Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	presynaptic endocytic zone membrane	AP2B1 CLTC DNM1	1.91e-05	14	80	3	GO:0098835
GeneOntologyCellularComponent	extracellular matrix	TRIL DST EPYC CSPG4 RTN4RL1 APLP1 MUC5B CPN2 CD180 LRRC15 GP1BA	3.92e-05	656	80	11	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	TRIL DST EPYC CSPG4 RTN4RL1 APLP1 MUC5B CPN2 CD180 LRRC15 GP1BA	4.03e-05	658	80	11	GO:0030312
GeneOntologyCellularComponent	presynaptic endocytic zone	AP2B1 CLTC DNM1	4.23e-05	18	80	3	GO:0098833
GeneOntologyCellularComponent	nuclear protein-containing complex	TRERF1 FOXO3 SMARCA5 KMT2D ANAPC1 AMOT INTS15 CLTC MED12L XPO4 MGA TRRAP SMAD1 RAD23B	6.77e-04	1377	80	14	GO:0140513
Domain	L_dom-like	TRIL FLII NLRP14 LRFN2 EPYC INSRR RTN4RL1 CPN2 CD180 NLRC3 LRRC15 GP1BA	1.68e-08	328	81	12	IPR032675
Domain	Leu-rich_rpt	TRIL FLII NLRP14 LRFN2 EPYC RTN4RL1 CPN2 CD180 NLRC3 LRRC15 GP1BA	2.42e-08	271	81	11	IPR001611
Domain	LRR_8	TRIL FLII LRFN2 EPYC RTN4RL1 CPN2 CD180 LRRC15 GP1BA	5.43e-08	171	81	9	PF13855
Domain	Leu-rich_rpt_typical-subtyp	TRIL FLII LRFN2 EPYC RTN4RL1 CPN2 CD180 LRRC15 GP1BA	7.30e-08	177	81	9	IPR003591
Domain	LRR_TYP	TRIL FLII LRFN2 EPYC RTN4RL1 CPN2 CD180 LRRC15 GP1BA	7.30e-08	177	81	9	SM00369
Domain	Cys-rich_flank_reg_C	TRIL LRFN2 RTN4RL1 CPN2 CD180 LRRC15 GP1BA	1.24e-07	90	81	7	IPR000483
Domain	LRRCT	TRIL LRFN2 RTN4RL1 CPN2 CD180 LRRC15 GP1BA	1.24e-07	90	81	7	SM00082
Domain	-	TRIL FLII NLRP14 LRFN2 EPYC RTN4RL1 CPN2 CD180 NLRC3 LRRC15 GP1BA	1.35e-07	321	81	11	3.80.10.10
Domain	LRR	TRIL FLII LRFN2 EPYC RTN4RL1 CPN2 CD180 LRRC15 GP1BA	2.16e-07	201	81	9	PS51450
Domain	LRRNT	TRIL LRFN2 EPYC RTN4RL1 CPN2 LRRC15 GP1BA	2.23e-07	98	81	7	IPR000372
Domain	LRRNT	TRIL LRFN2 EPYC RTN4RL1 CPN2 LRRC15 GP1BA	2.23e-07	98	81	7	SM00013
Domain	LRR_1	TRIL FLII LRFN2 RTN4RL1 CPN2 CD180 LRRC15	4.61e-05	219	81	7	PF00560
Domain	LRRNT	EPYC RTN4RL1 CPN2 GP1BA	8.18e-05	53	81	4	PF01462
Domain	FAT	TMTC1 TRRAP	2.76e-04	6	81	2	PF02259
Domain	PIK-rel_kinase_FAT	TMTC1 TRRAP	2.76e-04	6	81	2	IPR003151
Domain	LRRCT	TRIL CPN2 CD180	3.56e-04	32	81	3	PF01463
Domain	Kinase-like_dom	CDK18 DST INSRR RIPK4 MAP3K15 DNM1 TRRAP RPS6KC1	2.40e-03	542	81	8	IPR011009
Domain	USP_CS	USP44 USP31 USP32	2.95e-03	66	81	3	IPR018200
Domain	USP_1	USP44 USP31 USP32	3.49e-03	70	81	3	PS00972
Domain	UCH	USP44 USP31 USP32	3.63e-03	71	81	3	PF00443
Domain	USP_2	USP44 USP31 USP32	3.63e-03	71	81	3	PS00973
Domain	USP_3	USP44 USP31 USP32	3.78e-03	72	81	3	PS50235
Domain	USP_dom	USP44 USP31 USP32	3.78e-03	72	81	3	IPR028889
Domain	Peptidase_C19_UCH	USP44 USP31 USP32	3.78e-03	72	81	3	IPR001394
Domain	NACHT	NLRP14 NLRC3	4.43e-03	23	81	2	PS50837
Domain	NACHT_NTPase	NLRP14 NLRC3	4.43e-03	23	81	2	IPR007111
Pathway	REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING	AP2B1 CLTC DNM1	2.45e-05	14	59	3	M10122
Pubmed	Clint: a novel clathrin-binding ENTH-domain protein at the Golgi.	AP2B1 CLTC DNM1	1.01e-06	9	81	3	12429846
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	DENND4A DST ATXN1 AMOT CLTC MED12L BCL3 MGA PLCE1	2.42e-06	497	81	9	23414517
Pubmed	The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes.	SMARCA5 KMT2D TRRAP	3.42e-06	13	81	3	16510874
Pubmed	APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development.	AP2B1 CLTC DNM1	4.35e-06	14	81	3	29262337
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TENM3 MYH7B MBD5 PLCE1 WDR48	4.43e-06	103	81	5	10819331
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	USP31 TRIL LRFN2 TENM3 CLTC URB2 PLCE1 WDR48	5.01e-06	407	81	8	12693553
Pubmed	Hyperthermia induces platelet apoptosis and glycoprotein Ibalpha ectodomain shedding.	TRIM33 GP1BA	5.36e-06	2	81	2	20158380
Pubmed	Maternal diabetes and high glucose in vitro trigger Sca1+ cardiac progenitor cell apoptosis through FoxO3a.	FOXO3 ATXN1	5.36e-06	2	81	2	27856257
Pubmed	Interaction of transcription factor FoxO3 with histone acetyltransferase complex subunit TRRAP modulates gene expression and apoptosis.	FOXO3 TRRAP	5.36e-06	2	81	2	35151693
Pubmed	Abnormal expression levels of BMP15/Smad1 are associated with granulosa cell apoptosis in patients with polycystic ovary syndrome.	SMAD1 BMP15	5.36e-06	2	81	2	28983616
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SMARCA5 KMT2D CEP85 ANAPC1 AMOT CLTC NAA30 MGA TRRAP	5.42e-06	549	81	9	38280479
Pubmed	Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program.	SMARCA5 KMT2D TRRAP	5.43e-06	15	81	3	16510875
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TRERF1 FLII DST AP2B1 IQGAP2 ANAPC1 CLTC SIPA1 DNM1 MGA LRRC15	1.43e-05	963	81	11	28671696
Pubmed	Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells.	CLTC DNM1	1.60e-05	3	81	2	24431429
Pubmed	Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.	AP2B1 CLTC	1.60e-05	3	81	2	19509056
Pubmed	The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.	AP2B1 CLTC	1.60e-05	3	81	2	10097102
Pubmed	Endocytosis of FcalphaR is clathrin and dynamin dependent, but its cytoplasmic domain is not required.	CLTC DNM1	1.60e-05	3	81	2	19859085
Pubmed	TRIM33 protects osteoblasts from oxidative stress-induced apoptosis in osteoporosis by inhibiting FOXO3a ubiquitylation and degradation.	FOXO3 TRIM33	1.60e-05	3	81	2	34101965
Pubmed	CircFOXO3 functions as a molecular sponge for miR-143-3p to promote the progression of gastric carcinoma via upregulating USP44.	USP44 FOXO3	1.60e-05	3	81	2	32445925
Pubmed	MAP1B and clathrin are novel interacting partners of the giant cyto-linker dystonin.	DST CLTC	1.60e-05	3	81	2	21936565
Pubmed	Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells.	CLTC DNM1	3.20e-05	4	81	2	10336464
Pubmed	Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor.	AP2B1 CLTC	3.20e-05	4	81	2	17267500
Pubmed	Dyrk1A binds to multiple endocytic proteins required for formation of clathrin-coated vesicles.	CLTC DNM1	3.20e-05	4	81	2	19722700
Pubmed	Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin.	CLTC APLP1	3.20e-05	4	81	2	14563850
Pubmed	Mammalian actin-binding protein 1/HIP-55 is essential for the scission of clathrin-coated pits by regulating dynamin-actin interaction.	CLTC DNM1	3.20e-05	4	81	2	25690657
Pubmed	Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development.	AP2B1 CLTC DNM1	3.82e-05	28	81	3	26884322
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TRIM33 FLII RAP1GDS1 CEP85 DST AP2B1 ZNF532 USP32 CLTC RIPK4 DNM1 RAD23B	4.13e-05	1285	81	12	35914814
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	SMARCA5 ANAPC1 CLTC MGA TRRAP WDR48	4.30e-05	272	81	6	31010829
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	TRIM33 SMARCA5 KMT2D MGA TRRAP	4.59e-05	167	81	5	20362541
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	TRIM33 FLII SMARCA5 AP2B1 IQGAP2 ACADSB ANAPC1 CLTC	4.93e-05	560	81	8	35241646
Pubmed	ARF6 regulates angiotensin II type 1 receptor endocytosis by controlling the recruitment of AP-2 and clathrin.	AP2B1 CLTC	5.33e-05	5	81	2	17719203
Pubmed	Balancing BMP signaling through integrated inputs into the Smad1 linker.	FOXO3 SMAD1	5.33e-05	5	81	2	17289590
Pubmed	Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin.	CLTC DNM1	5.33e-05	5	81	2	21169560
Pubmed	Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C epsilon.	SMAD1 PLCE1	5.33e-05	5	81	2	15743817
Pubmed	ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2.	AP2B1 CLTC	5.33e-05	5	81	2	12221107
Pubmed	Novel binding sites on clathrin and adaptors regulate distinct aspects of coat assembly.	AP2B1 CLTC	5.33e-05	5	81	2	17052248
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TRERF1 KMT2D DST ZNF532 ANAPC1 AMOT MGA	5.58e-05	418	81	7	34709266
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	TRIM33 KMT2D CEP85 ATXN1 MGA	7.26e-05	184	81	5	32908313
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TRERF1 UBR1 FLII SMARCA5 KMT2D ANAPC1 CLTC TRRAP MN1	7.99e-05	774	81	9	15302935
Pubmed	Molecular components required for resting and stimulated endocytosis of botulinum neurotoxins by glutamatergic and peptidergic neurons.	CLTC DNM1	7.99e-05	6	81	2	23640057
Pubmed	FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination.	TRIM33 SMAD1	7.99e-05	6	81	2	19135894
Pubmed	A local, periactive zone endocytic machinery at photoreceptor synapses in close vicinity to synaptic ribbons.	CLTC DNM1	7.99e-05	6	81	2	23785143
Pubmed	Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin.	AP2B1 CLTC	7.99e-05	6	81	2	12732633
Pubmed	A clathrin-dynamin-dependent endocytic pathway for the uptake of HIV-1 by direct T cell-T cell transmission.	CLTC DNM1	7.99e-05	6	81	2	18602423
Pubmed	Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis.	SIPA1 GP1BA	7.99e-05	6	81	2	29802205
Pubmed	Identification and characterization of a nerve terminal-enriched amphiphysin isoform.	CLTC DNM1	7.99e-05	6	81	2	9195986
Pubmed	Genome-wide association study of multiplex schizophrenia pedigrees.	TMTC1 TENM3	7.99e-05	6	81	2	22885689
Pubmed	Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo.	AP2B1 CLTC	7.99e-05	6	81	2	15533940
Pubmed	Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites.	AP2B1 CLTC	7.99e-05	6	81	2	10748223
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	FOXO3 CDK18 DENND4A CEP85 DST ANAPC1 AMOT	8.36e-05	446	81	7	24255178
Pubmed	SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1.	CLTC DNM1	1.12e-04	7	81	2	16137687
Pubmed	Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction.	CLTC DNM1	1.12e-04	7	81	2	34018922
Pubmed	Clathrin interacts specifically with amphiphysin and is displaced by dynamin.	CLTC DNM1	1.12e-04	7	81	2	9280305
Pubmed	Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.	AP2B1 CLTC	1.12e-04	7	81	2	16314522
Pubmed	The novel Nrf2-interacting factor KAP1 regulates susceptibility to oxidative stress by promoting the Nrf2-mediated cytoprotective response.	TRIM33 CLTC	1.12e-04	7	81	2	21382013
Pubmed	Novel Cul3 binding proteins function to remodel E3 ligase complexes.	LRFN2 RTN4RL1 WDR48	1.13e-04	40	81	3	25011449
Pubmed	A human MAP kinase interactome.	RAP1GDS1 DST AP2B1 ATXN1 CLTC MBD5 MGA	1.42e-04	486	81	7	20936779
Pubmed	A transcriptional Map of the FMF region.	OR1F1 OR1F2P	1.49e-04	8	81	2	9653642
Pubmed	Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice.	CLTC DNM1	1.49e-04	8	81	2	11879655
Pubmed	An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse.	FOXO3 SMARCA5	1.49e-04	8	81	2	15890782
Pubmed	A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication.	FOXO3 CDK18 CEP85 AMOT RPGR	1.61e-04	218	81	5	19460752
Pubmed	Interaction network of human early embryonic transcription factors.	TRERF1 TRIM33 SMARCA5 KMT2D ATXN1 MGA	1.74e-04	351	81	6	38297188
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	TMTC1 RAP1GDS1 EPYC AMOT PNMA8A XPO4 CPN2 TCEANC	1.99e-04	686	81	8	29987050
Pubmed	Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility.	CSPG4 CLTC	2.38e-04	10	81	2	26437238
Pubmed	CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.	AP2B1 CLTC	2.38e-04	10	81	2	25898166
Pubmed	Pygo2 associates with MLL2 histone methyltransferase and GCN5 histone acetyltransferase complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion.	KMT2D TRRAP	2.38e-04	10	81	2	20937768
Pubmed	Protein partners of dynamin-1 in the retina.	CLTC DNM1	2.38e-04	10	81	2	23746204
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FOXO3 FLII KMT2D TKFC DST CSPG4 PLA2G6 MBD5 TRRAP ZNF614	2.45e-04	1105	81	10	35748872
Pubmed	Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes.	AP2B1 CLTC DNM1	2.48e-04	52	81	3	20114047
Pubmed	CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.	FOXO3 NLRP14 BMP15	2.62e-04	53	81	3	24357321
Pubmed	Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.	FOXO3 SMAD1	2.91e-04	11	81	2	15084259
Pubmed	Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy.	KMT2D OTULIN URB2 LRRC15	3.03e-04	137	81	4	30862715
Pubmed	Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling.	TRIM33 SMAD1	3.48e-04	12	81	2	19917253
Pubmed	NODs: intracellular proteins involved in inflammation and apoptosis.	NLRP14 NLRC3	3.48e-04	12	81	2	12766759
Pubmed	Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.	AP2B1 CLTC RPS6KC1	3.78e-04	60	81	3	34761192
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	KMT2D DST INTS15 MGA TRRAP WDR48	3.99e-04	410	81	6	26949251
Pubmed	FCHo proteins are nucleators of clathrin-mediated endocytosis.	CLTC DNM1	4.11e-04	13	81	2	20448150
Pubmed	EphrinA2 regulates clathrin mediated KSHV endocytosis in fibroblast cells by coordinating integrin-associated signaling and c-Cbl directed polyubiquitination.	AP2B1 CLTC	4.11e-04	13	81	2	23874206
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	TRERF1 TRIM33 KMT2D ATXN1 MGA	4.16e-04	268	81	5	33640491
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	TRIM33 DST TENM3 IQGAP2 AMOT CLTC RPGR MGA	4.58e-04	777	81	8	35844135
Pubmed	Functional proteomics mapping of a human signaling pathway.	KMT2D DST TENM3 MACO1 CSPG4 MGA SMAD1	4.64e-04	591	81	7	15231748
Pubmed	Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor.	AP2B1 CLTC	4.79e-04	14	81	2	11157096
Pubmed	Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation.	CLTC DNM1	4.79e-04	14	81	2	20802490
Pubmed	USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.	USP44 RAD23B	4.79e-04	14	81	2	27880911
Pubmed	Redundant and nonredundant organismal functions of EPS15 and EPS15L1.	CLTC DNM1	4.79e-04	14	81	2	30692166
Pubmed	Neuropilin 1 balances β8 integrin-activated TGFβ signaling to control sprouting angiogenesis in the brain.	CSPG4 SMAD1	4.79e-04	14	81	2	26586223
Pubmed	Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.	AP2B1 CLTC	4.79e-04	14	81	2	16903783
Pubmed	PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.	KMT2D MGA TRRAP	4.79e-04	65	81	3	22496869
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	TRERF1 AP2B1 ZNF532 CLTC MGA SMAD1	5.12e-04	430	81	6	35044719
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	USP44 AP2B1 ACADSB AMOT USP32 TRRAP LRRC15 WDR48 RAD23B	5.50e-04	1005	81	9	19615732
Pubmed	LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.	CLTC DNM1	5.52e-04	15	81	2	21307259
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SMARCA5 ANAPC1 AMOT CLTC TRRAP RPS6KC1	5.78e-04	440	81	6	34244565
Pubmed	A protein interaction landscape of breast cancer.	DST AP2B1 CLTC MUC5B SIPA1 WDR48 RAD23B	7.01e-04	634	81	7	34591612
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	TRIM33 KMT2D RAP1GDS1 TKFC CEP85 PPCS	7.04e-04	457	81	6	32344865
Pubmed	Transcriptional intermediary factor 1γ binds to the anaphase-promoting complex/cyclosome and promotes mitosis.	TRIM33 ANAPC1	7.12e-04	17	81	2	23160376
Pubmed	The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module.	AP2B1 CLTC	8.00e-04	18	81	2	10567358
Pubmed	USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier.	SMARCA5 TRRAP	8.00e-04	18	81	2	17846119
Pubmed	In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly.	CLTC DNM1	8.00e-04	18	81	2	9463375
Pubmed	TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation.	TRIM33 SMARCA5	8.00e-04	18	81	2	28068325
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	UBR1 DENND4A CEP85 DST DNM1 PLCE1 WDR48	8.11e-04	650	81	7	38777146
Interaction	DACT2 interactions	TKFC TRRAP MLYCD WDR48	3.84e-07	16	79	4	int:DACT2
Interaction	CCDC138 interactions	CEP85 AP2B1 AMOT RIPK4 TCEANC TRRAP	8.83e-06	123	79	6	int:CCDC138
Interaction	YWHAB interactions	FOXO3 USP31 TRIM33 CDK18 DENND4A TKFC DST ATXN1 AMOT USP32 CLTC RIPK4 SIPA1 TRRAP	3.55e-05	1014	79	14	int:YWHAB
Interaction	SMC1A interactions	SMARCA5 ATXN1 AMOT USP32 RIPK4 RPGR DNM1 MGA TRRAP	3.72e-05	418	79	9	int:SMC1A
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRFN2 TENM3 DNM1 LRRC15 PLCE1	9.74e-06	156	81	5	dd41ed918b07fa248da458a629b3c53cb7ea8764
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRFN2 TENM3 DNM1 LRRC15 PLCE1	9.74e-06	156	81	5	abf9dd075b1ca8f613c660cc82f8a5af071fb6ab
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-TRGV2_gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RAP1GDS1 ATXN1 MGA NLRC3 KLRC2	1.43e-05	169	81	5	8caf7996796a2e2716e3855de855c903d6126bf2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRFN2 DST TENM3 IQGAP2 PLCE1	1.56e-05	172	81	5	6c17a1e586a72d1bd80c20c06370429c61dc9f85
ToppCell	COVID-19-Heart-Lymph_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TMTC1 RPGR SMAD1 LRRC15 PLCE1	1.79e-05	177	81	5	326fde0734ef0d7272693966d346ca479b9d8147
ToppCell	wk_15-18-Mesenchymal-Chondrocyte-ASPN+_chondrocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TMTC1 AMOT CSPG4 MN1 REV1	1.84e-05	178	81	5	a55130670aa95a87b833dd3cd2de461d779e4c06
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LRFN2 DST TENM3 IQGAP2 PLCE1	1.89e-05	179	81	5	7394e77e665bf16d3733df91bb12907be460ab44
ToppCell	facs-Marrow-B-cells-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIL LRFN2 CSPG4 PNMA8A APLP1	1.94e-05	180	81	5	c54af6fb11484dacd3efa1f10a487376ff820a5e
ToppCell	facs-Marrow-B-cells-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIL LRFN2 CSPG4 PNMA8A APLP1	1.94e-05	180	81	5	07ac979b21be2425294d9818c48b5a1e6f014c19
ToppCell	wk_15-18-Mesenchymal-Chondrocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TMTC1 TENM3 EPYC AMOT CSPG4	1.99e-05	181	81	5	8950844b3e65c7028d80da5787ae2ce509c3d52d
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-2\|TCGA-Skin / Sample_Type by Project: Shred V9	USP31 CEP85 AP2B1 USP32 CLTC	1.99e-05	181	81	5	9d5b331cabc5524f0a9fd8b571e87be4c447c7d4
ToppCell	Control-T_cells-NK_cells\|Control / group, cell type (main and fine annotations)	TRERF1 LRFN2 IQGAP2 NLRC3 KLRC2	2.21e-05	185	81	5	755c0998c729f462399f1d5e88adf4bfae31be30
ToppCell	facs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST TENM3 INSRR ZFHX2 APLP1	2.39e-05	188	81	5	a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Mesenchymal_3\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	HIC1 TENM3 AMOT APLP1 MN1	2.65e-05	192	81	5	d88753b200d9c8da6716222d697ddf0a1548d6c8
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	TRIM33 SMARCA5 USP32 CLTC MGA	2.71e-05	193	81	5	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST TENM3 CLTC INSRR ZFHX2	2.85e-05	195	81	5	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST CLTC INSRR APLP1 MGA	2.85e-05	195	81	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST CLTC INSRR APLP1 MGA	2.85e-05	195	81	5	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRIL HIC1 TENM3 MN1 PLCE1	2.92e-05	196	81	5	308fa54385ca34e9e590967d4553b84aad96c92f
ToppCell	10x5'v1-week_12-13-Mesenchymal_osteo-stroma-early_osteoblast\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	TENM3 EPYC APLP1 CPN2 LRRC15	2.99e-05	197	81	5	2ca5ebb708935a90b12b8e98a22ae2d664ed002e
ToppCell	COVID-19_Mild-Neu_0\|World / 5 Neutrophil clusters in COVID-19 patients	TENM3 MACO1 INSRR LRRC15	1.24e-04	140	81	4	93f024473b1bb3bf93ae776fd6a8fc5e93d013f0
ToppCell	Club-club-1\|World / Class top	NOXA1 DNM1 TCEANC	1.30e-04	54	81	3	48f80b20b1c4995a0f7084d31666781dce4009a9
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LRFN2 TENM3 DNM1 PLCE1	1.58e-04	149	81	4	cc6224c6b79f43b97adc1ce48ca4906bff2ad318
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LRFN2 TENM3 DNM1 PLCE1	1.58e-04	149	81	4	24a7538b54b2a5291503c7493fefed4e45e8d710
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LRFN2 TENM3 DNM1 PLCE1	1.97e-04	158	81	4	e7db0ee4740e3c7a4d97d7cd7462e2c2ab458a4b
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LRFN2 TENM3 DNM1 PLCE1	1.97e-04	158	81	4	d39e020c3e77eb9d3de600a171d22f94357061d4
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-Neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND4A USP32 MED12L RUFY4	2.12e-04	161	81	4	e227f7b711475624cf80e77f235b1783d88d57b4
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-neutrophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND4A USP32 MED12L RUFY4	2.12e-04	161	81	4	8280a029026c272cae9649b27575831b0dd4e242
ToppCell	Fetal_29-31_weeks-Immune-mast_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	IQGAP2 MED12L NLRC3 GP1BA	2.22e-04	163	81	4	03b2ec226adffba3ce893f3d12e549c841e662fd
ToppCell	10x5'-Liver-Lymphocytic_Invariant-Inducer-like-ILC3\|Liver / Manually curated celltypes from each tissue	DST CSPG4 NOXA1 MAP3K15	2.22e-04	163	81	4	7f61483eeb1fde21843c6391468e13cb0cc2a89f
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRIL HIC1 DNM1 MN1	2.28e-04	164	81	4	d167c7a987b9b35d1e7725c803df4f9cd5380e47
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-BM_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIC1 RTN4RL1 APLP1 NLRC3	2.38e-04	166	81	4	aa2df07eff323ded751ced8938af08223d7f2029
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIC1 RTN4RL1 APLP1 NLRC3	2.38e-04	166	81	4	695298a94d62b8adab083900003ec636fbaae5d9
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 CSPG4 RTN4RL1 BCL3	2.44e-04	167	81	4	b4ef07117d14da3d5fbced949e4dfcb01c392295
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 CSPG4 RTN4RL1 BCL3	2.44e-04	167	81	4	94fc7df7ca55cd722a8dbd153201a29891217473
ToppCell	Adult-Immune-natural_killer_cell-D122\|Adult / Lineage, Cell type, age group and donor	TRERF1 IQGAP2 NLRC3 KLRC2	2.44e-04	167	81	4	ff1ce3b1a2d91d2ad979f25899db4f4eeb865892
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMTC1 CSPG4 RTN4RL1 BCL3	2.44e-04	167	81	4	eff3723fe60755272eca237459165e436e919ece
ToppCell	LA-16._Neuronal\|World / Chamber and Cluster_Paper	TENM3 IQGAP2 RPGR PLCE1	2.49e-04	168	81	4	2fd1fd2a16ac1c5eb028f93cc3a2477c7747693e
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRERF1 TENM3 IQGAP2 RPGR	2.49e-04	168	81	4	b87fc63f9e35dfcfc46cb129ea569e73c5e018bb
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRERF1 TENM3 IQGAP2 RPGR	2.49e-04	168	81	4	b96a48552f4236a95bbcdce2f1b05041086d7101
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DST TENM3 IQGAP2 PLCE1	2.49e-04	168	81	4	315ca578c945aeeb77acda2727f3e6db8b43f43e
ToppCell	COVID-19-kidney-PEC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LRFN2 TENM3 DNM1 PLCE1	2.49e-04	168	81	4	a086c306be430adf0632ba53e98cd8014d2de330
ToppCell	LV-16._Neuronal\|LV / Chamber and Cluster_Paper	TENM3 IQGAP2 RPGR PLCE1	2.55e-04	169	81	4	a8fc8ab0f0757e939e213efb61c03cfe390bf7d2
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 TMTC1 TENM3 TCEANC	2.61e-04	170	81	4	fa753cc8fbd04e63c9a303da4dc17ee2ce907f92
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 TMTC1 TENM3 TCEANC	2.61e-04	170	81	4	03044e1436443b28dd39d5ef4fdb25c18e3a7546
ToppCell	Endothelial-B-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	TRIL TMTC1 HIC1 TENM3	2.67e-04	171	81	4	07ff7059071da83da1d8f266a586573920d75b58
ToppCell	droplet-Lung-21m-Hematologic-lymphocytic-mature_NK_T_cell-mature_NK_T_cell_l44\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IQGAP2 RTN4RL1 MLYCD RAD23B	2.79e-04	173	81	4	b6bb2a136a40f0946bbcde8d5972d3f059d080c7
ToppCell	tumor_Lymph_Node_/_Brain-B_lymphocytes-Undetermined\|B_lymphocytes / Location, Cell class and cell subclass	TRERF1 CDK18 HIC1 RIPK4	2.85e-04	174	81	4	390bd41ef114464f3db3e0cac4e67fe7571b4c23
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND4A INSRR ZFHX2 RTN4RL1	2.85e-04	174	81	4	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	Children_(3_yrs)-Immune-natural_killer_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TRERF1 IQGAP2 NLRC3 KLRC2	2.85e-04	174	81	4	33d6b81f31bfcb9c4b30206d88e20b9a94fba4a2
ToppCell	wk_15-18-Mesenchymal-Chondrocyte-intermediate_chondrocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TMTC1 TENM3 EPYC AMOT	2.91e-04	175	81	4	a84965d28438a4228d841b357c2cd75cf4b59a63
ToppCell	COPD-Lymphoid-ILC_A\|World / Disease state, Lineage and Cell class	TRERF1 IQGAP2 NLRC3 KLRC2	2.91e-04	175	81	4	e773e330de36f8a0aa9398a176ed7edb5599c582
ToppCell	COPD-Lymphoid-ILC_A\|COPD / Disease state, Lineage and Cell class	TRERF1 PLA2G6 NLRC3 KLRC2	2.98e-04	176	81	4	484452cb38fe4604f0910a068361ed461b5b0c21
ToppCell	facs-Brain_Myeloid-Striatum-24m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRERF1 AMOT MBD5 TRRAP	3.04e-04	177	81	4	f6b9d91d46830d0d207b0abd4ee5a4942fd99774
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TRIM33 MACO1 APLP1 PLA2G6	3.11e-04	178	81	4	9d575902d3dbe33437c9d4200df093a741269803
ToppCell	COVID-19-kidney-Epi_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	DST TENM3 DNM1 PLCE1	3.17e-04	179	81	4	e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCell	E15.5-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TRIL HIC1 ACADSB RBM46	3.17e-04	179	81	4	b559f5a72cc9e3e35d05cb539b5c2e006e56e652
ToppCell	P28-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TENM3 IQGAP2 CSPG4 TCEANC	3.24e-04	180	81	4	1e819c5c87704ec6535dfeaae56561895e239d07
ToppCell	facs-Heart-RV-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDK18 CSPG4 MAP3K15 PLCE1	3.24e-04	180	81	4	a37cc885fe3f6cb9df69d43358064c83c18412e7
ToppCell	facs-Heart-RV-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDK18 CSPG4 MAP3K15 PLCE1	3.24e-04	180	81	4	63a6d532b16b8b15c7c9102148d7297ee3afd641
ToppCell	Adult-Immune-natural_killer_cell-D175\|Adult / Lineage, Cell type, age group and donor	TRERF1 LRFN2 IQGAP2 NLRC3	3.24e-04	180	81	4	fc59e28f39e7d4fb1bcc7205202cf39224b70d7b
ToppCell	Adult-Immune-T_lymphocyte-D122\|Adult / Lineage, Cell type, age group and donor	TRERF1 IQGAP2 NLRC3 KLRC2	3.24e-04	180	81	4	06c371d0f0c5a7b234dd143e98800e19af95a8b5
ToppCell	facs-Marrow-B-cells-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RTN4RL1 PLA2G6 URB2 WDR48	3.24e-04	180	81	4	7368ab31c3273374ef260f0d710d4eea83cbc4a2
ToppCell	E18.5-samps-Mesenchymal-Pericyte\|E18.5-samps / Age Group, Lineage, Cell class and subclass	HIC1 CSPG4 RTN4RL1 PLCE1	3.24e-04	180	81	4	0b1d370db64862fe1c7ea0ffaf06d03ec82e6e70
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LRFN2 TENM3 DNM1 PLCE1	3.31e-04	181	81	4	5f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LRFN2 TENM3 DNM1 PLCE1	3.31e-04	181	81	4	c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCell	facs-Lung-Endomucin-24m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP85 CSPG4 RTN4RL1 RBM46	3.38e-04	182	81	4	be9c312a44868d4ee266a64d066feb8c5bce5687
ToppCell	facs-Lung-Endomucin-24m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP85 CSPG4 RTN4RL1 RBM46	3.38e-04	182	81	4	74dbb706bcaa0f8c922bf3b0424bce5bb27167fa
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KMT2D INSRR APLP1 MAP3K15	3.38e-04	182	81	4	1923932a9c60e9ec33db69ded441210d1fb07bec
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRIL DST TENM3 SMAD1	3.38e-04	182	81	4	53c267ee327e116dbd89d5927ed3bdf78d25ee62
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KMT2D INSRR APLP1 MAP3K15	3.38e-04	182	81	4	69ff652f74cc47fbe0bd665ab17c445c5b959dad
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	USP44 CSPG4 RTN4RL1 PLCE1	3.45e-04	183	81	4	4060d979948e1dd7507977629a7fbdfa4ca65bb6
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DST TENM3 SMAD1 LRRC15	3.45e-04	183	81	4	4d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LRFN2 TENM3 IQGAP2 PLCE1	3.45e-04	183	81	4	848fc6dd129150897ee339343e83c645b6e779eb
ToppCell	facs-Heart-RA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBR1 CSPG4 RTN4RL1 PLCE1	3.45e-04	183	81	4	0f02136359787bd78146617990968baa47a65d86
ToppCell	PND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	USP44 CSPG4 RTN4RL1 PLCE1	3.45e-04	183	81	4	0d44a978221cf3f733704bf11863502805fba733
ToppCell	facs-Heart-RA-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBR1 CSPG4 RTN4RL1 PLCE1	3.45e-04	183	81	4	2f0dcc65ad4d90ef946919b4462280fdd20c5ea0
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TMTC1 TENM3 EPYC CSPG4	3.60e-04	185	81	4	8ed10ba581849c9c4ac4397226be2b62b4b3b900
ToppCell	metastatic_Brain-Endothelial_cells-Stalk-like_ECs\|metastatic_Brain / Location, Cell class and cell subclass	TMTC1 HIC1 AMOT RPGR	3.60e-04	185	81	4	ad52970e88e8947ef256095bd4b40229b912d58a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DST TENM3 IQGAP2 PLCE1	3.60e-04	185	81	4	9197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LRFN2 TENM3 DNM1 PLCE1	3.60e-04	185	81	4	34fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DST TENM3 IQGAP2 PLCE1	3.60e-04	185	81	4	ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 IQGAP2 NLRC3 KLRC2	3.60e-04	185	81	4	45890fa81c65a48f4fdec164a4c8d0e2831243c0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRERF1 IQGAP2 NLRC3 KLRC2	3.60e-04	185	81	4	585bcfdff85bf43f5aa4cd1b39f7dcf1c78d7b02
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DST TENM3 IQGAP2 PLCE1	3.60e-04	185	81	4	b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TMTC1 TENM3 EPYC CSPG4	3.60e-04	185	81	4	b8052cebb73f41abe6faf0aa847be7c8ef23ae94
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LRFN2 TENM3 DNM1 PLCE1	3.60e-04	185	81	4	8816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRIL DST TENM3 SMAD1	3.67e-04	186	81	4	40070d9cd20188ba49b32acfca9bc16256b38bf5
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DST IQGAP2 APLP1 PLCE1	3.75e-04	187	81	4	24c2a3962da364e46e98abeab5f8234376fa26bb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRFN2 TENM3 DNM1 PLCE1	3.82e-04	188	81	4	b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRFN2 TENM3 DNM1 PLCE1	3.82e-04	188	81	4	874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDK18 CSPG4 RTN4RL1 PLCE1	3.82e-04	188	81	4	a906c29e3fda22eecfec3e5cac706c417bf2b7a4
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	USP31 TMTC1 TENM3 MN1	3.90e-04	189	81	4	e60a3d6aa84788c29f23439f1c747431ea581bc3
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CDK18 HIC1 CSPG4 PLCE1	3.90e-04	189	81	4	26cfe5b7e7f477f225f4e9f25f983f432f01e183
ToppCell	COVID-19-T_cells-NK_cells\|COVID-19 / group, cell type (main and fine annotations)	TRERF1 LRFN2 IQGAP2 KLRC2	3.90e-04	189	81	4	b699152dfbb8cd8ed724e1e5a51838f29b681b62
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RTN4RL1 RPGR SMAD1 LRRC15	3.98e-04	190	81	4	876bd2eb9ed2624cb23bdcf6b989e4fa34d099e3
ToppCell	E17.5-Mesenchymal-developing_mesenchymal_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CDK18 HIC1 CSPG4 PLCE1	3.98e-04	190	81	4	2ab604d35456beba71c25511e0f819000e6642d2
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDK18 CSPG4 RTN4RL1 PLCE1	3.98e-04	190	81	4	951e067d14412db67dc3babcdf61e41717d7b429
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RTN4RL1 RPGR SMAD1 LRRC15	3.98e-04	190	81	4	be9f36127028f52ca5fc1b32ba15a6c26aad69ac
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RTN4RL1 RPGR SMAD1 LRRC15	3.98e-04	190	81	4	09a8855901c3c9332dbaab3e40166485b696d0f1
Disease	3-hydroxyanthranilate 3;4-dioxygenase measurement	CPN2 LRRC15	6.86e-05	5	78	2	EFO_0021997
Disease	Abnormal corpus callosum morphology	MED12L MN1	1.03e-04	6	78	2	C1842581
Disease	leucine-rich repeat-containing protein 15 measurement	CPN2 LRRC15	1.44e-04	7	78	2	EFO_0801761
Disease	Adenocarcinoma of lung (disorder)	FOXO3 TRIM33 INSRR MAP3K15 RPS6KC1	2.21e-04	206	78	5	C0152013
Disease	gastric adenocarcinoma (is_implicated_in)	KMT2D PLCE1	3.74e-04	11	78	2	DOID:3717 (is_implicated_in)
Disease	glucose homeostasis measurement, glucose effectiveness measurement	TMTC1 MYH7B	7.08e-04	15	78	2	EFO_0006833, EFO_0006896
Disease	T-Cell Lymphoma	KMT2D MGA	8.08e-04	16	78	2	C0079772
Disease	migraine disorder, systolic blood pressure	HIC1 PLCE1	1.03e-03	18	78	2	EFO_0006335, MONDO_0005277
Disease	creatinine measurement	FOXO3 CDK18 HIC1 MYH7B CSPG4 USP32 PLA2G6 MBD5 NLRC3	1.23e-03	995	78	9	EFO_0004518
Disease	Dyslipidemias	MACO1 BCL3	1.83e-03	24	78	2	C0242339
Disease	Dyslipoproteinemias	MACO1 BCL3	1.83e-03	24	78	2	C0598784
Disease	migraine disorder, pulse pressure measurement	HIC1 PLCE1	2.15e-03	26	78	2	EFO_0005763, MONDO_0005277
Disease	Adenoid Cystic Carcinoma	FOXO3 INSRR MGA	2.39e-03	100	78	3	C0010606

Protein segments in the cluster

Peptide	Gene	Start	Entry
ENQNPQGRQLLLVSL	URB2	1046	Q14146
GNPSENRSLLAIHQQ	AMOT	26	Q4VCS5
HLQGNQLQALPRRLF	CPN2	151	P22792
HPNSNLLDLNPQNIN	AP2B1	191	P63010
QPHFLQSQLAAGQLV	CSPG4	1771	Q6UVK1
QLHNRRNENLQLGPL	CDK18	36	Q07002
NQSLGLLDQNPHLAQ	APLP1	461	P51693
LLNITNNGIHFAPLQ	ACADSB	41	P45954
QQQQQHLSRAPGLIT	ATXN1	221	P54253
LNLSHNEPLGLQSQA	CD180	401	Q99467
AHNARLTPLQFGNLQ	MUC5B	221	Q9HC84
NNLHQQLAKLQQRPR	DENND4A	521	Q7Z401
LQNNRIGLLQPGHFS	RTN4RL1	61	Q86UN2
IGRENPQLLQQISQH	RAD23B	306	P54727
RQHLNGQISPNSENL	RBM46	316	Q8TBY0
SLRALLGQALPHQAQ	NOXA1	336	Q86UR1
LGQALPHQAQLGQLS	NOXA1	341	Q86UR1
HNNLLQLVISGPVQQ	INTS15	381	Q96N11
HPNALNLQLRQLQPA	ANAPC1	31	Q9H1A4
RLLQLNHPTLSQNQH	PNMA8A	126	Q86V59
LQTLVLNGNPLLHAQ	FLII	176	Q13045
LNGNPLLHAQLRQLP	FLII	181	Q13045
PLTGSQRLNHQALQQ	MED12L	2006	Q86YW9
QRLNHQALQQSPLVG	MED12L	2011	Q86YW9
LSGNHRLQHINLQGN	NLRC3	1026	Q7RTR2
LLPLHQLRGSNTQPN	MGA	1811	Q8IWI9
NPNNILLNDRGHIQL	RPS6KC1	931	Q96S38
APGHSRQLLLQLNNQ	HIC1	26	Q14526
LPGEHQQVLSNLQSR	DST	1001	Q03001
LNQQLTNHIRDTLPG	DNM1	281	Q05193
GLNSPNHAIIQNLIN	BMP15	331	O95972
LNPVANFHLQNGAVL	MLYCD	416	O95822
HNLGINNNNILQPVD	MACO1	266	Q8N5G2
LPENLRALHLQNNNI	EPYC	256	Q99645
RLNLLHSQNTGLLNQ	MYH7B	1761	A7E2Y1
EFLLLGLSRQPQQQH	OR1F1	11	O43749
EFLLLGLSRQPQQQH	OR1F2P	11	Q96R84
LHLLQAAAQALNPLG	PPCS	156	Q9HAB8
SNDPGQLLRNHLNQV	OTULIN	266	Q96BN8
GPVANLRHNLNNVIA	DCST1	131	Q5T197
NLTLQEHLRQAQPGS	CEP85	646	Q6P2H3
PSNNHQLQLAGALAI	RAP1GDS1	326	P52306
SHNQLQSLPLLGQTL	GP1BA	101	P07359
GLLGMPLNQILNQHN	MBD5	556	Q9P267
LNLRQGYNLEPQLQH	INSRR	356	P14616
GNLPAVHRLVNLFQQ	BCL3	146	P20749
QQQRLRQPNLAQLGH	MN1	566	Q10571
PHQQHLSLQLGELRQ	MAP3K15	1171	Q6ZN16
NQLLGNHRTPQLVSE	RPGR	226	Q92834
AQPNQGSLVNQNLLH	FOXO3	521	O43524
PGQINLAQLRLQHMQ	TRIM33	506	Q9UPN9
LSPGLFHNNHNLQRL	LRRC15	236	Q8TF66
VELNLQNPSLNHQGI	KLRC2	41	P26717
CNNILRNHQHGLPQR	PLCE1	106	Q9P212
QNQLRSPAIGLNNLD	IQGAP2	391	Q13576
QQLAGLPRSQQQRHL	RUFY4	231	Q6ZNE9
PNNQQQLLRKRHIGN	SIPA1	416	Q96FS4
AGLNQVNNQGLTPLH	PLA2G6	211	O60733
LLNNANPNLSNRRGS	RIPK4	506	P57078
SLLAQFRNLGQNEPH	SMAD1	151	Q15797
EHLQLQNLGINPANI	CLTC	11	Q00610
TVHLANLNLLPQGAQ	ZNF532	521	Q9HCE3
LQRHQQQLLASPGSS	XPO4	511	Q9C0E2
NGVNALQLDPALNRL	WDR48	31	Q8TAF3
LQLHPQHNRALFNLG	TMTC1	541	Q8IUR5
DAQAQRRLQLLQNGP	ZFHX2	896	Q9C0A1
LKNPRNSHLQQNLLS	TCEANC	231	Q8N8B7
GPSNIAKQLNNRVNH	REV1	156	Q9UBZ9
LSANNLQHLGPRIFQ	TRIL	236	Q7L0X0
KPLFGALQNRQHNGL	UBR1	1341	Q8IWV7
NGNLHLLNPSNSARL	TENM3	2156	Q9P273
GILSQRGIHLNNNLN	USP31	406	Q70CQ4
LSLINQKRRHGINNP	ZNF614	141	Q8N883
NRLLLTGTPLQNNLH	SMARCA5	331	O60264
LVACNPNLQLLQGHR	TKFC	21	Q3LXA3
AGLQPTNLGRNNSLH	TRRAP	2951	Q9Y4A5
GQLQLAQDHSSLNPQ	USP44	11	Q9H0E7
NNQCLLGANGNILLH	USP32	501	Q8NFA0
LRPKNLGLAHQRQQQ	ZNF337	91	Q9Y3M9
PGNHVQLRGNLANSN	TRERF1	91	Q96PN7
RLPGQQQQQVSLLHT	KMT2D	4096	O14686
LQHLIVNNNQLGGIA	LRFN2	126	Q9ULH4
NPNLRSLDLGNNDLQ	NLRP14	956	Q86W24
QQQLNGLISPELRHL	NAA30	81	Q147X3