Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionN-acetylmuramoyl-L-alanine amidase activity

PGLYRP4 PGLYRP3

7.87e-054732GO:0008745
GeneOntologyMolecularFunctionpeptidoglycan immune receptor activity

PGLYRP4 PGLYRP3

1.31e-045732GO:0016019
GeneOntologyBiologicalProcessnegative regulation of natural killer cell differentiation

PGLYRP4 PGLYRP3

7.18e-054722GO:0032824
GeneOntologyBiologicalProcessnegative regulation of natural killer cell differentiation involved in immune response

PGLYRP4 PGLYRP3

7.18e-054722GO:0032827
GeneOntologyBiologicalProcessprotein localization to cell periphery

TTC8 PACS1 MISP NPTX1 MAL ADIPOQ TTC7B LRP1

1.10e-04422728GO:1990778
GeneOntologyBiologicalProcessnatural killer cell differentiation involved in immune response

PGLYRP4 PGLYRP3

1.19e-045722GO:0002325
GeneOntologyBiologicalProcessprotein localization to paranode region of axon

MAL CNTNAP1

1.19e-045722GO:0002175
GeneOntologyBiologicalProcessregulation of natural killer cell differentiation involved in immune response

PGLYRP4 PGLYRP3

1.19e-045722GO:0032826
GeneOntologyBiologicalProcesspeptidoglycan catabolic process

PGLYRP4 PGLYRP3

1.79e-046722GO:0009253
GeneOntologyBiologicalProcesspeptidoglycan metabolic process

PGLYRP4 PGLYRP3

1.79e-046722GO:0000270
GeneOntologyBiologicalProcessaxon ensheathment in central nervous system

MAL KCNJ10 CNTNAP1

2.06e-0433723GO:0032291
GeneOntologyBiologicalProcesscentral nervous system myelination

MAL KCNJ10 CNTNAP1

2.06e-0433723GO:0022010
MousePhenointestinal ulcer

MISP PGLYRP4 FADS2 PGLYRP3

3.27e-0624614MP:0000512
MousePhenogastrointestinal ulcer

MISP PGLYRP4 FADS2 PGLYRP3

9.45e-0631614MP:0003300
DomainDVL-1

DVL1P1 DVL1

1.55e-052742IPR008340
DomainAmidase_domain

PGLYRP4 PGLYRP3

9.24e-054742IPR002502
DomainAmi_2

PGLYRP4 PGLYRP3

9.24e-054742SM00644
Domain-

PGLYRP4 PGLYRP3

9.24e-0547423.40.80.10
DomainPGRP

PGLYRP4 PGLYRP3

9.24e-054742SM00701
DomainDishevelled_fam

DVL1P1 DVL1

9.24e-054742IPR008339
DomainAmidase_2

PGLYRP4 PGLYRP3

9.24e-054742PF01510
DomainDishevelled

DVL1P1 DVL1

9.24e-054742PF02377
DomainDishevelled_protein_dom

DVL1P1 DVL1

9.24e-054742IPR003351
DomainPGRP_domain_met/bac

PGLYRP4 PGLYRP3

9.24e-054742IPR006619
DomainPGRP

PGLYRP4 PGLYRP3

9.24e-054742IPR015510
DomainDIX

DVL1P1 DVL1

3.21e-047742PF00778
DomainDIX

DVL1P1 DVL1

3.21e-047742IPR001158
DomainDIX

DVL1P1 DVL1

3.21e-047742PS50841
DomainDAX

DVL1P1 DVL1

3.21e-047742SM00021
Pubmed

A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

DOCK1 ZSWIM8 ABI1 MAP3K8 TM9SF3 LOXL4 MMS19 BTAF1

3.57e-0641576816385451
Pubmed

Peptidoglycan recognition proteins Pglyrp3 and Pglyrp4 are encoded from the epidermal differentiation complex and are candidate genes for the Psors4 locus on chromosome 1q21.

PGLYRP4 PGLYRP3

4.71e-06276216362825
Pubmed

Murine peptidoglycan recognition proteins PglyrpIalpha and PglyrpIbeta are encoded in the epidermal differentiation complex and are expressed in epidermal and hematopoietic tissues.

PGLYRP4 PGLYRP3

4.71e-06276215177568
Pubmed

Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.

DVL1P1 DVL1

4.71e-0627628644734
Pubmed

Spatiotemporal expression of retrogene-host pair Mcts2/H13 in mouse embryo, and Mcts2 has no influence on H13 transcription pattern in NIH/3T3 cells.

MCTS2 MCTS1

1.41e-05376224063864
Pubmed

Peptidoglycan recognition proteins are a new class of human bactericidal proteins.

PGLYRP4 PGLYRP3

1.41e-05376216354652
Pubmed

A Novel Innate Response of Human Corneal Epithelium to Heat-killed Candida albicans by Producing Peptidoglycan Recognition Proteins.

PGLYRP4 PGLYRP3

1.41e-05376226039076
Pubmed

Cot/tpl2 participates in the activation of macrophages by adiponectin.

ADIPOQ MAP3K8

1.41e-05376224532642
Pubmed

Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins.

PGLYRP4 PGLYRP3

1.41e-05376217502600
Pubmed

Functions of Peptidoglycan Recognition Proteins (Pglyrps) at the Ocular Surface: Bacterial Keratitis in Gene-Targeted Mice Deficient in Pglyrp-2, -3 and -4.

PGLYRP4 PGLYRP3

1.41e-05376226332373
Pubmed

TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells.

TARDBP CNTNAP1

1.41e-05376233689679
Pubmed

cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.

DVL1P1 DVL1

2.82e-0547628817329
Pubmed

Peptidoglycan recognition proteins protect mice from experimental colitis by promoting normal gut flora and preventing induction of interferon-gamma.

PGLYRP4 PGLYRP3

2.82e-05476220709292
Pubmed

A case-by-case evolutionary analysis of four imprinted retrogenes.

MCTS2 MCTS1

2.82e-05476221166792
Pubmed

Human dishevelled genes constitute a DHR-containing multigene family.

DVL1P1 DVL1

2.82e-0547629192851
Pubmed

Non-canonical Wnt signaling induces ubiquitination and degradation of Syndecan4.

DVL1P1 DVL1

2.82e-05476220639201
Pubmed

Pglyrp-Regulated Gut Microflora Prevotella falsenii, Parabacteroides distasonis and Bacteroides eggerthii Enhance and Alistipes finegoldii Attenuates Colitis in Mice.

PGLYRP4 PGLYRP3

2.82e-05476226727498
Pubmed

Adiponectin promotes endotoxin tolerance in macrophages by inducing IRAK-M expression.

ADIPOQ MAP3K8

2.82e-05476219414798
Pubmed

Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules.

PGLYRP4 PGLYRP3

2.82e-05476211461926
Pubmed

Differential effects of peptidoglycan recognition proteins on experimental atopic and contact dermatitis mediated by Treg and Th17 cells.

PGLYRP4 PGLYRP3

2.82e-05476221949809
Pubmed

Peptidoglycan recognition protein Pglyrp2 protects mice from psoriasis-like skin inflammation by promoting regulatory T cells and limiting Th17 responses.

PGLYRP4 PGLYRP3

4.69e-05576222048773
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

PDXDC1 ADIPOQ P3H3 TM9SF3 CNTNAP1 LRP1 FADS2 LOXL4 RARS2 PNPLA7 CSGALNACT1 ADPGK

6.96e-051451761230550785
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

DOCK1 CNTNAP1 MMS19 BTAF1 ADPGK

8.32e-0520276533005030
Pubmed

EWS splicing regulation contributes to balancing Foxp1 isoforms required for neuronal differentiation.

ABI1 DVL1

9.83e-05776235253879
Pubmed

A screen for retrotransposed imprinted genes reveals an association between X chromosome homology and maternal germ-line methylation.

MCTS2 MCTS1

1.31e-04876217291163
Pubmed

A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5).

DVL1P1 DVL1

1.31e-04876219643732
Pubmed

PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation.

PGLYRP4 PGLYRP3

1.31e-04876219218085
Pubmed

Genomic analysis of mouse retinal development.

PITPNM2 ZSWIM8 ABI1 TTC7B CLK2 DVL1 KDM3B MMS19 PNPLA7

3.44e-04100676915226823
Pubmed

Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses.

ABI1 GRM1

4.22e-041476221795692
Pubmed

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.

TARDBP ABI1 P3H3 DUS3L

4.38e-0416176432572027
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

PDXDC1 TARDBP MISP P3H3 PREP CNTNAP1 KDM3B MMS19 ARHGEF17 ADPGK

5.13e-041297761033545068
Pubmed

Biological insights from 108 schizophrenia-associated genetic loci.

PITPNM2 LRP1 KDM3B ESAM MYO15A

5.41e-0430376525056061
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

MCTS2 PITPNM2 ZSWIM8 NPTX1 TTC7B MCTS1

6.13e-0447576631040226
Pubmed

HIV tat and neurotoxicity.

LRP1 GRM1

7.87e-041976216697675
Pubmed

The Role of Sorting Nexin 17 in Cardiac Development.

DVL1 LRP1

7.87e-041976234988124
Pubmed

A Y2H-seq approach defines the human protein methyltransferase interactome.

MAGEB2 KDM3B LOXL4 BCAT1 OPA3

9.32e-0434276523455924
Pubmed

Discovery and refinement of loci associated with lipid levels.

PDXDC1 AOC1 LRP1 FADS2

1.20e-0321176424097068
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

NPTX1 P3H3 TM9SF3 CNTNAP1 LRP1 FADS2 RXYLT1 CSGALNACT1 ADPGK

1.21e-03120176935696571
Pubmed

SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation.

TTC7B MCTS1

1.26e-032476218425126
Pubmed

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

CD163L1 TM9SF3 PCDHB13 SH2D3A ESAM CRISPLD1 CSGALNACT1 SDHD

1.39e-0398576812975309
Pubmed

Developmental gene expression profiling along the tonotopic axis of the mouse cochlea.

KCNJ10 MYO15A

1.72e-032876222808246
Pubmed

Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.

PDXDC1 FADS2

1.84e-032976221829377
Pubmed

Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function.

MAL KCNJ10

1.97e-033076227568567
Pubmed

Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations.

TTC8 ADIPOQ

1.97e-033076219077438
Cytoband1q21

PGLYRP4 CLK2 PGLYRP3

4.96e-04917731q21
Cytoband19p13.3

MISP SH2D3A FSD1 DUS3L

6.97e-0423777419p13.3
CoexpressionMIKKELSEN_NPC_ICP_WITH_H3K4ME3

ZNF276 CFAP52 MCTS1 CNTNAP1 PCDHB13 LRP1 TBC1D22B GMPPA CTSO

6.05e-06449769M2013
CoexpressionMIKKELSEN_NPC_ICP_WITH_H3K4ME3

ZNF276 CFAP52 MCTS1 CNTNAP1 PCDHB13 LRP1 TBC1D22B GMPPA CTSO

1.36e-05497769MM863
Disease1-oleoyl-2-dihomo-linolenoyl-GPC (18:1/20:3) measurement

PDXDC1 FADS2

1.86e-053742EFO_0800461
Disease1-dihomo-linolenoyl-GPC (20:3n3 or 6) measurement

PDXDC1 FADS2

3.71e-054742EFO_0800235
DiseaseDiGeorge syndrome (is_implicated_in)

DVL1P1 DVL1

6.17e-055742DOID:11198 (is_implicated_in)
Disease1-palmitoyl-2-dihomo-linolenoyl-GPC (16:0/20:3n3 or 6) measurement

PDXDC1 FADS2

6.17e-055742EFO_0800407
Diseasedihomo-linolenate 20:3n3 or n6 measurement

PDXDC1 FADS2

9.25e-056742EFO_0021046
Disease1-palmitoyl-2-arachidonoyl-GPC (16:0/20:4n6) measurement

PDXDC1 FADS2

9.25e-056742EFO_0800390
Disease1-stearoyl-2-dihomo-linolenoyl-GPC (18:0/20:3n3 or 6) measurement

PDXDC1 FADS2

9.25e-056742EFO_0800434
Disease1-dihomo-linolenoyl-GPE (20:3n3 or 6) measurement

PDXDC1 FADS2

9.25e-056742EFO_0800358
DiseaseToxoplasma gondii seropositivity

TTC8 SLC17A9

1.29e-047742EFO_0007047
Diseasefatty acid desaturase enzyme activity measurement

PDXDC1 FADS2

1.72e-048742EFO_0009791
Diseaseblindness (implicated_via_orthology)

PNPLA7 MYO15A

1.72e-048742DOID:1432 (implicated_via_orthology)
Diseaselevel of Phosphatidylcholine (O-18:1_20:3) in blood serum

PDXDC1 FADS2

2.21e-049742OBA_2045130
Disease1-stearoyl-2-arachidonoyl-GPC (18:0/20:4) measurement

PDXDC1 FADS2

2.21e-049742EFO_0800271
Diseaselevel of Phosphatidylcholine (16:0_20:3) in blood serum

PDXDC1 FADS2

2.76e-0410742OBA_2045075
Diseaselevel of Phosphatidylinositol (16:0_18:1) in blood serum

PDXDC1 FADS2

4.03e-0412742OBA_2045152
Diseaselevel of Phosphatidylcholine (O-16:0_20:3) in blood serum

PDXDC1 FADS2

4.03e-0412742OBA_2045115
Diseaselevel of Phosphatidylinositol (18:0_20:3) in blood serum

PDXDC1 FADS2

4.03e-0412742OBA_2045157
Diseasedihomo-linolenoylcarnitine (C20:3n3 or 6) measurement

PDXDC1 FADS2

4.75e-0413742EFO_0800547
Diseasephosphatidylcholine 40:7 measurement

PDXDC1 FADS2

4.75e-0413742EFO_0021477
Diseaseneurodegenerative disease (implicated_via_orthology)

TARDBP DVL1P1 DVL1 PNPLA7

4.93e-04145744DOID:1289 (implicated_via_orthology)
Disease1-stearoyl-2-dihomo-linolenoyl-GPI (18:0/20:3n3 or 6) measurement

PDXDC1 FADS2

5.54e-0414742EFO_0022085
Diseaseproliferative diabetic retinopathy (is_marker_for)

ADIPOQ MAP3K8

7.28e-0416742DOID:13207 (is_marker_for)
Diseaselevel of Phosphatidylcholine (18:0_20:3) in blood serum

PDXDC1 FADS2

7.28e-0416742OBA_2045093
Diseasemetabolite measurement, diet measurement

PDXDC1 FADS2 PDXDC2P

7.66e-0471743EFO_0004725, EFO_0008111
Diseasetriacylglycerol 56:3 measurement

FADS2 BCAT1

9.25e-0418742EFO_0010430
Diseaselevel of Phosphatidylcholine (15:0_18:2) in blood serum

PDXDC1 FADS2

9.25e-0418742OBA_2045065
DiseaseManic

PACS1 PREP FADS2

1.01e-0378743C0338831
Diseaselevel of Sterol ester (27:1/20:3) in blood serum

PDXDC1 FADS2

1.03e-0319742OBA_2045199
Diseaselevel of Phosphatidylcholine (16:0_18:2) in blood serum

PDXDC1 FADS2

1.14e-0320742OBA_2045071
Diseasecoronary atherosclerosis measurement, traffic air pollution measurement

DOCK1 RARS2

1.26e-0321742EFO_0007908, EFO_0007938
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, lipid measurement

PDXDC1 FADS2 CSGALNACT1

1.78e-0395743EFO_0004529, EFO_0008317, EFO_0008596
Diseasealpha-linolenic acid measurement

PDXDC1 FADS2

1.79e-0325742EFO_0007759
Diseasechylomicron measurement, triglyceride measurement, very low density lipoprotein cholesterol measurement

PDXDC1 FADS2 CSGALNACT1

1.83e-0396743EFO_0004530, EFO_0008317, EFO_0008596
Diseasephosphatidylcholine 38:4 measurement

PDXDC1 FADS2

2.25e-0328742EFO_0010386
Diseaselevel of Phosphatidylethanolamine (18:0_18:2) in blood serum

PDXDC1 FADS2

2.25e-0328742OBA_2045139
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement

PDXDC1 FADS2 CSGALNACT1

2.43e-03106743EFO_0008317, EFO_0008596

Protein segments in the cluster

PeptideGeneStartEntry
EWGVYTIIEDLHGAG

UMODL1

1096

Q5DID0
FHLILEYQAGEEWGQ

ADPGK

206

Q9BRR6
YHDEGWVAILLGFLV

CNTNAP1

1276

P78357
DYLDWEVGVHGIRIE

AMMECR1L

206

Q6DCA0
LYIAWAGHLEAQGEL

BUB1

101

O43683
LWLYGEDHQITEVGT

BCAT1

246

P54687
LDIKGWGGEDVHLYR

CSGALNACT1

441

Q8TDX6
EVGDQVWLQVYGEGE

ADIPOQ

206

Q15848
DAEGHLIYHVGDWLQ

CLK2

146

P49760
WLYEQIEIEGGEIIH

ARL14EP

241

Q8N8R7
WVNGVDTVEHEGGYL

GUSBP11

136

Q6P575
IDYTVLDDVGHGVKW

ABI1

141

Q8IZP0
YGLEHWGSDTQGVEK

DUS3L

556

Q96G46
YLDVGWGLGSVTHEL

AOC1

371

P19801
AGRVEIYHDGFWGTI

CD163L1

1046

Q9NR16
LHGHWGLGQVVTDYV

SDHD

101

O14521
LNGEGHVFVWGYGIL

RCC1L

351

Q96I51
QGGLYEAIAGHWIQV

P3H3

276

Q8IVL6
VIAWAESHIEIYGGA

NPTX1

406

Q15818
GELVVYQREAGHFWD

ARHGEF17

1791

Q96PE2
LHVFVLGEWQPIEYG

FADS2

236

O95864
GLHSENREDEGWQVY

MISP

81

Q8IVT2
ELGLFGVWAHNGEVR

PCDHB13

611

Q9Y5F0
EGAVEVKYEGHWRQV

LOXL4

176

Q96JB6
GIGIENIHYLNDGLW

MCTS1

161

Q9ULC4
GIGIENIHYLNDGLW

MCTS2

161

A0A3B3IRV3
GVYDGEEHSVFGEPW

MAGEB2

231

O15479
LFGVVWYLVAVAHGD

KCNJ10

81

P78508
GVQWAELAGHDYVLD

MYO15A

2271

Q9UKN7
LWGLVHDFVVGQQEG

MMS19

16

Q96T76
LGDTLIDGGEHYWEV

FSD1

346

Q9BTV5
NVGSVEGLAYHRGWD

LRP1

2281

Q07954
VQEYVVEWRELHPGG

IL12RB2

451

Q99665
VWDYNEGEVTHVGVG

CFAP52

571

Q8N1V2
RHENIAELYGAVLWG

MAP3K8

186

P41279
AELYGAVLWGETVHL

MAP3K8

191

P41279
IVGGGCLVLEYWRHQ

OPA3

91

Q9H6K4
VGQDGGVYEGVGWHI

PGLYRP3

246

Q96LB9
RVYEGVGWNIQGVHT

PGLYRP4

126

Q96LB8
EQYGIWLHVEGVNLA

PDXDC1

261

Q6P996
EQYGIWLHVEGVNLA

PDXDC2P

261

Q6P474
EEGWLYGVVSHQDSI

KDM3B

211

Q7LBC6
AGAVDVVRHWQDLGY

PITPNM2

1131

Q9BZ72
EVGYQHGRTVFDIWG

PNPLA7

1191

Q6ZV29
YGDVIGLQVDYWLGH

PACS1

816

Q6VY07
VANIRGGGEYGETWH

PREP

501

P48147
AGQGQIYVHLTDGIW

GMPPA

231

Q96IJ6
HVGEEEEDTNLWIGY

TTC26

51

A0AVF1
QIGDTVHILETYEGW

DOCK1

31

Q14185
EQWEVRHGGLLGIKY

BTAF1

401

O14981
IHYGIIDNDGGWVDI

CRISPLD1

341

Q9H336
RDGWIVDYIHIFGQG

C17orf98

76

A8MV24
IWHYPGEEVNAGRIG

FLVCR2

336

Q9UPI3
GEVVLPAWYTLHGEV

ESAM

46

Q96AP7
ILYIIGAHGGETSWV

MAL

71

P21145
GYIVLGLVAWVHGDP

SLC44A5

51

Q8NCS7
IGADVVDWLYTHVEG

DVL1

446

O14640
IGADVVDWLYTHVEG

DVL1P1

421

P54792
HVIAWQQGEYGEFVI

ETV3L

56

Q6ZN32
HVGTWHEGVLNIDDY

GRM1

496

Q13255
AAIGLYLWEHIFEGL

RXYLT1

106

Q9Y2B1
TIEGEWFYGPVDLHV

CFAP47

2351

Q6ZTR5
LGHQVIRINYLGDWG

RARS2

161

Q5T160
HWGNEEIGLLLAEAY

TBC1D22B

476

Q9NU19
LHAPDAGWGNLVYVV

TARDBP

61

Q13148
EVVEVGHFWGYRIDE

TDRD9

906

Q8NDG6
WGYCLTQVVGGHLGD

SLC17A9

71

Q9BYT1
DAVSWQDYLGGIIQH

CTSO

246

P43234
EAADVWYNLGHVAVG

TTC8

421

Q8TAM2
GAHIIVTPEDAIYGW

VNN1

71

O95497
DGEDLAGQPWYHGLL

SH2D3A

6

Q9BRG2
GWNTYLVDGHDVEAL

TKTL2

211

Q9H0I9
GVIQVVWGCDQGHDY

ZNF276

226

Q8N554
EAEGELSEGEHWYGN

ZNF827

21

Q17R98
RDLGDEYGWKQVHGD

TM9SF3

266

Q9HD45
GGVYPEVLFEVAHQW

ZSWIM8

1406

A7E2V4
AQIWLHAAEVYIGIG

TTC7B

696

Q86TV6
EHGVWLIGLKEGRVY

TRIM50

381

Q86XT4
VGEGAYRWAVDHGIP

TASP1

166

Q9H6P5
HYWEVLVGEGAEWGL

TRIM58

346

Q8NG06