Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionolfactory receptor activity

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 OR5H15 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR12D1 OR5H6 OR4C12 OR13C7 OR52Z1P OR5H1 OR52B6

1.61e-1843110224GO:0004984
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 NPSR1 P2RY8 OR5H15 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR12D1 OR5H6 OR4C12 OR13C7 OR52Z1P OR5H1 OR52B6

2.24e-1388410226GO:0004930
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 AXL OR5AN1 NPSR1 P2RY8 OR5H15 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 HMCN2 OR12D1 OR5H6 OR4C12 OR13C7 OR52Z1P OR5H1 OR52B6 PLXNB3 EPHA1

3.14e-12135310230GO:0004888
GeneOntologyMolecularFunctionodorant binding

OR5P2 OR8H3 OR5T1 OR5AU1 OR5D18 OR5AN1 OR5H15 OR12D1 OR5H6 OR5H1

9.83e-1012710210GO:0005549
GeneOntologyMolecularFunctionbisphosphoglycerate mutase activity

PGAM1 PGAM2 PGAM4

5.16e-0741023GO:0004082
GeneOntologyMolecularFunction2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity

PGAM1 PGAM2 PGAM4

5.16e-0741023GO:0046538
GeneOntologyMolecularFunctionphosphoglycerate mutase activity

PGAM1 PGAM2 PGAM4

5.16e-0741023GO:0004619
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-7 ERVK-21 ERVK-9 ERVK-18 ERVK-24

1.21e-06371025GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-7 ERVK-21 ERVK-9 ERVK-18 ERVK-24

1.38e-06381025GO:0070001
GeneOntologyMolecularFunctionintramolecular phosphotransferase activity

PGAM1 PGAM2 PGAM4

2.07e-05111023GO:0016868
GeneOntologyMolecularFunctionalpha-1,4-glucosidase activity

MGAM SI

2.56e-0451022GO:0004558
GeneOntologyMolecularFunctionintramolecular transferase activity

PGAM1 PGAM2 PGAM4

4.29e-04291023GO:0016866
GeneOntologyMolecularFunctionalpha-glucosidase activity

MGAM SI

5.34e-0471022GO:0090599
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 OR5H15 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR12D1 OR5H6 OR4C12 OR13C7 OR52Z1P OR5H1 OR52B6

4.98e-1943210024GO:0050911
GeneOntologyBiologicalProcesssensory perception of smell

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 OR5H15 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR12D1 OR5H6 OR4C12 OR13C7 OR52Z1P OR5H1 OR52B6

2.71e-1846510024GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 OR5H15 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR12D1 OR5H6 OR4C12 OR13C7 OR52Z1P OR5H1 OR52B6

7.10e-1848510024GO:0050907
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR5P2 OR8H3 OR5T1 CACNB3 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 OR5H15 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR12D1 OR5H6 OR4C12 OR13C7 OR52Z1P OR5H1 OR52B6

3.70e-1758210025GO:0050906
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 OR5H15 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR12D1 OR5H6 OR4C12 OR13C7 OR52Z1P OR5H1 OR52B6

4.12e-1752410024GO:0009593
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 OR5H15 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR12D1 OR5H6 OR4C12 OR13C7 OR52Z1P OR5H1 OR52B6

1.09e-1654710024GO:0007606
GeneOntologyBiologicalProcessdetection of stimulus

OR5P2 OR8H3 OR5T1 CACNB3 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 OR5H15 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR12D1 OR5H6 OR4C12 OR13C7 OR52Z1P OR5H1 OR52B6

5.43e-1572210025GO:0051606
GeneOntologyBiologicalProcesssensory perception

OR5P2 OR8H3 OR5T1 CACNB3 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 ESPNL OR5H15 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR12D1 OR5H6 DLG2 OR4C12 OR13C7 OR52Z1P OR5H1 OR52B6

7.66e-13107210027GO:0007600
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 NPSR1 P2RY8 OR5H15 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR12D1 OR5H6 OR4C12 OR13C7 OR52Z1P OR5H1 OR52B6

1.63e-09139510026GO:0007186
GeneOntologyBiologicalProcesspyridine nucleotide catabolic process

PGAM1 PGAM2 NUDT12 PGAM4 SIK2 FLCN

2.49e-051191006GO:0019364
GeneOntologyBiologicalProcesspyridine-containing compound catabolic process

PGAM1 PGAM2 NUDT12 PGAM4 SIK2 FLCN

3.00e-051231006GO:0072526
GeneOntologyBiologicalProcesspurine nucleoside diphosphate metabolic process

PGAM1 PGAM2 PGAM4 SIK2 FLCN DLG2

4.47e-051321006GO:0009135
GeneOntologyBiologicalProcesspurine ribonucleoside diphosphate metabolic process

PGAM1 PGAM2 PGAM4 SIK2 FLCN DLG2

4.47e-051321006GO:0009179
GeneOntologyBiologicalProcesscarbohydrate catabolic process

MGAM SI PGAM1 PGAM2 PGAM4 SIK2 FLCN

4.77e-051961007GO:0016052
GeneOntologyBiologicalProcessribonucleoside diphosphate metabolic process

PGAM1 PGAM2 PGAM4 SIK2 FLCN DLG2

6.98e-051431006GO:0009185
GeneOntologyBiologicalProcessribonucleoside triphosphate metabolic process

ATP6V1A PGAM1 PGAM2 NDUFV2 UCKL1 PGAM4 SIK2 FLCN

8.43e-052901008GO:0009199
GeneOntologyBiologicalProcessnucleoside diphosphate metabolic process

PGAM1 PGAM2 PGAM4 SIK2 FLCN DLG2

8.76e-051491006GO:0009132
GeneOntologyBiologicalProcessnucleoside triphosphate metabolic process

ATP6V1A PGAM1 PGAM2 NDUFV2 UCKL1 PGAM4 SIK2 FLCN

1.25e-043071008GO:0009141
GeneOntologyBiologicalProcessdisaccharide catabolic process

MGAM SI

1.39e-0441002GO:0046352
GeneOntologyBiologicalProcessglycolytic process

PGAM1 PGAM2 PGAM4 SIK2 FLCN

1.98e-041101005GO:0006096
GeneOntologyBiologicalProcessADP catabolic process

PGAM1 PGAM2 PGAM4 SIK2 FLCN

2.34e-041141005GO:0046032
GeneOntologyBiologicalProcessNAD catabolic process

PGAM1 PGAM2 NUDT12

2.35e-04251003GO:0019677
GeneOntologyBiologicalProcessATP metabolic process

ATP6V1A PGAM1 PGAM2 NDUFV2 PGAM4 SIK2 FLCN

2.57e-042571007GO:0046034
GeneOntologyBiologicalProcesspurine nucleotide catabolic process

PGAM1 PGAM2 NUDT12 PGAM4 SIK2 FLCN

2.61e-041821006GO:0006195
GeneOntologyBiologicalProcesspurine nucleoside diphosphate catabolic process

PGAM1 PGAM2 PGAM4 SIK2 FLCN

2.64e-041171005GO:0009137
GeneOntologyBiologicalProcesspurine ribonucleoside diphosphate catabolic process

PGAM1 PGAM2 PGAM4 SIK2 FLCN

2.64e-041171005GO:0009181
GeneOntologyBiologicalProcessADP metabolic process

PGAM1 PGAM2 PGAM4 SIK2 FLCN

2.97e-041201005GO:0046031
GeneOntologyBiologicalProcessribonucleoside diphosphate catabolic process

PGAM1 PGAM2 PGAM4 SIK2 FLCN

3.09e-041211005GO:0009191
GeneOntologyBiologicalProcesspurine-containing compound catabolic process

PGAM1 PGAM2 NUDT12 PGAM4 SIK2 FLCN

3.10e-041881006GO:0072523
GeneOntologyBiologicalProcessnucleoside diphosphate catabolic process

PGAM1 PGAM2 PGAM4 SIK2 FLCN

3.46e-041241005GO:0009134
GeneOntologyBiologicalProcessviral process

AXL ZNFX1 ERVK-7 ERVK-21 ERVK-9 ST6GALNAC2 DDX3X ERVK-24 TOP2A

4.25e-044641009GO:0016032
GeneOntologyBiologicalProcessnicotinamide nucleotide metabolic process

PGAM1 PGAM2 NUDT12 PGAM4 SIK2 FLCN

4.55e-042021006GO:0046496
GeneOntologyBiologicalProcesspyridine nucleotide metabolic process

PGAM1 PGAM2 NUDT12 PGAM4 SIK2 FLCN

4.55e-042021006GO:0019362
GeneOntologyBiologicalProcesspurine ribonucleoside triphosphate metabolic process

ATP6V1A PGAM1 PGAM2 NDUFV2 PGAM4 SIK2 FLCN

4.59e-042831007GO:0009205
GeneOntologyBiologicalProcessnucleotide catabolic process

PGAM1 PGAM2 NUDT12 PGAM4 SIK2 FLCN

5.31e-042081006GO:0009166
GeneOntologyBiologicalProcesspurine nucleoside triphosphate metabolic process

ATP6V1A PGAM1 PGAM2 NDUFV2 PGAM4 SIK2 FLCN

5.41e-042911007GO:0009144
GeneOntologyBiologicalProcesspyridine-containing compound metabolic process

PGAM1 PGAM2 NUDT12 PGAM4 SIK2 FLCN

5.58e-042101006GO:0072524
GeneOntologyBiologicalProcesspyruvate metabolic process

PGAM1 PGAM2 PGAM4 SIK2 FLCN

6.42e-041421005GO:0006090
GeneOntologyBiologicalProcessnucleoside phosphate catabolic process

PGAM1 PGAM2 NUDT12 PGAM4 SIK2 FLCN

6.47e-042161006GO:1901292
DomainOlfact_rcpt

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 OR5H15 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR5H6 OR4C12 OR5H1 OR52B6

5.27e-163939521IPR000725
DomainGPCR_Rhodpsn_7TM

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 NPSR1 P2RY8 OR5H15 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR5H6 OR4C12 OR5H1 OR52B6

2.28e-136709523IPR017452
Domain7tm_1

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 NPSR1 P2RY8 OR5H15 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR5H6 OR4C12 OR5H1 OR52B6

2.83e-136779523PF00001
DomainG_PROTEIN_RECEP_F1_1

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 NPSR1 P2RY8 OR5H15 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR5H6 OR4C12 OR5H1 OR52B6

3.61e-136859523PS00237
DomainG_PROTEIN_RECEP_F1_2

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 NPSR1 P2RY8 OR5H15 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR5H6 OR4C12 OR5H1 OR52B6

4.33e-136919523PS50262
DomainGPCR_Rhodpsn

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 NPSR1 P2RY8 OR5H15 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR5H6 OR4C12 OR5H1 OR52B6

4.46e-136929523IPR000276
DomainPhosphogly_mut1

PGAM1 PGAM2 PGAM4

5.08e-074953IPR005952
DomainPG/BPGM_mutase_AS

PGAM1 PGAM2 PGAM4

1.05e-059953IPR001345
DomainPGAM

PGAM1 PGAM2 PGAM4

1.49e-0510953SM00855
DomainPG_MUTASE

PGAM1 PGAM2 PGAM4

1.49e-0510953PS00175
DomainHis_Phos_1

PGAM1 PGAM2 PGAM4

2.71e-0512953PF00300
DomainHis_Pase_superF_clade-1

PGAM1 PGAM2 PGAM4

2.71e-0512953IPR013078
DomainHis_PPase_superfam

PGAM1 PGAM2 PGAM4

1.36e-0420953IPR029033
Domain-

PGAM1 PGAM2 PGAM4

1.36e-04209533.40.50.1240
DomainGlyco_hydro_31_CS

MGAM SI

1.53e-044952IPR030459
DomainNtCtMGAM_N

MGAM SI

1.53e-044952PF16863
DomainGal_mutarotase_N

MGAM SI

1.53e-044952IPR031727
DomainGLYCOSYL_HYDROL_F31_2

MGAM SI

2.53e-045952PS00707
DomainGlyco_hydro_31_AS

MGAM SI

3.79e-046952IPR030458
DomainGlyco_hydro_31

MGAM SI

5.29e-047952IPR000322
DomainGlyco_hydro_31

MGAM SI

5.29e-047952PF01055
DomainGLYCOSYL_HYDROL_F31_1

MGAM SI

5.29e-047952PS00129
DomainTrefoil

MGAM SI

7.03e-048952PF00088
DomainP_TREFOIL_1

MGAM SI

7.03e-048952PS00025
DomainP_trefoil_CS

MGAM SI

7.03e-048952IPR017957
DomainP_TREFOIL_2

MGAM SI

9.00e-049952PS51448
DomainPD

MGAM SI

9.00e-049952SM00018
Domain-

MGAM SI

1.37e-03119524.10.110.10
Domain-

ATP6V1A CACNB3 DNAH2 ZNFX1 BTAF1 ATAD2 DDX3X ABCA5 UCKL1 GAL3ST3 DLG2

1.41e-0374695113.40.50.300
DomainP_trefoil_dom

MGAM SI

1.63e-0312952IPR000519
DomainGal_mutarotase_SF_dom

MGAM SI

3.31e-0317952IPR011013
DomainP-loop_NTPase

ATP6V1A CACNB3 DNAH2 ZNFX1 BTAF1 ATAD2 DDX3X ABCA5 UCKL1 GAL3ST3 DLG2

3.82e-038489511IPR027417
Domain-

BTAF1 ATAD2 WDFY4 RANBP17 AP4B1

5.53e-032229551.25.10.10
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 OR5H15 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR5H6 OR4C12 OR52Z1P OR5H1 OR52B6

1.11e-144179022M4072
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR5H6 OR4C12 OR52B6

3.67e-123899019M14091
PathwayREACTOME_SENSORY_PERCEPTION

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 ESPNL OR5H15 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR5H6 OR4C12 OR52Z1P OR5H1 OR52B6

6.92e-126369023M41834
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR1A2 OR1N2 OR51E2 OR51D1 OR4C12

8.28e-0570905MM14984
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 OR5H15 OR1A2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR12D1 OR5H6 OR4C12 OR13C7 OR52Z1P OR5H1

2.86e-233401042211875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 OR5H15 OR1A2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR12D1 OR5H6 OR4C12 OR13C7 OR52Z1P OR5H1

2.86e-233401042211802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 OR5H15 OR1A2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR12D1 OR5H6 OR4C12 OR13C7 OR52Z1P OR5H1

3.47e-233431042232295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 OR5H15 OR1A2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR12D1 OR5H6 OR4C12 OR13C7 OR52Z1P OR5H1

4.20e-233461042214611657
Pubmed

The human olfactory receptor gene family.

OR5P2 OR8H3 OR5T1 OR4N5 OR5AU1 OR10P1 OR5D18 OR5AN1 OR1A2 OR2S2 OR52E2 OR1N2 OR51E2 OR52I1 OR51D1 OR13D1 OR5H6 OR4C12 OR52Z1P OR52B6

1.85e-165411042014983052
Pubmed

Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis.

PGAM1 PGAM2 PGAM4

2.60e-083104333914812
Pubmed

Developmental activation of phosphoglycerate mutase-2 in the testis of the mouse.

PGAM1 PGAM2 PGAM4

2.60e-08310432824255
Pubmed

Phosphoglycerate Mutase Cooperates with Chk1 Kinase to Regulate Glycolysis.

PGAM1 PGAM2 PGAM4

2.60e-083104332634742
Pubmed

Mouse phosphoglycerate mutase M and B isozymes: cDNA cloning, enzyme activity assay and mapping.

PGAM1 PGAM2 PGAM4

2.60e-083104311250083
Pubmed

Odorant and vomeronasal receptor genes in two mouse genome assemblies.

OR5P2 OR5AU1 OR5AN1 OR1A2 OR12D1 OR13C7

9.71e-0874104615081110
Pubmed

Deacetylation of phosphoglycerate mutase in its distinct central region by SIRT2 down-regulates its enzymatic activity.

PGAM1 PGAM2 PGAM4

1.04e-074104325195573
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-21 ERVK-9 ERVK-18 ERVK-24

2.24e-0718104418664271
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-7 ERVK-21 ERVK-18

2.59e-075104312629516
Pubmed

Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2.

PGAM1 PGAM2 PGAM4

1.44e-068104324567357
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR5AU1 OR10P1 OR5D18 OR1A2 OR2S2 OR1N2 OR4C12

4.51e-06219104712213199
Pubmed

Personal receptor repertoires: olfaction as a model.

OR2S2 OR12D1 OR5H6 OR13C7

5.15e-0638104422908908
Pubmed

Contribution of the Individual Small Intestinal α-Glucosidases to Digestion of Unusual α-Linked Glycemic Disaccharides.

MGAM SI

8.86e-062104227480812
Pubmed

Isolation of a cDNA encoding the muscle-specific subunit of human phosphoglycerate mutase.

PGAM1 PGAM2

8.86e-06210422822696
Pubmed

Phosphoglycerate mutase isozyme marker for tissue differentiation in man.

PGAM1 PGAM2

8.86e-06210424827367
Pubmed

Interaction between the α-glucosidases, sucrase-isomaltase and maltase-glucoamylase, in human intestinal brush border membranes and its potential impact on disaccharide digestion.

MGAM SI

8.86e-062104236968271
Pubmed

Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains.

MGAM SI

8.86e-062104220356844
Pubmed

PGAM1 is Involved in Spermatogenic Dysfunction and Affects Cell Proliferation, Apoptosis, and Migration.

PGAM1 PGAM4

8.86e-062104225701843
Pubmed

Gene network of a phosphoglycerate mutase in muscle wasting in mice.

PGAM1 PGAM4

8.86e-062104225644094
Pubmed

PGAM1 knockdown is associated with busulfan‑induced hypospermatogenesis and spermatogenic cell apoptosis.

PGAM1 PGAM4

8.86e-062104230720109
Pubmed

Phosphoglycerate Mutase 1 Promotes Cell Proliferation and Neuroblast Differentiation in the Dentate Gyrus by Facilitating the Phosphorylation of cAMP Response Element-Binding Protein.

PGAM1 PGAM4

8.86e-062104230460638
Pubmed

T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses.

PGAM1 PGAM4

8.86e-062104232709928
Pubmed

Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue.

PGAM1 PGAM4

8.86e-062104235521515
Pubmed

A single nucleotide polymorphism within the novel sex-linked testis-specific retrotransposed PGAM4 gene influences human male fertility.

PGAM1 PGAM4

8.86e-062104222590500
Pubmed

A precise localization of a mouse gene encoding increased phosphoglycerate mutase activity (Pgam1e1) on chromosome 19.

PGAM1 PGAM4

8.86e-06210428829551
Pubmed

TRF2-mediated telomere protection is dispensable in pluripotent stem cells.

PGAM1 PPIL1 PGAM4

9.23e-0614104333239785
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-7 ERVK-21 ERVK-9 ERVK-18 ERVK-24

9.64e-0694104521542922
Pubmed

Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.

MGAM ACO1 PGAM1 PGAM2 PGAM4

2.46e-05114104528245920
Pubmed

PGAM1 deficiency ameliorates myocardial infarction remodeling by targeting TGF-β via the suppression of inflammation, apoptosis and fibrosis.

PGAM1 PGAM4

2.65e-053104233168191
Pubmed

The Inhibition of Glycolysis in T Cells by a Jak Inhibitor Ameliorates the Pathogenesis of Allergic Contact Dermatitis in Mice.

PGAM1 PGAM4

2.65e-053104237028703
Pubmed

Molecular cloning and nucleotide sequence of murine 2,3-bisphosphoglycerate mutase cDNA.

PGAM1 PGAM4

2.65e-05310422847721
Pubmed

Partial characterization of murine intestinal maltase-glucoamylase.

MGAM SI

2.65e-053104212150962
Pubmed

Evidence for an alternative glycolytic pathway in rapidly proliferating cells.

PGAM1 PGAM4

2.65e-053104220847263
Pubmed

Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly.

ACO1 NFS1

2.65e-053104216527810
Pubmed

Transcriptomics and Metabonomics Identify Essential Metabolic Signatures in Calorie Restriction (CR) Regulation across Multiple Mouse Strains.

PGAM1 PGAM4

2.65e-053104224958256
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

ATP6V1A UGGT1 CTSA YES1 DDX3X MYOF MISP DOCK7 CDC73 TOP2A

2.98e-056601041032780723
Pubmed

An analysis of expression patterns of genes encoding proteins with catalytic activities.

ACO1 PGAM1 PGAM2 PGAM4

5.00e-0567104417626619
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-7 ERVK-24

5.29e-054104210469592
Pubmed

Cytosolic proteins lose solubility as amyloid deposits in a transgenic mouse model of Alzheimer-type amyloidosis.

PGAM1 PGAM4

5.29e-054104223512986
Pubmed

Tagging genes with cassette-exchange sites.

UGGT1 BIRC6 RANBP17 PPIL1 FLCN CDC73 MED23

6.90e-05335104715741177
Pubmed

Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.

OR8H3 OR5AU1 OR5H1

7.21e-0527104332061665
Pubmed

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

UGGT1 PGAM1 BIRC6 MYOF PGAM4 USP4 SEC23A

8.14e-05344104730333137
Pubmed

Differential impact of Lhx2 deficiency on expression of class I and class II odorant receptor genes in mouse.

OR5P2 OR51E2 OR52I1

1.33e-0433104317350283
Pubmed

Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.

PGAM1 MYOF PGAM4 DOCK7

1.52e-0489104427034005
Pubmed

Phosphoinositide-specific phospholipase C β 1b (PI-PLCβ1b) interactome: affinity purification-mass spectrometry analysis of PI-PLCβ1b with nuclear protein.

PGAM1 PGAM2 DDX3X NDUFV2 PGAM4

1.59e-04169104523665500
Pubmed

Novel human G-protein-coupled receptors.

OR52I1 OR51D1

1.84e-047104212732197
Pubmed

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

BIRC6 MYOF MED23 PLXNB3

2.66e-04103104410574462
Pubmed

Small subfamily of olfactory receptor genes: structural features, expression pattern and genomic organization.

OR2S2 OR13C7

3.14e-049104210452948
Pubmed

Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs.

NUDT12 PER3

3.14e-049104231875550
Pubmed

Galactosaminogalactan activates the inflammasome to provide host protection.

DDX3X GSDMD

3.14e-049104233268895
Pubmed

A PAK5-DNPEP-USP4 axis dictates breast cancer growth and metastasis.

USP4 TOP2A

3.14e-049104231219614
Pubmed

Screen for genes regulated during early kidney morphogenesis.

AXL GSDMD

3.14e-049104210322635
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

HIPK1 DNAH2 YES1 PGAM1 ADAMTS6 PPIL1 PGAM4 USP4 SEC23A

3.51e-04730104934857952
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

UGGT1 ZNFX1 BTAF1 MYOF DOCK7

3.63e-04202104533005030
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

ATP6V1A MGAM AXL ACO1 SI CTSA PGAM1 PGAM2 MYOF PGAM4 MUC4

3.65e-0410701041123533145
Pubmed

Glyceroneogenesis is the dominant pathway for triglyceride glycerol synthesis in vivo in the rat.

PGAM1 PGAM4

3.92e-0410104218662986
Pubmed

FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.

ACO1 MRPL39 DCTN4 TOP2A SEC23A

4.53e-04212104533462405
Pubmed

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

CACNB3 YES1 DLG2

4.60e-0450104319807924
Pubmed

Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.

NDUFV2 FAT1 PER3

5.16e-0452104319328558
Pubmed

Organization and evolutionary relatedness of OR37 olfactory receptor genes in mouse and human.

OR2S2 OR13C7

5.73e-0412104212906860
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-21 ERVK-9

5.73e-0412104214557543
Pubmed

Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT).

CHAF1B BTAF1 CDC73

6.09e-0455104327114453
Pubmed

Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways.

PGAM1 PGAM2 NDUFV2 PGAM4

6.80e-04132104422496890
Pubmed

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

CHAF1B DDX3X DOCK7 SIK2 FLCN

6.80e-04232104525515538
Pubmed

Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.

ACO1 SLC4A3

7.87e-0414104224811271
Pubmed

The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.

AXL MYOF FAT1

1.18e-0369104326792178
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

ATP6V1A ZNFX1 PGAM1 NDUFV2 OR52E2 MISP PGAM4 DOCK7 DLG2 USP4 DCTN4 SEC23A

1.18e-0314311041237142655
Pubmed

Systematic protein-protein interaction mapping for clinically relevant human GPCRs.

NPSR1 SI CTSA SLC4A3 UCKL1 TMEM70 USP4 YIPF6

1.19e-03697104828298427
Pubmed

WDFY4 is required for cross-presentation in response to viral and tumor antigens.

ATP6V1A WDFY4 DDX3X DCTN4

1.26e-03156104430409884
Pubmed

The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2.

DDX3X TOP2A

1.31e-0318104219961560
Pubmed

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.

CHAF1B TOP2A

1.46e-0319104220504901
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

AXL NFS1 YES1 MYOF SLC35B4 SIK2 FLCN CDC73 DCTN4

1.66e-03910104936736316
Pubmed

Proteolipid protein is required for transport of sirtuin 2 into CNS myelin.

ATP6V1A PGAM1 NDUFV2 PGAM4

1.70e-03169104417634366
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

ATP6V1A CHAF1B DNAH2 DDX3X MYOF MISP PPIL1 MED23

1.95e-03754104835906200
Pubmed

The protein tyrosine kinase family of the human genome.

AXL YES1 EPHA1

2.01e-0383104311114734
Pubmed

The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.

ATP6V1A CHAF1B DDX3X CDC73 DCTN4

2.06e-03298104530737378
Pubmed

Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex.

AXL CTSA

2.34e-0324104235543156
Pubmed

14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking.

ACO1 UGGT1 DOCK7 SEC23A

2.40e-03186104414744259
Pubmed

Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.

ACO1 UCKL1 CDC73

2.45e-0389104323891004
Pubmed

Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.

ATP6V1A CHAF1B NFS1 AP4B1 MED23 TOP2A

2.48e-03454104633226137
Pubmed

Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation.

ATP6V1A PGAM1

2.54e-0325104219405953
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

ACO1 UGGT1 CTSA YES1 PGAM1 DDX3X MRPL39 MYOF MISP TOP2A SEC23A

2.63e-0313671041132687490
Pubmed

Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly.

DDX3X MYOF SEC23A

2.77e-0393104338245532
Pubmed

Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.

DOCK7 MUC4 TOP2A

2.95e-0395104324029230
Cytoband11p15.4

OR5P2 OR52E2 OR52I1 OR51D1 OR52Z1P OR52B6

6.75e-06200104611p15.4
CytobandEnsembl 112 genes in cytogenetic band chr3q11

OR5H15 OR5H6 OR5H1

2.58e-04541043chr3q11
CytobandEnsembl 112 genes in cytogenetic band chr11p15

OR5P2 OR52E2 OR51E2 OR52I1 OR51D1 OR52Z1P OR52B6

3.10e-045641047chr11p15
Cytoband3q12.1

OR5H15 OR5H6

1.04e-032110423q12.1
GeneFamilyOlfactory receptors, family 5

OR5P2 OR5T1 OR5AU1 OR5D18 OR5AN1 OR5H15 OR5H6 OR5H1

3.37e-08112808152
GeneFamilyBisphosphoglycerate phosphatases

PGAM1 PGAM2 PGAM4

3.33e-0748031082
GeneFamilyOlfactory receptors, family 52

OR52E2 OR52I1 OR52Z1P OR52B6

6.47e-0549804165
DiseaseBicuspid aortic valve

HMCN2 MUC4

2.75e-053902HP_0001647
DiseaseMitochondrial Encephalomyopathies

NDUFV2 TMEM70

2.55e-048902C0162666
Diseaseairway responsiveness measurement

WDFY4 DZIP3

2.43e-0324902EFO_0006897
Diseasepallidum volume

BIRC6 DLG2

2.64e-0325902EFO_0006933
DiseaseDegenerative polyarthritis

ACO1 DDX3X SEC23A

2.92e-0393903C0029408
DiseaseOsteoarthrosis Deformans

ACO1 DDX3X SEC23A

2.92e-0393903C0086743

Protein segments in the cluster

PeptideGeneStartEntry
AGPYPLIITIIMLTL

ABCA5

391

Q8WWZ7
LIEPVYPDIIRMISV

PPP2R5B

121

Q15173
LGQPISMVLPQVIGY

ACO1

231

P21399
TYIVRVRMLTPLGPG

EPHA1

511

P21709
LEVPVPVRFLFVMLG

SLC4A3

546

P48751
CVKPPYMLVVGNIVI

ERVK-18

271

O42043
CVKPPYMLVVGNIVI

ERVK-9

381

Q9UKH3
RLPMLYPEVIQQVSA

BIRC6

4086

Q9NR09
YDVVPSMRPVVLVGP

CACNB3

171

P54284
VTVPYRVVDQPLKLM

CDC73

421

Q6P1J9
GMLVPELAIPVVYLL

GSDMD

361

P57764
SLRMPGVQEYIQQPI

AP4B1

111

Q9Y6B7
RPVVETGVELMSLPY

CHAF1B

301

Q13112
YQPMSFRPRILIVGE

ATAD2

786

Q6PL18
SLPRGGYMEVVQIPR

ADAMTS6

726

Q9UKP5
SFIINLEPPVLMYVL

RANBP17

901

Q9H2T7
NMVEPLFYTVIIPLL

OR5H15

271

A6NDH6
VVIPMLNPLIYSLRN

OR5D18

281

Q8NGL1
MLRNPAIAVALPVVY

P2RY8

16

Q86VZ1
IHILVGSLYVLVPPM

OR52Z1P

256

P0C646
IMGNIELTRYTRPTP

DDX3X

191

O00571
VVLVYVKILPPEMQL

FAT1

2686

Q14517
MDRVTRYPILGIPQA

MISP

1

Q8IVT2
PMLNPVIYGVRTKQI

OR52E2

286

Q8NGJ4
MVISEFQYRPRGPVI

MUC4

5231

Q99102
QYLREVAQPVPLLMT

ESPNL

321

Q6ZVH7
VITVMYVAVTPALNP

OR1A2

271

Q9Y585
GVVTPMLNPIIYSLR

OR13C7

286

P0DN81
VVPMLNPVVYTLRNA

OR4C12

276

Q96R67
LGRPTQEYVMPILGL

MAGEE2

396

Q8TD90
EVGPVLRPLYMDVQA

NFS1

51

Q9Y697
LRTMLPVGCVRIIPY

FLCN

391

Q8NFG4
IPLTIISIMYGIVIR

NPSR1

221

Q6W5P4
IMLVDPVRQPYRVKV

HIPK1

321

Q86Z02
GPLMRVLVVTIAPIY

HMCN2

4441

Q8NDA2
VLPVDPRYQLSVLSM

LONRF1

736

Q17RB8
TQQYTELIGRPVMVP

MGAM

1226

O43451
NVRVMLVPSPRYVGL

KIAA1109

256

Q2LD37
TPERILMTYQVPERV

PER3

1111

P56645
MSQRELPVPIYVTQG

PLXNB3

756

Q9ULL4
VVMANTYLLLPPVVN

OR51D1

286

Q8NGF3
VRVVMGDIYLLLPPV

OR51E2

271

Q9H255
MLNPVIYGVRTKPIL

OR52B6

306

Q8NGF0
TVIFPLMNPVIYTLR

OR4N5

276

Q8IXE1
VETIYGNGIMRIPLP

MED23

496

Q9ULK4
VIPNRVKMLPYFGII

DNAJC28

21

Q9NX36
MELNLPTGIPIVYEL

PGAM4

206

Q8N0Y7
GVVTPMLNPIIYSLR

OR2S2

286

Q9NQN1
VVIPMLNPLIYSLRN

OR5AN1

281

Q8NGI8
SVYLGIPVPEIIQRM

DZIP3

566

Q86Y13
IPVPEIIQRMLSCYQ

DZIP3

571

Q86Y13
DQVAPVFYTIVIPML

OR8H3

271

Q8N146
ITAIMYTVVTPVLNP

OR12D1

266

P0DN82
DMVEPLFYTVIIPLL

OR5H1

271

A6NKK0
VIVPLLNPMIYSLRN

OR5H6

296

Q8NGV6
VMPTLVIPAHYVRLG

FAM171A2

536

A8MVW0
SVLYTVVIPMLNPLI

OR5P2

271

Q8WZ92
VVIPMLNPLIYSLRN

OR5P2

276

Q8WZ92
GIYIPTLAVLVMQDP

CTSA

181

P10619
VSIFYTIVIPMLNPI

OR5T1

286

Q8NG75
TIVIPMLNPIIYSLR

OR5T1

291

Q8NG75
ELERLMPPSTVYVTI

GAL3ST3

136

Q96A11
LYLPLIGIIMETVPQ

DOCK7

1241

Q96N67
VPYIVLLVVPVLGRM

BTAF1

1181

O14981
CVKPPYMLVVGNIVI

ERVK-24

271

P61566
CVKPPYMLVVGNIVI

ERVK-7

271

P61567
MNYIVPILVLPRVNE

BPI

436

P17213
CVKPPYMLVVGNIVI

ERVK-21

381

P61565
EINYTRPVIILGPMK

DLG2

676

Q15700
VAVNYIPEVRIMSIP

DCTN4

301

Q9UJW0
YGRPPAQVEIVMQAV

DNAH2

3116

Q9P225
VRMINSPVGNIPDIY

DUSP21

166

Q9H596
MELNLPTGIPIVYEL

PGAM1

206

P18669
MVIIPTLNPFIYSLR

OR1N2

296

Q8NGR9
VITPMLNPIIYTLRN

OR10P1

281

Q8NGE3
GVVSPMLNPIIYSLR

OR13D1

311

Q8NGV5
VIIPATLNPIIYGMR

OR52I1

286

Q8NGK6
QRLMLQVGLIYPASP

PARS2

71

Q7L3T8
EYMVNLVRAPEVPVI

MRPL39

161

Q9NYK5
LYEIPVIGVTLPIMW

SLC35B4

226

Q969S0
MELNLPTGIPIVYEL

PGAM2

206

P15259
AVIYTVVIPVLNPLM

OR5AU1

326

Q8NGC0
VVIPVLNPLMYSLRN

OR5AU1

331

Q8NGC0
DYVMLRSAILGVPVP

ST6GALNAC2

236

Q9UJ37
MLIEVPVQRPVLYPQ

SIK2

271

Q9H0K1
TSYPRVDPVVIMQVI

NUDT12

316

Q9BQG2
AMEIFIQPTPIVTYR

SI

301

P14410
SIEYVVLRGPQMPLI

SEC23A

116

Q15436
VLRGPQMPLIFLYVV

SEC23A

121

Q15436
EILPMPYVTEATRVQ

CHPF2

476

Q9P2E5
RPTQYRVTVPLMGAV

USP4

501

Q13107
PGPVNFMVRLFVVIV

YIPF6

176

Q96EC8
MVSLGLTVYRPTVIP

ZNF287

206

Q9HBT7
IAIPAMIIGIPVYVG

RNF19A

381

Q9NV58
PPNVYLETSMGIIVL

PPIL1

11

Q9Y3C6
APRLVITNGMVIPNY

UROC1

171

Q96N76
PGVVCIMVRLLPRLY

WDFY4

831

Q6ZS81
RLGDQPVYLPTQMLV

AXL

636

P30530
IMLPPRNRGTVTYIA

ATP6V1A

166

P38606
VQVPRRGAILPMLYA

TTTY12

36

Q9BZ98
VGMITEPIPDIRNQY

ZNFX1

226

Q9P2E3
YIPIIPMVLINGAEG

TOP2A

841

P11388
QYIQPTMRLADIVVP

UCKL1

266

Q9NWZ5
PEVMIPVFDILLGRI

UBE4A

266

Q14139
VPLPIQIIFYGIMGS

TMEM70

136

Q9BUB7
VVEYIMNQPNVVPRI

UGGT1

681

Q9NYU2
VPYPGMVNREVLEQV

YES1

471

P07947
VPPVRVYGPDCVVLM

ZIC5

11

Q96T25
YMVPQGIRPVVQLTA

MYOF

1291

Q9NZM1
VAEVLQVPPMRVYEV

NDUFV2

101

P19404