Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	IgG immunoglobulin complex	IGLL1 IGLL5	3.04e-04	14	39	2	GO:0071735
Domain	Ubiquilin-1/2	UBQLN2 UBQLN1	3.22e-06	2	34	2	IPR028430
Domain	Ubiquilin	UBQLN2 UBQLN1	4.80e-05	6	34	2	IPR015496
Domain	STI1_HS-bd	UBQLN2 UBQLN1	1.43e-04	10	34	2	IPR006636
Domain	STI1	UBQLN2 UBQLN1	1.43e-04	10	34	2	SM00727
Domain	6-PGluconate_DH_C-like	UBQLN2 UBQLN1	5.39e-04	19	34	2	IPR008927
Domain	UBA	UBQLN2 UBQLN1	1.36e-03	30	34	2	SM00165
Domain	GPS	ADGRE5 PKD1	1.74e-03	34	34	2	SM00303
Domain	GPS	ADGRE5 PKD1	1.84e-03	35	34	2	PF01825
Domain	UBA	UBQLN2 UBQLN1	1.95e-03	36	34	2	PF00627
Domain	GPS	ADGRE5 PKD1	1.95e-03	36	34	2	PS50221
Domain	GPS	ADGRE5 PKD1	2.06e-03	37	34	2	IPR000203
Domain	UBIQUITIN_1	UBQLN2 UBQLN1	2.06e-03	37	34	2	PS00299
Domain	UBQ	UBQLN2 UBQLN1	2.77e-03	43	34	2	SM00213
Domain	UBA	UBQLN2 UBQLN1	2.90e-03	44	34	2	IPR015940
Domain	UBA	UBQLN2 UBQLN1	3.30e-03	47	34	2	PS50030
Domain	ubiquitin	UBQLN2 UBQLN1	3.30e-03	47	34	2	PF00240
Domain	CUB	ADAMTS13 SEZ6L2	4.18e-03	53	34	2	PS01180
Domain	C1-set	IGLL1 IGLL5	4.34e-03	54	34	2	PF07654
Domain	UBIQUITIN_2	UBQLN2 UBQLN1	4.34e-03	54	34	2	PS50053
Domain	IGc1	IGLL1 IGLL5	4.66e-03	56	34	2	SM00407
Domain	CUB_dom	ADAMTS13 SEZ6L2	4.82e-03	57	34	2	IPR000859
Domain	Ig_C1-set	IGLL1 IGLL5	4.99e-03	58	34	2	IPR003597
Domain	Ig/MHC_CS	IGLL1 IGLL5	4.99e-03	58	34	2	IPR003006
Domain	Ubiquitin_dom	UBQLN2 UBQLN1	4.99e-03	58	34	2	IPR000626
Domain	IG_MHC	IGLL1 IGLL5	5.33e-03	60	34	2	PS00290
Domain	RhoGAP	OCRL ARHGAP23	5.68e-03	62	34	2	SM00324
Domain	RhoGAP	OCRL ARHGAP23	5.86e-03	63	34	2	PF00620
Domain	UBA-like	UBQLN2 UBQLN1	6.04e-03	64	34	2	IPR009060
Domain	RHOGAP	OCRL ARHGAP23	6.04e-03	64	34	2	PS50238
Domain	RhoGAP_dom	OCRL ARHGAP23	6.04e-03	64	34	2	IPR000198
Domain	-	OCRL ARHGAP23	6.04e-03	64	34	2	1.10.555.10
Domain	SPRY	SPSB2 RYR3	1.09e-02	87	34	2	SM00449
Domain	Rho_GTPase_activation_prot	OCRL ARHGAP23	1.12e-02	88	34	2	IPR008936
Domain	SPRY	SPSB2 RYR3	1.27e-02	94	34	2	PF00622
Domain	SPRY_dom	SPSB2 RYR3	1.27e-02	94	34	2	IPR003877
Domain	B30.2/SPRY	SPSB2 RYR3	1.29e-02	95	34	2	IPR001870
Domain	B302_SPRY	SPSB2 RYR3	1.29e-02	95	34	2	PS50188
Pubmed	Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution.	IGLL1 IGLJ1 IGLL5	5.21e-09	4	39	3	1703205
Pubmed	Diaphanospondylodysostosis: six new cases and exclusion of the candidate genes, PAX1 and MEOX1.	PAX1 MEOX1	1.23e-06	2	39	2	17764081
Pubmed	A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities.	UBQLN2 UBQLN1	1.23e-06	2	39	2	29247619
Pubmed	Organization and expression of the lambda-like genes that contribute to the mu-psi light chain complex in human pre-B cells.	IGLL1 IGLL5	1.23e-06	2	39	2	1760403
Pubmed	Towards a molecular understanding of the overlapping and distinct roles of UBQLN1 and UBQLN2 in lung cancer progression and metastasis.	UBQLN2 UBQLN1	1.23e-06	2	39	2	35063704
Pubmed	Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy.	UBQLN2 UBQLN1	3.67e-06	3	39	2	20529957
Pubmed	Ubiquitin receptor proteins hHR23a and hPLIC2 interact.	UBQLN2 UBQLN1	3.67e-06	3	39	2	17098253
Pubmed	Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors.	PAX1 MEOX1	7.34e-06	4	39	2	11423130
Pubmed	Analysis of VpreB expression during B lineage differentiation in lambda5-deficient mice.	IGLL1 IGLL5	7.34e-06	4	39	2	11564789
Pubmed	VpreB serves as an invariant surrogate antigen for selecting immunoglobulin antigen-binding sites.	IGLL1 IGLL5	7.34e-06	4	39	2	28217764
Pubmed	Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development.	IGLL1 IGLL5	7.34e-06	4	39	2	8624804
Pubmed	Organization of the murine Ig-related lambda 5 gene transcribed selectively in pre-B lymphocytes.	IGLL1 IGLL5	7.34e-06	4	39	2	3107979
Pubmed	Autoreactive B cell receptors mimic autonomous pre-B cell receptor signaling and induce proliferation of early B cells.	IGLL1 IGLL5	7.34e-06	4	39	2	19084434
Pubmed	Loss of early B cell protein λ5 decreases bone mass and accelerates skeletal aging.	IGLL1 IGLL5	7.34e-06	4	39	2	36189270
Pubmed	Conservation of the immunoglobulin C lambda 5 gene in the Mus gene.	IGLL1 IGLL5	7.34e-06	4	39	2	3129289
Pubmed	The nonimmunoglobulin portion of lambda5 mediates cell-autonomous pre-B cell receptor signaling.	IGLL1 IGLL5	7.34e-06	4	39	2	12897780
Pubmed	PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation.	UBQLN2 UBQLN1	7.34e-06	4	39	2	19148225
Pubmed	Pre-B-cell development in the absence of lambda 5 in transgenic mice expressing a heavy-chain disease protein.	IGLL1 IGLL5	7.34e-06	4	39	2	8548286
Pubmed	Genomic suppression of murine B29/Ig-beta promoter-driven transgenes.	IGLL1 IGLL5	7.34e-06	4	39	2	17111355
Pubmed	Lambda 5, a new light-chain-related locus selectively expressed in pre-B lymphocytes.	IGLL1 IGLL5	7.34e-06	4	39	2	3024017
Pubmed	UBQLN2 undergoes a reversible temperature-induced conformational switch that regulates binding with HSPA1B: ALS/FTD mutations cripple the switch but do not destroy HSPA1B binding.	UBQLN2 UBQLN1	7.34e-06	4	39	2	36423739
Pubmed	A critical role of lambda 5 protein in B cell development.	IGLL1 IGLL5	7.34e-06	4	39	2	1591779
Pubmed	Localization of the murine lambda 5 gene on chromosome 16.	IGLL1 IGLL5	7.34e-06	4	39	2	3128472
Pubmed	B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage.	IGLL1 IGLL5	7.34e-06	4	39	2	31628339
Pubmed	E6AP AZUL interaction with UBQLN1/2 in cells, condensates, and an AlphaFold-NMR integrated structure.	UBQLN2 UBQLN1	7.34e-06	4	39	2	36827983
Pubmed	Dimerization of ubiquilin is dependent upon the central region of the protein: evidence that the monomer, but not the dimer, is involved in binding presenilins.	UBQLN2 UBQLN1	7.34e-06	4	39	2	16813565
Pubmed	Isolation of a cDNA copy of an RNA species expressed in murine pre-B cells.	IGLL1 IGLL5	7.34e-06	4	39	2	2430794
Pubmed	Gamma 2b provides only some of the signals normally given via mu in B cell development.	IGLL1 IGLL5	7.34e-06	4	39	2	9088980
Pubmed	B cell development in mice with a defective lambda 5 gene.	IGLL1 IGLL5	7.34e-06	4	39	2	7684685
Pubmed	Distorted antibody repertoire developed in the absence of pre-B cell receptor formation.	IGLL1 IGLL5	7.34e-06	4	39	2	29191653
Pubmed	lambda 5, but not mu, is required for B cell maturation in a unique gamma 2b transgenic mouse line.	IGLL1 IGLL5	7.34e-06	4	39	2	7869028
Pubmed	A unique role for the lambda5 nonimmunoglobulin tail in early B lymphocyte development.	IGLL1 IGLL5	7.34e-06	4	39	2	18713994
Pubmed	Herp enhances ER-associated protein degradation by recruiting ubiquilins.	UBQLN2 UBQLN1	7.34e-06	4	39	2	18307982
Pubmed	Precursor B cell receptor-dependent B cell proliferation and differentiation does not require the bone marrow or fetal liver environment.	IGLL1 IGLL5	7.34e-06	4	39	2	10620602
Pubmed	Deviation of the B cell pathway in senescent mice is associated with reduced surrogate light chain expression and altered immature B cell generation, phenotype, and light chain expression.	IGLL1 IGLL5	7.34e-06	4	39	2	19109144
Pubmed	The 14.1 surrogate light chain promoter has lineage- and stage-restricted activity.	IGLL1 IGLL5	7.34e-06	4	39	2	9029104
Pubmed	Surrogate light chain is required for central and peripheral B-cell tolerance and inhibits anti-DNA antibody production by marginal zone B cells.	IGLL1 IGLL5	1.22e-05	5	39	2	25546233
Pubmed	The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice.	IGLL1 IGLL5	1.22e-05	5	39	2	8156589
Pubmed	Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin.	UBQLN2 UBQLN1	1.22e-05	5	39	2	15975090
Pubmed	Meox homeodomain proteins are required for Bapx1 expression in the sclerotome and activate its transcription by direct binding to its promoter.	PAX1 MEOX1	1.22e-05	5	39	2	15024065
Pubmed	The murine VpreB1 and VpreB2 genes both encode a protein of the surrogate light chain and are co-expressed during B cell development.	IGLL1 IGLL5	1.22e-05	5	39	2	8625987
Pubmed	Mapping and functional analysis of regulatory sequences in the mouse lambda5-VpreB1 domain.	IGLL1 IGLL5	1.22e-05	5	39	2	15950724
Pubmed	Identification and localization of a developmental stage-specific promoter activity from the murine lambda 5 gene.	IGLL1 IGLL5	1.22e-05	5	39	2	7650380
Pubmed	Induction of pre-B cell proliferation after de novo synthesis of the pre-B cell receptor.	IGLL1 IGLL5	1.22e-05	5	39	2	11172022
Pubmed	Clonal relationships of memory B cell subsets in autoimmune mice.	IGLL1 IGLL5	1.22e-05	5	39	2	36936947
Pubmed	Analysis of mice with single and multiple copies of transgenes reveals a novel arrangement for the lambda5-VpreB1 locus control region.	IGLL1 IGLL5	1.22e-05	5	39	2	9858590
Pubmed	Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development.	IGLL1 IGLL5	1.22e-05	5	39	2	8453664
Pubmed	Identification of three new Ig lambda-like genes in man.	IGLL1 IGLJ1	1.22e-05	5	39	2	3003227
Pubmed	Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane.	UBQLN2 UBQLN1	1.22e-05	5	39	2	10549293
Pubmed	The skewed heavy-chain repertoire in peritoneal B-1 cells is predetermined by the selection via pre-B cell receptor during B cell ontogeny in the fetal liver.	IGLL1 IGLL5	1.22e-05	5	39	2	19011159
Pubmed	The unique and immunoglobulin-like regions of surrogate light chain component lambda5 differentially interrogate immunoglobulin heavy-chain structure.	IGLL1 IGLL5	1.22e-05	5	39	2	20116104
Pubmed	The unique region of surrogate light chain component lambda5 is a heavy chain-specific regulator of precursor B cell receptor signaling.	IGLL1 IGLL5	1.22e-05	5	39	2	15972669
Pubmed	VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus.	IGLL1 IGLL5	1.22e-05	5	39	2	12055243
Pubmed	Formation of an active tissue-specific chromatin domain initiated by epigenetic marking at the embryonic stem cell stage.	IGLL1 IGLL5	1.22e-05	5	39	2	15713636
Pubmed	A prematurely expressed Ig(kappa) transgene, but not V(kappa)J(kappa) gene segment targeted into the Ig(kappa) locus, can rescue B cell development in lambda5-deficient mice.	IGLL1 IGLL5	1.22e-05	5	39	2	8808678
Pubmed	A second gene, VpreB in the lambda 5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes.	IGLL1 IGLL5	1.22e-05	5	39	2	3117530
Pubmed	Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.	UBQLN2 UBQLN1	1.22e-05	5	39	2	11827521
Pubmed	Ig heavy chain protein controls B cell development by regulating germ-line transcription and retargeting V(D)J recombination.	IGLL1 IGLL5	1.83e-05	6	39	2	8046237
Pubmed	Lambda5 is required for rearrangement of the Ig kappa light chain gene in pro-B cell lines.	IGLL1 IGLL5	1.83e-05	6	39	2	10421777
Pubmed	A pre-B- and B cell-specific DNA-binding protein, EBB-1, which binds to the promoter of the VpreB1 gene.	IGLL1 IGLL5	1.83e-05	6	39	2	1730258
Pubmed	The non-Ig parts of the VpreB and λ5 proteins of the surrogate light chain play opposite roles in the surface representation of the precursor B cell receptor.	IGLL1 IGLL5	1.83e-05	6	39	2	22566564
Pubmed	Disruption of the preB Cell Receptor Complex Leads to Decreased Bone Mass.	IGLL1 IGLL5	1.83e-05	6	39	2	31552025
Pubmed	Cutting edge: signaling and cell surface expression of a mu H chain in the absence of lambda 5: a paradigm revisited.	IGLL1 IGLL5	1.83e-05	6	39	2	14500626
Pubmed	RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control.	UBQLN2 UBQLN1	1.83e-05	6	39	2	35247097
Pubmed	Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome.	PAX1 MEOX1	1.83e-05	6	39	2	12490554
Pubmed	Expression of the proliferation-related Ki-67 mRNA in the early development of murine embryo.	IGLL1 IGLL5	1.83e-05	6	39	2	9196061
Pubmed	Identification of a pre-BCR lacking surrogate light chain.	IGLL1 IGLL5	1.83e-05	6	39	2	14638847
Pubmed	System to identify individual somites and their derivatives in the developing mouse embryo.	PAX1 MEOX1	1.83e-05	6	39	2	9389448
Pubmed	The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.	UBQLN2 UBQLN1	2.56e-05	7	39	2	10983987
Pubmed	IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development.	IGLL1 IGLL5	2.56e-05	7	39	2	7526894
Pubmed	Antigenic phenotype and gene expression pattern of lymphohemopoietic progenitors during early mouse ontogeny.	IGLL1 IGLL5	2.56e-05	7	39	2	9058795
Pubmed	Paradox segmentation along inter- and intrasomitic borderlines is followed by dysmorphology of the axial skeleton in the open brain (opb) mouse mutant.	PAX1 MEOX1	2.56e-05	7	39	2	9664688
Pubmed	Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions.	UBQLN2 UBQLN1	2.56e-05	7	39	2	23774650
Pubmed	Mouse mutant "rib-vertebrae" (rv): a defect in somite polarity.	PAX1 MEOX1	2.56e-05	7	39	2	11002339
Pubmed	Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.	UBQLN2 UBQLN1	2.56e-05	7	39	2	27345149
Pubmed	Effect of deregulated IL-7 transgene expression on B lymphocyte development in mice expressing mutated pre-B cell receptors.	IGLL1 IGLL5	2.56e-05	7	39	2	10508254
Pubmed	Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S proteasome-mediated proteolysis.	UBQLN2 UBQLN1	2.56e-05	7	39	2	20059542
Pubmed	In aged mice, low surrogate light chain promotes pro-B-cell apoptotic resistance, compromises the PreBCR checkpoint, and favors generation of autoreactive, phosphorylcholine-specific B cells.	IGLL1 IGLL5	2.56e-05	7	39	2	25727904
Pubmed	The mouse severe combined immune deficiency (scid) mutation is closely linked to the B-cell-specific developmental genes VpreB and lambda 5.	IGLL1 IGLL5	2.56e-05	7	39	2	8100803
Pubmed	Efficient generation of B lymphocytes by recognition of self-antigens.	IGLL1 IGLL5	2.56e-05	7	39	2	21604259
Pubmed	The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.	UBQLN2 UBQLN1	2.56e-05	7	39	2	18199683
Pubmed	Structure of hRpn10 Bound to UBQLN2 UBL Illustrates Basis for Complementarity between Shuttle Factors and Substrates at the Proteasome.	UBQLN2 UBQLN1	2.56e-05	7	39	2	30664872
Pubmed	Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B.	UBQLN2 UBQLN1	2.56e-05	7	39	2	18535780
Pubmed	Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor.	UBQLN1 PKD1	3.42e-05	8	39	2	25907116
Pubmed	Maintenance of somite borders in mice requires the Delta homologue DII1.	PAX1 MEOX1	3.42e-05	8	39	2	9109488
Pubmed	Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery.	UBQLN2 UBQLN1	3.42e-05	8	39	2	23459205
Pubmed	The identification of a nonclassical cadherin expressed during B cell development and its interaction with surrogate light chain.	IGLL1 IGLL5	3.42e-05	8	39	2	10906147
Pubmed	Failure of B-cell differentiation in mice lacking the transcription factor EBF.	IGLL1 IGLL5	4.39e-05	9	39	2	7542362
Pubmed	Severe defects in the formation of epaxial musculature in open brain (opb) mutant mouse embryos.	PAX1 MEOX1	4.39e-05	9	39	2	8565855
Pubmed	The endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls a critical checkpoint in B cell development in mice.	IGLL1 IGLL5	4.39e-05	9	39	2	29907570
Pubmed	Abnormalities of floor plate, notochord and somite differentiation in the loop-tail (Lp) mouse: a model of severe neural tube defects.	PAX1 MEOX1	4.39e-05	9	39	2	9545534
Pubmed	Follistatin interacts with Noggin in the development of the axial skeleton.	PAX1 MEOX1	5.48e-05	10	39	2	24514266
Pubmed	E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements.	IGLL1 IGLL5	5.48e-05	10	39	2	8001125
Pubmed	The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries.	PAX1 MEOX1	5.48e-05	10	39	2	9662403
Pubmed	Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.	UBQLN2 UBQLN1 PRRC2C	5.68e-05	66	39	3	24811749
Pubmed	Genetic Analysis Reveals a Hierarchy of Interactions between Polycystin-Encoding Genes and Genes Controlling Cilia Function during Left-Right Determination.	DAND5 PKD1	6.70e-05	11	39	2	27272319
Pubmed	Functional and molecular analysis of hematopoietic progenitors derived from the aorta-gonad-mesonephros region of the mouse embryo.	IGLL1 IGLL5	6.70e-05	11	39	2	10477673
Pubmed	Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation.	PAX1 MEOX1	6.70e-05	11	39	2	9242490
Pubmed	PAQR9 Modulates BAG6-mediated protein quality control of mislocalized membrane proteins.	UBQLN2 UBQLN1	8.03e-05	12	39	2	31904842
Pubmed	The heat stable antigen (mouse CD24) gene is differentially regulated but has a housekeeping promoter.	IGLL1 IGLL5	9.48e-05	13	39	2	8226859
Interaction	IGLL1 interactions	IGLL1 UBQLN2 IGLL5	1.24e-06	12	37	3	int:IGLL1
Interaction	SMIM2 interactions	UBQLN2 UBQLN1	9.83e-06	3	37	2	int:SMIM2
Interaction	DEFB115 interactions	UBQLN2 UBQLN1	9.83e-06	3	37	2	int:DEFB115
Interaction	FZD7 interactions	ADGRE5 UBQLN2 UBQLN1 SEZ6L2	1.18e-05	77	37	4	int:FZD7
Interaction	PAX1 interactions	PAX1 MEOX1	1.96e-05	4	37	2	int:PAX1
Interaction	GUCA2B interactions	UBQLN2 UBQLN1	3.27e-05	5	37	2	int:GUCA2B
Interaction	C1QTNF4 interactions	UBQLN2 UBQLN1	4.90e-05	6	37	2	int:C1QTNF4
Interaction	SMIM19 interactions	UBQLN2 UBQLN1	6.85e-05	7	37	2	int:SMIM19
Interaction	ASCL1 interactions	EPPK1 UBQLN2 UBQLN1	7.67e-05	45	37	3	int:ASCL1
Interaction	GPR162 interactions	UBQLN2 UBQLN1	9.12e-05	8	37	2	int:GPR162
Interaction	WFDC12 interactions	UBQLN2 UBQLN1	9.12e-05	8	37	2	int:WFDC12
Interaction	NDOR1 interactions	UBQLN2 UBQLN1 MEOX1	1.73e-04	59	37	3	int:NDOR1
Interaction	CDH17 interactions	IGLL1 UBQLN2	1.79e-04	11	37	2	int:CDH17
Interaction	PLAAT3 interactions	UBQLN2 UBQLN1	1.79e-04	11	37	2	int:PLAAT3
Interaction	SEZ6L interactions	UBQLN2 UBQLN1	1.79e-04	11	37	2	int:SEZ6L
Interaction	RTL8A interactions	UBQLN2 UBQLN1	1.79e-04	11	37	2	int:RTL8A
Interaction	PAQR9 interactions	UBQLN2 UBQLN1	1.79e-04	11	37	2	int:PAQR9
Interaction	ZFAND2B interactions	UBQLN2 UBQLN1 PRRC2C	1.81e-04	60	37	3	int:ZFAND2B
Interaction	RNF185 interactions	UBQLN2 UBQLN1 MYADML2 SPSB2	1.96e-04	158	37	4	int:RNF185
Interaction	KRTAP12-1 interactions	NEU4 UBQLN2 TOX	2.10e-04	63	37	3	int:KRTAP12-1
Interaction	ZG16 interactions	UBQLN2 UBQLN1	2.14e-04	12	37	2	int:ZG16
Interaction	PLAAT2 interactions	UBQLN2 UBQLN1	2.53e-04	13	37	2	int:PLAAT2
Interaction	RTL8B interactions	UBQLN2 UBQLN1	2.53e-04	13	37	2	int:RTL8B
Interaction	SOD3 interactions	UBQLN2 UBQLN1	2.53e-04	13	37	2	int:SOD3
Interaction	JPH4 interactions	UBQLN2 UBQLN1 PRRC2C	2.63e-04	68	37	3	int:JPH4
Interaction	CHRNB4 interactions	CNNM1 ADGRE5 UBQLN1	3.11e-04	72	37	3	int:CHRNB4
Interaction	GUCA2A interactions	UBQLN2 UBQLN1	3.87e-04	16	37	2	int:GUCA2A
Interaction	COL9A2 interactions	UBQLN2 UBQLN1	4.38e-04	17	37	2	int:COL9A2
Interaction	NPY interactions	UBQLN2 UBQLN1	4.93e-04	18	37	2	int:NPY
Interaction	NBL1 interactions	UBQLN2 UBQLN1	4.93e-04	18	37	2	int:NBL1
Interaction	SERPINI2 interactions	UBQLN2 UBQLN1	4.93e-04	18	37	2	int:SERPINI2
Interaction	CDIP1 interactions	UBQLN2 UBQLN1	4.93e-04	18	37	2	int:CDIP1
Interaction	PRAP1 interactions	UBQLN2 UBQLN1	4.93e-04	18	37	2	int:PRAP1
Interaction	RBMS1 interactions	CASC3 UBQLN2 UBQLN1 PRRC2C	5.48e-04	207	37	4	int:RBMS1
Interaction	CSN3 interactions	UBQLN2 UBQLN1	5.50e-04	19	37	2	int:CSN3
Interaction	TDRD3 interactions	CASC3 UBQLN1 PRRC2C TRIM56	5.99e-04	212	37	4	int:TDRD3
Interaction	SRGN interactions	UBQLN2 UBQLN1	6.10e-04	20	37	2	int:SRGN
Interaction	PIK3IP1 interactions	UBQLN2 UBQLN1	6.74e-04	21	37	2	int:PIK3IP1
Interaction	KHNYN interactions	UBQLN2 TRIM56	6.74e-04	21	37	2	int:KHNYN
Interaction	PRRC2A interactions	CASC3 UBQLN2 UBQLN1 PRRC2C TRIM56	6.85e-04	389	37	5	int:PRRC2A
Interaction	MEX3B interactions	CASC3 PRRC2C TRIM56 CABLES1	7.12e-04	222	37	4	int:MEX3B
Interaction	SMR3B interactions	UBQLN2 UBQLN1	7.40e-04	22	37	2	int:SMR3B
Interaction	CCL7 interactions	UBQLN2 UBQLN1	7.40e-04	22	37	2	int:CCL7
Interaction	BPIFA1 interactions	ALKBH4 UBQLN2 UBQLN1	7.68e-04	98	37	3	int:BPIFA1
Cytoband	16p13.3	CEMP1 SLX4 PKD1	1.18e-03	244	39	3	16p13.3
GeneFamily	Ubiquilin family	UBQLN2 UBQLN1	1.83e-05	5	25	2	783
GeneFamily	C1-set domain containing	IGLL1 IGLL5	1.53e-03	42	25	2	591
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Hsd11b1_Endou\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ZAR1L TOX HS6ST3 CCDC3	1.09e-05	158	39	4	c8af8964a140acb2987e3b4906d72c546108d229
ToppCell	390C-Epithelial_cells-Epithelial-H_(AT1)\|390C / Donor, Lineage, Cell class and subclass (all cells)	PLEKHH1 PAX1 ADAMTS13 EPPK1	1.15e-05	160	39	4	830f17bad94de05612fe6d53d39e42a4b3f3e2f3
ToppCell	390C-Epithelial_cells-Epithelial-H_(AT1)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	PLEKHH1 PAX1 ADAMTS13 EPPK1	1.15e-05	160	39	4	18ae6822915d16699beb9047baeef9b006901a35
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CA9 ADGRE5 SLC22A3 RYR3	1.91e-05	182	39	4	d3a037268f026eb2f84428b1821022503cef7756
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CA9 ADGRE5 SLC22A3 RYR3	2.03e-05	185	39	4	0b5a0df58ae2ad8261f40f152775747af4f3937a
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	ADGRE5 SLC22A3 RYR3 CCDC3	2.21e-05	189	39	4	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	ZAR1L NEU4 IGLL1 IGLL5	2.71e-05	199	39	4	f30e9d3d095a1e12d759debe27540aad32861db6
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CA9 ADGRE5 SLC22A3 RYR3	2.76e-05	200	39	4	501a3b93624df463458a35d3e6648d4ccc941724
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2-L1-3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CA9 ADGRE5 SLC22A3 RYR3	2.76e-05	200	39	4	d1f36a8232411933b1494168ec912fd0e5246428
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Klk6_(Klk6)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PLEKHH1 NEU4 TEX52	8.14e-05	96	39	3	0fc179af7370a29b7bd5d81e1302a479ae72f196
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE-O2-Trf\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PLEKHH1 NEU4 TEX52	8.14e-05	96	39	3	c301ecfd67ece8bb12be1b94b614957a58046457
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Mbp_(Mbp)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	PLEKHH1 PAX1 TEX52	8.14e-05	96	39	3	9673d03916705c675686bb4282dedd3dc5e98625
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE-O2\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PLEKHH1 NEU4 TEX52	8.14e-05	96	39	3	7d402d543ff159c9bb84c00b083e6e18fc0ff786
ToppCell	Cerebellum-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Klk6_(Klk6)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PLEKHH1 NEU4 TEX52	8.14e-05	96	39	3	a48235df1f5526ce3ffc4c0c2ba038eb20229c55
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Mbp_(Mbp)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	PLEKHH1 PAX1 TEX52	8.14e-05	96	39	3	7e2810f5f5a17fcc7ae40edfd3e885740b575e29
Computational	Neighborhood of CSNK1D	UBQLN2 UBQLN1 PRRC2C	3.07e-05	32	21	3	GCM_CSNK1D
Disease	amyotrophic lateral sclerosis type 15 (implicated_via_orthology)	UBQLN2 UBQLN1	4.34e-06	3	36	2	DOID:0060206 (implicated_via_orthology)
Disease	frontotemporal dementia (implicated_via_orthology)	UBQLN2 UBQLN1	9.48e-05	12	36	2	DOID:9255 (implicated_via_orthology)
Disease	parental longevity	ADGRE5 TOX HS6ST3 SLC22A3 RYR3	3.17e-04	494	36	5	EFO_0007796
Disease	amyotrophic lateral sclerosis (implicated_via_orthology)	UBQLN2 UBQLN1	6.16e-04	30	36	2	DOID:332 (implicated_via_orthology)
Disease	wellbeing measurement, alcohol consumption measurement	TOX CCDC3	3.70e-03	74	36	2	EFO_0007869, EFO_0007878
Disease	monocyte count	ADGRE5 ARHGAP23 KIAA1614 SLC22A3 CABLES1 PKD1	4.88e-03	1320	36	6	EFO_0005091
Disease	mean fractional anisotropy measurement	EPPK1 KIAA1614	6.02e-03	95	36	2	EFO_0008399
Disease	colorectal cancer	UBQLN1 TOX SLC22A3 SPSB2	6.09e-03	604	36	4	MONDO_0005575
Disease	smoking behavior	TOX HS6ST3 CABLES1	8.24e-03	341	36	3	EFO_0004318

Protein segments in the cluster

Peptide	Gene	Start	Entry
CERQRGSDPPWELPP	ALKBH4	26	Q9NXW9
CRCRPGWQPIPGSPN	ADGRE5	186	P48960
AGRARCVWDPPRPQP	ADAMTS13	276	Q76LX8
DPPWPRVSPACAGRF	CA9	146	Q16790
SLQPPAPVWGCLRNP	MEOX1	11	P50221
SGRPEPQSPRPQSWA	DAND5	21	Q8N907
PKRPPNCARGSCPWD	MYADML2	261	A6NDP7
LQPSPQRADPRCWPR	IGLJ1	6	A0A0A0MT76
NGHPPRPWPCPQENR	KIAA1614	46	Q5VZ46
PAPNRPRDDSWSVGP	NEU4	286	Q8WWR8
VPGPARRAQAPPEEW	HS6ST3	51	Q8IZP7
GARPASPQAQPCLWP	PAX1	501	P15863
PQALPQARPCPGRWF	CEMP1	101	Q6PRD7
EAPGEPGPNLRQRWP	IGLL1	11	P15814
LLQPSPQRADPRCWP	IGLL5	71	B9A064
PRYGSPPQRDPNWNG	CASC3	261	O15234
SGEQWQPPRPAPLAA	CABLES1	176	Q8TDN4
DPPNWNIRPNSRADG	CCDC127	6	Q96BQ5
PAPARACQLPSEWRP	CCDC3	16	Q9BQI4
WNRTAPASRGPEPPE	SLC22A3	71	O75751
PPSPGLNWEQPQAAR	PKD1	3521	P98161
PQLQDAWRGPREPGP	EPPK1	2586	P58107
PGPSLRPPNVACWRD	PRRC2C	166	Q9Y520
NDTCPELPPPEWGWR	SEZ6L2	641	Q6UXD5
GPRCPSPQNLSPWDR	PROB1	406	E7EW31
SGLEPWLNCDPNPPD	OCRL	256	Q01968
EGWERAGQCPPPPER	SLX4	511	Q8IY92
RPPGPQRCREQSDWA	CNNM1	126	Q9NRU3
WERGPENLPPSTGPC	RYR3	3146	Q15413
PRDGCSPRRPFPWQG	ARHGAP23	26	Q9P227
PSRTENRDPLPNPWA	UBQLN1	311	Q9UMX0
PNNFARSWPCPNPLP	TEX52	231	A6NCN8
PPPDLGAQRRHGWNP	SPSB2	36	Q99619
NPPTNPPGACQLWEL	PLEKHH1	1331	Q9ULM0
NPDSPRRPWLGCPQD	XNDC1N	26	Q6ZNB5
QPSRTENRDPLPNPW	UBQLN2	306	Q9UHD9
GCRNPPPQPVDWNND	TOX	496	O94900
SPWDGRDPQEPLPAC	ZAR1L	116	A6NP61
RLRQLQGCPWAPGPA	TRIM56	331	Q9BRZ2