Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbenzodiazepine receptor binding

RIMBP3 RIMBP3C RIMBP3B

2.86e-0651333GO:0030156
GeneOntologyMolecularFunctionmonoacylglycerol lipase activity

ABHD15 ABHD16B ABHD12

1.52e-04161333GO:0047372
GeneOntologyMolecularFunctioncarbon-sulfur lyase activity

CENPVL2 CENPVL3 CENPVL1

1.52e-04161333GO:0016846
GeneOntologyMolecularFunctionthiolester hydrolase activity

PNKD PTPRT FASN ABHD12

2.69e-04471334GO:0016790
GeneOntologyMolecularFunctionlipase activity

GPLD1 ABHD15 PLCD4 ABHD16B SMPD2 ABHD12

3.27e-041381336GO:0016298
GeneOntologyBiologicalProcessglycerolipid metabolic process

GPLD1 SMG1 LRAT PIGB GPAA1 APOA5 INPP5E PLCD4 ABHD16B DGAT2 SERAC1 ABHD12 PCSK9

3.28e-0642913013GO:0046486
GeneOntologyBiologicalProcessphospholipid metabolic process

GPLD1 SMG1 LRAT PIGB GPAA1 INPP5E PLCD4 ABHD16B SERAC1 SMPD2 ABHD12 PCSK9

1.13e-0541013012GO:0006644
GeneOntologyBiologicalProcessglycerophospholipid metabolic process

GPLD1 SMG1 LRAT PIGB GPAA1 INPP5E PLCD4 ABHD16B SERAC1 ABHD12

3.62e-0532013010GO:0006650
GeneOntologyBiologicalProcessovarian follicle atresia

NEFH HYAL3

3.94e-0521302GO:0001552
GeneOntologyBiologicalProcessmodified amino acid catabolic process

DMGDH ALDH1L1 ABHD16B ABHD12

8.47e-05371304GO:0042219
GeneOntologyBiologicalProcessorganophosphate metabolic process

GPLD1 SMG1 LRAT PIGB GPAA1 INPP5E GART PLCD4 ALDH1L1 NT5C1B ABCC6 FASN ABHD16B DGAT2 SERAC1 SMPD2 ABHD12 NOS2 PCSK9

9.87e-05114213019GO:0019637
GeneOntologyBiologicalProcessneutral lipid catabolic process

GPLD1 APOA5 ABHD16B ABHD12

1.27e-04411304GO:0046461
GeneOntologyBiologicalProcessacylglycerol catabolic process

GPLD1 APOA5 ABHD16B ABHD12

1.27e-04411304GO:0046464
GeneOntologyBiologicalProcessmonoacylglycerol metabolic process

ABHD16B DGAT2 ABHD12

1.29e-04161303GO:0046462
GeneOntologyCellularComponentDsl1/NZR complex

NBAS RINT1

1.18e-0431322GO:0070939
Domain-

AASDH ALDH1L1 FASN

3.34e-06513131.10.1200.10
DomainPP-binding

AASDH ALDH1L1 FASN

3.34e-0651313PF00550
DomainACP_DOMAIN

AASDH ALDH1L1 FASN

3.34e-0651313PS50075
DomainPP-bd_ACP

AASDH ALDH1L1 FASN

6.64e-0661313IPR009081
DomainFN3

IGFN1 PTPRT CNTN6 RIMBP3 PTPRK ASTN1 RIMBP3C MYOM2 RIMBP3B

1.14e-051991319PS50853
DomainFN3_dom

IGFN1 PTPRT CNTN6 RIMBP3 PTPRK ASTN1 RIMBP3C MYOM2 RIMBP3B

1.69e-052091319IPR003961
DomainFN3

IGFN1 PTPRT CNTN6 PTPRK ASTN1 RIMBP3C MYOM2 RIMBP3B

4.88e-051851318SM00060
DomainGART_AS

GART ALDH1L1

1.46e-0431312IPR001555
DomainGART

GART ALDH1L1

1.46e-0431312PS00373
DomainMAM_1

ZAN PTPRT PTPRK

1.77e-04161313PS00740
Domain-

ABHD15 FAM135B FASN ABHD16B SERAC1 ABHD12

1.93e-0411913163.40.50.1820
DomainAB_hydrolase

ABHD15 FAM135B FASN ABHD16B SERAC1 ABHD12

1.93e-041191316IPR029058
DomainMAM

ZAN PTPRT PTPRK

2.13e-04171313SM00137
DomainMAM

ZAN PTPRT PTPRK

2.55e-04181313PF00629
DomainMAM_dom

ZAN PTPRT PTPRK

2.55e-04181313IPR000998
DomainMAM_2

ZAN PTPRT PTPRK

2.55e-04181313PS50060
Domain-

GART ALDH1L1

2.90e-04413123.40.50.170
DomainFormyl_transf_N

GART ALDH1L1

2.90e-0441312IPR002376
DomainFormyl_trans_N

GART ALDH1L1

2.90e-0441312PF00551
DomainPHOSPHOPANTETHEINE

ALDH1L1 FASN

4.82e-0451312PS00012
Pubmed

RIM-BP3 is a manchette-associated protein essential for spermiogenesis.

RIMBP3 RIMBP3C RIMBP3B

2.28e-074135319091768
Pubmed

Structure and evolution of RIM-BP genes: identification of a novel family member.

RIMBP3 RIMBP3C RIMBP3B

5.69e-075135317855024
Pubmed

Improving GENCODE reference gene annotation using a high-stringency proteogenomics workflow.

CENPVL2 CENPVL3 CENPVL1

1.13e-066135327250503
Pubmed

A mouse knockout library for secreted and transmembrane proteins.

APOA5 KLK12 PAPLN FAM131A PNKD SLITRK1 FGF22 DGAT2 CHPF2 FGF19

1.34e-054601351020562862
Pubmed

Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis.

IRF4 NOD2

1.50e-052135218188453
Pubmed

FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4.

FGFR4 FGF19

1.50e-052135210525310
Pubmed

Inducible nitric oxide synthase from bone marrow-derived cells plays a critical role in regulating colonic inflammation.

THY1 NOS2

1.50e-052135217449036
Pubmed

Association of Toll-like receptor 10 and susceptibility to Crohn's disease independent of NOD2.

NOD2 TLR10

1.50e-052135221716313
Pubmed

An olfactory receptor gene is located in the extended human beta-globin gene cluster and is expressed in erythroid cells.

OR52A5 OR52A1

1.50e-052135210512676
Pubmed

Nod2 Deficiency in mice is Associated with Microbiota Variation Favouring the Expansion of mucosal CD4+ LAP+ Regulatory Cells.

NOD2 NOS2

1.50e-052135230250234
Pubmed

Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity.

PAPPA FGF19

1.50e-052135211956156
Pubmed

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.

FGFR4 FGF19

1.50e-052135216213224
Pubmed

Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models.

FGFR4 FGF19

1.50e-052135217599042
Pubmed

Up-regulation of fibroblast growth factor 19 and its receptor associates with progression from fatty liver to hepatocellular carcinoma.

FGFR4 FGF19

1.50e-052135227447573
Pubmed

FGFR4 provides the conduit to facilitate FGF19 signaling in breast cancer progression.

FGFR4 FGF19

1.50e-052135230074276
Pubmed

FGF19 sustains the high proliferative ability of keratinocytes in psoriasis through the regulation of Wnt/GSK-3β/β-catenin signalling via FGFR4.

FGFR4 FGF19

1.50e-052135231074061
Pubmed

FGF19 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells by modulating the GSK3β/β- catenin signaling cascade via FGFR4 activation.

FGFR4 FGF19

1.50e-052135226498355
Pubmed

Chenodeoxycholate in females with irritable bowel syndrome-constipation: a pharmacodynamic and pharmacogenetic analysis.

FGFR4 FGF19

1.50e-052135220691689
Pubmed

Fibroblast growth factor 19 is correlated with an unfavorable prognosis and promotes progression by activating fibroblast growth factor receptor 4 in advanced-stage serous ovarian cancer.

FGFR4 FGF19

1.50e-052135226323668
Pubmed

ABCC6/MRP6 mutations: further insight into the molecular pathology of pseudoxanthoma elasticum.

ABCA4 ABCC6

1.50e-052135212673275
Pubmed

FGF19 amplification reveals an oncogenic dependency upon autocrine FGF19/FGFR4 signaling in head and neck squamous cell carcinoma.

FGFR4 FGF19

1.50e-052135230518874
Pubmed

The ileal FGF15/19 to hepatic FGFR4 axis regulates liver regeneration after partial hepatectomy in mice.

FGFR4 FGF19

1.50e-052135229468415
Pubmed

FGF19/FGFR4 signaling contributes to the resistance of hepatocellular carcinoma to sorafenib.

FGFR4 FGF19

1.50e-052135228069043
Pubmed

Expression of the Abca-subfamily of genes in Abcc6-/- mice--upregulation of Abca4.

ABCA4 ABCC6

1.50e-052135221435020
Pubmed

The transcription factor IRF4 determines the anti-tumor immunity of CD8+ T cells.

IRF4 THY1

1.50e-052135237860697
Pubmed

Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival.

FGFR4 FGF19

1.50e-052135227192118
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

VMP1 MAN2A2 GPAA1 LAMA5 POMT1 GAL RINT1 THY1 PTPRK HYAL3 CHPF2 FGFR4 PLOD1 ABHD12 MAN1B1 PCSK9

1.81e-0512011351635696571
Pubmed

Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.

RIMBP3 RIMBP3C RIMBP3B

2.02e-0514135317662146
Pubmed

A local source of FGF initiates development of the unmyelinated lineage of sensory neurons.

FGF22 NEFH FGFR4 FGF19

2.17e-0542135424198358
Pubmed

An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).

MAT2A GART ALDH1L1 NOS2

4.02e-0549135419161160
Pubmed

Development of a diagnostic genetic test for simplex and autosomal recessive retinitis pigmentosa.

CERKL LRAT ABCA4

4.47e-0518135320591486
Pubmed

INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse.

INPP5E AQP2

4.48e-053135219668215
Pubmed

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression.

FGFR4 FGF19

4.48e-053135219085950
Pubmed

Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice.

FGFR4 FGF19

4.48e-053135219706524
Pubmed

Alteration in the serum concentrations of FGF19, FGFR4 and βKlotho in patients with thyroid cancer.

FGFR4 FGF19

4.48e-053135229438906
Pubmed

FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action.

FGFR4 FGF19

4.48e-053135219237543
Pubmed

Liver-specific activities of FGF19 require Klotho beta.

FGFR4 FGF19

4.48e-053135217627937
Pubmed

Sulfated glycosaminoglycans are required for specific and sensitive fibroblast growth factor (FGF) 19 signaling via FGF receptor 4 and betaKlotho.

FGFR4 FGF19

4.48e-053135221653700
Pubmed

Role for NOD2 in Mycobacterium tuberculosis-induced iNOS expression and NO production in human macrophages.

NOD2 NOS2

4.48e-053135225801769
Pubmed

Hepatocyte FRS2α is essential for the endocrine fibroblast growth factor to limit the amplitude of bile acid production induced by prandial activity.

FGFR4 FGF19

4.48e-053135225056539
Pubmed

FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways.

FGFR4 FGF19

4.48e-053135221437243
Pubmed

FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation.

FGFR4 FGF19

4.48e-053135220018895
Pubmed

Enhanced autocrine FGF19/FGFR4 signaling drives the progression of lung squamous cell carcinoma, which responds to mTOR inhibitor AZD2104.

FGFR4 FGF19

4.48e-053135232111983
Pubmed

Fibroblast Growth Factor 19-Mediated Up-regulation of SYR-Related High-Mobility Group Box 18 Promotes Hepatocellular Carcinoma Metastasis by Transactivating Fibroblast Growth Factor Receptor 4 and Fms-Related Tyrosine Kinase 4.

FGFR4 FGF19

4.48e-053135231529503
Pubmed

Frequent methylation of the KLOTHO gene and overexpression of the FGFR4 receptor in invasive ductal carcinoma of the breast.

FGFR4 FGF19

4.48e-053135226152288
Pubmed

Feto-maternal cholesterol transport regulated by β-Klotho-FGF15 axis is essential for fetal growth.

FASN FGFR4 FGF19

5.30e-0519135337541847
Pubmed

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

FGF22 FGFR4 FGF19

5.30e-0519135316597617
Pubmed

Phospholipase C-gamma as a signal-transducing element.

FGF22 FGFR4 FGF19

7.23e-0521135310579907
Pubmed

Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes.

LRAT ABCA4

8.93e-054135221076393
Pubmed

FGF19 Protects Hepatocellular Carcinoma Cells against Endoplasmic Reticulum Stress via Activation of FGFR4-GSK3β-Nrf2 Signaling.

FGFR4 FGF19

8.93e-054135228951455
Pubmed

FGF19 and FGFR4 promotes the progression of gallbladder carcinoma in an autocrine pathway dependent on GPBAR1-cAMP-EGR1 axis.

FGFR4 FGF19

8.93e-054135234163030
Pubmed

FGF19-mediated ELF4 overexpression promotes colorectal cancer metastasis through transactivating FGFR4 and SRC.

FGFR4 FGF19

8.93e-054135236923538
Pubmed

Identification of sex hormone binding globulin-interacting proteins in the brain using phage display screening.

ZAN THY1

8.93e-054135219724880
Pubmed

FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway.

FGFR4 FGF19

8.93e-054135221641554
Pubmed

Association between C13ORF31, NOD2, RIPK2 and TLR10 polymorphisms and urothelial bladder cancer.

NOD2 TLR10

8.93e-054135222504414
Pubmed

NOD2 ligation subverts IFN-alpha production by liver plasmacytoid dendritic cells and inhibits their T cell allostimulatory activity via B7-H1 up-regulation.

IRF4 NOD2

8.93e-054135219890047
Pubmed

Involvement of all-trans-retinal in acute light-induced retinopathy of mice.

LRAT ABCA4

8.93e-054135219304658
Pubmed

Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina.

LRAT ABCA4

8.93e-054135218195010
Pubmed

Down-regulated in adenoma Cl/HCO3 exchanger couples with Na/H exchanger 3 for NaCl absorption in murine small intestine.

SLC9A4 SLC26A6

8.93e-054135218930060
Pubmed

Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.

FASN DGAT2 PCSK9

9.57e-0523135326508642
Pubmed

FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration.

FGF22 THY1 FGF19

9.57e-0523135323322300
Pubmed

The function of FGF signaling in the lens placode.

FGF22 FGFR4 FGF19

9.57e-0523135321223962
Pubmed

Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation.

FGF22 FGFR4 FGF19

1.24e-0425135311294897
Pubmed

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

ABHD15 APOA5 KLK12 PAPLN FAM131A PNKD SLITRK1 FGF22 TLR10 DGAT2 CHPF2 FGF19 MAN1B1

1.27e-049851351312975309
Pubmed

Expression of Fgf signalling pathway related genes during palatal rugae development in the mouse.

FGF22 FGFR4 FGF19

1.39e-0426135320348033
Pubmed

Breakpoint features of genomic rearrangements in neuroblastoma with unbalanced translocations and chromothripsis.

NBAS TENM4

1.48e-045135223991058
Pubmed

Candidate gene association resource (CARe): design, methods, and proof of concept.

APOA5 PCSK9

1.48e-045135220400780
Pubmed

NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6.

IRF4 NOD2

1.48e-045135224670424
Pubmed

Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery.

NBAS RINT1

1.48e-045135220462495
Pubmed

Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice.

LRAT ABCA4

1.48e-045135224706832
Pubmed

Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB.

FGFR4 FGF19

1.48e-045135222442730
Pubmed

Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4.

IRF4 NOD2

1.48e-045135228434881
Pubmed

Gene expression analysis of the late embryonic mouse cerebral cortex using DNA microarray: identification of several region- and layer-specific genes.

SOWAHA THY1 PTPRK NAV2

1.54e-0469135415142957
Pubmed

Fibroblast growth factor (FGF) gene expression in the developing cerebellum suggests multiple roles for FGF signaling during cerebellar morphogenesis and development.

FGF22 FGFR4 FGF19

1.56e-0427135319544582
Pubmed

FGF-2 deficiency does not influence FGF ligand and receptor expression during development of the nigrostriatal system.

FGF22 FGFR4 FGF19

1.94e-0429135321876757
Pubmed

Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study.

DMGDH MAT2A ALDH1L1

1.94e-0429135319048631
Pubmed

Palmitoylation stabilizes unliganded rod opsin.

LRAT ABCA4

2.22e-046135220404157
Pubmed

Postsynaptic CaV1.1-driven calcium signaling coordinates presynaptic differentiation at the developing neuromuscular junction.

NEFH SLC18A3

2.22e-046135231804576
Pubmed

POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells.

NEFH THY1

2.22e-04613528632990
Pubmed

Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport.

NBAS RINT1

2.22e-046135219369418
Pubmed

Comprehensive expression atlas of fibroblast growth factors and their receptors generated by a novel robotic in situ hybridization platform.

FGF22 FGFR4 FGF19

2.37e-0431135316123981
Pubmed

Transcriptome-based systematic identification of extracellular matrix proteins.

LAMA5 PAPLN NAV2 SERAC1

2.60e-0479135418757743
Pubmed

Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control.

CNTN6 GAL SLC18A3

2.61e-0432135327571008
Pubmed

Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate.

RFNG GFI1

3.10e-047135238383534
Pubmed

Loss of β-carotene 15,15'-oxygenase in developing mouse tissues alters esterification of retinol, cholesterol and diacylglycerols.

LRAT DGAT2

3.10e-047135223988655
Pubmed

Functional expression of pattern recognition receptors in tissues of the human female reproductive tract.

NOD2 TLR10

3.10e-047135219406482
Pubmed

Adipocyte STAT5 deficiency promotes adiposity and impairs lipid mobilisation in mice.

FASN DGAT2

3.10e-047135227858140
Pubmed

Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.

DMGDH APOA5 MAT2A GART ALDH1L1 POMT1 FGFR4

3.25e-04331135720634891
Pubmed

The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.

VMP1 INPP5E IARS1 GART FAM131A POMT1 FASN

3.31e-04332135737433992
Pubmed

Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.

CERKL LRAT ABCA4 ABCC6

3.77e-0487135420801516
Pubmed

betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c.

FGFR4 FGF19

4.12e-048135218187602
Pubmed

Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer.

TGFBRAP1 ZNF512

4.12e-048135227301951
Pubmed

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.

FGFR4 FGF19

4.12e-048135217623664
Pubmed

Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes.

RFNG FASN

4.12e-048135210341080
Pubmed

Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization.

LAMA5 PTPRT

4.12e-048135210760573
Pubmed

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.

SMG1 TTI2

4.12e-048135220810650
Pubmed

Sensory-motor deficits and neurofilament disorganization in gigaxonin-null mice.

NEFH SLC18A3

4.12e-048135221486449
Pubmed

A Large-scale genetic association study of esophageal adenocarcinoma risk.

ERCC6 ALDH1L1 NOD2 TLR10 LIG3 FGFR4 NOS2

4.61e-04351135720453000
Pubmed

The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex.

ASIC2 NEFH EML5 PTPRK

5.91e-0498135419554387
Pubmed

Tissue- and sex-specific effects of β-carotene 15,15' oxygenase (BCO1) on retinoid and lipid metabolism in adult and developing mice.

LRAT DGAT2

6.59e-0410135225602705
InteractionC1QB interactions

MAN2A2 GAS6 LAMA5 CHPF2 FGFR4 ZRANB1 PCSK9

2.29e-06941287int:C1QB
InteractionDNASE1L1 interactions

MAN2A2 LAMA5 PTPRK CHPF2 FGFR4 ABHD12 PCSK9

1.16e-051201287int:DNASE1L1
Cytoband17q11.2-q12

LIG3 NOS2

1.79e-047135217q11.2-q12
GeneFamilyFibronectin type III domain containing

IGFN1 PTPRT CNTN6 PTPRK ASTN1 MYOM2

1.39e-04160896555
GeneFamilyAbhydrolase domain containing

ABHD15 ABHD16B ABHD12

1.66e-04228934
GeneFamilyADAMTS like

PAPLN ADAMTSL2

4.95e-047892947
GeneFamilyDolichyl D-mannosyl phosphate dependent mannosyltransferases|Phosphatidylinositol glycan anchor biosynthesis

PIGB POMT1

8.43e-049892430
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

IGFN1 PAPLN CNTN6 MYOM2 FGFR4

1.20e-03161895593
GeneFamilySolute carriers

SLC25A46 SLC16A13 SLC5A10 SLC38A9 SLC9A4 SLC18A3 SLC26A6

3.34e-03395897752
CoexpressionBENPORATH_SUZ12_TARGETS

ASIC2 ALDH1L1 PIR SLITRK1 GFI1 ABCC6 PTPRT RIMBP3 NEFH EML5 SLC18A3 NAV2 ASTN1 PAPPA RIMBP3C VWA3B RIMBP3B PCSK9

5.15e-06103513318M9898
ToppCell3'-Child09-12-SmallIntestine-Epithelial-Tuft-related-Tuft|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AOC1 PTPRT CNTN6 SLC18A3 NAV2 FGFR4 ST18

8.61e-07169135705e12524d68d409fed386ffad233305683b4575b
ToppCellLA-11._Adipocyte|World / Chamber and Cluster_Paper

GPLD1 ALDH1L1 ABCC6 FASN TENM4 DGAT2 SNTB1

1.47e-061831357b177be283e1553fb1f69a346f1ba79ad00297fa2
ToppCellLA-11._Adipocyte|LA / Chamber and Cluster_Paper

GPLD1 ALDH1L1 ABCC6 FASN TENM4 DGAT2 SNTB1

1.47e-0618313573f9011976782fa8aa95cdd6f00f07a91094d411b
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)|Cerebellum / BrainAtlas - Mouse McCarroll V32

ZAN ABCC6 NOD2 NOS2 ADAMTSL2

6.11e-06851355bb9555652e93620d5aeeb71e915b3978a437407d
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)--|Cerebellum / BrainAtlas - Mouse McCarroll V32

ZAN ABCC6 NOD2 NOS2 ADAMTSL2

6.11e-06851355f7935c3206310adafdecb75149c3b06c38e7780c
ToppCellCerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

ZAN ABCC6 NOD2 NOS2 ADAMTSL2

6.11e-0685135543f6911b032718d8ba75fb7bba5f9b536a4b3260
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Ttn_(red_nucleus,_magnocellular/parvicellular_(RMC/RPC))-|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

IGFN1 SLC5A10 GAL SLC9A4

1.05e-05451354a5d7f4dacfdbecf7d82b2bc75fc3668b9a208abb
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Ttn_(red_nucleus,_magnocellular/parvicellular_(RMC/RPC))|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

IGFN1 SLC5A10 GAL SLC9A4

1.05e-054513544e9fd1e4fecb51298f66ca5e1ec87a2a7d314724
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Ttn_(red_nucleus,_magnocellular/parvicellular_(RMC/RPC))--|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

IGFN1 SLC5A10 GAL SLC9A4

1.05e-0545135434020aa7499e57d7560d7f5cf91c3bd1e69ce481
ToppCelldroplet-Kidney-nan-3m-Lymphocytic-CD45____NK_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP37 KCNK7 WDR47 NEFH THY1 ZNF512

1.05e-051631356a763c1632d6465a1e753bdc8eadaf819d2b09e5e
ToppCelldroplet-Kidney-nan-3m-Lymphocytic-NK_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP37 KCNK7 WDR47 NEFH THY1 ZNF512

1.05e-051631356eaed783eecd07aafa5af844b63c9d816b4da99e4
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-Tuft|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AOC1 RTKN PTPRT CNTN6 FGFR4 ST18

1.74e-051781356f17c3b7bb562ac24c6a03fe3c9ba94c2b434c141
ToppCellfacs-Liver-Hepatocytes-24m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPLD1 DMGDH ABCC6 RNF103 FGFR4 PCSK9

2.03e-051831356d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFN1 ABCA4 ZAN TENM4 MYOM2 ST18

2.09e-0518413562cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFN1 ABCA4 ZAN TENM4 MYOM2 ST18

2.09e-051841356ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IGFN1 ABCA4 ZAN TENM4 MYOM2 ST18

2.09e-0518413562b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellwk_15-18-Epithelial-PNS-FGFBP2+_Neural_progenitor|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PLCD4 RTKN SLITRK1 GAL EML5 ST18

2.66e-051921356ab54d4bfc61ef7e3d765afe6e4a6d7011a301ecd
ToppCellwk_20-22-Hematologic-Myeloid-DC1|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

LRRK1 TLR10 CENPVL2 DGAT2 CENPVL1 ST18

2.74e-051931356a260d943e9db966e4ce7d642313fd11354c2d2ba
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)|390C / Donor, Lineage, Cell class and subclass (all cells)

GAS6 TMEM175 LAMA5 RTKN PDCD11 SMPD2

2.82e-05194135688db9f9e80c20ff3474f1f6459dcbdc25aec0b6d
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)-|390C / Donor, Lineage, Cell class and subclass (all cells)

GAS6 TMEM175 LAMA5 RTKN PDCD11 SMPD2

2.82e-051941356a71728202493d4858342ea2756ea281cd0d99a3a
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-immature_T_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DMGDH FAM131A RTKN NAV2 SERAC1

5.15e-0513213559936078c328b1e1d59f9dfdd69d36926a0cdaf0d
DrugAC1Q5SG4

DMGDH AOC1 MAT2A GART PSMB4 ALDH1L1 NOS2 PCSK9

4.77e-071211308CID000001129
DrugTriglycerides

GPLD1 APOA5 FASN DGAT2 NOS2 FGF19

2.12e-06661306ctd:D014280
Diseaseinfantile liver failure syndrome (is_implicated_in)

NBAS RINT1

5.33e-0531252DOID:0080716 (is_implicated_in)
Diseasecarboxypeptidase M measurement

GPLD1 ABHD12

1.06e-0441252EFO_0801454
Diseaseapolipoprotein A-IV measurement

APOA5 SOWAHA

1.77e-0451252EFO_0007848
DiseaseRetinal Dystrophy, Early Onset Severe

LRAT ABCA4

1.77e-0451252C1858080
Diseaselarynx cancer (is_implicated_in)

ERCC6 NOD2

2.64e-0461252DOID:2596 (is_implicated_in)
DiseaseEye Diseases, Hereditary

LRAT INPP5E

2.64e-0461252C0015398
Diseaseleukemia (is_marker_for)

IRF4 GFI1

3.69e-0471252DOID:1240 (is_marker_for)
Diseasehypothyroidism (biomarker_via_orthology)

APOA5 NEFH PLOD1 NOS2

3.78e-04801254DOID:1459 (biomarker_via_orthology)
Diseasetriglyceride measurement, metabolic syndrome

APOA5 ZNF512

4.90e-0481252EFO_0000195, EFO_0004530
Diseaselipid measurement, lipoprotein measurement

APOA5 GAS6 DGAT2 PCSK9

5.92e-04901254EFO_0004529, EFO_0004732
Diseaseinterleukin 18 receptor accessory protein measurement

SLC9A4 PRRT1

6.29e-0491252EFO_0008179
Diseasemultiple sclerosis, chronic lymphocytic leukemia

VMP1 PTPRK

6.29e-0491252EFO_0000095, MONDO_0005301
Diseasemiddle cerebral artery infarction (biomarker_via_orthology)

ERCC6 IRF4 NOD2 NOS2

6.70e-04931254DOID:3525 (biomarker_via_orthology)
Diseaseserum metabolite measurement

DMGDH AOC1 GPAA1 POC1A APOA5 ALDH1L1 PTPRT GAL KCNT2 MYOM2 SNTB1 PCSK9

6.96e-0494512512EFO_0005653
Diseaseretinitis pigmentosa (is_implicated_in)

CERKL LRAT ABCA4

7.03e-04411253DOID:10584 (is_implicated_in)
DiseaseOptic Atrophy

SLC25A46 ABHD12

7.84e-04101252C0029124
DiseaseNephroblastoma

NBAS PCSK9

7.84e-04101252Orphanet_654
DiseaseRetinitis Pigmentosa

CERKL LRAT ABCA4 ABHD12

1.02e-031041254C0035334
DiseaseTPE interval measurement

AOC1 FAAP20 LIG3

1.41e-03521253EFO_0004644
Diseasenodular sclerosis Hodgkin lymphoma

PTPRK PRRT1

1.57e-03141252EFO_0004708
Diseasefertility measurement

NBAS NAV2

1.57e-03141252EFO_0006923
Diseasefemoral neck bone geometry

GAL FGFR4

1.57e-03141252EFO_0004511
DiseaseArthritis, Psoriatic

NOD2 NOS2

1.57e-03141252C0003872
Diseasecomplement factor H-related protein 1 measurement

CENPVL2 CENPVL3 KCNT2

1.75e-03561253EFO_0600054
DiseaseOpioid use measurement

MYOM2 SNTB1

1.80e-03151252EFO_0009937
Diseaserespiratory symptom change measurement, response to placebo

CNTN6 NAV2

2.32e-03171252EFO_0008344, EFO_0010068
DiseaseHETE measurement

APOA5 CNTN6 NBAS

2.34e-03621253EFO_0801166
Diseasepolyunsaturated fatty acid measurement

APOA5 GAS6 DGAT2 PCSK9

2.38e-031311254EFO_0010733
DiseaseAge-related macular degeneration

ABCA4 ERCC6

2.61e-03181252cv:C0242383
DiseaseCoronary Arteriosclerosis

APOA5 PAPPA PCSK9

2.68e-03651253C0010054
DiseaseCoronary Artery Disease

APOA5 PAPPA PCSK9

2.68e-03651253C1956346
Diseasemetabolite measurement

DMGDH AOC1 GPAA1 ALDH1L1 NBAS GAL ZNF512 PCSK9

2.71e-035601258EFO_0004725
DiseaseProfound Mental Retardation

INPP5E TTI2 FASN MAN1B1

2.94e-031391254C0020796
DiseaseMental Retardation, Psychosocial

INPP5E TTI2 FASN MAN1B1

2.94e-031391254C0025363
DiseaseMental deficiency

INPP5E TTI2 FASN MAN1B1

2.94e-031391254C0917816
DiseaseIntellectual Disability

PIGB INPP5E TTI2 FASN ASTN1 SERAC1 MAN1B1

3.01e-034471257C3714756
Diseaseleprosy, Crohn's disease

NOD2 SLC9A4

3.22e-03201252EFO_0000384, EFO_0001054
DiseaseInfiltrating duct carcinoma of female breast

ANKK1 SMG1

3.55e-03211252C3165106
DiseaseArthrogryposis

ERCC6 SLC18A3

3.55e-03211252C0003886
DiseaseRetinitis pigmentosa

CERKL LRAT ABCA4

3.86e-03741253cv:C0035334
Diseaselung cancer (is_implicated_in)

ERCC6 MAT2A NOD2

3.86e-03741253DOID:1324 (is_implicated_in)
Diseasealkaline phosphatase measurement

GPLD1 AOC1 INPP5E GAS6 PAPLN PNKD RNF103 ZNF45 CHPF2 ABHD12 ADAMTSL2

3.97e-03101512511EFO_0004533

Protein segments in the cluster

PeptideGeneStartEntry
GTALGPCHTIRIYIH

NT5C1B

71

Q96P26
THFPRVYGVSLATHL

BARGIN

276

Q6ZT62
FSVALGHLLGIHYTG

AQP2

166

P41181
HGRILHYSDPFILFL

ABCA4

721

P78363
TPLHVAAYFGHVSLV

ANKK1

496

Q8NFD2
LAGLYRGQALHGRHP

FGFR4

386

P22455
FHPYAESLVSGIGRH

APOA5

191

Q6Q788
LIPHHLYFATLGGLL

AASDH

906

Q4L235
LLDTFEYPGLVHHTG

CENPVL1

121

A0A0U1RR11
LVAGFRLGVTSHGHY

FAM187A

351

A6NFU0
HATFYTPEGLRHGTR

AOC1

486

P19801
PFRVAILHETGSYTH

ERCC6

591

Q03468
IHYIPSVLIGGHGRE

ASTN1

201

O14525
HSNPYFFLLLSRHGG

ABHD15

376

Q6UXT9
LHRLHFPPAHLVVYG

ABHD16B

231

Q9H3Z7
LHGIRHIFVYGPLTI

ASIC2

26

Q16515
KYILAHFRGHPALSG

RIMBP3B

201

A6NNM3
KYILAHFRGHPALSG

RIMBP3C

201

A6NJZ7
GLLGARLLHSPLFHS

RFNG

246

Q9Y644
LLGDGHSYSPRAIHS

PSMB4

121

P28070
SSHPIILYLHGNAGT

ABHD12

166

Q8N2K0
GVLHAVHTAYSRLPG

NOS2

1036

P35228
SHGRLSYHILAGNSP

DCHS1

716

Q96JQ0
GRLLYTLHGHQGPAT

POC1A

261

Q8NBT0
YRLLHGAGGHLESPA

FAAP20

101

Q6NZ36
AAAGLLYPERGHGLH

GFI1

216

Q99684
EHHTYGALLFPLLSL

GPAA1

591

O43292
LGPHYVLLSSAAHGV

INPP5E

356

Q9NRR6
SGHFLRGYDLPEHIS

IRF4

421

Q15306
IRHSGFSVTHPGYLG

KLK12

86

Q9UKR0
ILHNRIPYGSHIIPF

LRR1

331

Q96L50
LLHFPDTSHGLRNLY

LRRK1

906

Q38SD2
AIGVSHPLSISIFHY

MAT2A

321

P31153
GRGRSLHPVIYHLGQ

KCNK7

221

Q9Y2U2
GYLTKILHVFHGLLP

PCSK9

106

Q8NBP7
GHLSAVYGLDLHPTI

PLRG1

286

O43660
GHVLGLPHTYRTGSI

MMP21

286

Q8N119
YLPLISLSLVHRYGH

OR51F2

266

Q8NH61
RFGSHISPYIHILFS

OR52A1

266

Q9UKL2
RFGSHIPPYIHILLS

OR52A5

266

Q9H2C5
HPHRGFETVSYLLEG

PIR

56

O00625
PIRLRHLYTSGPHGL

FGF19

41

O95750
HLGYSLVTHIPAGAR

ADAMTSL2

226

Q86TH1
LEVPRTHLTHYGIYL

LRAT

51

O95237
PGGRTRRYHLSAHFL

FGF22

151

Q9HCT0
GATRGFYPHLLLALV

MROH6

256

A6NGR9
RSFYHGPSRLPVHSI

KCNT2

576

Q6UVM3
THVPTLGRYAFLLHG

LAMA5

1291

O15230
SYHRLVLTALDGGHP

PCDHGB5

206

Q9Y5G0
HSLGLYHVFRGISEI

PAPPA

566

Q13219
SRATYLVFLPGLHVG

LIG3

66

P49916
TAIYHPGHRLLLVGG

NBAS

241

A2RRP1
GTLALGVYHGLPASH

MAN1B1

531

Q9UKM7
HYHEGLPTTRGTRYI

PLOD1

706

Q02809
RNETHHLFVGLYPGT

PTPRT

546

O14522
TYPAAHHFRSGIIGS

SMPD2

66

O60906
FYVHLILVFRSGPHD

POMT1

281

Q9Y6A1
APLHGGGSLHYALAR

NEFH

16

P12036
LLDTFEYPGLVHHTG

CENPVL2

121

P0DPI3
LYHLNLTVGGIPFHE

GAS6

416

Q14393
YLLGPHAVGNHRSFS

GAL

41

P22466
LLDTFEYPGLVHHTG

CENPVL3

121

A0A0U1RRI6
YRTLFGALHLHLGGA

DNAH7

1311

Q8WXX0
ALAAYQIHHSLRPGF

HYAL3

106

O43820
LGPHLQDLFTGHRFS

FAM131A

216

Q6UXB0
VHIRLHPRLISLYGG

CERKL

536

Q49MI3
HYRLDGGSLAINSPH

CNTN6

76

Q9UQ52
HAAGLTTYFHPGINL

DMGDH

91

Q9UI17
GHRTLPSSVRIYLHG

MAN2A2

726

P49641
SAFHASLLPGRHPYL

KIAA1210

11

Q9ULL0
HLSHGNLTVLYGGLL

CENATAC

76

Q86UT8
LLGILPGHEYHFRVV

IGFN1

1101

Q86VF2
RAPGNSIRLHFVHGY

EML5

671

Q05BV3
HTFLSLSGPHLGTLY

FAM135B

1241

Q49AJ0
LAGHGHLYSRIPGLL

FASN

1246

P49327
HHYHQSGTATLPRLG

PRRT1

46

Q99946
HPALFLSTYLGHGLL

RNF103

416

O00237
LLGHIFGDIYPSIFH

SLC38A9

466

Q8NBW4
LTTRNYIFGYHPHGI

DGAT2

151

Q96PD7
HGVPYHATGLLSFIR

PTPRK

1051

Q15262
GIPVGFHLYSTHAAL

OIP5

141

O43482
YTHFGSHSPGRARVL

FREM3

126

P0C091
THLPEGRIGSHIYVY

PIGB

526

Q92521
VGGPRYHLLAHTTLT

RTKN

251

Q9BST9
HTYPLLATRLVHSGP

SNTB1

371

Q13884
GIIFYSVPHHGSRLA

SERAC1

526

Q96JX3
AYALGPIVAGHIVHS

SLC18A3

431

Q16572
TPGHTQGHLVYLLDG

PNKD

226

Q8N490
PVVYHGHTLTSRILF

PLCD4

346

Q9BRC7
HLNTVFLGFRTLPHY

TLR10

166

Q9BXR5
DIGFIYHSPGHTLLR

FER1L5

251

A0AVI2
VLGPIYLLFIHHHGR

ABCC6

46

O95255
KYILAHFRGHPALSG

RIMBP3

201

Q9UFD9
LKYVFGLHLSSHSGP

SLC26A6

231

Q9BXS9
GLHLSSHSGPLSLIY

SLC26A6

236

Q9BXS9
PRFHARHYSVTPLGT

SMG1

2186

Q96Q15
LPLFHHARYELVHGS

NAV2

1656

Q8IVL1
SLAKIGFHLYHRLPG

SLC9A4

81

Q6AI14
TGLPHYGHILAGTIK

IARS1

51

P41252
GVLGALLEHRGHAPY

KIF25

301

Q9UIL4
FYLLGFPGSEELHHI

OR9A4

11

Q8NGU2
TGHVTGLYPHHRSLS

ST18

376

O60284
SAPRHGSIIYHPSLL

ALDH1L1

96

O75891
GSIIYHPSLLPRHRG

ALDH1L1

101

O75891
HHFPRLLYFTGQRGA

CHPF2

126

Q9P2E5
HGSHLYTSLPSLGLE

VGLL4

116

Q14135
FRLGPSVVGLARYSH

PDCD11

1341

Q14690
AHGLGFLLAHPSATR

TMEM86A

56

Q8N2M4
RSVRFSPGAHYLLTG

WDR47

846

O94967
FHTLLAIYLHAGPTA

TGFBRAP1

716

Q8WUH2
LHYLGSHAFSFPLLI

TMC8

591

Q8IU68
LIVGYAFHFPHLLSP

TMEM175

156

Q9BSA9
QLTSLLHHGPFLRYT

SLC16A13

206

Q7RTY0
LHHGPFLRYTVALTL

SLC16A13

211

Q7RTY0
YEGFHLLGQPLSHLA

NOD2

71

Q9HC29
YHLFLHGNSLTRLFP

SLITRK1

61

Q96PX8
LLFERELHSVHGYPG

RINT1

406

Q6NUQ1
RSHGGYTPLHLAALH

SOWAHA

381

Q2M3V2
GGTRGRIYIKHPHLF

DNTTIP1

226

Q9H147
GHRVHQSPDGTLLIY

PAPLN

1176

O95428
FPTVLHGVLHYIISS

SLC25A46

266

Q96AG3
PDTRPAVLGSIHYLH

SLC5A10

501

A0PJK1
TGLHHLAGPVYIFAI

TTI2

141

Q6NXR4
FLYHRRTHGVGGVPL

ZNF574

406

Q6ZN55
SRPGHIHIGRVYLIY

GPLD1

406

P80108
HVLFGTVGVPEHTYR

THY1

61

P04216
GHLLHTFYLGTGRRV

TENM4

1996

Q6N022
YLTHRLSGPVHGLQF

WDR46

441

O15213
IYSHSLLPVLRSGHV

GART

661

P22102
HYNTGGIPRIFQLSH

USP37

41

Q86T82
TAHLHFPAAGRLGLS

VWA3B

1246

Q502W6
GLAYHLRSEHGPISF

ZNF512

301

Q96ME7
FLAHRGVHTGEKPYR

ZNF45

571

Q02386
PIALGYTRGHFSALV

ZRANB1

576

Q9UGI0
FISYPSLFGHLRVHN

ZNF560

441

Q96MR9
HYILRGQSPGAALHI

ZAN

291

Q9Y493
PLGQLHSHLGAYFVT

TMPPE

261

Q6ZT21
LHTFLLYLGPHIASV

VMP1

131

Q96GC9
HKPIGYNRFVVHGLT

MYOM2

661

P54296