Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	endopeptidase activity	PAPPA2 PCSK5 CTSF ADAMTS3 ADAMTS2 CASP9 ADAMTS8 TLL1 PCSK6 PCSK7 ADAMTS14 ADAMTSL2	1.04e-06	430	96	12	GO:0004175
GeneOntologyMolecularFunction	metalloendopeptidase activity	PAPPA2 ADAMTS3 ADAMTS2 ADAMTS8 TLL1 ADAMTS14 ADAMTSL2	1.82e-06	120	96	7	GO:0004222
GeneOntologyMolecularFunction	peptidase activity	PAPPA2 PCSK5 DPP6 CTSF ADAMTS3 ADAMTS2 CASP9 ADAMTS8 TLL1 PCSK6 OTUD7A PCSK7 ADAMTS14 ADAMTSL2	2.86e-06	654	96	14	GO:0008233
GeneOntologyMolecularFunction	metallopeptidase activity	PAPPA2 ADAMTS3 ADAMTS2 ADAMTS8 TLL1 ADAMTS14 ADAMTSL2	5.11e-05	200	96	7	GO:0008237
GeneOntologyMolecularFunction	zinc ion binding	PAPPA2 ADAMTS3 ADAMTS2 ZIM2 ADAMTS8 PTER PHC1 ZBTB32 LACTB2 ZPR1 TLL1 OTUD7A HERC2	3.33e-04	891	96	13	GO:0008270
GeneOntologyBiologicalProcess	positive regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	6.28e-05	3	95	2	GO:0002879
GeneOntologyBiologicalProcess	Wnt signaling pathway, planar cell polarity pathway	FZD1 FZD6 CCDC88C CELSR1	1.20e-04	55	95	4	GO:0060071
GeneOntologyBiologicalProcess	establishment of body hair planar orientation	FZD6 CELSR1	1.25e-04	4	95	2	GO:0048105
GeneOntologyBiologicalProcess	establishment of body hair or bristle planar orientation	FZD6 CELSR1	1.25e-04	4	95	2	GO:0048104
GeneOntologyBiologicalProcess	regulation of acute inflammatory response to non-antigenic stimulus	FFAR3 GPR42	1.25e-04	4	95	2	GO:0002877
GeneOntologyCellularComponent	extracellular matrix	COL4A1 FRAS1 CTSF ADAMTS3 ADAMTS2 ADAMTS8 PCSK6 ADAMTS14 ADAMTSL2 OTOG PCOLCE	2.10e-04	656	96	11	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	COL4A1 FRAS1 CTSF ADAMTS3 ADAMTS2 ADAMTS8 PCSK6 ADAMTS14 ADAMTSL2 OTOG PCOLCE	2.15e-04	658	96	11	GO:0030312
Domain	PLAC	PCSK5 ADAMTS3 ADAMTS2 PCSK6 ADAMTS14 ADAMTSL2	4.59e-10	19	98	6	PS50900
Domain	PLAC	PCSK5 ADAMTS3 ADAMTS2 PCSK6 ADAMTS14 ADAMTSL2	4.59e-10	19	98	6	IPR010909
Domain	ADAM_spacer1	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14 ADAMTSL2	1.12e-07	23	98	5	IPR010294
Domain	ADAM_spacer1	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14 ADAMTSL2	1.12e-07	23	98	5	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14 ADAMTSL2	1.41e-07	24	98	5	IPR013273
Domain	MetalloPept_cat_dom	PAPPA2 ADAMTS3 ADAMTS2 ADAMTS8 TLL1 ADAMTS14	4.22e-06	81	98	6	IPR024079
Domain	-	PAPPA2 ADAMTS3 ADAMTS2 ADAMTS8 TLL1 ADAMTS14	4.22e-06	81	98	6	3.40.390.10
Domain	PrprotnconvertsP	PCSK5 PCSK6 PCSK7	4.83e-06	7	98	3	IPR002884
Domain	P_proprotein	PCSK5 PCSK6 PCSK7	4.83e-06	7	98	3	PF01483
Domain	S8_pro-domain	PCSK5 PCSK6 PCSK7	4.83e-06	7	98	3	IPR032815
Domain	-	PCSK5 PCSK6 PCSK7	4.83e-06	7	98	3	3.30.70.850
Domain	S8_pro-domain	PCSK5 PCSK6 PCSK7	4.83e-06	7	98	3	PF16470
Domain	EGF-like_dom	PCSK5 FRAS1 ITGBL1 CELSR1 SCUBE2 TLL1 PCSK6 TENM1 OTOG	6.46e-06	249	98	9	IPR000742
Domain	Peptidase_S8_His-AS	PCSK5 PCSK6 PCSK7	1.15e-05	9	98	3	IPR022398
Domain	Peptidase_S8_Ser-AS	PCSK5 PCSK6 PCSK7	1.15e-05	9	98	3	IPR023828
Domain	ZINC_PROTEASE	PAPPA2 ADAMTS3 ADAMTS2 ADAMTS8 TLL1 ADAMTS14	1.28e-05	98	98	6	PS00142
Domain	Peptidase_S8_subtilisin-rel	PCSK5 PCSK6 PCSK7	1.64e-05	10	98	3	IPR015500
Domain	SUBTILASE_ASP	PCSK5 PCSK6 PCSK7	1.64e-05	10	98	3	PS00136
Domain	SUBTILASE_HIS	PCSK5 PCSK6 PCSK7	1.64e-05	10	98	3	PS00137
Domain	SUBTILASE_SER	PCSK5 PCSK6 PCSK7	1.64e-05	10	98	3	PS00138
Domain	TSP_1	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14 ADAMTSL2	1.98e-05	63	98	5	PF00090
Domain	-	PCSK5 PCSK6 PCSK7	2.24e-05	11	98	3	3.40.50.200
Domain	Peptidase_S8/S53_dom	PCSK5 PCSK6 PCSK7	2.24e-05	11	98	3	IPR000209
Domain	Peptidase_S8	PCSK5 PCSK6 PCSK7	2.24e-05	11	98	3	PF00082
Domain	TSP1	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14 ADAMTSL2	2.31e-05	65	98	5	SM00209
Domain	TSP1_rpt	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14 ADAMTSL2	2.31e-05	65	98	5	IPR000884
Domain	TSP1	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14 ADAMTSL2	2.31e-05	65	98	5	PS50092
Domain	EGF	PCSK5 FRAS1 ITGBL1 CELSR1 SCUBE2 TLL1 PCSK6 TENM1	3.31e-05	235	98	8	SM00181
Domain	PLAC	PCSK5 PCSK6 ADAMTSL2	4.89e-05	14	98	3	PF08686
Domain	Peptidase_M12B_N	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14	5.09e-05	39	98	4	IPR002870
Domain	Pep_M12B_propep	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14	5.09e-05	39	98	4	PF01562
Domain	DISINTEGRIN_1	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14	5.63e-05	40	98	4	PS00427
Domain	Reprolysin	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14	5.63e-05	40	98	4	PF01421
Domain	ADAM_MEPRO	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14	5.63e-05	40	98	4	PS50215
Domain	DISINTEGRIN_2	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14	5.63e-05	40	98	4	PS50214
Domain	Peptidase_M12B	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14	5.63e-05	40	98	4	IPR001590
Domain	Disintegrin_dom	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14	6.22e-05	41	98	4	IPR001762
Domain	Propept_inh	PCSK5 PCSK6 PCSK7	9.03e-05	17	98	3	IPR009020
Domain	Furin_repeat	PCSK5 FRAS1 PCSK6	1.08e-04	18	98	3	IPR006212
Domain	FU	PCSK5 FRAS1 PCSK6	1.08e-04	18	98	3	SM00261
Domain	CUB	CSMD2 SCUBE2 TLL1 PCOLCE	1.26e-04	49	98	4	PF00431
Domain	CUB	CSMD2 SCUBE2 TLL1 PCOLCE	1.36e-04	50	98	4	SM00042
Domain	-	CSMD2 SCUBE2 TLL1 PCOLCE	1.59e-04	52	98	4	2.60.120.290
Domain	GPR40-rel_orph	FFAR3 GPR42	1.62e-04	4	98	2	IPR013312
Domain	CUB	CSMD2 SCUBE2 TLL1 PCOLCE	1.71e-04	53	98	4	PS01180
Domain	CUB_dom	CSMD2 SCUBE2 TLL1 PCOLCE	2.27e-04	57	98	4	IPR000859
Domain	GF_recep_IV	PCSK5 PCSK6	4.03e-04	6	98	2	PF14843
Domain	GF_recep_IV	PCSK5 PCSK6	4.03e-04	6	98	2	IPR032778
Domain	Peptidase_S8_Asp-AS	PCSK5 PCSK6	4.03e-04	6	98	2	IPR023827
Domain	-	PCSK5 PCSK6 PCSK7 HERC2	5.88e-04	73	98	4	2.60.120.260
Domain	Growth_fac_rcpt_	PCSK5 FRAS1 CELSR1 SCUBE2 PCSK6	1.39e-03	156	98	5	IPR009030
Domain	Frizzled	FZD1 FZD6	1.45e-03	11	98	2	IPR000539
Domain	Frizzled	FZD1 FZD6	1.45e-03	11	98	2	PF01534
Domain	Frizzled	FZD1 FZD6	1.45e-03	11	98	2	SM01330
Domain	Galactose-bd-like	PCSK5 PCSK6 PCSK7 HERC2	1.51e-03	94	98	4	IPR008979
Domain	Myotubularin-like_Pase_dom	MTMR1 MTMR3	2.38e-03	14	98	2	IPR010569
Domain	PPASE_MYOTUBULARIN	MTMR1 MTMR3	2.38e-03	14	98	2	PS51339
Domain	Myotubularin_fam	MTMR1 MTMR3	2.38e-03	14	98	2	IPR030564
Domain	Myotub-related	MTMR1 MTMR3	2.38e-03	14	98	2	PF06602
Domain	Frizzled/SFRP	FZD1 FZD6	3.12e-03	16	98	2	IPR015526
Domain	GPCR_2_secretin-like	FZD1 FZD6 CELSR1	3.86e-03	60	98	3	IPR000832
Domain	GPCR_2-like	FZD1 FZD6 CELSR1	3.86e-03	60	98	3	IPR017981
Domain	G_PROTEIN_RECEP_F2_4	FZD1 FZD6 CELSR1	4.04e-03	61	98	3	PS50261
Domain	VWC_out	FRAS1 OTOG	4.40e-03	19	98	2	SM00215
Domain	RCC1	HERC3 HERC2	4.87e-03	20	98	2	PF00415
Domain	FRI	FZD1 FZD6	4.87e-03	20	98	2	SM00063
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	COL4A1 ADAMTS3 ADAMTS2 TLL1 ADAMTS14 PCOLCE	1.03e-06	61	78	6	MM14637
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	COL4A1 ADAMTS3 ADAMTS2 TLL1 ADAMTS14 PCOLCE	1.80e-06	67	78	6	M26999
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14 ADAMTSL2	2.26e-06	39	78	5	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14 ADAMTSL2	2.26e-06	39	78	5	MM15165
Pathway	REACTOME_COLLAGEN_FORMATION	COL4A1 ADAMTS3 ADAMTS2 TLL1 ADAMTS14 PCOLCE	3.79e-06	76	78	6	MM14573
Pathway	REACTOME_COLLAGEN_FORMATION	COL4A1 ADAMTS3 ADAMTS2 TLL1 ADAMTS14 PCOLCE	1.02e-05	90	78	6	M631
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14 ADAMTSL2	3.62e-05	68	78	5	M27303
Pathway	REACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS	COL4A1 TLL1 PCOLCE	1.25e-04	18	78	3	M27164
Pathway	REACTOME_CROSSLINKING_OF_COLLAGEN_FIBRILS	COL4A1 TLL1 PCOLCE	1.25e-04	18	78	3	MM14882
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14 ADAMTSL2	3.40e-04	109	78	5	MM15164
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14 ADAMTSL2	3.70e-04	111	78	5	M27416
Pubmed	The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology.	ADAMTS3 ADAMTS2 ADAMTS14	2.17e-08	3	98	3	25863161
Pubmed	Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3.	ADAMTS3 ADAMTS2 ADAMTS14	2.17e-08	3	98	3	11741898
Pubmed	Maturation of HIV envelope glycoprotein precursors by cellular endoproteases.	PCSK5 PCSK6 PCSK7	2.17e-08	3	98	3	11063880
Pubmed	Retroviral envelope glycoprotein processing: structural investigation of the cleavage site.	PCSK5 PCSK6 PCSK7	8.66e-08	4	98	3	9521771
Pubmed	Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina.	ADAMTS3 ADAMTS2 ADAMTS14	8.66e-08	4	98	3	22205175
Pubmed	Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.	PCSK5 PCSK6 PCSK7	2.16e-07	5	98	3	18664504
Pubmed	Proprotein convertase expression and localization in epidermis: evidence for multiple roles and substrates.	PCSK5 PCSK6 PCSK7	2.16e-07	5	98	3	11380615
Pubmed	Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines.	PCSK5 PCSK6 PCSK7	4.31e-07	6	98	3	8940009
Pubmed	Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis.	ADAMTS3 ADAMTS2 ADAMTS14	4.31e-07	6	98	3	16556917
Pubmed	Proteolytic processing in the secretory pathway.	PCSK5 PCSK6 PCSK7	7.53e-07	7	98	3	10409610
Pubmed	The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.	PCSK5 PCSK6 PCSK7	7.53e-07	7	98	3	7819324
Pubmed	Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.	PCSK5 PCSK6 PCSK7	1.20e-06	8	98	3	9885250
Pubmed	Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals.	PCSK5 PCSK6 PCSK7	1.20e-06	8	98	3	10037747
Pubmed	The activation and physiological functions of the proprotein convertases.	PCSK5 PCSK6 PCSK7	1.80e-06	9	98	3	18343183
Pubmed	The prohormone theory and the proprotein convertases: it is all about serendipity.	PCSK5 PCSK6 PCSK7	1.80e-06	9	98	3	21805236
Pubmed	The proprotein convertases, 20 years later.	PCSK5 PCSK6 PCSK7	1.80e-06	9	98	3	21805237
Pubmed	The biology and therapeutic targeting of the proprotein convertases.	PCSK5 PCSK6 PCSK7	1.80e-06	9	98	3	22679642
Pubmed	The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions.	PCSK5 PCSK6 PCSK7	1.80e-06	9	98	3	23775089
Pubmed	SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis.	PCSK5 PCSK6 PCSK7	1.80e-06	9	98	3	8698813
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14 ADAMTSL2	2.37e-06	75	98	5	20637190
Pubmed	Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.	PCSK5 PCSK6 PCSK7	2.57e-06	10	98	3	16163737
Pubmed	Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia.	FFAR3 GPR42	7.86e-06	2	98	2	25637492
Pubmed	Selective tracking of FFAR3-expressing neurons supports receptor coupling to N-type calcium channels in mouse sympathetic neurons.	FFAR3 GPR42	7.86e-06	2	98	2	30478340
Pubmed	3-(4-Hydroxy-3-methoxyphenyl) propionic acid contributes to improved hepatic lipid metabolism via GPR41.	FFAR3 GPR42	7.86e-06	2	98	2	38040866
Pubmed	Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APPswe Alzheimer's Disease Mouse Model.	FFAR3 GPR42	7.86e-06	2	98	2	35408893
Pubmed	FFAR3 modulates insulin secretion and global gene expression in mouse islets.	FFAR3 GPR42	7.86e-06	2	98	2	26091414
Pubmed	GPR41 modulates insulin secretion and gene expression in pancreatic β-cells and modifies metabolic homeostasis in fed and fasting states.	FFAR3 GPR42	7.86e-06	2	98	2	27550964
Pubmed	Intestinal FFA3 mediates obesogenic effects in mice on a Western diet.	FFAR3 GPR42	7.86e-06	2	98	2	35858247
Pubmed	Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms.	FFAR3 GPR42	7.86e-06	2	98	2	22506074
Pubmed	Free fatty acid receptor 3 differentially contributes to β-cell compensation under high-fat diet and streptozotocin stress.	FFAR3 GPR42	7.86e-06	2	98	2	32073900
Pubmed	Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases.	PCSK5 PCSK6	7.86e-06	2	98	2	18061232
Pubmed	The effects of propionate and valerate on insulin responsiveness for glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes via G protein-coupled receptor 41.	FFAR3 GPR42	7.86e-06	2	98	2	24748202
Pubmed	The Cognitive Improvement and Alleviation of Brain Hypermetabolism Caused by FFAR3 Ablation in Tg2576 Mice Is Persistent under Diet-Induced Obesity.	FFAR3 GPR42	7.86e-06	2	98	2	36362376
Pubmed	Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.	FFAR3 GPR42	7.86e-06	2	98	2	20399779
Pubmed	Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease.	PCSK5 PCSK6	7.86e-06	2	98	2	8335106
Pubmed	Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42.	FFAR3 GPR42	7.86e-06	2	98	2	19630535
Pubmed	Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function.	ADAMTS2 ADAMTS14	7.86e-06	2	98	2	37929635
Pubmed	Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4.	PCSK5 PCSK6	7.86e-06	2	98	2	8468318
Pubmed	Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content.	FFAR3 GPR42	7.86e-06	2	98	2	23110765
Pubmed	The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation.	FFAR3 GPR42	7.86e-06	2	98	2	26522986
Pubmed	Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.	FFAR3 GPR42	7.86e-06	2	98	2	14722361
Pubmed	Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41.	FFAR3 GPR42	7.86e-06	2	98	2	27664183
Pubmed	Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.	FFAR3 GPR42	7.86e-06	2	98	2	26260360
Pubmed	ADAMTS2 and ADAMTS14 can substitute for ADAMTS3 in adults for pro-VEGFC activation and lymphatic homeostasis.	ADAMTS2 ADAMTS14	7.86e-06	2	98	2	35316211
Pubmed	G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation.	FFAR3 GPR42	7.86e-06	2	98	2	37019194
Pubmed	Spontaneous atopic dermatitis due to immune dysregulation in mice lacking Adamts2 and 14.	ADAMTS2 ADAMTS14	7.86e-06	2	98	2	29649548
Pubmed	ADAMTS2 promotes radial migration by activating TGF-β signaling in the developing neocortex.	ADAMTS3 ADAMTS2 ADAMTS14	9.63e-06	15	98	3	38871984
Pubmed	Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.	PCSK5 PCSK6 PCSK7	1.18e-05	16	98	3	20876279
Pubmed	Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation.	FFAR3 GPR42	2.35e-05	3	98	2	22673524
Pubmed	The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.	FFAR3 GPR42	2.35e-05	3	98	2	12496283
Pubmed	Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.	FFAR3 GPR42	2.35e-05	3	98	2	23665276
Pubmed	Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer.	FFAR3 GPR42	2.35e-05	3	98	2	34210970
Pubmed	Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain.	ADAMTS2 ADAMTS14	2.35e-05	3	98	2	31152061
Pubmed	Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3.	FFAR3 GPR42	2.35e-05	3	98	2	31719611
Pubmed	Somatic mutations in planar cell polarity genes in neural tissue from human fetuses with neural tube defects.	FZD6 CELSR1	2.35e-05	3	98	2	32356230
Pubmed	Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43.	FFAR3 GPR42	2.35e-05	3	98	2	16123168
Pubmed	Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases.	PCSK5 PCSK6	2.35e-05	3	98	2	8670066
Pubmed	GPR41 gene expression is mediated by internal ribosome entry site (IRES)-dependent translation of bicistronic mRNA encoding GPR40 and GPR41 proteins.	FFAR3 GPR42	2.35e-05	3	98	2	22493486
Pubmed	Induction of human ADAMTS-2 gene expression by IL-1α is mediated by a multiple crosstalk of MEK/JNK and PI3K pathways in osteoblast like cells.	ADAMTS3 ADAMTS2	2.35e-05	3	98	2	26232334
Pubmed	Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains.	TLL1 PCOLCE	2.35e-05	3	98	2	16507574
Pubmed	Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3.	FFAR3 GPR42	2.35e-05	3	98	2	23066016
Pubmed	Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes.	FFAR3 GPR42	2.35e-05	3	98	2	25581519
Pubmed	Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.	FFAR3 GPR42	2.35e-05	3	98	2	22190648
Pubmed	Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains.	PCSK5 PCSK7	2.35e-05	3	98	2	11723118
Pubmed	IL-6 upregulates a disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS-2) in human osteosarcoma cells mediated by JNK pathway.	ADAMTS3 ADAMTS2	2.35e-05	3	98	2	24752352
Pubmed	Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.	FFAR3 GPR42	2.35e-05	3	98	2	31272808
Pubmed	GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.	FFAR3 GPR42	2.35e-05	3	98	2	23885020
Pubmed	Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism.	FFAR3 GPR42	2.35e-05	3	98	2	29768180
Pubmed	Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.	FFAR3 GPR42	2.35e-05	3	98	2	18931303
Pubmed	GPR41 and GPR43 regulate CD8+ T cell priming during herpes simplex virus type 1 infection.	FFAR3 GPR42	2.35e-05	3	98	2	38524121
Pubmed	Subtilisin-like proprotein convertases, PACE4 and PC8, as well as furin, are endogenous proalbumin convertases in HepG2 cells.	PCSK6 PCSK7	2.35e-05	3	98	2	10050053
Pubmed	Abnormalities in microbiota/butyrate/FFAR3 signaling in aging gut impair brain function.	FFAR3 GPR42	2.35e-05	3	98	2	38329121
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DSC2 DBNL PTER MADD CEP350 CCDC88C LIMK1 STARD9 OTUD7A KIF14 OTOG	3.18e-05	861	98	11	36931259
Pubmed	Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.	COL4A1 FRAS1 ADAMTS3 ADAMTS8	3.31e-05	64	98	4	22261194
Pubmed	Region-specific reversal of epidermal planar polarity in the rosette fancy mouse.	FZD6 CELSR1	4.70e-05	4	98	2	37622728
Pubmed	CDMP1/GDF5 has specific processing requirements that restrict its action to joint surfaces.	PCSK5 PCSK6	4.70e-05	4	98	2	16829522
Pubmed	Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases.	PCSK5 PCSK6	4.70e-05	4	98	2	8615794
Pubmed	Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation.	FFAR3 GPR42	4.70e-05	4	98	2	23401498
Pubmed	Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.	PCSK5 PCSK7	4.70e-05	4	98	2	23686857
Pubmed	Neurotrophin secretion: current facts and future prospects.	PCSK5 PCSK6	4.70e-05	4	98	2	12787574
Pubmed	A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.	FFAR3 GPR42	4.70e-05	4	98	2	9344866
Pubmed	Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2.	PCSK5 PCSK7	4.70e-05	4	98	2	17242158
Pubmed	Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder.	PCSK6 PCSK7	4.70e-05	4	98	2	26283733
Pubmed	Celsr1 adhesive interactions mediate the asymmetric organization of planar polarity complexes.	FZD6 CELSR1	4.70e-05	4	98	2	33529151
Pubmed	Functional redundancy in the myotubularin family.	MTMR1 MTMR3	4.70e-05	4	98	2	11846405
Pubmed	Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41).	FFAR3 GPR42	4.70e-05	4	98	2	21518883
Pubmed	The proprotein convertases furin and PACE4 play a significant role in tumor progression.	PCSK5 PCSK6	4.70e-05	4	98	2	10900462
Pubmed	A family of fatty acid binding receptors.	FFAR3 GPR42	4.70e-05	4	98	2	15684720
Pubmed	ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats.	ADAMTS3 ADAMTS2	4.70e-05	4	98	2	10094461
Pubmed	Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice.	FFAR3 GPR42	4.70e-05	4	98	2	29021375
Pubmed	Microbial metabolites, short-chain fatty acids, restrain tissue bacterial load, chronic inflammation, and associated cancer in the colon of mice.	FFAR3 GPR42	4.70e-05	4	98	2	29644622
Pubmed	[ADAMTS family--new extracellular matrix degrading enzyme].	ADAMTS3 ADAMTS2	7.82e-05	5	98	2	11831030
Pubmed	Non-association between polymorphisms of the frizzled receptor genes and bone mineral density in postmenopausal Korean women.	FZD1 FZD6	7.82e-05	5	98	2	19543507
Pubmed	New mouse models for high resolution and live imaging of planar cell polarity proteins in vivo.	FZD6 CELSR1	7.82e-05	5	98	2	34463728
Pubmed	Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability.	HERC3 HERC2	7.82e-05	5	98	2	22124266
Pubmed	Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: a genetic association study.	ADAMTS2 ADAMTS14	7.82e-05	5	98	2	23491141
Pubmed	Fatty acid binding receptors and their physiological role in type 2 diabetes.	FFAR3 GPR42	7.82e-05	5	98	2	19009545
Pubmed	A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast.	MTMR1 MTMR3	7.82e-05	5	98	2	8640223
Pubmed	Processing of prothyrotropin-releasing hormone by the family of prohormone convertases.	PCSK5 PCSK6	7.82e-05	5	98	2	9242664
Pubmed	Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.	FFAR3 GPR42	7.82e-05	5	98	2	24327954
Interaction	PMCH interactions	PCSK5 PCSK6 PCSK7 HERC2	7.24e-06	26	98	4	int:PMCH
Cytoband	19q13.1	FFAR3 GPR42 ZBTB32	2.28e-04	55	98	3	19q13.1
Cytoband	8q13.3	SLCO5A1 LACTB2	7.53e-04	19	98	2	8q13.3
Cytoband	4q21	AFF1 HERC3	8.36e-04	20	98	2	4q21
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	GARIN5B ZNF586 FFAR3 GPR42 ZIM2 ZNF284 ZBTB32 SLC17A7 ZNF749	1.04e-03	1192	98	9	chr19q13
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS3 ADAMTS2 ADAMTS8 ADAMTS14	7.64e-07	19	70	4	50
GeneFamily	Proprotein convertase subtilisin/kexin family	PCSK5 PCSK6 PCSK7	4.59e-06	9	70	3	973
GeneFamily	G protein-coupled receptors, Class F frizzled	FZD1 FZD6	7.95e-04	11	70	2	286
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	MTMR1 MTMR3	1.50e-03	15	70	2	903
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF586 ZNF266 ZIM2 RREB1 ZNF284 ZSCAN29 ZBTB32 ZNF749 ZNF554	1.74e-03	718	70	9	28
Coexpression	NABA_ECM_REGULATORS	PAPPA2 PCSK5 CTSF ADAMTS3 ADAMTS2 ADAMTS8 TLL1 PCSK6 ADAMTS14 ADAMTSL2	2.20e-08	238	98	10	M3468
Coexpression	NABA_ECM_REGULATORS	PAPPA2 PCSK5 CTSF ADAMTS3 ADAMTS2 ADAMTS8 TLL1 PCSK6 ADAMTS14 ADAMTSL2	2.57e-08	242	98	10	MM17062
Coexpression	NABA_MATRISOME	COL4A1 PAPPA2 PCSK5 FRAS1 CTSF ADAMTS3 ADAMTS2 ADAMTS8 SCUBE2 TLL1 PCSK6 ADAMTS14 ADAMTSL2 OTOG PCOLCE	4.96e-06	1008	98	15	MM17056
Coexpression	NABA_MATRISOME	COL4A1 PAPPA2 PCSK5 FRAS1 CTSF ADAMTS3 ADAMTS2 ADAMTS8 SCUBE2 TLL1 PCSK6 ADAMTS14 ADAMTSL2 OTOG PCOLCE	6.13e-06	1026	98	15	M5889
Coexpression	LAKE_ADULT_KIDNEY_C5_PROXIMAL_TUBULE_EPITHELIAL_CELLS_STRESS_INFLAM	COL4A1 PAPPA2 PCSK5 FRAS1 ADAMTS8 CSMD2 ZNF804B OTUD7A PPP6R2	2.70e-05	417	98	9	M39224
Coexpression	GAO_LARGE_INTESTINE_24W_C1_DCLK1POS_PROGENITOR	ADAMTS2 PHC1 FZD1 SCUBE2 PCOLCE	3.57e-05	99	98	5	M39152
CoexpressionAtlas	FacebaseRNAseq_e8.5_Non-Floor Plate Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#5	DCAF6 ADAMTS3 MTMR1 MADD ZSCAN29 CEP350 SLCO5A1 CCDC88C STARD9 TLL1 PCSK6 NUP210 HERC3 CFAP418 PPP6R2 ADAMTSL2	1.71e-07	732	96	16	Facebase_RNAseq_e8.5_Non-Floor Plate Neural Epithelium_2500_K5
CoexpressionAtlas	FacebaseRNAseq_e9.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#2	DCAF6 ADAMTS3 MTMR1 MADD ZSCAN29 CEP350 SLCO5A1 CCDC88C TLL1 PCSK6 HERC3 CFAP418 PPP6R2 ADAMTSL2	6.52e-06	747	96	14	Facebase_RNAseq_e9.5_Maxillary Arch_2500_K2
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_top-relative-expression-ranked_2500_k-means-cluster#4	DCAF6 ADAMTS3 MTMR1 MADD ZSCAN29 CEP350 SLCO5A1 PCSK6 MTMR3 HERC3 CFAP418 PPP6R2 ADAMTSL2	2.16e-05	721	96	13	Facebase_RNAseq_ratio_e9.5_MandibularArch_vs_MaxillaryArch_2500_K4
CoexpressionAtlas	FacebaseRNAseq_e9.5_Facial Mesenchyne_top-relative-expression-ranked_2500_k-means-cluster#5	DCAF6 ADAMTS3 MTMR1 MADD ZSCAN29 CEP350 SLCO5A1 TLL1 PCSK6 NUP210 HERC3 CFAP418 PPP6R2	2.19e-05	722	96	13	Facebase_RNAseq_e9.5_Facial Mesenchyne_2500_K5
CoexpressionAtlas	FacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_2500_k-means-cluster#3	DCAF6 ADAMTS3 MTMR1 MADD ZSCAN29 CEP350 SLCO5A1 PCSK6 MTMR3 HERC3 CFAP418 ADAMTSL2	1.11e-04	730	96	12	Facebase_RNAseq_e8.5_Paraxial Mesoderm_2500_K3
CoexpressionAtlas	FacebaseRNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_top-relative-expression-ranked_2500_k-means-cluster#5	DCAF6 ADAMTS3 MTMR1 MADD ZSCAN29 CEP350 SLCO5A1 PCSK6 HERC3 CFAP418 PPP6R2 ADAMTSL2	1.31e-04	743	96	12	Facebase_RNAseq_ratio_e9.5_MaxillaryArch_vs_Mandibular_2500_K5
ToppCell	PCW_07-8.5-Epithelial\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HNF1B NIBAN1 FRAS1 FZD6 CELSR1 TLL1 ZNF804B NUP210	1.17e-08	194	98	8	f63ceedb88a9abc8644ee94adfd541e7817c1e3a
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PAPPA2 PCSK5 FRAS1 ADAMTS2 LAMP5 PTER KIF14	1.96e-08	134	98	7	cb676d5bbc468bd3ce1b6712d41c986ee9221ac5
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A1 ADAMTS3 ADAMTS2 CSMD2 ITGBL1 TENM1 ADAMTSL2	1.79e-07	185	98	7	9faa35ceb89ccd2979072286f063687c9f846ce3
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_intermediate_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HNF1B NIBAN1 FRAS1 FZD6 CELSR1 ZNF804B NUP210	2.14e-07	190	98	7	c95032bb3ee2b3d40fdf48016acb46d6f78a48a6
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 CTSF ADAMTS3 ADAMTS2 ITGBL1 SCUBE2 PCOLCE	2.83e-07	198	98	7	524305c5d7b1d53e86ec0af775efefa3e0955e47
ToppCell	metastatic_Brain-T/NK_cells-Cytotoxic_CD8+_T\|T/NK_cells / Location, Cell class and cell subclass	MYCL PCSK5 HNF1B ADAMTS2 CELSR1 PCSK7	1.53e-06	161	98	6	e6e294b4ba911c1327664f1a0f93207096c6de03
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	DPP6 FRAS1 ADAMTS2 ADAMTS8 ITGBL1 ADAMTSL2	3.65e-06	187	98	6	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	COL4A1 ADAMTS8 ADARB2 CCDC88C TENM1 ADAMTSL2	3.88e-06	189	98	6	b6d5dec55bf352f6ae19d8f488ae70aa10fb9a8f
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HNF1B NIBAN1 FRAS1 CELSR1 TLL1 ZNF804B	3.88e-06	189	98	6	7659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCell	ASK454-Mesenchymal\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	PCSK5 FRAS1 ADAMTS8 ITGBL1 TENM1 PCOLCE	4.12e-06	191	98	6	e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCell	ASK454-Mesenchymal-Fibroblast\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	PCSK5 FRAS1 ADAMTS8 ITGBL1 TENM1 PCOLCE	4.12e-06	191	98	6	1726add3f392a061536b7aff72ba84303f4a0b1f
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	MYCL HNF1B NIBAN1 FRAS1 CELSR1 ZNF804B	4.24e-06	192	98	6	b99f8236ef4ccdc75c02abea381cae6453205f6f
ToppCell	droplet-Trachea-nan-3m-Mesenchymal-mesenchymal_progenitor_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A1 PAPPA2 ADAMTS2 FZD1 ITGBL1 PCOLCE	4.50e-06	194	98	6	3d25d6ebec8d1b6001f602257cd15b3ba04cf0c1
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HNF1B NIBAN1 FRAS1 CELSR1 TLL1 ZNF804B	4.50e-06	194	98	6	f95c8dc242c9aebcadfe61b1ed033349cb7e5a88
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL4A1 PAPPA2 ADAMTS2 FZD1 ITGBL1 PCOLCE	4.50e-06	194	98	6	ff19fb5bc7feae3e774ef4ab720beb9dec219f45
ToppCell	Tracheal-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS2 LAMP5 FZD1 ITGBL1 ADAMTSL2 PCOLCE	5.06e-06	198	98	6	7d2fe57e0f9311ac1e6854402ebc154306eb1ba5
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A1 PCSK5 CTSF ADAMTS2 SCUBE2 PCOLCE	5.06e-06	198	98	6	b086af292a508a156266c2d899ba1caf820bf61c
ToppCell	Cerebellum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Acta2Rgs5.Acta2_(Mural.Acta2Rgs5.Acta2)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PAPPA2 ADAMTS8 P2RX5 ADAMTS14 MUTYH	5.15e-06	113	98	5	7c5317bda7f13649af4837ca717dfdad74152f8f
ToppCell	Cerebellum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Acta2Rgs5.Acta2_(Mural.Acta2Rgs5.Acta2)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PAPPA2 ADAMTS8 P2RX5 ADAMTS14 MUTYH	5.15e-06	113	98	5	3c745f4d975475860e793f304a846b032515b334
ToppCell	Cerebellum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1\|Cerebellum / BrainAtlas - Mouse McCarroll V32	PAPPA2 ADAMTS8 P2RX5 ADAMTS14 MUTYH	5.15e-06	113	98	5	d67022ae14fae91f9f21ebe8c6ab6d8d6d725bc4
ToppCell	droplet-Limb_Muscle-nan-3m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 CTSF ADAMTS3 ITGBL1 SCUBE2 PCOLCE	5.21e-06	199	98	6	edd5300da1a3b758210ff8f949e9d1988b8bc7e2
ToppCell	(5)_Fibroblast-B_(Myofibroblast)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	COL4A1 CTSF ADAMTS2 LAMP5 ITGBL1 PCOLCE	5.36e-06	200	98	6	9bbaa666d0f3b4782c1b4b95e0fa5fc1467842d8
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	COL4A1 ADAMTS2 ITGBL1 STARD9 TENM1 PCOLCE	5.36e-06	200	98	6	0c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Hpgd\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PAPPA2 PCSK5 LAMP5 CCDC88C KIF14	8.77e-06	126	98	5	9b04ca8a46cc30119baf6ef27711a0b2a6b4a0c9
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Slco2a1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PAPPA2 PCSK5 FRAS1 ADAMTS2 PTER	1.14e-05	133	98	5	9d7a08170d38ae9b2ff10a0fa505aeb3aae2824d
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-10\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ADAMTS3 PCDHGA9 LAMP5 FZD1 ITGBL1	2.31e-05	154	98	5	511923b27469ea20f8bd82a9ec27119a6e884644
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Tall_Cell-1\|TCGA-Thryoid / Sample_Type by Project: Shred V9	DSC2 ADAMTS2 CD1B ITGBL1 ADAMTS14	2.46e-05	156	98	5	45a05c7a45a3ec8551818ab67f18b3b9553934c1
ToppCell	368C-Fibroblasts-Fibroblast-F\|368C / Donor, Lineage, Cell class and subclass (all cells)	FZD1 LMX1A PCSK6 OTUD7A SLC17A7	2.54e-05	157	98	5	74038192f016f95f80e0189035ee8ccc22ceb1b8
ToppCell	368C-Fibroblasts-Fibroblast-F-\|368C / Donor, Lineage, Cell class and subclass (all cells)	FZD1 LMX1A PCSK6 OTUD7A SLC17A7	2.54e-05	157	98	5	982e6ea78c7dabdb7c07c4a5fb2425d5e45b5b94
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NIBAN1 CELSR1 TLL1 ZNF804B DNAAF1	3.22e-05	165	98	5	0c714e852f912b5749de4cb0895406673979b2e6
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NIBAN1 CELSR1 TLL1 ZNF804B DNAAF1	3.22e-05	165	98	5	82530f96aaefe28a13bad0474bbad043f127a86c
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	RREB1 ADARB2 LMX1A TLL1 TMEM26	3.31e-05	166	98	5	6a6ed5c7a43fee9a8a9be42dfa99303815b8e8ef
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-4\|TCGA-Lung / Sample_Type by Project: Shred V9	COL4A1 ADAMTS2 ADAMTS14 TMEM26 PCOLCE	3.51e-05	168	98	5	aefea14b8b1c1b6a05f827effd22ba15274fddc9
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Airway_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	PAPPA2 ADAMTS2 ZIM2 ZC2HC1C ITGBL1	4.03e-05	173	98	5	b23b408acc29a667cce104429afef1a6cf2720a5
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|390C / Donor, Lineage, Cell class and subclass (all cells)	LAMP5 CSMD2 ITGBL1 TENM1 PCOLCE	4.38e-05	176	98	5	852d3da0907fe87c0ef23d75a63ce07619cf0c54
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	LAMP5 CSMD2 ITGBL1 TENM1 PCOLCE	4.38e-05	176	98	5	d2df1e435996c51213e88270af9f928e9e09a6f5
ToppCell	5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL4A1 ADAMTS3 STARD9 TENM1 TMEM26	4.50e-05	177	98	5	e65c0568dc5852108e9802273499bc7cf88fafab
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	COL4A1 LAMP5 ADARB2 SLCO5A1 TMEM26	4.50e-05	177	98	5	b75f519d72611b293d9684f7dcfb1b70fbf54a90
ToppCell	cellseq2-Mesenchymal-Myocytic-Myocytic_1-Pericyte\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL4A1 ADAMTS2 MTMR1 STARD9 CD163L1	4.50e-05	177	98	5	68263456a3c93cd195b321b309ff59e156d732fe
ToppCell	cellseq2-Mesenchymal-Myocytic-Myocytic_1\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL4A1 ADAMTS2 MTMR1 STARD9 CD163L1	4.50e-05	177	98	5	e415e448c37adc102d766235e9953dec32c021f1
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)-Glut_ET_L5_FEZF2-Exc_L5_FEZF2_MORN2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS2 RREB1 PTER PCSK6 DNAAF1	4.62e-05	178	98	5	b0fc56f583cb3f2977fe2306994c0d478c9a6b1b
ToppCell	Adult-Epithelial-club_cell-D122\|Adult / Lineage, Cell type, age group and donor	NIBAN1 FRAS1 CELSR1 TLL1 UTY	4.62e-05	178	98	5	35a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK5 HNF1B ERVMER34-1 ADARB2 ADAMTS14	4.75e-05	179	98	5	55bc69f107fc710db7617c428575792adfdbbcc1
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	MTMR1 CELSR1 PCSK6 KIF14 AFF1	4.87e-05	180	98	5	12f3c4c4aa7fe03c0ef847bd4d4942c808015f5f
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_ILC-NK_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	MTMR1 CELSR1 PCSK6 KIF14 AFF1	4.87e-05	180	98	5	1bc01bb76d0d3f8db74f9244436d3e6d6015ed5d
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_ILC\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	MTMR1 CELSR1 PCSK6 KIF14 AFF1	4.87e-05	180	98	5	2a28fbfe10a340c8662c2c8be33792f41fc09088
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAPPA2 FRAS1 ADAMTS3 DBNL SLCO5A1	5.00e-05	181	98	5	7af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTER CD163L1 TLL1 HERC3 TMEM26	5.55e-05	185	98	5	bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 FZD1 ITGBL1 PCSK6 PCOLCE	5.69e-05	186	98	5	35c88cc4eb388811fcac4323b549e5897fa8dc27
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	DPP6 FRAS1 LAMP5 FZD1 ZNF804B	5.69e-05	186	98	5	8915436d09775f2828a7678af203b1082b36e21c
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 FZD1 ITGBL1 PCSK6 PCOLCE	5.69e-05	186	98	5	d998c5b00083cf2a7cd5341a98b7374b4de73c63
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTS2 PTER ITGBL1 OTUD7A PCOLCE	5.69e-05	186	98	5	827f2f2ddde315d1e5970dd56f906c555ec699af
ToppCell	10x3'2.3-week_12-13-Mesenchymal_adipo\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FRAS1 ADAMTS2 FZD1 SLC17A7 PCOLCE	5.84e-05	187	98	5	f1d0fc625e0e7881b3f290742fd7148d995eb71e
ToppCell	10x3'2.3-week_12-13-Mesenchymal_adipo-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FRAS1 ADAMTS2 FZD1 SLC17A7 PCOLCE	5.84e-05	187	98	5	02e7246ef5ad41773d14426254e139b156d45c1d
ToppCell	10x3'2.3-week_12-13-Mesenchymal_adipo-stroma-adipo-CAR\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FRAS1 ADAMTS2 FZD1 SLC17A7 PCOLCE	5.84e-05	187	98	5	08c73d125e0638c9e9878165bba2442c266c8a48
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	COL4A1 ERVMER34-1 ADARB2 STARD9 ADAMTSL2	5.99e-05	188	98	5	ccddc08121caff958a2b6f9e278a018858af6b4d
ToppCell	PCW_10-12-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MYCL NIBAN1 FZD6 CELSR1 ZNF804B	5.99e-05	188	98	5	3cfba3addcc9058f4ec31ad96261f79988f551a0
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTS2 ADAMTS8 SCUBE2 ADAMTSL2 PCOLCE	6.14e-05	189	98	5	40cbd679dc0548bf5207e1b033c0597886ad6fe1
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	COL4A1 ADARB2 ADAMTS14 TMEM26 ADAMTSL2	6.14e-05	189	98	5	f75cebd4c3e54e297557449ba67ccc8d1a2a14f5
ToppCell	(2)_Fibroblasts-(22)_Fibro-3\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	PCSK5 DSC2 ITGBL1 SCUBE2 PCOLCE	6.30e-05	190	98	5	3aed03b87ba2c8d479048c3ceef3ff5e38746c28
ToppCell	Adult-Epithelial-club_cell\|Adult / Lineage, Cell type, age group and donor	NIBAN1 FRAS1 CELSR1 SCUBE2 TLL1	6.30e-05	190	98	5	756bff697d30aec56c0ebfca94295f084a15bf37
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NIBAN1 FRAS1 CELSR1 TLL1 ZNF804B	6.45e-05	191	98	5	60ff989fe99d243a3d52955223680cdd1f1917a4
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 ADAMTS2 FZD1 PCSK6 PCOLCE	6.45e-05	191	98	5	9214655dca96d766737c9f30b624d7fe7050342e
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTS2 ADAMTS8 FZD1 SCUBE2 PCOLCE	6.45e-05	191	98	5	8a73d2df079566fca4cbb5cdb85721c2e87134c8
ToppCell	Children_(3_yrs)-Epithelial-club_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NIBAN1 FRAS1 CELSR1 SCUBE2 TLL1	6.45e-05	191	98	5	23776c7302cead3881b39127398f3b3e0d27885e
ToppCell	ASK440-Mesenchymal\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	ADAMTS2 ADAMTS8 ITGBL1 TENM1 PCOLCE	6.45e-05	191	98	5	f12959eebb4167e1aa03de05d7711a702c58b3c9
ToppCell	metastatic_Lymph_Node-Fibroblasts-Myofibroblasts\|metastatic_Lymph_Node / Location, Cell class and cell subclass	COL4A1 ADAMTS2 ITGBL1 ADAMTSL2 PCOLCE	6.45e-05	191	98	5	aa43b472bc8362f79ae63f09f1ca764718bbf22c
ToppCell	ASK440-Mesenchymal-Fibroblast\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	ADAMTS2 ADAMTS8 ITGBL1 TENM1 PCOLCE	6.45e-05	191	98	5	387296b5377ef6839f0812e5b3529a10b5f7d530
ToppCell	droplet-Lung-21m-Mesenchymal\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTS2 ADAMTS8 FZD1 SCUBE2 PCOLCE	6.45e-05	191	98	5	10a9db1caa0fdb51ace8537f42b2c66f7c97e0f5
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Early_airway_SMC_1\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	COL4A1 PCSK5 ITGBL1 ADAMTS14 ADAMTSL2	6.61e-05	192	98	5	7ae3e1ca8bfc078c0e12a1595ecb0e343dab5d2f
ToppCell	facs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 ITGBL1 PCSK6 ADAMTSL2 PCOLCE	6.61e-05	192	98	5	671d4e1eee5aba03c43dbc98f4b51ce42b3df5d5
ToppCell	PND14-Mesenchymal-Mesenchymal_structural\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS2 PCDHGA9 SCUBE2 ADAMTSL2 PCOLCE	6.61e-05	192	98	5	25492568f9cbe097b7bb1db50d8b817c80ea87d7
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS3 ADAMTS2 ADAMTS8 SCUBE2 PCOLCE	6.61e-05	192	98	5	dcd924d6eb67d33ee9f5d3e8ab6e1d4283d6b708
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS2 PCDHGA9 SCUBE2 ADAMTSL2 PCOLCE	6.61e-05	192	98	5	de9c1536d5aee86f9c62acbc54ca8fa581c00f17
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL4A1 ADAMTS2 ADAMTS8 SCUBE2 PCOLCE	6.61e-05	192	98	5	ee085e04d5dcfb657522484ed20b8c1ddeccfe0c
ToppCell	facs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS2 ITGBL1 PCSK6 ADAMTSL2 PCOLCE	6.61e-05	192	98	5	840a34c1b82d218be999ab5e1bcafd6370d7a4b1
ToppCell	10x5'v1-week_12-13-Mesenchymal_adipo-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FRAS1 ADAMTS2 FZD1 ITGBL1 TLL1	6.78e-05	193	98	5	cf2461af78f65616ce40d552ee9452295e3895ed
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A1 ADAMTS2 ITGBL1 ADAMTSL2 PCOLCE	6.78e-05	193	98	5	dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCell	droplet-Limb_Muscle-nan-18m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A1 ADAMTS2 ITGBL1 PCSK6 PCOLCE	6.78e-05	193	98	5	49600db68ed65cafc67bd45a285b364e4f5f88af
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS2 ADAMTS8 SCUBE2 ADAMTSL2 PCOLCE	6.78e-05	193	98	5	4c74a3f69b2cbdf139e7e66b44bd86869ac34dc0
ToppCell	Epithelial-club_cell\|World / Lineage, Cell type, age group and donor	NIBAN1 FRAS1 CELSR1 SCUBE2 TLL1	6.78e-05	193	98	5	2bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ADAMTS2 ADAMTS8 SCUBE2 ADAMTSL2 PCOLCE	6.78e-05	193	98	5	ff8ceeb3cfd1bef7239df490c19d181091750833
ToppCell	10x5'v1-week_12-13-Mesenchymal_adipo\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FRAS1 ADAMTS2 FZD1 ITGBL1 TLL1	6.78e-05	193	98	5	6ef9007c9d18fb775d08fb20cdf954a28d54d7eb
ToppCell	10x3'2.3-week_14-16-Mesenchymal_fibro-stroma-arteriolar_fibroblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ADAMTS8 LMX1A TLL1 SLC17A7 TMEM26	6.78e-05	193	98	5	09de51f8ac509e03d480ed3dc9dfe7e7defc59cb
ToppCell	PCW_05-06-Epithelial-Epithelial_airway\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	HNF1B NIBAN1 FZD6 CELSR1 TLL1	6.78e-05	193	98	5	af6ec2c2ba92aef3e41531c3c7215b3300437bd9
ToppCell	10x5'v1-week_12-13-Mesenchymal_adipo-stroma-adipo-CAR\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	FRAS1 ADAMTS2 FZD1 ITGBL1 TLL1	6.78e-05	193	98	5	e4ea7ce011a80b81b841c907719aa532bed39d2e
ToppCell	droplet-Limb_Muscle-nan-18m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A1 ADAMTS2 ITGBL1 PCSK6 PCOLCE	6.78e-05	193	98	5	45b5cab4dfeb0ed3b13631db5963740a792b810f
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A1 ADAMTS2 ITGBL1 ADAMTSL2 PCOLCE	6.78e-05	193	98	5	e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCell	facs-BAT-Fat-3m-Mesenchymal-mesenchymal_progenitor\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 CTSF ADAMTS2 ITGBL1 PCOLCE	6.95e-05	194	98	5	da45811ba07d746e7cba7ed78882b5d98ac7397d
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS3 ADAMTS2 ADAMTS8 SCUBE2 PCOLCE	6.95e-05	194	98	5	60622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCell	facs-BAT-Fat-3m-Mesenchymal\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 CTSF ADAMTS2 ITGBL1 PCOLCE	6.95e-05	194	98	5	76b8512fd92014b3ecc42b0a20d6d1df074cba2c
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor2_(4)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HNF1B NIBAN1 CELSR1 TLL1 ZNF804B	6.95e-05	194	98	5	6b286992d4bb56013c0ea5a7601d3476d806175a
ToppCell	PCW_05-06-Epithelial\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	HNF1B NIBAN1 CELSR1 TLL1 NUP210	6.95e-05	194	98	5	47a1369c22fcbfe00b08376eb610a61c355548db
ToppCell	facs-BAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCSK5 CTSF ADAMTS2 ITGBL1 PCOLCE	6.95e-05	194	98	5	ef0fa9daecd3bf43c6cf56345928cacdbee19779
ToppCell	(1)_Osterolineage_cells-(11)_OLC-2\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	NIBAN1 ADAMTS2 FZD1 ITGBL1 PCOLCE	7.12e-05	195	98	5	78978d85273e5463a7f43e4c121e647fa6aba42b
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAMTS2 ADAMTS8 ITGBL1 ADAMTSL2 PCOLCE	7.29e-05	196	98	5	9737a5f006d37b549f281e1863aca558e1e4dc99
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAMTS2 ADAMTS8 ITGBL1 ADAMTSL2 PCOLCE	7.29e-05	196	98	5	cecf82cd5e0a3835d655f5e7478578674a63ce25
ToppCell	normal_Lung-Fibroblasts-COL13A1+_matrix_FBs\|normal_Lung / Location, Cell class and cell subclass	ADAMTS8 FZD1 ITGBL1 ADAMTSL2 PCOLCE	7.47e-05	197	98	5	6c57ab2efb8363828e24211c4d45e58bb73a9a4d
ToppCell	10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_COL\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	COL4A1 ADAMTS2 LAMP5 ITGBL1 PCOLCE	7.65e-05	198	98	5	8b9e8eaeffda40912a0163fdf39b93bc5e64751c
ToppCell	tumor_Lung-Fibroblasts-COL13A1+_matrix_FBs\|tumor_Lung / Location, Cell class and cell subclass	CTSF ADAMTS8 ITGBL1 ADAMTSL2 PCOLCE	7.65e-05	198	98	5	2d7842f352273b6b823c86eb548b9f4a4cddf0ae
Disease	Primary microcephaly	DPP6 PHC1 TUBGCP3	4.61e-05	22	94	3	C0431350
Disease	lateral ventricle volume measurement	COL4A1 SLCO5A1 ZNF804B	1.59e-04	33	94	3	EFO_0008487
Disease	cholesteryl esters to total lipids in small HDL percentage	ZPR1 PCSK6 AFF1	3.52e-04	43	94	3	EFO_0022254
Disease	centronuclear myopathy X-linked (implicated_via_orthology)	MTMR1 MTMR3	3.56e-04	9	94	2	DOID:0111225 (implicated_via_orthology)
Disease	triglyceride measurement, intermediate density lipoprotein measurement	ZPR1 PCSK7 AFF1 PPP6R2	4.46e-04	111	94	4	EFO_0004530, EFO_0008595
Disease	body fat distribution	PCSK5 ADAMTS3 ADAMTS2 ADARB2 ADAMTS14	4.79e-04	202	94	5	EFO_0004341
Disease	cholesterol to total lipids in small HDL percentage	ZPR1 PCSK6 AFF1	5.84e-04	51	94	3	EFO_0022240
Disease	cholesterol to total lipids in large HDL percentage	MADD ZPR1 AFF1	7.28e-04	55	94	3	EFO_0022234
Disease	phospholipids:total lipids ratio	MADD ZPR1 PCSK6 PCSK7 AFF1	8.12e-04	227	94	5	EFO_0020946
Disease	total brain volume change measurement	DPP6 LMX1A	8.91e-04	14	94	2	EFO_0021504
Disease	cholesteryl esters to total lipids in large HDL percentage	MADD ZPR1 AFF1	8.94e-04	59	94	3	EFO_0022248
Disease	triglycerides to total lipids in large HDL percentage	MADD ZPR1 AFF1	9.39e-04	60	94	3	EFO_0022330
Disease	cholesterol to total lipids in medium HDL percentage	ZPR1 PCSK7 AFF1	9.39e-04	60	94	3	EFO_0022237
Disease	cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement	MADD ZPR1 PCSK6 PCSK7 AFF1	1.10e-03	243	94	5	EFO_0004612, EFO_0020944
Disease	ureidopropionic acid measurement	ADARB2 OTOG	1.17e-03	16	94	2	EFO_0010542
Disease	intraocular pressure measurement	COL4A1 PCSK5 ADAMTS2 ADAMTS8 TLL1 HERC2 TMEM26	1.23e-03	509	94	7	EFO_0004695
Disease	triglycerides to phosphoglycerides ratio	ZPR1 PCSK7 AFF1	1.35e-03	68	94	3	EFO_0022327
Disease	triglycerides:total lipids ratio, low density lipoprotein cholesterol measurement	ZPR1 PCSK6 PCSK7 AFF1	1.37e-03	150	94	4	EFO_0004611, EFO_0020947
Disease	unipolar depression, bipolar disorder, schizophrenia	PCSK5 ADAMTS2	1.84e-03	20	94	2	EFO_0003761, MONDO_0004985, MONDO_0005090
Disease	urinary bladder cancer (is_implicated_in)	CASP9 CDC25A PMF1	1.86e-03	76	94	3	DOID:11054 (is_implicated_in)
Disease	cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	MADD ZPR1 PCSK6 PCSK7 AFF1	1.92e-03	276	94	5	EFO_0004612, EFO_0020943
Disease	Corneal astigmatism	ADAMTS8 MADD HERC2	1.93e-03	77	94	3	EFO_1002040
Disease	Lung diseases	PCSK5 HPS4 DNAAF1	2.00e-03	78	94	3	C0024115
Disease	non-high density lipoprotein cholesterol measurement	PCSK5 ZNF266 ADAMTS3 PHC1 CD163L1 ZPR1 AFF1 PPP6R2	2.01e-03	713	94	8	EFO_0005689
Disease	dilated cardiomyopathy (biomarker_via_orthology)	DSC2 CASP9	2.23e-03	22	94	2	DOID:12930 (biomarker_via_orthology)
Disease	Autosomal Recessive Primary Microcephaly	PHC1 KIF14	2.23e-03	22	94	2	C3711387
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	MTMR1 MTMR3	2.65e-03	24	94	2	DOID:10595 (implicated_via_orthology)
Disease	phospholipids:total lipids ratio, high density lipoprotein cholesterol measurement	MADD ZPR1 PCSK6 PCSK7 AFF1	3.05e-03	307	94	5	EFO_0004612, EFO_0020946
Disease	dental caries	ADAMTS3 ADAMTS2 FZD1 ZNF804B	3.06e-03	187	94	4	EFO_0003819
Disease	amygdala volume change measurement, age at assessment	ADARB2 FZD6	3.10e-03	26	94	2	EFO_0008007, EFO_0021490

Protein segments in the cluster

Peptide	Gene	Start	Entry
SCQEGFSLKGGSEHR	CSMD2	3216	Q7Z408
TCGGGVQFSHRECKD	ADAMTS8	541	Q9UP79
KGCGGGTHSSDRNQA	CFAP418	31	Q96NL8
GSVGNAVRHCSGEKG	CELSR1	2081	Q9NYQ6
SRGIGSHCKSEGQEE	DCAF6	506	Q58WW2
SGAKCDAQTHGGATA	ANKRD39	86	Q53RE8
GQSDCGHKEDAGVRC	CD163L1	1331	Q9NR16
GHKEDAGVRCSGQSL	CD163L1	1336	Q9NR16
DGEAAGLSCRVKHSS	CD1B	271	P29016
MVKGGHQTSESCRGA	DSC2	786	Q02487
CGGDNSHCRTVKGTL	ADAMTS14	706	Q8WXS8
GGDNSHCKVVKGTFT	ADAMTS2	716	O95450
EHSRAAAKGGCAGSG	COL4A1	21	P02462
RVEKIGAQSHGDNSC	MTMR1	156	Q13613
TSGTEHQFCGGRLEK	PCOLCE	151	Q15113
SGTKCISGEHLSDQG	ADARB2	411	Q9NS39
GSEHCSGIRVKAEAQ	NUP210	601	Q8TEM1
ADDHCTIKNFGGTVS	KIF14	846	Q15058
CESGSEGDGTVHRRK	JMJD6	361	Q6NYC1
HVLRDGGCESSCGKG	FRAS1	536	Q86XX4
GKEGESDRRHSKGCN	LIN54	586	Q6MZP7
SRGKEGTHATCASEE	MADD	116	Q8WXG6
SGGKHCLALSSEGEV	HERC2	4046	O95714
ISDRSVKEVACGGNH	HERC3	31	Q15034
RCADASITNDKGHDG	ERVMER34-1	261	Q9H9K5
GRKENGCLSGHDLES	HPS4	321	Q9NQG7
NCAEERDAHNGSVGK	CCDC88C	1466	Q9P219
ASNENKHGTRCAGEV	PCSK5	206	Q92824
KHGTRCAGEVAAAAN	PCSK5	211	Q92824
SGNGGRSKDHCSCDG	PCSK5	311	Q92824
SNENKHGTRCAGEVA	PCSK6	241	P29122
DLQKGTGCTEGHTGT	PCSK7	391	Q16549
DHSGGIGDICKSINN	LACTB2	81	Q53H82
EESLCKSAHGAGKGT	LMX1A	171	Q8TE12
AHDRDSGKNGQVVCS	PCDHGA9	371	Q9Y5G4
SANLGSGCEEKRHEG	PMF1	6	Q6P1K2
STHTLDKCGICQGDG	ADAMTSL2	196	Q86TH1
RGAEVKGRCGHSQSE	LAMP5	91	Q9UJQ1
DHCQGRKGGELASAV	TUBGCP3	386	Q96CW5
GAAGTAGAAEHKSQT	OTUD7A	836	Q8TE49
RKTSEHSQGCGTGGQ	GPR42	326	O15529
NEILHGADGTSIKCG	PTER	151	Q96BW5
AGVFDNCSHTVSDKG	PAPPA2	306	Q9BXP8
HGAGELCVGQNTSDK	FZD1	221	Q9UP38
VSGVRKEQGGGCHSD	FZD6	691	O60353
GGDNSHCRTVKGTFT	ADAMTS3	706	O15072
ACGGEQKDHGFEVAS	CASP9	286	P55211
AKGNTALHDCAESGS	FEM1A	181	Q9BSK4
RKTSEHSQGCGTGGQ	FFAR3	326	O14843
HRGSGACGVNTMASS	CTSF	466	Q9UBX1
ESSKGSHRTGGQCHL	CEP350	2006	Q5VT06
DTGQCGGSIDHRSSS	ANKMY1	416	Q9P2S6
HGSAGRGGCKEEIND	DNAAF1	31	Q8NEP3
SSHGAVVVKCDGRGS	DPP6	651	P42658
GGCDRTCKDTSTGVH	SCUBE2	291	Q9NQ36
ESADGILCSGKGSCH	ITGBL1	416	O95965
GEGVNDVRKGACASH	DBNL	86	Q9UJU6
ECSHAEGSRSQGPEK	PPP6R2	776	O75170
SRGCLHSHGLQEGKD	CDC25A	156	P30304
GHCANGEAGRSKDSL	MTMR3	956	Q13615
QAVSSGHTRCEKGAD	nan	121	A6NNC1
AVSSGHRCENKAGTA	nan	436	A6NNC1
SGHRCENKAGTAPGQ	nan	711	A6NNC1
EASKTSKAQGHGLCG	OTOG	2236	Q6ZRI0
KDSDCHAGEAVTAGN	P2RX5	131	Q93086
TNGHAKGRLSGDEGS	HNF1B	66	P35680
RHTGDTSNGCADVKG	UTY	681	O14607
RSQSEGLKGEHGCRA	TMEM26	316	Q6ZUK4
GLKGEHGCRAQTSES	TMEM26	321	Q6ZUK4
AHGKDCNGSLDTSQG	SCN4A	501	P35499
RKGFQATHSTECGGR	TLL1	876	O43897
ATHSTECGGRLKAES	TLL1	881	O43897
FGCVDSSGHQELKQG	SLCO5A1	61	Q9H2Y9
LCGSSESRGVNESHK	SETD4	16	Q9NVD3
QSHCGDGGRASEASL	TENM1	1291	Q9UKZ4
AVGSGHRKQAASQEG	MUTYH	21	Q9UIF7
EKCGFVGHDQLAGSD	SLC17A7	506	Q9P2U7
GAEGKFAVTCHDRTA	WHAMM	36	Q8TF30
GSGLTEVCRAGSKHS	STARD9	2881	Q9P2P6
TCKDSGHAGARDIVS	POLA2	81	Q14181
KGDRRADGDHCASVT	AFF1	176	P51825
CGHRTNEVKSGGAVE	ZPR1	291	O75312
VHTGERHECGQCGKS	ZNF586	311	Q9NXT0
CTVGGHSDHGKDFSV	ZNF804B	661	A4D1E1
HVGERNFTCTQGGKD	ZNF749	146	O43361
GGCTGDEAESRGHSK	MYCL	66	P12524
TLTAHEGRGGKCTEE	NIBAN1	821	Q9BZQ8
DRLGKHDVTCTVSGG	MRPS9	321	P82933
GGVGSDTVHKCAEAG	RPEL1	176	Q2QD12
DTGGADHSCSICGKS	RREB1	91	Q92766
GGIHTADTKTAGSVC	RTCA	86	O00442
HCTGATDGATADKIQ	VPS16	816	Q9H269
GNGLECFEKSGHCTA	PPAT	491	Q06203
QGKCHRGQEDSSRGS	PHC1	871	P78364
CEQELGFKGHTSGVS	WDR53	231	Q7Z5U6
HRKSCSTGEAGTDGD	ZC2HC1C	146	Q53FD0
KTHSGRKTSGCNEGR	ZIM2	376	Q9NZV7
TGALATCAGHEDKAG	ZBTB32	341	Q9Y2Y4
LHQGKGNESDCRSGR	ZSCAN29	601	Q8IWY8
DRAAGDGDCGTTHSR	TKFC	396	Q3LXA3
CGGTSNKHSLEEDEG	TXLNG	71	Q9NUQ3
RVHNGETTFKCDGCG	ZNF284	391	Q2VY69
QGSSKGNHLCGSELD	ZNF554	236	Q86TJ5
SHNGGEVSDVKQCGD	ZNF266	71	Q14584
KACTSASDEATGQGH	GARIN5B	296	Q8N5Q1
GESCHGCSEQITKGL	LIMK1	81	P53667