Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionSUMO transferase activity

RGPD4 RGPD8 MUL1 RGPD3

1.38e-0636464GO:0019789
GeneOntologyMolecularFunctionphosphatidylinositol-4,5-bisphosphate 4-phosphatase activity

PIP4P2 PIP4P1

5.19e-062462GO:0034597
GeneOntologyMolecularFunctionSUMO ligase activity

RGPD4 RGPD8 RGPD3

1.27e-0520463GO:0061665
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

RGPD4 RGPD8 RGPD3

2.08e-0450463GO:0003755
GeneOntologyMolecularFunctionphosphatidylinositol phosphate 4-phosphatase activity

PIP4P2 PIP4P1

2.31e-0410462GO:0034596
GeneOntologyMolecularFunctioncis-trans isomerase activity

RGPD4 RGPD8 RGPD3

2.47e-0453463GO:0016859
GeneOntologyMolecularFunctionphosphatidylinositol-4,5-bisphosphate phosphatase activity

PIP4P2 PIP4P1

3.38e-0412462GO:0106019
GeneOntologyMolecularFunctionGTPase activator activity

RGPD4 VAV3 RGPD8 RGPD3 RGPD5

4.41e-04279465GO:0005096
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

LRP6 STAB2

6.10e-0416462GO:0005041
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

LRP6 STAB2

1.06e-0321462GO:0030228
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

RGPD4 RGPD8 TTC3 RBBP6 MUL1 RGPD3

1.08e-03512466GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

RGPD4 RGPD8 TTC3 RBBP6 MUL1 RGPD3

1.32e-03532466GO:0016755
GeneOntologyMolecularFunctionphosphatidylinositol bisphosphate phosphatase activity

PIP4P2 PIP4P1

1.76e-0327462GO:0034593
GeneOntologyMolecularFunctionhyaluronic acid binding

STAB2 NCAN

2.03e-0329462GO:0005540
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

RGPD4 RGPD8 RBBP6 MUL1 RGPD3

2.15e-03398465GO:0061659
GeneOntologyMolecularFunctionphosphatidylinositol phosphate phosphatase activity

PIP4P2 PIP4P1

2.17e-0330462GO:0052866
GeneOntologyBiologicalProcessNLS-bearing protein import into nucleus

RGPD4 RGPD8 RGPD3 RGPD5

1.12e-0720474GO:0006607
GeneOntologyBiologicalProcesspositive regulation of glucokinase activity

RGPD4 RGPD8 RGPD3

9.23e-079473GO:0033133
GeneOntologyBiologicalProcesspositive regulation of hexokinase activity

RGPD4 RGPD8 RGPD3

1.32e-0610473GO:1903301
GeneOntologyBiologicalProcessregulation of glucokinase activity

RGPD4 RGPD8 RGPD3

3.12e-0613473GO:0033131
GeneOntologyBiologicalProcessregulation of hexokinase activity

RGPD4 RGPD8 RGPD3

3.97e-0614473GO:1903299
GeneOntologyBiologicalProcesscell recognition

EPHB3 C4BPA ADAM32 ZAN PEAR1

8.57e-05198475GO:0008037
GeneOntologyBiologicalProcessprotein peptidyl-prolyl isomerization

RGPD4 RGPD8 RGPD3

8.85e-0538473GO:0000413
GeneOntologyBiologicalProcessbinding of sperm to zona pellucida

C4BPA ADAM32 ZAN

2.27e-0452473GO:0007339
GeneOntologyBiologicalProcesspeptidyl-proline modification

RGPD4 RGPD8 RGPD3

2.54e-0454473GO:0018208
GeneOntologyCellularComponentcytoplasmic periphery of the nuclear pore complex

RGPD4 RGPD8 RGPD3

5.92e-078473GO:1990723
GeneOntologyCellularComponentnuclear pore cytoplasmic filaments

RGPD4 RGPD8 RGPD3

1.26e-0610473GO:0044614
GeneOntologyCellularComponentannulate lamellae

RGPD4 RGPD8 RGPD3

3.81e-0614473GO:0005642
GeneOntologyCellularComponentnuclear pore nuclear basket

RGPD4 RGPD8 RGPD3

8.49e-0618473GO:0044615
GeneOntologyCellularComponentnuclear inclusion body

RGPD4 RGPD8 RGPD3

1.18e-0520473GO:0042405
GeneOntologyCellularComponentSUMO ligase complex

RGPD4 RGPD8 RGPD3

1.38e-0521473GO:0106068
GeneOntologyCellularComponentnuclear pore

RGPD4 RGPD8 RGPD3 RGPD5

7.81e-05101474GO:0005643
GeneOntologyCellularComponentinclusion body

RGPD4 RGPD8 RGPD3

1.09e-0390473GO:0016234
MousePhenoelevated level of mitotic sister chromatid exchange

RGPD4 RGPD8 RGPD3

1.18e-0516403MP:0003701
MousePhenodecreased parotid gland size

UNK CRIM1

2.39e-053402MP:0009532
MousePhenoabnormal morula morphology

RGPD4 RGPD8 RGPD3

5.39e-0526403MP:0012058
MousePhenodecreased tumor latency

RGPD4 RGPD8 RGPD3

8.35e-0530403MP:0010308
MousePhenofailure of blastocyst formation

RGPD4 RGPD8 RGPD3

9.23e-0531403MP:0012129
MousePhenoabnormal tumor latency

RGPD4 RGPD8 RGPD3

1.22e-0434403MP:0010307
MousePhenoabnormal blastocyst formation

RGPD4 RGPD8 RGPD3

1.85e-0439403MP:0012128
MousePhenoabnormal parotid gland morphology

UNK CRIM1

2.84e-049402MP:0003452
DomainGrip

RGPD4 RGPD8 RGPD3 RGPD5

9.58e-0911454SM00755
DomainGRIP

RGPD4 RGPD8 RGPD3 RGPD5

9.58e-0911454PF01465
DomainRan_BP1

RGPD4 RGPD8 RGPD3 RGPD5

1.43e-0812454PF00638
DomainGRIP_dom

RGPD4 RGPD8 RGPD3 RGPD5

1.43e-0812454IPR000237
DomainGRIP

RGPD4 RGPD8 RGPD3 RGPD5

1.43e-0812454PS50913
DomainRANBD1

RGPD4 RGPD8 RGPD3 RGPD5

1.43e-0812454PS50196
DomainRanBD

RGPD4 RGPD8 RGPD3 RGPD5

2.07e-0813454SM00160
DomainRan_bind_dom

RGPD4 RGPD8 RGPD3 RGPD5

2.07e-0813454IPR000156
DomainEGF_3

LRP6 EYS STAB2 ADAM32 ZAN VWDE NCAN PEAR1

8.05e-08235458PS50026
DomainEGF

LRP6 EYS STAB2 ADAM32 ZAN VWDE NCAN PEAR1

8.05e-08235458SM00181
DomainEGF-like_dom

LRP6 EYS STAB2 ADAM32 ZAN VWDE NCAN PEAR1

1.26e-07249458IPR000742
DomainEGF_1

LRP6 EYS STAB2 ADAM32 ZAN VWDE NCAN PEAR1

1.51e-07255458PS00022
DomainEGF-like_CS

LRP6 EYS STAB2 ADAM32 ZAN VWDE NCAN PEAR1

1.80e-07261458IPR013032
DomainEGF_2

LRP6 EYS STAB2 ADAM32 ZAN VWDE NCAN PEAR1

2.02e-07265458PS01186
DomainGCC2_Rab_bind

RGPD4 RGPD8 RGPD3

4.54e-077453IPR032023
DomainRab_bind

RGPD4 RGPD8 RGPD3

4.54e-077453PF16704
Domain-

RGPD4 RGPD8 RGPD3

1.55e-06104531.10.220.60
DomainTmemb_55A

PIP4P2 PIP4P1

5.68e-062452PF09788
DomainPtdIns-P2-Ptase

PIP4P2 PIP4P1

5.68e-062452IPR019178
DomainEGF

LRP6 EYS STAB2 ZAN NCAN

1.27e-05126455PF00008
DomainTPR-contain_dom

RGPD4 RGPD8 TTC3 RGPD3 RGPD5

2.95e-05150455IPR013026
DomainTPR_REGION

RGPD4 RGPD8 TTC3 RGPD3 RGPD5

4.65e-05165455PS50293
DomainTPR

RGPD4 RGPD8 TTC3 RGPD3 RGPD5

4.65e-05165455PS50005
DomainTPR-like_helical_dom

RGPD4 RGPD8 TTC3 RGPD3 RGPD5

2.35e-04233455IPR011990
DomainTPR

RGPD4 RGPD8 TTC3 RGPD3

2.60e-04129454SM00028
DomainSushi

C4BPA SEZ6L2 NCAN

2.66e-0452453PF00084
DomainTPR_repeat

RGPD4 RGPD8 TTC3 RGPD3

2.92e-04133454IPR019734
DomainCCP

C4BPA SEZ6L2 NCAN

2.97e-0454453SM00032
DomainSUSHI

C4BPA SEZ6L2 NCAN

3.31e-0456453PS50923
DomainSushi_SCR_CCP_dom

C4BPA SEZ6L2 NCAN

3.49e-0457453IPR000436
DomainLINK

STAB2 NCAN

4.35e-0413452SM00445
DomainLink_dom

STAB2 NCAN

4.35e-0413452IPR000538
DomainXlink

STAB2 NCAN

4.35e-0413452PF00193
DomainLINK_1

STAB2 NCAN

4.35e-0413452PS01241
DomainLINK_2

STAB2 NCAN

4.35e-0413452PS50963
DomainGrowth_fac_rcpt_

EPHB3 EYS STAB2 CRIM1

5.35e-04156454IPR009030
DomainZnf_C2H2-like

HIVEP3 ZNF750 ZNF205 ZNF668 ZNF764 ZNF689 ZNF441 ZNF513

5.58e-04796458IPR015880
DomainZnf_C2H2

HIVEP3 ZNF750 ZNF205 ZNF668 ZNF764 ZNF689 ZNF441 ZNF513

6.01e-04805458IPR007087
DomainZnF_C2H2

HIVEP3 ZNF750 ZNF205 ZNF668 ZNF764 ZNF689 ZNF441 ZNF513

6.16e-04808458SM00355
DomainVWD

ZAN VWDE

6.67e-0416452SM00216
DomainVWF_type-D

ZAN VWDE

6.67e-0416452IPR001846
DomainVWFD

ZAN VWDE

6.67e-0416452PS51233
DomainVWD

ZAN VWDE

6.67e-0416452PF00094
DomainVWC_out

ZAN CRIM1

9.46e-0419452SM00215
Domain-

HIVEP3 ZNF205 ZNF668 ZNF764 ZNF689 ZNF441 ZNF513

1.11e-036794573.30.160.60
Domainzf-C2H2

HIVEP3 ZNF205 ZNF668 ZNF764 ZNF689 ZNF441 ZNF513

1.25e-03693457PF00096
DomainZnf_C2H2/integrase_DNA-bd

HIVEP3 ZNF205 ZNF668 ZNF764 ZNF689 ZNF441 ZNF513

1.26e-03694457IPR013087
DomainTPR_1

RGPD8 TTC3 RGPD5

1.33e-0390453PF00515
DomainTPR_1

RGPD8 TTC3 RGPD5

1.33e-0390453IPR001440
Domainzf-CCHC

LIN28B RBBP6

1.39e-0323452PF00098
Domain-

RGPD4 RGPD8 TTC3 RGPD3

1.53e-032074541.25.40.10
Domain-

LIN28B RBBP6

1.78e-03264524.10.60.10
DomainZINC_FINGER_C2H2_2

HIVEP3 ZNF205 ZNF668 ZNF764 ZNF689 ZNF441 ZNF513

2.36e-03775457PS50157
DomainZINC_FINGER_C2H2_1

HIVEP3 ZNF205 ZNF668 ZNF764 ZNF689 ZNF441 ZNF513

2.40e-03777457PS00028
DomainEGF_CA

EYS STAB2 NCAN

3.16e-03122453SM00179
DomainZF_CCHC

LIN28B RBBP6

3.21e-0335452PS50158
DomainEGF_Lam

STAB2 PEAR1

3.21e-0335452SM00180
DomainEGF-like_Ca-bd_dom

EYS STAB2 NCAN

3.31e-03124453IPR001881
DomainVWFC_1

ZAN CRIM1

3.39e-0336452PS01208
DomainPH_dom-like

RGPD4 VAV3 RGPD8 RGPD3 RGPD5

3.48e-03426455IPR011993
DomainVWC

ZAN CRIM1

3.78e-0338452SM00214
DomainVWFC_2

ZAN CRIM1

3.78e-0338452PS50184
DomainLaminin_EGF

STAB2 PEAR1

3.78e-0338452IPR002049
DomainLDLR_class-A_CS

LRP6 CFI

4.18e-0340452IPR023415
Domain-

UNK UNKL

4.18e-03404524.10.1000.10
Domain-

TTC3 JADE3 KDM5A RBBP6 MUL1

4.35e-034494553.30.40.10
DomainVWF_dom

ZAN CRIM1

4.60e-0342452IPR001007
DomainZnf_RING/FYVE/PHD

TTC3 JADE3 KDM5A RBBP6 MUL1

4.77e-03459455IPR013083
DomainZF_RING_1

UNKL TTC3 RBBP6 MUL1

5.21e-03291454PS00518
DomainLdl_recept_a

LRP6 CFI

5.26e-0345452PF00057
Domain-

LRP6 CFI

5.49e-03464524.10.400.10
DomainZF_RING_2

UNKL TTC3 RBBP6 MUL1

5.66e-03298454PS50089
DomainZnF_C3H1

UNK UNKL

5.97e-0348452SM00356
DomainLDLRA_1

LRP6 CFI

5.97e-0348452PS01209
DomainRING

UNKL TTC3 RBBP6 MUL1

6.14e-03305454SM00184
Domainzf-CCCH

UNK UNKL

6.21e-0349452PF00642
DomainLDLRA_2

LRP6 CFI

6.21e-0349452PS50068
DomainLDrepeatLR_classA_rpt

LRP6 CFI

6.21e-0349452IPR002172
DomainLDLa

LRP6 CFI

6.21e-0349452SM00192
PathwayBIOCARTA_RANBP2_PATHWAY

RGPD4 RGPD8 RGPD3

1.12e-0518353MM1549
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

RGPD4 RGPD8 RGPD3

1.30e-0440353MM14945
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

RGPD4 RGPD8 RGPD3

1.40e-0441353MM15200
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

RGPD4 RGPD8 RGPD3

1.51e-0442353MM15039
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

RGPD4 RGPD8 RGPD3

1.62e-0443353MM14609
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

RGPD4 RGPD8 RGPD3

2.11e-0447353MM14939
PathwayREACTOME_GENE_SILENCING_BY_RNA

RGPD4 RGPD8 RGPD3

2.39e-0449353MM14837
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

RGPD4 RGPD8 RGPD3

2.54e-0450353MM14610
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

RGPD4 RGPD8 RGPD3

2.69e-0451353MM15151
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

RGPD4 RGPD8 RGPD3

3.37e-0455353MM14917
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

RGPD4 RGPD8 RGPD3

3.94e-0458353MM15149
PathwayREACTOME_SNRNP_ASSEMBLY

RGPD4 RGPD8 RGPD3

3.94e-0458353MM14736
PathwayREACTOME_METABOLISM_OF_CARBOHYDRATES

RGPD4 STAB2 RGPD8 HS6ST1 RGPD3

5.12e-04271355MM15406
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

RGPD4 RGPD8 RGPD3

5.51e-0465353MM15147
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

RGPD4 ZNF750 ZNF205 RGPD8 CDK12 ZNF764 ZNF689 RGPD3 PIP4P1

6.74e-041022359MM15436
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

RGPD4 RGPD8 RGPD3

7.74e-0473353MM14948
PathwayREACTOME_GLUCOSE_METABOLISM

RGPD4 RGPD8 RGPD3

1.09e-0382353MM15394
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

RGPD4 RGPD8 RGPD3

1.16e-0384353MM14929
PathwayREACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

RGPD4 RGPD8 RGPD3

1.25e-0386353MM15413
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

RGPD4 RGPD8 RGPD3

1.51e-0392353MM14951
PathwayREACTOME_AMPLIFICATION_OF_SIGNAL_FROM_THE_KINETOCHORES

RGPD4 RGPD8 RGPD3

1.92e-03100353MM14561
PathwayREACTOME_MITOTIC_PROPHASE

RGPD4 RGPD8 RGPD3

2.79e-03114353MM15361
PathwayREACTOME_MITOTIC_SPINDLE_CHECKPOINT

RGPD4 RGPD8 RGPD3

3.01e-03117353MM15387
PathwayREACTOME_EPH_EPHRIN_MEDIATED_REPULSION_OF_CELLS

EPHB3 VAV3

3.20e-0334352MM15025
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD4 RGPD8 RGPD3 RGPD5

1.02e-10747415710750
Pubmed

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

RGPD4 RGPD8 RGPD3

8.06e-08747330944974
Pubmed

Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.

RGPD4 RGPD8 RGPD3

8.06e-08747338838144
Pubmed

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.

RGPD4 RGPD8 RGPD3

8.06e-08747321205196
Pubmed

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.

RGPD4 RGPD8 RGPD3

8.06e-08747318949001
Pubmed

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

RGPD4 RGPD8 RGPD3

8.06e-08747325187515
Pubmed

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

RGPD4 RGPD8 RGPD3

8.06e-0874739037092
Pubmed

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

RGPD4 RGPD8 RGPD3

8.06e-08747323536549
Pubmed

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

RGPD4 RGPD8 RGPD3

8.06e-0874738603673
Pubmed

Retina-specifically expressed novel subtypes of bovine cyclophilin.

RGPD4 RGPD8 RGPD3

8.06e-0874737559465
Pubmed

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

RGPD4 RGPD8 RGPD3

8.06e-08747326632511
Pubmed

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

RGPD4 RGPD8 RGPD3

8.06e-08747317372272
Pubmed

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

RGPD4 RGPD8 RGPD3

8.06e-08747324403063
Pubmed

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

RGPD4 RGPD8 RGPD3

8.06e-08747323818861
Pubmed

Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.

RGPD4 RGPD8 RGPD3

8.06e-08747338657106
Pubmed

Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

RGPD4 RGPD8 RGPD3

8.06e-08747311353387
Pubmed

Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.

RGPD4 RGPD8 RGPD3

8.06e-08747312191015
Pubmed

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

RGPD4 RGPD8 RGPD3

8.06e-08747322821000
Pubmed

Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.

RGPD4 RGPD8 RGPD3

8.06e-08747320682751
Pubmed

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.

RGPD4 RGPD8 RGPD3

1.29e-07847322262462
Pubmed

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.

RGPD4 RGPD8 RGPD3

1.29e-07847321670213
Pubmed

Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.

RGPD4 RGPD8 RGPD3

1.29e-07847328745977
Pubmed

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

RGPD4 RGPD8 RGPD3

1.29e-07847327412403
Pubmed

Mice lacking Ran binding protein 1 are viable and show male infertility.

RGPD4 RGPD8 RGPD3

1.29e-07847321310149
Pubmed

The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.

RGPD4 RGPD8 RGPD3

1.93e-0794739733766
Pubmed

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.

RGPD4 RGPD8 RGPD3

1.93e-07947328100513
Pubmed

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.

RGPD4 RGPD8 RGPD3

1.93e-07947318394993
Pubmed

Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.

RGPD4 RGPD8 RGPD3

1.93e-07947328877029
Pubmed

The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.

RGPD4 RGPD8 RGPD3

1.93e-07947311553612
Pubmed

Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.

RGPD4 RGPD8 RGPD3

1.93e-07947317887960
Pubmed

The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.

RGPD4 RGPD8 RGPD3

1.93e-07947310601307
Pubmed

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.

RGPD4 RGPD8 RGPD3

2.76e-071047327160050
Pubmed

Parkin ubiquitinates and promotes the degradation of RanBP2.

RGPD4 RGPD8 RGPD3

2.76e-071047316332688
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

RGPD4 RGPD8 RGPD3

2.76e-07104738857542
Pubmed

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

RGPD4 RGPD8 RGPD3

2.76e-071047321859863
Pubmed

An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.

RGPD4 RGPD8 RGPD3

3.79e-071147335771867
Pubmed

RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

RGPD4 RGPD8 RGPD3

3.79e-071147317069463
Pubmed

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.

RGPD4 RGPD8 RGPD3

3.79e-071147334110283
Pubmed

Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.

RGPD4 RGPD8 RGPD3

6.55e-071347331427429
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

RGPD4 RGPD8 RGPD3

1.04e-061547314697343
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

HIVEP3 ZNF750 UNK ZNF205 ZNF668 KDM5A ZNF764 ZNF689 ZNF513

1.17e-0680847920412781
Pubmed

The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases.

PIP4P2 PIP4P1

1.79e-06247216365287
Pubmed

The embryonically active gene, unkempt, of Drosophila encodes a Cys3His finger protein.

UNK UNKL

1.79e-0624721339381
Pubmed

Non-small cell lung cancer cells produce a functional set of complement factor I and its soluble cofactors.

C4BPA CFI

1.79e-06247217548110
Pubmed

TMEM55a localizes to macrophage phagosomes to downregulate phagocytosis.

PIP4P2 PIP4P1

1.79e-06247229378918
Pubmed

Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.

RGPD4 RGPD8 RGPD3

3.50e-062247327717094
Pubmed

A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways.

VAV3 PEAR1

5.36e-06347219429868
Pubmed

Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.

RGPD8 RGPD5

1.07e-0544729480752
Pubmed

Peering through the pore: nuclear pore complex structure, assembly, and function.

RGPD4 RGPD8 RGPD3

1.89e-053847312791264
Pubmed

Epidemiological approach to identifying genetic predispositions for atypical hemolytic uremic syndrome.

C4BPA CFI

6.40e-05947220059470
Pubmed

Genome-wide association study of anthropometric traits in Korcula Island, Croatia.

CRIM1 SEZ6L2

6.40e-05947219260139
Pubmed

Defining brain wiring patterns and mechanisms through gene trapping in mice.

CRIM1 HS6ST1

1.61e-041447211242070
Pubmed

The zinc finger/RING domain protein Unkempt regulates cognitive flexibility.

UNK UNKL

1.86e-041547234381067
Pubmed

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

RGPD4 RGPD8 RGPD3 RGPD5

2.06e-0421547435973513
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

RGPD4 RGPD8 RGPD3

2.19e-048647337253089
Pubmed

Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.

RGPD4 RGPD8 RBBP6 RGPD3

2.49e-0422647437839992
Pubmed

The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis.

LRP6 SPRY1

2.70e-041847234407391
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

RGPD4 ZNFX1 RGPD8 TTC3 KDM5A NCAN RGPD3

2.92e-0496347728671696
Pubmed

Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis.

RGPD4 RGPD8 RGPD3

3.31e-049947327746211
Pubmed

Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.

SEZ6L2 VWDE

6.61e-042847223006423
Pubmed

Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.

SPRY1 CRIM1

7.09e-042947220615956
Pubmed

Functional analysis of secreted and transmembrane proteins critical to mouse development.

LRP6 HS6ST1

8.11e-043147211431694
Pubmed

Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7).

RBBP6 SMYD3

8.11e-043147226678539
Pubmed

Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.

RGPD4 RGPD8 RGPD3

8.18e-0413547331077711
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

RGPD4 RGPD8 RGPD3

1.03e-0314647323892456
Pubmed

Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.

EPHB3 TTC3

1.16e-033747226951610
Pubmed

Systematic identification of factors for provirus silencing in embryonic stem cells.

RGPD4 RGPD8 RGPD3

1.17e-0315347326365490
InteractionRGPD4 interactions

RGPD4 RGPD8 RGPD3 RGPD5

1.84e-0722474int:RGPD4
InteractionRGPD2 interactions

RGPD4 RGPD8 RGPD3 RGPD5

4.38e-0727474int:RGPD2
InteractionRGPD3 interactions

RGPD4 RGPD8 RGPD3 RGPD5

4.30e-0647474int:RGPD3
InteractionRGPD1 interactions

RGPD4 RGPD8 RGPD3 RGPD5

5.09e-0649474int:RGPD1
InteractionRGPD8 interactions

RGPD4 RGPD8 RGPD3 RGPD5

2.65e-0574474int:RGPD8
InteractionRGPD5 interactions

RGPD4 RGPD8 RGPD3 RGPD5

7.37e-0596474int:RGPD5
Cytoband16p11.2

ZNF668 SEZ6L2 ZNF764 ZNF689

4.50e-0519147416p11.2
Cytoband2q13

RGPD8 RGPD3 RGPD5

4.81e-05684732q13
CytobandEnsembl 112 genes in cytogenetic band chr16p11

ZNF668 SEZ6L2 ZNF764 ZNF689

1.91e-04278474chr16p11
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

RGPD4 RGPD8 TTC3 RGPD3 RGPD5

2.66e-06115355769
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

C4BPA SEZ6L2 NCAN

1.81e-04573531179
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

HIVEP3 ZNF205 ZNF668 ZNF764 ZNF689 ZNF441 ZNF513

3.85e-0471835728
GeneFamilyPhosphoinositide phosphatases

PIP4P2 PIP4P1

1.74e-03323521079
GeneFamilyZinc fingers CCCH-type

UNK UNKL

2.08e-033535273
CoexpressionNAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_CORRELATED_WITH_HAI_28DY_RESPONSE_AT_7DY_NEGATIVE

RGPD4 UNK RGPD8 RBBP6 TESPA1 RGPD3 PIP4P1 RGPD5

1.83e-06474478M40991
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_B_UP

RGPD4 RGPD8 RGPD3

2.84e-0533473MM477
ToppCelldroplet-Liver-nan-3m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF205 VAV3 STAB2 CRIM1 PEAR1

1.33e-06181475fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCellwk_20-22-Hematologic-Myeloid-HSC|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ZAN LIN28B VWDE TESPA1

2.69e-05164474a35a0725b8bfe3cad5b85484217fd8a02bdee827
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF205 ARL15 ZNF689 PEAR1

2.75e-0516547462457b7b74c6eae42d91d65e7dc6df6bf8e061f7
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

LRP6 CFI SEZ6L2 ZNF764

2.82e-0516647489e2b8453180983533faccb4275867861876d7ee
ToppCellControl-Neuronal_cells|Control / group, cell type (main and fine annotations)

SPRY1 VAV3 STAB2 PEAR1

3.54e-05176474c29d09ecf0eb17f767d78af4b7f2e7725c967ff8
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VAV3 LIN28B OTOGL TESPA1

3.54e-0517647440993c41c1017b53039a337174fc56632b278609
ToppCellControl-Neuronal_cells-Neuronal_cells|Control / group, cell type (main and fine annotations)

SPRY1 VAV3 STAB2 PEAR1

3.54e-0517647498c07d26ba0dc0fe15ca0ea81f633d4591782bd1
ToppCellwk_20-22-Epithelial-Proximal_epithelial-basal_late|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ZNF750 ADAM32 VWDE RGPD3

3.70e-0517847403f22485074b3cbf9a6ad4d543c5bbfa826dc741
ToppCell5'-Airway_Nasal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VAV3 VWDE TESPA1 SMYD3

4.03e-051824744cd5eb13f78f4f377932c50ac2acb4ac0cd14c12
ToppCellASK440-Immune-Mast_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

ZNF750 TESPA1 SMYD3 HS6ST1

4.67e-0518947472a19b20cb0f7283afe5f85d62a21cff69fd78d0
ToppCellParenchymal-10x5prime-Epithelial-Epi_alveolar-Dividing_AT2|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ZNF750 EYS C4BPA VWDE

5.07e-0519347444839a606ae2f8e37421bda46d588189e1c943d2
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP6 C4BPA CFI SEZ6L2

5.71e-051994742dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2|Control_saline / Treatment groups by lineage, cell group, cell type

LRP6 SPRY1 CRIM1 OTOGL

5.82e-05200474bc8949eb34482aca166c4602ff6ab876cb4c2c3c
ToppCelldroplet-Liver-Hepatocytes-24m-Epithelial-Hepatocyte_(Midlobular)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAM32 CFI MUL1

1.76e-041034733a0f02ce52c4e2eda5b987c89317280c08f90cb3
ToppCellTCGA-Testes|World / Sample_Type by Project: Shred V9

GJA10 ZAN LIN28B

3.33e-04128473a09b0e221b8749510002304e4d34d6a2eb8867e9
ToppCellpdx-Tumor_cells-T9|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

SPRY1 ZNFX1 CRIM1

4.70e-041444730b94d978262a826c9254145aa98c6c30240243f9
ToppCellFetal_29-31_weeks-Immune-mast_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

VAV3 LIN28B VWDE

4.79e-04145473dc89d817a9bef24a07e992efdab4136f12ceb399
ToppCellChildren_(3_yrs)-Immune-mast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

TESPA1 SMYD3 HS6ST1

6.04e-04157473ec185dbeabb67fd9ca85f71cab88463b60f9b1c1
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_neural-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SEZ6L2 JADE3 NCAN

6.50e-04161473bd520c9a1927d5d5355b4421e6b90b58bfb76a42
ToppCell367C-Lymphocytic-ILC-ILC-3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

SPRY1 C4BPA CDK12

6.50e-041614738de421c61f4d5a6e05fdb20e4d230e2db98ee4d5
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZAN LIN28B OTOGL

6.61e-04162473bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

LRP6 CFI SEZ6L2

6.61e-041624732259e9536147e9cdee772e3a30ba7d104573262c
ToppCellFetal_29-31_weeks-Immune-mast_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

VAV3 LIN28B TESPA1

6.73e-0416347303b2ec226adffba3ce893f3d12e549c841e662fd
ToppCell356C-Myeloid-Mast_cell|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

TESPA1 SMYD3 HS6ST1

6.85e-04164473b3192c443f4848e6a8afdb89c155f9ec42a154b0
ToppCell356C-Myeloid-Mast_cell-|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

TESPA1 SMYD3 HS6ST1

6.85e-04164473f7288ec4daf494dae770ea6c58bead27660ccae1
ToppCellsevere-unassigned|World / disease stage, cell group and cell class

ZNF668 HS6ST1 ZNF513

6.85e-04164473b3a45c150df6594debeeca400cc58d30ef662756
ToppCellMild-Myeloid-Mast-|Mild / Condition, Lineage, Cell class and cell subclass

EYS TESPA1 HS6ST1

6.98e-0416547393d3909a0f5f43d473d5005c842d7d73e25eceed
ToppCellnucseq-Immune-Hematopoietic-Granulocytic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TESPA1 SMYD3 HS6ST1

6.98e-0416547337615622c736e43260c38016e7c9e565ac97a3e8
ToppCellsevere-unassigned|severe / disease stage, cell group and cell class

ZNF668 HS6ST1 ZNF513

6.98e-04165473f9ddd547992fec065d539a1d0305acba8fc7d79c
ToppCellMild-Myeloid-Mast|Mild / Condition, Lineage, Cell class and cell subclass

EYS TESPA1 HS6ST1

6.98e-041654735fa9552c37890c5cc7e672a47038aebba2413cb4
ToppCellnucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TESPA1 SMYD3 HS6ST1

6.98e-04165473640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCellnucseq-Immune-Hematopoietic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TESPA1 SMYD3 HS6ST1

6.98e-04165473f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCellfacs-Aorta-Heart-3m-Endothelial-endocardial_endothelial_cells|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 OTOGL PEAR1

7.22e-04167473a4a795751644b22af616335379e64ae95175180c
ToppCellsevere-CD4+_T_naive|severe / disease stage, cell group and cell class

LRP6 TESPA1 ZNF764

7.22e-0416747302a8215fca59c357c1cdaa5738849eacf98c0bcc
ToppCellCOVID-19_Mild-PLT_2|World / Disease Group and Platelet Clusters

TLR7 RGPD8 RGPD3

7.48e-041694736abfdc8b437f19c03b408bedc245059d28c6ba6a
ToppCellControl-Mast_cells|Control / group, cell type (main and fine annotations)

VAV3 TESPA1 HS6ST1

7.48e-04169473fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VAV3 OTOGL TESPA1

7.48e-04169473319cba07263bf41fcbcbfecd117f91b729394241
ToppCellControl-Mast_cells-Mast_cells|Control / group, cell type (main and fine annotations)

VAV3 TESPA1 HS6ST1

7.61e-04170473c80f6d29096c372da95a8407f402349ff1bb7018
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-Regulatory_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWDE TESPA1 PEAR1

7.87e-041724733acf35b774ebc0f9e96299d0bd3e9d03bbf6b90c
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EYS TESPA1 SMYD3

7.87e-041724733a37569a5902f3c65ff8d3912421309a8c82ee9b
ToppCellfacs-Heart-LV-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRIM1 CFI OTOGL

7.87e-04172473f2c17c49b375b28ad47dc6cabda62f1c238023dd
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EYS TESPA1 SMYD3

7.87e-04172473cc9d9dae290f11f8c348c78228af4e49469dc93b
ToppCellfacs-Heart-LV-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRIM1 CFI OTOGL

7.87e-041724736ab4f01098dddb789df298ddf97b3c384405ee6c
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-regulatory_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWDE TESPA1 PEAR1

7.87e-041724734d04df9776394ea156ed5822f92ae74fdefbaa3d
ToppCellImmune-mast_cell|World / Lineage, Cell type, age group and donor

LIN28B TESPA1 HS6ST1

7.87e-041724736e8e0aac5a20dbc789bf8c6916833bb8709a411a
ToppCell3'-Pediatric_IBD-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF750 STAB2 PEAR1

7.87e-041724731bad7b19724e1b53ace7e05644215334c9f43910
ToppCellAdult-Mesenchymal-pericyte_cell-D231|Adult / Lineage, Cell type, age group and donor

SPRY1 CRIM1 PEAR1

7.87e-04172473858cee96c1c06160863b4adcd7023c0d678bd50f
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-B_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNFX1 HS6ST1 NCAN

8.00e-041734730a0cd40bb5f61431fe34758626c8a63ec610a8a5
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D122|Adult / Lineage, Cell type, age group and donor

VAV3 CRIM1 PEAR1

8.00e-04173473dba09ba9748871e38a16449d500ae4d7b405c42f
ToppCellwk_15-18-Hematologic-Myeloid-Eosinophil|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ZAN LIN28B TESPA1

8.00e-04173473a85cead231e03945fabbc7762540ad21fe4299df
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARL15 LIN28B OTOGL

8.13e-04174473ae363ce736fc8af439f3ad594d7bc2e344db80d4
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-regulatory_T_cell-regulatory_T_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWDE TESPA1 PEAR1

8.27e-041754733bdccb4037053795d62ab5b6fcc09cdd406f9b50
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-regulatory_T_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWDE TESPA1 PEAR1

8.27e-04175473770546ddaa49ee482c4c7577ab76efbc6c304a29
ToppCellASK452-Endothelial-Lymphatic|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

SPRY1 STAB2 PEAR1

8.41e-04176473b4d280ecc07701d526f50d44c45ea91b3eeb00b1
ToppCellmetastatic_Brain-Endothelial_cells-Lymphatic_ECs|Endothelial_cells / Location, Cell class and cell subclass

VAV3 STAB2 SEZ6L2

8.41e-0417647342541dfe20eb29625d47c0bb79bf3c21a2460340
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

STAB2 SEZ6L2 MUL1

8.41e-04176473a9e77681bcd36c382d53eb6f771349d55f98d744
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-Mast_cell|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RGPD8 TESPA1 SMYD3

8.41e-0417647301ae63366f0a25f46d3c8a3596e0dffdeba54a58
ToppCellASK428-Epithelial-Secretory|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

VAV3 TLR7 TESPA1

8.55e-0417747366074a288501c136b4e83b883db5f0d8269ee326
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3-4_RORB_FOLH1B|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VAV3 LIN28B TESPA1

8.69e-0417847322955b82917206aeed49dc0ac4630ccd9e51c4a5
ToppCell(5)_Glands_mucous|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

C4BPA SEZ6L2 KDM5A

8.69e-04178473f0f19b0d78f2cc5df4d4c321a953a6e447d5114a
ToppCellB_cells-Naive_B_cells_|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

HIVEP3 SPRY1 VAV3

8.69e-0417847371ac2eca5cf13a91f86b80690748b0788392dcfc
ToppCelldroplet-Marrow-nan-3m-Hematologic-hematopoietic_precursor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRIM1 TTC3 TESPA1

8.69e-041784738aef208b6351143562c87715bb11628880abce94
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VAV3 LIN28B TESPA1

8.69e-04178473674ee5095b98929c29e4f6bd56029a336cc4a38c
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIVEP3 TLR7 TTC3

8.83e-0417947387a69f9f83b8f0c028a4874acb238f2e079bf51f
ToppCelldroplet-Marrow-nan-3m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIVEP3 TLR7 TTC3

8.83e-04179473dcaf2191134a586d50ebaf67dcf5b815b54a722b
ToppCellSomatosensory_Cortex_(S1)|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VAV3 TESPA1 HS6ST1

8.83e-0417947382348bf56a4525b2f485696cab5b2ea6e96c2f91
ToppCellBAL-Mild-cDC_4|Mild / Compartment, Disease Groups and Clusters

UNKL ARL15 HS6ST1

8.83e-0417947368511e87b12b8253de7771e5ccfc5869248b8450
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VAV3 LIN28B TESPA1

8.97e-04180473fd8c2059fcb382ffbfe19e598e37a49e1d5637b5
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VAV3 LIN28B TESPA1

8.97e-041804735391d23817f5cc88a0871ddb98968897c839f464
ToppCelldroplet-Marrow-BM-1m-Hematologic-hematopoietic_precursor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC3 TESPA1 PEAR1

8.97e-04180473ff34195bb7325e61fbf823c103c5e6115d8f1248
ToppCell3'-Distal_airway-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TESPA1 SMYD3 HS6ST1

8.97e-041804738bd9e12589bff64987bac30af4d2514ba6f09300
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CRIM1 OTOGL PEAR1

9.12e-04181473451b87ac95154bb80018b8dd245b4a6389d81411
ToppCell367C-Myeloid-Mast_cell|367C / Donor, Lineage, Cell class and subclass (all cells)

TESPA1 SMYD3 HS6ST1

9.12e-04181473063fc83870f55f63c013f0276c1ec8f3abcbcf27
ToppCell367C-Myeloid-Mast_cell-|367C / Donor, Lineage, Cell class and subclass (all cells)

TESPA1 SMYD3 HS6ST1

9.12e-04181473e1161c9828ee94518eb5bef0b6228d71299c2f59
ToppCelldroplet-Marrow-nan-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRIM1 TTC3 TESPA1

9.26e-041824731710eab3037a87609d21838be2d2d29c3bc36651
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HIVEP3 STAB2 PEAR1

9.26e-0418247341b070085edba7a58b81c20aa4942d06f745acf8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HIVEP3 STAB2 PEAR1

9.26e-041824735e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HIVEP3 STAB2 PEAR1

9.26e-04182473b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SPRY1 STAB2 PEAR1

9.26e-0418247353c267ee327e116dbd89d5927ed3bdf78d25ee62
ToppCelldroplet-Marrow-nan-3m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRIM1 TTC3 TESPA1

9.26e-04182473e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCelldroplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 CRIM1 PEAR1

9.41e-04183473709a486154b3157427deb3b8886b63ac39ea42dd
ToppCelldroplet-Liver-nan-3m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 CRIM1 PEAR1

9.41e-04183473dc06f19f6f80f4c7f13f1f990c1fe0f91ba64ea7
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SPRY1 STAB2 PEAR1

9.41e-041834734d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCelldroplet-Thymus-nan-3m-Lymphocytic-Double_negative_Thymocyte,_DN4_(Cd8-,_Cd4-),_some_undergoing_VDJ_recombination_|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIVEP3 TTC3 TESPA1

9.41e-04183473a0a3e4d07ac73dbbb1e019fd11e88ccffe6cf2ca
ToppCellCalu_3-infected|Calu_3 / Cell line, Condition and Strain

ZNFX1 RBBP6 CDK12

9.41e-041834738f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 ZAN OTOGL

9.56e-04184473ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 ZAN OTOGL

9.56e-041844732cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 ZAN OTOGL

9.56e-041844732b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell15-Distal-Immune-Hematopoietic,_B_Cells|Distal / Age, Tissue, Lineage and Cell class

VAV3 LIN28B TESPA1

9.56e-04184473c294cd421f277992b56ae9c40b8f3948e33148fe
ToppCellTransplant_Alveoli_and_parenchyma-Immune-Mast_cells|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

TESPA1 SMYD3 HS6ST1

9.56e-04184473bc394eaa441fcaffcc4ace062741bca1da229324
ToppCellTransplant_Alveoli_and_parenchyma-Immune-Mast_cells|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

TESPA1 SMYD3 HS6ST1

9.71e-04185473a6e5328801c233a44153420e2cdae644b253f540
ToppCellPCW_13-14-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

VAV3 STAB2 CFI

9.71e-041854733be9e05b929ac4d956b1d53284072f668a6c1959
ToppCell(4)_Mast_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

TESPA1 SMYD3 HS6ST1

9.71e-041854733dd5d2237ab50b13a41c12f85e1b79cd72ea567b
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

VAV3 STAB2 PEAR1

9.71e-04185473f9f48251bc33eb6bf2cff580d1a3207d21450aa0
ToppCellCOVID-19-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

VAV3 STAB2 PEAR1

9.71e-0418547336ce23893915f5c380cca39b2c33a516edf31c3a
ToppCellCOVID-19-Neuronal_cells-Neuronal_cells|COVID-19 / group, cell type (main and fine annotations)

VAV3 STAB2 PEAR1

9.71e-041854734a095829992b39856a73bdfac03ee68b9aa0d3b8
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.4.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

C4BPA CFI SEZ6L2

9.71e-041854737460387f48f33674330bd53b759681b264228f5a
ToppCellPCW_13-14-Endothelial-Endothelial_mature-lymphatic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

VAV3 STAB2 CFI

9.71e-04185473c3dd64a726cb8a1fe048683c266b7532a714a52e
ToppCell(4)_Mast_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

TESPA1 SMYD3 HS6ST1

9.71e-04185473c91e1081e630a61c18f6af6d198bfcf296746852
ToppCelldroplet-Thymus-nan-3m-Lymphocytic-double_negative_T_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HIVEP3 TTC3 TESPA1

9.86e-0418647311929e36d8c9b4c4bc2f5e912f139f474f91ab00
DrugIsoconazole [27523-40-6]; Down 200; 9.6uM; MCF7; HT_HG-U133A

LRP6 ZNF205 ZNF668 UNKL CRIM1 CDK12 FAM3A

1.64e-071994777211_DN
Disease1-Methylhistidine measurement

OTOGL CDK12

2.78e-0417432EFO_0021543
Diseaseeye color

HIVEP3 EYS TTC3

3.10e-0490433EFO_0003949
DiseaseCOVID-19 (is_implicated_in)

C4BPA TLR7

4.28e-0421432DOID:0080600 (is_implicated_in)
Diseasecomplex trait

ZAN LIN28B ZNF689 NCAN

6.48e-04271434EFO_0010578
Diseaseeyelid sagging measurement

EPHB3 SMYD3

1.00e-0332432EFO_0009360
Diseasefactor VIII measurement, venous thromboembolism

C4BPA STAB2

1.13e-0334432EFO_0004286, EFO_0004630
Diseasenasopharyngeal neoplasm

EYS CDK12 FAM3A

1.40e-03151433EFO_0004252
Diseasevenous thromboembolism, von Willebrand factor measurement

C4BPA STAB2

1.72e-0342432EFO_0004286, EFO_0004629
Diseasecoffee consumption measurement

EYS ARL15 SMYD3

2.38e-03182433EFO_0006781
Diseasevon Willebrand factor measurement

STAB2 ADAM32

3.04e-0356432EFO_0004629
Diseaseceramide measurement

EYS ARL15 CDK12

4.87e-03235433EFO_0010222
Diseasepentachlorophenol measurement

EYS TLR7

5.11e-0373432EFO_0022071
Diseaseparathion measurement

EYS TLR7

5.11e-0373432EFO_0022070
Diseasepotassium chromate measurement

EYS TLR7

5.11e-0373432EFO_0022072
Diseasemercuric chloride measurement

EYS TLR7

5.11e-0373432EFO_0022068
Diseaseheptachlor epoxide measurement

EYS TLR7

5.11e-0373432EFO_0022067
Diseasemethoxychlor measurement

EYS TLR7

5.11e-0373432EFO_0022069
Disease4,6-dinitro-o-cresol measurement

EYS TLR7

5.11e-0373432EFO_0022053
Disease2,4,5-trichlorophenol measurement

EYS TLR7

5.11e-0373432EFO_0022052
Diseaseazinphos methyl measurement

EYS TLR7

5.11e-0373432EFO_0022055
Diseasealdrin measurement

EYS TLR7

5.11e-0373432EFO_0022054
Diseasedicofol measurement

EYS TLR7

5.11e-0373432EFO_0022060
Diseasedisulfoton measurement

EYS TLR7

5.11e-0373432EFO_0022062
Diseasedieldrin measurement

EYS TLR7

5.11e-0373432EFO_0022061
Diseaseendrin measurement

EYS TLR7

5.11e-0373432EFO_0022064
Diseaseendosulfan measurement

EYS TLR7

5.11e-0373432EFO_0022063
Diseaseheptachlor measurement

EYS TLR7

5.11e-0373432EFO_0022066
Diseaseethion measurement

EYS TLR7

5.11e-0373432EFO_0022065
Diseasechlorpyrifos measurement

EYS TLR7

5.11e-0373432EFO_0022057
Diseasecadmium chloride measurement

EYS TLR7

5.11e-0373432EFO_0022056
Diseasediazinon measurement

EYS TLR7

5.11e-0373432EFO_0022059
Diseasedibutyl phthalate measurement

EYS TLR7

5.11e-0373432EFO_0022058

Protein segments in the cluster

PeptideGeneStartEntry
PYQGCEALCCPEPKL

C4BPA

356

P04003
CKLPYQCPKNGTAVC

CFI

61

P05156
QPYKKRPKICCPRYG

CDK12

696

Q9NYV4
LCFRALCCKGPPPAR

ARL15

16

Q9NXU5
LYKCTQPPCPNAVDC

GJA10

186

Q969M2
KCHCSPGYKPPNCQI

ADAM32

641

Q8TC27
YQPLCLPFPVCKQLC

RGPD5

511

Q99666
YQPLCLPFPVCKQLC

RGPD8

511

O14715
RFKYVCIPGCTKNPC

EYS

431

Q5T1H1
ECSLPPQPKKCHYCQ

LIN28B

141

Q6ZN17
QPGRYGKRCVPCKCA

PEAR1

611

Q5VY43
CYRALPEPKKCPICR

MUL1

326

Q969V5
PVKPFYQCACPTGVK

LRP6

301

O75581
ESQCRPCPPGSYKAK

EPHB3

281

P54753
YHPTDLCPCPMQKKC

KDM5A

701

P29375
CDCRPGQKKCTCYRP

HS6ST1

116

O60243
CFRCGKPGHYIKNCP

RBBP6

161

Q7Z6E9
APRARKYKCGLPQPC

FAM3A

51

P98173
YQPLCLPLPVCKQLC

RGPD3

511

A6NKT7
PKKCRPIICDKYCPL

CRIM1

536

Q9NZV1
APPGKKYVRCPCNCL

PIP4P1

116

Q86T03
IYPQCVLCPKKGGAL

JADE3

251

Q92613
PQYKCECDPLKCPSI

OTOGL

1966

Q3ZCN5
YQPLCLPLPVCKQLC

RGPD4

511

Q7Z3J3
YVCKKGTVLCGPPPA

NCAN

1206

O14594
PTGKKYVRCPCNCLL

PIP4P2

91

Q8N4L2
VPKCALKYEPCLNPG

SEZ6L2

761

Q6UXD5
ECKCLKSCKPRYPPD

SMYD3

86

Q9H7B4
PRPPGKPFKYKCFQC

ZNF750

16

Q32MQ0
RECVAPNICKCKPGY

VWDE

1306

Q8N2E2
PNICKCKPGYIGSNC

VWDE

1311

Q8N2E2
IPICNPKCLYGGRCI

VWDE

1551

Q8N2E2
TGEKPYKCPLCPYAC

ZNF513

411

Q8N8E2
KPYKCKECGKPFHCP

ZNF441

641

Q8N8Z8
PRPYACPLCPKAYKT

ZNF668

81

Q96K58
PQKPGKYICQYCSRP

HIVEP3

186

Q5T1R4
CKFPPVPDAICCYQK

TTC3

641

P53804
PNKYGPRCNKKCLCV

STAB2

781

Q8WWQ8
FLPCLLCYPPAKGCL

SPRY1

266

O43609
LCYPPAKGCLKLCRR

SPRY1

271

O43609
PRCYNAPFPCAPCKN

TLR7

261

Q9NYK1
GSYKTEQCPKPPRLC

UNKL

206

Q9H9P5
CNRPPCYVPCTKLLV

ZNFX1

1531

Q9P2E3
QNLKKPYPCPDCGRR

ZNF689

171

Q96CS4
KPYPCPECGKCFSQR

ZNF205

446

O95201
KCPTPCQTYVKCPAP

XP32

101

Q5T750
KKLPTSPYPCVFCCE

TESPA1

351

A2RU30
CKKPPRLCRQGYACP

UNK

221

Q9C0B0
KPYPCPQCGRRFGQK

ZNF764

341

Q96H86
CPPNSKYSLCAKPCP

ZAN

1426

Q9Y493
KPCPCVPKPVDYSCQ

VAV3

656

Q9UKW4