86Y26
RISPFLCLKDRRDFR	IFNW1	46	P05000
KERDGLRCRGNRSPV	IL32	121	P24001
GKLCRARRAQGAQRL	GRID2IP	216	A4D2P6
RRSRLEGILRFCKGD	DMRTA1	341	Q5VZB9
RLNRLPGAAARCLRK	GPATCH2L	306	Q9NWQ4
RRRRSSKRAEAPQGC	KLHDC7A	81	Q5VTJ3
GLRNVFATLNRCPKR	ERMARD	301	Q5T6L9
RCKPSFRESGSRNVR	DGKZ	151	Q13574
NGRTRGRFQRPLCRA	CELSR3	2916	Q9NYQ7
GRFQRPLCRAAQSER	CELSR3	2921	Q9NYQ7
LCDKQPIGRRLFRQF	GRK4	56	P32298
RVEFIDRPRCCLRGK	BTBD2	356	Q9BX70
AEGKCPRQRRALERG	C4A	1591	P0C0L4
LCAFDAARGPRRLMR	KRTCAP3	6	Q53RY4
EGSFRRRPRGFRRKC	FOXF2	186	Q12947
SFRRRPRGFRRKCQA	FOXF1	136	Q12946
KGLRERRHQCQAREP	LRRC56	336	Q8IYG6
DILDPNKFNSRRRRC	NKX1-1	86	Q15270
NKFNSRRRRCVLLGP	NKX1-1	91	Q15270
QNKARREDFCPRKLR	SMG9	371	Q9H0W8
LRAAAFRLARRQVPC	MRPL12	16	P52815
VNRKRPAREDCRGLT	ABCC8	646	Q09428
RRFRGQADCRQALPL	CIAO3	171	Q9H6Q4
KGASCIARPFRRDSQ	CLCA3P	201	Q9Y6N3
CRAQVDRFPAARFKK	RNASEH1	46	O60930
ARCLQSLARPGARDR	SEPTIN1	296	Q8WYJ6
GARCSSPRRLANKRI	SLIT3	461	O75094
FRKFDERCQPRSFLR	TIMELESS	486	Q9UNS1
DALQGRKCLRPRSRR	ZNF671	11	Q8TAW3
RRKRTPRGDKNFECH	ZNF157	151	P51786
PQCGKRFVRRASLAR	ZSCAN10	526	Q96SZ4
VLGFRDRLKPCRARQ	RIPOR3	541	Q96MK2
GDPRGRAARRDRFKQ	SOWAHA	46	Q2M3V2
CLARPEARRGNVKDA	TTI2	36	Q6NXR4
PRDFVSVRCAKRRGS	STAR	181	P49675
PKRSLFFNRDDRGRC	SLC19A1	206	P41440
KRCQLPDGSFRRQRK	SNRNP200	426	O75643
RECGRRFRQKPNLFR	ZNF875	556	P10072
DFGELRPRRRSRKCG	TRANK1	2906	O15050
SRRQKQLCRREPGLA	WNT9B	61	O14905
LVLDCRFAPKRRRRG	MST1R	296	Q04912
LRCPSGNVLRRRFLK	UBXN8	196	O00124
NLRRNPRCDVVERFG	ZNF44	106	P15621
KRARRCDAGGPRQLE	THUMPD1	26	Q9NXG2
PDCGRRFRQRGSLAI	ZNF785	231	A8K8V0
RARFPQRLGRAPCFE	UNQ6190/PRO20217	31	Q6UXQ8
QRLGRAPCFEVGLRK	UNQ6190/PRO20217	36	Q6UXQ8
RALFKRNPCNRLGAG	RPS6KA2	291	Q15349
CRRPEDAVAPRKRAR	LIME1	31	Q9H400
DGRFREQKFRLKRCG	MUS81	346	Q96NY9