Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionendoribonuclease activity, cleaving miRNA-paired mRNA

AGO2 AGO3

6.65e-062522GO:0090624
GeneOntologyMolecularFunctionpromoter-specific chromatin binding

ZNF750 ZNF609 IRF3 NIPBL

6.45e-0583524GO:1990841
GeneOntologyMolecularFunctionmiRNA binding

AGO2 AGO4 AGO3

2.65e-0448523GO:0035198
GeneOntologyMolecularFunctionacetylcholine binding

CHRFAM7A CHRNA7

5.09e-0413522GO:0042166
GeneOntologyMolecularFunctionregulatory RNA binding

AGO2 AGO4 AGO3

5.65e-0462523GO:0061980
GeneOntologyMolecularFunctionchloride channel regulator activity

CHRFAM7A CHRNA7

6.83e-0415522GO:0017081
GeneOntologyMolecularFunctionadenylate cyclase binding

CHRFAM7A CHRNA7

7.80e-0416522GO:0008179
GeneOntologyMolecularFunctionacetylcholine-gated monoatomic cation-selective channel activity

CHRFAM7A CHRNA7

8.82e-0417522GO:0022848
GeneOntologyMolecularFunctiontoxic substance binding

CHRFAM7A CHRNA7

9.91e-0418522GO:0015643
GeneOntologyMolecularFunctiondouble-stranded RNA binding

AGO2 AGO4 AGO3

1.10e-0378523GO:0003725
GeneOntologyMolecularFunctionRNA endonuclease activity

AGO2 AGO4 AGO3

1.15e-0379523GO:0004521
GeneOntologyMolecularFunctionextracellular matrix structural constituent

COL4A4 COL13A1 EMID1 MUC5AC

1.45e-03188524GO:0005201
GeneOntologyMolecularFunctionacetylcholine receptor activity

CHRFAM7A CHRNA7

1.62e-0323522GO:0015464
GeneOntologyMolecularFunctionsingle-stranded RNA binding

AGO2 AGO4 AGO3

3.03e-03111523GO:0003727
GeneOntologyBiologicalProcesssiRNA-mediated post-transcriptional gene silencing

AGO2 AGO4 AGO3

4.72e-084483GO:0140766
GeneOntologyBiologicalProcesssiRNA-mediated gene silencing by mRNA destabilization

AGO2 AGO4 AGO3

4.72e-084483GO:0090625
GeneOntologyBiologicalProcessRNA secondary structure unwinding

AGO2 AGO4 AGO3

9.84e-079483GO:0010501
GeneOntologyBiologicalProcessRISC complex assembly

AGO2 AGO4 AGO3

1.40e-0610483GO:0070922
GeneOntologyBiologicalProcesspositive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure

CHRFAM7A CHRNA7

5.30e-062482GO:0001988
GeneOntologyBiologicalProcesspre-miRNA processing

AGO2 AGO4 AGO3

7.86e-0617483GO:0031054
GeneOntologyBiologicalProcessbaroreceptor response to decreased systemic arterial blood pressure

CHRFAM7A CHRNA7

1.59e-053482GO:0001982
GeneOntologyBiologicalProcesspositive regulation of neuron migration

FLNA ZNF609 NIPBL

2.62e-0525483GO:2001224
GeneOntologyBiologicalProcessgeneration of ovulation cycle rhythm

CHRFAM7A CHRNA7

3.17e-054482GO:0060112
GeneOntologyBiologicalProcesssensory processing

CHRFAM7A CHRNA7

5.28e-055482GO:0050893
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback

CHRFAM7A CHRNA7

7.91e-056482GO:0001978
GeneOntologyBiologicalProcesspositive regulation of amide metabolic process

ZNF750 CHRFAM7A CHRNA7

8.69e-0537483GO:0034250
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure by baroreceptor feedback

CHRFAM7A CHRNA7

1.47e-048482GO:0003025
GeneOntologyBiologicalProcesspositive regulation of CoA-transferase activity

CHRFAM7A CHRNA7

1.89e-049482GO:1905920
GeneOntologyBiologicalProcessmiRNA processing

AGO2 AGO4 AGO3

1.90e-0448483GO:0035196
GeneOntologyBiologicalProcessresponse to cold

VGF CHRFAM7A CHRNA7

2.41e-0452483GO:0009409
GeneOntologyBiologicalProcessregulation of CoA-transferase activity

CHRFAM7A CHRNA7

2.88e-0411482GO:1905918
GeneOntologyBiologicalProcessbehavioral response to nicotine

CHRFAM7A CHRNA7

2.88e-0411482GO:0035095
GeneOntologyBiologicalProcessmRNA transcription

FLNA IRF3 TAF2

3.17e-0457483GO:0009299
GeneOntologyBiologicalProcessregulation of synapse structural plasticity

CHRFAM7A CHRNA7

3.45e-0412482GO:0051823
GeneOntologyBiologicalProcessregulation of neuron migration

FLNA ZNF609 NIPBL

4.06e-0462483GO:2001222
GeneOntologyBiologicalProcessregulation of synaptic transmission, dopaminergic

CHRFAM7A CHRNA7

4.07e-0413482GO:0032225
GeneOntologyBiologicalProcessmitotic spindle organization

FLNA GOLGA8B TACC2 DYNC1H1

4.18e-04151484GO:0007052
GeneOntologyBiologicalProcessneuronal action potential

ANK3 CHRFAM7A CHRNA7

4.26e-0463483GO:0019228
GeneOntologyBiologicalProcessdendrite arborization

CHRFAM7A CHRNA7

5.46e-0415482GO:0140059
GeneOntologyBiologicalProcessregulatory ncRNA processing

AGO2 AGO4 AGO3

6.83e-0474483GO:0070918
GeneOntologyBiologicalProcessbehavioral response to ethanol

CHRFAM7A CHRNA7

7.05e-0417482GO:0048149
GeneOntologyCellularComponentRISC-loading complex

AGO2 AGO4 AGO3

1.62e-0610513GO:0070578
GeneOntologyCellularComponentspine apparatus membrane

CHRFAM7A CHRNA7

1.75e-053512GO:0098897
GeneOntologyCellularComponentpostsynapse

FZD9 USP6 FLNA AGO2 COL13A1 ANK3 GAP43 PRRT2 CHRFAM7A CHRNA7 SLC12A5

2.74e-0510185111GO:0098794
GeneOntologyCellularComponentendoribonuclease complex

AGO2 AGO4 AGO3

1.00e-0437513GO:1902555
GeneOntologyCellularComponentsomatodendritic compartment

VGF FLNA AGO2 ANK3 GAP43 GOLGA8B PRRT2 CHRFAM7A DYNC1H1 CHRNA7 SLC12A5

1.49e-0412285111GO:0036477
GeneOntologyCellularComponentendonuclease complex

AGO2 AGO4 AGO3

1.58e-0443513GO:1905348
GeneOntologyCellularComponentpostsynaptic specialization

USP6 ANK3 GAP43 PRRT2 CHRFAM7A CHRNA7 SLC12A5

2.07e-04503517GO:0099572
GeneOntologyCellularComponentspine apparatus

CHRFAM7A CHRNA7

2.08e-049512GO:0097444
GeneOntologyCellularComponentpostsynaptic membrane

COL13A1 ANK3 PRRT2 CHRFAM7A CHRNA7 SLC12A5

4.39e-04405516GO:0045211
GeneOntologyCellularComponentdendritic shaft

FLNA CHRFAM7A CHRNA7

7.85e-0474513GO:0043198
GeneOntologyCellularComponentneuronal cell body

VGF FLNA GAP43 GOLGA8B CHRFAM7A DYNC1H1 CHRNA7 SLC12A5

8.70e-04835518GO:0043025
GeneOntologyCellularComponentacetylcholine-gated channel complex

CHRFAM7A CHRNA7

8.71e-0418512GO:0005892
GeneOntologyCellularComponentasymmetric synapse

USP6 ANK3 GAP43 PRRT2 CHRFAM7A CHRNA7

1.03e-03477516GO:0032279
GeneOntologyCellularComponentdendrite

FLNA AGO2 ANK3 GAP43 PRRT2 CHRFAM7A CHRNA7 SLC12A5

1.04e-03858518GO:0030425
GeneOntologyCellularComponentdendritic tree

FLNA AGO2 ANK3 GAP43 PRRT2 CHRFAM7A CHRNA7 SLC12A5

1.05e-03860518GO:0097447
GeneOntologyCellularComponentneuron projection membrane

CHRFAM7A CHRNA7 SLC12A5

1.06e-0382513GO:0032589
GeneOntologyCellularComponentglycinergic synapse

CHRFAM7A CHRNA7

1.08e-0320512GO:0098690
GeneOntologyCellularComponentfilopodium membrane

FZD9 GAP43

1.19e-0321512GO:0031527
GeneOntologyCellularComponentaxolemma

CHRFAM7A CHRNA7

1.19e-0321512GO:0030673
GeneOntologyCellularComponentcollagen trimer

COL4A4 COL13A1 EMID1

1.30e-0388513GO:0005581
GeneOntologyCellularComponentcholinergic synapse

CHRFAM7A CHRNA7

1.31e-0322512GO:0098981
GeneOntologyCellularComponentcostamere

ANK3 AHNAK

1.31e-0322512GO:0043034
GeneOntologyCellularComponentmain axon

ANK3 CHRFAM7A CHRNA7

1.34e-0389513GO:0044304
GeneOntologyCellularComponentpostsynaptic specialization membrane

PRRT2 CHRFAM7A CHRNA7 SLC12A5

1.46e-03201514GO:0099634
GeneOntologyCellularComponentneuron to neuron synapse

USP6 ANK3 GAP43 PRRT2 CHRFAM7A CHRNA7

1.65e-03523516GO:0098984
GeneOntologyCellularComponentcell body

VGF FLNA GAP43 GOLGA8B CHRFAM7A DYNC1H1 CHRNA7 SLC12A5

1.72e-03929518GO:0044297
GeneOntologyCellularComponentP-body

AGO2 AGO4 AGO3

1.98e-03102513GO:0000932
GeneOntologyCellularComponentsynaptic membrane

COL13A1 ANK3 PRRT2 CHRFAM7A CHRNA7 SLC12A5

2.85e-03583516GO:0097060
GeneOntologyCellularComponentgrowth cone

FLNA GAP43 CHRFAM7A CHRNA7

2.99e-03245514GO:0030426
GeneOntologyCellularComponentsite of polarized growth

FLNA GAP43 CHRFAM7A CHRNA7

3.35e-03253514GO:0030427
GeneOntologyCellularComponentfilopodium

FZD9 GAP43 DYNC1H1

3.37e-03123513GO:0030175
GeneOntologyCellularComponentcell projection membrane

FZD9 GAP43 CHRFAM7A CHRNA7 SLC12A5

3.92e-03431515GO:0031253
GeneOntologyCellularComponentdistal axon

FLNA GAP43 PRRT2 CHRFAM7A CHRNA7

4.08e-03435515GO:0150034
GeneOntologyCellularComponentcytoplasmic ribonucleoprotein granule

AGO2 AGO4 AGO3 RBM20

4.17e-03269514GO:0036464
GeneOntologyCellularComponentribonucleoprotein granule

AGO2 AGO4 AGO3 RBM20

5.24e-03287514GO:0035770
GeneOntologyCellularComponentaxon

FLNA ANK3 GAP43 PRRT2 CHRFAM7A DYNC1H1 CHRNA7

5.63e-03891517GO:0030424
GeneOntologyCellularComponentendoplasmic reticulum lumen

VGF COL4A4 SUMF2 COL13A1

8.69e-03332514GO:0005788
MousePhenoairway basal cell hyperplasia

CHRFAM7A CHRNA7

9.24e-062432MP:0011115
MousePhenoabnormal airway basal cell differentiation

CHRFAM7A CHRNA7

9.24e-062432MP:0011114
MousePhenoabnormal airway basal cell morphology

CHRFAM7A CHRNA7

9.24e-062432MP:0011113
MousePhenoabnormal nicotine-mediated receptor currents

CHRFAM7A CHRNA7

5.52e-054432MP:0009475
MousePhenoabnormal synapse morphology

COL13A1 PRRT2 CHRFAM7A DYNC1H1 CHRNA7 SLC12A5

5.88e-05224436MP:0009538
MousePhenoabnormal seizure response to pharmacological agent

FZD9 PRRT2 CHRFAM7A CHRNA7 SLC12A5

8.38e-05147435MP:0000950
MousePhenofailure of neuromuscular synapse presynaptic differentiation

CHRFAM7A CHRNA7

1.38e-046432MP:0001054
MousePhenoabnormal somatosensory cortex morphology

GAP43 CHRFAM7A CHRNA7

1.39e-0433433MP:0000859
MousePhenoabnormal spatial learning

VGF FZD9 KMT2D CHRFAM7A CHRNA7 SLC12A5

1.85e-04276436MP:0001463
MousePhenoabnormal parietal lobe morphology

GAP43 CHRFAM7A CHRNA7

1.96e-0437433MP:0000794
MousePhenoabnormal brain interneuron morphology

CHRFAM7A CHRNA7 SLC12A5

1.96e-0437433MP:0004101
MousePhenoabnormal neuromuscular synapse morphology

COL13A1 CHRFAM7A DYNC1H1 CHRNA7

2.02e-0495434MP:0001053
MousePhenoabnormal somatic motor system morphology

COL13A1 CHRFAM7A DYNC1H1 CHRNA7

2.27e-0498434MP:0001051
MousePhenoprolonged estrous cycle

VGF CHRFAM7A CHRNA7

2.29e-0439433MP:0009006
MousePhenoabnormal GABAergic neuron physiology

CHRFAM7A CHRNA7

2.56e-048432MP:0011987
MousePhenoabnormal behavioral response to xenobiotic

FZD9 PRRT2 CHRFAM7A NIPBL CHRNA7 SLC12A5

3.40e-04309436MP:0009745
MousePhenoabnormal seizure response to inducing agent

FZD9 PRRT2 CHRFAM7A CHRNA7 SLC12A5

3.61e-04201435MP:0009357
MousePhenoabnormal cerebral hemisphere morphology

FZD9 KMT2D GAP43 PRRT2 CHRFAM7A NIPBL DYNC1H1 CHRNA7

4.16e-04599438MP:0008540
MousePhenoabnormal cell differentiation

FZD9 ZNF750 GAP43 MYOG ZBTB40 CHRFAM7A NIPBL DYNC1H1 CHRNA7

5.84e-04795439MP:0005076
MousePhenoimpaired spatial working memory

CHRFAM7A CHRNA7

5.98e-0412432MP:0014370
MousePhenodecreased erythroblast number

CHRFAM7A CHRNA7

5.98e-0412432MP:0011179
MousePhenotremors

VGF COL13A1 ANK3 CHRFAM7A DYNC1H1 CHRNA7

6.88e-04353436MP:0000745
MousePhenoseizures

FZD9 ANK3 PRRT2 CHRFAM7A CHRNA7 SLC12A5

7.63e-04360436MP:0002064
DomainArgonaute_N

AGO2 AGO4 AGO3

8.13e-084523IPR032474
DomainArgonaute_Mid_dom

AGO2 AGO4 AGO3

8.13e-084523IPR032473
DomainArgoL2

AGO2 AGO4 AGO3

8.13e-084523IPR032472
DomainArgoN

AGO2 AGO4 AGO3

8.13e-084523PF16486
DomainArgoMid

AGO2 AGO4 AGO3

8.13e-084523PF16487
DomainArgoL2

AGO2 AGO4 AGO3

8.13e-084523PF16488
DomainDUF1785

AGO2 AGO4 AGO3

2.03e-075523SM01163
DomainArgoL1

AGO2 AGO4 AGO3

4.05e-076523PF08699
DomainArgoL1

AGO2 AGO4 AGO3

4.05e-076523IPR014811
DomainPIWI

AGO2 AGO4 AGO3

1.13e-068523PS50822
DomainPiwi

AGO2 AGO4 AGO3

1.13e-068523IPR003165
DomainPiwi

AGO2 AGO4 AGO3

1.13e-068523PF02171
DomainPiwi

AGO2 AGO4 AGO3

1.13e-068523SM00950
DomainPAZ

AGO2 AGO4 AGO3

1.69e-069523PS50821
DomainPAZ_dom

AGO2 AGO4 AGO3

1.69e-069523IPR003100
DomainPAZ

AGO2 AGO4 AGO3

1.69e-069523PF02170
DomainPAZ

AGO2 AGO4 AGO3

1.69e-069523SM00949
Domain-

AGO2 AGO4 AGO3

3.03e-04475233.30.420.10
DomainRNaseH-like_dom

AGO2 AGO4 AGO3

9.37e-0469523IPR012337
DomainCollagen

COL4A4 COL13A1 EMID1

1.71e-0385523PF01391
DomainCollagen

COL4A4 COL13A1 EMID1

1.71e-0385523IPR008160
DomainAcetylcholine_rcpt_TM

CHRFAM7A CHRNA7

1.85e-0323522IPR027361
Domain-

CHRFAM7A CHRNA7

1.85e-03235221.20.120.370
DomainC2H2_Znf_fam

ZSCAN5B ZSCAN18

2.02e-0324522IPR027775
DomainZnf_C2H2-like

ZNF750 ZSCAN5B ZNF469 ZNF609 ZSCAN18 ZBTB40 GPATCH8

6.26e-03796527IPR015880
DomainZnf_C2H2

ZNF750 ZSCAN5B ZNF469 ZNF609 ZSCAN18 ZBTB40 GPATCH8

6.65e-03805527IPR007087
DomainZnF_C2H2

ZNF750 ZSCAN5B ZNF469 ZNF609 ZSCAN18 ZBTB40 GPATCH8

6.78e-03808527SM00355
DomainNeurotransmitter_ion_chnl_CS

CHRFAM7A CHRNA7

6.97e-0345522IPR018000
DomainNeur_chan_memb

CHRFAM7A CHRNA7

7.28e-0346522PF02932
DomainNeur_chan_LBD

CHRFAM7A CHRNA7

7.59e-0347522PF02931
DomainNeur_channel

CHRFAM7A CHRNA7

7.59e-0347522IPR006201
DomainNeur_chan_lig-bd

CHRFAM7A CHRNA7

7.59e-0347522IPR006202
DomainNEUROTR_ION_CHANNEL

CHRFAM7A CHRNA7

7.59e-0347522PS00236
DomainNeurotrans-gated_channel_TM

CHRFAM7A CHRNA7

7.59e-0347522IPR006029
Domain-

CHRFAM7A CHRNA7

7.59e-03475222.70.170.10
DomainSCAN

ZSCAN5B ZSCAN18

1.06e-0256522SM00431
DomainSCAN_BOX

ZSCAN5B ZSCAN18

1.14e-0258522PS50804
DomainSCAN

ZSCAN5B ZSCAN18

1.14e-0258522PF02023
DomainSCAN_dom

ZSCAN5B ZSCAN18

1.14e-0258522IPR003309
DomainRetrov_capsid_C

ZSCAN5B ZSCAN18

1.18e-0259522IPR008916
PathwayBIOCARTA_DICER_PATHWAY

AGO2 AGO4 AGO3

1.06e-075323M22079
PathwayREACTOME_MICRORNA_MIRNA_BIOGENESIS

AGO2 AGO4 AGO3

2.12e-076323MM14818
PathwayREACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS

AGO2 AGO4 AGO3

2.12e-076323MM15083
PathwayREACTOME_POST_TRANSCRIPTIONAL_SILENCING_BY_SMALL_RNAS

AGO2 AGO4 AGO3

3.70e-077323M46421
PathwayREACTOME_TGFBR3_EXPRESSION

AGO2 AGO4 AGO3 MYOG

4.31e-0728324M48253
PathwayREACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS

AGO2 AGO4 AGO3

5.90e-078323MM15082
PathwayREACTOME_SMALL_INTERFERING_RNA_SIRNA_BIOGENESIS

AGO2 AGO4 AGO3

8.84e-079323M27340
PathwayREACTOME_REGULATION_OF_PTEN_MRNA_TRANSLATION

AGO2 AGO4 AGO3

8.84e-079323M27810
PathwayREACTOME_REGULATION_OF_NPAS4_MRNA_TRANSLATION

AGO2 AGO4 AGO3

8.84e-079323M46436
PathwayREACTOME_REGULATION_OF_CDH11_MRNA_TRANSLATION_BY_MICRORNAS

AGO2 AGO4 AGO3

1.26e-0610323M48013
PathwayREACTOME_REGULATION_OF_NPAS4_GENE_EXPRESSION

AGO2 AGO4 AGO3

2.99e-0613323M46434
PathwayREACTOME_SIGNALING_BY_TGFBR3

AGO2 AGO4 AGO3 MYOG

4.31e-0649324M48250
PathwayREACTOME_REGULATION_OF_RUNX1_EXPRESSION_AND_ACTIVITY

AGO2 AGO4 AGO3

7.07e-0617323M27788
PathwayREACTOME_REGULATION_OF_MITF_M_DEPENDENT_GENES_INVOLVED_IN_APOPTOSIS

AGO2 AGO4 AGO3

1.00e-0519323M48238
PathwayREACTOME_MICRORNA_MIRNA_BIOGENESIS

AGO2 AGO4 AGO3

2.36e-0525323M712
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

AGO2 AGO4 AGO3 MYOG PPP1R15A

2.87e-05161325M27871
PathwayREACTOME_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION

AGO2 AGO4 AGO3

5.04e-0532323M48012
PathwayREACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY

AGO2 AGO4 AGO3

5.04e-0532323M27900
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4

AGO2 AGO4 AGO3

6.06e-0534323M46422
PathwayREACTOME_NUCLEAR_EVENTS_STIMULATED_BY_ALK_SIGNALING_IN_CANCER

AGO2 AGO4 AGO3

6.62e-0535323M42525
PathwayREACTOME_NR1H3_NR1H2_REGULATE_GENE_EXPRESSION_LINKED_TO_CHOLESTEROL_TRANSPORT_AND_EFFLUX

AGO2 AGO4 AGO3

7.83e-0537323M29790
PathwayREACTOME_CELL_JUNCTION_ORGANIZATION

FLNA AGO2 AGO4 AGO3

1.35e-04117324M19248
PathwayREACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING

AGO2 AGO4 AGO3

1.61e-0447323M29777
PathwayREACTOME_GENE_SILENCING_BY_RNA

AGO2 AGO4 AGO3

1.82e-0449323MM14837
PathwayREACTOME_ADHERENS_JUNCTIONS_INTERACTIONS

AGO2 AGO4 AGO3

3.01e-0458323M11980
PathwayREACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS

CHRFAM7A CHRNA7

3.25e-0412322MM15312
PathwayREACTOME_CA2_PATHWAY

AGO2 AGO4 AGO3

3.67e-0462323M27321
PathwayREACTOME_ZBP1_DAI_MEDIATED_INDUCTION_OF_TYPE_I_IFNS

NFKBIB IRF3

3.83e-0413322MM14616
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_MECP2

AGO2 AGO4 AGO3

3.85e-0463323M27862
PathwayREACTOME_CELL_CELL_COMMUNICATION

FLNA AGO2 AGO4 AGO3

3.98e-04155324M522
PathwayREACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS

CHRFAM7A CHRNA7

5.15e-0415322MM14704
PathwayREACTOME_TP53_REGULATES_METABOLIC_GENES

AGO2 AGO4 AGO3

8.94e-0484323M27495
PathwayREACTOME_ZBP1_DAI_MEDIATED_INDUCTION_OF_TYPE_I_IFNS

NFKBIB IRF3

1.02e-0321322M26978
PathwayREACTOME_CELL_CELL_JUNCTION_ORGANIZATION

AGO2 AGO4 AGO3

1.09e-0390323M820
PathwayREACTOME_MAPK6_MAPK4_SIGNALING

AGO2 AGO4 AGO3

1.20e-0393323M27572
PathwayREACTOME_SIGNALING_BY_ALK_IN_CANCER

AGO2 AGO4 AGO3

1.20e-0393323M42521
PathwayWP_15Q133_COPY_NUMBER_VARIATION_SYNDROME

CHRFAM7A CHRNA7

1.23e-0323322M39883
PathwayREACTOME_MITF_M_DEPENDENT_GENE_EXPRESSION

AGO2 AGO4 AGO3

1.28e-0395323M48268
PathwayREACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION

KMT2D AGO4 AGO3

1.32e-0396323M27792
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1

KMT2D AGO2 AGO4 AGO3

1.93e-03237324M27786
PathwayREACTOME_CYTOSOLIC_SENSORS_OF_PATHOGEN_ASSOCIATED_DNA

NFKBIB IRF3

2.37e-0332322MM14707
PathwayREACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING

AGO2 AGO4 AGO3

2.43e-03119323M607
PathwayREACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA

NFKBIB IRF3

2.52e-0333322MM14666
PathwayREACTOME_ONCOGENE_INDUCED_SENESCENCE

AGO4 AGO3

2.83e-0335322M27190
PathwayREACTOME_MITF_M_REGULATED_MELANOCYTE_DEVELOPMENT

AGO2 AGO4 AGO3

3.62e-03137323M48232
PathwayREACTOME_PTEN_REGULATION

AGO2 AGO4 AGO3

3.77e-03139323M27646
PathwayREACTOME_GENE_SILENCING_BY_RNA

AGO2 AGO4 AGO3

3.77e-03139323M715
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_VENTX

AGO4 AGO3

3.87e-0341322M29748
PathwayREACTOME_COLLAGEN_CHAIN_TRIMERIZATION

COL4A4 COL13A1

3.87e-0341322MM15538
PathwayREACTOME_BETA_CATENIN_INDEPENDENT_WNT_SIGNALING

AGO2 AGO4 AGO3

4.33e-03146323M27288
PathwayREACTOME_COLLAGEN_CHAIN_TRIMERIZATION

COL4A4 COL13A1

4.45e-0344322M27812
Pubmed

Human transcription factor protein interaction networks.

ZNF609 KMT2D IRS4 AGO2 AGO3 NFKBIB ZSCAN18 ZBTB40 IRF3 TAF2 GPATCH8 MIDEAS NIPBL RBM20 DYNC1H1 NPAT

2.14e-101429531635140242
Pubmed

Sequential interplay of nicotinic and GABAergic signaling guides neuronal development.

CHRFAM7A CHRNA7 SLC12A5

3.34e-09353317158331
Pubmed

Molecular dissection of human Argonaute proteins by DNA shuffling.

AGO2 AGO4 AGO3

1.34e-08453323748378
Pubmed

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.

AGO2 AGO4 AGO3

1.34e-08453315260970
Pubmed

Argonaute proteins: potential biomarkers for human colon cancer.

AGO2 AGO4 AGO3

1.34e-08453320146808
Pubmed

Slicing-independent RISC activation requires the argonaute PAZ domain.

AGO2 AGO4 AGO3

1.34e-08453322795694
Pubmed

ATP-dependent human RISC assembly pathways.

AGO2 AGO4 AGO3

1.34e-08453319966796
Pubmed

Importance of translation and nonnucleolytic ago proteins for on-target RNA interference.

AGO2 AGO4 AGO3

1.34e-08453318771919
Pubmed

Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors.

AGO2 AGO4 AGO3

3.33e-08553312526743
Pubmed

Differential expression of Dicer and Argonaute genes during the differentiation of human neuroblastoma cells.

AGO2 AGO4 AGO3

3.33e-08553319393748
Pubmed

Differential expression of components of the microRNA machinery during mouse organogenesis.

AGO2 AGO4 AGO3

3.33e-08553316036130
Pubmed

The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis.

AGO2 AGO4 AGO3

3.33e-08553312414724
Pubmed

The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing.

AGO2 AGO4 AGO3

3.33e-08553319324964
Pubmed

Functional dissection of the human TNRC6 (GW182-related) family of proteins.

AGO2 AGO4 AGO3

1.16e-07753319470757
Pubmed

Genome-wide identification of microRNA targets reveals positive regulation of the Hippo pathway by miR-122 during liver development.

AGO2 AGO4 AGO3

1.16e-07753334907157
Pubmed

Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps.

AGO2 AGO4 AGO3

1.16e-07753319536157
Pubmed

The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.

AGO2 AGO4 AGO3

1.16e-07753319383768
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

FLNA KMT2D IRS4 AGO2 ANK3 AHNAK TAF2 MIDEAS DYNC1H1

1.36e-0754953938280479
Pubmed

Mili interacts with tudor domain-containing protein 1 in regulating spermatogenesis.

AGO2 AGO4 AGO3

1.86e-07853319345100
Pubmed

Suppression of microRNA Activity in Kidney Collecting Ducts Induces Partial Loss of Epithelial Phenotype and Renal Fibrosis.

AGO2 AGO4 AGO3

1.86e-07853329021386
Pubmed

Identification of eight members of the Argonaute family in the human genome.

AGO2 AGO4 AGO3

2.79e-07953312906857
Pubmed

Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs.

AGO2 AGO4 AGO3

1.85e-061653320102707
Pubmed

Enhancing cognitive function in chronic TBI: The Role of α7 nicotinic acetylcholine receptor modulation.

CHRFAM7A CHRNA7

2.28e-06253238070724
Pubmed

Inflammatory cytokines decrease the expression of nicotinic acetylcholine receptor during the cell maturation.

CHRFAM7A CHRNA7

2.28e-06253219626424
Pubmed

Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene.

CHRFAM7A CHRNA7

2.28e-06253217012698
Pubmed

Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke.

CHRFAM7A CHRNA7

2.28e-06253226451017
Pubmed

Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology.

CHRFAM7A CHRNA7

2.28e-06253234453977
Pubmed

Perinatal hypoxia-ischemia reduces α 7 nicotinic receptor expression and selective α 7 nicotinic receptor stimulation suppresses inflammation and promotes microglial Mox phenotype.

CHRFAM7A CHRNA7

2.28e-06253224757672
Pubmed

Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

CHRFAM7A CHRNA7

2.28e-06253226999808
Pubmed

Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.

CHRFAM7A CHRNA7

2.28e-06253227129924
Pubmed

Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice.

CHRFAM7A CHRNA7

2.28e-06253217291692
Pubmed

Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice.

CHRFAM7A CHRNA7

2.28e-06253223521765
Pubmed

Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.

CHRFAM7A CHRNA7

2.28e-06253228258105
Pubmed

The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation.

CHRFAM7A CHRNA7

2.28e-06253219344760
Pubmed

Loss of α7nAChR enhances endothelial-to-mesenchymal transition after myocardial infarction via NF-κB activation.

CHRFAM7A CHRNA7

2.28e-06253235926661
Pubmed

The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice.

CHRFAM7A CHRNA7

2.28e-06253217640819
Pubmed

Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure.

CHRFAM7A CHRNA7

2.28e-06253223431157
Pubmed

Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors.

CHRFAM7A CHRNA7

2.28e-06253229114104
Pubmed

Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.

CHRFAM7A CHRNA7

2.28e-06253233995108
Pubmed

E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation.

CHRFAM7A CHRNA7

2.28e-06253232552811
Pubmed

Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits.

CHRFAM7A CHRNA7

2.28e-06253224836856
Pubmed

Modulation of the MAPKs pathways affects Aβ-induced cognitive deficits in Alzheimer's disease via activation of α7nAChR.

CHRFAM7A CHRNA7

2.28e-06253231904546
Pubmed

Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction.

CHRFAM7A CHRNA7

2.28e-06253215948184
Pubmed

Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.

CHRFAM7A CHRNA7

2.28e-06253235678315
Pubmed

Age-Associated Tooth Loss and Oral Microbial Dysbiosis in a Mouse Genetic Model of Chronic Nicotine Exposure.

CHRFAM7A CHRNA7

2.28e-06253233117372
Pubmed

Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis.

CHRFAM7A CHRNA7

2.28e-06253212628457
Pubmed

Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress.

CHRFAM7A CHRNA7

2.28e-06253225157794
Pubmed

Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.

CHRFAM7A CHRNA7

2.28e-06253219615981
Pubmed

Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-out mice via the spleen-gut-brain axis.

CHRFAM7A CHRNA7

2.28e-06253238944290
Pubmed

Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice.

CHRFAM7A CHRNA7

2.28e-06253228243714
Pubmed

Mesenchymal Stem Cells or Interleukin-6 Improve Episodic Memory of Mice Lacking α7 Nicotinic Acetylcholine Receptors.

CHRFAM7A CHRNA7

2.28e-06253231202708
Pubmed

Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors.

CHRFAM7A CHRNA7

2.28e-06253222246862
Pubmed

Stimulation of the α7 nicotinic acetylcholine receptor protects against sepsis by inhibiting Toll-like receptor via phosphoinositide 3-kinase activation.

CHRFAM7A CHRNA7

2.28e-06253224298024
Pubmed

Lung eosinophilia induced by house dust mites or ovalbumin is modulated by nicotinic receptor α7 and inhibited by cigarette smoke.

CHRFAM7A CHRNA7

2.28e-06253229975102
Pubmed

α7-nAChR Knockout Mice Decreases Biliary Hyperplasia and Liver Fibrosis in Cholestatic Bile Duct-Ligated Mice.

CHRFAM7A CHRNA7

2.28e-06253229580318
Pubmed

Alpha-7 Nicotinic Receptor Dampens Murine Osteoblastic Response to Inflammation and Age-Related Osteoarthritis.

CHRFAM7A CHRNA7

2.28e-06253235479080
Pubmed

[Activation of α7 nAChR improves white fat homeostasis and promotes beige adipogenesis and thermogenesis in obese mice].

CHRFAM7A CHRNA7

2.28e-06253238597441
Pubmed

Activation of Nicotinic Acetylcholine Receptors Decreases Apoptosis in Human and Female Murine Pancreatic Islets.

CHRFAM7A CHRNA7

2.28e-06253227471776
Pubmed

Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury.

CHRFAM7A CHRNA7

2.28e-06253222688057
Pubmed

α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice.

CHRFAM7A CHRNA7

2.28e-06253222820264
Pubmed

Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis.

CHRFAM7A CHRNA7

2.28e-06253233953172
Pubmed

Different Effects of Nicotine and N-Stearoyl-ethanolamine on Episodic Memory and Brain Mitochondria of α7 Nicotinic Acetylcholine Receptor Knockout Mice.

CHRFAM7A CHRNA7

2.28e-06253232028688
Pubmed

Genetic variation in CHRNA7 and CHRFAM7A is associated with nicotine dependence and response to varenicline treatment.

CHRFAM7A CHRNA7

2.28e-06253230089821
Pubmed

Nicotinic acetylcholine receptor activation reduces skeletal muscle inflammation of mdx mice.

CHRFAM7A CHRNA7

2.28e-06253220615555
Pubmed

Nicotine physical dependence in the mouse: involvement of the alpha7 nicotinic receptor subtype.

CHRFAM7A CHRNA7

2.28e-06253215896732
Pubmed

Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice.

CHRFAM7A CHRNA7

2.28e-06253230429582
Pubmed

A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neurons.

CHRFAM7A CHRNA7

2.28e-06253221501254
Pubmed

α7-cholinergic receptor mediates vagal induction of splenic norepinephrine.

CHRFAM7A CHRNA7

2.28e-06253221339364
Pubmed

Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors.

CHRFAM7A CHRNA7

2.28e-06253221368056
Pubmed

Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice.

CHRFAM7A CHRNA7

2.28e-06253224289814
Pubmed

Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury.

CHRFAM7A CHRNA7

2.28e-06253219949071
Pubmed

Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice.

CHRFAM7A CHRNA7

2.28e-0625321400473
Pubmed

Reversible inhibition of GABAA receptors by alpha7-containing nicotinic receptors on the vertebrate postsynaptic neurons.

CHRFAM7A CHRNA7

2.28e-06253217204496
Pubmed

Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood-Brain Barrier Permeability following Experimental Traumatic Brain Injury.

CHRFAM7A CHRNA7

2.28e-06253226937017
Pubmed

α7 nicotinic receptors play a role in regulation of cardiac hemodynamics.

CHRFAM7A CHRNA7

2.28e-06253237017608
Pubmed

Impaired hippocampal theta oscillations in the mice null alpha7 nicotinic acetylcholine receptors.

CHRFAM7A CHRNA7

2.28e-06253223795917
Pubmed

Diminished α7 nicotinic acetylcholine receptor (α7nAChR) rescues amyloid-β induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated mitochondrial oxidative stress.

CHRFAM7A CHRNA7

2.28e-06253236603528
Pubmed

Endogenous signaling through alpha7-containing nicotinic receptors promotes maturation and integration of adult-born neurons in the hippocampus.

CHRFAM7A CHRNA7

2.28e-06253220592195
Pubmed

Activation of α7nAChR Promotes Diabetic Wound Healing by Suppressing AGE-Induced TNF-α Production.

CHRFAM7A CHRNA7

2.28e-06253226650489
Pubmed

Increased sensitivity to nicotine-induced seizures in mice expressing the L250T alpha 7 nicotinic acetylcholine receptor mutation.

CHRFAM7A CHRNA7

2.28e-06253211854451
Pubmed

Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons.

CHRFAM7A CHRNA7

2.28e-06253222848433
Pubmed

Nicotine prevents synaptic impairment induced by amyloid-β oligomers through α7-nicotinic acetylcholine receptor activation.

CHRFAM7A CHRNA7

2.28e-06253223842742
Pubmed

Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors.

CHRFAM7A CHRNA7

2.28e-06253217292512
Pubmed

Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice.

CHRFAM7A CHRNA7

2.28e-06253216650968
Pubmed

Microglial cell response in α7 nicotinic acetylcholine receptor-deficient mice after systemic infection with Escherichia coli.

CHRFAM7A CHRNA7

2.28e-06253235413868
Pubmed

Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood-brain barrier disorders caused by microbial and non-microbial factors.

CHRFAM7A CHRNA7

2.28e-06253223637989
Pubmed

Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7).

CHRFAM7A CHRNA7

2.28e-0625329782083
Pubmed

Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice.

CHRFAM7A CHRNA7

2.28e-06253224462939
Pubmed

Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue.

CHRFAM7A CHRNA7

2.28e-06253229261717
Pubmed

Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous mice.

CHRFAM7A CHRNA7

2.28e-06253218199426
Pubmed

Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury.

CHRFAM7A CHRNA7

2.28e-06253222490926
Pubmed

Kynurenic acid blunts A1 astrocyte activation against neurodegeneration in HIV-associated neurocognitive disorders.

CHRFAM7A CHRNA7

2.28e-06253236997969
Pubmed

A phenotype for the alpha 7 nicotinic acetylcholine receptor null mutant.

CHRFAM7A CHRNA7

2.28e-06253215364017
Pubmed

Choline, an alpha7 nicotinic acetylcholine receptor agonist, alleviates hyperalgesia in a rat osteoarthritis model.

CHRFAM7A CHRNA7

2.28e-06253223769729
Pubmed

Mice deficient in CHRNA7, a subunit of the nicotinic acetylcholine receptor, produce sperm with impaired motility.

CHRFAM7A CHRNA7

2.28e-06253215944242
Pubmed

Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice.

CHRFAM7A CHRNA7

2.28e-06253223270857
Pubmed

Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation.

CHRFAM7A CHRNA7

2.28e-06253218077004
Pubmed

Smoking in adult attention-deficit/hyperactivity disorder: interaction between 15q13 nicotinic genes and Temperament Character Inventory scores.

CHRFAM7A CHRNA7

2.28e-06253219462340
Pubmed

Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory.

CHRFAM7A CHRNA7

2.28e-06253216923147
Pubmed

NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor.

CHRFAM7A CHRNA7

2.28e-06253211790782
InteractionTLE3 interactions

FLNA ZNF609 KMT2D ANK3 ZSCAN18 GPATCH8 MIDEAS NIPBL RBM20

3.79e-07376519int:TLE3
InteractionRNF41 interactions

FLNA IRS4 AHNAK IRF3 TACC2 NPAT

3.52e-06164516int:RNF41
InteractionFEV interactions

ZNF609 KMT2D TAF2 GPATCH8 MIDEAS NIPBL

1.20e-05203516int:FEV
InteractionTDRD1 interactions

AGO2 AGO4 AGO3

1.44e-0519513int:TDRD1
InteractionPHF21A interactions

FLNA KMT2D IRS4 AHNAK VPS53 RBM20 NPAT

2.37e-05343517int:PHF21A
InteractionRCOR1 interactions

ZNF750 FLNA KMT2D IRS4 AHNAK VPS53 RBM20 NPAT

3.11e-05494518int:RCOR1
InteractionALG13 interactions

ZNF609 KMT2D PAGE4 GPATCH8 RBM20

9.79e-05183515int:ALG13
InteractionKDM1A interactions

ZNF750 FLNA IL16 ZNF609 KMT2D IRS4 AHNAK VPS53 RBM20 NPAT

1.05e-049415110int:KDM1A
InteractionSP7 interactions

ZNF609 KMT2D GPATCH8 MIDEAS NIPBL RBM20

1.14e-04304516int:SP7
InteractionSMG7 interactions

ZNF609 KMT2D AGO2 ZSCAN18 GPATCH8 RBM20

1.48e-04319516int:SMG7
InteractionNUP43 interactions

FLNA ZNF609 KMT2D TAF2 GPATCH8 MIDEAS NIPBL NPAT

1.61e-04625518int:NUP43
InteractionEN1 interactions

ZNF609 KMT2D MIDEAS NIPBL

1.72e-04110514int:EN1
InteractionPAX8 interactions

ZNF609 KMT2D MIDEAS NIPBL

1.78e-04111514int:PAX8
Cytoband1p34

AGO4 AGO3

6.34e-04325321p34
Cytoband15q14

GOLGA8B CHRNA7

1.49e-034953215q14
GeneFamilyArgonaute/PIWI family

AGO2 AGO4 AGO3

3.08e-078333408
GeneFamilyCollagens

COL4A4 COL13A1

3.18e-0346332490
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD VGF GAP43 MYOG CHRFAM7A

3.43e-061945355bd0f739aa75f387cca7c3b2686493ee2d1ee968
ToppCellCOVID-19|World / Disease, condition lineage and cell class

FLNA AHNAK PPP1R15A NIPBL DYNC1H1

3.98e-062005357dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-3|TCGA-Brain / Sample_Type by Project: Shred V9

ZNF609 AGO4 AGO3 ZBTB40

2.03e-051355343351e8b9e417397c5fa9f856184ff24ce1a27242
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma|TCGA-Brain / Sample_Type by Project: Shred V9

AGO4 AGO3 AHNAK ZSCAN18

4.13e-05162534810881210e015c788814e4fe8d7a24c929cf2621
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW08-Neuronal|GW08 / Sample Type, Dataset, Time_group, and Cell type.

ANK3 GAP43 DYNC1H1

4.79e-055953374590437b1d9a2a8fe56d79b2e66803528b81298
ToppCelldroplet-Heart-HEART-1m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHD ANK3 GAP43 EMID1

5.34e-051735349dc7746a84f0e268a7c061e1bbcd5e31903034dc
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-leukocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL13A1 ANK3 GAP43 EMID1

5.58e-05175534f6e1d7297a4dbb38e1ab4f738d91f0e62abaee69
ToppCellfacs-Thymus-Epithelium-3m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AHNAK ZSCAN18 PPP1R15A MIDEAS

5.83e-051775340e9e44119653abfd270e602e5e477a15e774638f
ToppCellfacs-Thymus-Epithelium-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AHNAK ZSCAN18 PPP1R15A MIDEAS

5.83e-05177534c2b8a3a149d70f77612759dea34df9e43953c566
ToppCellfacs-Thymus-Epithelium-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AHNAK ZSCAN18 PPP1R15A MIDEAS

5.83e-05177534384f841aa7b2d05815af7885e481f5affc55d897
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANK3 AHNAK GOLGA8B PPP1R15A

6.09e-05179534b0585a8e596c3d8e434af943e65207fa5877600d
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD GAP43 CHRFAM7A SLC12A5

6.36e-051815347f99002a6411117cc2361334c7c9228e20c574b4
ToppCellControl-B_memory-0|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

COL4A4 ANK3 AHNAK PPP1R15A

7.07e-0518653480f6f25dbe3c5efe4bc350f5d2eb990c38aab338
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD VGF GAP43 CHRFAM7A

7.22e-05187534a748b3a59e398e0da019db3f16d38adb1960c29f
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD GAP43 MYOG CHRFAM7A

7.52e-051895343f5522be3e24dcdb6272f18cee2f239dfdeff9ad
ToppCellCOPD-Epithelial-ATI|Epithelial / Disease state, Lineage and Cell class

COL4A4 FLNA AHNAK GOLGA8B

7.52e-0518953414e8e57e4db336fbef005270647983b4edf407c0
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD GAP43 MYOG CHRFAM7A

7.99e-05192534d8f5df2c2a50e567f24ebecc8033ac97ba89d9c5
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_B|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD GAP43 MYOG CHRFAM7A

8.15e-051935349661ea0ee7273928c7de2a9f49e853595fa77699
ToppCellControl-B_memory-0|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

COL4A4 ANK3 AHNAK PPP1R15A

8.15e-05193534b8d64cc0abc4a3311e172e7e48a7de0f2188effb
ToppCellSmart-seq2-lymph_node_(Smart-seq2)|Smart-seq2 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

IL16 RCSD1 PPP1R15A MIDEAS

8.65e-051965343a8bd09a09c19df27c954d448f1bae945314c221
ToppCellnormal_Lung-Epithelial_cells-AT1|Epithelial_cells / Location, Cell class and cell subclass

COL4A4 FLNA AHNAK GOLGA8B

8.83e-051975347d19b93d6853828e2a036e37c4887edb1de4503c
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_A-Branch_A1_(iMN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD VGF GAP43 CHRFAM7A

9.00e-05198534328f1d5d8168e05edd301d3a0f2eb5c6cd1c67c8
ToppCellCOVID-19_Mild|World / Disease condition and Cell class

FLNA AHNAK PPP1R15A DYNC1H1

9.00e-0519853461ceb2245b6cb58e308b999a61d218c89dbc615e
ToppCelllymphoid-T_cell-Regulatory_T_cell|T_cell / Lineage, cell class and subclass

FLNA GAP43 AHNAK RCSD1

9.00e-051985346773c6043ef4a3d9e9700330b6386431ee66abdc
ToppCellB_cells-Activate_B_cells|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis

FLNA IL16 ANK3 AHNAK

9.00e-05198534a663082d7fbd6db11d3d3024bbb8ba00183e19f8
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Neuronal-Intermediate|6m / Sample Type, Dataset, Time_group, and Cell type.

SHD GOLGA8B PPP1R15A NIPBL

9.36e-052005347c261e39ac30b318511373ab7302aa53b8b81b9c
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Interneuron|5w / Sample Type, Dataset, Time_group, and Cell type.

VGF ANK3 GAP43 DYNC1H1

9.36e-05200534c7e33057466915d4e2b34f2062b22d9cdffa69dc
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal|5w / Sample Type, Dataset, Time_group, and Cell type.

VGF ANK3 GAP43 DYNC1H1

9.36e-052005349b5753726c17dda98d7384a60f26a5eaf4f6c4d6
ToppCell5'-GW_trimst-1.5-LargeIntestine-Neuronal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SHD VGF GAP43 CHRFAM7A

9.36e-0520053451d20543a9c9330c34c085d9290a1fc8b5bff0d4
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal-Intermediate|5w / Sample Type, Dataset, Time_group, and Cell type.

VGF ANK3 GAP43 PRRT2

9.36e-05200534c92e4fc0442404481fcac623d691dae6215b852d
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW08-Neuronal|GW08 / Sample Type, Dataset, Time_group, and Cell type.

ANK3 GAP43 DYNC1H1

1.19e-04805335c39136f5f855efbf61e1f5348ea97ea2130b241
DrugDyclonine hydrochloride [536-43-6]; Up 200; 12.2uM; HL60; HT_HG-U133A

VGF ZNF609 OGFR ZSCAN18 PPP1R15A SLC12A5

6.02e-061995262392_UP
DrugNSC750927

VGF ANK3 OGFR IRF3 PPP1R15A DYNC1H1

1.44e-05232526CID000003461
Druggemcitabine

VGF IL16 ANK3 IRF3 PPP1R15A DYNC1H1

3.39e-05270526ctd:C056507
Drugbifemelane

GAP43 CHRFAM7A CHRNA7

3.94e-0529523CID000002377
DrugStrophantine octahydrate [11018-89-6]; Up 200; 5.4uM; HL60; HT_HG-U133A

ZNF609 NFKBIB ZBTB40 PPP1R15A NIPBL

4.78e-051745251302_UP
DrugCamptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; PC3; HT_HG-U133A

HSPBAP1 ZBTB40 TACC2 NIPBL NPAT

5.62e-051805254541_DN
Drug0297417-0002B [362658-29-5]; Up 200; 10uM; MCF7; HT_HG-U133A

ZNF750 OGFR PPP1R15A MUC5AC SLC12A5

6.73e-051875256902_UP
Drugquinoxaline-2-carboxylic acid

FLNA GAP43 MYOG

7.61e-0536523CID000096695
DrugHexetidine [141-94-6]; Down 200; 11.8uM; MCF7; HT_HG-U133A

VGF ZNF609 OGFR NFKBIB NPAT

7.63e-051925253318_DN
DrugBenfluorex hydrochloride [23642-66-2]; Up 200; 10.4uM; PC3; HT_HG-U133A

ZNF609 KMT2D IRS4 PPP1R15A MUC5AC

8.01e-051945256727_UP
DrugAtovaquone [95233-18-4]; Up 200; 11uM; MCF7; HT_HG-U133A

FZD9 IL16 AGO4 MUC5AC VPS53

8.01e-051945254786_UP
DrugMonobenzone [103-16-2]; Up 200; 20uM; HL60; HT_HG-U133A

COL4A4 NFKBIB ZBTB40 PPP1R15A VPS53

8.21e-051955253054_UP
DrugCisapride [81098-60-4]; Down 200; 8.6uM; HL60; HT_HG-U133A

ZNF609 OGFR AHNAK EMID1 VPS53

8.41e-051965252443_DN
Drugrofecoxib; Down 200; 10uM; HL60; HG-U133A

ZNF609 KMT2D ANK3 ZBTB40 GPATCH8

8.61e-05197525371_DN
DrugCloxacillin sodium salt [642-78-4]; Down 200; 8.8uM; MCF7; HT_HG-U133A

VGF OGFR NFKBIB ZBTB40 RPUSD2

8.61e-051975257483_DN
DrugSR-95639A [115767-94-7]; Down 200; 10uM; MCF7; HT_HG-U133A

ZNF750 ANK3 OGFR NFKBIB PPP1R15A

8.61e-051975254977_DN
DrugGlycopyrrolate [596-51-0]; Up 200; 10uM; PC3; HT_HG-U133A

IL16 ZNF609 IRS4 OGFR VPS53

8.61e-051975253687_UP
DrugDihydroergocristine mesylate [24730-10-7]; Down 200; 5.6uM; MCF7; HT_HG-U133A

OGFR HSPBAP1 NFKBIB ZBTB40 NPAT

8.82e-051985257034_DN
DrugProstaglandin E1; Down 200; 10uM; MCF7; HT_HG-U133A

ZNF609 SLC38A10 EMID1 PPP1R15A SLC12A5

8.82e-051985256576_DN
DrugCefoxitin sodium salt [33564-30-6]; Down 200; 8.8uM; PC3; HT_HG-U133A

ZNF609 OGFR ZBTB40 TACC2 NIPBL

9.03e-051995257148_DN
DrugDisopyramide [3737-09-5]; Up 200; 11.8uM; MCF7; HT_HG-U133A

ZNF609 SLC38A10 EMID1 NFKBIB SLC12A5

9.03e-051995257439_UP
DiseasePhyllodes Tumor

FLNA KMT2D

3.04e-055522C0010701
DiseaseMalignant Cystosarcoma Phyllodes

FLNA KMT2D

3.04e-055522C0600066
Diseasecognitive disorder (implicated_via_orthology)

CHRFAM7A CHRNA7

4.55e-056522DOID:1561 (implicated_via_orthology)
Diseaserheumatoid arthritis (biomarker_via_orthology)

CHRFAM7A CHRNA7

4.55e-056522DOID:7148 (biomarker_via_orthology)
Diseasereticulocyte count

ZNF469 C5orf67 AHNAK EMID1 ZBTB40 TAF2 PPP1R15A MIDEAS SLC12A5

7.91e-051045529EFO_0007986
DiseaseMental Retardation, Psychosocial

ZBTB40 TAF2 PRRT2 DYNC1H1

1.07e-04139524C0025363
DiseaseProfound Mental Retardation

ZBTB40 TAF2 PRRT2 DYNC1H1

1.07e-04139524C0020796
DiseaseMental deficiency

ZBTB40 TAF2 PRRT2 DYNC1H1

1.07e-04139524C0917816
Diseaseprotein CREG1 measurement

GOLGA8B RCSD1

1.09e-049522EFO_0801937
Diseaseirritable bowel syndrome symptom measurement

GAP43 CHRFAM7A CHRNA7

1.49e-0458523EFO_0021536
Diseasenicotine dependence (implicated_via_orthology)

CHRFAM7A CHRNA7

1.99e-0412522DOID:0050742 (implicated_via_orthology)
Diseasecollagen disease (implicated_via_orthology)

COL4A4 NFKBIB

1.99e-0412522DOID:854 (implicated_via_orthology)
DiseaseMood Disorders

VGF ANK3 GAP43 SLC12A5

2.22e-04168524C0525045
DiseasePetit mal status

ANK3 GAP43 SLC12A5

2.28e-0467523C0270823
DiseaseGrand Mal Status Epilepticus

ANK3 GAP43 SLC12A5

2.28e-0467523C0311335
DiseaseStatus Epilepticus, Subclinical

ANK3 GAP43 SLC12A5

2.28e-0467523C0751522
DiseaseSimple Partial Status Epilepticus

ANK3 GAP43 SLC12A5

2.28e-0467523C0751524
DiseaseNon-Convulsive Status Epilepticus

ANK3 GAP43 SLC12A5

2.28e-0467523C0751523
DiseaseComplex Partial Status Epilepticus

ANK3 GAP43 SLC12A5

2.28e-0467523C0393734
DiseaseStatus Epilepticus

ANK3 GAP43 SLC12A5

2.39e-0468523C0038220
Diseaserefractive error

COL4A4 ANK3 C16orf86 GOLGA8B NPAT

2.71e-04326525MONDO_0004892
Diseasereticulocyte measurement

FLNA ZNF469 C5orf67 AHNAK EMID1 ZBTB40 PPP1R15A MIDEAS

4.78e-041053528EFO_0010700
Diseasehair colour measurement

ZNF750 ZNF469 C5orf67 IL16 KMT2D AHNAK

7.22e-04615526EFO_0007822
DiseaseSeizures, Focal

DYNC1H1 CHRNA7 SLC12A5

8.29e-04104523C0751495
DiseaseEpilepsy

FLNA PRRT2 SLC12A5

9.50e-04109523C0014544
DiseaseIntellectual Disability

ZBTB40 TAF2 PRRT2 VPS53 DYNC1H1

1.13e-03447525C3714756
DiseaseBipolar Disorder

VGF ANK3 GAP43 CHRFAM7A CHRNA7

1.50e-03477525C0005586

Protein segments in the cluster

PeptideGeneStartEntry
EGPKLGEERPKPHAG

C16orf86

71

Q6ZW13
HAGEKGDPGPPGDHE

COL4A4

591

P53420
KGNKGDPASHFGPPG

COL4A4

1071

P53420
EGAAVKETPHSPPGG

RCSD1

341

Q6JBY9
KETPHSPPGGVKGGD

RCSD1

346

Q6JBY9
PDIDIHGPEGKLKGP

AHNAK

4101

Q09666
GADVTHPPAGDGKKP

AGO3

596

Q9H9G7
LGADVTHPPAGDGKK

AGO4

586

Q9HCK5
LHGGQPPEGDPDLAK

CHRNA7

421

P36544
ADVTHPPAGDGKKPS

AGO2

596

Q9UKV8
PHPDDSGKEDGLGPK

RBM20

796

Q5T481
PGSGAGEKHKEEPID

NPAT

1271

Q14207
PPNPKHAKTKEAGDG

PAGE4

86

O60829
GKEFEPKAAHPVPGS

GLOD5

86

A6NK44
HGAPEPEGEDEKSGP

NFKBIB

296

Q15653
PAGKESQEGPKHPTG

GPATCH8

521

Q9UKJ3
EEEGTQGHPDGTPPK

IL16

746

Q14005
HPETPKQKGDGRPET

NIPBL

721

Q6KC79
DVDFPSPGPHGGDKE

MUC5AC

3531

P98088
LHGGQPPEGDPDLAK

CHRFAM7A

331

Q494W8
ESPKVPGEGPGHSEA

PRRT2

16

Q7Z6L0
PENATAGPAEPHKGL

FZD9

156

O00144
GAGGEEGEHVKPFKP

HSPBAP1

16

Q96EW2
KLPGDGGSVPEKGKH

C5orf67

66

F2Z3F1
QHGAPGPGPADASKV

FLNA

2546

P21333
QHGPDGQGFPKAEEK

ANK3

2651

Q12955
GKGPEQNPAEHKPSV

MIDEAS

551

Q6PJG2
DAPQVSHKPGGEPKI

DYNC1H1

941

Q14204
RGEPGPKGDPGEKSH

EMID1

356

Q96A84
KGENGHPGSPGEKGE

COL13A1

526

Q5TAT6
PGAPAPQELGAADKH

GOLGA8B

521

A8MQT2
VPEENKPPSRHAGGK

SLC38A10

516

Q9HBR0
SDHGGKPPLPAEKPA

SLC38A10

646

Q9HBR0
HKETGKGEAAPGPQS

PPP1R15A

276

O75807
PRHLPGEDVKGDGNP

SLC12A5

31

Q9H2X9
PNSGHGPDGEVPKDK

IRF3

301

Q14653
KPGDGGSPSKPSDHE

IRS4

866

O14654
AGGHGEDRPEPLSPK

OGFR

366

Q9NZT2
GEHPSAAAPGPGKHK

RPUSD2

86

Q8IZ73
PKGDKAEDGFHGVSP

SUMF2

201

Q8NBJ7
DPAGPGDSKNPGDAK

SHD

56

Q96IW2
PDSGPLPETHKFGEG

VGF

236

O15240
APATGSKPDEPGKAG

GAP43

91

P17677
PIFGGGKEKDNPASH

TAF2

416

Q6P1X5
HPETKPGSLDGDGAP

ZNF750

596

Q32MQ0
GPAGPVSHPDGQEAK

ZSCAN5B

336

A6NJL1
KSGPGKAKEPGADPA

ZNF609

1061

O15014
GSKGEHPEGDPGEVP

TACC2

476

O95359
AGAGDPGKQQAPEKP

TACC2

1136

O95359
FKAQGPPKPNTDEGG

VPS53

451

Q5VIR6
QGPHGSLGPKEKGES

ZNF469

3771

Q96JG9
KLGTKRPHPEDGDGQ

ZSCAN18

366

Q8TBC5
KGPGAAVEPNGHPEA

TCHHL1

641

Q5QJ38
HRAGLPEDKGPEPVG

USP6

26

P35125
LEAHGAGGEPDAPKK

ZBTB40

786

Q9NUA8
GPAGELHAKVPSGQP

KMT2D

2501

O14686
APGPLEDKGLGTPEH

MYOG

46

P15173