Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionfatty acid elongase activity

ELOVL4 ELOVL6 ELOVL2

1.57e-077343GO:0009922
GeneOntologyMolecularFunctionphosphoric diester hydrolase activity

PLCB2 PDE7A PDE10A

5.96e-0497343GO:0008081
GeneOntologyMolecularFunction3',5'-cyclic-AMP phosphodiesterase activity

PDE7A PDE10A

6.36e-0422342GO:0004115
GeneOntologyMolecularFunction3',5'-cyclic-GMP phosphodiesterase activity

PDE7A PDE10A

7.59e-0424342GO:0047555
GeneOntologyMolecularFunction3',5'-cyclic-nucleotide phosphodiesterase activity

PDE7A PDE10A

8.24e-0425342GO:0004114
GeneOntologyMolecularFunctioncyclic-nucleotide phosphodiesterase activity

PDE7A PDE10A

9.62e-0427342GO:0004112
GeneOntologyMolecularFunctiondynein complex binding

HDAC6 FBXW11

1.03e-0328342GO:0070840
GeneOntologyMolecularFunctionbeta-tubulin binding

HDAC6 TTLL7

3.15e-0349342GO:0048487
GeneOntologyMolecularFunctionligase activity

ACACB BTRC TTLL7

3.19e-03174343GO:0016874
GeneOntologyMolecularFunctionalpha-tubulin binding

HDAC6 TTLL7

3.54e-0352342GO:0043014
GeneOntologyBiologicalProcessfatty acid elongation, polyunsaturated fatty acid

ELOVL4 ELOVL6 ELOVL2

1.43e-077343GO:0034626
GeneOntologyBiologicalProcessfatty acid elongation, monounsaturated fatty acid

ELOVL4 ELOVL6 ELOVL2

1.43e-077343GO:0034625
GeneOntologyBiologicalProcessfatty acid elongation, unsaturated fatty acid

ELOVL4 ELOVL6 ELOVL2

1.43e-077343GO:0019368
GeneOntologyBiologicalProcessfatty acid elongation, saturated fatty acid

ELOVL4 ELOVL6 ELOVL2

2.28e-078343GO:0019367
GeneOntologyBiologicalProcessvery long-chain fatty acid biosynthetic process

ELOVL4 ELOVL6 ELOVL2

1.16e-0613343GO:0042761
GeneOntologyBiologicalProcessthioester biosynthetic process

ELOVL4 ELOVL6 ACACB ELOVL2

1.24e-0649344GO:0035384
GeneOntologyBiologicalProcessacyl-CoA biosynthetic process

ELOVL4 ELOVL6 ACACB ELOVL2

1.24e-0649344GO:0071616
GeneOntologyBiologicalProcessfatty acid elongation

ELOVL4 ELOVL6 ELOVL2

1.84e-0615343GO:0030497
GeneOntologyBiologicalProcessribonucleoside bisphosphate biosynthetic process

ELOVL4 ELOVL6 ACACB ELOVL2

3.00e-0661344GO:0034030
GeneOntologyBiologicalProcesspurine nucleoside bisphosphate biosynthetic process

ELOVL4 ELOVL6 ACACB ELOVL2

3.00e-0661344GO:0034033
GeneOntologyBiologicalProcessnucleoside bisphosphate biosynthetic process

ELOVL4 ELOVL6 ACACB ELOVL2

3.00e-0661344GO:0033866
GeneOntologyBiologicalProcesslong-chain fatty-acyl-CoA biosynthetic process

ELOVL4 ELOVL6 ELOVL2

3.89e-0619343GO:0035338
GeneOntologyBiologicalProcesslong-chain fatty-acyl-CoA metabolic process

ELOVL4 ELOVL6 ELOVL2

1.17e-0527343GO:0035336
GeneOntologyBiologicalProcessfatty-acyl-CoA biosynthetic process

ELOVL4 ELOVL6 ELOVL2

1.17e-0527343GO:0046949
GeneOntologyBiologicalProcessvery long-chain fatty acid metabolic process

ELOVL4 ELOVL6 ELOVL2

2.58e-0535343GO:0000038
GeneOntologyBiologicalProcessthioester metabolic process

ELOVL4 ELOVL6 ACACB ELOVL2

3.03e-05109344GO:0035383
GeneOntologyBiologicalProcessacyl-CoA metabolic process

ELOVL4 ELOVL6 ACACB ELOVL2

3.03e-05109344GO:0006637
GeneOntologyBiologicalProcessfatty-acyl-CoA metabolic process

ELOVL4 ELOVL6 ELOVL2

4.50e-0542343GO:0035337
GeneOntologyBiologicalProcesspurine nucleoside bisphosphate metabolic process

ELOVL4 ELOVL6 ACACB ELOVL2

8.50e-05142344GO:0034032
GeneOntologyBiologicalProcessnucleoside bisphosphate metabolic process

ELOVL4 ELOVL6 ACACB ELOVL2

8.50e-05142344GO:0033865
GeneOntologyBiologicalProcessribonucleoside bisphosphate metabolic process

ELOVL4 ELOVL6 ACACB ELOVL2

8.50e-05142344GO:0033875
GeneOntologyBiologicalProcessfatty acid derivative biosynthetic process

ELOVL4 ELOVL6 ELOVL2

8.56e-0552343GO:1901570
GeneOntologyBiologicalProcesscAMP catabolic process

PDE7A PDE10A

9.43e-059342GO:0006198
GeneOntologyBiologicalProcessunsaturated fatty acid biosynthetic process

ELOVL4 ELOVL6 ELOVL2

1.07e-0456343GO:0006636
GeneOntologyBiologicalProcessprotein destabilization

HDAC6 BTRC FBXW11

1.07e-0456343GO:0031648
GeneOntologyBiologicalProcesspurine ribonucleotide metabolic process

ELOVL4 ELOVL6 PDE7A PDE10A ACACB ELOVL2

1.69e-04512346GO:0009150
GeneOntologyBiologicalProcessamide biosynthetic process

ELOVL4 ELOVL6 ACACB ELOVL2

1.78e-04172344GO:0043604
GeneOntologyBiologicalProcesssulfur compound biosynthetic process

ELOVL4 ELOVL6 ACACB ELOVL2

2.03e-04178344GO:0044272
GeneOntologyBiologicalProcessribonucleotide metabolic process

ELOVL4 ELOVL6 PDE7A PDE10A ACACB ELOVL2

2.10e-04533346GO:0009259
GeneOntologyBiologicalProcessribose phosphate metabolic process

ELOVL4 ELOVL6 PDE7A PDE10A ACACB ELOVL2

2.26e-04540346GO:0019693
GeneOntologyBiologicalProcesscyclic nucleotide catabolic process

PDE7A PDE10A

2.37e-0414342GO:0009214
GeneOntologyBiologicalProcesscAMP-mediated signaling

SCTR PDE7A PDE10A

2.65e-0476343GO:0019933
GeneOntologyBiologicalProcessfatty acid biosynthetic process

ELOVL4 ELOVL6 ACACB ELOVL2

2.66e-04191344GO:0006633
GeneOntologyBiologicalProcessfatty acid derivative metabolic process

ELOVL4 ELOVL6 ELOVL2

3.32e-0482343GO:1901568
GeneOntologyBiologicalProcesspurine nucleotide metabolic process

ELOVL4 ELOVL6 PDE7A PDE10A ACACB ELOVL2

4.68e-04619346GO:0006163
GeneOntologyBiologicalProcesspurine ribonucleotide biosynthetic process

ELOVL4 ELOVL6 ACACB ELOVL2

5.55e-04232344GO:0009152
GeneOntologyBiologicalProcesspurine-containing compound metabolic process

ELOVL4 ELOVL6 PDE7A PDE10A ACACB ELOVL2

6.16e-04652346GO:0072521
GeneOntologyBiologicalProcessribonucleotide biosynthetic process

ELOVL4 ELOVL6 ACACB ELOVL2

7.02e-04247344GO:0009260
GeneOntologyBiologicalProcessribose phosphate biosynthetic process

ELOVL4 ELOVL6 ACACB ELOVL2

7.68e-04253344GO:0046390
GeneOntologyBiologicalProcesscAMP metabolic process

PDE7A PDE10A

7.73e-0425342GO:0046058
GeneOntologyBiologicalProcessnucleotide metabolic process

ELOVL4 ELOVL6 PDE7A PDE10A ACACB ELOVL2

7.92e-04684346GO:0009117
GeneOntologyBiologicalProcessnucleoside phosphate metabolic process

ELOVL4 ELOVL6 PDE7A PDE10A ACACB ELOVL2

8.35e-04691346GO:0006753
GeneOntologyBiologicalProcessmonocarboxylic acid biosynthetic process

ELOVL4 ELOVL6 ACACB ELOVL2

8.50e-04260344GO:0072330
GeneOntologyBiologicalProcesssphingolipid biosynthetic process

ELOVL4 ELOVL6 ELOVL2

9.36e-04117343GO:0030148
GeneOntologyBiologicalProcesspositive regulation of circadian rhythm

BTRC FBXW11

1.11e-0330342GO:0042753
GeneOntologyBiologicalProcesspurine nucleotide biosynthetic process

ELOVL4 ELOVL6 ACACB ELOVL2

1.12e-03280344GO:0006164
GeneOntologyBiologicalProcessunsaturated fatty acid metabolic process

ELOVL4 ELOVL6 ELOVL2

1.21e-03128343GO:0033559
GeneOntologyBiologicalProcesspurine-containing compound biosynthetic process

ELOVL4 ELOVL6 ACACB ELOVL2

1.24e-03288344GO:0072522
GeneOntologyBiologicalProcessprotein polyubiquitination

THOP1 HDAC6 BTRC FBXW11

1.26e-03289344GO:0000209
GeneOntologyBiologicalProcessnucleobase-containing small molecule metabolic process

ELOVL4 ELOVL6 PDE7A PDE10A ACACB ELOVL2

1.43e-03767346GO:0055086
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol

PLCB2 DMD ITPR2

1.77e-03146343GO:0051209
GeneOntologyBiologicalProcessnegative regulation of sequestering of calcium ion

PLCB2 DMD ITPR2

1.81e-03147343GO:0051283
GeneOntologyBiologicalProcessnucleotide biosynthetic process

ELOVL4 ELOVL6 ACACB ELOVL2

1.81e-03319344GO:0009165
GeneOntologyBiologicalProcessnucleoside phosphate biosynthetic process

ELOVL4 ELOVL6 ACACB ELOVL2

1.83e-03320344GO:1901293
GeneOntologyBiologicalProcessregulation of sequestering of calcium ion

PLCB2 DMD ITPR2

1.88e-03149343GO:0051282
GeneOntologyBiologicalProcessestablishment of mitotic spindle orientation

ZW10 FBXW11

1.88e-0339342GO:0000132
GeneOntologyBiologicalProcessregulation of cAMP-mediated signaling

SCTR PDE10A

1.98e-0340342GO:0043949
GeneOntologyBiologicalProcesssequestering of calcium ion

PLCB2 DMD ITPR2

2.02e-03153343GO:0051208
GeneOntologyBiologicalProcessmembrane lipid biosynthetic process

ELOVL4 ELOVL6 ELOVL2

2.18e-03157343GO:0046467
GeneOntologyBiologicalProcessorganophosphate metabolic process

ELOVL4 PLCB2 ELOVL6 PDE7A PDE10A ACACB ELOVL2

2.26e-031142347GO:0019637
GeneOntologyBiologicalProcessnucleus localization

DMD FBXW11

2.39e-0344342GO:0051647
GeneOntologyBiologicalProcessestablishment of mitotic spindle localization

ZW10 FBXW11

2.39e-0344342GO:0040001
GeneOntologyBiologicalProcesscyclic purine nucleotide metabolic process

PDE7A PDE10A

2.39e-0344342GO:0052652
GeneOntologyBiologicalProcesscyclic nucleotide metabolic process

PDE7A PDE10A

2.50e-0345342GO:0009187
GeneOntologyBiologicalProcessestablishment of spindle orientation

ZW10 FBXW11

2.61e-0346342GO:0051294
GeneOntologyBiologicalProcesssulfur compound metabolic process

ELOVL4 ELOVL6 ACACB ELOVL2

2.94e-03365344GO:0006790
GeneOntologyBiologicalProcessSCF-dependent proteasomal ubiquitin-dependent protein catabolic process

BTRC FBXW11

2.95e-0349342GO:0031146
GeneOntologyBiologicalProcesssphingolipid metabolic process

ELOVL4 ELOVL6 ELOVL2

3.01e-03176343GO:0006665
GeneOntologyBiologicalProcesscarboxylic acid biosynthetic process

ELOVL4 ELOVL6 ACACB ELOVL2

3.21e-03374344GO:0046394
GeneOntologyBiologicalProcessorganic acid biosynthetic process

ELOVL4 ELOVL6 ACACB ELOVL2

3.30e-03377344GO:0016053
DomainELO_CS

ELOVL4 ELOVL6 ELOVL2

1.10e-076343IPR030457
DomainELO

ELOVL4 ELOVL6 ELOVL2

1.92e-077343PF01151
DomainELO

ELOVL4 ELOVL6 ELOVL2

1.92e-077343PS01188
DomainELO_fam

ELOVL4 ELOVL6 ELOVL2

1.92e-077343IPR002076
DomainBeta-TrCP_D

BTRC FBXW11

3.22e-062342IPR021977
DomainBeta-TrCP_D

BTRC FBXW11

3.22e-062342PF12125
DomainBeta-TrCP_D

BTRC FBXW11

3.22e-062342SM01028
DomainGPCR_2_VIP_rcpt_1

SCTR VIPR1

9.64e-063342IPR001771
DomainATP_grasp_subdomain_1

ACACB TTLL7

4.83e-0418342IPR013815
DomainPDEase

PDE7A PDE10A

5.39e-0419342IPR023088
DomainPDEase_I

PDE7A PDE10A

6.61e-0421342PF00233
DomainPDEASE_I

PDE7A PDE10A

6.61e-0421342PS00126
DomainPDEase_CS

PDE7A PDE10A

6.61e-0421342IPR023174
Domain-

PDE7A PDE10A

7.26e-04223421.10.1300.10
DomainPDEase_catalytic_dom

PDE7A PDE10A

7.95e-0423342IPR002073
DomainHDc

PDE7A PDE10A

8.66e-0424342SM00471
DomainHD/PDEase_dom

PDE7A PDE10A

8.66e-0424342IPR003607
DomainHormR

SCTR VIPR1

9.40e-0425342SM00008
DomainHRM

SCTR VIPR1

1.18e-0328342PF02793
DomainATP_grasp_subdomain_2

ACACB TTLL7

1.45e-0331342IPR013816
DomainGPCR_2_secretin-like_CS

SCTR VIPR1

1.74e-0334342IPR017983
DomainG_PROTEIN_RECEP_F2_1

SCTR VIPR1

2.40e-0340342PS00649
DomainG_PROTEIN_RECEP_F2_3

SCTR VIPR1

2.40e-0340342PS50227
DomainGPCR_2_extracellular_dom

SCTR VIPR1

2.40e-0340342IPR001879
DomainF-box-like

BTRC FBXW11

2.90e-0344342PF12937
DomainG_PROTEIN_RECEP_F2_2

SCTR VIPR1

3.73e-0350342PS00650
Domain7tm_2

SCTR VIPR1

3.73e-0350342PF00002
DomainFBOX

BTRC FBXW11

4.03e-0352342SM00256
DomainGPCR_2-like

SCTR VIPR1

5.33e-0360342IPR017981
DomainGPCR_2_secretin-like

SCTR VIPR1

5.33e-0360342IPR000832
DomainG_PROTEIN_RECEP_F2_4

SCTR VIPR1

5.50e-0361342PS50261
DomainF-box

BTRC FBXW11

6.60e-0367342PF00646
DomainFBOX

BTRC FBXW11

7.59e-0372342PS50181
DomainF-box_dom

BTRC FBXW11

8.21e-0375342IPR001810
DomainG-protein_beta_WD-40_rep

BTRC FBXW11

1.04e-0285342IPR020472
PathwayWP_ELONGATION_OF_VERY_LONG_CHAIN_FATTY_ACIDS

ELOVL4 ELOVL6 ELOVL2

1.53e-0612283MM17077
PathwayWP_ECTODERM_DIFFERENTIATION

ELOVL4 DMD HDAC6 PDE7A ELOVL2

7.88e-06142285M39575
PathwayREACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS

ELOVL4 ELOVL6 ELOVL2

1.38e-0524283M1016
PathwayREACTOME_FATTY_ACYL_COA_BIOSYNTHESIS

ELOVL4 ELOVL6 ELOVL2

5.21e-0537283M729
PathwayKEGG_MEDICUS_PATHOGEN_SHIGELLA_OSPG_TO_TNF_NFKB_SIGNALING_PATHWAY

BTRC FBXW11

7.94e-057282M47653
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

PLCB2 ITPR2

1.70e-0410282M47661
PathwayREACTOME_G_ALPHA_S_SIGNALLING_EVENTS

SCTR VIPR1 PDE7A PDE10A

1.72e-04143284MM15055
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY

PLCB2 ITPR2

2.07e-0411282M49033
PathwayREACTOME_G_ALPHA_S_SIGNALLING_EVENTS

SCTR VIPR1 PDE7A PDE10A

2.46e-04157284M4904
PathwayKEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY

PLCB2 ITPR2

2.93e-0413282M47656
PathwayWP_OMEGA9_FATTY_ACID_SYNTHESIS

ELOVL6 ELOVL2

3.41e-0414282M39780
PathwayWP_OMEGA9_FATTY_ACID_SYNTHESIS

ELOVL6 ELOVL2

3.41e-0414282MM15840
PathwayREACTOME_FATTY_ACID_METABOLISM

ELOVL4 ELOVL6 ACACB ELOVL2

3.80e-04176284M27854
PathwayREACTOME_MAP3K8_TPL2_DEPENDENT_MAPK1_3_ACTIVATION

BTRC FBXW11

4.49e-0416282M27567
PathwayKEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY

PLCB2 ITPR2

7.07e-0420282M47688
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY

PLCB2 ITPR2

7.81e-0421282M47689
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

PLCB2 ITPR2

8.57e-0422282M47690
PathwayKEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY

PLCB2 ITPR2

8.57e-0422282M47675
PathwayREACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS

ELOVL6 ELOVL2

8.57e-0422282MM15451
PathwayKEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS

ELOVL6 ELOVL2

8.57e-0422282M11673
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

PLCB2 ITPR2

9.38e-0423282M47676
PathwayREACTOME_CLEC7A_DECTIN_1_SIGNALING

BTRC FBXW11 ITPR2

9.98e-04100283M27467
PathwayWP_GPCRS_CLASS_B_SECRETINLIKE

SCTR VIPR1

1.02e-0324282M39643
PathwayWP_GPCRS_CLASS_B_SECRETINLIKE

SCTR VIPR1

1.02e-0324282MM15992
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

PLCB2 ACACB ITPR2

1.25e-03108283M17034
PathwayKEGG_OOCYTE_MEIOSIS

BTRC FBXW11 ITPR2

1.42e-03113283M16817
PathwayREACTOME_SIGNALING_BY_GPCR

SCTR VIPR1 PLCB2 PDE7A PDE10A ITPR2

1.44e-03646286MM14962
PathwayREACTOME_FATTY_ACYL_COA_BIOSYNTHESIS

ELOVL6 ELOVL2

1.82e-0332282MM15446
PathwayREACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS

SCTR VIPR1

1.93e-0333282MM15066
PathwayREACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS

SCTR VIPR1

1.93e-0333282M10322
PathwayREACTOME_SIGNALING_BY_GPCR

SCTR VIPR1 PLCB2 PDE7A PDE10A ITPR2

2.19e-03702286M746
PathwayREACTOME_C_TYPE_LECTIN_RECEPTORS_CLRS

BTRC FBXW11 ITPR2

2.62e-03140283M27484
PathwayREACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP

ELOVL6 ACACB

3.12e-0342282M27172
PathwayKEGG_WNT_SIGNALING_PATHWAY

PLCB2 BTRC FBXW11

3.24e-03151283M19428
PathwayWP_RENINANGIOTENSINALDOSTERONE_SYSTEM_RAAS

PLCB2 ITPR2

3.42e-0344282M39845
Pubmed

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.

ELOVL4 ELOVL6 ELOVL2

1.02e-071034320937905
Pubmed

Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production.

ELOVL4 ELOVL6 ELOVL2

1.40e-071134323689133
Pubmed

Specificity, location and function of βTrCP isoforms and their splice variants.

BTRC FBXW11

9.28e-07234221138764
Pubmed

Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins.

ELOVL6 ELOVL2

9.28e-07234211567032
Pubmed

Mapping membrane lipids in the developing and adult mouse retina under physiological and pathological conditions using mass spectrometry.

ELOVL4 ELOVL2

9.28e-07234233465374
Pubmed

The characteristics and roles of β-TrCP1/2 in carcinogenesis.

BTRC FBXW11

9.28e-07234233021036
Pubmed

Differential dysregulation of β-TrCP1 and -2 by HIV-1 Vpu leads to inhibition of canonical and non-canonical NF-κB pathways in infected cells.

BTRC FBXW11

9.28e-07234237341489
Pubmed

Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.

ELOVL4 ELOVL6 ELOVL2

2.46e-062734325269881
Pubmed

Biosynthesis of triacylglycerols.

ELOVL4 ELOVL6 ELOVL2

2.75e-06283438944226
Pubmed

The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth.

BTRC FBXW11

2.78e-06334231406304
Pubmed

Silencing of both beta-TrCP1 and HOS (beta-TrCP2) is required to suppress human immunodeficiency virus type 1 Vpu-mediated CD4 down-modulation.

BTRC FBXW11

2.78e-06334217121803
Pubmed

Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase.

BTRC FBXW11

2.78e-06334223640883
Pubmed

Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase.

BTRC FBXW11

2.78e-06334228483528
Pubmed

Critical role for IL-1β in DNA damage-induced mucositis.

BTRC FBXW11

2.78e-06334224469832
Pubmed

Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor.

SCTR VIPR1

2.78e-0633428390245
Pubmed

The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2.

BTRC FBXW11

2.78e-06334218782782
Pubmed

Stability of Wake-Sleep Cycles Requires Robust Degradation of the PERIOD Protein.

BTRC FBXW11

2.78e-06334229103939
Pubmed

Persistent stimulation with interleukin-17 desensitizes cells through SCFβ-TrCP-mediated degradation of Act1.

BTRC FBXW11

2.78e-06334222045853
Pubmed

The ubiquitin ligase subunit β-TrCP in Sertoli cells is essential for spermatogenesis in mice.

BTRC FBXW11

2.78e-06334230391586
Pubmed

SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation.

BTRC FBXW11

2.78e-06334218354483
Pubmed

The Tumor Suppressor MIG6 Controls Mitotic Progression and the G2/M DNA Damage Checkpoint by Stabilizing the WEE1 Kinase.

BTRC FBXW11

5.56e-06434230067982
Pubmed

β-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress.

BTRC FBXW11

5.56e-06434230031111
Pubmed

Oxidative stress-induced ubiquitination of RCAN1 mediated by SCFbeta-TrCP ubiquitin ligase.

BTRC FBXW11

5.56e-06434218575781
Pubmed

S6 Kinase- and β-TrCP2-Dependent Degradation of p19Arf Is Required for Cell Proliferation.

BTRC FBXW11

5.56e-06434226240281
Pubmed

Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase.

BTRC FBXW11

5.56e-06434216651270
Pubmed

SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response.

BTRC FBXW11

5.56e-06434216885022
Pubmed

Long noncoding RNA UPAT promotes colon tumorigenesis by inhibiting degradation of UHRF1.

BTRC FBXW11

5.56e-06434226768845
Pubmed

Multiple isoforms of beta-TrCP display differential activities in the regulation of Wnt signaling.

BTRC FBXW11

5.56e-06434218929646
Pubmed

PLK1 and β-TrCP-dependent ubiquitination and degradation of Rap1GAP controls cell proliferation.

BTRC FBXW11

5.56e-06434225329897
Pubmed

Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis.

BTRC FBXW11

5.56e-06434219270156
Pubmed

SCFβ(TrCP) mediates stress-activated MAPK-induced Cdc25B degradation.

BTRC FBXW11

9.26e-06534221807946
Pubmed

Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing.

BTRC FBXW11

9.26e-06534214673179
Pubmed

Regulation of mitosis-meiosis transition by the ubiquitin ligase β-TrCP in male germ cells.

BTRC FBXW11

9.26e-06534228982686
Pubmed

Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9.

BTRC FBXW11

9.26e-06534225190485
Pubmed

Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner.

BTRC FBXW11

9.26e-06534215798217
Pubmed

Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway.

MOB1A HDAC6

9.26e-06534235349706
Pubmed

Revealing β-TrCP activity dynamics in live cells with a genetically encoded biosensor.

BTRC FBXW11

9.26e-06534236289220
Pubmed

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.

BTRC FBXW11

9.26e-06534214681206
Pubmed

IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2.

BTRC FBXW11

9.26e-06534210066435
Pubmed

ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis.

CHCHD3 HDAC6 ZW10 ELOVL2 ITPR2

1.03e-0529934537931956
Pubmed

Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination.

BTRC FBXW11

1.39e-05634210644755
Pubmed

TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex.

BTRC FBXW11

1.39e-05634217636028
Pubmed

SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection.

BTRC FBXW11

1.39e-05634217217622
Pubmed

Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization.

BTRC FBXW11

1.39e-05634217387146
Pubmed

Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha.

BTRC FBXW11

1.39e-05634211158290
Pubmed

Fas-associated factor 1 is a scaffold protein that promotes β-transducin repeat-containing protein (β-TrCP)-mediated β-catenin ubiquitination and degradation.

BTRC FBXW11

1.39e-05634222730322
Pubmed

betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.

BTRC FBXW11

1.39e-05634212482991
Pubmed

Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis.

BTRC FBXW11

1.39e-05634218056411
Pubmed

The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival.

BTRC FBXW11

1.39e-05634219966869
Pubmed

USP17- and SCFβTrCP--regulated degradation of DEC1 controls the DNA damage response.

BTRC FBXW11

1.94e-05734225202122
Pubmed

The p97-UFD1L-NPL4 protein complex mediates cytokine-induced IκBα proteolysis.

BTRC FBXW11

1.94e-05734224248593
Pubmed

Identification of substrates for F-box proteins.

BTRC FBXW11

1.94e-05734216338364
Pubmed

Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome.

PLCB2 DMD

1.94e-05734221115837
Pubmed

ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4.

BTRC FBXW11

1.94e-05734222307056
Pubmed

The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding.

BTRC FBXW11

1.94e-05734230143532
Pubmed

betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.

BTRC FBXW11

2.59e-05834219150432
Pubmed

SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2.

BTRC FBXW11

2.59e-05834222711876
Pubmed

Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress.

BTRC FBXW11

2.59e-05834222669845
Pubmed

SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.

BTRC FBXW11

2.59e-05834215917222
Pubmed

mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR.

BTRC FBXW11

2.59e-05834222017877
Pubmed

Proteasome-dependent degradation of transcription factor activating enhancer-binding protein 4 (TFAP4) controls mitotic division.

BTRC FBXW11

2.59e-05834224500709
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

ZNF624 CHCHD3 THOP1 HDAC6 PDE7A BTRC FBXW11 ASH1L

2.62e-05128534835914814
Pubmed

CENP-W inhibits CDC25A degradation by destabilizing the SCFβ-TrCP-1 complex at G2/M.

BTRC FBXW11

3.33e-05934229863914
Pubmed

DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy.

BTRC FBXW11

3.33e-05934222017876
Pubmed

Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.

BTRC FBXW11

3.33e-05934220708156
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

MOB1A CHCHD3 THOP1 DMD TNPO3 BTRC FBXW11

3.67e-0597434728675297
Pubmed

β-TrCP-mediated IRAK1 degradation releases TAK1-TRAF6 from the membrane to the cytosol for TAK1-dependent NF-κB activation.

BTRC FBXW11

4.15e-051034222851693
Pubmed

NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach.

BTRC FBXW11

4.15e-051034215485837
Pubmed

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.

BTRC FBXW11

4.15e-051034214603323
Pubmed

Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.

SCTR VIPR1

4.15e-051034215670850
Pubmed

Cyclin F-Dependent Degradation of RBPJ Inhibits IDH1R132H-Mediated Tumorigenesis.

BTRC FBXW11

5.07e-051134230254149
Pubmed

Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination.

BTRC FBXW11

5.07e-051134224912152
Pubmed

Polyubiquitination of the B-cell translocation gene 1 and 2 proteins is promoted by the SCF ubiquitin ligase complex containing βTrCP.

BTRC FBXW11

5.07e-051134222975506
Pubmed

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.

BTRC FBXW11

6.08e-051234218662541
Pubmed

Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.

BTRC FBXW11

6.08e-051234222682247
Pubmed

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase.

BTRC FBXW11

6.08e-051234224785407
Pubmed

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis.

BTRC FBXW11

6.08e-051234218354482
Pubmed

S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer.

BTRC FBXW11

7.19e-051334229507620
Pubmed

TAK1 Is a Novel Target in Hepatocellular Carcinoma and Contributes to Sorafenib Resistance.

BTRC FBXW11

7.19e-051334233962073
Pubmed

The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression.

TASOR BTRC FBXW11

7.70e-058434326299517
Pubmed

A central role for regulated protein stability in the control of TFE3 and MITF by nutrients.

BTRC FBXW11

8.38e-051434236608670
Pubmed

Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.

PLCB2 ITPR2

9.66e-051534228578927
Pubmed

Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.

BTRC FBXW11

1.25e-041734217510365
Pubmed

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse.

PDE10A ELMOD1

1.25e-041734231171447
Pubmed

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.

BTRC FBXW11

1.41e-041834215070733
Pubmed

Serine Phosphorylation by mTORC1 Promotes IRS-1 Degradation through SCFβ-TRCP E3 Ubiquitin Ligase.

BTRC FBXW11

1.41e-041834230240640
Pubmed

RIPK4 activity in keratinocytes is controlled by the SCFβ-TrCP ubiquitin ligase to maintain cortical actin organization.

BTRC FBXW11

1.57e-041934229435596
Pubmed

¹H NMR metabolic profiling of plasma reveals additional phenotypes in knockout mouse models.

ELMOD1 BTRC

1.74e-042034225849460
Pubmed

FBXW7 Triggers Degradation of KMT2D to Favor Growth of Diffuse Large B-cell Lymphoma Cells.

BTRC FBXW11

1.74e-042034232350066
Pubmed

Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.

BTRC FBXW11

1.93e-042134237005481
Pubmed

HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure.

PLCB2 ITPR2

2.12e-042234231286141
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

MOB1A RETSAT BTRC CLK4 FBXW11 ITPR2

2.27e-0491034636736316
Pubmed

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.

BTRC FBXW11

2.32e-042334222017875
Pubmed

ATP-citrate lyase deficiency in the mouse.

ELOVL6 ACACB

2.32e-042334214662765
Pubmed

Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.

PLCB2 ITPR2

2.53e-042434210843712
Pubmed

Overview of PDEs and their regulation.

PDE7A PDE10A

2.74e-042534217307970
Pubmed

Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.

BTRC TTLL7

2.74e-042534229593216
Pubmed

Array MAPPIT: high-throughput interactome analysis in mammalian cells.

BTRC FBXW11

2.97e-042634219159283
Pubmed

C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.

BTRC FBXW11

3.21e-042734229420262
Pubmed

HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.

PDE7A PDE10A

3.21e-042734211156964
InteractionSTK4 interactions

MOB1A HDAC6 IGHG2 BTRC FBXW11

6.64e-06159345int:STK4
InteractionSKP1P2 interactions

BTRC FBXW11

8.28e-063342int:SKP1P2
InteractionLSP1 interactions

HDAC6 BTRC FBXW11

5.17e-0543343int:LSP1
InteractionFAM234A interactions

VIPR1 ZW10 TNPO3 ELOVL2

5.84e-05126344int:FAM234A
InteractionNRDC interactions

MOB1A ELAC2 BTRC FBXW11

6.40e-05129344int:NRDC
InteractionOPTN interactions

MOB1A CHCHD3 EPS8L2 THOP1 RETSAT ELAC2

6.66e-05422346int:OPTN
InteractionIFNLR1 interactions

SRBD1 BTRC FBXW11

7.67e-0549343int:IFNLR1
InteractionRCAN1 interactions

SRBD1 BTRC FBXW11

9.16e-0552343int:RCAN1
InteractionSCT interactions

SCTR VIPR1

9.87e-059342int:SCT
InteractionCD6 interactions

SRBD1 RETSAT BTRC FBXW11

1.27e-04154344int:CD6
Cytoband10q24.32

MFSD13A BTRC

1.45e-042434210q24.32
GeneFamilyWD repeat domain containing|F-box and WD repeat domain containing

BTRC FBXW11

5.72e-0511192559
GeneFamilyPhosphodiesterases

PDE7A PDE10A

2.85e-0424192681
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

CHCHD3 HDAC6

1.52e-02181192694
GeneFamilyWD repeat domain containing

BTRC FBXW11

3.04e-02262192362
CoexpressionGSE7568_IL4_VS_IL4_AND_DEXAMETHASONE_TREATED_MACROPHAGE_DN

VIPR1 PLCB2 PDE7A ITPR2 ASH1L

1.44e-06151345M369
CoexpressionBRUINS_UVC_RESPONSE_VIA_TP53_GROUP_D

ZNF624 PLCB2 DMD FBXW11 ITPR2

3.60e-05293345MM895
CoexpressionICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_DN

RETSAT ELAC2 ELOVL2

5.27e-0556343M13337
CoexpressionICHIBA_GRAFT_VERSUS_HOST_DISEASE_35D_DN

RETSAT ELAC2 ELOVL2

7.87e-0564343MM1257
CoexpressionGSE20727_CTRL_VS_DNFB_ALLERGEN_TREATED_DC_DN

MOB1A CHCHD3 EPS8L2 BTRC

1.13e-04194344M9249
CoexpressionBRUINS_UVC_RESPONSE_LATE

ZNF624 CHCHD3 USP17L10 EPS8L2 IQCH ZW10 RETSAT ITPR2

1.17e-041198348MM1062
CoexpressionGSE41867_NAIVE_VS_DAY15_LCMV_ARMSTRONG_EFFECTOR_CD8_TCELL_UP

CHCHD3 HDAC6 ELOVL6 TNPO3

1.28e-04200344M9499
CoexpressionGSE27786_BCELL_VS_NKTCELL_DN

VIPR1 SRBD1 ACACB RETSAT

1.28e-04200344M4809
CoexpressionGSE27786_LSK_VS_LIN_NEG_CELL_UP

PLCB2 HDAC6 ELOVL6 MFSD13A

1.28e-04200344M4739
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL6 ACACB RETSAT ELOVL2

7.42e-06165344d449a568664a81d9b5538e8f409301448a32ac37
ToppCellRA-11._Adipocyte|RA / Chamber and Cluster_Paper

ELOVL6 ACACB RETSAT ITPR2

1.05e-05180344d48a3d27357f7d184132a6805950f93080146b59
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MOB1A DMD PDE10A ASH1L

1.17e-05185344eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCellRA-11._Adipocyte|World / Chamber and Cluster_Paper

ELOVL6 ACACB RETSAT ITPR2

1.24e-051883444dac9d636e5cad4cda540b93d4bfed6b5732c880
ToppCellfacs-Tongue-nan-3m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL4 THOP1 ELMOD1 TTLL7

1.29e-05190344719a5cecc3e8001ca9c38165258b5ff9c800713a
ToppCellTracheal-10x3prime_v2-Immune_Lymphocytic-B-B_cell-B_naive|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SCTR PLCB2 HDAC6

6.25e-0510134386acaa2502f61baa714ae988b73e3e73a71e897e
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MOB1A VIPR1 EPS8L2

2.30e-04157343a426c54fd1545093d41426e9620862f71bd06f6b
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL6 RETSAT ELOVL2

2.35e-041583439f58428f70d1427b20122c5c1cc7bf521d0f4832
ToppCellnormal_Lung-B_lymphocytes-Undetermined|normal_Lung / Location, Cell class and cell subclass

ELOVL4 THOP1 IGHG2

2.39e-04159343f89fc18966d9b9b33e81e7b9eb3ec3420c20ff43
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ELOVL4 ELOVL2 TTLL7

2.48e-041613437d1bc73f4c82465b3f489d6737048b0cd54f22cf
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ELOVL4 ELOVL2 TTLL7

2.48e-04161343410eef62c83c704cbfc5a1b643c4db11bbdcd81f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ELOVL4 ELOVL2 TTLL7

2.48e-0416134371022485da6754a2b57b4c3e758e3de4c95cc292
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Neural-neural_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ELOVL4 ELOVL2 TTLL7

2.48e-0416134359ae8a7c9a04ecaa335b8064852a5a91a21780bd
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EPS8L2 PDE7A TTLL7

2.53e-0416234334b4cd3d2258f88dfbd6d32abd1db87aff8a6b6f
ToppCell5'-Adult-SmallIntestine-Epithelial-goblet-BEST2+_Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

THOP1 PDE10A MFSD13A

2.71e-041663430b4e1d879c61be9d18d7aac51e5115f103f51209
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL6 RETSAT ELOVL2

2.81e-04168343b98af4043dfa5dfa4413e482879fad88de484675
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL6 RETSAT ELOVL2

2.81e-04168343073b53d4cee6bc8c5c6fce51cf6cd9c316478f69
ToppCelldroplet-Liver-HEPATOCYTES|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL6 RETSAT ELOVL2

2.86e-04169343f195467438c589f87224bde7da720dea072d110c
ToppCelldroplet-Liver-HEPATOCYTES-1m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL6 RETSAT ELOVL2

2.86e-041693437785cab967a33560830c394c918d6ce625103858
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLCB2 ACACB ITPR2

2.91e-0417034317bd7fd25a2657cb536ad47e294332920f759e95
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SCTR DMD TTLL7

3.17e-04175343d52794426f2703a80e91ae0a8ff2d8e0ce4aa4a8
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SCTR DMD TTLL7

3.17e-04175343454f03e6109d65f5db08dbb41ecc19ffb6bbc4e0
ToppCellRV-11._Adipocyte|World / Chamber and Cluster_Paper

ACACB RETSAT ITPR2

3.27e-04177343f0edf04930692418953e4f00a917257804ec0ffd
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TASOR TTLL7 ASH1L

3.33e-0417834301dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellRV-11._Adipocyte|RV / Chamber and Cluster_Paper

ACACB RETSAT ITPR2

3.33e-04178343278bbea5cf8f0589f71675c7a3d00679391b5253
ToppCellfacs-Lung-24m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPS8L2 HDAC6 ACACB

3.44e-04180343baa5825e6ce23a98d9c21d024a4b0ab8ba353d0c
ToppCellBAL-Severe-Lymphocyte-B-B_cell|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PDE7A TASOR IGHG2

3.44e-04180343c3c72531af5b9f7a7416727fe609dab5180e03b6
ToppCellBAL-Severe-Lymphocyte-B-B_cell-B_cell-B_activate-7|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PDE7A TASOR IGHG2

3.44e-041803439f4bbaf6435c23e3e552ae22be8ea7884314192d
ToppCellfacs-Lung-24m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPS8L2 HDAC6 ACACB

3.44e-041803432d608b9394d28d19cfc85c6ac94003d5177c8a92
ToppCellBAL-Severe-Lymphocyte-B-B_cell-B_cell|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PDE7A TASOR IGHG2

3.44e-04180343b465f2f8b0e9a2034a4f1272bb00c77439164dbf
ToppCellfacs-Lung-24m-Endothelial-arterial_endothelial|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPS8L2 HDAC6 ACACB

3.44e-041803430f9b27054358c4737eed06c8ea01987cccc3cb55
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SCTR ACACB ITPR2

3.55e-04182343041bc819e6cf2618bf86bce8dfe2df673f392ba3
ToppCellLA-11._Adipocyte|World / Chamber and Cluster_Paper

ELOVL6 ACACB RETSAT

3.61e-04183343b177be283e1553fb1f69a346f1ba79ad00297fa2
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VIPR1 EPS8L2 DMD

3.61e-04183343351d575339038bd4a66f408da518c567444208e8
ToppCellLV-15._Ventricular_Cardiomyocyte_III|LV / Chamber and Cluster_Paper

DMD PDE7A ACACB

3.67e-04184343ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1-D122|Adult / Lineage, Cell type, age group and donor

EPS8L2 DMD TTLL7

3.67e-04184343561592edc3083fad41b91811151b442207c65dd9
ToppCellpdx-Tumor_cells-T0|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

DMD ACACB ITPR2

3.73e-041853431d874608aa2062024323512f68889219471b2f00
ToppCelldroplet-Tongue-nan-24m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL4 THOP1 TTLL7

3.79e-041863432913b5fd0617d024d600ba7015ec7b1961dade83
ToppCellhuman_hepatoblastoma-Tumor_cells-T2|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

DMD ACACB ITPR2

3.85e-04187343f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCelldroplet-Lung-nan-18m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL4 EPS8L2 TTLL7

3.91e-04188343405efea75233ecf70f7d19b630230798d817b7f2
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SCTR DMD TTLL7

3.91e-04188343a5e7a363fbd5ae4d9312cf6f9941413d6a5c0b4d
ToppCellfacs-Tongue-nan-24m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL4 THOP1 TTLL7

3.91e-04188343ed35e438796cef302b6787c111753425922792dc
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SCTR DMD TTLL7

3.97e-041893437fbe855bfdb47d35e040b04a80fe4b729a3764e8
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SCTR DMD TTLL7

3.97e-041893432cfb4d12f75678d1619f4743838a0e954bd57761
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SCTR DMD ELOVL2

3.97e-04189343975e7aa3b862a8b07c2ab8426a14f5cc54998aca
ToppCellRV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

DMD PDE7A ACACB

3.97e-041893435e80c47f63980904c4c1ff02c201b67b456a0974
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SCTR DMD TTLL7

3.97e-0418934306b35abecd29f902cf251fcc1f6ad33db7ab08a2
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SCTR DMD TTLL7

3.97e-04189343127ad2ba3e794df8cce2eee3e4171bccb5aad51b
ToppCellLV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

DMD PDE7A ACACB

4.03e-04190343de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DMD ELMOD1 TTLL7

4.03e-041903435681c211baeed4af82a2bbc13420f6a7b487581c
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DMD ELMOD1 TTLL7

4.03e-04190343f5fb989afabb49d64d91324570cd8c80a4b9e67d
ToppCelldroplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VIPR1 EPS8L2 DMD

4.03e-041903433cf464664d6aa22b212e60b70885953887e92483
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DMD ELMOD1 TTLL7

4.03e-04190343562ee3b025c29edf07b8b344323edb49d82f1c7e
ToppCellRV-06._Ventricular_Cardiomyocyte_II|RV / Chamber and Cluster_Paper

DMD PDE7A ACACB

4.03e-04190343fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TASOR ITPR2 ASH1L

4.09e-0419134360c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCellfacs-Tongue-nan-18m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL4 THOP1 TTLL7

4.09e-0419134302f24202f9fdd46c648265a5b3b6f9066aa009fc
ToppCellLV-06._Ventricular_Cardiomyocyte_II|LV / Chamber and Cluster_Paper

DMD PDE7A ACACB

4.09e-0419134325f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TASOR ITPR2 ASH1L

4.09e-04191343973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SCTR DMD TTLL7

4.15e-04192343b54b0d5b88139905521c8d5d58332e89c08d589c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SCTR DMD TTLL7

4.15e-04192343bfab13793e54de2550ee171397f7ece0625cdb4a
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SCTR EPS8L2 ITPR2

4.15e-04192343ee27d27e3d269764dbe8711d0b37ff9331a298a9
ToppCellfacs-Marrow-KLS-18m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THOP1 RETSAT MFSD13A

4.22e-04193343f92bbe70e6c725bfb8c08bfc2a94e375528151a3
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_neural-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PDE10A MFSD13A FEZF1

4.22e-04193343088c8b1e968f5356502347eaabdc6b1b1d4befd0
ToppCellfacs-Marrow-KLS-18m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THOP1 RETSAT MFSD13A

4.22e-0419334344ba79db566d0fa3bbcfe3adf9164bf8c3cb0bc3
ToppCelldroplet-Tongue-nan-3m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL4 THOP1 TTLL7

4.22e-04193343a7002acf3be76b2cc6fc9364176f6b0d3bd27d9c
ToppCell356C-Epithelial_cells-Epithelial-H_(AT1)-|356C / Donor, Lineage, Cell class and subclass (all cells)

HDAC6 RETSAT MFSD13A

4.28e-041943434c40d6b50675eae52c419d69e719a9223df02ae3
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL4 THOP1 TTLL7

4.28e-04194343a3adcdc8b87332e8beb9bcd70cf36424af10633d
ToppCell356C-Epithelial_cells-Epithelial-H_(AT1)|356C / Donor, Lineage, Cell class and subclass (all cells)

HDAC6 RETSAT MFSD13A

4.28e-0419434399a90de637e3babec2131cdd9f05ea965d8a8f30
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SCTR DMD TTLL7

4.28e-041943435c3b2b05d1e4f146551fe4c920263d8e6ca34de3
ToppCellRA-03._Atrial_Cardiomyocyte|RA / Chamber and Cluster_Paper

DMD PDE7A ACACB

4.28e-04194343c3535f7cc0076653c72db582047cff053c322397
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SCTR DMD TTLL7

4.28e-04194343ab9cad697f9209d2889bc02b43b502dfeb2ebfef
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DMD ELMOD1 ELOVL2

4.28e-0419434308fad7591c20568de797cf8e206de2d0b1d78aab
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HDAC6 TTLL7 ASH1L

4.35e-041953433e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HDAC6 TTLL7 ASH1L

4.35e-041953437796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellfacs-Marrow-KLS-3m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THOP1 RETSAT MFSD13A

4.41e-04196343c5adc95df9e1d1884a7988336e459a98c5a6769b
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-secretory_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF624 EPS8L2 BTRC

4.41e-04196343547901c7a665770eff78eede69b8625b416c8186
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF624 EPS8L2 BTRC

4.41e-041963436e08d7ba67da161c2dca1a17c440ffb9d9b5bc3b
ToppCellfacs-Marrow-KLS-3m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THOP1 RETSAT MFSD13A

4.41e-0419634381d1fd63397b2cf893607d828b61a926fa65185f
ToppCellLPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_only / Treatment groups by lineage, cell group, cell type

SCTR DMD ELOVL2

4.68e-042003437c62678cf408aaaf98d6df0fb27814d2007c4521
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

ELOVL4 VIPR1 PDE10A BTRC TTLL7

7.16e-061883353177_UP
DrugZimelidine dihydrochloride monohydrate [61129-30-4]; Down 200; 9.8uM; MCF7; HT_HG-U133A

ELOVL4 MOB1A MFSD13A BTRC ITPR2

8.76e-061963351512_DN
DrugIndoprofen [31842-01-0]; Up 200; 14.2uM; HL60; HT_HG-U133A

DMD ACACB BTRC TTLL7 ITPR2

8.98e-061973353007_UP
DrugEpitiostanol [2363-58-8]; Up 200; 13uM; HL60; HT_HG-U133A

DMD HDAC6 PDE10A ACACB ITPR2

8.98e-061973352922_UP
DrugAC1L4RIC

SCTR VIPR1

2.03e-055332CID000162562
Drug6-SA

BTRC FBXW11

3.04e-056332CID000449167
DiseaseMenkes disease (implicated_via_orthology)

BTRC FBXW11

1.29e-055342DOID:1838 (implicated_via_orthology)
Diseaseobesity (implicated_via_orthology)

PLCB2 HDAC6 ITPR2

1.93e-03215343DOID:9970 (implicated_via_orthology)
Diseasecongenital heart disease (implicated_via_orthology)

PLCB2 USP17L10

2.88e-0369342DOID:1682 (implicated_via_orthology)
Diseaseresponse to angiotensin-converting enzyme inhibitor

SRBD1 ELAC2

3.66e-0378342EFO_0005325
DiseaseCardiac Hypertrophy

DMD ITPR2

4.04e-0382342C1383860
DiseaseCardiomegaly

DMD ITPR2

4.04e-0382342C0018800
Diseaseplatelet crit

THOP1 PDE10A MFSD13A TNPO3 ITPR2

4.43e-03952345EFO_0007985

Protein segments in the cluster

PeptideGeneStartEntry
NRMIEQYHNHSDHYC

ASH1L

2186

Q9NR48
SHFQQTFCYLMHEFH

ELMOD1

271

Q8N336
EFVEHLISQMCHYQH

BTRC

151

Q9Y297
LISQMCHYQHGHINS

BTRC

156

Q9Y297
FQLHHQMHYSQQITV

DMD

266

P11532
DANVNVIYICSHHMN

IQCH

486

Q86VS3
HIFMNNYHLCNEISE

ITPR2

1276

Q14571
EHHFQQAHYDKCVIN

ACACB

1141

O00763
NNQVSFLHVYHHCTM

ELOVL4

151

Q9GZR5
VTVAHCMYAILQNNH

PDE10A

521

Q9Y233
YHNAVHAADVTQAMH

PDE7A

211

Q13946
ISRMCHYQHGHINSY

FBXW11

96

Q9UKB1
MHETSQYHVQHLATF

EPS8L2

46

Q9H6S3
ALATQYMHCVNHAKQ

CHCHD3

206

Q9NX63
VFCWMQHDQCHSHFQ

ELOVL6

216

Q9H5J4
QITFLHVYHHASMFN

ELOVL2

141

Q9NXB9
VFSCSVMHEALHNHY

IGHG2

301

P01859
MAYQICQSINFLHHN

CLK4

266

Q9HAZ1
HAQHSLMDGYCMFNH

HDAC6

216

Q9UBN7
SMDLVQVFHCHFNSN

MFSD13A

271

Q14CX5
NHSAFSMHALLVNHY

RETSAT

271

Q6NUM9
HIYHQHFDSVMQLQE

MOB1A

161

Q9H8S9
FHQVYNLTFHMHTHN

FEZF1

381

A0PJY2
YQHFSCNIRNIHHHQ

SRBD1

421

Q8N5C6
QVYHSQLNMSHQFSH

TASOR

1596

Q9UK61
AFINYSCLTVHHRMH

ZNF624

536

Q9P2J8
HCTRNYIHMHLFISF

VIPR1

171

P32241
YHNQCQEVLHHISMI

ELAC2

591

Q9BQ52
HCTRNYIHMHLFVSF

SCTR

171

P47872
HHDMTQPLNHYFINS

PLCB2

311

Q00722
TQMVNVYHVHQHSCF

TNPO3

686

Q9Y5L0
YFHEFGHVMHQLCSQ

THOP1

471

P52888
MHLTNYSVNKHNEHF

TTLL7

246

Q6ZT98
NYMLFREHSQTCHRH

USP17L10

106

C9JJH3
QLAAIHHNNCMYIAH

ZW10

536

O43264
HHNNCMYIAHHLLTL

ZW10

541

O43264