Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transporter activity	SLC17A2 ABCC3 BEST1 SLC9A4 AQP12A TRPM5 CLCNKA CLCNKB CLN3 KCNJ10 SLC19A3 SLC44A2 SLC5A7 SEC63 SLC7A11 SLC37A4 AQP12B TPCN1 SLC52A3	1.52e-08	1289	65	19	GO:0005215
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC17A2 ABCC3 BEST1 SLC9A4 AQP12A TRPM5 CLCNKA CLCNKB KCNJ10 SLC19A3 SLC44A2 SLC5A7 SEC63 SLC7A11 SLC37A4 AQP12B TPCN1 SLC52A3	2.38e-08	1180	65	18	GO:0022857
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC17A2 ABCC3 BEST1 SLC9A4 AQP12A TRPM5 CLCNKA CLCNKB KCNJ10 SLC5A7 SLC37A4 AQP12B TPCN1	8.13e-07	758	65	13	GO:0015318
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	SLC17A2 ABCC3 BEST1 CLCNKA CLCNKB SLC37A4	1.96e-05	171	65	6	GO:0015103
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC17A2 SLC9A4 TRPM5 SLC5A7 TPCN1	2.37e-04	171	65	5	GO:0015081
GeneOntologyMolecularFunction	choline transmembrane transporter activity	SLC44A2 SLC5A7	2.88e-04	8	65	2	GO:0015220
GeneOntologyMolecularFunction	channel activity	BEST1 AQP12A TRPM5 CLCNKA CLCNKB KCNJ10 AQP12B TPCN1	2.93e-04	525	65	8	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	BEST1 AQP12A TRPM5 CLCNKA CLCNKB KCNJ10 AQP12B TPCN1	2.97e-04	526	65	8	GO:0022803
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	ABCC3 BEST1 SLC19A3 SLC7A11 SLC37A4 SLC52A3	3.79e-04	293	65	6	GO:0008514
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC17A2 SLC9A4 SLC44A2 SLC5A7 SLC7A11 SLC37A4	4.00e-04	296	65	6	GO:0015291
GeneOntologyMolecularFunction	voltage-gated chloride channel activity	CLCNKA CLCNKB	5.63e-04	11	65	2	GO:0005247
GeneOntologyMolecularFunction	gated channel activity	BEST1 TRPM5 CLCNKA CLCNKB KCNJ10 TPCN1	7.54e-04	334	65	6	GO:0022836
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC17A2 ABCC3 SLC9A4 SLC44A2 SLC5A7 SLC7A11 SLC37A4	8.95e-04	477	65	7	GO:0022804
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC17A2 BEST1 SLC9A4 TRPM5 CLCNKA CLCNKB KCNJ10 SLC5A7 TPCN1	1.02e-03	793	65	9	GO:0015075
GeneOntologyMolecularFunction	sulfur compound transmembrane transporter activity	ABCC3 SLC19A3 SLC7A11	1.04e-03	61	65	3	GO:1901682
GeneOntologyMolecularFunction	antiporter activity	SLC9A4 SLC44A2 SLC7A11 SLC37A4	1.07e-03	138	65	4	GO:0015297
GeneOntologyMolecularFunction	water channel activity	AQP12A AQP12B	1.37e-03	17	65	2	GO:0015250
GeneOntologyMolecularFunction	voltage-gated monoatomic anion channel activity	CLCNKA CLCNKB	1.37e-03	17	65	2	GO:0008308
GeneOntologyMolecularFunction	water transmembrane transporter activity	AQP12A AQP12B	1.91e-03	20	65	2	GO:0005372
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR8K1 HTR2A GPR21 MAS1 FFAR3 GPR42 MCHR2 APLNR OR9G9	2.16e-03	884	65	9	GO:0004930
GeneOntologyMolecularFunction	organic cation transmembrane transporter activity	SLC19A3 SLC44A2 SLC5A7	2.51e-03	83	65	3	GO:0015101
GeneOntologyMolecularFunction	phosphate transmembrane transporter activity	SLC17A2 SLC37A4	2.75e-03	24	65	2	GO:0005315
GeneOntologyMolecularFunction	chloride channel activity	BEST1 CLCNKA CLCNKB	2.78e-03	86	65	3	GO:0005254
GeneOntologyMolecularFunction	voltage-gated channel activity	CLCNKA CLCNKB KCNJ10 TPCN1	3.05e-03	184	65	4	GO:0022832
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	BEST1 TRPM5 KCNJ10 TPCN1	3.62e-03	193	65	4	GO:0015276
GeneOntologyMolecularFunction	monoatomic ion channel activity	BEST1 TRPM5 CLCNKA CLCNKB KCNJ10 TPCN1	3.75e-03	459	65	6	GO:0005216
GeneOntologyMolecularFunction	ligand-gated channel activity	BEST1 TRPM5 KCNJ10 TPCN1	3.89e-03	197	65	4	GO:0022834
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC17A2 SLC9A4 TRPM5 KCNJ10 SLC5A7 TPCN1	4.00e-03	465	65	6	GO:0046873
GeneOntologyMolecularFunction	metallocarboxypeptidase activity	CPO CPB1	4.57e-03	31	65	2	GO:0004181
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	TRPM5 TPCN1	4.57e-03	31	65	2	GO:0099604
GeneOntologyMolecularFunction	monoatomic anion channel activity	BEST1 CLCNKA CLCNKB	4.62e-03	103	65	3	GO:0005253
GeneOntologyMolecularFunction	modified amino acid transmembrane transporter activity	SLC19A3 SLC7A11	5.16e-03	33	65	2	GO:0072349
GeneOntologyMolecularFunction	vitamin transmembrane transporter activity	SLC19A3 SLC52A3	6.12e-03	36	65	2	GO:0090482
GeneOntologyBiologicalProcess	transepithelial chloride transport	BEST1 CLCNKA CLCNKB	3.53e-06	10	65	3	GO:0030321
GeneOntologyBiologicalProcess	transepithelial transport	BEST1 SLC9A4 CLCNKA CLCNKB	6.12e-06	38	65	4	GO:0070633
GeneOntologyBiologicalProcess	organic cation transport	FFAR3 CLN3 GPR42 SLC19A3 SLC44A2 SLC5A7	6.39e-06	145	65	6	GO:0015695
GeneOntologyBiologicalProcess	chemical homeostasis	SLC35G1 SLC9A4 HTR2A GPR21 FFAR3 CLN3 GPR42 KCNJ10 APLNR LRP1 SLC7A11 SLC37A4 ADCY5 HYAL2	2.75e-05	1249	65	14	GO:0048878
GeneOntologyBiologicalProcess	positive regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	2.93e-05	3	65	2	GO:0002879
GeneOntologyBiologicalProcess	positive regulation of inflammatory response	HTR2A FFAR3 GPR42 NLRP1 TLR6 HYAL2	3.24e-05	193	65	6	GO:0050729
GeneOntologyBiologicalProcess	organic anion transport	SLC17A2 ABCC3 BEST1 CLN3 KCNJ10 SLC19A3 SLC7A11 SLC37A4 SLC52A3	3.25e-05	515	65	9	GO:0015711
GeneOntologyBiologicalProcess	regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	5.84e-05	4	65	2	GO:0002877
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	SLC17A2 SLC35G1 BEST1 SLC9A4 TRPM5 HTR2A CLCNKA CLCNKB KCNJ10 APLNR SLC37A4 TPCN1	6.93e-05	1017	65	12	GO:0098660
GeneOntologyBiologicalProcess	acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	9.72e-05	5	65	2	GO:0002525
GeneOntologyBiologicalProcess	organic hydroxy compound transport	ABCC3 HTR2A FFAR3 GPR42 SLC19A3 SLC44A2 LRP1	1.31e-04	358	65	7	GO:0015850
GeneOntologyBiologicalProcess	water transport	AQP12A HYAL2 AQP12B	1.39e-04	32	65	3	GO:0006833
GeneOntologyBiologicalProcess	positive regulation of neuronal action potential	FFAR3 GPR42	1.45e-04	6	65	2	GO:1904457
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	SLC17A2 SLC35G1 ABCC3 BEST1 SLC9A4 TRPM5 HTR2A CLCNKA CLCNKB KCNJ10 APLNR TPCN1	1.65e-04	1115	65	12	GO:0034220
GeneOntologyBiologicalProcess	sodium ion transport	SLC17A2 SLC9A4 TRPM5 CLCNKB SLC5A7 TPCN1	2.27e-04	275	65	6	GO:0006814
GeneOntologyBiologicalProcess	metal ion transport	SLC17A2 SLC35G1 BEST1 SLC9A4 TRPM5 HTR2A CLCNKB KCNJ10 APLNR SLC5A7 TPCN1	2.66e-04	1000	65	11	GO:0030001
GeneOntologyBiologicalProcess	regulation of glutamine family amino acid metabolic process	CLN3 SLC7A11	2.70e-04	8	65	2	GO:0000820
GeneOntologyBiologicalProcess	monoatomic anion transport	SLC17A2 ABCC3 BEST1 CLCNKA CLCNKB	2.79e-04	183	65	5	GO:0006820
GeneOntologyBiologicalProcess	monoatomic ion transport	SLC17A2 SLC35G1 ABCC3 BEST1 SLC9A4 TRPM5 HTR2A CLCNKA CLCNKB KCNJ10 APLNR SLC5A7 TPCN1	3.04e-04	1374	65	13	GO:0006811
GeneOntologyBiologicalProcess	fluid transport	AQP12A HYAL2 AQP12B	3.14e-04	42	65	3	GO:0042044
GeneOntologyBiologicalProcess	regulation of heart rate by chemical signal	FFAR3 GPR42	3.47e-04	9	65	2	GO:0003062
GeneOntologyBiologicalProcess	amide transport	FFAR3 CLN3 GPR42 SLC19A3 LRP1 SLC7A11 ADCY5	3.48e-04	420	65	7	GO:0042886
GeneOntologyBiologicalProcess	regulation of protein transport	ZDHHC2 FFAR3 CLN3 GPR42 LRP1 SLC7A11 ADCY5 HYAL2	3.64e-04	560	65	8	GO:0051223
GeneOntologyBiologicalProcess	renal absorption	CLCNKA CLCNKB HYAL2	3.86e-04	45	65	3	GO:0070293
GeneOntologyBiologicalProcess	regulation of AMPA glutamate receptor clustering	ZDHHC2 SLC7A11	4.33e-04	10	65	2	GO:1904717
GeneOntologyBiologicalProcess	regulation of glutamate receptor clustering	ZDHHC2 SLC7A11	4.33e-04	10	65	2	GO:0106104
GeneOntologyBiologicalProcess	choline transport	SLC44A2 SLC5A7	4.33e-04	10	65	2	GO:0015871
GeneOntologyBiologicalProcess	response to nitrogen compound	TMEM129 BTG2 HTR2A GPR21 MAS1 FFAR3 GPR42 MARCHF6 LRP1 NLRP1 TLR6 ADCY5	5.51e-04	1272	65	12	GO:1901698
GeneOntologyBiologicalProcess	dicarboxylic acid transport	BEST1 KCNJ10 SLC19A3 SLC7A11	5.61e-04	120	65	4	GO:0006835
GeneOntologyBiologicalProcess	cellular response to UV-B	NLRP1 HYAL2	6.32e-04	12	65	2	GO:0071493
GeneOntologyBiologicalProcess	regulation of chemokine production	FFAR3 GPR42 LRP1 SLC37A4	6.54e-04	125	65	4	GO:0032642
GeneOntologyBiologicalProcess	glucose homeostasis	GPR21 FFAR3 GPR42 LRP1 SLC37A4 ADCY5	6.79e-04	338	65	6	GO:0042593
GeneOntologyBiologicalProcess	carbohydrate homeostasis	GPR21 FFAR3 GPR42 LRP1 SLC37A4 ADCY5	6.89e-04	339	65	6	GO:0033500
GeneOntologyBiologicalProcess	positive regulation of transmission of nerve impulse	FFAR3 GPR42	7.46e-04	13	65	2	GO:0051971
GeneOntologyBiologicalProcess	inorganic anion transmembrane transport	BEST1 CLCNKA CLCNKB SLC37A4	8.48e-04	134	65	4	GO:0098661
GeneOntologyBiologicalProcess	AMPA glutamate receptor clustering	ZDHHC2 SLC7A11	8.68e-04	14	65	2	GO:0097113
GeneOntologyBiologicalProcess	glutamate receptor clustering	ZDHHC2 SLC7A11	8.68e-04	14	65	2	GO:0097688
GeneOntologyBiologicalProcess	chemokine production	FFAR3 GPR42 LRP1 SLC37A4	8.72e-04	135	65	4	GO:0032602
GeneOntologyBiologicalProcess	monoatomic cation transport	SLC17A2 SLC35G1 BEST1 SLC9A4 TRPM5 HTR2A CLCNKB KCNJ10 APLNR SLC5A7 TPCN1	9.05e-04	1157	65	11	GO:0006812
GeneOntologyBiologicalProcess	amine transport	HTR2A FFAR3 GPR42 SLC44A2	9.21e-04	137	65	4	GO:0015837
GeneOntologyBiologicalProcess	regulation of neuronal action potential	FFAR3 GPR42	1.00e-03	15	65	2	GO:0098908
GeneOntologyCellularComponent	apical part of cell	SLC17A2 SLC9A4 CLCNKA KCNJ10 CPO SLC5A7 LRP1 SLC7A11 HYAL2 SLC52A3	1.56e-05	592	66	10	GO:0045177
GeneOntologyCellularComponent	apical plasma membrane	SLC17A2 SLC9A4 CLCNKA KCNJ10 CPO SLC5A7 HYAL2 SLC52A3	1.44e-04	487	66	8	GO:0016324
GeneOntologyCellularComponent	basolateral plasma membrane	ABCC3 BEST1 SLC9A4 CLCNKA KCNJ10 LRP1	5.16e-04	320	66	6	GO:0016323
GeneOntologyCellularComponent	recycling endosome	ZDHHC2 RABEP1 CLN3 TBC1D12 TPCN1	6.82e-04	222	66	5	GO:0055037
GeneOntologyCellularComponent	chloride channel complex	BEST1 CLCNKA CLCNKB	7.79e-04	57	66	3	GO:0034707
GeneOntologyCellularComponent	basal plasma membrane	ABCC3 BEST1 SLC9A4 CLCNKA KCNJ10 LRP1	8.74e-04	354	66	6	GO:0009925
GeneOntologyCellularComponent	membrane microdomain	BEST1 HTR2A CLN3 SLC5A7 TLR6 HYAL2	1.01e-03	364	66	6	GO:0098857
GeneOntologyCellularComponent	basal part of cell	ABCC3 BEST1 SLC9A4 CLCNKA KCNJ10 LRP1	1.22e-03	378	66	6	GO:0045178
GeneOntologyCellularComponent	monoatomic ion channel complex	BEST1 TRPM5 CLCNKA CLCNKB KCNJ10 TPCN1	1.22e-03	378	66	6	GO:0034702
HumanPheno	Hypokalemic metabolic alkalosis	CLCNKA CLCNKB KCNJ10	7.58e-06	9	24	3	HP:0001960
HumanPheno	Hypokalemic alkalosis	CLCNKA CLCNKB KCNJ10	1.97e-05	12	24	3	HP:0001949
HumanPheno	Delayed ability to stand	KIDINS220 CLCNKA CLCNKB	5.99e-05	17	24	3	HP:0025335
HumanPheno	Salt craving	CLCNKB KCNJ10	6.36e-05	3	24	2	HP:0030083
HumanPheno	Hypokalemic hypochloremic metabolic alkalosis	CLCNKA CLCNKB	6.36e-05	3	24	2	HP:0004909
HumanPheno	Abnormal urine sodium concentration	CLCNKA CLCNKB KCNJ10	7.16e-05	18	24	3	HP:0012603
HumanPheno	Metabolic alkalosis	CLCNKA CLCNKB KCNJ10	7.16e-05	18	24	3	HP:0200114
HumanPheno	Abnormal urine potassium concentration	CLCNKA CLCNKB KCNJ10	7.16e-05	18	24	3	HP:0012598
HumanPheno	Increased circulating renin concentration	CLCNKA CLCNKB KCNJ10	8.48e-05	19	24	3	HP:0000848
HumanPheno	Hypochloremic metabolic alkalosis	CLCNKA CLCNKB	1.27e-04	4	24	2	HP:0005977
HumanPheno	Abnormal urine chloride concentration	CLCNKA CLCNKB	2.11e-04	5	24	2	HP:0012600
HumanPheno	Hyperchloriduria	CLCNKA CLCNKB	2.11e-04	5	24	2	HP:0002914
HumanPheno	Abnormal glomerular filtration rate	CLCNKA CLCNKB SLC37A4	3.10e-04	29	24	3	HP:0012212
HumanPheno	Decreased glomerular filtration rate	CLCNKA CLCNKB SLC37A4	3.10e-04	29	24	3	HP:0012213
HumanPheno	Abnormal circulating prostaglandin circulation	CLCNKA CLCNKB	3.15e-04	6	24	2	HP:0011023
HumanPheno	Hyperprostaglandinuria	CLCNKA CLCNKB	3.15e-04	6	24	2	HP:0003527
HumanPheno	Renal potassium wasting	CLCNKB KCNJ10	3.15e-04	6	24	2	HP:0000128
HumanPheno	Alkalosis	CLCNKA CLCNKB KCNJ10	3.43e-04	30	24	3	HP:0001948
HumanPheno	Hypomagnesemia	CLCNKA CLCNKB KCNJ10	3.79e-04	31	24	3	HP:0002917
HumanPheno	Abnormal renal tubular resorption	CLCNKA CLCNKB KCNJ10	4.17e-04	32	24	3	HP:0011038
HumanPheno	Increased circulating aldosterone concentration	CLCNKA CLCNKB KCNJ10	4.17e-04	32	24	3	HP:0000859
HumanPheno	Impaired renal concentrating ability	CLCNKA CLCNKB	4.40e-04	7	24	2	HP:0004727
HumanPheno	Hypochloremia	CLCNKA CLCNKB	4.40e-04	7	24	2	HP:0003113
HumanPheno	Abnormal circulating renin concentration	CLCNKA CLCNKB KCNJ10	4.57e-04	33	24	3	HP:0040084
HumanPheno	Enuresis	CLCNKB KCNJ10 SMARCA2	5.00e-04	34	24	3	HP:0000805
HumanPheno	Abnormal magnesium concentration	CLCNKA CLCNKB KCNJ10	5.00e-04	34	24	3	HP:0004921
HumanPheno	Abnormal circulating unsaturated fatty acid concentration	CLCNKA CLCNKB	5.86e-04	8	24	2	HP:0011022
HumanPheno	Hyperactive renin-angiotensin system	CLCNKA CLCNKB	5.86e-04	8	24	2	HP:0000841
HumanPheno	Abnormal circulating eicosanoid concentration	CLCNKA CLCNKB	5.86e-04	8	24	2	HP:0030361
HumanPheno	Increased urinary potassium	CLCNKA CLCNKB	7.51e-04	9	24	2	HP:0003081
HumanPheno	Impaired renal function	CLCNKA CLCNKB	7.51e-04	9	24	2	HP:0000087
HumanPheno	Renal salt wasting	CLCNKA CLCNKB KCNJ10	7.52e-04	39	24	3	HP:0000127
HumanPheno	Non-Mendelian inheritance	HTR2A CLCNKA CLCNKB NLRP1	8.03e-04	92	24	4	HP:0001426
HumanPheno	Polyuria	CLCNKA CLCNKB KCNJ10	8.10e-04	40	24	3	HP:0000103
HumanPheno	Hypernatriuria	CLCNKA CLCNKB	9.36e-04	10	24	2	HP:0012605
MousePheno	abnormal urine osmolality	CLCNKA CLCNKB MAS1 CLN3 APLNR	4.93e-06	65	54	5	MP:0002987
MousePheno	abnormal urination	CLCNKA CLCNKB MAS1 CLN3 KCNJ10 APLNR	2.16e-05	148	54	6	MP:0001756
MousePheno	abnormal sympathetic neuron innervation pattern	FFAR3 GPR42	4.38e-05	3	54	2	MP:0009284
MousePheno	abnormal digestion	SLC9A4 CEL FFAR3 GPR42 SLC19A3	5.13e-05	105	54	5	MP:0001664
MousePheno	decreased urine osmolality	CLCNKA CLCNKB CLN3 APLNR	5.45e-05	54	54	4	MP:0002988
MousePheno	abnormal sympathetic neuron physiology	FFAR3 GPR42	8.74e-05	4	54	2	MP:0009253
Domain	InaF-motif	INAFM2 INAFM1	1.31e-05	2	68	2	IPR029162
Domain	Cl_channel-K	CLCNKA CLCNKB	1.31e-05	2	68	2	IPR002250
Domain	InaF-motif	INAFM2 INAFM1	1.31e-05	2	68	2	PF15018
Domain	Aquaporin_12	AQP12A AQP12B	1.31e-05	2	68	2	IPR023265
Domain	Aquaporin_11/12	AQP12A AQP12B	3.91e-05	3	68	2	IPR016697
Domain	GPR40-rel_orph	FFAR3 GPR42	7.80e-05	4	68	2	IPR013312
Domain	Cl-channel_core	CLCNKA CLCNKB	4.63e-04	9	68	2	IPR014743
Domain	-	CLCNKA CLCNKB	4.63e-04	9	68	2	1.10.3080.10
Domain	Voltage_CLC	CLCNKA CLCNKB	4.63e-04	9	68	2	PF00654
Domain	Cl-channel_volt-gated	CLCNKA CLCNKB	4.63e-04	9	68	2	IPR001807
Domain	7tm_1	OR8K1 HTR2A GPR21 MAS1 FFAR3 GPR42 MCHR2 APLNR OR9G9	7.47e-04	677	68	9	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR8K1 HTR2A GPR21 MAS1 FFAR3 GPR42 MCHR2 APLNR OR9G9	8.11e-04	685	68	9	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR8K1 HTR2A GPR21 MAS1 FFAR3 GPR42 MCHR2 APLNR OR9G9	8.63e-04	691	68	9	PS50262
Domain	GPCR_Rhodpsn	OR8K1 HTR2A GPR21 MAS1 FFAR3 GPR42 MCHR2 APLNR OR9G9	8.72e-04	692	68	9	IPR000276
Domain	MIP	AQP12A AQP12B	1.16e-03	14	68	2	PS00221
Domain	MIP	AQP12A AQP12B	1.16e-03	14	68	2	PF00230
Domain	MIP	AQP12A AQP12B	1.33e-03	15	68	2	IPR000425
Domain	-	AQP12A AQP12B	1.33e-03	15	68	2	1.20.1080.10
Domain	Aquaporin-like	AQP12A AQP12B	1.33e-03	15	68	2	IPR023271
Domain	MFS_dom	SLC17A2 CLN3 SLC19A3 SLC37A4	1.45e-03	134	68	4	IPR020846
Domain	CBS	CLCNKA CLCNKB	1.52e-03	16	68	2	SM00116
Domain	Zn_pept	CPO CPB1	1.92e-03	18	68	2	SM00631
Domain	CARBOXYPEPT_ZN_2	CPO CPB1	2.15e-03	19	68	2	PS00133
Domain	CBS_dom	CLCNKA CLCNKB	2.38e-03	20	68	2	IPR000644
Domain	CBS	CLCNKA CLCNKB	2.38e-03	20	68	2	PF00571
Domain	CBS	CLCNKA CLCNKB	2.38e-03	20	68	2	PS51371
Domain	CARBOXYPEPT_ZN_1	CPO CPB1	2.38e-03	20	68	2	PS00132
Domain	GPCR_Rhodpsn_7TM	OR8K1 HTR2A GPR21 MAS1 FFAR3 MCHR2 APLNR OR9G9	2.92e-03	670	68	8	IPR017452
Domain	Peptidase_M14	CPO CPB1	3.15e-03	23	68	2	PF00246
Domain	Peptidase_M14	CPO CPB1	3.15e-03	23	68	2	IPR000834
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	ABCC3 BEST1 SLC9A4 AQP12A TRPM5 CLCNKA CLCNKB CLN3 SLC44A2 SLC5A7 SLC7A11 AQP12B TPCN1	1.23e-06	681	54	13	MM14985
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	ABCC3 BEST1 SLC9A4 AQP12A TRPM5 CLCNKA CLCNKB CLN3 SLC44A2 SLC5A7 SLC7A11 ADCY5 TPCN1	2.92e-06	736	54	13	M27287
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	BEST1 TRPM5 CLCNKA CLCNKB TPCN1	3.72e-05	99	54	5	MM14910
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	BEST1 TRPM5 CLCNKA CLCNKB TPCN1	5.16e-05	106	54	5	M27200
Pubmed	Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.	FFAR3 GPR42	3.77e-06	2	68	2	25637492
Pubmed	Cloning, tissue distribution, and intrarenal localization of ClC chloride channels in human kidney.	CLCNKA CLCNKB	3.77e-06	2	68	2	8544406
Pubmed	Selective tracking of FFAR3-expressing neurons supports receptor coupling to N-type calcium channels in mouse sympathetic neurons.	FFAR3 GPR42	3.77e-06	2	68	2	30478340
Pubmed	3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41.	FFAR3 GPR42	3.77e-06	2	68	2	38040866
Pubmed	Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APPswe Alzheimer's Disease Mouse Model.	FFAR3 GPR42	3.77e-06	2	68	2	35408893
Pubmed	FFAR3 modulates insulin secretion and global gene expression in mouse islets.	FFAR3 GPR42	3.77e-06	2	68	2	26091414
Pubmed	The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron.	CLCNKA CLCNKB	3.77e-06	2	68	2	27335120
Pubmed	Assignment of the genes encoding the human chloride channels, CLCNKA and CLCNKB, to 1p36 and of CLCN3 to 4q32-q33 by in situ hybridization.	CLCNKA CLCNKB	3.77e-06	2	68	2	8812470
Pubmed	GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states.	FFAR3 GPR42	3.77e-06	2	68	2	27550964
Pubmed	Associations between CLCNKA_B tag SNPs with essential hypertension and interactions between genetic and environmental factors in an island population in China.	CLCNKA CLCNKB	3.77e-06	2	68	2	25919862
Pubmed	Intestinal FFA3 mediates obesogenic effects in mice on a Western diet.	FFAR3 GPR42	3.77e-06	2	68	2	35858247
Pubmed	Targeting kidney CLC-K channels: pharmacological profile in a human cell line versus Xenopus oocytes.	CLCNKA CLCNKB	3.77e-06	2	68	2	24863058
Pubmed	Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel.	CLCNKA CLCNKB	3.77e-06	2	68	2	9916798
Pubmed	Kidney kinetics and chloride ion pumps.	CLCNKA CLCNKB	3.77e-06	2	68	2	9916791
Pubmed	Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.	FFAR3 GPR42	3.77e-06	2	68	2	22506074
Pubmed	Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress.	FFAR3 GPR42	3.77e-06	2	68	2	32073900
Pubmed	The effects of propionate and valerate on insulin responsiveness for glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes via G protein-coupled receptor 41.	FFAR3 GPR42	3.77e-06	2	68	2	24748202
Pubmed	The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity.	FFAR3 GPR42	3.77e-06	2	68	2	36362376
Pubmed	Expanding Genotype-Phenotype Correlation of CLCNKA and CLCNKB Variants Linked to Hearing Loss.	CLCNKA CLCNKB	3.77e-06	2	68	2	38069401
Pubmed	Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells.	AQP12A AQP12B	3.77e-06	2	68	2	15809071
Pubmed	Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.	FFAR3 GPR42	3.77e-06	2	68	2	20399779
Pubmed	Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42.	FFAR3 GPR42	3.77e-06	2	68	2	19630535
Pubmed	A regulatory calcium-binding site at the subunit interface of CLC-K kidney chloride channels.	CLCNKA CLCNKB	3.77e-06	2	68	2	20805576
Pubmed	Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content.	FFAR3 GPR42	3.77e-06	2	68	2	23110765
Pubmed	The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation.	FFAR3 GPR42	3.77e-06	2	68	2	26522986
Pubmed	Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis.	AQP12A AQP12B	3.77e-06	2	68	2	19726746
Pubmed	Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.	FFAR3 GPR42	3.77e-06	2	68	2	14722361
Pubmed	Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41.	FFAR3 GPR42	3.77e-06	2	68	2	27664183
Pubmed	Genetic analysis of the aquaporin water channels AQP12A and AQP12B in patients with chronic pancreatitis.	AQP12A AQP12B	3.77e-06	2	68	2	36167651
Pubmed	Salt wasting and deafness resulting from mutations in two chloride channels.	CLCNKA CLCNKB	3.77e-06	2	68	2	15044642
Pubmed	Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.	FFAR3 GPR42	3.77e-06	2	68	2	26260360
Pubmed	G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation.	FFAR3 GPR42	3.77e-06	2	68	2	37019194
Pubmed	Two highly homologous members of the ClC chloride channel family in both rat and human kidney.	CLCNKA CLCNKB	3.77e-06	2	68	2	8041726
Pubmed	A cytoplasmic domain mutation in ClC-Kb affects long-distance communication across the membrane.	CLCNKA CLCNKB	3.77e-06	2	68	2	18648499
Pubmed	Cl(-) channels in basolateral TAL membranes XV. Molecular heterogeneity between cortical and medullary channels.	CLCNKA CLCNKB	3.77e-06	2	68	2	11014860
Pubmed	Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation.	FFAR3 GPR42	1.13e-05	3	68	2	22673524
Pubmed	Human CLC-K Channels Require Palmitoylation of Their Accessory Subunit Barttin to Be Functional.	CLCNKA CLCNKB	1.13e-05	3	68	2	26013830
Pubmed	Barttin increases surface expression and changes current properties of ClC-K channels.	CLCNKA CLCNKB	1.13e-05	3	68	2	12111250
Pubmed	The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.	FFAR3 GPR42	1.13e-05	3	68	2	12496283
Pubmed	Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.	FFAR3 GPR42	1.13e-05	3	68	2	23665276
Pubmed	Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension.	CLCNKA CLCNKB	1.13e-05	3	68	2	17510212
Pubmed	Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer.	FFAR3 GPR42	1.13e-05	3	68	2	34210970
Pubmed	Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3.	FFAR3 GPR42	1.13e-05	3	68	2	31719611
Pubmed	Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43.	FFAR3 GPR42	1.13e-05	3	68	2	16123168
Pubmed	GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.	FFAR3 GPR42	1.13e-05	3	68	2	22493486
Pubmed	Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.	FFAR3 GPR42	1.13e-05	3	68	2	23066016
Pubmed	Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.	FFAR3 GPR42	1.13e-05	3	68	2	25581519
Pubmed	Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion.	CLCNKA CLCNKB	1.13e-05	3	68	2	11734858
Pubmed	Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.	FFAR3 GPR42	1.13e-05	3	68	2	22190648
Pubmed	Barttin modulates trafficking and function of ClC-K channels.	CLCNKA CLCNKB	1.13e-05	3	68	2	16849430
Pubmed	Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.	FFAR3 GPR42	1.13e-05	3	68	2	31272808
Pubmed	GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.	FFAR3 GPR42	1.13e-05	3	68	2	23885020
Pubmed	Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.	FFAR3 GPR42	1.13e-05	3	68	2	29768180
Pubmed	Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.	FFAR3 GPR42	1.13e-05	3	68	2	18931303
Pubmed	GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex virus type 1 infection.	FFAR3 GPR42	1.13e-05	3	68	2	38524121
Pubmed	Mechanisms of Disease: the kidney-specific chloride channels ClCKA and ClCKB, the Barttin subunit, and their clinical relevance.	CLCNKA CLCNKB	1.13e-05	3	68	2	18094726
Pubmed	Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Krüppel-like factor, a novel zinc finger repressor.	CLCNKA CLCNKB	1.13e-05	3	68	2	10982849
Pubmed	Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function.	FFAR3 GPR42	1.13e-05	3	68	2	38329121
Pubmed	Haplotype diversity in four genes (CLCNKA, CLCNKB, BSND, NEDD4L) involved in renal salt reabsorption.	CLCNKA CLCNKB	2.25e-05	4	68	2	17652939
Pubmed	Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.	FFAR3 GPR42	2.25e-05	4	68	2	23401498
Pubmed	A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.	FFAR3 GPR42	2.25e-05	4	68	2	9344866
Pubmed	Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).	FFAR3 GPR42	2.25e-05	4	68	2	21518883
Pubmed	A family of fatty acid binding receptors.	FFAR3 GPR42	2.25e-05	4	68	2	15684720
Pubmed	Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice.	FFAR3 GPR42	2.25e-05	4	68	2	29021375
Pubmed	Microbial metabolites, short-chain fatty acids, restrain tissue bacterial load, chronic inflammation, and associated cancer in the colon of mice.	FFAR3 GPR42	2.25e-05	4	68	2	29644622
Pubmed	GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.	TRPM5 TPCN1	3.75e-05	5	68	2	26571400
Pubmed	Fatty acid binding receptors and their physiological role in type 2 diabetes.	FFAR3 GPR42	3.75e-05	5	68	2	19009545
Pubmed	Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.	FFAR3 GPR42	3.75e-05	5	68	2	24327954
Pubmed	Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81.	FFAR3 GPR42	3.75e-05	5	68	2	19047060
Pubmed	TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse model of MDS.	NUP98 TLR6	5.62e-05	6	68	2	32652111
Pubmed	Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis.	FFAR3 GPR42	5.62e-05	6	68	2	19460454
Pubmed	Impairment in renal medulla development underlies salt wasting in Clc-k2 channel deficiency.	CLCNKA CLCNKB	7.86e-05	7	68	2	34499620
Pubmed	The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis.	MARCHF6 SLC7A11	7.86e-05	7	68	2	35941365
Pubmed	Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney.	CLCNKA CLCNKB	7.86e-05	7	68	2	11423561
Pubmed	Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.	FFAR3 GPR42	1.05e-04	8	68	2	34626852
Pubmed	Changing expression of chloride channels during preimplantation mouse development.	CLCNKA CLCNKB	1.34e-04	9	68	2	23115349
Pubmed	Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways.	NCKAP1 NLRP1	3.38e-04	14	68	2	15749123
Pubmed	Microbiota modulate sympathetic neurons via a gut-brain circuit.	FFAR3 GPR42	3.89e-04	15	68	2	32641826
Pubmed	Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal Gland Cells.	AQP12A AQP12B	3.89e-04	15	68	2	34540996
Pubmed	Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance.	AQP12A AQP12B	5.03e-04	17	68	2	26847765
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	ABCC3 FRAS1 DIPK1A MARCHF6 LRP1 SEC63 SLC7A11 SLC37A4 TPCN1	5.36e-04	1201	68	9	35696571
Pubmed	Expression patterns of the aquaporin gene family during renal development: influence of genetic variability.	AQP12A AQP12B	6.30e-04	19	68	2	19367412
Pubmed	Analysis of the asymmetrically expressed Ablim1 locus reveals existence of a lateral plate Nodal-independent left sided signal and an early, left-right independent role for nodal flow.	APLNR HYAL2	7.00e-04	20	68	2	20487527
Pubmed	Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.	HTR2A CA8	8.48e-04	22	68	2	21348951
Pubmed	Stable association between G alpha(q) and phospholipase C beta 1 in living cells.	HTR2A FFAR3 MCHR2	8.70e-04	95	68	3	16754659
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	NCKAP1 MARCHF6 TBC1D12	1.16e-03	105	68	3	9628581
Pubmed	Discovery and validation of genes driving drug-intake and related behavioral traits in mice.	BTG2 ELOF1	1.91e-03	33	68	2	38164795
Interaction	TXNDC15 interactions	SLC17A2 KIDINS220 GPR21 DIPK1A MARCHF6	1.55e-06	64	62	5	int:TXNDC15
Interaction	YIPF1 interactions	SLC35G1 YIPF1 FFAR3 GPR42	1.01e-05	44	62	4	int:YIPF1
Cytoband	10q23.33	SLC35G1 TBC1D12	5.36e-04	23	68	2	10q23.33
Cytoband	4p14	NWD2 TLR6	1.79e-03	42	68	2	4p14
Cytoband	1p36	CLCNKA CLCNKB	2.24e-03	47	68	2	1p36
Cytoband	17p13.2	RABEP1 NLRP1	3.05e-03	55	68	2	17p13.2
Cytoband	19q13.1	FFAR3 GPR42	3.05e-03	55	68	2	19q13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr4p14	NWD2 TLR6	4.49e-03	67	68	2	chr4p14
GeneFamily	Solute carriers	SLC17A2 SLC35G1 SLC9A4 SLC19A3 SLC44A2 SLC5A7 SLC7A11 SLC37A4 SLC52A3	8.17e-07	395	48	9	752
GeneFamily	Chloride voltage-gated channels	CLCNKA CLCNKB	3.06e-04	10	48	2	302
GeneFamily	Aquaporins	AQP12A AQP12B	6.15e-04	14	48	2	305
GeneFamily	G protein-coupled receptors, Class A orphans	GPR21 MAS1 GPR42	1.16e-03	78	48	3	262
GeneFamily	Carboxypeptidases	CPO CPB1	1.40e-03	21	48	2	1321
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-AT1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	FUT10 CEL CLCNKA CLCNKB MAS1 ADCY5	4.77e-07	197	66	6	f7ef62d78336812573148f8bfce401877ec4e29c
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CEL CLCNKB KCNJ10 CPO SLC19A3	3.54e-06	156	66	5	4d2679e7639758c49fc25a2deb9109b08f0a3e57
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AQP12A CEL CPB1 SLC7A11	3.60e-06	70	66	4	26178ee967d647224d93c7a6380f2d15d8fcfb8f
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SLC35G1 NWD2 LRP1 WDR17 ADCY5	5.39e-06	170	66	5	5570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZDHHC2 SLC7A6OS NXPH1 SLC5A7 CA8	5.86e-06	173	66	5	2b448acd5e584f24567204c31b8d74715e92f32a
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZDHHC2 SLC7A6OS NXPH1 SLC5A7 CA8	5.86e-06	173	66	5	5086edc29c5a6137ca09877929a1317f9739c801
ToppCell	BAL-Mild-Epithelial-Epithelial-AT1/AT2\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NDST3 CEL CLCNKA CLCNKB ADCY5	6.03e-06	174	66	5	b7f5492ce8098f7eb0aef30ee558d00738d59d0e
ToppCell	BAL-Mild-Epithelial-Epithelial-AT1/AT2-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NDST3 CEL CLCNKA CLCNKB ADCY5	6.03e-06	174	66	5	71730503be3d9c839c4c9e950145e2101d682a1c
ToppCell	BAL-Mild-Epithelial-Epithelial-AT1/AT2\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	NDST3 CEL CLCNKA CLCNKB ADCY5	6.03e-06	174	66	5	ee8ac51fa0b426ad7b7453371bb79c8bf8c1d358
ToppCell	BAL-Mild-Epithelial-Epithelial-AT1/AT2-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NDST3 CEL CLCNKA CLCNKB ADCY5	6.03e-06	174	66	5	cafe4d6b5f08d8888e9db6e196c66df991c03e7b
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FRAS1 NWD2 NCKAP1 MAS1 TMEM121B	6.20e-06	175	66	5	ff0789f5913c9f3c49159e40b1ec3d2ff175ec9f
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	FRAS1 NWD2 NCKAP1 MAS1 TMEM121B	6.20e-06	175	66	5	21f8f11a8b874d4f7c47931010a2535f2a5a3373
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCC3 FRAS1 NWD2 GPR21 MCHR2	6.92e-06	179	66	5	820289f14ecf165758529c236bb220bb1a744f02
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCC3 FRAS1 NWD2 GPR21 MCHR2	6.92e-06	179	66	5	e5f781d35449628a7f356d71e26231dd63482eec
ToppCell	COVID-19-kidney-DCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FRAS1 CLCNKA CLCNKB KCNJ10 SLC19A3	8.78e-06	188	66	5	1d56cd409793f05cca20757ab26e91f1a1ee67b5
ToppCell	renal_cortex_nuclei-Adult_normal_reference\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 BTG2 CLCNKB TPCN1 CA8	9.01e-06	189	66	5	a48df46274d51e84ffb40264646de7346104efb9
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CEL CLCNKA CLCNKB KCNJ10 SLC19A3	9.72e-06	192	66	5	46ea8f4f292db70420b378c6fa3e55e99413679c
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CEL CLCNKA CLCNKB KCNJ10 SLC19A3	9.97e-06	193	66	5	dd9874898587fe9fd9cf2aebc2e0579dcf06944e
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A4 CEL CLCNKA CLCNKB SLC52A3	9.97e-06	193	66	5	46d5d1f8150ebbc7f1941b96ab184491e5c1210b
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 SLC9A4 BTG2 CLCNKB SLC52A3	9.97e-06	193	66	5	d994b2f2707877288f88cab7cd6002ef91962c50
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CEL CLCNKA CLCNKB KCNJ10 SLC19A3	1.02e-05	194	66	5	f08a7618a9ccf12e4a7620235ae662a8abc521af
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CEL CLCNKA CLCNKB KCNJ10 SLC19A3	1.05e-05	195	66	5	60d08fb27469d1e247bc47b651d7023ba82cf92f
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A4 CEL CLCNKA CLCNKB SLC52A3	1.05e-05	195	66	5	3f517c6fc372bdcaf45b3af373414f13cbebd4ba
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CEL CLCNKA CLCNKB KCNJ10 SLC19A3	1.07e-05	196	66	5	f40d10ea7714067585493fdc89744714aa427de8
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CEL CLCNKA CLCNKB KCNJ10 SLC19A3	1.07e-05	196	66	5	b8350340d86e4524e9616a427e7f2e116a6fb3be
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Transitional_AT2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	NDST3 CEL CLCNKA CLCNKB ADCY5	1.16e-05	199	66	5	cd581d7330b471431ef427f8a4f5be553f70e068
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AQP12A CEL CPB1 SLC7A11	1.87e-05	106	66	4	3aa55c3db4e4abd39c8f2f89f2516927d94ad9d7
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AQP12A CEL CPB1 SLC7A11	1.87e-05	106	66	4	c890c838785dfeda30f3b563194da9cfb49b157a
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_B\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	ZDHHC2 FUT10 APLNR ADCY5	3.36e-05	123	66	4	e0130010aa406d4e9d8f16ad32858c382277eeb2
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRAS1 SLC5A7 CA8 SLC52A3	6.05e-05	143	66	4	28e936c298a45f88d14f0146caf3d5a22d483cd5
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-4\|TCGA-Brain / Sample_Type by Project: Shred V9	NWD2 GPR21 MAS1 MCHR2	7.10e-05	149	66	4	ff472ad641efd655905e99a9a4cacd5245ab8854
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZDHHC2 NDST3 FUT10 APLNR	8.48e-05	156	66	4	1928c86deb3bcd01db4ae76919a351066aadb39a
ToppCell	IPF-Epithelial-Ionocyte\|Epithelial / Disease state, Lineage and Cell class	CEL CLCNKA CLCNKB ADCY5	8.91e-05	158	66	4	67adf625a959444762d32268b3b7441f6f8b3b8c
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ABCC3 FRAS1 KCNJ10 SLC5A7	8.91e-05	158	66	4	d78e7e52657dc094430291fec07e9c298be9e584
ToppCell	IPF-Epithelial-Ionocyte\|IPF / Disease state, Lineage and Cell class	CEL CLCNKA CLCNKB ADCY5	9.35e-05	160	66	4	d65d19f4fae60836bfd4303a1bb7de34e9d83e35
ToppCell	IPF-Epithelial-Ionocyte\|World / Disease state, Lineage and Cell class	CEL CLCNKA CLCNKB ADCY5	9.58e-05	161	66	4	f1cd5c938cdc08ad8995371b72493850a6cf277a
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NWD2 SLC19A3 LRP1 CPB1	9.58e-05	161	66	4	a006491c991e6a134be20ad75092a91f3b7c3c91
ToppCell	3'-Distal_airway-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEL CLCNKA CLCNKB ADCY5	9.81e-05	162	66	4	9a18286e361e1dd18e6f943ce27db58b199fb6e4
ToppCell	TCGA-Kidney-Solid_Tissue_Normal-Kidney-Kidney_normal_tissue\|TCGA-Kidney / Sample_Type by Project: Shred V9	NDST3 SLC9A4 CLCNKA KCNJ10	9.81e-05	162	66	4	a0367e9af78e4699b9d89d3e0597589e644f844c
ToppCell	3'-Distal_airway-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEL CLCNKA CLCNKB ADCY5	9.81e-05	162	66	4	3395e4dffdb9304d157c325e1fc0f12b433c7bd3
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	NCKAP1 TMEM121B FFAR3 GPR42	9.81e-05	162	66	4	2259e9536147e9cdee772e3a30ba7d104573262c
ToppCell	TCGA-Kidney-Solid_Tissue_Normal-Kidney\|TCGA-Kidney / Sample_Type by Project: Shred V9	NDST3 SLC9A4 CLCNKA KCNJ10	9.81e-05	162	66	4	d007ec42d6458431f6c490df61de7a9caef857f0
ToppCell	3'-Distal_airway-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEL CLCNKA CLCNKB ADCY5	9.81e-05	162	66	4	9522af31f6b2f3cb81b6b84bd08353eea504d1d6
ToppCell	TCGA-Kidney-Solid_Tissue_Normal\|TCGA-Kidney / Sample_Type by Project: Shred V9	NDST3 SLC9A4 CLCNKA KCNJ10	9.81e-05	162	66	4	65549ffdbfe8619693345db78e6ddbdde7b742c9
ToppCell	3'-Distal_airway-Epithelial-Neuro-endocrine/ionocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEL CLCNKA CLCNKB ADCY5	9.81e-05	162	66	4	40265af9b36fd144a8577b8dacccd4fc0888a593
ToppCell	control-Epithelial-Ionocyte\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CEL CLCNKA CLCNKB ADCY5	1.05e-04	165	66	4	5cfba9a46bd8ceeca74a6493057b4d38af6b06fe
ToppCell	NS-control-d_0-4-Epithelial-Ionocyte\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CEL CLCNKA CLCNKB ADCY5	1.08e-04	166	66	4	6d9fb239f69ba519844f593c00d515e1aac4ff50
ToppCell	control-Epithelial-Ionocyte\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CEL CLCNKA CLCNKB ADCY5	1.13e-04	168	66	4	327b02f19f4a8607c033203824fdc60a1254331f
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	SLC9A4 NCKAP1 MAS1 TMEM121B	1.13e-04	168	66	4	6db453cbbbaf4144a86fadcfa5805d33396713b5
ToppCell	NS-critical-d_16-33-Epithelial-Ionocyte\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CEL CLCNKA CLCNKB ADCY5	1.13e-04	168	66	4	6a233045638cb83dab64789b996b7598c325001e
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_IL7R\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCC3 FRAS1 NWD2 MCHR2	1.18e-04	170	66	4	6af7dee9b8298d4499e05a82cf9cdfe3bd81d384
ToppCell	Ionocyte\|World / Class top	KIDINS220 CEL CLCNKB ADCY5	1.18e-04	170	66	4	d2e592f2a679e6a8d32f2b752d9a3c493e50ced4
ToppCell	BL-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CEL CLCNKA CLCNKB ADCY5	1.18e-04	170	66	4	b465df2dac6b4e98b4ede6ad0c6347656757885c
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM5 FFAR3 SLC19A3 ADCY5	1.18e-04	170	66	4	17bd7fd25a2657cb536ad47e294332920f759e95
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AQP12A CEL CPB1 SLC7A11	1.26e-04	173	66	4	c62e3ffed55bbb00dcaef6da0aab8446f3f55085
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CLCNKA CLCNKB KCNJ10 SLC19A3	1.26e-04	173	66	4	0c74bdb40e635d906fd180412c23bf7fed61621e
ToppCell	Ionocyte-iono-2\|World / Class top	KIDINS220 CEL CLCNKB ADCY5	1.26e-04	173	66	4	e5ec28ccc5e048fd98de4c876e5c53b866b66228
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AQP12A CEL CPB1 SLC7A11	1.26e-04	173	66	4	f612d4ea9ab8dcde475f4118bca3e49be786e7fa
ToppCell	Bronchial_Brush-Epithelial-Ionocytes\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	CEL CLCNKA CLCNKB ADCY5	1.26e-04	173	66	4	e1de849dcd96063136bdac87e050ddbd55cabdcc
ToppCell	Bronchial_Brush-Epithelial-Ionocytes\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	CEL CLCNKA CLCNKB ADCY5	1.26e-04	173	66	4	f2a8f4918c1fb68d98bc3f33cd624de0f0f11e06
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AQP12A CEL CPB1 SLC7A11	1.29e-04	174	66	4	165e14cad57e90aa247dcecfaa3c2e8ff2a470ad
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AQP12A CEL CPB1 SLC7A11	1.29e-04	174	66	4	4289dfc7613db4bb3d706b9b65d06e84c0c53558
ToppCell	Bronchial_Biopsy-Epithelial-Ionocytes\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	CEL CLCNKA CLCNKB ADCY5	1.29e-04	174	66	4	7e7b13de916cd4fa0fa6fb06e6b4942877afa9fb
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AQP12A CEL CPB1 SLC7A11	1.32e-04	175	66	4	3f1b2e23fec953148fb0711e523c463adb07dca4
ToppCell	Bronchial_Biopsy-Epithelial-Ionocytes\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	CEL CLCNKA CLCNKB ADCY5	1.32e-04	175	66	4	13b8f7dc38c90b74d4a20a84a8705d8e2ec244f6
ToppCell	NS-moderate-d_0-4-Epithelial-Ionocyte\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CEL CLCNKA CLCNKB ADCY5	1.32e-04	175	66	4	a1e0a15c69211d6db2edeb101476f0f6e08b90c8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 CLCNKA CLCNKB KCNJ10	1.32e-04	175	66	4	787ac1a12cda10af5c8830471702a4cbaf43e79e
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EARS2 CLN3 LRP1 SLC7A11	1.35e-04	176	66	4	450c25ec5eeb65425f904e0a25aaafdf5682ef9c
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCC3 FRAS1 NWD2 MCHR2	1.35e-04	176	66	4	03d194c9814e12802cd932afade69e868814cb78
ToppCell	3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEL CLCNKA CLCNKB ADCY5	1.38e-04	177	66	4	6d89042bda8e244babb68929e84b25edcb545a77
ToppCell	3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEL CLCNKA CLCNKB ADCY5	1.38e-04	177	66	4	daaccf1249dcf816df4caca695a944f53078291a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Degenerative_Distal_Convoluted_Tubule_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CLCNKA CLCNKB KCNJ10 SLC19A3	1.38e-04	177	66	4	dc846d0feb94d4c289553cc3ac9dac81d10409cb
ToppCell	3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEL CLCNKA CLCNKB ADCY5	1.38e-04	177	66	4	338bdda26796bf4e16072878c070212d1006cf57
ToppCell	NS-moderate-d_07-13-Epithelial-Ionocyte\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CEL CLCNKA CLCNKB ADCY5	1.38e-04	177	66	4	99500aed584f793aaf308f8afbf5d1c6a9b4ee55
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9A4 CEL CLCNKB KCNJ10	1.38e-04	177	66	4	c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCell	3'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEL CLCNKA CLCNKB ADCY5	1.38e-04	177	66	4	c5a16f984c836dbf7d0faf061677844167ab612a
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCC3 FRAS1 NWD2 MCHR2	1.41e-04	178	66	4	a62137d7f5fac16619f8a02844cdb0be7a794bf2
ToppCell	facs-Pancreas-Exocrine-18m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AQP12A CEL CPB1 SLC7A11	1.44e-04	179	66	4	bbfbfb32773346080127055b5aafa36bbf7d0942
ToppCell	NS-critical-LOC-Epithelial-Ionocyte\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CEL CLCNKA CLCNKB ADCY5	1.44e-04	179	66	4	65a96bee7bc28f5bfc20f0fd92bcc0ab2eb5e06c
ToppCell	NS-moderate-d_16-33-Epithelial-Ionocyte\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CEL CLCNKA CLCNKB ADCY5	1.47e-04	180	66	4	8af8b4af2dc72223ac71fc027e0d4280c5dd81f8
ToppCell	5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEL CLCNKA CLCNKB ADCY5	1.47e-04	180	66	4	5286e66ff6b7154390b3e9c189704a71d56bc89c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CLCNKA CLCNKB KCNJ10 ADCY5	1.47e-04	180	66	4	eee71184ebed2694d3e60f579a44b3cf7dd2cd35
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CLCNKA CLCNKB KCNJ10 ADCY5	1.47e-04	180	66	4	a17dbe03597b81e7a1fe2bf2d23e59e55c615a2a
ToppCell	5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEL CLCNKA CLCNKB ADCY5	1.47e-04	180	66	4	2b6b295b5c21b829828afae9ab4c3eb9233f6f45
ToppCell	5'-Parenchyma_lung-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEL CLCNKA CLCNKB ADCY5	1.47e-04	180	66	4	bf587387145a2b5e83766fbccf76eecc6d5e8241
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCC3 FRAS1 NWD2 MCHR2	1.50e-04	181	66	4	13270b6ba6a9c8e5681c6f40000c643ce1d9344a
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEL CLCNKA CLCNKB ADCY5	1.50e-04	181	66	4	40df0afcb6848202da54670e84f22d7c3a515d01
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEL CLCNKA CLCNKB ADCY5	1.50e-04	181	66	4	2b53a65ca5616a7b9f64232c3e0b7212d1e2f063
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_IL7R\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ABCC3 FRAS1 NWD2 MCHR2	1.50e-04	181	66	4	3e3c903b522dced6bec5dc447cc3f8bf9a9749e3
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEL CLCNKA CLCNKB ADCY5	1.50e-04	181	66	4	6aef84616e8d2faf54b7e9e6cd02f33c3066dabc
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR21 SMARCA2 CA8 SLC52A3	1.50e-04	181	66	4	4ea02344e1996f264dd5e14f3b19c8782ce41699
ToppCell	5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEL CLCNKA CLCNKB ADCY5	1.50e-04	181	66	4	40d3829ae4aaf81e8616c3499ff8933137fc1cc4
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC35G1 SLC9A4 CLCNKB KCNJ10	1.54e-04	182	66	4	2ef6889321fd0104d277518d130e19143b3af41c
ToppCell	cellseq-Epithelial-Epithelial_Neuro-Secretory-Ionocyte\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CEL CLCNKA CLCNKB ADCY5	1.54e-04	182	66	4	6e7dac78dc030f74e546b9f6db07556e9bb13ac2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 SLC9A4 TRPM5 SLC5A7	1.54e-04	182	66	4	f96095b81188b52db8fcfca4837129cfcd9bd7b7
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDST3 NWD2 HTR2A MCHR2	1.54e-04	182	66	4	14a117c5e50db31ee1b2cf4df4d133451fd6d55f
ToppCell	facs-Kidney-nan-24m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEL CLCNKA CLCNKB CPB1	1.54e-04	182	66	4	b8be66a867ea1bbae0820b26dbd55b68611f5ad5
ToppCell	cellseq-Epithelial-Epithelial_Neuro-Secretory-Ionocyte-Ionocyte\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CEL CLCNKA CLCNKB ADCY5	1.54e-04	182	66	4	cd972d30519db706477c6b0c901165b81b74abed
ToppCell	facs-Kidney-nan-24m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEL CLCNKA CLCNKB CPB1	1.54e-04	182	66	4	cb488f9a9b200e2557335ccf22535cd247512cdc
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CEL CLCNKA CLCNKB KCNJ10	1.57e-04	183	66	4	2f0ee40e69ad1259e56e8ee4b352736900eb8901
Disease	Bartter disease type 4B	CLCNKA CLCNKB	5.23e-06	2	68	2	cv:C4310805
Disease	BARTTER SYNDROME, TYPE 4B	CLCNKA CLCNKB	5.23e-06	2	68	2	C2751312
Disease	BARTTER SYNDROME, TYPE 4B, NEONATAL, WITH SENSORINEURAL DEAFNESS	CLCNKA CLCNKB	5.23e-06	2	68	2	C4310805
Disease	Bartter disease type 3 (implicated_via_orthology)	CLCNKA CLCNKB	5.23e-06	2	68	2	DOID:0110144 (implicated_via_orthology)
Disease	Bartter disease type 4b (is_implicated_in)	CLCNKA CLCNKB	5.23e-06	2	68	2	DOID:0110146 (is_implicated_in)
Disease	BARTTER SYNDROME, TYPE 4B, NEONATAL, WITH SENSORINEURAL DEAFNESS	CLCNKA CLCNKB	5.23e-06	2	68	2	613090
Disease	Bartter disease (implicated_via_orthology)	CLCNKA CLCNKB	5.23e-06	2	68	2	DOID:445 (implicated_via_orthology)
Disease	Bartter syndrome	CLCNKA CLCNKB	7.80e-05	6	68	2	cv:C0004775
Disease	Abdominal Migraine	HTR2A LRP1	1.86e-04	9	68	2	C0270858
Disease	Sick Headaches	HTR2A LRP1	1.86e-04	9	68	2	C0700438
Disease	Acute Confusional Migraine	HTR2A LRP1	1.86e-04	9	68	2	C0521664
Disease	Status Migrainosus	HTR2A LRP1	1.86e-04	9	68	2	C0338489
Disease	Cervical Migraine Syndrome	HTR2A LRP1	1.86e-04	9	68	2	C0007852
Disease	Hemicrania migraine	HTR2A LRP1	1.86e-04	9	68	2	C0018984
Disease	nephrogenic diabetes insipidus (implicated_via_orthology)	CLCNKA CLCNKB	2.33e-04	10	68	2	DOID:12387 (implicated_via_orthology)
Disease	Lenticulostriate Disorders	HTR2A SLC19A3	3.40e-04	12	68	2	C0750951
Disease	survival time, lung adenocarcinoma	NWD2 NXPH1	3.40e-04	12	68	2	EFO_0000571, EFO_0000714
Disease	Extrapyramidal Disorders	HTR2A SLC19A3	3.40e-04	12	68	2	C0015371
Disease	Oligospermia	PIWIL3 TPCN1	3.40e-04	12	68	2	C0028960
Disease	Basal Ganglia Diseases	HTR2A SLC19A3	3.40e-04	12	68	2	C0004782
Disease	Migraine Disorders	HTR2A LRP1	4.02e-04	13	68	2	C0149931
Disease	phosphatidylcholine 38:6 measurement	ABCC3 CPO	6.15e-04	16	68	2	EFO_0010388
Disease	Dystonia	EARS2 SLC19A3 ADCY5	1.04e-03	86	68	3	C0013421
Disease	bowel opening frequency	FFAR3 GPR42	2.18e-03	30	68	2	EFO_0600084
Disease	large artery stroke	SLC17A2 CEL LRP1	2.29e-03	113	68	3	EFO_0005524

Protein segments in the cluster

Peptide	Gene	Start	Entry
YSLTPDIYLIDWIFT	TBC1D12	656	O60347
LLEYVQVYWLGPLTG	AQP12A	216	Q8IXF9
VWIGYLSSAVNPLVY	HTR2A	366	P28223
AYDWISIPLVYTQVV	BEST1	226	O76090
WTVFFIYTIYTLLPV	ADCY5	331	O95622
LLEYVQVYWLGPLTG	AQP12B	216	A6NM10
YWTLTYLALPTVTDQ	CEL	541	P19835
VLPVLNIDGYIYTWT	CPO	146	Q8IVL8
ITYLSEPVDVYSDWI	ELOF1	61	P60002
VTVIDLLYGWPLYQF	NWD2	1081	Q9ULI1
ITILIDPSDRAYSWY	NDST3	691	O95803
YVSPSGYRLVSETEW	RABEP1	501	Q15276
VTLITLWVYVYVDPN	ABCC3	546	O15438
YPYIISNRWLSIGVE	ABCC3	1186	O15438
LTFVVTLPLWATYTY	APLNR	76	P35414
WETSGLVYLDYIRVI	NUP98	1686	P52948
YLTRLLVPYVVNVSW	HYAL2	346	Q12891
SVTGLYSVYPIIWAA	KIDINS220	131	Q9ULH0
VSYIYVTAPRGWASL	FRAS1	3476	Q86XX4
ISVERCLSVLYPIWY	MAS1	126	P04201
VRTSYLPEEILWGYE	KCNJ10	296	P78508
PNGLTLDYVTERIYW	LRP1	3191	Q07954
WPLDETSGIYYTEIR	NLRP1	206	Q9C000
YTLVAFAWLGVVPLT	MARCHF6	96	O60337
WYSSVYTPKILVICI	OR9G9	71	P0C7N8
PLIITSYCYSRLVWI	GPR42	196	O15529
WLVTTVGAYLPAVFE	MVP	196	Q14764
EPTITSLYTNWYLET	NCKAP1	781	Q9Y2A7
PDDVLWYTLYLTITT	MCHR2	191	Q969V1
LLSPYLWVLSTGYLV	SLC37A4	221	O43826
VVPVYYGSPSITDWL	FUT10	301	Q6P4F1
ALLVWTAAYVYVVNP	CCDC188	351	H7C350
LLRDYWVYEGSLTIP	CA8	211	P35219
PLIITSYCYSRLVWI	FFAR3	196	O14843
NYYWVPILTVIVGSY	SLC44A2	636	Q8IWA5
RITSVFYILWLPYII	GPR21	256	Q99679
VEYTSLYGISLPWVI	DIPK1A	231	Q5T7M9
LEIWLGYVTSVLQYE	PIWIL3	261	Q7Z3Z3
ITNEIFPVWTYSYLV	SLC19A3	51	Q9BZV2
PVLNIDGYIYTWTKS	CPB1	216	P15086
ELTVNILTMGYWPTY	CUL4B	676	Q13620
IVLAVYYSLIWQPVG	INAFM2	51	P0DMQ5
LLAVYYGLIWVPTRS	INAFM1	46	C9JVW0
WYLSSDLVYIVIFPQ	SLC5A7	406	Q9GZV3
VCVPSYLELWVFYTV	SMS	346	P52788
EGWYLPSYLTVVIQL	SLC52A3	36	Q9NQ40
YLIIVPLSTLSNWTY	SMARCA2	776	P51531
VYFLTLASPVLWLYE	TMEM121B	431	Q9BXQ6
WYVLFLLQPTVYLVT	NXPH1	6	P58417
YVQIPYEVTLWILLA	SLC9A4	66	Q6AI14
VLWVLVIVPYLYSTF	OR8K1	146	Q8NGG5
IPYLLISGSWDYTIK	WDR17	621	Q8IZU2
LVSPVYSYLWTRPAV	EARS2	416	Q5JPH6
TLWVDPYEVSYRIGE	BTG2	101	P78543
LLWYIVPLVVVYFAE	CLN3	281	Q13286
LRYLSWTVYPVALVS	CLCNKA	91	P51800
LRYLSWTVYPVALVS	CLCNKB	91	P51801
YYLETATPGWIENIL	SLC7A6OS	201	Q96CW6
ITLTGVPAYYLFIIW	SLC7A11	456	Q9UPY5
GYSLFIYIPTAILWI	YIPF1	206	Q9Y548
GPEVTLYFWVFTLVL	TRPM5	766	Q9NZQ8
FWLCTIILTYLPTYI	SLC17A2	286	O00624
SFVGLIVIPATYYLW	SEC63	21	Q9UGP8
FWTPLTICYTLLVIY	TMEM82	236	A0PJX8
TVTSLCIYLDLPWYL	TLR6	601	Q9Y2C9
PWSYLVFLTIYGVEL	TPCN1	476	Q9ULQ1
WYYVVLGLVESVIIL	SLC35G1	256	Q2M3R5
IPVVFITLLLGWSYY	ZDHHC2	21	Q9UIJ5
VTLPSIACILIYYWS	TMEM129	101	A0AVI4