Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmedium-chain fatty acid omega-hydroxylase activity

CYP4A11 CYP4A22

2.33e-062312GO:0140981
GeneOntologyMolecularFunction16-hydroxypalmitate dehydrogenase activity

CYP4A11 CYP4A22

2.33e-062312GO:0103002
GeneOntologyMolecularFunctionvascular endothelial growth factor binding

KDR NRP1

3.49e-056312GO:0038085
GeneOntologyMolecularFunctionleukotriene-B4 20-monooxygenase activity

CYP4A11 CYP4A22

4.87e-057312GO:0050051
GeneOntologyMolecularFunctionvascular endothelial growth factor receptor activity

KDR NRP1

4.87e-057312GO:0005021
GeneOntologyMolecularFunctionalkane 1-monooxygenase activity

CYP4A11 CYP4A22

4.87e-057312GO:0018685
GeneOntologyMolecularFunctionarachidonate omega-hydroxylase activity

CYP4A11 CYP4A22

1.04e-0410312GO:0052869
GeneOntologyMolecularFunctionfatty acid omega-hydroxylase activity

CYP4A11 CYP4A22

1.04e-0410312GO:0120250
GeneOntologyMolecularFunctionlong-chain fatty acid omega-hydroxylase activity

CYP4A11 CYP4A22

1.04e-0410312GO:0102033
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

CYP4A11 CYP4A22

1.80e-0413312GO:0016713
GeneOntologyMolecularFunctionarachidonate binding

CYP4A11 CYP4A22

2.42e-0415312GO:0050544
GeneOntologyMolecularFunctionicosanoid binding

CYP4A11 CYP4A22

2.76e-0416312GO:0050542
GeneOntologyMolecularFunctionicosatetraenoic acid binding

CYP4A11 CYP4A22

2.76e-0416312GO:0050543
GeneOntologyMolecularFunctionarachidonate epoxygenase activity

CYP4A11 CYP4A22

6.30e-0424312GO:0008392
GeneOntologyMolecularFunctionarachidonate monooxygenase activity

CYP4A11 CYP4A22

7.99e-0427312GO:0008391
GeneOntologyMolecularFunctionlong-chain fatty acid binding

CYP4A11 CYP4A22

8.60e-0428312GO:0036041
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

KCNAB1 CYP4A11 CYP4A22

9.92e-04127313GO:0016616
GeneOntologyMolecularFunctionligand-gated calcium channel activity

GRIN1 TPCN1

1.05e-0331312GO:0099604
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH-OH group of donors

KCNAB1 CYP4A11 CYP4A22

1.26e-03138313GO:0016614
GeneOntologyMolecularFunctionaromatase activity

CYP4A11 CYP4A22

1.34e-0335312GO:0070330
GeneOntologyMolecularFunctiongated channel activity

KCNAB1 GRIN1 TMC3 TPCN1

1.69e-03334314GO:0022836
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP4A11 CYP4A22

2.62e-0349312GO:0016712
GeneOntologyMolecularFunctionvoltage-gated channel activity

KCNAB1 GRIN1 TPCN1

2.86e-03184313GO:0022832
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

KDR NRP1

4.57e-0365312GO:0004714
GeneOntologyMolecularFunctionfatty acid binding

CYP4A11 CYP4A22

5.13e-0369312GO:0005504
GeneOntologyMolecularFunctionmonoatomic ion channel activity

KCNAB1 GRIN1 TMC3 TPCN1

5.30e-03459314GO:0005216
GeneOntologyMolecularFunctioncoreceptor activity

KDR NRP1

5.57e-0372312GO:0015026
GeneOntologyMolecularFunctionamino acid binding

GRIN1 HDC

5.72e-0373312GO:0016597
GeneOntologyMolecularFunctioncarboxylic acid binding

GRIN1 CYP4A11 CYP4A22

5.94e-03239313GO:0031406
GeneOntologyMolecularFunctionorganic acid binding

GRIN1 CYP4A11 CYP4A22

7.03e-03254313GO:0043177
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

KDR NRP1

7.69e-0385312GO:0019199
GeneOntologyMolecularFunctionchannel activity

KCNAB1 GRIN1 TMC3 TPCN1

8.47e-03525314GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

KCNAB1 GRIN1 TMC3 TPCN1

8.52e-03526314GO:0022803
GeneOntologyBiologicalProcesslauric acid metabolic process

CYP4A11 CYP4A22

6.55e-063312GO:0048252
GeneOntologyCellularComponentsorting endosome

KDR NRP1

3.18e-056312GO:0097443
GeneOntologyCellularComponentcell body

KCNAB1 KDR GRIN1 CYFIP1 P2RY1 GNB5 HDC NRP1

4.67e-05929318GO:0044297
GeneOntologyCellularComponentsomatodendritic compartment

KCNAB1 KDR GRIN1 CYFIP1 P2RY1 GNB5 HDC NRP1

3.25e-041228318GO:0036477
GeneOntologyCellularComponentexcitatory synapse

GRIN1 CYFIP1 GNB5

5.28e-04107313GO:0060076
GeneOntologyCellularComponentneuronal cell body

KCNAB1 KDR GRIN1 CYFIP1 HDC NRP1

1.25e-03835316GO:0043025
GeneOntologyCellularComponentdendrite

KCNAB1 GRIN1 CYFIP1 P2RY1 GNB5 HDC

1.43e-03858316GO:0030425
GeneOntologyCellularComponentdendritic tree

KCNAB1 GRIN1 CYFIP1 P2RY1 GNB5 HDC

1.45e-03860316GO:0097447
GeneOntologyCellularComponentparallel fiber to Purkinje cell synapse

GRIN1 GNB5

1.85e-0343312GO:0098688
MousePhenoincreased renal vascular resistance

CYP4A11 CYP4A22

3.06e-055252MP:0005531
MousePhenoabnormal renal sodium reabsorption

CYP4A11 CYP4A22

3.06e-055252MP:0010109
MousePhenoabnormal renal vascular resistance

CYP4A11 CYP4A22

8.54e-058252MP:0005529
MousePhenoabnormal renal sodium ion transport

CYP4A11 CYP4A22

8.54e-058252MP:0011442
MousePhenosalt-sensitive hypertension

CYP4A11 CYP4A22

1.37e-0410252MP:0004217
MousePhenoabnormal body water content

CYP4A11 CYP4A22

2.00e-0412252MP:0000676
DomainAllrgn_V5/Tpx1_CS

CRISP1 PI15

1.19e-0410312IPR018244
DomainCRISP_1

CRISP1 PI15

1.45e-0411312PS01009
DomainCRISP_2

CRISP1 PI15

1.45e-0411312PS01010
Domain-

CRISP1 PI15

2.76e-04153123.40.33.10
DomainCAP

CRISP1 PI15

2.76e-0415312PF00188
DomainCAP_domain

CRISP1 PI15

2.76e-0415312IPR014044
DomainSCP

CRISP1 PI15

2.76e-0415312SM00198
DomainAllrgn_V5/Tpx1

CRISP1 PI15

2.76e-0415312IPR001283
DomainCyt_P450_E_grp-I

CYP4A11 CYP4A22

2.52e-0345312IPR002401
DomainCUB

ATRN NRP1

2.99e-0349312PF00431
DomainCUB

ATRN NRP1

3.11e-0350312SM00042
Domain-

ATRN NRP1

3.36e-03523122.60.120.290
DomainCUB

ATRN NRP1

3.49e-0353312PS01180
DomainCyt_P450_CS

CYP4A11 CYP4A22

3.49e-0353312IPR017972
DomainCYTOCHROME_P450

CYP4A11 CYP4A22

4.02e-0357312PS00086
DomainCUB_dom

ATRN NRP1

4.02e-0357312IPR000859
Domain-

CYP4A11 CYP4A22

4.16e-03583121.10.630.10
Domainp450

CYP4A11 CYP4A22

4.16e-0358312PF00067
DomainCyt_P450

CYP4A11 CYP4A22

4.44e-0360312IPR001128
DomainWD40

IFT172 DMXL1 GNB5

8.90e-03259313PF00400
DomainWD40

IFT172 DMXL1 GNB5

9.76e-03268313SM00320
DomainWD40_repeat

IFT172 DMXL1 GNB5

1.02e-02272313IPR001680
DomainWD_REPEATS_1

IFT172 DMXL1 GNB5

1.08e-02278313PS00678
DomainWD_REPEATS_2

IFT172 DMXL1 GNB5

1.09e-02279313PS50082
DomainWD_REPEATS_REGION

IFT172 DMXL1 GNB5

1.09e-02279313PS50294
DomainWD40_repeat_dom

IFT172 DMXL1 GNB5

1.29e-02297313IPR017986
Domain-

IFT172 DMXL1 GNB5

1.75e-023333132.130.10.10
DomainWD40/YVTN_repeat-like_dom

IFT172 DMXL1 GNB5

1.77e-02335313IPR015943
DomainPkinase_Tyr

KDR TEX14

1.93e-02129312PF07714
PathwayWP_SARSCOV2_ALTERING_ANGIOGENESIS_VIA_NRP1

KDR NRP1

2.11e-055212M42561
PathwayWP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES_PATHWAY

CYP4A11 CYP4A22

7.56e-059212M39819
PathwayPID_VEGF_VEGFR_PATHWAY

KDR NRP1

9.44e-0510212M137
PathwayREACTOME_SYNTHESIS_OF_16_20_HYDROXYEICOSATETRAENOIC_ACIDS_HETE

CYP4A11 CYP4A22

1.15e-0411212MM14863
PathwayREACTOME_EICOSANOIDS

CYP4A11 CYP4A22

1.38e-0412212M27129
PathwayREACTOME_MISCELLANEOUS_SUBSTRATES

CYP4A11 CYP4A22

1.38e-0412212M27128
PathwayREACTOME_EICOSANOIDS

CYP4A11 CYP4A22

1.38e-0412212MM14845
PathwayKEGG_PPAR_SIGNALING_PATHWAY

CYP4A11 LPL CYP4A22

1.40e-0469213M13088
PathwayWP_PPAR_SIGNALING_PATHWAY

CYP4A11 LPL CYP4A22

1.66e-0473213MM15995
PathwayWP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES

CYP4A11 CYP4A22

1.90e-0414212MM15842
PathwayREACTOME_FATTY_ACIDS

CYP4A11 CYP4A22

2.19e-0415212M27126
PathwayREACTOME_MISCELLANEOUS_SUBSTRATES

CYP4A11 CYP4A22

3.19e-0418212MM14843
PathwayREACTOME_FATTY_ACIDS

CYP4A11 CYP4A22

3.19e-0418212MM14841
PathwayREACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX

CYP4A11 CYP4A22

4.36e-0421212M27137
PathwayREACTOME_SIGNALING_BY_VEGF

KDR CYFIP1 NRP1

4.58e-04103213MM14752
PathwayREACTOME_SIGNALING_BY_VEGF

KDR CYFIP1 NRP1

4.98e-04106213M27077
PathwayREACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_1

P2RY1 GNB5

6.21e-0425212MM15056
PathwayREACTOME_ADP_SIGNALLING_THROUGH_P2Y_PURINOCEPTOR_1

P2RY1 GNB5

6.21e-0425212M811
PathwayREACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX

CYP4A11 CYP4A22

6.21e-0425212MM14858
PathwayWP_CELL_INTERACTIONS_OF_THE_PANCREATIC_CANCER_MICROENVIRONMENT

KDR NRP1

6.72e-0426212M46461
PathwayWP_EICOSANOID_METABOLISM_VIA_LIPOOXYGENASES_LOX

CYP4A11 CYP4A22

8.38e-0429212M39858
PathwayWP_EICOSANOID_METABOLISM_VIA_CYCLOOXYGENASES_COX

CYP4A11 CYP4A22

9.58e-0431212M39851
PathwayBIOCARTA_NUCLEARRS_PATHWAY

CYP4A11 CYP4A22

1.09e-0333212MM1448
PathwayWP_DISRUPTION_OF_POSTSYNAPTIC_SIGNALING_BY_CNV

GRIN1 CYFIP1

1.09e-0333212M39875
PathwayREACTOME_SIGNAL_AMPLIFICATION

P2RY1 GNB5

1.09e-0333212MM15020
PathwayWP_EICOSANOID_METABOLISM_VIA_CYCLOOXYGENASES_COX

CYP4A11 CYP4A22

1.09e-0333212MM15918
PathwayWP_EICOSANOID_METABOLISM_VIA_LIPOXYGENASES_LOX

CYP4A11 CYP4A22

1.09e-0333212MM15963
PathwayREACTOME_SIGNAL_AMPLIFICATION

P2RY1 GNB5

1.09e-0333212M9379
PathwayBIOCARTA_NUCLEARRS_PATHWAY

CYP4A11 CYP4A22

1.15e-0334212M16393
PathwayKEGG_FATTY_ACID_METABOLISM

CYP4A11 CYP4A22

1.76e-0342212M699
PathwayWP_RAS_SIGNALING

KDR GRIN1 GNB5

2.45e-03184213M39764
PathwayREACTOME_SENSORY_PERCEPTION

OR4L1 LPL GNB5

2.68e-03190213MM15687
PathwayWP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER

KDR NRP1

2.89e-0354212M42568
Pubmed

Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension.

CYP4A11 CYP4A22

7.69e-07231215611369
Pubmed

20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertension.

CYP4A11 CYP4A22

7.69e-07231223825080
Pubmed

Vascular endothelial growth factor receptor-2 and neuropilin-1 form a receptor complex that is responsible for the differential signaling potency of VEGF(165) and VEGF(121).

KDR NRP1

7.69e-07231211333271
Pubmed

Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.

CYP4A11 CYP4A22

7.69e-07231216691295
Pubmed

The P450 gene superfamily: recommended nomenclature.

CYP4A11 CYP4A22

7.69e-0723123829886
Pubmed

Role of the NRP-1-mediated VEGFR2-independent pathway on radiation sensitivity of non-small cell lung cancer cells.

KDR NRP1

7.69e-07231229777301
Pubmed

VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival.

KDR NRP1

7.69e-07231230027561
Pubmed

Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice.

CYP4A11 CYP4A22

7.69e-07231229277328
Pubmed

Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population.

CYP4A11 CYP4A22

7.69e-07231221820496
Pubmed

Neuropilin-1 expression promotes invasiveness of melanoma cells through vascular endothelial growth factor receptor-2-dependent and -independent mechanisms.

KDR NRP1

7.69e-07231223685409
Pubmed

Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase.

CYP4A11 CYP4A22

7.69e-07231223641057
Pubmed

Renal function and vasomotor activity in mice lacking the Cyp4a14 gene.

CYP4A11 CYP4A22

7.69e-07231220943934
Pubmed

The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis.

CYP4A11 CYP4A22

7.69e-07231228912346
Pubmed

Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes.

CYP4A11 CYP4A22

7.69e-07231224413902
Pubmed

Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family.

KDR NRP1

7.69e-07231211166270
Pubmed

Interactions between NRP1 and VEGFR2 molecules in the plasma membrane.

KDR NRP1

7.69e-07231229630862
Pubmed

The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes.

CYP4A11 CYP4A22

7.69e-0723122766933
Pubmed

Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hormonal regulation in liver and kidney.

CYP4A11 CYP4A22

7.69e-0723128031839
Pubmed

Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein.

CYP4A11 CYP4A22

7.69e-07231210860550
Pubmed

Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth.

KDR NRP1

7.69e-07231222393126
Pubmed

Neuropilin-1-VEGFR-2 complexing requires the PDZ-binding domain of neuropilin-1.

KDR NRP1

7.69e-07231218628209
Pubmed

Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation.

CYP4A11 CYP4A22

7.69e-07231217112342
Pubmed

Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.

CYP4A11 CYP4A22

7.69e-07231211320253
Pubmed

Neuropilin-1 forms complexes with vascular endothelial growth factor receptor-2 during megakaryocytic differentiation of UT-7/TPO cells.

KDR NRP1

7.69e-07231219857463
Pubmed

Characterization of the CYP4A11 gene, a second CYP4A gene in humans.

CYP4A11 CYP4A22

7.69e-07231212464262
Pubmed

VEGFR2 trafficking: speed doesn't kill.

KDR NRP1

7.69e-07231223803732
Pubmed

Microenvironment drives the endothelial or neural fate of differentiating embryonic stem cells coexpressing neuropilin-1 and Flk-1.

KDR NRP1

7.69e-07231218757501
Pubmed

High-fat diet-induced obesity and insulin resistance in CYP4a14-/- mice is mediated by 20-HETE.

CYP4A11 CYP4A22

7.69e-07231230088983
Pubmed

Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta.

CYP4A11 CYP4A22

7.69e-07231215066132
Pubmed

VEGF165 mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor binding.

KDR NRP1

7.69e-07231211948691
Pubmed

Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2.

KDR NRP1

7.69e-07231215522955
Pubmed

Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases.

CYP4A11 CYP4A22

7.69e-07231219208908
Pubmed

Differential expression of VEGF isoforms and VEGF(164)-specific receptor neuropilin-1 in the mouse uterus suggests a role for VEGF(164) in vascular permeability and angiogenesis during implantation.

KDR NRP1

2.31e-06331210705382
Pubmed

Genetic analysis of resistance to radiation lymphomagenesis with recombinant inbred strains of mice.

CYP4A11 CYP4A22

2.31e-0633122354437
Pubmed

Expression and regulation of vascular endothelial growth factor ligands and receptors during menstruation and post-menstrual repair of human endometrium.

KDR NRP1

2.31e-06331216648151
Pubmed

Distinct heparin binding sites on VEGF165 and its receptors revealed by their interaction with a non sulfated glycoaminoglycan (NaPaC).

KDR NRP1

2.31e-06331218325345
Pubmed

Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output.

KDR NRP1

2.31e-06331221586748
Pubmed

Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization.

CYP4A11 CYP4A22

2.31e-0633128011168
Pubmed

Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells.

KDR NRP1

2.31e-06331218223683
Pubmed

Heparin binding VEGF isoforms attenuate hyperoxic embryonic lung growth retardation via a FLK1-neuropilin-1-PKC dependent pathway.

KDR NRP1

2.31e-06331224641672
Pubmed

Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling.

KDR NRP1

2.31e-06331216763549
Pubmed

NRP1 interacts with endoglin and VEGFR2 to modulate VEGF signaling and endothelial cell sprouting.

KDR NRP1

2.31e-06331238242992
Pubmed

Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.

CYP4A11 CYP4A22

2.31e-06331228270609
Pubmed

Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting.

KDR NRP1

2.31e-06331217575273
Pubmed

Raftlin is recruited by neuropilin-1 to the activated VEGFR2 complex to control proangiogenic signaling.

KDR NRP1

2.31e-06331232274611
Pubmed

The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.

CYP4A11 CYP4A22

2.31e-0633121991046
Pubmed

Characterization of a bicyclic peptide neuropilin-1 (NP-1) antagonist (EG3287) reveals importance of vascular endothelial growth factor exon 8 for NP-1 binding and role of NP-1 in KDR signaling.

KDR NRP1

2.31e-06331216513643
Pubmed

Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells.

KDR NRP1

2.31e-06331238324585
Pubmed

A peptide competing with VEGF165 binding on neuropilin-1 mediates targeting of a chlorin-type photosensitizer and potentiates its photodynamic activity in human endothelial cells.

KDR NRP1

2.31e-06331216423422
Pubmed

Neuropilin-1 regulates vascular endothelial growth factor-mediated endothelial permeability.

KDR NRP1

2.31e-06331215920019
Pubmed

Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth.

KDR NRP1

2.31e-06331217222790
Pubmed

Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice.

CYP4A11 CYP4A22

2.31e-06331219713718
Pubmed

Peroxisome proliferator activated receptor alpha regulates a male-specific cytochrome P450 in mouse liver.

CYP4A11 CYP4A22

2.31e-06331215313227
Pubmed

H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on liver in the treatment of Schistosoma japonicum infection.

CYP4A11 CYP4A22

2.31e-06331237659685
Pubmed

Enhancement of vascular progenitor potential by protein kinase A through dual induction of Flk-1 and Neuropilin-1.

KDR NRP1

2.31e-06331219706882
Pubmed

Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding.

KDR NRP1

2.31e-06331225244320
Pubmed

Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis.

KDR NRP1

2.31e-06331211756651
Pubmed

A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans.

CYP4A11 CYP4A22

2.31e-0633129271096
Pubmed

VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling.

KDR TPCN1

4.61e-06431225331892
Pubmed

VEGF receptors and neuropilins are expressed in the urothelial and neuronal cells in normal mouse urinary bladder and are upregulated in inflammation.

KDR NRP1

4.61e-06431218463314
Pubmed

VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation.

KDR NRP1

4.61e-06431228289053
Pubmed

Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal.

CYP4A11 CYP4A22

4.61e-0643128334987
Pubmed

Mapping of the azh locus to mouse chromosome 4.

CYP4A11 CYP4A22

4.61e-0643121552159
Pubmed

The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1.

KDR NRP1

4.61e-06431210842181
Pubmed

VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation.

KDR NRP1

4.61e-06431221653826
Pubmed

Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats.

CYP4A11 CYP4A22

4.61e-06431210049703
Pubmed

Snake venom vascular endothelial growth factors (VEGFs) exhibit potent activity through their specific recognition of KDR (VEGF receptor 2).

KDR NRP1

4.61e-06431214600159
Pubmed

Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma.

KDR NRP1

4.61e-06431211807987
Pubmed

Increased expression of VEGF-receptors (FLT-1, KDR, NRP-1) and thrombospondin-1 is associated with glomeruloid microvascular proliferation, an aggressive angiogenic phenotype, in malignant melanoma.

KDR NRP1

4.61e-06431215166498
Pubmed

Synergistic Binding of Vascular Endothelial Growth Factor-A and Its Receptors to Heparin Selectively Modulates Complex Affinity.

KDR NRP1

4.61e-06431225979342
Pubmed

Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice.

CYP4A11 CYP4A22

4.61e-06431222159897
Pubmed

The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis.

KDR NRP1

4.61e-06431223639442
Pubmed

Gain of affinity for VEGF165 binding within the VEGFR2/NRP1 cellular complex detected by an HTRF-based binding assay.

KDR NRP1

4.61e-06431230236477
Pubmed

Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase.

CYP4A11 CYP4A22

4.61e-06431221161333
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

ATRN TMEM259 PLBD2 ALG12 LPL DMXL1 NRP1 TPCN1

7.67e-06120131835696571
Pubmed

Ontogeny of semaphorins 3A and 3F and their receptors neuropilins 1 and 2 in the kidney.

KDR NRP1

7.68e-06531214516677
Pubmed

Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells.

KDR NRP1

7.68e-06531224863063
Pubmed

Vascular endothelial growth factor regulates stanniocalcin-1 expression via neuropilin-1-dependent regulation of KDR and synergism with fibroblast growth factor-2.

KDR NRP1

7.68e-06531218164591
Pubmed

Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs.

CYP4A11 CYP4A22

7.68e-0653128363569
Pubmed

Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis.

KDR NRP1

7.68e-06531219837659
Pubmed

Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165.

KDR NRP1

7.68e-06531211886873
Pubmed

Immunolocalization and expression of vascular endothelial growth factor receptors (VEGFRs) and neuropilins (NRPs) on keratinocytes in human epidermis.

KDR NRP1

7.68e-06531217088944
Pubmed

Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signaling.

KDR NRP1

7.68e-06531222897854
Pubmed

Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas.

KDR NRP1

7.68e-06531224791743
Pubmed

Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase.

CYP4A11 CYP4A22

7.68e-06531220427718
Pubmed

Mapping of guanylin to murine chromosome 4 and human chromosome 1p34-p35.

CYP4A11 CYP4A22

7.68e-0653127601480
Pubmed

Organization of the distal end of mouse chromosome 4.

CYP4A11 CYP4A22

1.15e-0563123166417
Pubmed

Peroxisome proliferator-activated receptor-α accelerates α-chlorofatty acid catabolism.

CYP4A11 CYP4A22

1.15e-05631228007964
Pubmed

NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis.

KDR NRP1

1.15e-05631223315162
Pubmed

Peroxisome proliferator-activated receptor alpha-responsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidase null mice.

CYP4A11 CYP4A22

1.15e-05631211461119
Pubmed

Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells.

CYP4A11 CYP4A22

1.15e-0563128798505
Pubmed

Mouse uroporphyrinogen decarboxylase: cDNA cloning, expression, and mapping.

CYP4A11 CYP4A22

1.15e-0563128661721
Pubmed

Exploratory study evaluating the association of polymorphisms of angiogenesis genes with hot flashes.

KDR NRP1

1.15e-05631218785001
Pubmed

Genetic association of angiogenesis- and hypoxia-related gene polymorphisms with osteonecrosis of the femoral head.

KDR NRP1

1.15e-05631220215856
Pubmed

Transcriptional activation of placental growth factor by the forkhead/winged helix transcription factor FoxD1.

KDR NRP1

1.61e-05731213678594
Pubmed

Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity.

CYP4A11 CYP4A22

1.61e-05731212958197
Pubmed

VEGF expression and receptor activation in the choroid during development and in the adult.

KDR NRP1

1.61e-05731216799060
Pubmed

Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors.

CYP4A11 CYP4A22

1.61e-05731218648086
Pubmed

Association of polymorphisms of angiogenesis genes with breast cancer.

KDR NRP1

1.61e-05731217891484
Pubmed

Fenestral diaphragms and PLVAP associations in liver sinusoidal endothelial cells are developmentally regulated.

KDR NRP1

1.61e-05731231666588
InteractionCYP4A22 interactions

CYP4A11 CYP4A22

6.86e-063312int:CYP4A22
InteractionCYP4A11 interactions

CYP4A11 CYP4A22

2.28e-055312int:CYP4A11
Cytoband12q24.13

PLBD2 TPCN1

1.31e-042531212q24.13
Cytoband1p33

CYP4A11 CYP4A22

2.59e-04353121p33
CytobandEnsembl 112 genes in cytogenetic band chr1p33

CYP4A11 CYP4A22

7.88e-0461312chr1p33
CytobandEnsembl 112 genes in cytogenetic band chr15q21

GNB5 HDC

6.39e-03177312chr15q21
CytobandEnsembl 112 genes in cytogenetic band chr3q25

KCNAB1 P2RY1

6.60e-03180312chr3q25
Cytoband14q11.2

IL25 OR4L1

6.60e-0318031214q11.2
GeneFamilyCytochrome P450 family 4

CYP4A11 CYP4A22

8.68e-04362221003
GeneFamilyWD repeat domain containing

IFT172 DMXL1 GNB5

3.78e-03262223362
ToppCellE17.5-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell_of_alveolus|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KDR TEX14 IFT172 NRP1

5.99e-06178304982205ba117a4c7b7e9b713689a5b69190f0bca9
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CYFIP1 P2RY1 PLBD2 LPL

6.98e-061853047bff05d8d34616adbaa0ea0b69eb30aa906bb9f8
ToppCellfacs-Heart-LA-18m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL HDC NRP1

7.28e-06187304b0768a0102d533bc6c9efe56b7a9c18db7a374b7
ToppCellfacs-Heart-LA-18m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL HDC NRP1

7.28e-0618730487d4323a72e96ce35f9981faa92ded846a474384
ToppCellBL-critical-LOC-Myeloid-Macrophage|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CYFIP1 PLBD2 LPL NRP1

9.49e-06200304dc3d5af1d4b15cc258d456f9f450550874456299
ToppCell3'_v3-bone_marrow-Lymphocytic_T_CD4-Trm_Th1/Th17|bone_marrow / Manually curated celltypes from each tissue

B3GALT2 RADIL TNFAIP3

1.35e-04149303264fe2ceac6379b3394d2bb47ef34692e4a64559
ToppCellfacs-Marrow-T-cells-24m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RADIL P2RY1 HDC

1.58e-04157303ed9c9feefc06c9536c03bedbc3397a2ee492a78e
ToppCellfacs-Marrow-T-cells-24m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RADIL P2RY1 HDC

1.58e-04157303fddcb24776b9f86e000208bae54541b15b2adefd
ToppCell356C-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

P2RY1 LPL NRP1

1.67e-041603030293b244c063a62819690bf22bbc2681f8d15252
ToppCell356C-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

P2RY1 LPL NRP1

1.67e-041603033eaae86fa08f7651021316f8e5811bf48055591e
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

1.73e-04162303465cb483f41023d6125ea147e16f404d8e8dc9bb
ToppCell10x3'2.3-week_14-16-Myeloid_macrophage-stroma-erythroid_macrophage|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

KCNAB1 PI15 NRP1

1.76e-04163303240d9f0ea45e8b2c7173e7674fd740555810f9e7
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KDR GNB5 NRP1

1.93e-04168303c7021748003e5949f7caf7b3291c5bad294948c1
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KDR TEX14 NRP1

1.96e-0416930341ad349806b279fbe1374b7e3cc7f146a11adb44
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KDR TEX14 NRP1

1.96e-0416930342782c61592742190ab0cba8a94f8bdf9c278f90
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNFAIP3 PI15 NRP1

2.03e-041713038719a18c9e6b6f5d8ec4e937c2bda1e36441c9ec
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-BM_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNFAIP3 PI15 NRP1

2.03e-04171303f4cdd7862c8fe99ee765a2f3ed375b584f4976c5
ToppCelldroplet-Kidney-nan-3m-Epithelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B3GALT2 KDR P2RY1

2.07e-04172303073a503dc922e3e3ac3528e249b0f8b74402110b
ToppCelldroplet-Liver-Npc-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR HDC NRP1

2.07e-04172303a6fb1bde8d942c7b5caaf7bd14de0b7ce32fda55
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TEX14 P2RY1 HDC

2.10e-041733033612772632ddf11eb48579cae9a8ccab6b3f1f52
ToppCelldroplet-Lung-3m-Hematologic-myeloid-Basophil/Mast_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TNFAIP3 P2RY1 HDC

2.10e-04173303b2c55084ef6dac0e329c2e65c24cfe0045859c30
ToppCelldroplet-Lung-immune-endo-depleted-3m-Myeloid-Basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TEX14 P2RY1 HDC

2.10e-041733034dc261ebcdb9bdcfca1451da1bd254f0dc5de203
ToppCelldroplet-Lung-3m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TNFAIP3 P2RY1 HDC

2.10e-04173303120dd20e8a71f9169a1596b6171df7aa0b96dd15
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

B3GALT2 TMC3 NRP1

2.10e-0417330395c723b09254ae7131fe5ba0841472502e83269b
ToppCellfacs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KDR LPL NRP1

2.14e-04174303b1bcd5f4505d2ccef4183fcfbf1de81964b3f9e0
ToppCelldroplet-Liver-Npc-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR HDC NRP1

2.21e-041763033494ffa8555e6edf4b1250e10434bae9b73ec845
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

B3GALT2 TMC3 NRP1

2.21e-0417630372a2a01618ce836bc843395d5095e9090759b4a6
ToppCelldroplet-Liver-Npc-18m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR HDC NRP1

2.21e-04176303d43f6b7828b98e1dab7b726a5f99499d65a7db80
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L5-6_FEZF2_ANKRD20A1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

B3GALT2 TMC3 NRP1

2.25e-04177303f63b62bb2be737f2d26be16943487ec27bf3bcd4
ToppCellfacs-Marrow-T-cells-3m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNFAIP3 P2RY1 HDC

2.29e-0417830341745a589567ca5ea6d06331f4c8da03595b5f5c
ToppCell5'-Adult-LymphNode-Endothelial-blood_vessel_EC-arterial_capillary|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KDR LPL NRP1

2.29e-04178303360d7a987f91d6d721487a921824057ec31a7332
ToppCellfacs-Marrow-T-cells-3m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNFAIP3 P2RY1 HDC

2.29e-04178303eb940dd64c973f68bcaad6069d3bd56383329db5
ToppCellfacs-Heart-RV-24m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

2.32e-04179303cf4d3828a3ce97932c68d06f5c65a070fc6d832c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CYP4A11 CYP4A22 TPCN1

2.32e-0417930378fae47ec9bff4e0159a86a281e831d7f8ee925a
ToppCell3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

B3GALT2 KDR RADIL

2.32e-04179303ec1d7017da325647b629de703135a404bbdc627d
ToppCellfacs-Heart-RV-24m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

2.32e-041793036aa211670e5d6e013d0980967aa0a4f8f2905efe
ToppCellfacs-Heart-RV-24m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

2.32e-04179303f9bc76ff25f88ee44c72499a0df9dc16f519c4cb
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

B3GALT2 TMC3 NRP1

2.32e-04179303f65889bf1e41396979cce44a5e63f49dea2bbd9b
ToppCelldroplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR HDC NRP1

2.40e-04181303a53f05c4c47465ee62e353716456bd09ab464b23
ToppCellfacs-Marrow-T-cells-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNFAIP3 P2RY1 NRP1

2.40e-041813037286700396676fdc41d9723979b8b408177aceb9
ToppCellfacs-Kidney-nan-3m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATRN KDR NRP1

2.44e-041823034c5d14e33ebdf117b5aa9e2f57aaa89aa51f72bf
ToppCelldroplet-Kidney-nan-3m-Endothelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR P2RY1 NRP1

2.44e-04182303f4a5f1c3a04c0566eb96607dab7a0d9a5ebc3fd1
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

2.44e-04182303506b63a233baf5e3baf924c13c88ab283b6e894f
ToppCelldroplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR HDC NRP1

2.48e-04183303709a486154b3157427deb3b8886b63ac39ea42dd
ToppCelldroplet-Liver-nan-3m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR HDC NRP1

2.48e-04183303dc06f19f6f80f4c7f13f1f990c1fe0f91ba64ea7
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Monocytic-Nonclassical_Monocyte|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KCNAB1 PLBD2 LPL

2.48e-041833034cc0961a67de76b8d756cd9ffcaa98e3fe3c3a69
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

B3GALT2 TMC3 NRP1

2.48e-0418330365f2a5895d166189a095cf7ea9dda171f0419b08
ToppCelldroplet-Kidney-nan-21m-Epithelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

B3GALT2 KDR P2RY1

2.48e-04183303f55081068213cc1cdb2acad58ff10f6b48b44c72
ToppCellPND14|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TEX14 PI15 NRP1

2.52e-041843031bfee4eb121e76a79f48b06b45f05d124fbbedba
ToppCelldroplet-Liver-HEPATOCYTES-1m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR P2RY1 HDC

2.56e-04185303742350093d90f96735dc73e3360cdd749bae63fd
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATRN NRP1 TPCN1

2.56e-041853038207f9eff113eed429e961748c6b17d672a13b33
ToppCellfacs-Thymus-Epithelium-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P2RY1 PI15 LPL

2.56e-04185303eaa54b76743628c89b4310be57b87fa92b75fd37
ToppCellfacs-Thymus-Epithelium-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P2RY1 PI15 LPL

2.56e-04185303f7f4c921d248c637351e2e882589b99ba7f04b66
ToppCellfacs-Thymus-Epithelium-24m-Mesenchymal|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P2RY1 PI15 LPL

2.56e-04185303ff38a15af3dec36d9993f06623591872b5d1da9a
ToppCellfacs-Heart-RV|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

2.56e-041853037cf2b0db059605032bfae60cf1b93c4c62608f0c
ToppCellfacs-Lung-Endomucin-3m-Endothelial-Capillary_Aerocyte_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR TEX14 NRP1

2.60e-041863039d6cb36aa0aae69fe584dad31deafcfdcc9fd1db
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCNAB1 PI15 CYP4A11

2.64e-04187303d52f7bc0afcdc366b20d199ab33c4ec60ed22a68
ToppCellP15-Endothelial-unknown_endothelial_cell-endothelial_unknown_1|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KDR TEX14 NRP1

2.64e-0418730360f41b1f1b656d211b80398aa2cf0ac0cdad9372
ToppCellP15-Endothelial-unknown_endothelial_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KDR TEX14 NRP1

2.64e-04187303d543ddc63f864b6d0982c4ff652af174af085c4a
ToppCelldroplet-Kidney-nan-3m-Endothelial-kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR P2RY1 NRP1

2.64e-04187303d72012e94857606f39975cf672f6b8c2e0fe093e
ToppCellMonocytes-M2-like_CD16+_macrophages|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis

KCNAB1 NRP1 TPCN1

2.64e-0418730359e31c51183ed4c9a3d0792c8005ea3a12b28dfa
ToppCellP03-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell_of_alveolus|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KDR TEX14 NRP1

2.64e-0418730355618ceec367c1c51ed5c447063d7fbd5c7e0808
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma|TCGA-Kidney / Sample_Type by Project: Shred V9

KCNAB1 KDR P2RY1

2.68e-04188303e711c7a46d7cfa030ca2982eacc1dae5af5788dd
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

2.68e-041883038a87daf2851d9404df7c36f279db599574b47c69
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

2.68e-041883030f426cca2ad7671fed9c6d2aa09f6a8627a518cd
ToppCell5'-Adult-Appendix-Endothelial-blood_vessel_EC-arterial_capillary|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KDR OR52I1 NRP1

2.68e-04188303a11b12f1857953bcdbfb5f25e127f2350c39567d
ToppCellNS-critical-d_16-33-Myeloid-Monocyte-derived_DC|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

KCNAB1 LPL NRP1

2.68e-0418830308eb1e4b719af53c52895557523d0a1b7421d849
ToppCellP15-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell_of_alveolus|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KDR TEX14 NRP1

2.68e-04188303c0a03e33027f52b5c25ffbc8f822128e5160ed20
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

2.68e-04188303aec7485f1a9412bd3a62b70c801cb7f8dcca232d
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

B3GALT2 KCNAB1 KDR

2.72e-04189303979b7fa947538aa7ca4a219263da2575869a2caa
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

KCNAB1 PLBD2 LPL

2.72e-041893030a490730cdc912d5233de59057550de0e4065747
ToppCelldroplet-Mammary_Gland-nan-3m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR HDC NRP1

2.72e-0418930325781edbd08c6e413740b796ecc8ba1934bd3aa5
ToppCellP07-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell_of_alveolus|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

KDR TEX14 NRP1

2.77e-041903035d25e40bc2cca314f4265e4001a546e6d99e2a79
ToppCellCOVID-19-Heart-EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

KCNAB1 KDR NRP1

2.77e-04190303a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCellfacs-Heart-RV-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

2.77e-0419030389d1d686cc683206534e2157554d7d0df5d53497
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

2.77e-04190303f98e2d45fab7d9e16629d7f13cc2ccfb939ef4dd
ToppCellfacs-Heart-RV-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

2.77e-0419030365ba6c4f4a2905c0bf4ff99518ae49e3dfd5e640
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KDR TEX14 NRP1

2.81e-04191303718330bb97fe8a1ffd0c82e9af23311a32eacfe1
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

2.81e-041913035020fe6c3452e7fab57847f5043d28ebbc5aa381
ToppCellSevere_COVID-19-Myeloid-TRAM3|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

KCNAB1 TEX14 LPL

2.81e-0419130305867b96199a46a415848409130697c810d18937
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KDR TEX14 NRP1

2.81e-04191303454034ad940377ee079afa8ce33f8e0bdeaf44f8
ToppCellBAL-Severe-Myeloid-TRAM|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

KCNAB1 TEX14 LPL

2.81e-041913034c4f50a502e3f6768a89df686fa2830b83b8b33f
ToppCellfacs-BAT-Fat-24m-Endothelial-endothelial_cell|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

2.81e-041913033550a5ed68e723182ddf85b019a6f2525a17bf52
ToppCellfacs-BAT-Fat-24m-Endothelial|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

2.81e-04191303245ce7d1a26f9aa47acd2827b22b997886919832
ToppCellBAL-Severe-Myeloid-TRAM|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KCNAB1 TEX14 LPL

2.81e-04191303de7c88bb46f794291025ef121a89fcd94dea4ffe
ToppCell(1)_Control_(PBS)|World / Stress and Cell class

KDR LPL NRP1

2.81e-04191303b346e13259cb2d506b923ad44b894c21a3eee4c3
ToppCellBAL-Severe-Myeloid-TRAM-TRAM3|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

KCNAB1 TEX14 LPL

2.81e-041913032b10a73c5d80e83d67a7121fb004a1aa86a537ef
ToppCellBAL-Severe-Myeloid-TRAM-TRAM3-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

KCNAB1 TEX14 LPL

2.81e-0419130302e1ae144da7274171e055356d10e8d175c5347f
ToppCellfacs-BAT-Fat-24m-Endothelial-nan|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

2.81e-0419130312a291918be26cb5d2b185f6a8996f4d23042cf4
ToppCelldroplet-Heart|droplet / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

2.85e-0419230367a7e07a11091120edbccf739836235c422ec9c6
ToppCellfacs-BAT-Fat-18m-Endothelial-nan|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

2.85e-04192303562e15876088af9189744c9b2de5c4863d7f15fd
ToppCellfacs-Heart-LA-18m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR HDC NRP1

2.85e-041923035238506f2bb8bd36a49d3012442f45063c0550e6
ToppCellfacs-BAT-Fat-18m-Endothelial|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

2.85e-041923033a99c521c599a289ee2309d97be5ceb99f8aa220
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KDR TEX14 NRP1

2.85e-041923039a1aeac3ecf31f865a23d8ee15a82aef31779089
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

2.85e-0419230324d28e28a5c54ca7770f7e5ad7f4d00039e0aaf9
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KDR TEX14 NRP1

2.85e-041923032360824910cd471c8286ca369ba144d90d984602
ToppCellfacs-BAT-Fat-18m-Endothelial-endothelial_cell|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KDR LPL NRP1

2.85e-04192303f9777e0fdd86c2a514f05a42502888329a94b396
ToppCellBAL-Severe-Myeloid-TRAM-TRAM3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

KCNAB1 TEX14 LPL

2.85e-0419230334505a13b8a47c9286c560122fa7861b9c331a08
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KDR TEX14 NRP1

2.85e-0419230353d438e35c14e7656585942b788459e6d843c555
ToppCellCOVID-19-Myeloid-TRAM1|COVID-19 / Condition, Lineage and Cell class

KCNAB1 TEX14 LPL

2.85e-0419230352b8578699325b0d35a2d3ba36772096130ccc0c
DiseaseX-14939 measurement

CYP4A11 CYP4A22

1.40e-056292EFO_0800747
Diseaseautosomal recessive polycystic kidney disease (biomarker_via_orthology)

CYP4A11 CYP4A22

5.10e-0511292DOID:0110861 (biomarker_via_orthology)
Diseasehypertension (biomarker_via_orthology)

KCNAB1 KDR CYP4A11 CYP4A22

6.97e-05227294DOID:10763 (biomarker_via_orthology)
Diseasediacylglycerol 44:7 measurement

IFT172 LPL

1.11e-0416292EFO_0020069
Diseasehypertension (is_implicated_in)

KDR CYP4A11 LPL

2.27e-04121293DOID:10763 (is_implicated_in)
Diseaseulcerative colitis (is_marker_for)

KDR TNFAIP3

7.11e-0440292DOID:8577 (is_marker_for)
Diseasenasopharynx carcinoma (is_marker_for)

KDR TNFAIP3

8.21e-0443292DOID:9261 (is_marker_for)
Diseasepsoriasis (is_marker_for)

KDR IL25

8.60e-0444292DOID:8893 (is_marker_for)
Diseasetriglycerides in very small VLDL measurement

R3HDM2 LPL

2.04e-0368292EFO_0022144
Diseasetriglyceride measurement, high density lipoprotein cholesterol measurement

R3HDM2 P2RY1 LPL

2.42e-03274293EFO_0004530, EFO_0004612
Diseasehepatocellular carcinoma (is_marker_for)

KDR TNFAIP3 NRP1

3.16e-03301293DOID:684 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
ITWNHLDQMPYTTMC

CYP4A11

361

Q02928
MDCEMHVYCQWQPSS

DMXL1

1231

Q9Y485
HFGAMVATMFCWVTA

ALG12

121

Q9BV10
ENMHMTSYPVSWSSV

CRISP1

101

P54107
NPSMVQWSHCKYYSM

R3HDM2

721

Q9Y2K5
HAVTMPCTWVMACAY

GNB5

141

O14775
THYQLASAMGPMSTW

RADIL

736

Q96JH8
WSAMQFVYCIPVGTH

CYFIP1

1131

Q7L576
FNPSKWMMVHFDCTG

HDC

301

P19113
FVFHMKPWSGISVYM

P2RY1

76

P47900
THVINQGMAMYWGTS

KCNAB1

226

Q14722
ASFPFGQCMEWYTMS

ATRN

966

O75882
FMVIHGWTVTGMYES

LPL

76

P06858
TISVWGCVTQMFFMH

OR4L1

91

Q8NH43
MILNFCSYMQWVPGS

IFT172

521

Q9UG01
CMTFWYHMSGSHVGT

NRP1

721

O14786
TLMGMNWVATYCPHI

B3GALT2

231

O43825
MSYTMWNLAGVPNVF

FBXL4

71

Q9UKA2
ITWNHLDQMPYTTMC

CYP4A22

361

Q5TCH4
VVSGEHYRFVSMWMA

TMEM259

286

Q4ZIN3
MVMGTHTYSHWPSCC

IL25

26

Q9H293
TAIWMDSTRHEPMYC

OR52I1

51

Q8NGK6
FHYFQRMSSWATCGM

TRMT13

361

Q9NUP7
YNQGMIWMGAFFSPC

TMC3

566

Q7Z5M5
SFFSGPYMVMTNLVW

TEX14

251

Q8IWB6
GNCLMHATSQYMWGV

TNFAIP3

101

P21580
MMPSYSRNPWSCVFF

TPCN1

286

Q9ULQ1
TTPEMYQTMLDCWHG

KDR

1131

P35968
FGPMCTHYTQMVWAT

PI15

166

O43692
YMHWMNTVVNYCGPF

PLBD2

131

Q8NHP8
VPPYSHQSSVWFEMM

GRIN1

141

Q05586