Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	channel regulator activity	NEDD4L SLC15A1 KCNIP4 GNB2 KCNIP2	3.40e-04	174	69	5	GO:0016247
GeneOntologyMolecularFunction	transporter regulator activity	NEDD4L SLC15A1 KCNIP4 GNB2 KCNIP2	3.67e-04	177	69	5	GO:0141108
GeneOntologyMolecularFunction	lipopolysaccharide binding	ADGRB1 LTF DMBT1	6.11e-04	48	69	3	GO:0001530
GeneOntologyMolecularFunction	structural constituent of myelin sheath	MALL PLP1	6.34e-04	11	69	2	GO:0019911
GeneOntologyMolecularFunction	endopeptidase activity	RCE1 ADAMTS18 LTF MMP3 MMP10 BACE2 MASP2	6.99e-04	430	69	7	GO:0004175
GeneOntologyMolecularFunction	intramembrane lipid transporter activity	ANO7 ATP9A ATP10D	7.30e-04	51	69	3	GO:0140303
GeneOntologyMolecularFunction	serine-type peptidase activity	SCPEP1 LTF MMP3 MMP10 MASP2	7.48e-04	207	69	5	GO:0008236
GeneOntologyMolecularFunction	metalloendopeptidase activity	RCE1 ADAMTS18 MMP3 MMP10	7.93e-04	120	69	4	GO:0004222
GeneOntologyMolecularFunction	serine hydrolase activity	SCPEP1 LTF MMP3 MMP10 MASP2	8.33e-04	212	69	5	GO:0017171
GeneOntologyMolecularFunction	potassium channel regulator activity	NEDD4L KCNIP4 KCNIP2	1.01e-03	57	69	3	GO:0015459
GeneOntologyMolecularFunction	quaternary ammonium group transmembrane transporter activity	SLC16A9 SLC22A15	1.20e-03	15	69	2	GO:0015651
GeneOntologyMolecularFunction	transporter activity	CACNA1C SLC16A9 SLC15A1 SLC22A15 ANO7 KCNIP4 SLC12A8 SEC63 ATP9A KCNIP2 ITGAV ATP10D	1.42e-03	1289	69	12	GO:0005215
GeneOntologyBiologicalProcess	positive regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	3.30e-05	3	69	2	GO:0002879
GeneOntologyBiologicalProcess	hormone metabolic process	PNLIP FFAR3 GPR42 UGT2B10 SCPEP1 BACE2 ADH4	4.74e-05	286	69	7	GO:0042445
GeneOntologyBiologicalProcess	regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	6.59e-05	4	69	2	GO:0002877
GeneOntologyBiologicalProcess	regulation of hormone levels	CACNA1C PNLIP FFAR3 GPR42 UGT2B10 SCPEP1 BACE2 GDF9 ADCY8 ADH4	8.76e-05	684	69	10	GO:0010817
GeneOntologyBiologicalProcess	negative regulation of blood pressure	NEDD4L FFAR3 GPR42 SCPEP1	8.90e-05	70	69	4	GO:0045776
GeneOntologyBiologicalProcess	acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	1.10e-04	5	69	2	GO:0002525
GeneOntologyBiologicalProcess	monoatomic ion transport	CACNA1C NEDD4L SLC15A1 SLC22A15 ANO7 CP KCNIP4 SLC12A8 LTF GNB2 KCNIP2 ITGAV PLP1 ATP10D	1.54e-04	1374	69	14	GO:0006811
GeneOntologyBiologicalProcess	positive regulation of neuronal action potential	FFAR3 GPR42	1.64e-04	6	69	2	GO:1904457
GeneOntologyCellularComponent	integrin alphav-beta3 complex	ITGAV PLP1	3.31e-05	3	70	2	GO:0034683
GeneOntologyCellularComponent	integrin complex	ITGAL ITGAV PLP1	1.66e-04	32	70	3	GO:0008305
GeneOntologyCellularComponent	plasma membrane protein complex	CACNA1C TLR1 KCNIP4 GNB4 OLFM2 GNB2 KCNIP2 ITGAL ITGAV PLP1	2.72e-04	785	70	10	GO:0098797
MousePheno	abnormal sympathetic neuron innervation pattern	FFAR3 GPR42	5.42e-05	3	60	2	MP:0009284
MousePheno	abnormal circulating noradrenaline level	BRAF FFAR3 GPR42	6.94e-05	19	60	3	MP:0005663
MousePheno	abnormal digestion	PNLIP SLC15A1 FFAR3 GPR42 TM6SF2	8.55e-05	105	60	5	MP:0001664
MousePheno	abnormal sympathetic neuron physiology	FFAR3 GPR42	1.08e-04	4	60	2	MP:0009253
Domain	GPR40-rel_orph	FFAR3 GPR42	8.27e-05	4	70	2	IPR013312
Domain	EXPERA	TM6SF2 TM6SF1	1.37e-04	5	70	2	IPR033118
Domain	Guanine_nucleotide-bd_bsu	GNB4 GNB2	1.37e-04	5	70	2	IPR016346
Domain	EXPERA	TM6SF2 TM6SF1	1.37e-04	5	70	2	PS51751
Domain	CYSTEINE_SWITCH	ADAMTS18 MMP3 MMP10	4.85e-04	41	70	3	PS00546
Domain	Pept_M10_metallopeptidase	ADAMTS18 MMP3 MMP10	5.59e-04	43	70	3	IPR001818
Domain	Gprotein_B	GNB4 GNB2	6.11e-04	10	70	2	IPR001632
Domain	Integrin_alpha	ITGAL ITGAV	7.45e-04	11	70	2	PF00357
Domain	Recoverin	KCNIP4 KCNIP2	1.05e-03	13	70	2	IPR028846
Domain	P_typ_ATPase_c	ATP9A ATP10D	1.22e-03	14	70	2	IPR032630
Domain	P-type_ATPase_N	ATP9A ATP10D	1.22e-03	14	70	2	IPR032631
Domain	P-type_ATPase_IV	ATP9A ATP10D	1.22e-03	14	70	2	IPR006539
Domain	PhoLip_ATPase_C	ATP9A ATP10D	1.22e-03	14	70	2	PF16212
Domain	PhoLip_ATPase_N	ATP9A ATP10D	1.22e-03	14	70	2	PF16209
Domain	Pept_M10A_Zn_BS	MMP3 MMP10	1.41e-03	15	70	2	IPR021158
Domain	Integrin_alpha_C_CS	ITGAL ITGAV	1.61e-03	16	70	2	IPR018184
Domain	TSP_1	ADGRB1 ADAMTS18 SEMA5A	1.70e-03	63	70	3	PF00090
Domain	Hemopexin_CS	MMP3 MMP10	1.82e-03	17	70	2	IPR018486
Domain	TSP1	ADGRB1 ADAMTS18 SEMA5A	1.86e-03	65	70	3	SM00209
Domain	TSP1_rpt	ADGRB1 ADAMTS18 SEMA5A	1.86e-03	65	70	3	IPR000884
Domain	TSP1	ADGRB1 ADAMTS18 SEMA5A	1.86e-03	65	70	3	PS50092
Domain	Integrin_alpha-2	ITGAL ITGAV	2.04e-03	18	70	2	IPR013649
Domain	Integrin_alpha2	ITGAL ITGAV	2.04e-03	18	70	2	PF08441
Domain	Integrin_alpha	ITGAL ITGAV	2.04e-03	18	70	2	IPR000413
Domain	Pept_M10A_stromelysin-type	MMP3 MMP10	2.04e-03	18	70	2	IPR016293
Domain	INTEGRIN_ALPHA	ITGAL ITGAV	2.04e-03	18	70	2	PS00242
Domain	Int_alpha_beta-p	ITGAL ITGAV	2.27e-03	19	70	2	IPR013519
Domain	Int_alpha	ITGAL ITGAV	2.27e-03	19	70	2	SM00191
Domain	PG_binding_1	MMP3 MMP10	2.52e-03	20	70	2	PF01471
Domain	Peptidoglycan-bd-like	MMP3 MMP10	2.52e-03	20	70	2	IPR002477
Domain	FG_GAP	ITGAL ITGAV	3.05e-03	22	70	2	PS51470
Domain	Cupredoxin	CP PKHD1L1	3.05e-03	22	70	2	IPR008972
Domain	Hemopexin-like_dom	MMP3 MMP10	3.33e-03	23	70	2	IPR000585
Domain	Hemopexin-like_repeat	MMP3 MMP10	3.33e-03	23	70	2	IPR018487
Domain	M10A_MMP	MMP3 MMP10	3.33e-03	23	70	2	IPR033739
Domain	Hemopexin	MMP3 MMP10	3.33e-03	23	70	2	PF00045
Domain	HEMOPEXIN	MMP3 MMP10	3.33e-03	23	70	2	PS00024
Domain	-	MMP3 MMP10	3.33e-03	23	70	2	2.110.10.10
Domain	HEMOPEXIN_2	MMP3 MMP10	3.33e-03	23	70	2	PS51642
Domain	HX	MMP3 MMP10	3.33e-03	23	70	2	SM00120
Domain	Pept_M10A	MMP3 MMP10	3.33e-03	23	70	2	IPR021190
Domain	MetalloPept_cat_dom	ADAMTS18 MMP3 MMP10	3.49e-03	81	70	3	IPR024079
Domain	-	ADAMTS18 MMP3 MMP10	3.49e-03	81	70	3	3.40.390.10
Domain	FG-GAP	ITGAL ITGAV	3.62e-03	24	70	2	PF01839
Domain	FG-GAP	ITGAL ITGAV	3.62e-03	24	70	2	IPR013517
Domain	Peptidase_M10	MMP3 MMP10	3.62e-03	24	70	2	PF00413
Domain	Integrin_dom	ITGAL ITGAV	3.93e-03	25	70	2	IPR032695
Domain	ZnMc	MMP3 MMP10	5.27e-03	29	70	2	SM00235
Domain	Peptidase_Metallo	MMP3 MMP10	5.27e-03	29	70	2	IPR006026
Domain	ZINC_PROTEASE	ADAMTS18 MMP3 MMP10	5.95e-03	98	70	3	PS00142
Domain	TIG	RBPJL PKHD1L1	6.00e-03	31	70	2	PF01833
Domain	IPT	RBPJL PKHD1L1	6.39e-03	32	70	2	IPR002909
Domain	-	ATP9A ATP10D	6.39e-03	32	70	2	3.40.1110.10
Domain	-	ATP9A ATP10D	6.39e-03	32	70	2	2.70.150.10
Domain	Ig_E-set	RBPJL SEC63 PKHD1L1	7.01e-03	104	70	3	IPR014756
Domain	EF-hand_8	KCNIP4 KCNIP2	7.19e-03	34	70	2	PF13833
Pathway	REACTOME_ADRENALINE_NORADRENALINE_INHIBITS_INSULIN_SECRETION	CACNA1C GNB4 GNB2	1.54e-04	28	53	3	M10679
Pathway	REACTOME_REGULATION_OF_INSULIN_SECRETION	CACNA1C GNB4 GNB2 ADCY8	2.07e-04	78	53	4	M1921
Pathway	REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS	GNB4 GNB2 ADCY8	2.53e-04	33	53	3	MM15058
Pathway	REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION	GNB4 GNB2 ADCY8	2.53e-04	33	53	3	M11575
Pathway	REACTOME_PHASE_1_INACTIVATION_OF_FAST_NA_CHANNELS	KCNIP4 KCNIP2	2.88e-04	7	53	2	M27457
Pathway	REACTOME_PHASE_1_INACTIVATION_OF_FAST_NA_CHANNELS	KCNIP4 KCNIP2	2.88e-04	7	53	2	MM15199
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	NEDD4L SLC15A1 SLC22A15 ANO7 CP GNB4 GNB2 ATP9A ADCY8 ATP10D	3.58e-04	736	53	10	M27287
Pathway	REACTOME_GLUCAGON_LIKE_PEPTIDE_1_GLP1_REGULATES_INSULIN_SECRETION	GNB4 GNB2 ADCY8	5.19e-04	42	53	3	M791
Pathway	REACTOME_ADORA2B_MEDIATED_ANTI_INFLAMMATORY_CYTOKINES_PRODUCTION	GNB4 GNB2 ADCY8	5.57e-04	43	53	3	M29837
Pathway	REACTOME_VASOPRESSIN_REGULATES_RENAL_WATER_HOMEOSTASIS_VIA_AQUAPORINS	GNB4 GNB2 ADCY8	5.57e-04	43	53	3	M933
Pathway	REACTOME_GABA_B_RECEPTOR_ACTIVATION	GNB4 GNB2 ADCY8	5.57e-04	43	53	3	M954
Pathway	REACTOME_GABA_B_RECEPTOR_ACTIVATION	GNB4 GNB2 ADCY8	5.96e-04	44	53	3	MM15709
Pathway	REACTOME_GPER1_SIGNALING	GNB4 GNB2 ADCY8	6.37e-04	45	53	3	M45008
Pathway	REACTOME_INTEGRATION_OF_ENERGY_METABOLISM	CACNA1C GNB4 GNB2 ADCY8	7.15e-04	108	53	4	M17034
Pathway	REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS	GNB4 GNB2 ADCY8	7.70e-04	48	53	3	M10775
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	NEDD4L SLC15A1 SLC22A15 ANO7 CP GNB4 GNB2 ATP9A ATP10D	8.92e-04	681	53	9	MM14985
Pathway	REACTOME_AQUAPORIN_MEDIATED_TRANSPORT	GNB4 GNB2 ADCY8	9.74e-04	52	53	3	M920
Pubmed	Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.	FFAR3 GPR42	3.99e-06	2	70	2	25637492
Pubmed	Selective tracking of FFAR3-expressing neurons supports receptor coupling to N-type calcium channels in mouse sympathetic neurons.	FFAR3 GPR42	3.99e-06	2	70	2	30478340
Pubmed	3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41.	FFAR3 GPR42	3.99e-06	2	70	2	38040866
Pubmed	Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APPswe Alzheimer's Disease Mouse Model.	FFAR3 GPR42	3.99e-06	2	70	2	35408893
Pubmed	FFAR3 modulates insulin secretion and global gene expression in mouse islets.	FFAR3 GPR42	3.99e-06	2	70	2	26091414
Pubmed	GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states.	FFAR3 GPR42	3.99e-06	2	70	2	27550964
Pubmed	Intestinal FFA3 mediates obesogenic effects in mice on a Western diet.	FFAR3 GPR42	3.99e-06	2	70	2	35858247
Pubmed	Higher Content but Not Activity of Stromelysin-2 (MMP-10) in Comparison to Stromelysin-1 (MMP-3) in Human Renal Carcinoma.	MMP3 MMP10	3.99e-06	2	70	2	36231910
Pubmed	Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.	FFAR3 GPR42	3.99e-06	2	70	2	22506074
Pubmed	Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress.	FFAR3 GPR42	3.99e-06	2	70	2	32073900
Pubmed	Expression of matrix metalloproteinase-3 and -10 is up-regulated in the periodontal tissues of aged mice.	MMP3 MMP10	3.99e-06	2	70	2	35502585
Pubmed	Effects of metal-binding properties of human Kv channel-interacting proteins on their molecular structure and binding with Kv4.2 channel.	KCNIP4 KCNIP2	3.99e-06	2	70	2	16951992
Pubmed	The effects of propionate and valerate on insulin responsiveness for glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes via G protein-coupled receptor 41.	FFAR3 GPR42	3.99e-06	2	70	2	24748202
Pubmed	Structural characterization of the ceruloplasmin: lactoferrin complex in solution.	CP LTF	3.99e-06	2	70	2	17597152
Pubmed	The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity.	FFAR3 GPR42	3.99e-06	2	70	2	36362376
Pubmed	Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts.	MMP3 MMP10	3.99e-06	2	70	2	2605216
Pubmed	Cloning of the novel gene TM6SF1 reveals conservation of clusters of paralogous genes between human chromosomes 15q24-->q26 and 19p13.3-->p12.	TM6SF2 TM6SF1	3.99e-06	2	70	2	11124529
Pubmed	The role of DNA hypomethylation in the control of stromelysin gene expression.	MMP3 MMP10	3.99e-06	2	70	2	16516860
Pubmed	Studies of the ceruloplasmin-lactoferrin complex.	CP LTF	3.99e-06	2	70	2	11908641
Pubmed	Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.	FFAR3 GPR42	3.99e-06	2	70	2	20399779
Pubmed	Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42.	FFAR3 GPR42	3.99e-06	2	70	2	19630535
Pubmed	Interaction of lactoferrin with ceruloplasmin.	CP LTF	3.99e-06	2	70	2	10666301
Pubmed	Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content.	FFAR3 GPR42	3.99e-06	2	70	2	23110765
Pubmed	Ceruloplasmin Reduces the Lactoferrin/Oleic Acid Antitumor Complex-Mediated Release of Heme-Containing Proteins from Blood Cells.	CP LTF	3.99e-06	2	70	2	38069040
Pubmed	The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation.	FFAR3 GPR42	3.99e-06	2	70	2	26522986
Pubmed	Antioxidant and antibacterial genes are upregulated in early involution of the mouse mammary gland: sharp increase of ceruloplasmin and lactoferrin in accumulating breast milk.	CP LTF	3.99e-06	2	70	2	16989572
Pubmed	Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.	FFAR3 GPR42	3.99e-06	2	70	2	14722361
Pubmed	Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41.	FFAR3 GPR42	3.99e-06	2	70	2	27664183
Pubmed	Transcriptional and electrophysiological consequences of KChIP2-mediated regulation of CaV1.2.	CACNA1C KCNIP2	3.99e-06	2	70	2	19713767
Pubmed	Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.	FFAR3 GPR42	3.99e-06	2	70	2	26260360
Pubmed	G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation.	FFAR3 GPR42	3.99e-06	2	70	2	37019194
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	NEDD4L CP SEMA5A SCPEP1 PBLD GNB4 FUCA1 LTF GNB2 ITGAV MASP2	9.13e-06	1070	70	11	23533145
Pubmed	Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation.	FFAR3 GPR42	1.20e-05	3	70	2	22673524
Pubmed	Multiple Kv channel-interacting proteins contain an N-terminal transmembrane domain that regulates Kv4 channel trafficking and gating.	KCNIP4 KCNIP2	1.20e-05	3	70	2	18957440
Pubmed	Study of interaction of ceruloplasmin, lactoferrin, and myeloperoxidase by photon correlation spectroscopy.	CP LTF	1.20e-05	3	70	2	19916937
Pubmed	The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.	FFAR3 GPR42	1.20e-05	3	70	2	12496283
Pubmed	Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.	FFAR3 GPR42	1.20e-05	3	70	2	23665276
Pubmed	Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer.	FFAR3 GPR42	1.20e-05	3	70	2	34210970
Pubmed	Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3.	FFAR3 GPR42	1.20e-05	3	70	2	31719611
Pubmed	Up-regulation of matrix metalloproteinases in a mouse model of chemically induced colitis-associated cancer: the role of microRNAs.	MMP3 MMP10	1.20e-05	3	70	2	25742789
Pubmed	Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43.	FFAR3 GPR42	1.20e-05	3	70	2	16123168
Pubmed	Selective association of G protein beta(4) with gamma(5) and gamma(12) subunits in bovine tissues.	GNB4 GNB2	1.20e-05	3	70	2	10409705
Pubmed	GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.	FFAR3 GPR42	1.20e-05	3	70	2	22493486
Pubmed	Myelin Proteolipid Protein Complexes with αv Integrin and AMPA Receptors In Vivo and Regulates AMPA-Dependent Oligodendrocyte Progenitor Cell Migration through the Modulation of Cell-Surface GluR2 Expression.	ITGAV PLP1	1.20e-05	3	70	2	26311781
Pubmed	Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.	FFAR3 GPR42	1.20e-05	3	70	2	23066016
Pubmed	Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression.	MMP3 MMP10	1.20e-05	3	70	2	8175886
Pubmed	Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.	FFAR3 GPR42	1.20e-05	3	70	2	25581519
Pubmed	Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.	FFAR3 GPR42	1.20e-05	3	70	2	22190648
Pubmed	Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.	FFAR3 GPR42	1.20e-05	3	70	2	31272808
Pubmed	GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.	FFAR3 GPR42	1.20e-05	3	70	2	23885020
Pubmed	Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.	FFAR3 GPR42	1.20e-05	3	70	2	29768180
Pubmed	Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.	FFAR3 GPR42	1.20e-05	3	70	2	18931303
Pubmed	GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex virus type 1 infection.	FFAR3 GPR42	1.20e-05	3	70	2	38524121
Pubmed	Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function.	FFAR3 GPR42	1.20e-05	3	70	2	38329121
Pubmed	Correlations between ceruloplasmin, lactoferrin and myeloperoxidase in meconium.	CP LTF	1.20e-05	3	70	2	27903408
Pubmed	Differential distribution of KChIPs mRNAs in adult mouse brain.	KCNIP4 KCNIP2	2.39e-05	4	70	2	15363885
Pubmed	Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.	FFAR3 GPR42	2.39e-05	4	70	2	23401498
Pubmed	Structure, alternative splicing, and expression of the human and mouse KCNIP gene family.	KCNIP4 KCNIP2	2.39e-05	4	70	2	16112838
Pubmed	Matrix metalloproteinase genes on chromosome 11q22 and the risk of anterior cruciate ligament (ACL) rupture.	MMP3 MMP10	2.39e-05	4	70	2	21410539
Pubmed	A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.	FFAR3 GPR42	2.39e-05	4	70	2	9344866
Pubmed	Myelin proteolipid protein forms a complex with integrins and may participate in integrin receptor signaling in oligodendrocytes.	ITGAV PLP1	2.39e-05	4	70	2	12196561
Pubmed	Coordinate expression of matrix metalloproteinase family members in the uterus of normal, matrilysin-deficient, and stromelysin-1-deficient mice.	MMP3 MMP10	2.39e-05	4	70	2	9348221
Pubmed	Specific effects of KChIP3/calsenilin/DREAM, but not KChIPs 1, 2 and 4, on calcium signalling and regulated secretion in PC12 cells.	KCNIP4 KCNIP2	2.39e-05	4	70	2	18393943
Pubmed	Expression of Matrix Metalloproteinases and Their Inhibitors in Endometrium: High Levels in Endometriotic Lesions.	MMP3 MMP10	2.39e-05	4	70	2	32325785
Pubmed	Diversity among the beta subunits of heterotrimeric GTP-binding proteins: characterization of a novel beta-subunit cDNA.	GNB4 GNB2	2.39e-05	4	70	2	1543505
Pubmed	Genetic variations in matrix metalloproteinases may be associated with increased risk of ulcerative colitis.	MMP3 MMP10	2.39e-05	4	70	2	21925226
Pubmed	Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).	FFAR3 GPR42	2.39e-05	4	70	2	21518883
Pubmed	The role of G protein beta subunits in the release of ATP from human erythrocytes.	GNB4 GNB2	2.39e-05	4	70	2	12512701
Pubmed	A family of fatty acid binding receptors.	FFAR3 GPR42	2.39e-05	4	70	2	15684720
Pubmed	Age- and gender-dependent changes in connective tissue remodeling: physiological differences in circulating MMP-3, MMP-10, TIMP-1 and TIMP-2 level.	MMP3 MMP10	2.39e-05	4	70	2	20215736
Pubmed	Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice.	FFAR3 GPR42	2.39e-05	4	70	2	29021375
Pubmed	Microbial metabolites, short-chain fatty acids, restrain tissue bacterial load, chronic inflammation, and associated cancer in the colon of mice.	FFAR3 GPR42	2.39e-05	4	70	2	29644622
Pubmed	Glucagon and regulation of glucose metabolism.	GNB4 GNB2 ADCY8	3.37e-05	31	70	3	12626323
Pubmed	Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease.	MMP3 MMP10	3.98e-05	5	70	2	18035073
Pubmed	Expression of interstitial collagenase during skeletal development of the mouse is restricted to osteoblast-like cells and hypertrophic chondrocytes.	MMP3 MMP10	3.98e-05	5	70	2	7669731
Pubmed	Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins.	KCNIP4 KCNIP2	3.98e-05	5	70	2	15184042
Pubmed	Fatty acid binding receptors and their physiological role in type 2 diabetes.	FFAR3 GPR42	3.98e-05	5	70	2	19009545
Pubmed	Immunohistochemical and transcriptional expression of matrix metalloproteinases in full-term human umbilical cord and human umbilical vein endothelial cells.	MMP3 MMP10	3.98e-05	5	70	2	20936527
Pubmed	Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.	FFAR3 GPR42	3.98e-05	5	70	2	24327954
Pubmed	Nitric oxide-mediated invasion in Barrett's high-grade dysplasia and adenocarcinoma.	MMP3 MMP10	3.98e-05	5	70	2	20584750
Pubmed	Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81.	FFAR3 GPR42	3.98e-05	5	70	2	19047060
Pubmed	Integrins take partners: cross-talk between integrins and other membrane receptors.	ITGAL ITGAV	5.96e-05	6	70	2	9789327
Pubmed	Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein.	MMP3 MMP10	5.96e-05	6	70	2	7694569
Pubmed	Gialpha and Gbeta subunits both define selectivity of G protein activation by alpha2-adrenergic receptors.	GNB4 GNB2	5.96e-05	6	70	2	16371464
Pubmed	Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons.	KCNIP4 KCNIP2	5.96e-05	6	70	2	20943905
Pubmed	Identification of Gnr1p, a negative regulator of G alpha signalling in Schizosaccharomyces pombe, and its complementation by human G beta subunits.	GNB4 GNB2	5.96e-05	6	70	2	16884933
Pubmed	Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein.	MMP3 MMP10	5.96e-05	6	70	2	8144618
Pubmed	Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis.	FFAR3 GPR42	5.96e-05	6	70	2	19460454
Pubmed	Matrix metalloproteinases regulate mesonephric cell migration in developing XY gonads which correlates with the inhibition of tissue inhibitor of metalloproteinase-3 by Sry.	MMP3 MMP10	5.96e-05	6	70	2	11869290
Pubmed	Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction.	SEL1L3 CP MMP3 MMP10	6.17e-05	105	70	4	24667918
Pubmed	Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3.	MMP3 MMP10	8.33e-05	7	70	2	8921407
Pubmed	ETS-1 converts endothelial cells to the angiogenic phenotype by inducing the expression of matrix metalloproteinases and integrin beta3.	MMP3 ITGAV	8.33e-05	7	70	2	10048576
Pubmed	Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation.	MMP3 MMP10	8.33e-05	7	70	2	11113146
Pubmed	Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells.	ITGAL ITGAV	8.33e-05	7	70	2	15284116
Pubmed	Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.	FFAR3 GPR42	1.11e-04	8	70	2	34626852
Pubmed	Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2.	MMP3 MMP10	1.11e-04	8	70	2	11865039
Pubmed	The gene for the beta-subunit of retinal transducin (Gnb-1) maps to distal mouse chromosome 4, and related sequences map to mouse chromosomes 5 and 8.	GNB4 GNB2	1.11e-04	8	70	2	2328987
Pubmed	Proteomic analyses of native brain K(V)4.2 channel complexes.	KCNIP4 KCNIP2	1.11e-04	8	70	2	19713751
Pubmed	The L1 adhesion molecule is a cellular ligand for VLA-5.	ITGAL ITGAV	1.42e-04	9	70	2	8557754
Pubmed	Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.	GNB4 GNB2	1.42e-04	9	70	2	10339615
Cytoband	4p12	YIPF7 ATP10D	4.28e-04	20	70	2	4p12
Cytoband	Ensembl 112 genes in cytogenetic band chr11q22	DYNC2H1 MMP3 MMP10	6.01e-04	107	70	3	chr11q22
Cytoband	Ensembl 112 genes in cytogenetic band chr4p12	YIPF7 ATP10D	7.27e-04	26	70	2	chr4p12
Cytoband	Ensembl 112 genes in cytogenetic band chr8p21	EXTL3 ELP3 BIN3	1.18e-03	135	70	3	chr8p21
Cytoband	Ensembl 112 genes in cytogenetic band chr4q23	DAPP1 ADH4	1.47e-03	37	70	2	chr4q23
Cytoband	11q22.3	MMP3 MMP10	2.08e-03	44	70	2	11q22.3
Cytoband	19q13.1	FFAR3 GPR42	3.23e-03	55	70	2	19q13.1
GeneFamily	Potassium voltage-gated channel regulatory subunits\|DASH family	KCNIP4 KCNIP2	7.39e-04	15	49	2	858
GeneFamily	ATPase phospholipid transporting	ATP9A ATP10D	7.39e-04	15	49	2	1210
GeneFamily	CD molecules\|Integrin alpha subunits	ITGAL ITGAV	1.07e-03	18	49	2	1160
GeneFamily	Endogenous ligands\|Matrix metallopeptidases	MMP3 MMP10	1.91e-03	24	49	2	891
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	C2CD3 NEDD4L	4.27e-03	36	49	2	823
Coexpression	DESCARTES_FETAL_PLACENTA_SMOOTH_MUSCLE_CELLS	CACNA1C ADGRB1 PAQR5 ADAMTS18 OLFM2	4.10e-06	89	70	5	M40280
Coexpression	GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_MONOCYTE_DN	CACNA1C BRAF FFAR3 SEL1L3 DAPP1 GDF9	1.55e-05	199	70	6	M4997
Coexpression	HALLMARK_COMPLEMENT	RCE1 CP GNB4 LTF GNB2 KCNIP2	1.60e-05	200	70	6	M5921
Coexpression	MIKKELSEN_MEF_ICP_WITH_H3K27ME3	MALL FFAR3 GPR42 ENTPD3 KCNIP2 PKHD1L1	2.95e-05	223	70	6	MM838
Coexpression	ONDER_CDH1_TARGETS_2_DN	CDS1 MALL SEL1L3 DAPP1 XDH SLC12A8 MMP10 BACE2	3.76e-05	473	70	8	M4306
CoexpressionAtlas	DevelopingLowerUrinaryTract_adult_ureter_emap-29479_top-relative-expression-ranked_1000	CDS1 NEDD4L MALL ENTPD3 SLC22A15 SEL1L3 DAPP1 PAQR5 UGT2B10 XDH CP LTF BACE2	6.05e-07	736	69	13	gudmap_developingLowerUrinaryTract_adult_ureter_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_adult_ureter_emap-29479_top-relative-expression-ranked_500	CDS1 MALL ENTPD3 PAQR5 UGT2B10 CP LTF BACE2	2.76e-05	373	69	8	gudmap_developingLowerUrinaryTract_adult_ureter_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_adult_ureter_emap-29479_k-means-cluster#2_top-relative-expression-ranked_1000	NEDD4L MALL SLC22A15 SEL1L3 DAPP1 CP BACE2	3.86e-05	285	69	7	gudmap_developingLowerUrinaryTract_adult_ureter_1000_k2
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_secretory-Secretory_Club\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	NEDD4L MALL RBPJL SEL1L3 XDH CP LTF	2.45e-08	195	70	7	b9e8f405f6d837bb39b615836d3e2df349737c0e
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	C1QL1 ADGRB1 PCDHAC1 SEMA5A OLFM2 KCNIP2	1.66e-07	155	70	6	77fdae85d36efb776db977eb424b32487ef222e4
ToppCell	Biopsy_Control_(H.)-Epithelial-SCGB3A2+_SCGB1A1+\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	NEDD4L SEL1L3 XDH CP LTF BACE2	6.98e-07	198	70	6	a3d4b6e4259ded2193d94d2ff6d48cf67214fc35
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_secretory\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	NEDD4L MALL SEL1L3 XDH CP LTF	7.19e-07	199	70	6	a8bfc0b93ad9968cf52a25be86995ffe436bd636
ToppCell	Biopsy_IPF-Epithelial-SCGB3A2+_SCGB1A1+\|Biopsy_IPF / Sample group, Lineage and Cell type	NEDD4L MALL SEL1L3 CP LTF BACE2	7.19e-07	199	70	6	c6150f5fe2ce4466149a4d553acb907034a72efb
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLC16A9 ENTPD3 SEL1L3 CP SLC12A8 BACE2	7.41e-07	200	70	6	c450a15e21fa72d071ed6e3b9f22de557a0f3cea
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SLC16A9 ENTPD3 CP SLC12A8 EXTL3 BACE2	7.41e-07	200	70	6	ed093626a9cac7531a2bf02f6e345c5e84b8c060
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDS1 SLC15A1 MALL XDH PBLD DMBT1	7.41e-07	200	70	6	0ca955b71b97571b45e9e89004f1d0bb9fc9e67b
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)\|Thalamus / BrainAtlas - Mouse McCarroll V32	C1QL1 PNLIP RBPJL OLFM2 GDF9	7.76e-07	108	70	5	63d45cc3ee149a7baf255b70409f8ea54c56157b
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P3-Tnr\|Thalamus / BrainAtlas - Mouse McCarroll V32	C1QL1 PNLIP RBPJL OLFM2 GDF9	7.76e-07	108	70	5	d57eeda825b6e0e64bae185896ae7eea6a2a50e9
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	C1QL1 PNLIP RBPJL OLFM2 GDF9	7.76e-07	108	70	5	c2aa6bf8554bfb6b0f9c5f6658601c6cf7c8bdbc
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P3\|Thalamus / BrainAtlas - Mouse McCarroll V32	C1QL1 PNLIP RBPJL OLFM2 GDF9	7.76e-07	108	70	5	db8472616886c6195f8c27c00f00133a9c10691d
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC22A15 CP LTF ITGAL ITGAV	4.18e-06	152	70	5	82a493ffb2f1704cd6f68a82d970fe12f537d20e
ToppCell	Goblet\|World / Class top	SEL1L3 SLC12A8 LTF DMBT1 BACE2	4.89e-06	157	70	5	b352aa37d662629db6a9c6def9ee6d7c49a9071c
ToppCell	Goblet-gob-1\|World / Class top	SEL1L3 SLC12A8 LTF DMBT1 BACE2	5.20e-06	159	70	5	62d4ca2b538382419252e306d7a789b64420fb18
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC16A9 SEL1L3 CP LTF BACE2	6.61e-06	167	70	5	31633899aae852873a4887e72c621474b0a51a33
ToppCell	facs-Aorta-Heart-3m-Endothelial-endocardial_endothelial_cells\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MALL PAQR5 BACE2 TM6SF2 PKHD1L1	6.61e-06	167	70	5	a4a795751644b22af616335379e64ae95175180c
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDS1 SLC16A9 TM6SF1 ITGAL PLP1	7.00e-06	169	70	5	aec1b4c7e973a31c53aaea47c2c05d24ce16aa4f
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDS1 SLC16A9 ADGRB1 DMBT1 ITGAL	7.20e-06	170	70	5	a121e10099faaeb60251eec162f38caf7c4238c2
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NEDD4L SLC15A1 MALL SEL1L3 CP	7.41e-06	171	70	5	fd59ac4a39748840b2ee1c930ea475433ff61485
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NEDD4L SLC15A1 MALL SEL1L3 CP	7.41e-06	171	70	5	d5960b40ad5b87aaa00c93a6b31cdf41cc4f1375
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-epithelial_cell_of_lung\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NEDD4L SLC15A1 MALL SEL1L3 CP	7.41e-06	171	70	5	d382430e5cdd0f2aac4fc093d8fe8d66efb4629b
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NEDD4L SLC15A1 MALL SEL1L3 CP	7.41e-06	171	70	5	4347e6f62c04ea43299893ad4b79719049009a56
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC16A9 SEL1L3 CP LTF BACE2	7.84e-06	173	70	5	3aa1d28d4814798a772808ed29e1dbbdf92abd03
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC16A9 SEL1L3 CP LTF BACE2	7.84e-06	173	70	5	e8afef5ae68983eb8d6515b43952636a47e9d3d4
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC16A9 DHX37 CP MMP3 MMP10	8.07e-06	174	70	5	3f0a5ce074675d57d479fa069385a1b3071e884e
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNLIP RBPJL CP SLC12A8 DMBT1	8.29e-06	175	70	5	3f1b2e23fec953148fb0711e523c463adb07dca4
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NEDD4L SLC16A9 DHX37 LTF ADCY8	8.29e-06	175	70	5	dbd9dac129fb6ae5f55e7b96d04b37585458dc4a
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDS1 SLC16A9 ADGRB1 DMBT1 ITGAL	8.29e-06	175	70	5	f7cd2ef79d91d64976fcdb5f1e7343b24ba27456
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CP SEMA5A MMP3 MMP10 BACE2	8.76e-06	177	70	5	cbad1a23851151dbef01ea2af960e6f0944f838b
ToppCell	nucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CP SEMA5A MMP3 MMP10 BACE2	8.76e-06	177	70	5	ce86dfaeb74d995a19aea62f0fb15c4c0bb854b0
ToppCell	facs-Pancreas-Exocrine-18m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNLIP RBPJL CP SLC12A8 DMBT1	9.25e-06	179	70	5	bbfbfb32773346080127055b5aafa36bbf7d0942
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Proximal_progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	XDH PBLD LTF DMBT1 KCNIP2	9.51e-06	180	70	5	8d9be9cfdf98e5888654a28ab12e5e89f201af00
ToppCell	facs-Pancreas-Exocrine\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNLIP RBPJL CP SEMA5A DMBT1	1.00e-05	182	70	5	45faefd7cbeac84d2c58650530b902af6ce921f8
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SLC16A9 SLC15A1 PAQR5 KCNIP4 LTF	1.00e-05	182	70	5	9d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MALL CP BACE2 TM6SF2 PKHD1L1	1.03e-05	183	70	5	6c4a09c02e30e1f24dde39f8cb8c5b453826ee2e
ToppCell	COPD-Epithelial-Basal\|COPD / Disease state, Lineage and Cell class	NEDD4L SEMA5A MMP3 MMP10 BACE2	1.03e-05	183	70	5	0f760e393edc91009bf6c7e02eeac039a1dfb4ed
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QL1 PNLIP SEMA5A OLFM2 TMEM255A	1.06e-05	184	70	5	278a7ed764c326450cb70e69ed2175980eaf5fe0
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C1QL1 PNLIP SEMA5A OLFM2 TMEM255A	1.06e-05	184	70	5	8d86e125257ff1d3af8d90577a8b3f0321eca21c
ToppCell	Control-Epithelial-Goblet\|World / Disease state, Lineage and Cell class	NEDD4L MALL CP LTF BACE2	1.09e-05	185	70	5	9a793e6016295a63820e9d7563f195494ac692e7
ToppCell	COPD-Epithelial-Goblet\|World / Disease state, Lineage and Cell class	NEDD4L MALL CP LTF BACE2	1.11e-05	186	70	5	d75fe7640a4b2c450c9759a1b3c3ef2a087f0092
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNLIP RBPJL CP SEMA5A DMBT1	1.14e-05	187	70	5	9aa411ae9b5a923378a5daebb8bb2fc2613f2510
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P3\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	C1QL1 PNLIP RBPJL LTF	1.19e-05	89	70	4	9e7041ab9409028007fefe53db6d1048eafae93b
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	C1QL1 PNLIP RBPJL LTF	1.19e-05	89	70	4	436e1229ee28517c11dfe0a5d1cdad3477419e00
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	C1QL1 PNLIP RBPJL LTF	1.19e-05	89	70	4	e7abf4af18d63c9384d25365a827e85a9adee964
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cspg5_(Cspg5)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	C1QL1 PNLIP RBPJL LTF	1.19e-05	89	70	4	4e5f4c0404968422703c248488e6b2ee8737dc00
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid-Mast_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FFAR3 GPR42 YIPF7 BACE2 TM6SF1	1.20e-05	189	70	5	7bc6e152fb4fe5cd6db9407929c15843a5d8f8c4
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MALL CP BACE2 TM6SF2 PKHD1L1	1.23e-05	190	70	5	6f71a9f74af7cd9a674753cfc9833ebe5bba0fa2
ToppCell	IPF-Epithelial-Goblet\|IPF / Disease state, Lineage and Cell class	NEDD4L MALL CP LTF BACE2	1.23e-05	190	70	5	e41dd5a997ad9952810ffecb57737c03ea1d88b3
ToppCell	IPF-Epithelial-Goblet\|World / Disease state, Lineage and Cell class	NEDD4L MALL CP LTF BACE2	1.23e-05	190	70	5	c29dabf0826663b9d6df51a7af9b76592090e44c
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CDS1 NEDD4L MALL SEL1L3 ADCY8	1.27e-05	191	70	5	34cc997e4e5c727495f321e6807a84aa124da486
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NEDD4L PAQR5 KCNIP4 ATP9A BACE2	1.30e-05	192	70	5	f7e7491426bbd6ed29a465b58bf67acb93dbb90a
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-B_atypical\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SEL1L3 DAPP1 SCPEP1 SLC12A8 BACE2	1.30e-05	192	70	5	24797e80b1f5b3ea5a0410caaf57ccf2ae9d716e
ToppCell	COPD-Epithelial-Goblet\|COPD / Disease state, Lineage and Cell class	NEDD4L MALL CP LTF BACE2	1.30e-05	192	70	5	93b2ca0a97776d28c7e8f1a0642c4b63a5554aab
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CDS1 NEDD4L MALL DMBT1 ADCY8	1.30e-05	192	70	5	fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD\|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	CFAP54 SLC15A1 CP KCNIP4 LTF	1.33e-05	193	70	5	ca7c0a4ceb05bced90f6cdc53d278e547fb241e9
ToppCell	facs-Pancreas-Exocrine-3m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNLIP XDH CP SEMA5A DMBT1	1.33e-05	193	70	5	c3161a14a40323a58aa202c8a1d6ea0e9c2b9814
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NEDD4L SEL1L3 CP LTF BACE2	1.36e-05	194	70	5	855d6acfcf323868ba98b213f06186ad4793d4ed
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NEDD4L SEL1L3 CP LTF BACE2	1.36e-05	194	70	5	dc531cf9089f2c956621d70d49a2b8219b4b45c1
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NEDD4L SEL1L3 CP LTF BACE2	1.36e-05	194	70	5	29a7770bdbea6081a9ed64a997cd92a1cbf4af58
ToppCell	cellseq-Epithelial-Epithelial_Glandular\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLC16A9 CP LTF DMBT1 BACE2	1.36e-05	194	70	5	d0fb1ff5cf0738881e114a58f0b27489f781d72b
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NEDD4L SEL1L3 CP LTF BACE2	1.36e-05	194	70	5	ca051088f880154ae2fd3f0ab3cef5a8dba8c371
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC16A9 SEL1L3 CP LTF BACE2	1.40e-05	195	70	5	2a9a36df1dbc4eac77a8ddbe939ec8a8d6c41464
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-club_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC16A9 SEL1L3 CP LTF BACE2	1.40e-05	195	70	5	460e12044905370797fd9774e99c3aedaebfe343
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC16A9 SEL1L3 CP LTF BACE2	1.40e-05	195	70	5	576142b4e75457c0973051bccc4163bd624496af
ToppCell	Bronchial-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Duct\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	SLC16A9 ENTPD3 CP LTF DMBT1	1.40e-05	195	70	5	fc2a1d84b3d013e5cb9e7b9cdd740e4010897d20
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC16A9 SEL1L3 CP LTF BACE2	1.40e-05	195	70	5	8f151066ad3ebd9661ea0b733f03c2ce1518f9ad
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC16A9 SEL1L3 CP LTF BACE2	1.40e-05	195	70	5	ff9f6b38f41dc5660b746fe40ceaddfb2958acd3
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC16A9 SEL1L3 CP LTF BACE2	1.43e-05	196	70	5	8e909c31733762646359fe78b645cbd60237459e
ToppCell	BAL-Mild-Epithelial-Epithelial-Basal/Club-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC16A9 MALL CP LTF MMP10	1.43e-05	196	70	5	a4d05d85fbafa869df19bba3881020ea433d81fb
ToppCell	BAL-Mild-Epithelial-Epithelial-Basal/Club-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SLC16A9 MALL CP LTF MMP10	1.43e-05	196	70	5	91a3c3091064f1f5a3bdc1dd5883fc24dce8ff05
ToppCell	BAL-Mild-Epithelial-Epithelial-Basal/Club\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC16A9 MALL CP LTF MMP10	1.43e-05	196	70	5	e819088a74d29e958371aa851ac9c74ec55367b7
ToppCell	BAL-Mild-Epithelial-Epithelial-Basal/Club\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SLC16A9 MALL CP LTF MMP10	1.43e-05	196	70	5	e675d661b6494ac3a85ba7ee5bdeaa98b8bbe957
ToppCell	AT2_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	MALL CP DMBT1 ATP9A BACE2	1.47e-05	197	70	5	5e0d222872a25bb9e9069d3dffda2844bb69874a
ToppCell	Mild_COVID-19-Epithelial-Basal/Club\|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）	SLC16A9 MALL CP LTF MMP10	1.47e-05	197	70	5	4cc5b778e1e2c6c149160fa147c172977c0fa8eb
ToppCell	5'-Adult-SmallIntestine-Epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC15A1 MALL PBLD DMBT1 TM6SF2	1.51e-05	198	70	5	8d629492d2199de8e036c19e9dacceb9c9e721a0
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDS1 SLC15A1 MALL XDH PBLD	1.51e-05	198	70	5	686d973483d027a3ffa2ad4430ba6e50f3d1378e
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDS1 SLC15A1 MALL XDH PBLD	1.51e-05	198	70	5	7696f042648bd53c0a019dfeea68808aa5898615
ToppCell	Parenchymal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Club\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	NEDD4L MALL XDH CP LTF	1.51e-05	198	70	5	5d57acbe0d245f8bd217eeea07af060092898fbd
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDS1 SLC15A1 MALL XDH PBLD	1.51e-05	198	70	5	a76366611f3561fc8aca7d62d1f0a0ea2bef7792
ToppCell	distal-2-Epithelial-Club\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NEDD4L MALL SEL1L3 XDH CP	1.51e-05	198	70	5	3055c03896fbfac82a3072e51c0c54d68131cf1a
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDS1 MALL XDH PBLD DMBT1	1.51e-05	198	70	5	8fbc461315986e357a0961a261ed10880637d6ad
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-mature_enterocytic\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDS1 SLC15A1 MALL XDH PBLD	1.51e-05	198	70	5	e67488695ce5e32ed8d149ed0b841540cbfdd3e2
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-mature_enterocytic\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC15A1 MALL XDH PBLD TM6SF2	1.51e-05	198	70	5	8fac96132663f54566136ef54b53684d31dfde32
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC15A1 MALL XDH PBLD TM6SF2	1.51e-05	198	70	5	c48b3f026b16d48b8eca9f74dc1e3f3f39a89322
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDS1 SLC15A1 MALL XDH PBLD	1.54e-05	199	70	5	1e6ac65ce7133de4872dcd7e98e2a9e57d3d61b7
ToppCell	3'-GW_trimst-1-SmallIntestine\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDS1 MALL XDH PBLD DMBT1	1.54e-05	199	70	5	c4a1e0cf3be867e7cebbd8bd3668bc2df391671b
ToppCell	cellseq2-Epithelial-Epithelial_Glandular\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NEDD4L CP LTF DMBT1 BACE2	1.54e-05	199	70	5	ca78fd6e310232b25b864ed02ff9242fe1aa8206
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CDS1 SLC15A1 MALL XDH PBLD	1.54e-05	199	70	5	38432e3ccbc546dc4c1dc2fb1d8d44f8a6de9424
ToppCell	Biopsy_Other_PF-Epithelial-SCGB3A2+_SCGB1A1+\|Biopsy_Other_PF / Sample group, Lineage and Cell type	NEDD4L MALL SEL1L3 XDH CP	1.54e-05	199	70	5	036244251d2dd39f8184b7095418c723c0524eff
ToppCell	5'-Adult-SmallIntestine-Epithelial-mature_enterocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC15A1 MALL PBLD DMBT1 TM6SF2	1.54e-05	199	70	5	01c2721bc82cd672e9477029b4a7ecc77e2f1b00
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CDS1 NEDD4L MALL CP DMBT1	1.58e-05	200	70	5	21d9cf3cd3696ad6b745c7c036798f04b6ce5160
ToppCell	distal-Epithelial\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CDS1 NEDD4L MALL CP DMBT1	1.58e-05	200	70	5	0a97080f694738bb882787cee21b91a4d5757b7a
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NEDD4L SLC15A1 MALL XDH PBLD	1.58e-05	200	70	5	3e13c9a4ba99a7dfbf738b0fb63fb54b4dee5897
ToppCell	Biopsy_Other_PF-Epithelial\|Biopsy_Other_PF / Sample group, Lineage and Cell type	CDS1 NEDD4L MALL CP DMBT1	1.58e-05	200	70	5	1ef4d5ae698fa721e0f510bf0d918bd8d3b00591
ToppCell	Lung_Parenchyma-Severe-Epithelial\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CDS1 NEDD4L MALL CP DMBT1	1.58e-05	200	70	5	33658d5d09e2eaff60f4dd88837d4252328eab63
ToppCell	Parenchyma_COVID-19-Epithelial-TX\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	CDS1 NEDD4L MALL CP DMBT1	1.58e-05	200	70	5	d5426cd318a8f90c0bd8f9804351ab230fafc995
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_airway_secretory\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	MALL SEL1L3 CP LTF BACE2	1.58e-05	200	70	5	8f811ddd84c037a250d124496b0fbb2e4717011c
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NEDD4L SLC15A1 MALL XDH PBLD	1.58e-05	200	70	5	73bfdf068a8ecbefc1e6afe9686df73658ee042f
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-11\|TCGA-Brain / Sample_Type by Project: Shred V9	CFAP54 SLC15A1 DBX1 PKHD1L1	2.20e-05	104	70	4	5114600bbadb5a0d31c164afd2e8c2a7865a1423
Computational	Metal / Ca ion binding.	CP LTF MMP3 MMP10 ITGAL ADH4	1.34e-05	133	43	6	MODULE_324
Computational	Metal ion (zinc) binding.	CP LTF MMP3 MMP10	2.94e-05	45	43	4	MODULE_280
Computational	Iron ion homeostasis.	CP LTF	6.89e-04	10	43	2	MODULE_540
Computational	Oxidoreductases.	FMO4 XDH CP PBLD ADH4	7.53e-04	182	43	5	MODULE_93
Computational	Genes in the cancer module 211.	MMP3 MMP10	8.40e-04	11	43	2	MODULE_211
Disease	fatty liver disease (implicated_via_orthology)	SEC63 TM6SF2 TM6SF1	5.02e-05	31	68	3	DOID:9452 (implicated_via_orthology)
Disease	diabetes mellitus (is_marker_for)	FUCA1 MMP3 MMP10	1.17e-04	41	68	3	DOID:9351 (is_marker_for)
Disease	lifestyle measurement, alcohol consumption measurement	CFAP54 ENTPD3 BACE2 ADCY8	1.47e-04	115	68	4	EFO_0007878, EFO_0010724
Disease	matrix metalloproteinase measurement	DYNC2H1 MMP3	4.02e-04	13	68	2	EFO_0004744
Disease	Saldino-Noonan Syndrome	C2CD3 DYNC2H1	4.68e-04	14	68	2	C0036069
Disease	Malignant tumor of colon	BRAF CP LTF DMBT1	5.06e-04	159	68	4	C0007102
Disease	matrix metalloproteinase 12 measurement	DYNC2H1 MMP3	7.82e-04	18	68	2	EFO_0010590
Disease	glioblastoma (is_implicated_in)	ADGRB1 DMBT1	1.40e-03	24	68	2	DOID:3068 (is_implicated_in)
Disease	Involutional paraphrenia	CACNA1C XDH	1.52e-03	25	68	2	C1571983
Disease	Psychosis, Involutional	CACNA1C XDH	1.52e-03	25	68	2	C1571984
Disease	Cerebral Astrocytoma	BRAF MMP3	1.52e-03	25	68	2	C0750935
Disease	Intracranial Astrocytoma	BRAF MMP3	1.52e-03	25	68	2	C0750936
Disease	Involutional Depression	CACNA1C XDH	1.52e-03	25	68	2	C0011574
Disease	paracentral lobule volume measurement	SLC15A1 ITGAV	1.52e-03	25	68	2	EFO_0010317
Disease	Pilocytic Astrocytoma	BRAF MMP3	1.52e-03	25	68	2	C0334583
Disease	Astrocytoma	BRAF MMP3	1.52e-03	25	68	2	C0004114
Disease	Juvenile Pilocytic Astrocytoma	BRAF MMP3	1.52e-03	25	68	2	C0280783
Disease	Diffuse Astrocytoma	BRAF MMP3	1.52e-03	25	68	2	C0280785
Disease	Grade I Astrocytoma	BRAF MMP3	1.52e-03	25	68	2	C1704230
Disease	Subependymal Giant Cell Astrocytoma	BRAF MMP3	1.52e-03	25	68	2	C0205768
Disease	Mixed oligoastrocytoma	BRAF MMP3	1.52e-03	25	68	2	C0547065
Disease	Childhood Cerebral Astrocytoma	BRAF MMP3	1.52e-03	25	68	2	C0338070
Disease	Gemistocytic astrocytoma	BRAF MMP3	1.64e-03	26	68	2	C0334581
Disease	Protoplasmic astrocytoma	BRAF MMP3	1.64e-03	26	68	2	C0334580
Disease	Fibrillary Astrocytoma	BRAF MMP3	1.64e-03	26	68	2	C0334582
Disease	Anaplastic astrocytoma	BRAF MMP3	1.77e-03	27	68	2	C0334579
Disease	Cerebral Hemorrhage	MMP3 ITGAV	1.90e-03	28	68	2	C2937358
Disease	Ischemia	XDH CP	1.90e-03	28	68	2	C0022116
Disease	coronary artery disease, factor VII measurement	DYNC2H1 SEMA5A ADH4	2.17e-03	111	68	3	EFO_0001645, EFO_0004619
Disease	bowel opening frequency	FFAR3 GPR42	2.18e-03	30	68	2	EFO_0600084

Protein segments in the cluster

Peptide	Gene	Start	Entry
FTDICSYPEYFVFTG	ADCY8	826	P40145
NPYSFQSDVYAFGIV	BRAF	631	P15056
FAVAGTPHSYIDTYF	BACE2	116	Q9Y5Z0
FFSEAFYEISQIFYG	CFAP54	2126	Q96N23
FFYGETVADYFATFV	CDS1	156	Q92903
FFGYFSAAAVFPANA	ADGRB1	51	O14514
KPVYHFFGTSTFSQY	ADH4	141	P08319
FTCNIPGTYFFTYHV	C1QL1	166	O75973
FFVPYFTYQGSDTDI	ATP10D	1211	Q9P241
EFPFAGTTFEYQRSF	ADAMTS18	811	Q8TE60
PFVAFAGFYYTASAL	ENTPD3	366	O75355
RADGLFYPSAFSFTY	RBPJL	461	Q9UBG7
YFTNTSSYEYTDVPF	OLFM2	396	O95897
GQTQAFDFYSRYFAP	PBLD	206	P30039
FSLGSAIAYSAYTFP	PAQR5	126	Q9NXK6
YSSDVFDIFPGTYQT	CP	1011	P00450
VFIFQFVNFYSSPVY	ANO7	591	Q6IWH7
FYFFSGSSQFEFDPN	MMP10	446	P09238
SSFAPNIYFLFFSYG	SLC16A9	96	Q7RTY1
IYQFVADSFPFYQRS	FOXI3	171	A8MTJ6
FGSVSVEFPYQYDFS	KIAA0100	821	Q14667
YYINSAASFFAFIAT	MALL	126	Q13021
AYFVEFLQSAFGYSP	PNLIP	146	P16233
FFYFFTGSSQLEFDP	MMP3	446	P08254
AFQFSYTAVFGAYTA	RCE1	231	Q9Y256
YFEGSFQPFIRSSYF	DBX1	141	A6NMT0
FTTGYTFSFPFFEEP	FMO4	326	P31512
FSYADFGPQFTARFF	FUCA1	101	P04066
IYSQFFPQGDSTTYA	KCNIP4	111	Q6PIL6
IYSQFFPQGDSSTYA	KCNIP2	131	Q9NS61
AVAFFPNGYAFTTGS	GNB2	231	P62879
AVSFFPNGYAFATGS	GNB4	231	Q9HAV0
SSVFYFASVPLYQGF	ATP9A	861	O75110
VDPFVYYFSSSGFQA	GPR42	271	O15529
SAGPFQLTASFDNYY	PCDHAC1	381	Q9H158
SQDGFFGPVFNYFTY	DYNC2H1	2756	Q8NCM8
YSPFSFPASDTYAAF	C2CD3	1791	Q4AC94
SYYQSDGRSAFPQTF	CACNA1C	1756	Q13936
TSGFPVYVYDSDQFV	EXTL3	191	O43909
GSYFGFAVDFFVPSA	ITGAV	46	P06756
EYTGYSFKFGFNEFS	DAPP1	86	Q9UN19
VDPFVYYFSSSGFQA	FFAR3	271	O14843
FYGSRLDYFQPSFES	BIN3	186	Q9NQY0
PDSDFEYSTQSYTGY	ELP3	116	Q9H9T3
EFAFYPSFASSYQAM	HOXC13	171	P31276
YSNEKPFTGFEAFYA	MASP2	121	O00187
GRAPYSFTFNSQFEF	GDF9	191	O60383
FYASGTFSSPSYPAY	DMBT1	1771	Q9UGM3
YRLYSSAVFGDFEQF	DHX37	681	Q8IY37
NGFSPSYEFFAVTRF	SLC22A15	156	Q8IZD6
DYSPGESFFTVFGVF	SLC12A8	226	A0AV02
SSYNASTYQFFPSGI	SLC15A1	511	P46059
PNFNTFYLEFGSAYT	SLC15A1	541	P46059
GFQAYDFPAVTTAQY	VARS1	1001	P26640
YNFSVFQIDAPSFAY	SEL1L3	936	Q68CR1
AFSSQEPYFSYSGAF	LTF	201	P02788
YSAYDFQHSGVFPSS	TMEM255A	291	Q5JRV8
QPDSFQHYRSVFYSF	NBPF15	621	Q8N660
FQTVPFYIFSESYGG	SCPEP1	156	Q9HB40
GFFFFAPASSYNLDV	ITGAL	16	P20701
VFGFPQSYIYEIFSN	TLR1	311	Q15399
SSYDIGNFTYFFFRE	SEMA5A	221	Q13591
FQYDDSGNTFFYFLT	SEC63	6	Q9UGP8
YSFETNSGNPFHYFS	XDH	1141	P47989
SFSYQFTSPGIHYYS	PKHD1L1	1466	Q86WI1
PFVYSHSFSPGYSFE	UGT2B10	166	P36537
YDPLYAVFAVFAFTS	TM6SF2	61	Q9BZW4
YAGQFFQPASNSDYY	YIPF7	86	Q8N8F6
FYNVTNHGFPIYTFS	TRIM6	446	Q9C030
DPLFYVYAVFGFTSV	TM6SF1	61	Q9BZW5
HAFQYVIYGTASFFF	PLP1	66	P60201
FNPYYGLFEYSATDN	NEDD4L	676	Q96PU5