Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cytoskeletal protein binding	PDE4B SPATA31A3 MYO9B SYNE1 SPATA31A7 KTN1 CEP57L1 SLC26A5 CKAP5 SPATA31A5 OPA1 CLIP4 NF1 SPATA31A1 XIRP2 ANLN ABRAXAS1 MACF1 ROCK1 UXT TRAPPC14 FRMD3 NIN	1.60e-06	1099	137	23	GO:0008092
GeneOntologyMolecularFunction	diacylglycerol cholinephosphotransferase activity	CEPT1 CHPT1	1.40e-04	3	137	2	GO:0004142
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR1 ITPR3	1.40e-04	3	137	2	GO:0005220
GeneOntologyMolecularFunction	tubulin binding	PDE4B CEP57L1 CKAP5 OPA1 CLIP4 NF1 ABRAXAS1 MACF1 UXT TRAPPC14 NIN	1.82e-04	428	137	11	GO:0015631
GeneOntologyMolecularFunction	microtubule binding	CEP57L1 CKAP5 OPA1 CLIP4 NF1 ABRAXAS1 MACF1 UXT NIN	2.81e-04	308	137	9	GO:0008017
GeneOntologyMolecularFunction	phosphotransferase activity, for other substituted phosphate groups	PIGG CEPT1 CHPT1	4.42e-04	22	137	3	GO:0016780
GeneOntologyBiologicalProcess	regulation of relaxation of cardiac muscle	AKAP6 PDE4B PDE4D	2.34e-05	9	137	3	GO:1901897
GeneOntologyBiologicalProcess	cellular response to cAMP	AKAP6 PDE4D CFTR ITPR1 ITPR3	2.67e-05	53	137	5	GO:0071320
GeneOntologyBiologicalProcess	negative regulation of relaxation of cardiac muscle	PDE4B PDE4D	4.38e-05	2	137	2	GO:1901898
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A5 SPATA31D1	1.20e-06	12	134	4	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A5 SPATA31D1	1.20e-06	12	134	4	IPR027970
Domain	AHD	RTKN2 ANLN	1.53e-04	3	134	2	IPR012966
Domain	Anillin	RTKN2 ANLN	1.53e-04	3	134	2	PF08174
Domain	InsP3_rcpt-bd	ITPR1 ITPR3	1.53e-04	3	134	2	IPR000493
Domain	CHOPT	CEPT1 CHPT1	1.53e-04	3	134	2	IPR014472
Domain	ARM-type_fold	TRPC4AP HEATR4 RTTN CKAP5 TSC2 FRYL LYST ITPR1 NF1 UNC79	1.70e-04	339	134	10	IPR016024
Domain	HA2	TDRD9 DHX30 DHX34	2.72e-04	18	134	3	SM00847
Domain	HA2	TDRD9 DHX30 DHX34	2.72e-04	18	134	3	PF04408
Domain	Helicase-assoc_dom	TDRD9 DHX30 DHX34	2.72e-04	18	134	3	IPR007502
Domain	CDP-OH_P_transf	CEPT1 CHPT1	5.04e-04	5	134	2	PF01066
Domain	CDP-OH_P_trans	CEPT1 CHPT1	5.04e-04	5	134	2	IPR000462
Domain	CDP_ALCOHOL_P_TRANSF	CEPT1 CHPT1	5.04e-04	5	134	2	PS00379
Domain	RIH_assoc-dom	ITPR1 ITPR3	7.52e-04	6	134	2	IPR013662
Domain	Ins145_P3_rec	ITPR1 ITPR3	7.52e-04	6	134	2	PF08709
Domain	RIH_assoc	ITPR1 ITPR3	7.52e-04	6	134	2	PF08454
Domain	RIH_dom	ITPR1 ITPR3	7.52e-04	6	134	2	IPR000699
Domain	Ins145_P3_rcpt	ITPR1 ITPR3	7.52e-04	6	134	2	IPR014821
Domain	Ryanodine_recept-rel	ITPR1 ITPR3	7.52e-04	6	134	2	IPR015925
Domain	-	ITPR1 ITPR3	7.52e-04	6	134	2	1.25.10.30
Domain	RYDR_ITPR	ITPR1 ITPR3	7.52e-04	6	134	2	PF01365
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A3 SPATA31A7 SPATA31A5 SPATA31A1	3.86e-09	6	141	4	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A3 SPATA31A7 SPATA31A5 SPATA31A1	3.86e-09	6	141	4	25930072
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CDR2 TEX2 RALGAPB CKAP5 TSC2 FRYL LYST FSIP2 NF1 SLC12A2 ANLN CEP112 NAV2 MACF1 BOD1L1 TRAPPC14 SRRM2 AHNAK2	1.45e-08	861	141	18	36931259
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	AKAP6 HECW1 SYNE1 RALGAPB ZBTB24 ZNF462 GPR158 NAV2 MACF1 NIN	3.10e-08	225	141	10	12168954
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	AKAP6 PDE4B AHI1 ARHGAP15 TEX2 INPP5B CEP57L1 FRYL ADGRE2 ZBTB24 ITPR1 ORC4 ANLN CEP112 RXFP2 MACF1 ROCK1 BOD1L1	4.43e-07	1084	141	18	11544199
Pubmed	The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice.	PDE4B PDE4D CFTR	6.48e-07	5	141	3	33944911
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TRO SYNE1 DLGAP4 RALGAPB CKAP5 OPA1 DHX30 MACF1 BOD1L1 SRRM2 USP33	9.30e-07	407	141	11	12693553
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	UBQLNL CYP26B1 KRT28 KTN1 LCA5L CKAP5 TSC2 GAL3ST2 IGSF10 PARP4 GTF3C1 BOD1L1 SERPINA9 TMEM200C	1.95e-06	736	141	14	29676528
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A3 SPATA31A7 SPATA31A5 SPATA31A1	2.58e-06	24	141	4	32212159
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	AKAP6 PDE4B SYNE1 CEP57L1 FRYL MACF1 WWC1	2.94e-06	151	141	7	17043677
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	PDE4B HECW1 SYNE1 KTN1 DLGAP4 CKAP5 TSC2 FAM81A OPA1 ZNF462 NF1 GPR158 MACF1 ROCK1 UNC79	9.25e-06	963	141	15	28671696
Pubmed	Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.	AHI1 CKAP5 DHX30 ITPR1 CHPT1 MACF1	1.44e-05	128	141	6	30995482
Pubmed	Effects of PDE4 gene polymorphisms on efficacy and adverse drug events of ritodrine therapy in preterm labor patients: a prospective observational study.	PDE4B PDE4D	1.63e-05	2	141	2	31324945
Pubmed	Overexpression of phosphodiesterase-4 subtypes involved in surgery-induced neuroinflammation and cognitive dysfunction in mice.	PDE4B PDE4D	1.63e-05	2	141	2	28235598
Pubmed	Expression of Cl- channels/transporters in nasal polyps.	CFTR SLC12A2	1.63e-05	2	141	2	32333139
Pubmed	The Pro335 --> Leu polymorphism of type 3 inositol 1,4,5-trisphosphate receptor found in mouse inbred lines results in functional change.	ITPR1 ITPR3	1.63e-05	2	141	2	15890645
Pubmed	Role of Na-K-2Cl cotransporter-1 in gastric secretion of nonacidic fluid and pepsinogen.	CFTR SLC12A2	1.63e-05	2	141	2	16093421
Pubmed	Expression and regulation of the Na+-K+-2Cl- cotransporter NKCC1 in the normal and CFTR-deficient murine colon.	CFTR SLC12A2	1.63e-05	2	141	2	12692180
Pubmed	PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts.	PDE4B PDE4D	1.63e-05	2	141	2	21288894
Pubmed	Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells.	ITPR1 ITPR3	1.63e-05	2	141	2	7559486
Pubmed	Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating.	ITPR1 ITPR3	1.63e-05	2	141	2	20843799
Pubmed	The major sites of cellular phospholipid synthesis and molecular determinants of Fatty Acid and lipid head group specificity.	CEPT1 CHPT1	1.63e-05	2	141	2	12221122
Pubmed	Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4.	PDE4B PDE4D	1.63e-05	2	141	2	29123207
Pubmed	Basolateral chloride transporters in autosomal dominant polycystic kidney disease.	CFTR SLC12A2	1.63e-05	2	141	2	12355171
Pubmed	Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor.	ITPR1 ITPR3	1.63e-05	2	141	2	8663526
Pubmed	Cloning, genomic organization, and characterization of a human cholinephosphotransferase.	CEPT1 CHPT1	1.63e-05	2	141	2	10893425
Pubmed	Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.	ITPR1 ITPR3	1.63e-05	2	141	2	1374893
Pubmed	Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.	PDE4B PDE4D	1.63e-05	2	141	2	15003452
Pubmed	PDE4D plays a critical role in the control of airway smooth muscle contraction.	PDE4B PDE4D	1.63e-05	2	141	2	14519662
Pubmed	Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B).	PDE4B PDE4D	1.63e-05	2	141	2	17700644
Pubmed	PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.	PDE4B PDE4D	1.63e-05	2	141	2	17088426
Pubmed	Chloride transport-driven alveolar fluid secretion is a major contributor to cardiogenic lung edema.	CFTR SLC12A2	1.63e-05	2	141	2	23645634
Pubmed	Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening.	ITPR1 ITPR3	1.63e-05	2	141	2	20813840
Pubmed	Interaction between CFTR and prestin (SLC26A5).	CFTR SLC26A5	1.63e-05	2	141	2	20138822
Pubmed	Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling.	ITPR1 ITPR3	1.63e-05	2	141	2	14707143
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	PDE4D MYO9B CKAP5 FRYL DHX30 ITPR3 PARP4	1.97e-05	202	141	7	33005030
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	AKAP6 SYNE1 KTN1 SPART CLIP4 ZNF462 PARP4 UBE2E1 XIRP2 MACF1	3.78e-05	497	141	10	23414517
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	TEX2 KTN1 TSC2 LYST ITPR1 ITPR3 SLC12A2 TENM1 ZDHHC13 USP33	4.25e-05	504	141	10	34432599
Pubmed	Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.	MYO9B SPATA31A7 CKAP5 FRYL DHX30 SRRM2	4.40e-05	156	141	6	22952844
Pubmed	Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.	ITPR1 ITPR3	4.88e-05	3	141	2	10874040
Pubmed	cAMP-stimulated protein phosphatase 2A activity associated with muscle A kinase-anchoring protein (mAKAP) signaling complexes inhibits the phosphorylation and activity of the cAMP-specific phosphodiesterase PDE4D3.	AKAP6 PDE4D	4.88e-05	3	141	2	20106966
Pubmed	TSC2 modulates cell adhesion and migration via integrin-α1β1.	TSC2 ITGA1	4.88e-05	3	141	2	22923640
Pubmed	Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.	ITPR1 ITPR3	4.88e-05	3	141	2	20395455
Pubmed	Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.	ITPR1 ITPR3	4.88e-05	3	141	2	17437169
Pubmed	Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.	ITPR1 ITPR3	4.88e-05	3	141	2	18547250
Pubmed	Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.	ITPR1 ITPR3	4.88e-05	3	141	2	36350267
Pubmed	The versatility and universality of calcium signalling.	ITPR1 ITPR3	4.88e-05	3	141	2	11413485
Pubmed	Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR3	4.88e-05	3	141	2	26009177
Pubmed	Receptor-activated single channels in intact human platelets.	ITPR1 ITPR3	4.88e-05	3	141	2	1693919
Pubmed	Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.	ITPR1 ITPR3	4.88e-05	3	141	2	23955339
Pubmed	Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.	ITPR1 ITPR3	4.88e-05	3	141	2	31979185
Pubmed	The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).	PDE4B PDE4D	4.88e-05	3	141	2	24555506
Pubmed	Protein kinase A and phosphodiesterase-4D3 binding to coding polymorphisms of cardiac muscle anchoring protein (mAKAP).	AKAP6 PDE4D	4.88e-05	3	141	2	23806656
Pubmed	Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.	ITPR1 ITPR3	4.88e-05	3	141	2	24904548
Pubmed	Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium.	CFTR SLC12A2	4.88e-05	3	141	2	18779379
Pubmed	Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D.	PDE4B PDE4D	4.88e-05	3	141	2	17404263
Pubmed	Electroneutral sodium absorption and electrogenic anion secretion across murine small intestine are regulated in parallel.	CFTR SLC12A2	4.88e-05	3	141	2	15284023
Pubmed	Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages.	PDE4B PDE4D	4.88e-05	3	141	2	16034090
Pubmed	Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis.	ITPR1 ITPR3	4.88e-05	3	141	2	18250332
Pubmed	Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.	ITPR1 ITPR3	4.88e-05	3	141	2	9858485
Pubmed	Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.	ITPR1 ITPR3	4.88e-05	3	141	2	9808793
Pubmed	Identification of KRAP-expressing cells and the functional relevance of KRAP to the subcellular localization of IP3R in the stomach and kidney.	ITPR1 ITPR3	4.88e-05	3	141	2	22992961
Pubmed	Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.	ITPR1 ITPR3	4.88e-05	3	141	2	18194433
Pubmed	Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels.	ITPR1 ITPR3	4.88e-05	3	141	2	12032348
Pubmed	IP3 receptors regulate vascular smooth muscle contractility and hypertension.	ITPR1 ITPR3	4.88e-05	3	141	2	27777977
Pubmed	Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation.	PDE4B PDE4D	4.88e-05	3	141	2	15585880
Pubmed	Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma.	RALB RALGAPB	4.88e-05	3	141	2	34009715
Pubmed	Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.	ITPR1 ITPR3	4.88e-05	3	141	2	17581770
Pubmed	Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.	ITPR1 ITPR3	4.88e-05	3	141	2	18241669
Pubmed	Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.	ITPR1 ITPR3	4.88e-05	3	141	2	19068129
Pubmed	Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect.	PDE4B PDE4D	4.88e-05	3	141	2	10213096
Pubmed	Ubiquitination and proteasomal degradation of endogenous and exogenous inositol 1,4,5-trisphosphate receptors in alpha T3-1 anterior pituitary cells.	ITPR1 ITPR3	4.88e-05	3	141	2	12421829
Pubmed	Differentially expressed genes in giant cell tumor of bone.	KTN1 ROCK1	4.88e-05	3	141	2	21305317
Pubmed	Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR3	4.88e-05	3	141	2	17327232
Pubmed	Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts.	PDE4B PDE4D	4.88e-05	3	141	2	18508768
Pubmed	Detecting Low-Variant Allele Frequency Mosaic Pathogenic Variants of NF1, TSC2, and AKT3 Genes from Blood in Patients with Neurodevelopmental Disorders.	TSC2 NF1	4.88e-05	3	141	2	37088138
Pubmed	Cross-talk between remodeling and de novo pathways maintains phospholipid balance through ubiquitination.	CEPT1 CHPT1	4.88e-05	3	141	2	20018880
Pubmed	Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.	ITPR1 ITPR3	4.88e-05	3	141	2	16014380
Pubmed	Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.	ITPR1 ITPR3	4.88e-05	3	141	2	17890015
Pubmed	Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.	ITPR1 ITPR3	4.88e-05	3	141	2	23983250
Pubmed	Parthenolide inhibits IkappaB kinase, NF-kappaB activation, and inflammatory response in cystic fibrosis cells and mice.	CFTR CHUK	4.88e-05	3	141	2	17272824
Pubmed	Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.	ITPR1 ITPR3	4.88e-05	3	141	2	20427533
Pubmed	Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis.	AHI1 ITPR1 NF1	5.09e-05	18	141	3	33323119
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	RALB TRO SYNE1 IGSF10 FSIP2 SLC12A2	6.64e-05	168	141	6	30631154
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	SYNE1 XIRP2 MACF1	7.07e-05	20	141	3	21689717
Pubmed	Defining the membrane proteome of NK cells.	MYO9B KTN1 CKAP5 PSMD12 PIGG ITGA1 OPA1 ITPR1 ITPR3 PARP4 NF1 GTF3C1 ZDHHC13 DHX34 ATP5F1C	8.42e-05	1168	141	15	19946888
Pubmed	Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.	ITPR1 ITPR3	9.74e-05	4	141	2	25215520
Pubmed	Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.	PDE4B PDE4D	9.74e-05	4	141	2	9371714
Pubmed	Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice.	PDE4B PDE4D	9.74e-05	4	141	2	34943270
Pubmed	The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage.	ITPR1 ITPR3	9.74e-05	4	141	2	23884412
Pubmed	Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice.	PDE4B PDE4D	9.74e-05	4	141	2	21670503
Pubmed	The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.	AKAP6 PDE4D	9.74e-05	4	141	2	16177794
Pubmed	PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.	PDE4B PDE4D	9.74e-05	4	141	2	32738081
Pubmed	A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.	PDE4B PDE4D	9.74e-05	4	141	2	8413254
Pubmed	Cystic fibrosis transmembrane conductance regulator controls lung proteasomal degradation and nuclear factor-kappaB activity in conditions of oxidative stress.	CFTR CHUK	9.74e-05	4	141	2	18372427
Pubmed	Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes.	PDE4B PDE4D	9.74e-05	4	141	2	15644445
Pubmed	mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module.	AKAP6 PDE4D	9.74e-05	4	141	2	11296225
Pubmed	Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion.	PDE4B PDE4D	9.74e-05	4	141	2	22946044
Pubmed	Alternative splice variants of hTrp4 differentially interact with the C-terminal portion of the inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR3	9.74e-05	4	141	2	11163362
Pubmed	Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice.	CFTR ITPR1	9.74e-05	4	141	2	23542070
Interaction	YWHAH interactions	CCDC125 CDR2 TEX2 CFTR RALGAPB CKAP5 TSC2 FRYL LYST NF1 SLC12A2 ANLN CEP112 NAV2 MACF1 BOD1L1 TRAPPC14 SRRM2 WWC1 AHNAK2 NIN	1.23e-05	1102	134	21	int:YWHAH
Interaction	WHAMMP3 interactions	ATF7 CDR2 SYNE1 HAUS3 CHUK WDR17 NIN	1.48e-05	119	134	7	int:WHAMMP3
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	2.59e-04	8	141	2	chr9q12
Cytoband	19p13.1	MYO9B ADGRE2 ADGRE3	4.43e-04	48	141	3	19p13.1
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR1 ITPR3	6.69e-05	3	86	2	297
GeneFamily	CD molecules\|Adhesion G protein-coupled receptors, subfamily E	ADGRE2 ADGRE3	2.22e-04	5	86	2	915
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	TRPC4AP TSC2 ITPR1 ITPR3 SLC12A2 WWC1	2.24e-04	181	86	6	694
GeneFamily	DEAH-box helicases	DHX30 DHX34	2.57e-03	16	86	2	500
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 KTN1 CKAP5 CPED1 LYST TLR8 IGSF10 CHPT1 XIRP2 CEP112 MACF1	1.05e-11	176	140	11	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	AKAP6 RERG PDE4D ITGA1 CPED1 ITPR1 SEMA3D MACF1 ROCK1	8.76e-09	188	140	9	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KTN1 ITGA1 ADGRE2 LYST TLR8 MACF1 PID1 NIN	1.32e-07	185	140	8	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	AKAP6 RERG PDE4D ITGA1 ITPR1 SEMA3D MACF1 ROCK1	1.56e-07	189	140	8	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	AKAP6 RERG SYNE1 ITGA1 CPED1 FAM81A ITPR1 ZFHX3	2.40e-07	200	140	8	c06426f877919bdd267ea2fd7e7973c6619832ae
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VWA3A CFTR ITGA1 SEMA3D TENM1 ZFHX3 FRMD3	1.14e-06	170	140	7	417b77c12a7982b1ce4b4bc57f30335d261220f5
ToppCell	droplet-Marrow-nan-3m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KTN1 ADGRE2 LYST TLR8 MACF1 PID1 NIN	1.80e-06	182	140	7	f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RERG ARHGAP15 ITGA1 CPED1 RXFP2 NAV2 PID1	1.80e-06	182	140	7	44764676ed3f51ba171ce63f669390392fa50a43
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RERG ARHGAP15 ITGA1 CPED1 RXFP2 NAV2 PID1	1.80e-06	182	140	7	d82f59a3f930a840dde27dc6ab024f227a26d446
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	AKAP6 RERG ITGA1 CPED1 ITPR1 SEMA3D ROCK1	1.87e-06	183	140	7	818fd886e0188091310825f9145fa53328f2c979
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AKAP6 SYNE1 CPED1 FAM81A ITPR1 ZFHX3 WDR17	2.08e-06	186	140	7	4780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCell	CV-Moderate-6\|CV / Virus stimulation, Condition and Cluster	AHI1 KTN1 ITPR1 GTF3C1 ROCK1 BOD1L1 SRRM2	2.95e-06	196	140	7	7bced0cc2112697593c478fa291b8ed3941fb811
ToppCell	BL\|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	RALB PDE4B ARHGAP15 ADGRE2 LYST TLR8 NIN	3.05e-06	197	140	7	1acf0191fa0a25cd20bfd9ea7bf727a1555986a1
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AHI1 HECW1 SYNE1 ITPR1 GPR158 NRG3 UNC79	3.15e-06	198	140	7	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	AKAP6 RERG SYNE1 ITGA1 CPED1 ITPR1 ZFHX3	3.37e-06	200	140	7	f599e4b051ac3dad11ad437e98dc8ea6754cca53
ToppCell	LPS_IL1RA-Mesenchymal_myocytic\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	AKAP6 RERG SYNE1 ITGA1 CPED1 ITPR1 ZFHX3	3.37e-06	200	140	7	77631c471cc5d453a749784f838cfa6408caf09b
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RERG HECW1 SYNE1 CPED1 TENM1 NAV2 PID1	3.37e-06	200	140	7	58b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CLIP4 RTKN2 SLC12A2 NAV2 WWC1 USP33	1.25e-05	162	140	6	06f5d6c0bb26fe9d5180bc2ebf2c54bf52e715f3
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CLIP4 RTKN2 SLC12A2 NAV2 WWC1 USP33	1.25e-05	162	140	6	d0d9c18a73bc0bf4f38308ef2eee8ae20f6a7918
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CFTR ITGA1 SEMA3D TENM1 ZFHX3 FRMD3	1.49e-05	167	140	6	a6ff7a3d9b80839c0efa91658836812e868561fa
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	AKAP6 RERG ITGA1 CPED1 SEMA3D ZFHX3	1.82e-05	173	140	6	cb6389536195443633adb06e5f1b7483530773d1
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDR2 FAM81A PTPRZ1 ZFHX3 WDR17 FRMD3	1.88e-05	174	140	6	778e0317c0c63fa4efd74114feb760975b819d92
ToppCell	droplet-Liver-LIVER_HEP-30m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP26B1 KTN1 IGSF10 SEMA3D WDR89 MACF1	2.27e-05	180	140	6	dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCell	droplet-Liver-LIVER_HEP\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP26B1 KTN1 IGSF10 SEMA3D WDR89 MACF1	2.27e-05	180	140	6	423454e3390080ae03bb3cbb267255ebfe4df080
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MARCHF10 SLC26A5 RTKN2 RXFP2 AHNAK2	2.34e-05	108	140	5	d620f07243c2628494e689bbfabc14c453f4b1f4
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AKAP6 ARHGAP15 ITGA1 PTPRZ1 TMEM200C FRMD3	2.34e-05	181	140	6	a436e7e4c36403257ea90160a58ca0d6d7c0cdfc
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	VWA3A RERG SYNE1 ITGA1 CLIP4 NRG3	2.34e-05	181	140	6	5f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	VWA3A RERG SYNE1 ITGA1 CLIP4 NRG3	2.34e-05	181	140	6	c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCell	RA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	AKAP6 RERG PDE4D ITGA1 ITPR1 SEMA3D	2.49e-05	183	140	6	cae2ee08f985a6f005b4b8e959e465350315156a
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HECW1 CFTR DNAH1 XIRP2 TENM1 UNC79	2.57e-05	184	140	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HECW1 CFTR DNAH1 XIRP2 TENM1 UNC79	2.57e-05	184	140	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HECW1 CFTR DNAH1 XIRP2 TENM1 UNC79	2.57e-05	184	140	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	COVID-19-Heart-Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	RERG ARHGAP15 ITGA1 SLC12A2 ZFHX3 FRMD3	2.57e-05	184	140	6	21790cdfa3b4036ad413fd44b94e31563116f25f
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AKAP6 RERG CPED1 FAM81A ZFHX3 WDR17	2.73e-05	186	140	6	a95744b8649096bd7cfc3591a02841fa411085b3
ToppCell	facs-Heart-LA-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RERG INPP5B ITGA1 SLC12A2 ZNF804B EPHX3	2.81e-05	187	140	6	a12f383b02b07af32cc53a154685df8dba8fbd3f
ToppCell	facs-Heart-LA-3m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RERG INPP5B ITGA1 SLC12A2 ZNF804B EPHX3	2.81e-05	187	140	6	c40c152fa14e6afc9188549534b64ccbaded56b3
ToppCell	LA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	RERG ST3GAL5 CD34 NAV2 ZFHX3 PID1	2.81e-05	187	140	6	4ea486991f66c29728d127171a07b81404ec0b78
ToppCell	pdx-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	PDE4D RTTN ITPR1 ZNF462 CEP112 NAV2	2.81e-05	187	140	6	7e376831a11ee72ed87abcdac631ca46ae29c250
ToppCell	human_hepatoblastoma-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	PDE4D RTTN ITPR1 ZNF462 NAV2 UNC79	2.90e-05	188	140	6	b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CCDC125 CFTR CLIP4 ZNF804B WWC1 FRMD3	2.99e-05	189	140	6	7659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCell	ASK440-Immune-T_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	PDE4B PDE4D ARHGAP15 ITGA1 RTKN2 OXNAD1	2.99e-05	189	140	6	868a387d19eb02bf41933e786b7d23e920a5d433
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RERG ITGA1 CPED1 ITPR1 NAV2 PID1	2.99e-05	189	140	6	c734e5693808a0333139e87bd5be2597a9252afe
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	RTTN CPED1 RTKN2 ANLN NAV2 RAD54L	3.08e-05	190	140	6	e83fa8b711aa79a1767818474f1c193b674b1c31
ToppCell	droplet-Heart-nan-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AKAP6 CLIP4 IGSF10 CHPT1 XIRP2 CEP112	3.08e-05	190	140	6	96a92212ea3fb35fa3d0da495e504edc61c71c23
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RERG ITGA1 CPED1 ITPR1 NAV2 PID1	3.17e-05	191	140	6	c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RERG ITGA1 CPED1 ITPR1 NAV2 PID1	3.17e-05	191	140	6	806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RERG SYNE1 ITGA1 CPED1 ITPR1 ZFHX3	3.17e-05	191	140	6	7853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RERG ITGA1 CPED1 ITPR1 NAV2 PID1	3.17e-05	191	140	6	cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RERG ARHGAP15 ITGA1 CPED1 NAV2 PID1	3.26e-05	192	140	6	bc84b9ce01b4d826a682842ab8a395dac9b91183
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNE1 KTN1 ST3GAL5 MACF1 ZFHX3 BOD1L1	3.26e-05	192	140	6	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RERG ARHGAP15 ITGA1 CPED1 NAV2 PID1	3.26e-05	192	140	6	0ab1176cfbb0de8dd1f22c6e2c41265cf6c10ee1
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-myocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE4D SLC30A8 ITGA1 CPED1 SEMA3D AHNAK2	3.36e-05	193	140	6	146e8c148478ab61b1c1dbaf1ee98a8cd4a0ff8a
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	AKAP6 VWA3A MARCHF10 IGSF10 PTPRZ1 AHNAK2	3.36e-05	193	140	6	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	human_hepatoblastoma-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	RTTN CKAP5 RTKN2 ANLN CEP112 RAD54L	3.36e-05	193	140	6	4b9fa2a4424f8abe63fa7bee78db93dda04ab15f
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HECW1 CPED1 RTKN2 ANLN NAV2 RAD54L	3.36e-05	193	140	6	516ea2c12bdc7a5dc676159d627e36f6abe13ef0
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PDE4D ARHGAP15 HAUS3 TENM1 WDR89 OXNAD1	3.46e-05	194	140	6	a44be2f021cfdd0fcdc698c3f04d66db7a1aa6c2
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	VWA3A PDE4D SYNE1 CEP112 NAV2 WWC1	3.56e-05	195	140	6	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4B ARHGAP15 MYO9B ADGRE2 LYST PID1	3.56e-05	195	140	6	10ce1b6961f10372d1f65388cbf3626a5fcd6840
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	VWA3A PDE4D SYNE1 CEP112 NAV2 WWC1	3.56e-05	195	140	6	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC30A8 FRYL NAV2 MACF1 BOD1L1 SRRM2	3.56e-05	195	140	6	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC30A8 FRYL NAV2 MACF1 BOD1L1 SRRM2	3.56e-05	195	140	6	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AHI1 HECW1 SYNE1 GPR158 NRG3 UNC79	3.66e-05	196	140	6	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	VWA3A PDE4D SYNE1 NAV2 MACF1 WWC1	3.66e-05	196	140	6	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	VWA3A PDE4D SYNE1 NAV2 MACF1 WWC1	3.66e-05	196	140	6	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B-B_cell-B_naive\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND5B ARHGAP15 ZNF485 CPED1 ITPR1 ZNF860	3.66e-05	196	140	6	de43dd0697e1daf4d50800957cf0b27b54a7a333
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	AHI1 SLC26A5 RTKN2 ST3GAL5 NAV2 WWC1	3.76e-05	197	140	6	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RERG HECW1 SYNE1 ITGA1 CPED1 NAV2	3.76e-05	197	140	6	0dd71e399f253787fa546a7e90c5373180b89ffd
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AHI1 HECW1 SYNE1 ITPR1 NRG3 UNC79	3.87e-05	198	140	6	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	AHI1 CFTR PGM3 ST3GAL5 NAV2 WWC1	3.87e-05	198	140	6	285f729140b1df029c24f6ca1d2438470ac51794
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AHI1 HECW1 SYNE1 GPR158 NRG3 UNC79	3.87e-05	198	140	6	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AHI1 HECW1 SYNE1 ITPR1 NRG3 UNC79	3.87e-05	198	140	6	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	COVID-19-kidney-Fibroblast-1\|kidney / Disease (COVID-19 only), tissue and cell type	RERG ITGA1 ADGRE2 CPED1 NAV2 PID1	3.98e-05	199	140	6	9503646ff1ad248181146ce767e9d12e882ec3bd
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	AHI1 CFTR PGM3 ST3GAL5 NAV2 WWC1	4.10e-05	200	140	6	e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / Treatment groups by lineage, cell group, cell type	AHI1 SLC26A5 RTKN2 ST3GAL5 NAV2 WWC1	4.10e-05	200	140	6	2dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	AKAP6 SYNE1 ITGA1 CPED1 ITPR1 ZFHX3	4.10e-05	200	140	6	a3a1e35934d676c39f917652e50c502cb2f613c1
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Pericyte\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	AKAP6 RERG SYNE1 ITGA1 CPED1 ZFHX3	4.10e-05	200	140	6	b22cae282591d8dead9869c2adbb9632615f50f7
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PDE4B KTN1 ITGA1 SLC12A2 CD34 MACF1	4.10e-05	200	140	6	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte\|LPS_only / Treatment groups by lineage, cell group, cell type	AKAP6 RERG SYNE1 ITGA1 CPED1 ZFHX3	4.10e-05	200	140	6	8c8ef2b19ab5b1bfc0fae6c38a330f464f28e86f
ToppCell	LPS_only-Mesenchymal_myocytic\|LPS_only / Treatment groups by lineage, cell group, cell type	AKAP6 RERG SYNE1 ITGA1 CPED1 ZFHX3	4.10e-05	200	140	6	8bc9923f82bfb836e2f524204c92050edeae8ca5
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	SYNE1 CPED1 IGSF10 SEMA3D MACF1 FRMD3	4.10e-05	200	140	6	bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_3\|LPS_only / Treatment groups by lineage, cell group, cell type	AKAP6 SYNE1 ITGA1 CPED1 FAM81A ZFHX3	4.10e-05	200	140	6	7c62678cf408aaaf98d6df0fb27814d2007c4521
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SYNE1 CPED1 CD34 TENM1 NAV2 PID1	4.10e-05	200	140	6	0c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RGSL1 HECW1 SLC26A5 NWD2 TENM1	9.54e-05	145	140	5	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	343B-Myeloid-Dendritic-pDC\|343B / Donor, Lineage, Cell class and subclass (all cells)	PDE4B TEX2 FRMD3 LILRA4 NIN	1.34e-04	156	140	5	547e2debfc09c07c049a880dded5fda7dd53e156
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	VWA3A ARHGAP15 SLC26A5 MUC16 CEP112	1.34e-04	156	140	5	10d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell	NS-moderate-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	RTTN ANLN CEP112 TMEM200C RAD54L	1.39e-04	157	140	5	410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCell	Severe-B_naive-5\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	LYST FSIP2 RTKN2 UBE2E1 FRMD3	1.39e-04	157	140	5	a57ee4a6febdff3ee3d1645836695e6e7c055cf8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA1 ADGRE2 CPED1 PID1 LILRA4	1.47e-04	159	140	5	e812cbde59188924c6277c3feadf1a9592fa62a4
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA1 ADGRE2 CPED1 PID1 LILRA4	1.47e-04	159	140	5	2607b562903228274fbd96168ba826782fab0b53
ToppCell	Club_cells-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	UBQLNL TRO C2orf15 ACSM6 WWC1	1.51e-04	160	140	5	b261a3a49c850d92bc9e04fc3527c752dfe37a1a
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA3A CFTR PTPRZ1 RXFP2 WDR17	1.51e-04	160	140	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a7\|Thalamus / BrainAtlas - Mouse McCarroll V32	TDRD9 TEX2 DNAH1 NWD2 RXFP2	1.51e-04	160	140	5	7d34159363d274019e14549d1186c629ce990691
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA3A CFTR PTPRZ1 RXFP2 WDR17	1.51e-04	160	140	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a7-Tac2\|Thalamus / BrainAtlas - Mouse McCarroll V32	TDRD9 TEX2 DNAH1 NWD2 RXFP2	1.51e-04	160	140	5	fe5fb0e7a79862f63529721f0a82f4f6d231d3ca
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)\|Thalamus / BrainAtlas - Mouse McCarroll V32	AHI1 TEX2 CFTR DNAH1 NWD2	1.56e-04	161	140	5	0605134a342d74ae81f33700d6ddfcd6e03aeb7b
ToppCell	ASK428-Immune-Mast_cell\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	ARHGAP15 ADGRE2 CATSPER1 TENM1 AHNAK2	1.65e-04	163	140	5	569ca0e8ce307f258910b0c75c498009a9651e6e
ToppCell	mild-Myeloid-Eosinophils\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	PDE4D MYO9B INPP5B SYNE1 ADGRE3	1.65e-04	163	140	5	7c57d541a88e9afa079e95b8a6ecdea60a0c6aaa
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CEP57L1 TLR8 ZNF100 NR1H2 BOD1L1	1.85e-04	167	140	5	a54b8e03987a7b067173121902e1811a3d003692
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VWA3A CFTR ITGA1 SEMA3D ZFHX3	1.90e-04	168	140	5	217770a94ace446cdfc7687b459dece707576e76
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VWA3A SEMA3D TENM1 ZFHX3 FRMD3	1.90e-04	168	140	5	7abaddbcc55e44653d54aa15464266aa6bd5c9d2
Drug	basic copper carbonate	ITPR1 ITPR3 ANLN	1.12e-05	8	135	3	CID000025503
Drug	Ns 004	CFTR ITPR1 ITPR3	1.12e-05	8	135	3	CID000162750
Drug	trequinsin	PDE4B PDE4D CFTR	1.67e-05	9	135	3	ctd:C035964
Drug	L-826,141	PDE4B PDE4D CFTR	1.67e-05	9	135	3	ctd:C459562
Drug	Josamycin [16846-24-5]; Down 200; 4.8uM; HL60; HG-U133A	KTN1 SPART TSC2 OPA1 MACF1 NR1H2 ZDHHC13 DHX34	2.36e-05	197	135	8	2034_DN
Drug	Pentylenetetrazole [54-95-5]; Up 200; 29uM; MCF7; HT_HG-U133A	DENND5B AHI1 ADCK2 ITPR1 ITPR3 NF1 MACF1 DHX34	2.36e-05	197	135	8	5508_UP
Drug	IAA-94	CFTR ITPR1 ITPR3 CATSPER1 SLC12A2	3.10e-05	61	135	5	CID000003667
Drug	V11294 Analogue 5f	PDE4B PDE4D	3.49e-05	2	135	2	CID011214587
Drug	V11294 Analogue 5t	PDE4B PDE4D	3.49e-05	2	135	2	CID011226695
Drug	V11294 Analogue 5e	PDE4B PDE4D	3.49e-05	2	135	2	CID011443441
Drug	V11294 Analogue 5n	PDE4B PDE4D	3.49e-05	2	135	2	CID011238279
Drug	V11294 Analogue 5p	PDE4B PDE4D	3.49e-05	2	135	2	CID011478659
Drug	V11294 Analogue 5o	PDE4B PDE4D	3.49e-05	2	135	2	CID011249748
Drug	V11294 Analogue 5c	PDE4B PDE4D	3.49e-05	2	135	2	CID011179896
Drug	V11294 Analogue 5b	PDE4B PDE4D	3.49e-05	2	135	2	CID011443760
Drug	Cis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid	PDE4B PDE4D	3.49e-05	2	135	2	DB03849
Drug	T-2585.HCl	PDE4B PDE4D	3.49e-05	2	135	2	CID006918355
Drug	(2-(trimethylammonium)ethyl)methanethiosulfonate	CFTR SLC12A2	3.49e-05	2	135	2	ctd:C109154
Drug	Isocaffeine	ITPR1 ITPR3	3.49e-05	2	135	2	CID000001326
Drug	V11294 Analogue 5m	PDE4B PDE4D	3.49e-05	2	135	2	CID011477773
Drug	V11294 Analogue 8a	PDE4B PDE4D	3.49e-05	2	135	2	CID011442865
Drug	V11294 Analogue 5q	PDE4B PDE4D	3.49e-05	2	135	2	CID011318772
Drug	V11294 Analogue 5h	PDE4B PDE4D	3.49e-05	2	135	2	CID011306698
Drug	adenophostin B	ITPR1 ITPR3	3.49e-05	2	135	2	CID000656722
Drug	3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester	PDE4B PDE4D	3.49e-05	2	135	2	DB01959
Drug	4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone	PDE4B PDE4D	3.49e-05	2	135	2	DB01954
Drug	M 98	PDE4B PDE4D	3.49e-05	2	135	2	CID006420180
Drug	V11294 Analogue 5i	PDE4B PDE4D	3.49e-05	2	135	2	CID011376249
Drug	V11294 Analogue 5d	PDE4B PDE4D	3.49e-05	2	135	2	CID011283750
Drug	3-cyclopentyloxy-4-methoxybenzoic acid	PDE4B PDE4D	3.49e-05	2	135	2	CID002779323
Drug	V11294 Analogue 5v	PDE4B PDE4D	3.49e-05	2	135	2	CID011375325
Drug	3-cyclopentyloxy-4-methoxybenzaldehyde	PDE4B PDE4D	3.49e-05	2	135	2	CID002735893
Drug	Np-V	PDE4B PDE4D	3.49e-05	2	135	2	CID009999276
Drug	(S)-Rolipram	PDE4B PDE4D	3.49e-05	2	135	2	DB03606
Drug	1-((5-(1-aminoethyl)-2-(8-methoxy-2-(triflurormethyl)-5-quinolinyl)-4-oxazolyl) carbonyl)-4-((cyclopropylcarbonyl)amino)proline ethyl ester	PDE4B PDE4D	3.49e-05	2	135	2	ctd:C554440
Drug	V11294 Analogue 5r	PDE4B PDE4D	3.49e-05	2	135	2	CID011168555
Drug	V11294 Analogue 5j	PDE4B PDE4D	3.49e-05	2	135	2	CID011433797
Drug	V11294 Analogue 5a	PDE4B PDE4D	3.49e-05	2	135	2	CID011386897
Drug	V11294 Analogue 5k	PDE4B PDE4D	3.49e-05	2	135	2	CID011456440
Drug	benzene 1,2,4-trisphosphate	ITPR1 ITPR3	3.49e-05	2	135	2	CID000192376
Drug	(R)-Rolipram	PDE4B PDE4D	3.49e-05	2	135	2	DB04149
Drug	felodipine	PDE4B PDE4D CYP26B1 CFTR ITPR1 ITPR3 CATSPER1	6.84e-05	169	135	7	CID000003333
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A	CYP26B1 ADGRE2 LYST ITPR1 ST3GAL5 CEP112 AHNAK2	9.47e-05	178	135	7	6454_UP
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A	CYP26B1 LYST ITPR1 ST3GAL5 CEP112 PID1 AHNAK2	1.02e-04	180	135	7	5484_UP
Drug	5-deoxy-5-fluoro-myo-inositol	ITPR1 ITPR3	1.04e-04	3	135	2	CID000195110
Drug	BW A78U	PDE4B PDE4D	1.04e-04	3	135	2	CID000127779
Drug	4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid	PDE4B PDE4D	1.04e-04	3	135	2	DB08299
Drug	Org 4428	PDE4B PDE4D	1.04e-04	3	135	2	CID000166560
Drug	1-Pyrrolidinebutanenitrile	PDE4B PDE4D	1.04e-04	3	135	2	CID000118838
Drug	Bumetanide	CFTR F2RL1 SLC12A2	1.08e-04	16	135	3	ctd:D002034
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A	CYP26B1 SYNE1 LYST ITPR1 ST3GAL5 CEP112 AHNAK2	1.16e-04	184	135	7	3643_UP
Drug	Zardaverine [101975-10-4]; Up 200; 15uM; PC3; HT_HG-U133A	PDE4B AHI1 SPART ADCK2 ITGA1 ITPR1 ADGRE3	1.29e-04	187	135	7	4209_UP
Drug	Securinine [5610-40-2]; Up 200; 18.4uM; HL60; HT_HG-U133A	TRPC4AP PDE4D INSL5 ITPR3 NF1 CEP112 CD34	1.38e-04	189	135	7	2729_UP
Drug	Calycanthine [595-05-1]; Up 200; 11.6uM; MCF7; HT_HG-U133A	DENND5B SYNE1 ITPR1 NF1 ST3GAL5 CEP112 AHNAK2	1.57e-04	193	135	7	2764_UP
Drug	2gst	TSC2 ADGRE2 ITPR1 ITPR3 ADGRE3	1.61e-04	86	135	5	CID000444461
Drug	(-)-Eseroline fumarate salt [104015-29-4]; Up 200; 12uM; PC3; HT_HG-U133A	AHI1 PDE4D MYO9B INPP5B CEP112 NAV2 DHX34	1.78e-04	197	135	7	7267_UP
Drug	Cephalexin monohydrate [23325-78-2]; Up 200; 11uM; MCF7; HT_HG-U133A	HECW1 ADCK2 ITPR1 CD34 LILRA4 IMPG2 AHNAK2	1.78e-04	197	135	7	5250_UP
Drug	Deptropine citrate [2169-75-7]; Down 200; 7.6uM; PC3; HT_HG-U133A	DENND5B INPP5B ADCK2 ITGA1 ITPR1 GTF3C1 SRRM2	1.78e-04	197	135	7	5118_DN
Drug	5286656; Down 200; 50uM; MCF7; HT_HG-U133A_EA	TRPC4AP MYO9B INPP5B ORC4 NF1 ST3GAL5 TRAPPC14	1.83e-04	198	135	7	889_DN
Drug	Buspirone hydrochloride [33386-08-2]; Up 200; 9.4uM; PC3; HT_HG-U133A	PDE4B HECW1 ADCK2 ADGRE2 CPED1 TLR8 NF1	1.83e-04	198	135	7	6743_UP
Drug	Pronethalol hydrochloride [51-02-5]; Up 200; 15uM; MCF7; HT_HG-U133A	CYP26B1 SYNE1 DLGAP4 ADCK2 TRAPPC14 WWC1 AHNAK2	1.83e-04	198	135	7	4104_UP
Drug	Dehydrocholic acid [81-23-2]; Up 200; 9.6uM; MCF7; HT_HG-U133A	AKAP6 PDE4D INPP5B ITPR1 NF1 DHX34 AHNAK2	1.83e-04	198	135	7	1523_UP
Drug	Trimetazidine dihydrochloride [13171-25-0]; Down 200; 11.8uM; HL60; HG-U133A	RALB KTN1 RALGAPB SPART LYST OPA1 GTF3C1	1.89e-04	199	135	7	1727_DN
Drug	Pipemidic acid [51940-44-4]; Up 200; 13.2uM; MCF7; HT_HG-U133A	DENND5B CYP26B1 MYO9B ADGRE2 ITPR1 NF1 CEP112	1.95e-04	200	135	7	6470_UP
Drug	flufenamic acid; Down 200; 10uM; MCF7; HG-U133A	CYP26B1 MYO9B PGM3 ITPR3 ORC4 DHX34 WWC1	1.95e-04	200	135	7	316_DN
Drug	Piclamilast	PDE4B PDE4D	2.08e-04	4	135	2	DB01791
Drug	CHEBI:697555	ITPR1 ITPR3	2.08e-04	4	135	2	CID009578246
Drug	dihydropinosylvin	CFTR LYST	2.08e-04	4	135	2	CID000442700
Drug	diquafosol	PDE4B PDE4D CFTR	2.16e-04	20	135	3	CID000148196
Disease	Intellectual Disability	AKAP6 AHI1 SYNE1 RTTN ZBTB24 PGM3 ZNF462 NF1 ST3GAL5 MACF1	3.95e-05	447	134	10	C3714756
Disease	sphingomyelin 14:0 measurement	PDE4D WDR89 ZFHX3	5.94e-05	17	134	3	EFO_0010390
Disease	urate measurement, bone density	AKAP6 CDR2 ARHGAP15 SYNE1 SLC26A5 ITPR1 DNAH1 FSIP2 CD34 ADGRE3 ACSM6	1.27e-04	619	134	11	EFO_0003923, EFO_0004531
Disease	retinal disease (implicated_via_orthology)	CEPT1 CHPT1	3.03e-04	6	134	2	DOID:5679 (implicated_via_orthology)
Disease	cancer antigen 125 measurement	MUC16 GAL3ST2	8.99e-04	10	134	2	EFO_0010603
Disease	alcohol use disorder measurement, alcohol consumption measurement	PDE4B ARHGAP15 NF1 ZFHX3	1.02e-03	97	134	4	EFO_0007878, EFO_0009458
Disease	nucleus accumbens volume change measurement	MUC16 WWC1	1.10e-03	11	134	2	EFO_0021493
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR1 ITPR3	1.31e-03	12	134	2	DOID:1441 (implicated_via_orthology)
Disease	Diverticular Bleeding	ARHGAP15 GPR158	1.55e-03	13	134	2	C4505353
Disease	Diverticular Diseases	ARHGAP15 GPR158	1.55e-03	13	134	2	C4317009
Disease	age at menopause	ZNF729 FRYL OPA1 CHUK ABRAXAS1 BOD1L1	2.63e-03	302	134	6	EFO_0004704
Disease	copine-1 measurement	TRPC4AP DLGAP4	2.66e-03	17	134	2	EFO_0008102
Disease	esophageal adenocarcinoma	HECW1 CFTR	2.99e-03	18	134	2	EFO_0000478
Disease	verbal-numerical reasoning measurement	AKAP6 ARHGAP15 GPR158 WDR17	3.05e-03	131	134	4	EFO_0008394
Disease	rheumatoid arthritis, COVID-19	INPP5B FRYL ITPR3	3.12e-03	64	134	3	EFO_0000685, MONDO_0100096
Disease	pulse pressure measurement	LYPLAL1 TEX2 INPP5B DLGAP4 LCA5L CKAP5 FRYL ITGA1 ARMS2 SLC12A2 RXFP2 ZFHX3 DHX34 NIN	4.43e-03	1392	134	14	EFO_0005763
Disease	total blood protein measurement	TRPC4AP ITGA1 DNAH1 CD34 MACF1 ROCK1 IMPG2	4.53e-03	449	134	7	EFO_0004536

Protein segments in the cluster

Peptide	Gene	Start	Entry
SCVMSLKNRHVSKSS	ABRAXAS1	296	Q6UWZ7
SKSATQVSAIHMDSK	C2orf15	6	Q8WU43
MTQLSKKAASILSDT	ACSM6	91	Q6P461
ASDKQRSKLSLSHSM	ARMS2	51	P0C7Q2
KQTKSTIGVMVTASH	PGM3	51	O95394
SSLLSSVFKLLMTHK	ADCK2	566	Q7Z695
ANKTRILVTSKMEHL	CFTR	596	P13569
QMSKKVHTQDISTKH	CATSPER1	376	Q8NEC5
MQLKPSTSSHLLKTV	CPED1	221	A4D0V7
FVHTESSSTKMQLVK	AHI1	966	Q8N157
IRKLKTESEMHTLSS	ADGRE2	796	Q9UHX3
LKQEHALSASKASSM	CEP112	491	Q8N8E3
AKMRLKATLTHQVSS	ATF7	256	P17544
MQFHTVGTKTKLSTL	DHX30	266	Q7L2E3
HVTSKVNTGLMTSKK	CLIP4	381	Q8N3C7
GHMLKTTKNNTTELT	DLGAP4	251	Q9Y2H0
SIVKLVKSSHHNMLL	NWD2	1276	Q9ULI1
SKGQSSLALHKVIMV	RALB	6	P11234
KMSVSSLSSITSLKK	RAD54L	441	Q92698
LSISEQSTKLKMSHR	FAM81A	191	Q8TBF8
QDKLNSTMKLVSHLT	ITPR3	2626	Q14573
STMAKSENLVKSHVQ	NRG3	411	P56975
MSSRKSKSNSLIHTE	ORC4	1	O43929
TSLVTHSEAKMISAI	MUC16	11181	Q8WXI7
ANSLHTSKMKTLTRV	C20orf96	46	Q9NUD7
SRIHSIEEKTSKMTN	KRT28	441	Q7Z3Y7
SMSRHILKTLESENK	LILRA4	66	P59901
LFLKSHSIVQKTAMN	ITPR1	1571	Q14643
VATLHSQLKSLSSSM	WWC1	416	Q8IX03
TSMLQKSLSVIASAK	GPR158	896	Q5T848
VFTSSTCLKHMILKV	HECW1	976	Q76N89
KIVHILNMTSAKIIS	CHUK	311	O15111
LTSITTKSNIHSSVM	ANLN	911	Q9NQW6
TASASTSLIMQLLKH	CYP26B1	301	Q9NR63
KSASKMDTTLINISA	KIAA1109	4231	Q2LD37
SDSMLTIISHSLVKS	FSIP2	3836	Q5CZC0
TIISHSLVKSLMDKL	FSIP2	3841	Q5CZC0
SLVKSLMDKLSHSIQ	FSIP2	3846	Q5CZC0
SGTHFQTMLKSKLNV	PID1	41	Q7Z2X4
TQISGVKKLMHSSSL	PDE4B	306	Q07343
VKKLMHSSSLNNTSI	PDE4B	311	Q07343
GVKKLMHSSSLTNSS	PDE4D	366	Q08499
STQEMTVHLLSKLIS	FRYL	2071	O94915
SHKTIKQMQSSFTSS	KTN1	1171	Q86UP2
THKLSIITTKMDAND	LCA5L	261	O95447
KLNSLMSLVNKTTHL	PSMD12	431	O00232
KISSTMLHLIVSNSA	PTPRZ1	1216	P23471
TSHEMKKQTLKSLII	PARP4	1146	Q9UKK3
KMTTSTDHLKRGTIL	ITGA1	1046	P56199
KIEIISHMKQSTSCL	MACF1	2921	Q9UPN3
SKKHSVMSRQDLQTL	INSL5	106	Q9Y5Q6
SVTSKMLINFLSKNH	OR5AC1	76	P0C628
STLRHLTLTSIMKSK	OXNAD1	31	Q96HP4
SKLLKTSMLKAHQVT	OPA1	526	O60313
TVKQMQVSLTSKKHS	F2RL1	366	P55085
STLTKKMHIQSAVSK	BOD1L1	1201	Q8NFC6
VTNIMFLKTHKTASS	GAL3ST2	51	Q9H3Q3
TQKEKKAMLAFHTST	FRMD3	276	A2A2Y4
NKVTAMSLFHSSLSK	DNAH1	521	Q9P2D7
VASSTDMLHSKLSQL	CKAP5	1971	Q14008
VSAKITNKLVVAHMT	CEPT1	326	Q9Y6K0
LSTAIKTTAMSKNIN	IGSF10	861	Q6WRI0
RHSQLKSSSKSQALM	CARD6	686	Q9BX69
KATSHTQAVLQKTME	CCDC125	156	Q86Z20
EHLKKTVTMLQAQLS	CDR2	196	Q01850
SNSVSLKMGHVKLVS	C19orf44	321	Q9H6X5
KTTLIHTMLAVELNS	HEATR4	626	Q86WZ0
LHCSESTSKLKNMVL	DENND5B	411	Q6ZUT9
MASVTSHKSLRLNAK	HAUS3	126	Q68CZ6
LIHLKASNSSMKSSI	HAUS3	276	Q68CZ6
STVKKVKSEQLHHSM	LYST	481	Q99698
MSDFQILKTTLTHRK	EPHX3	236	Q9H6B9
QTSVKQKHKSTMTVR	MARCHF10	101	Q8NA82
NSMLKSLGVTTKFHS	LYPLAL1	191	Q5VWZ2
TITVSDKAHILSMQK	INPP5B	306	P32019
IHSSIAKQMKSEVAT	ATP5F1C	106	P36542
ISKIIMSSVSNLKHS	CEP57L1	226	Q8IYX8
KMSSKHQLLSFVSLL	DHX34	871	Q14147
TEISSKLQLMKKHQS	CD34	251	P28906
HDVTQSKLFSLKTSM	C18orf63	461	Q68DL7
SQTSSLDTKLSTLMH	RTKN2	536	Q8IZC4
STEDILTLKITHMAS	RTTN	1056	Q86VV8
MKVHIKALQTVTSFL	TAS2R46	221	P59540
LSKVFSAMLAIHSNK	UTP6	126	Q9NYH9
STLLTLQGHVMKSIE	RGSL1	731	A5PLK6
QILSHLSSELKEMST	SRRM2	1251	Q9UQ35
TLMTSKKTFLQTATL	TRPC4AP	196	Q8TEL6
QLKELTSTVRKEHMT	SYNE1	3796	Q8NF91
TNKEKLIMISRSHAI	TMEM200C	596	A6NKL6
MSQLKVSLELSVHSA	TDRD9	836	Q8NDG6
AKSSLLEHRIATMKQ	NIN	1731	Q8N4C6
FSVTISMAKTLANKH	SLC26A5	351	P58743
LMKLVSLRTLSSVHS	NR1H2	421	P55055
MASLRKQVLTKASDH	SPATA31A7	866	Q8IWB4
LSVKHSATVSMLSVK	NAV2	386	Q8IVL1
IVAKASKNLMSTQSL	ARHGAP15	416	Q53QZ3
QTMHNVTTETKFLLK	ST3GAL5	386	Q9UNP4
SFIKAENTTHAMSIK	RXFP2	441	Q8WXD0
DLNQVITTTVMKHTK	TENM1	2086	Q9UKZ4
ITTTVMKHTKIFSAN	TENM1	2091	Q9UKZ4
HAIMSEHKKTITAIS	WDR17	76	Q8IZU2
SESVEHRSLIMKKLT	IMPG2	156	Q9BZV3
KCSHITTITSSQKFM	SIX6OS1	336	Q8N1H7
MLSLGAHSVTKTQIL	SERPINA9	81	Q86WD7
SSTTHVKQAINKMLT	RERG	181	Q96A58
KHSSIILNMELSLKQ	SEMA3D	501	O95025
ESHSATKSALIQKLM	AKAP6	751	Q13023
SLSKSVTLTFQHVKM	ADGRE3	281	Q9BY15
SMTNTTKIQLIHDEK	AHNAK2	641	Q8IVF2
IAMQSSATHLTSKRT	CCDC15	116	Q0P6D6
AKVSQKLVVAHMTKS	CHPT1	306	Q8WUD6
VHLKSQDFLMKTNTS	XIRP2	2071	A4UGR9
ESQIVESKMKTSSSH	XIRP2	3251	A4UGR9
MASLRKQVLTKASDH	SPATA31A3	866	Q5VYP0
SQQSKAKLMSSSVVV	UHRF1BP1L	446	A0JNW5
LETKTTTKLSMLELH	TLR8	756	Q9NR97
KAFNESSNLTTHKMI	ZNF100	436	Q8IYN0
KALSKSFTMHSLTIQ	SLC30A8	336	Q8IWU4
AMVKKTATQTGHTLL	SPART	611	Q8N0X7
KDFSVILKSNHISMT	ZNF804B	671	A4D1E1
ILKSNHISMTSKVSG	ZNF804B	676	A4D1E1
ISLQKQSKHMKQTLS	ZDHHC13	556	Q8IUH4
SNSLTKDSMNIKAHI	UXT	121	Q9UBK9
MASLRKQVLTKASDH	SPATA31A1	866	Q5TZJ5
MASLRKQVLTKASDH	SPATA31A5	866	Q5VU36
SVLLMHTLLAATKDS	TRO	41	Q12816
LSQHMKLKLQFTASV	TRAPPC14	466	Q8WVR3
SVKQTMSLPEKSHSQ	SPATA31D1	856	Q6ZQQ2
LKEHSSTANIIVMSL	SLC12A2	1156	P55011
ICKKLTSHQMLSSTE	NF1	581	P21359
KVVSLLDSTSSMHNK	RHPN2P1	486	A8MT19
KVNHTSKANTAMIST	UBQLNL	351	Q8IYU4
HRAVTVNKATMKTST	RALGAPB	386	Q86X10
VNKATMKTSTVSTAH	RALGAPB	391	Q86X10
MKTSTVSTAHASKVQ	RALGAPB	396	Q86X10
KSHTEMSKSISQLES	ROCK1	566	Q13464
SKALTTKHSLLEHMS	ZBTB24	356	O43167
STMTISQLKEHSLKV	ZNF462	2091	Q96JM2
RNSHEATMTQIKKLT	ZNF860	121	A6NHJ4
TFTKKESMKIASSVH	WDR89	356	Q96FK6
SSHLVLVTFKKAVTM	WDCP	316	Q9H6R7
SVLMKIHTSLQSKER	PIGG	241	Q5H8A4
RHLMKTLVKSLSTDT	TEX2	211	Q8IWB9
KLSVMLSTRTNHIET	GTF3C1	261	Q12789
VSMSKNSKLLSTSAK	UBE2E1	36	P51965
KMSALKQSTSEASVL	ZNF485	91	Q8NCK3
MTGSNSHITILTLKV	USP33	1	Q8TEY7
ILQKTVSSTIHEKAM	VWA3A	441	A6NCI4
LVVKLTHISATASMA	TSC2	826	P49815
FNSSSTLMKHKIIHT	ZNF729	441	A6NN14
STKAKLNLIQHVRSM	ZFHX3	1096	Q15911
HTLTKLKSHMKTCSQ	UNC79	2336	Q9P2D8
LIISMTLHDRTTKSL	MYO9B	801	Q13459