Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium channel activity	SCN11A HCN3 MCOLN1 NALCN SCN8A MCOLN3	8.59e-06	52	186	6	GO:0005272
GeneOntologyMolecularFunction	netrin receptor activity	DCC UNC5C UNC5D	1.56e-05	6	186	3	GO:0005042
GeneOntologyMolecularFunction	isopentenyl-diphosphate delta-isomerase activity	IDI2 IDI1	8.63e-05	2	186	2	GO:0004452
GeneOntologyMolecularFunction	sulfate:bicarbonate antiporter activity	SLC26A1 SLC26A6	8.63e-05	2	186	2	GO:0015383
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN11A HCN3 NALCN SCN8A	9.28e-05	26	186	4	GO:0005248
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	MCOLN1 ITPR3 TRPM8 MCOLN3	1.88e-04	31	186	4	GO:0099604
GeneOntologyMolecularFunction	calcium channel activity	PKD1L2 MCOLN1 ITPR3 CACNG2 PKD1 TRPM8 MCOLN3	2.09e-04	129	186	7	GO:0005262
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	HCN3 MCOLN1 ITPR3 MCOLN3	2.41e-04	33	186	4	GO:0005217
GeneOntologyMolecularFunction	glucagon receptor activity	GCGR GLP2R	2.57e-04	3	186	2	GO:0004967
GeneOntologyMolecularFunction	monoatomic ion channel activity	SCN11A HCN3 PKD1L2 MCOLN1 ITPR3 CACNG2 TMEM120A NALCN PKD1 SCN8A TRPM8 SLC26A6 MCOLN3	3.84e-04	459	186	13	GO:0005216
GeneOntologyMolecularFunction	monoatomic cation channel activity	SCN11A HCN3 PKD1L2 MCOLN1 ITPR3 CACNG2 NALCN PKD1 SCN8A TRPM8 MCOLN3	3.87e-04	343	186	11	GO:0005261
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	PKD1L2 MCOLN1 ITPR3 CACNG2 PKD1 TRPM8 MCOLN3	5.43e-04	151	186	7	GO:0015085
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	MCOLN1 ITPR3 MCOLN3	5.85e-04	18	186	3	GO:0015278
GeneOntologyMolecularFunction	NAADP-sensitive calcium-release channel activity	MCOLN1 MCOLN3	8.47e-04	5	186	2	GO:0072345
GeneOntologyMolecularFunction	channel activity	SCN11A HCN3 PKD1L2 MCOLN1 ITPR3 CACNG2 TMEM120A NALCN PKD1 SCN8A TRPM8 SLC26A6 MCOLN3	1.32e-03	525	186	13	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	SCN11A HCN3 PKD1L2 MCOLN1 ITPR3 CACNG2 TMEM120A NALCN PKD1 SCN8A TRPM8 SLC26A6 MCOLN3	1.35e-03	526	186	13	GO:0022803
Domain	PKD_channel	PKD1L2 MCOLN1 PKD1 MCOLN3	2.79e-06	11	183	4	PF08016
Domain	PKD1_2_channel	PKD1L2 MCOLN1 PKD1 MCOLN3	2.79e-06	11	183	4	IPR013122
Domain	Ion_trans_dom	SCN11A HCN3 MCOLN1 ITPR3 NALCN SCN8A TRPM8 MCOLN3	1.66e-05	114	183	8	IPR005821
Domain	Ion_trans	SCN11A HCN3 MCOLN1 ITPR3 NALCN SCN8A TRPM8 MCOLN3	1.66e-05	114	183	8	PF00520
Domain	LRR	LRRN1 LRRTM3 LRRTM1 TLR9 LGI3 SLIT1 LRRTM4 LRRTM2 PKD1 NXF5	3.00e-05	201	183	10	PS51450
Domain	LRR_8	LRRN1 LRRTM3 LRRTM1 TLR9 LGI3 SLIT1 LRRTM4 LRRTM2 PKD1	4.88e-05	171	183	9	PF13855
Domain	LRRNT	LRRN1 LRRTM3 LRRTM1 SLIT1 LRRTM4 LRRTM2 PKD1	5.05e-05	98	183	7	IPR000372
Domain	LRRNT	LRRN1 LRRTM3 LRRTM1 SLIT1 LRRTM4 LRRTM2 PKD1	5.05e-05	98	183	7	SM00013
Domain	LRR_TYP	LRRN1 LRRTM3 LRRTM1 TLR9 LGI3 SLIT1 LRRTM4 LRRTM2 PKD1	6.37e-05	177	183	9	SM00369
Domain	Leu-rich_rpt_typical-subtyp	LRRN1 LRRTM3 LRRTM1 TLR9 LGI3 SLIT1 LRRTM4 LRRTM2 PKD1	6.37e-05	177	183	9	IPR003591
Domain	Leu-rich_rpt	LRRN1 LRRTM3 LRRTM1 TLR9 FBXL5 LGI3 SLIT1 LRRTM4 LRRTM2 PKD1 NXF5	7.71e-05	271	183	11	IPR001611
Domain	IsopentenylPP_isomerase_typ1	IDI2 IDI1	9.55e-05	2	183	2	IPR011876
Domain	Phe_ZIP	SH2B2 SH2B1	2.85e-04	3	183	2	PF08916
Domain	Phe_ZIP	SH2B2 SH2B1	2.85e-04	3	183	2	IPR015012
Domain	SH2B	SH2B2 SH2B1	2.85e-04	3	183	2	IPR030523
Domain	LRR_1	LRRN1 LRRTM3 LRRTM1 TLR9 FBXL5 LGI3 SLIT1 LRRTM4 LRRTM2	3.17e-04	219	183	9	PF00560
Domain	-	LRRN1 LRRTM3 LRRTM1 TLR9 FBXL5 LGI3 SLIT1 LRRTM4 LRRTM2 PKD1 NXF5	3.37e-04	321	183	11	3.80.10.10
Domain	ARM-like	GPRASP1 USP9X DOCK10 ARFGEF2 ARFGEF1 HEATR1 USP9Y RIF1 PSME4 NIPBL	3.41e-04	270	183	10	IPR011989
Domain	L_dom-like	LRRN1 LRRTM3 LRRTM1 TLR9 FBXL5 LGI3 SLIT1 LRRTM4 LRRTM2 PKD1 NXF5	4.04e-04	328	183	11	IPR032675
Domain	ARM-type_fold	GPRASP1 DOCK11 USP9X ARFGEF2 ARFGEF1 NCBP1 HEATR1 USP9Y RIF1 PSME4 NIPBL	5.32e-04	339	183	11	IPR016024
Domain	DCB_dom	ARFGEF2 ARFGEF1	5.66e-04	4	183	2	IPR032629
Domain	Sec7_C	ARFGEF2 ARFGEF1	5.66e-04	4	183	2	IPR015403
Domain	DUF1981	ARFGEF2 ARFGEF1	5.66e-04	4	183	2	PF09324
Domain	Sec7_N	ARFGEF2 ARFGEF1	5.66e-04	4	183	2	IPR032691
Domain	Sec7_N	ARFGEF2 ARFGEF1	5.66e-04	4	183	2	PF12783
Domain	REJ	PKD1L2 PKD1	5.66e-04	4	183	2	PS51111
Domain	REJ_dom	PKD1L2 PKD1	5.66e-04	4	183	2	IPR014010
Domain	DCB	ARFGEF2 ARFGEF1	5.66e-04	4	183	2	PF16213
Domain	Gal_mutarotase_SF_dom	MAN2B1 LGI3 MGAM2	5.69e-04	17	183	3	IPR011013
Domain	LH2	PNLIPRP2 PKD1L2 PKD1	6.78e-04	18	183	3	SM00308
Domain	Anaphylatoxin_comp_syst	C4A C4B	9.36e-04	5	183	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	9.36e-04	5	183	2	IPR001840
Domain	Sterol-sensing	HMGCR PTCH2	9.36e-04	5	183	2	PF12349
Domain	UPA	UNC5C UNC5D	9.36e-04	5	183	2	PF17217
Domain	UPA	UNC5C UNC5D	9.36e-04	5	183	2	IPR033772
Domain	-	PNLIPRP2 PKD1L2 PKD1	1.08e-03	21	183	3	2.60.60.20
Domain	PLAT	PNLIPRP2 PKD1L2 PKD1	1.08e-03	21	183	3	PF01477
Domain	PLAT/LH2_dom	PNLIPRP2 PKD1L2 PKD1	1.08e-03	21	183	3	IPR001024
Domain	PLAT	PNLIPRP2 PKD1L2 PKD1	1.08e-03	21	183	3	PS50095
Domain	DUF3398	DOCK11 DOCK10	1.40e-03	6	183	2	PF11878
Domain	PKD/REJ-like	PKD1L2 PKD1	1.40e-03	6	183	2	IPR002859
Domain	REJ	PKD1L2 PKD1	1.40e-03	6	183	2	PF02010
Domain	DOCK_C/D_N	DOCK11 DOCK10	1.40e-03	6	183	2	IPR021816
Domain	-	GPRASP1 USP9X ARFGEF2 ARFGEF1 HEATR1 RIF1 PSME4 NIPBL	1.59e-03	222	183	8	1.25.10.10
Domain	ANATO	C4A C4B	1.94e-03	7	183	2	SM00104
Domain	Clathrin	WDR19 TGFBRAP1	1.94e-03	7	183	2	PF00637
Domain	S04_transporter_CS	SLC26A1 SLC26A6	1.94e-03	7	183	2	IPR018045
Domain	ANAPHYLATOXIN_2	C4A C4B	1.94e-03	7	183	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	1.94e-03	7	183	2	PS01177
Domain	ANATO	C4A C4B	1.94e-03	7	183	2	PF01821
Domain	Anaphylatoxin/fibulin	C4A C4B	1.94e-03	7	183	2	IPR000020
Domain	FHA	KIF1B PPP1R8 FHAD1	2.53e-03	28	183	3	SM00240
Domain	Clathrin_H-chain/VPS_repeat	WDR19 TGFBRAP1	2.57e-03	8	183	2	IPR000547
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	2.57e-03	8	183	2	IPR019565
Domain	Thiol-ester_cl	C4A C4B	2.57e-03	8	183	2	PF10569
Domain	MacrogloblnA2_CS	C4A C4B	2.57e-03	8	183	2	IPR019742
Domain	-	ZNF449 ZXDC ZNF146 ZNF354A ZNF154 ZNF112 ZNF354B ZNF850 ZNF692 ZNF529 ZNF169 ZFPM2 ZNF594 ZNF526 ZNF616	2.87e-03	679	183	15	3.30.160.60
Domain	ZU5	UNC5C UNC5D	3.29e-03	9	183	2	SM00218
Domain	zf-C2H2_11	ZNF354A ZNF354B	3.29e-03	9	183	2	PF16622
Domain	FHA_DOMAIN	KIF1B PPP1R8 FHAD1	3.40e-03	31	183	3	PS50006
Domain	FHA	KIF1B PPP1R8 FHAD1	3.40e-03	31	183	3	PF00498
Domain	Znf_C2H2/integrase_DNA-bd	ZNF449 ZXDC ZNF146 ZNF354A ZNF154 ZNF112 ZNF354B ZNF850 ZNF692 ZNF529 ZNF169 ZFPM2 ZNF594 ZNF526 ZNF616	3.52e-03	694	183	15	IPR013087
Domain	LRRCT	LRRN1 LGI3 SLIT1	3.72e-03	32	183	3	PF01463
Domain	Na_channel_asu	SCN11A SCN8A	4.08e-03	10	183	2	IPR001696
Domain	A2M	C4A C4B	4.08e-03	10	183	2	PF00207
Domain	Na_trans_assoc	SCN11A SCN8A	4.08e-03	10	183	2	IPR010526
Domain	A2M_N_2	C4A C4B	4.08e-03	10	183	2	IPR011625
Domain	A2M_comp	C4A C4B	4.08e-03	10	183	2	IPR011626
Domain	A2M_recep	C4A C4B	4.08e-03	10	183	2	PF07677
Domain	A2M_comp	C4A C4B	4.08e-03	10	183	2	PF07678
Domain	SLC26A	SLC26A1 SLC26A6	4.08e-03	10	183	2	PS01130
Domain	Na_trans_assoc	SCN11A SCN8A	4.08e-03	10	183	2	PF06512
Domain	A2M_N	C4A C4B	4.08e-03	10	183	2	PF01835
Domain	A2M_N	C4A C4B	4.08e-03	10	183	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	4.08e-03	10	183	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	4.08e-03	10	183	2	PS00477
Domain	ZU5	UNC5C UNC5D	4.08e-03	10	183	2	PS51145
Domain	A2M_N_2	C4A C4B	4.08e-03	10	183	2	PF07703
Domain	Macroglobln_a2	C4A C4B	4.08e-03	10	183	2	IPR001599
Domain	STAS	SLC26A1 SLC26A6	4.95e-03	11	183	2	PS50801
Domain	STAS	SLC26A1 SLC26A6	4.95e-03	11	183	2	PF01740
Domain	SLC26A/SulP_fam	SLC26A1 SLC26A6	4.95e-03	11	183	2	IPR001902
Domain	DHR-1_domain	DOCK11 DOCK10	4.95e-03	11	183	2	IPR027007
Domain	DHR_2	DOCK11 DOCK10	4.95e-03	11	183	2	PS51651
Domain	DHR_1	DOCK11 DOCK10	4.95e-03	11	183	2	PS51650
Domain	DHR-2	DOCK11 DOCK10	4.95e-03	11	183	2	PF06920
Domain	DOCK	DOCK11 DOCK10	4.95e-03	11	183	2	IPR026791
Domain	STAS_dom	SLC26A1 SLC26A6	4.95e-03	11	183	2	IPR002645
Domain	SLC26A/SulP_dom	SLC26A1 SLC26A6	4.95e-03	11	183	2	IPR011547
Domain	DOCK_C	DOCK11 DOCK10	4.95e-03	11	183	2	IPR010703
Domain	DOCK-C2	DOCK11 DOCK10	4.95e-03	11	183	2	PF14429
Domain	DHR-2	DOCK11 DOCK10	4.95e-03	11	183	2	IPR027357
Domain	-	SLC26A1 SLC26A6	4.95e-03	11	183	2	3.30.750.24
Domain	Sulfate_transp	SLC26A1 SLC26A6	4.95e-03	11	183	2	PF00916
Domain	IQ	MYO1A MYO3A SCN8A IQCE	5.20e-03	71	183	4	PF00612
Domain	-	KIF1B PPP1R8 FHAD1	5.21e-03	36	183	3	2.60.200.20
Domain	FHA_dom	KIF1B PPP1R8 FHAD1	5.21e-03	36	183	3	IPR000253
Domain	ZU5	UNC5C UNC5D	5.91e-03	12	183	2	PF00791
Domain	ZU5_dom	UNC5C UNC5D	5.91e-03	12	183	2	IPR000906
Domain	DEATH_DOMAIN	UNC5C IRAK4 UNC5D	6.07e-03	38	183	3	PS50017
Pathway	REACTOME_NEUREXINS_AND_NEUROLIGINS	LRRTM3 LRRTM1 NRXN3 LRRTM4 LRRTM2	1.27e-05	32	136	5	MM15326
Pathway	REACTOME_NETRIN_MEDIATED_REPULSION_SIGNALS	DCC UNC5C UNC5D	4.75e-05	8	136	3	M27328
Pubmed	Developmentally regulated expression of the LRRTM gene family during mid-gestation mouse embryogenesis.	LRRTM3 LRRTM1 LRRTM4 LRRTM2	8.27e-10	4	188	4	16860615
Pubmed	A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system.	LRRTM3 LRRTM1 LRRTM4 LRRTM2	4.12e-09	5	188	4	12676565
Pubmed	Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins.	LRRN1 CLSTN2 LRRTM3 LRRTM1 NRXN3 LRRTM4 LRRTM2	1.31e-08	52	188	7	24613359
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	ZXDC EPHA6 LRRN1 MMP27 PRND LRRTM3 LRRTM1 TLR9 SLC25A25 ZDHHC15 LYPD1 LRP10 DHRS7 LGI3 PGAP1 LRRTM4 PTCH2 TAC3 UNC5D BAIAP2L2	4.51e-07	985	188	20	12975309
Pubmed	Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry.	LRRN1 LRRTM3 LRRTM1	6.19e-07	4	188	3	20678249
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	PKD1L2 MCOLN1 PKD1 TRPM8 MCOLN3	9.18e-07	33	188	5	19834762
Pubmed	An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways.	SCN11A SCN8A TRPM8	3.07e-06	6	188	3	23711479
Pubmed	Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.	PKD1L2 MCOLN1 PKD1 TRPM8 MCOLN3	4.00e-06	44	188	5	19322198
Pubmed	Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation.	DCC UNC5C UNC5D	5.35e-06	7	188	3	12351186
Pubmed	Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents.	DCC UNC5C UNC5D	5.35e-06	7	188	3	20628609
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	RAF1 AARS1 MAN2B1 RALGAPB DOCK10 YTHDC2 FAM111B FANCA PSME4 GSE1 CDK5RAP1 C4A C4B SORL1	1.35e-05	650	188	14	38777146
Pubmed	Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4.	TLR9 IRAK4 IL6	1.81e-05	10	188	3	11923871
Pubmed	Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains.	LRRN1 VN1R17P LRRTM1 LRRTM4	2.03e-05	30	188	4	17273929
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	GPRASP1 AARS1 LARP6 USP9X KIF1B HSPH1 ARFGEF2 NCBP1 USP9Y SH2B1 DHX30 WDR19 WDR3 TMEM168 GUK1 LGI3 PKD1 APPL1 MBD4 NIPBL	2.36e-05	1285	188	20	35914814
Pubmed	Analysis of Netrin 1 receptors during inner ear development.	DCC UNC5C UNC5D	2.48e-05	11	188	3	17616930
Pubmed	Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis.	DCC UNC5C UNC5D	2.48e-05	11	188	3	15186747
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	2.91e-05	2	188	2	19062096
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	2.91e-05	2	188	2	17645767
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	2.91e-05	2	188	2	12207352
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	2.91e-05	2	188	2	27758680
Pubmed	RSK3 is required for concentric myocyte hypertrophy in an activated Raf1 model for Noonan syndrome.	RAF1 RPS6KA2	2.91e-05	2	188	2	26940993
Pubmed	unc5c haploinsufficient phenotype: striking similarities with the dcc haploinsufficiency model.	DCC UNC5C	2.91e-05	2	188	2	23738838
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	2.91e-05	2	188	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	2.91e-05	2	188	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	2.91e-05	2	188	2	4216347
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	2.91e-05	2	188	2	8428773
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	2.91e-05	2	188	2	24638111
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	2.91e-05	2	188	2	21345967
Pubmed	Role of the PXR gene locus in inflammatory bowel diseases.	ABCB1 NR1I2	2.91e-05	2	188	2	17828778
Pubmed	The complement component C4 of mammals.	C4A C4B	2.91e-05	2	188	2	2302180
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	2.91e-05	2	188	2	22151770
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	2.91e-05	2	188	2	29080553
Pubmed	Ubiquitin-specific protease activity of USP9Y, a male infertility gene on the Y chromosome.	USP9X USP9Y	2.91e-05	2	188	2	12895410
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	2.91e-05	2	188	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	2.91e-05	2	188	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	2.91e-05	2	188	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	2.91e-05	2	188	2	6149581
Pubmed	The C allele of rs5743836 polymorphism in the human TLR9 promoter links IL-6 and TLR9 up-regulation and confers increased B-cell proliferation.	TLR9 IL6	2.91e-05	2	188	2	22132241
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	2.91e-05	2	188	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	2.91e-05	2	188	2	2387317
Pubmed	Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.	ARFGEF2 ARFGEF1	2.91e-05	2	188	2	10716990
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	2.91e-05	2	188	2	7365238
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	2.91e-05	2	188	2	17971360
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	2.91e-05	2	188	2	17971229
Pubmed	Association of polymorphisms in NR1I2 and ABCB1 genes with epilepsy treatment responses.	ABCB1 NR1I2	2.91e-05	2	188	2	17924830
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	2.91e-05	2	188	2	35898513
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	2.91e-05	2	188	2	28873507
Pubmed	Inhibition of IL-6 trans-signaling in the brain increases sociability in the BTBR mouse model of autism.	ITPR3 IL6	2.91e-05	2	188	2	27460706
Pubmed	IDI2, a second isopentenyl diphosphate isomerase in mammals.	IDI2 IDI1	2.91e-05	2	188	2	17202134
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	2.91e-05	2	188	2	3794341
Pubmed	Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.	C4A C4B	2.91e-05	2	188	2	22785613
Pubmed	Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.	C4A C4B	2.91e-05	2	188	2	32691186
Pubmed	Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.	ARFGEF2 ARFGEF1	2.91e-05	2	188	2	18417613
Pubmed	The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.	C4A C4B	2.91e-05	2	188	2	8390682
Pubmed	Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).	C4A C4B	2.91e-05	2	188	2	3902619
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	2.91e-05	2	188	2	7373044
Pubmed	Aberrant methylation of the netrin-1 receptor genes UNC5C and DCC detected in advanced colorectal cancer.	DCC UNC5C	2.91e-05	2	188	2	19242752
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	2.91e-05	2	188	2	1357031
Pubmed	Deletion of LRRTM1 and LRRTM2 in adult mice impairs basal AMPA receptor transmission and LTP in hippocampal CA1 pyramidal neurons.	LRRTM1 LRRTM2	2.91e-05	2	188	2	29784826
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	2.91e-05	2	188	2	16098595
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	2.91e-05	2	188	2	15787745
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	2.91e-05	2	188	2	30026462
Pubmed	Isopentenyl diphosphate isomerase, a cholesterol synthesizing enzyme, is localized in Lewy bodies.	IDI2 IDI1	2.91e-05	2	188	2	25950736
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	2.91e-05	2	188	2	6559257
Pubmed	Mulberroside A suppresses PXR-mediated transactivation and gene expression of P-gp in LS174T cells.	ABCB1 NR1I2	2.91e-05	2	188	2	27918128
Pubmed	Effects of NR1I2 and ABCB1 Genetic Polymorphisms on Everolimus Pharmacokinetics in Japanese Renal Transplant Patients.	ABCB1 NR1I2	2.91e-05	2	188	2	36233042
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	2.91e-05	2	188	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	2.91e-05	2	188	2	26800705
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	2.91e-05	2	188	2	1699796
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	2.91e-05	2	188	2	2997024
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	2.91e-05	2	188	2	3624865
Pubmed	Segmental copy-number gain within the region of isopentenyl diphosphate isomerase genes in sporadic amyotrophic lateral sclerosis.	IDI2 IDI1	2.91e-05	2	188	2	20955688
Pubmed	Usp9y (ubiquitin-specific protease 9 gene on the Y) is associated with a functional promoter and encodes an intact open reading frame homologous to Usp9x that is under selective constraint.	USP9X USP9Y	2.91e-05	2	188	2	12925892
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	2.91e-05	2	188	2	30041577
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	2.91e-05	2	188	2	3862104
Pubmed	Isopentenyl-diphosphate isomerases in human and mouse: evolutionary analysis of a mammalian gene duplication.	IDI2 IDI1	2.91e-05	2	188	2	14629038
Pubmed	Expression of pregnane-X-receptor transcript in peripheral blood mononuclear cells and correlation with MDR1 mRNA.	ABCB1 NR1I2	2.91e-05	2	188	2	15535420
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	2.91e-05	2	188	2	26814963
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	2.91e-05	2	188	2	8132550
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	2.91e-05	2	188	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	2.91e-05	2	188	2	26814708
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	2.91e-05	2	188	2	1438267
Pubmed	The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation.	DOCK11 DOCK10	2.91e-05	2	188	2	25729399
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	2.91e-05	2	188	2	19150565
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	2.91e-05	2	188	2	17506029
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	2.91e-05	2	188	2	23715124
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	2.91e-05	2	188	2	2993295
Pubmed	Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1.	SLC26A1 SLC26A6	2.91e-05	2	188	2	12217875
Pubmed	TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway.	TLR9 IRAK4	2.91e-05	2	188	2	17878374
Pubmed	Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.	C4A C4B	2.91e-05	2	188	2	33353966
Pubmed	Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes.	C4A C4B	2.91e-05	2	188	2	2900855
Pubmed	Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits.	LRRTM1 LRRTM2	2.91e-05	2	188	2	35662394
Pubmed	Genetic deficiency in complement component 4b does not alter radiation-induced lung disease in mice.	C4A C4B	2.91e-05	2	188	2	23259761
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	2.91e-05	2	188	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	2.91e-05	2	188	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	2.91e-05	2	188	2	15998580
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	2.91e-05	2	188	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	2.91e-05	2	188	2	2459207
Pubmed	Leucine-rich repeat transmembrane proteins are essential for maintenance of long-term potentiation.	LRRTM1 LRRTM2	2.91e-05	2	188	2	23931994
Pubmed	Regulation of endocytosis by CUP-5, the Caenorhabditis elegans mucolipin-1 homolog.	MCOLN1 MCOLN3	2.91e-05	2	188	2	11326278
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF449 ZXDC ZNF146 ZNF354A ZNF154 ZNF112 ZNF354B ZNF850 ZNF692 ZNF529 ZNF169 ZFPM2 ZNF594 ZNF526 ZNF616	1.43e-04	718	126	15	28
GeneFamily	Lipases\|Arylacetamide deacetylase family	AADAC PNLIPRP2 PNPLA3	4.62e-04	22	126	3	464
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	DOCK11 KIF1B DOCK10 SH2B2 SH2B1 APPL1 SNTB1	6.05e-04	206	126	7	682
GeneFamily	Glucagon receptor family	GCGR GLP2R	7.10e-04	6	126	2	269
GeneFamily	Transient receptor potential cation channels	MCOLN1 TRPM8 MCOLN3	9.53e-04	28	126	3	249
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	1.68e-03	9	126	2	1234
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN11A SCN8A	1.68e-03	9	126	2	1203
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000	ZNF449 NUP107 USP9X POT1 ARFGEF2 PHTF2 YTHDC2 HEATR1 TEX13B CUBN TEX11 FBXL5 RIF1 INTS6 AUNIP PLA2G4C ZDHHC23 PGAP1 CDK5RAP1 PARPBP TRMT5	5.55e-06	820	178	21	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_MedNas_2500	TEPSIN GCFC2 ZNF354A EPHA6 LRRN1 HSPH1 POT1 HMGCR CLSTN2 LRRTM3 HEATR1 STIL IDI1 DHX30 ABCB1 RIF1 ACSM3 AUNIP NRXN3 PSME4 PGAP1 SLIT1 LRRTM4 SCN8A PTCH2 PARPBP NIPBL SOWAHB MCOLN3	6.68e-06	1414	178	29	facebase_RNAseq_e10.5_Emin_MedNas_2500
CoexpressionAtlas	facebase_RNAseq_e10.5_Emin_MedNas_2500_K1	TEPSIN GCFC2 ZNF354A EPHA6 LRRN1 HSPH1 POT1 HMGCR CLSTN2 LRRTM3 HEATR1 STIL IDI1 DHX30 RIF1 AUNIP PSME4 PGAP1 LRRTM4 SCN8A PTCH2 PARPBP NIPBL SOWAHB	9.19e-06	1060	178	24	facebase_RNAseq_e10.5_Emin_MedNas_2500_K1
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_k-means-cluster#1_top-relative-expression-ranked_1000	NUP107 HSPH1 POT1 PHTF2 NCBP1 HEATR1 WDR3 RIF1 ZDHHC23 PGAP1 CDK5RAP1 TRMT5	2.57e-05	333	178	12	gudmap_dev gonad_e13.5_M_GermCell_Oct_k1_1000
CoexpressionAtlas	DevelopingKidney_e15.5_cortic collect duct_emap-28132_k-means-cluster#3_top-relative-expression-ranked_100	POT1 SCN8A TENM1 MCOLN3	7.21e-05	27	178	4	gudmap_developingKidney_e15.5_cortic collect duct_100_k3
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CUBN DCC NRXN3 PLA2G4C NALCN TRPM8 C4B HYDIN IL6	4.30e-08	169	187	9	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Mesenchymal\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CUBN DCC NRXN3 PLA2G4C TRPM8 C4B HYDIN IL6	7.21e-07	173	187	8	66f37c1437705734b20601656fa4aa1d92ca30be
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Mesenchymal-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CUBN DCC NRXN3 PLA2G4C TRPM8 C4B HYDIN IL6	7.21e-07	173	187	8	649b08a409095592cccf31883be69c754411280d
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DPY19L3 PNLIPRP2 GPR55 ZFPM2 FHAD1 SLIT1 PTCH2	8.57e-07	122	187	7	37612ad087d9c11d4a3466244ab36224de31930b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 CLSTN2 DCC ABCB1 MYO3A ACSM3 HYDIN UNC5D	1.40e-06	189	187	8	3b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EPHA6 CLSTN2 CUBN DCC ABCB1 MYO3A ACSM3 UNC5D	1.40e-06	189	187	8	28b502611829e4a24caff2562545c7db97686099
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHA6 DUOX2 USP9Y GLP2R TENM1 HYDIN UNC5D	5.67e-06	162	187	7	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MCM4 STIL FAM111B FANCA MYO3A AUNIP PARPBP	1.09e-05	179	187	7	88d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-4\|TCGA-Thryoid / Sample_Type by Project: Shred V9	ARFGEF1 MCM4 FAM111B ITPR3 SOWAHB MCOLN3 TMEM117	1.30e-05	184	187	7	d9659d1e4465fec68f48a22edef443f354f6c7cf
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LRRN1 DCC ZFPM2 ACSM3 NALCN UNC5C LRRTM4	1.35e-05	185	187	7	6712512100ccef456d2e2bd201d0987986c92ac9
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKRD13D OPN1SW ABCB1 PGAP1 C4A C4B	1.35e-05	123	187	6	a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPHA6 LRRTM1 DCC CACNG2 HECW2 LRRTM4 UNC5D	1.40e-05	186	187	7	bdc87e4631a8ea73e262e541aa84a28f24c94b00
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KANSL1L DOCK11 CLSTN2 DCC ABCB1 ACSM3 UNC5D	1.44e-05	187	187	7	9d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	DOCK10 ARFGEF2 MCM4 HMGCR HEATR1 ZNF169 ZDHHC23	1.66e-05	191	187	7	9454f642c3621370fa23640b631301346b300950
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 CLSTN2 DCC MYO3A ACSM3 HYDIN UNC5D	1.66e-05	191	187	7	1cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MYO1A C1orf87 DUOX2 IDI2 MYO3A NR1I2 NXF5	1.77e-05	193	187	7	315840bc48899f3a36d57b19197509de19716e3d
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP9X RPS6KA2 KIF1B ARFGEF1 HMGCR RIF1 SLC38A10	1.89e-05	195	187	7	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP9X RPS6KA2 KIF1B ARFGEF1 HMGCR RIF1 SLC38A10	1.89e-05	195	187	7	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	Enterocyte\|World / shred on cell type and cluster	AADAC MYO1A MAOB CUBN ABCB1 TMEM120A DHRS7	2.02e-05	197	187	7	1dd980fd066aef21694395a4b69df938501d9631
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-IPC_like\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	KLHL24 DCC ZFPM2 GSE1 PGAP1 SLIT1 TAC3	2.09e-05	198	187	7	6d12ecaa9532c134d9c4562534dcb59a6420b4d3
ToppCell	C_01\|World / shred on cell type and cluster	AADAC MYO1A MAOB CUBN ABCB1 TMEM120A DHRS7	2.09e-05	198	187	7	71d38084d09a96331877384ce6346f0de4bdcef9
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-IPC_like-IPs_and_early_cortical_neurons\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	KLHL24 DCC ZFPM2 GSE1 PGAP1 SLIT1 TAC3	2.09e-05	198	187	7	7943e4f67c3d6efb5c8b00aa0ff3cfe7be10c48d
ToppCell	LPS_only-Epithelial_airway-airway_epithelial-Ciliated\|LPS_only / Treatment groups by lineage, cell group, cell type	KIF6 C1orf87 SAMD15 FHAD1 OSCP1 HYDIN IQCE	2.09e-05	198	187	7	6d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-Dividing_AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MCM4 STIL FAM111B FANCA MYO3A ANKRD34B PARPBP	2.23e-05	200	187	7	af3dc76b4507bf4edd265169f5dfbbb8a19eb394
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZFPM2 SPINK13 NRXN3 LRRTM4 LRRTM2 OTUD7A	2.81e-05	140	187	6	7ca49bd7ba9381e75c10f888775df17e5d46804d
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZFPM2 SPINK13 NRXN3 LRRTM4 LRRTM2 OTUD7A	2.81e-05	140	187	6	1a31bc33d5723b9bc528cc0047ca5f4c80531c7a
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	EPHA6 DCC SLC35F4 CACNG2 MYO3A LRRTM4	3.84e-05	148	187	6	d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_B\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	MAOB NCBP1 YTHDC2 ZNF169 IL6 IQCE	4.14e-05	150	187	6	98fdc6bdfde84d680e11d8727502b79afbf64303
ToppCell	facs-Liver-Hepatocytes\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AADAC GCGR SLC25A25 SLC26A1 ACSM3 C4B	5.16e-05	156	187	6	e2cda3ad4e5f44a80133864c5a38b766afb952ce
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	HCN3 CACNG2 NRXN3 ANKRD34B UNC5D BAIAP2L2	6.14e-05	161	187	6	b81b346309f3facbfbebd91cae4c5b33c7bd24ef
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_neural-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CLSTN2 DCC ZFPM2 SHD GSE1 TAC3	6.14e-05	161	187	6	bd520c9a1927d5d5355b4421e6b90b58bfb76a42
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LRRN1 STIL FAM111B FANCA MYO3A PARPBP	7.52e-05	167	187	6	50c29ea660bf07b890e4ac1a1985d0761d863dee
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHA6 GCGR CLSTN2 SLC35F4 ADRA1D SLIT1	7.52e-05	167	187	6	3dfec2fcc36caa6e394efae5e540a6fa28759977
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHA6 GCGR CLSTN2 SLC35F4 ADRA1D SLIT1	7.52e-05	167	187	6	95b3b5ba3414729f0460a26a0deca48de0cbe33e
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHA6 GCGR CLSTN2 SLC35F4 ADRA1D SLIT1	7.52e-05	167	187	6	9480739587d51e67a281778b9bddd7b5ffc3ad92
ToppCell	343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	MCM4 STIL FAM111B MYO3A TRPM8 PARPBP	8.03e-05	169	187	6	a949f547b53126a208819bade74a1ac9b2a36ea7
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-TRGV2_gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF449 DOCK10 GPR55 ZNF529 FAT2 PCNX1	8.03e-05	169	187	6	8caf7996796a2e2716e3855de855c903d6126bf2
ToppCell	343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|343B / Donor, Lineage, Cell class and subclass (all cells)	MCM4 STIL FAM111B MYO3A TRPM8 PARPBP	8.03e-05	169	187	6	195d5cd60d646ac6d40a3321b2f739917e7aef14
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	LRRN1 MCM4 STIL FAM111B AUNIP PARPBP	9.14e-05	173	187	6	20889aa85e36ad3bafdb91b91e43964493c949f9
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	LRRN1 MCM4 STIL FAM111B AUNIP PARPBP	9.14e-05	173	187	6	46e601b7938b1dd0aa3df7aa056c4bd07b1620c1
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	STIL SH2B1 PGM5 DHX30 AUNIP PARPBP	9.43e-05	174	187	6	6c36d607c48267a75ab4da6fb2fe3f931d1b3b52
ToppCell	CV-Severe-7\|CV / Virus stimulation, Condition and Cluster	HMGCR HEATR1 ZNF169 TMEM168 ZDHHC23 CDK5RAP1	1.00e-04	176	187	6	3de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_2\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	SHD MYO3A NRXN3 GSE1 DHRS7 TAC3	1.10e-04	179	187	6	d95367d689732ab2653e8d70d8d8e5eb15ae6eef
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 CUBN DCC MYO3A ANKRD34B UNC5D	1.10e-04	179	187	6	58ae5a97fe2a14e1c6fdeb886397eb06fdaf0428
ToppCell	facs-Lung-EPCAM-24m-Myeloid-Dendritic_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRUB1 ZNF692 INTS6 UNC5C PTCH2 TMEM117	1.14e-04	180	187	6	5b7d2336ed09d07f6b8dd91c1fa9c5ade633c104
ToppCell	facs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TRUB1 ZNF692 INTS6 UNC5C PTCH2 TMEM117	1.14e-04	180	187	6	d33bb00f2b7d07dda9015cb8eafd742c2b2e9ace
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 ABCB1 SLC35F4 HYDIN UNC5D SNTB1	1.21e-04	182	187	6	5e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EPHA6 DOCK11 GCGR SLC35F4 ANKRD34B TENM1	1.24e-04	183	187	6	121791ef84e7ce377ed6f5b7953af8865e04958e
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LRRN1 DOCK10 DCC ZFPM2 NALCN LRRTM4	1.24e-04	183	187	6	7eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKD1L2 DCC TEX11 TENM1 HYDIN UNC5D	1.28e-04	184	187	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GPRASP1 DOCK10 PGAP1 TENM1 PCNX1 SORL1	1.28e-04	184	187	6	bd786db4dc4edae6d5cfc0b69901983dea19f729
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKD1L2 DCC TEX11 TENM1 HYDIN UNC5D	1.28e-04	184	187	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKD1L2 DCC TEX11 TENM1 HYDIN UNC5D	1.28e-04	184	187	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MCM4 ZFPM2 FAM111B MYO3A TRPM8 PARPBP	1.28e-04	184	187	6	6b2449ac65a2322aa0479fba0d89828f243aabbe
ToppCell	343B-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MCM4 ZFPM2 FAM111B MYO3A TRPM8 PARPBP	1.28e-04	184	187	6	e90622b82fa7f16a1faaf7a4724c958f2d83341d
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DOCK11 PRND SLC35F4 ANKRD34B TENM1 UNC5D	1.28e-04	184	187	6	7d41784eac0935e77d6bc701f20c693adf998730
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-matrix_-_immature_1\|E16.5-samps / Age Group, Lineage, Cell class and subclass	ZNF354A IDI2 ACSM3 LRP10 PCNX1	1.30e-04	116	187	5	f32f7eddfe33adb3b5cf7c34667a481a305c5163
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LRRN1 DOCK10 DCC ZFPM2 NALCN LRRTM4	1.32e-04	185	187	6	3b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 CUBN DCC MYO3A HYDIN UNC5D	1.36e-04	186	187	6	f28d72b47624b69a580b4429e2be560a26898591
ToppCell	ILEUM-inflamed-(8)_Fibroblast-(8)_Smooth_muscle_cells\|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	LAMB4 DUOX2 GLP2R TAC3 HYDIN SNTB1	1.36e-04	186	187	6	cacc2f0b2ed46516173b61ba1c5c226a2db7cddc
ToppCell	5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LRRTM1 BCAR1 ADRA1D UNC5C LRRTM4 UNC5D	1.40e-04	187	187	6	8ee3bf885897efd634c3a0567637142a9f55e693
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	USP9X HSPH1 DOCK10 ARFGEF1 PCNX1 NIPBL	1.44e-04	188	187	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MAOB DCC ZFPM2 PGM5 ACSM3 NALCN	1.44e-04	188	187	6	293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EPHA6 DOCK11 HHATL SLC35F4 ANKRD34B TENM1	1.44e-04	188	187	6	8de5a07301f9b5984680c873e5a92395b5ed3dd3
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MAN2B1 TEX11 ZNF354B INTS6 ACSM3 PTCH2	1.48e-04	189	187	6	b13f315f617840eb5143a4e8a33a657c20365c21
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lhx6\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DOCK11 ANKRD34B UNC5C UNC5D BAIAP2L2	1.52e-04	120	187	5	a4e3f9a83bc52ccc75bcd64b1be4e2c5441f6d1a
ToppCell	Globus_pallidus-Neuronal\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	GPRASP1 EPHA6 CACNG2 NRXN3 SCN8A TENM1	1.52e-04	190	187	6	416de85d8841dac883faa6f5339b2fb461a09e82
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	KLHL24 HSPH1 ARFGEF2 IDI1 ZDHHC23 PGAP1	1.57e-04	191	187	6	1ecd9849d14d5ebf3daf610e83fb50820cafd3ed
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRN1 MAOB USP9X RPS6KA2 HMGCR MCOLN3	1.61e-04	192	187	6	5b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	EPHA6 FAM111B ITPR3 MYO3A NRXN3 SORL1	1.61e-04	192	187	6	d3634574b2e8d2ded6446969361b70761b331aea
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRN1 MAOB GCGR IDI1 HHATL PGAP1	1.61e-04	192	187	6	6fb56d062c35617b18b927704bf5fba894faed81
ToppCell	severe-Myeloid-Neutrophils_3\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	ZNF354A ANKRD34B LRP10 DHRS7 PCNX1 SORL1	1.66e-04	193	187	6	f4d43dfbf4115dd0f843ea5cf08049220342a047
ToppCell	droplet-Kidney-nan-18m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRN1 MAOB GCGR IDI1 HHATL PGAP1	1.66e-04	193	187	6	fa8bcf2a5ab7b08fae98a1466a936995142b4309
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-J_(AT1-AT2_progenitors)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	MCM4 STIL FAM111B MYO3A TRPM8 PARPBP	1.71e-04	194	187	6	4d6ae2b25db11a4ae6dadee83be5c8c05b1225c3
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DOCK11 RPS6KA2 DOCK10 SLC35F4 TENM1 TAC3	1.71e-04	194	187	6	02a9cc821c2b14aa7d0e55661a5fab66364474e1
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GPRASP1 DOCK10 PGAP1 TENM1 PCNX1 SORL1	1.71e-04	194	187	6	a44be2f021cfdd0fcdc698c3f04d66db7a1aa6c2
ToppCell	proximal-Hematologic-Natural_Killer_T-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DOCK10 TEP1 ABCB1 FANCA AREL1 ZNF594	1.76e-04	195	187	6	4d7c2c4d0130c2d46877ff6dd4584525d8f74daf
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MCM4 STIL FAM111B FANCA AUNIP PARPBP	1.76e-04	195	187	6	75759fd7f925725f0ecd07214afcca5aa2158f9e
ToppCell	proximal-3-Hematologic-Natural_Killer_T\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DOCK10 TEP1 ABCB1 FANCA AREL1 ZNF594	1.76e-04	195	187	6	93093545bb23d2619ace029a52cffa1f673a0c2a
ToppCell	proximal-Hematologic-Natural_Killer_T\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	DOCK10 TEP1 ABCB1 FANCA AREL1 ZNF594	1.76e-04	195	187	6	3944e4800f5d904d4efa401ce8913ec0e0781211
ToppCell	Bronchial-NucSeq-Stromal-Schwann-Schwann_Myelinating\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LARP6 EPHA6 CUBN SLIT1 LRRTM4 OSCP1	1.80e-04	196	187	6	efeb272bc9e37e60d15d056b7574991c5c7501bc
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DOCK11 RPS6KA2 DOCK10 SLC35F4 TENM1 TAC3	1.80e-04	196	187	6	7af6c5147ac859353504d19727dbe24f63a29dd4
ToppCell	PSB-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	C1orf87 CASC2 SAMD15 FHAD1 OSCP1 HYDIN	1.85e-04	197	187	6	6865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell	MS-cycling-\|MS / Condition, Cell_class and T cell subcluster	MCM4 STIL SH2B2 FAM111B AUNIP NT5DC2	1.91e-04	198	187	6	19c5d6b65de490118574b1f86b45c58b3a51df7f
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-CD8+_T_naive\|Int-URO / Disease, condition lineage and cell class	GPR55 MCM4 ABCB1 FAM111B OTUD7A ZNF616	1.91e-04	198	187	6	8c7d00d8c27fb47954d8ac53eebc4582e92b970c
ToppCell	LPS_only-Epithelial_airway-airway_epithelial\|LPS_only / Treatment groups by lineage, cell group, cell type	CAPN9 C1orf87 DUOX2 GCGR SAMD15 HYDIN	1.91e-04	198	187	6	e035380578c01b0243bfef29ca9b50cc17cce771
ToppCell	LPS_only-Epithelial_airway\|LPS_only / Treatment groups by lineage, cell group, cell type	CAPN9 C1orf87 DUOX2 GCGR SAMD15 HYDIN	1.91e-04	198	187	6	ba090210392e001a3f7bdf09371b3f0e0c8c7ef3
ToppCell	distal-1-mesenchymal-Alveolar_Fibroblast\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	MAOB CLSTN2 PKD1L2 PGAP1 IL6 MCOLN3	1.91e-04	198	187	6	6594c35ab203dc51462167c61807b0d49fa30fb2
ToppCell	MS-cycling\|MS / Condition, Cell_class and T cell subcluster	MCM4 STIL SH2B2 FAM111B AUNIP NT5DC2	1.91e-04	198	187	6	0c22f2cc0e5ca91cabcd4aac2b9ef05af47e967f
ToppCell	COVID-19_Mild-T/NK_proliferative\|COVID-19_Mild / Disease condition and Cell class	MCM4 STIL FAM111B FANCA NT5DC2 PARPBP	1.96e-04	199	187	6	9f9a88d2b099646c1e1a7ee3f8d39cb1a2498ad7
ToppCell	Macroglial-Oligodendrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	KIF6 LARP6 DOCK10 NRXN3 HECW2 UNC5C	2.01e-04	200	187	6	4dbac2f2587e87ca5a0622f50439bb5447e93c7f
ToppCell	Sepsis-URO-Lymphocyte-T/NK-dn_T\|URO / Disease, condition lineage and cell class	RBM26 ZNF526 GSE1 PARPBP TRMT5 KLHDC4	2.01e-04	200	187	6	04ea6381b93a5d8bbeda4d71c788d7fbac6d40bc
ToppCell	LPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	KIF6 C1orf87 DUOX2 SAMD15 FHAD1 HYDIN	2.01e-04	200	187	6	96701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCell	Neuronal-Inhibitory\|Neuronal / cells hierarchy compared to all cells using T-Statistic	DOCK11 RPS6KA2 DOCK10 SLC35F4 TENM1 TAC3	2.01e-04	200	187	6	9ff8647e2de0b538e15929dca88ebb20ff7ab043
ToppCell	Macroglial-Oligodendrocytes-OPALIN--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	KIF6 LARP6 DOCK10 NRXN3 HECW2 UNC5C	2.01e-04	200	187	6	26b989e30bbbaf30904ced03f6aae3dea25c732c
ToppCell	LPS_IL1RA-Epithelial_airway-airway_epithelial-Ciliated\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	C1orf87 DUOX2 SAMD15 FHAD1 OSCP1 HYDIN	2.01e-04	200	187	6	4992dbf0514d674017315dbd20d91dfec0c608e9
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LRRN1 HMGCR LRRTM3 IDI1 SLIT1 LRRTM2	2.01e-04	200	187	6	ad777683adeb2ce45ade570386235e311fa7ea2d
ToppCell	Macroglial-Oligodendrocytes-OPALIN---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	KIF6 LARP6 DOCK10 NRXN3 HECW2 UNC5C	2.01e-04	200	187	6	1314664c1721e9ecb1e2c3482a039044b0fe50a9
ToppCell	Macroglial-Oligodendrocytes-OPALIN-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	KIF6 LARP6 DOCK10 NRXN3 HECW2 UNC5C	2.01e-04	200	187	6	8b229f095fc113aecfc94b64862a9e0fdcc363ce
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Neuron\|10w / Sample Type, Dataset, Time_group, and Cell type.	LRRN1 DOCK10 DCC NRXN3 GSE1 TAC3	2.01e-04	200	187	6	332905a686356cd1e024d40679be98e9d8b1b5e8
Drug	PAN copolymer	MCOLN1 SHD ACSM3 C4A TAC3 IL6	8.10e-07	40	185	6	CID000161656
Disease	mucolipidosis type IV (implicated_via_orthology)	MCOLN1 MCOLN3	1.08e-04	3	178	2	DOID:0080490 (implicated_via_orthology)
Disease	hepatocellular carcinoma (is_implicated_in)	KIF1B POT1 TLR9 TEP1 ABCB1 PNPLA3 IL6	1.20e-04	181	178	7	DOID:684 (is_implicated_in)
Disease	TYPE 1 DIABETES MELLITUS	ITPR3 IL6	2.15e-04	4	178	2	222100
Disease	levulinate 4-oxovalerate measurement	IDI2 ADRA1D	2.15e-04	4	178	2	EFO_0021024
Disease	Diabetes mellitus type 1	ITPR3 IL6	2.15e-04	4	178	2	cv:C0011854
Disease	glycoproteinosis (implicated_via_orthology)	MCOLN1 MCOLN3	2.15e-04	4	178	2	DOID:3343 (implicated_via_orthology)
Disease	epilepsy (biomarker_via_orthology)	ABCB1 NR1I2 IL6	2.65e-04	21	178	3	DOID:1826 (biomarker_via_orthology)
Disease	Anemia, Megaloblastic	MAOB CUBN	3.58e-04	5	178	2	C0002888
Disease	Oxalosis	SLC26A1 IL6	3.58e-04	5	178	2	C1298681
Disease	type 2 diabetes mellitus (is_implicated_in)	KIF6 GCGR HMGCR ABCB1 PNPLA3 IL6	6.19e-04	171	178	6	DOID:9352 (is_implicated_in)
Disease	X-23641 measurement	KANSL1L PNPLA3	7.45e-04	7	178	2	EFO_0800854
Disease	Lupus Erythematosus, Systemic	IRAK4 C4A C4B IL6	9.08e-04	71	178	4	C0024141
Disease	stomach cancer (is_implicated_in)	CAPN9 TEP1 GSE1 IL6	9.57e-04	72	178	4	DOID:10534 (is_implicated_in)
Disease	Hyperoxaluria	SLC26A1 IL6	9.89e-04	8	178	2	C0020500
Disease	primary ovarian insufficiency (is_implicated_in)	BBS9 FANCA	9.89e-04	8	178	2	DOID:5426 (is_implicated_in)
Disease	advanced glycation end-product measurement	MMP27 FANCA	1.27e-03	9	178	2	EFO_0007819
Disease	gallbladder neoplasm	DCC ABCB1	1.27e-03	9	178	2	EFO_0004606
Disease	underweight body mass index status	DCC NRXN3	1.27e-03	9	178	2	EFO_0005936
Disease	Hodgkins lymphoma	CLSTN2 OPN1SW ZNF526 ACSM3	1.55e-03	82	178	4	EFO_0000183
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN11A SCN8A	1.58e-03	10	178	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN11A SCN8A	1.58e-03	10	178	2	DOID:0080422 (implicated_via_orthology)
Disease	Graves' disease (is_implicated_in)	C4A C4B IL6	1.68e-03	39	178	3	DOID:12361 (is_implicated_in)
Disease	liver fibrosis measurement	HMGCR ZFPM2 ITPR3 PNPLA3	1.85e-03	86	178	4	EFO_0010576
Disease	Autoimmune Diseases	HMGCR C4B IL6	2.08e-03	42	178	3	C0004364
Disease	Malignant neoplasm of breast	RAF1 KIF6 C1orf87 ARFGEF2 BCAR1 CUBN MCOLN1 ABCB1 RIF1 TENM1 APPL1 FASTKD3 NIPBL IL6 SORL1	2.27e-03	1074	178	15	C0006142
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN11A SCN8A	2.30e-03	12	178	2	DOID:0060170 (implicated_via_orthology)
Disease	intracranial aneurysm (is_implicated_in)	PKD1 IL6	2.30e-03	12	178	2	DOID:10941 (is_implicated_in)
Disease	disks large homolog 3 measurement	TEX11 ZFPM2	2.30e-03	12	178	2	EFO_0802472
Disease	esophagus squamous cell carcinoma (is_implicated_in)	DCC FANCA MBD4	2.54e-03	45	178	3	DOID:3748 (is_implicated_in)
Disease	coronary artery disease (is_implicated_in)	KIF6 HMGCR CUBN PNPLA3	3.20e-03	100	178	4	DOID:3393 (is_implicated_in)
Disease	cholestasis (biomarker_via_orthology)	MAOB ABCB1 NR1I2	3.24e-03	49	178	3	DOID:13580 (biomarker_via_orthology)
Disease	memory performance	KIF1B CLSTN2 HEATR1 BBS9 ZNF354B NT5DC2 LRRTM4 SORL1	3.52e-03	409	178	8	EFO_0004874
Disease	response to trauma exposure	PHTF2 BBS9 UNC5D	3.63e-03	51	178	3	EFO_0008483
Disease	isocitrate measurement	LRRTM4 TRPM8	4.11e-03	16	178	2	EFO_0010505
Disease	Pheochromocytoma, Extra-Adrenal	MAOB KIF1B	4.11e-03	16	178	2	C1257877
Disease	Charcot-Marie-Tooth disease type 2	AARS1 KIF1B	4.64e-03	17	178	2	cv:C0270914
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR9 IL6	4.64e-03	17	178	2	DOID:8677 (biomarker_via_orthology)
Disease	non-alcoholic fatty liver disease (is_implicated_in)	PNPLA3 IL6	5.20e-03	18	178	2	DOID:0080208 (is_implicated_in)
Disease	Pheochromocytoma	MAOB KIF1B	5.78e-03	19	178	2	C0031511
Disease	cancer (implicated_via_orthology)	RAF1 IDI2 IDI1 GUK1 RFT1 NIPBL	5.88e-03	268	178	6	DOID:162 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ISNAHFAKLRDFITL	ANKRD13D	386	Q6ZTN6
NLLFSSRRGHLFLQT	C4B	131	P0C0L5
FSFLGLKISHRLINQ	AADAC	376	P22760
FLHGNASLLFRRTKA	BCAR1	596	P56945
SHILQKDAFLVFRSL	ARFGEF1	416	Q9Y6D6
FLTIFNLTHISAEKR	GSE1	866	Q14687
FSHVLQKDAFLVFRS	ARFGEF2	366	Q9Y6D5
NLIHTILFGFLALST	DPY19L3	466	Q6ZPD9
SLRFIHGLIKQFSEN	DHX30	971	Q7L2E3
FAQFFHGSLASLTIR	CLSTN2	511	Q9H4D0
SKHALRGFFNGLRTE	DHRS7	206	Q9Y394
GFLLQSQLSRLFLKH	C1orf87	211	Q8N0U7
LTTHNFARKTFLKLA	RAF1	136	P04049
ISKLNEHFSRFGTLV	RBM26	546	Q5T8P6
AFLTETKLIHFLRTQ	RFT1	516	Q96AA3
FTLLKHVQGSLQTRL	INTS6	831	Q9UL03
TLTHVAFSGIFNKRD	SPINK13	16	Q1W4C9
AAFRGHLTRTKLLAS	IQCE	551	Q6IPM2
THLILFFRTLGLQTK	NUP107	551	P57740
LRTHVKGLSNFINFI	PARPBP	246	Q9NWS1
VSGALQLLFKHFSQR	ITPR3	1071	Q14573
FSVLITFDNKAHSGR	MCOLN1	256	Q9GZU1
SLRKAHIFGITFSFT	ABCB1	931	P08183
LNLLRTIFDFHAIKG	PGM5	201	Q15124
TNGLALSKRFITRHQ	ANKRD34B	281	A5PLL1
IFSATALGFLAHKRG	MAOB	501	P27338
RHNIILSAGIFFVSA	CACNG2	131	Q9Y698
SGNLHSRKLVSFTLS	HECW2	176	Q9P2P5
LLQLFGGTRKDFSHT	MCM4	481	P33991
SLFIFGIVHLLKNTS	MMP27	496	Q9H306
SLFSAHLQVTGFQIK	DCC	21	P43146
VLANHLLGSKFISFG	OR1A2	81	Q9Y585
IQRFAFSATGLLSHV	KANSL1L	321	A0AUZ9
QLTKINFAHFLRLSS	LRRTM2	216	O43300
SFRNVIIFALSGHVL	HHATL	71	Q9HCP6
LLRSLTHFSNGKAVT	LRP10	261	Q7Z4F1
SFHKIIAGSVALFLS	LRRTM4	421	Q86VH4
VFVQTLLHLAAKSFS	NCBP1	546	Q09161
AAFGVDSLLLKSSRH	MGAM2	646	Q2M2H8
FTLTITFDNKAHSGR	MCOLN3	241	Q8TDD5
ARNSFAGLFKLTELH	LRRTM1	201	Q86UE6
STFLAKLNQLFSKHG	MYO1A	466	Q9UBC5
SRFARLQKLHTSIAG	HMGCR	626	P04035
EIGNHLKLGSAFTFR	KIF1B	1106	O60333
THQENKRLFGFVLRT	APPL1	576	Q9UKG1
LFSSHLATLQGLKVF	ZFPM2	931	Q8WW38
SRNHAAPFSKVLTFL	HSPH1	421	Q92598
HLLLSNTFLQFFGRA	BAIAP2L2	191	Q6UXY1
HFQKVLNRSLFTGLR	DUOX2	1471	Q9NRD8
GLHALFKGDFRISSI	PCNX1	1821	Q96RV3
LTQFTKTILHFIGLQ	FAT2	676	Q9NYQ8
FTGSETLKHLVLQFL	NXF5	271	Q9H1B4
FLSSLIQASSIFRLH	OR5A1	156	Q8NGJ0
IGIFHPSFNLSKFLR	PNPLA3	81	Q9NST1
IHANLFASFVLKASS	GCGR	176	P47871
SLLGRLLVHQFSNKS	NIPBL	1586	Q6KC79
HSVFFTLKVSILLGS	NRXN3	6	Q9Y4C0
AQDFSILGKRSSLLH	KIF6	531	Q6ZMV9
HLLKLFGTFGVISSV	LARP6	216	Q9BRS8
SHGSSFFLLILKRNS	TEPSIN	81	Q96N21
GERKFIFAGLLLTSH	OTUD7A	631	Q8TE49
FSHFKNFRLPGVLSS	NR1I2	166	O75469
TVNKFSLRVFGSHKA	HCN3	56	Q9P1Z3
FFLRHLAIINLGNST	OR8J3	61	Q8NGG0
LLNLLAIHGFSTFLK	GPR55	36	Q9Y2T6
FQSFTRLKSATHLVI	BBS9	721	Q3SYG4
LGTFFTHAALQSLRL	PKD1L2	2161	Q7Z442
FNATSFLRHIRKLGQ	PNCK	301	Q6P2M8
ANAKSIGHLIFARLL	PLA2G4C	271	Q9UP65
RTGQLIAVHFTNFSL	CUBN	1081	O60494
EKGLLHRAFSVVLFN	IDI2	46	Q9BXS1
FFVLNKSTTIGRHEN	FHAD1	11	B1AJZ9
LNKSHLNFSSLLIGR	HYDIN	4086	Q4G0P3
EKGLLHRAFSVFLFN	IDI1	46	Q13907
IRLFIQLTLSSFHGF	GLP2R	416	O95838
IQRFADTHSLKTLFT	KLHL24	171	Q6TFL4
LKRLLQEHSGIFGFS	GUK1	21	Q16774
SATALKHVFASLRLF	DOCK10	1531	Q96BY6
VSLKHVFASLRAFIS	DOCK11	1451	Q5JSL3
FIQFLLQSAHKLSRS	GCFC2	726	P16383
KHFGSALRLRQTFHL	CASC2	56	Q6XLA1
LKRFFSHTLTQILTH	FANCA	316	O15360
LAATFIRSLHKNIGG	AREL1	421	O15033
SRGLSNFTSTHLLLK	MBD4	201	O95243
LSNALARLRGFKDHF	MAN2B1	476	O00754
RTTILFLKLALFSAH	LYPD1	126	Q8N2G4
KRQLILFGGFHESTR	KLHDC4	186	Q8TBB5
EALFRFSHLILTFKT	LAMB4	121	A4D0S4
TSKQLRHFKFLSVSF	HEATR1	1506	Q9H583
FHIRRFEALLQTGKS	IRAK4	51	Q9NWZ3
RALGILTSHQSGFLK	FBXL5	406	Q9UKA1
NASGKLVALHTFGLF	FAM111B	656	Q6SJ93
LRTALKAAGFQLSSH	CAPN9	616	O14815
FITNFISGRKLIHVN	SAMD15	566	Q9P1V8
FVIVLSSLKHGLFSG	SLC38A10	166	Q9HBR0
IGLTRKSNSALHFFI	NEURL4	436	Q96JN8
HQRSIASFFTLQPGK	AUNIP	61	Q9H7T9
NLLFSSRRGHLFLQT	C4A	131	P0C0L4
THLILRSFKEFLQSS	IL6	191	P05231
SNFQLDRKTRFIIHG	PNLIPRP2	81	P54317
STISAHAFAGLKNLL	LRRN1	156	Q6UXK5
HFQILLAAGSAVTFR	PKD1	1906	P98161
GKAFSQFSTLALHLR	ZNF146	246	Q15072
SFLRKHDGHFTVIQL	EPHA6	761	Q9UF33
KLASQHSGFSQLVIF	OR10K1	186	Q8NGX5
GNFRFSSKHALTVVL	OPN1SW	141	P03999
LSALNSHKDRFISGR	PHF1	306	O43189
FLSLLATGNAKTRFH	GPRASP1	1281	Q5JY77
TQAHTRALKSLISFL	TAS2R41	226	P59536
LSSFTTILFFIGNHR	TAS2R60	151	P59551
QLAARFLFTTGFHTK	USP9X	2046	Q93008
LTFNFQGKAKHLRLS	SH2B1	566	Q9NRF2
RLLFAKLFGHLTSAR	PHTF2	581	Q8N3S3
LHSKASNLLLGFDRS	SORL1	211	Q92673
FIIHSFLSAKITRLG	SNTB1	521	Q13884
GFSGRFLKLESHSIT	TRMT5	11	Q32P41
LSLRSSQGFLHLKFA	SHD	276	Q96IW2
KRVFLIDLNSTHGTF	PPP1R8	81	Q12972
LLFLGNFFTTLRVVH	TMEM120A	316	Q9BXJ8
FARVHGVSQLIKAFL	LCMT1	71	Q9UIC8
SFHKIIAGSVALFLS	LRRTM3	416	Q86VH5
FVKLLGRTLHRSGSF	RIF1	256	Q5UIP0
FAIAISLGKIFALRH	SLC26A6	356	Q9BXS9
SALFRKLENVLFTHF	FASTKD3	426	Q14CZ7
LFDLHQRFSSLKAVL	PTCH2	756	Q9Y6C5
GSFLRIYSLHTKLQS	POT1	236	Q9NUX5
RVASKSSLGQHLQFF	TENM1	2256	Q9UKZ4
HLFSFGLSSRKVVLN	PGAP1	471	Q75T13
LSTQRGSLHVFLTKL	WDR19	336	Q8NEZ3
VLLVTFNHLDTIKGF	OSCP1	121	Q8WVF1
LDLFHKLTSGRQLAA	SLC35F4	6	A4IF30
VTNAALLSHFKSFLR	SOWAHB	21	A6NEL2
GHTFRSSLSVRLLKF	ADRA1D	326	P25100
FQRLAIFGSVRALHK	ACSM3	16	Q53FZ2
SSRLAAGPTFQHFLK	CDK5RAP1	56	Q96SZ6
SLFKHILRTEGAFGL	SLC25A25	421	Q6KCM7
FRFQLLTSKETLHLF	STIL	326	Q15468
ATFTATKQLQRHLGF	TGFBRAP1	61	Q8WUH2
FGRLFSLSKHQRIHS	ZNF616	726	Q08AN1
KTFITVSALFSHNRA	ZXDC	306	Q2QGD7
GLLSKFLTNLHVVAA	TEP1	1556	Q99973
HEKLNASRGFFATLV	AARS1	336	P49588
RHNFTLAFSTAEKLA	SMTNL1	436	A8MU46
KGSALTFSVAFQALR	TRAPPC14	446	Q8WVR3
VATLVSHFGQLHKRF	SLC26A1	301	Q9H2B4
QKRVSFAHLSLAPSF	TLR9	346	Q9NR96
LLFSHLSAVQTRGIK	PRND	16	Q9UKY0
LGFSSLLHFKTKSRS	ZBED8	546	Q8IZ13
LSRHNSKSSIFSFRG	SCN8A	556	Q9UQD0
GLALRFLNHLTSFKE	TEX11	891	Q8IYF3
LTFNFQGKAKHLRLS	SH2B2	456	O14492
GRFTVFLNKSAKHLS	TRAV29DV5	86	P04437
TFFILSAFKLRDTHL	TMEM168	276	Q9H0V1
IQLAARFLFTTGFHT	USP9Y	2046	O00507
FAVLSRLVAHGKQLF	NT5DC2	251	Q9H857
RLVAHGKQLFLITNS	NT5DC2	256	Q9H857
LHFKGNTFSLQISVL	UNC5D	741	Q6UXZ4
VQKHLAGLFNSITSF	PSME4	326	Q14997
QTARLFLSHFGFLSL	RALGAPB	1106	Q86X10
THRRKEQTLFFLSLG	ZDHHC23	131	Q8IYP9
KAFSHSLDLNSIFRV	ZNF112	366	Q9UJU3
AFIHRLSQSLGLVSK	YTHDC2	76	Q9H6S0
GKTFASLANLSRHQL	ZNF526	506	Q8TF50
TFSGRTAFLKHQRLH	ZNF594	331	Q96JF6
LATKLLSLSGVFAVH	TRUB1	61	Q8WWH5
KHALFIFGPFNSIRS	SCN11A	106	Q9UI33
KHISANHTLGFILFS	VN1R17P	126	Q8TDU5
ILTGLIAGKFLFHQR	TMEM117	76	Q9H0C3
KSFSQRSALLQHRGV	ZNF154	336	Q13106
RNFHFLSKLVLSAGP	TECRL	31	Q5HYJ1
SFSRRSGLFIHQKIH	ZNF354A	306	O60765
GKFFRLTSALIQHQR	ZNF529	456	Q6P280
AGIVFRLHSSNKSSL	TRPM8	811	Q7Z2W7
LFFLLRIHFGQITSN	WDR3	856	Q9UNX4
SFSRRSGLFIHQKIH	ZNF354B	306	Q96LW1
AKGTFTSLRAIQTLH	SLIT1	421	O75093
LLQRLFKSHSSLEGL	TAC3	46	Q9UHF0
ALHFKGSTHNLRLSI	UNC5C	731	O95185
GKSFTFHSALIRHQR	ZNF850	371	A8MQ14
KSFASGSALLQHQRI	ZNF850	456	A8MQ14
FGFKSALIRHQRTHS	ZNF169	551	Q14929
GKSFSRLTALTLHQR	ZNF449	441	Q6P9G9
FAKLHRSAALVLASN	TEX13B	96	Q9BXU2
GFSLHSQLAKFLLDR	ZNF692	46	Q9BU19
RVRHSFLSNAFFLKV	SIGLEC16	126	A6NMB1
SVRSKFHVLFLLFVA	ZDHHC15	206	Q96MV8
NLGTHKFLAQILTAF	GEMIN4	571	P57678
HLFRGFSFVASSLIQ	RPS6KA2	371	Q15349
ALSKFTFRGLKSLTH	LGI3	126	Q8N145
TFRGLKSLTHLSLAN	LGI3	131	Q8N145
NFSSAGKAITVLFRI	NALCN	1371	Q8IZF0
LGFSHRILFANFIKR	MYO3A	986	Q8NEV4