Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	SCF complex assembly	CAND1 CAND2	2.37e-05	2	101	2	GO:0010265
Domain	TATA-bd_TIP120	CAND1 CAND2	2.84e-05	2	100	2	IPR013932
Domain	TIP120	CAND1 CAND2	2.84e-05	2	100	2	PF08623
Domain	ARM-type_fold	WAPL CAND1 CAND2 RNPEPL1 ITPR1 AP2A1 VPS35 MROH7 AP1G2	8.58e-05	339	100	9	IPR016024
Domain	RIH_assoc-dom	RYR1 ITPR1	4.20e-04	6	100	2	IPR013662
Domain	Ins145_P3_rec	RYR1 ITPR1	4.20e-04	6	100	2	PF08709
Domain	RIH_assoc	RYR1 ITPR1	4.20e-04	6	100	2	PF08454
Domain	RIH_dom	RYR1 ITPR1	4.20e-04	6	100	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 ITPR1	4.20e-04	6	100	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 ITPR1	4.20e-04	6	100	2	IPR015925
Domain	-	RYR1 ITPR1	4.20e-04	6	100	2	1.25.10.30
Domain	RYDR_ITPR	RYR1 ITPR1	4.20e-04	6	100	2	PF01365
Domain	PyrdxlP-dep_de-COase	PDXDC1 SGPL1	7.78e-04	8	100	2	IPR002129
Domain	Pyridoxal_deC	PDXDC1 SGPL1	7.78e-04	8	100	2	PF00282
Domain	DDC_GAD_HDC_YDC	PDXDC1 SGPL1	7.78e-04	8	100	2	PS00392
Domain	Acyl-CoA_DH_CS	ACADL ACAD8	9.97e-04	9	100	2	IPR006089
Domain	Alpha_adaptinC2	AP2A1 AP1G2	9.97e-04	9	100	2	PF02883
Domain	Clathrin_a/b/g-adaptin_app_Ig	AP2A1 AP1G2	9.97e-04	9	100	2	IPR008152
Domain	Alpha_adaptinC2	AP2A1 AP1G2	9.97e-04	9	100	2	SM00809
Domain	MIR	RYR1 ITPR1	1.24e-03	10	100	2	PF02815
Domain	MIR_motif	RYR1 ITPR1	1.24e-03	10	100	2	IPR016093
Domain	ACYL_COA_DH_1	ACADL ACAD8	1.24e-03	10	100	2	PS00072
Domain	ACYL_COA_DH_2	ACADL ACAD8	1.24e-03	10	100	2	PS00073
Domain	MIR	RYR1 ITPR1	1.24e-03	10	100	2	PS50919
Domain	MIR	RYR1 ITPR1	1.24e-03	10	100	2	SM00472
Domain	GAIN_dom_N	ADGRB2 CELSR3	1.51e-03	11	100	2	IPR032471
Domain	Acyl-CoA_dh_N	ACADL ACAD8	1.51e-03	11	100	2	PF02771
Domain	GAIN	ADGRB2 CELSR3	1.51e-03	11	100	2	PF16489
Domain	Coatomer/clathrin_app_Ig-like	AP2A1 AP1G2	1.81e-03	12	100	2	IPR013041
Domain	-	ACADL ACAD8	2.13e-03	13	100	2	1.10.540.10
Domain	Acyl-CoA_dh_1	ACADL ACAD8	2.13e-03	13	100	2	PF00441
Domain	AcylCoA_DH/ox_N	ACADL ACAD8	2.13e-03	13	100	2	IPR013786
Domain	Znf_C3HC4_RING-type	RNF130 TRIM73 RNF112 CBL TRIM74	2.33e-03	172	100	5	IPR018957
Domain	Clathrin/coatomer_adapt-like_N	AP2A1 AP1G2	2.85e-03	15	100	2	IPR002553
Domain	Acyl-CoA_Oxase/DH_cen-dom	ACADL ACAD8	2.85e-03	15	100	2	IPR006091
Domain	AcylCoA_DH/oxidase_NM_dom	ACADL ACAD8	2.85e-03	15	100	2	IPR009100
Domain	Adaptin_N	AP2A1 AP1G2	2.85e-03	15	100	2	PF01602
Domain	Acyl-CoA_dh_M	ACADL ACAD8	2.85e-03	15	100	2	PF02770
Domain	AcylCo_DH/oxidase_C	ACADL ACAD8	3.24e-03	16	100	2	IPR009075
Domain	Leu-rich_rpt_Cys-con_subtyp	FBXL13 FBXL17	4.57e-03	19	100	2	IPR006553
Domain	LRR_CC	FBXL13 FBXL17	4.57e-03	19	100	2	SM00367
Domain	CBS_dom	CNNM4 CLCN2	5.06e-03	20	100	2	IPR000644
Domain	CBS	CNNM4 CLCN2	5.06e-03	20	100	2	PF00571
Domain	CBS	CNNM4 CLCN2	5.06e-03	20	100	2	PS51371
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	PDXDC1 CLSTN3 WAPL CAND1 CAND2 RPLP1 PLXNB2 ERLIN1 SLC25A22 CNNM4 AP2A1 DNAJC11 VPS35 PES1 SEC24B ASCC3 VDAC3	2.19e-09	942	102	17	31073040
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	CDK18 GRIPAP1 CAND2 MYO19 UBE3B SPIRE1 PRPF8 DIS3 ERLIN1 PTOV1 LPIN3 CNNM4 AP2A1 SEC24B UQCC1 CAMSAP2 VDAC3	2.92e-07	1321	102	17	27173435
Pubmed	Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression.	TRIM73 NBAS TRIM74	8.50e-07	7	102	3	26025256
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DNHD1 WAPL CAND1 RPLP1 GRM1 PRPF8 DIS3 RIOX2 SLC25A22 AP2A1 DNAJC11 VPS35 PES1 CCAR1 CHST2 VDAC3	3.96e-06	1425	102	16	30948266
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CAND1 FAM76B SPIRE1 ERLIN1 RIOX2 GLG1 SGPL1 DNAJC11 PES1 SEC24B CCAR1 ASCC3 MBD4 CAMSAP2 ZMYM4 VDAC3	7.37e-06	1497	102	16	31527615
Pubmed	Long-term potentiation and long-term depression in hippocampal CA1 neurons of mice lacking the IP(3) type 1 receptor.	RYR1 ITPR1	8.52e-06	2	102	2	12654335
Pubmed	Expression and reconstitution of the bioluminescent Ca(2+) reporter aequorin in human embryonic stem cells, and exploration of the presence of functional IP3 and ryanodine receptors during the early stages of their differentiation into cardiomyocytes.	RYR1 ITPR1	8.52e-06	2	102	2	27430888
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	WAPL CAND1 MYO19 PRPF8 DIS3 ERLIN1 SLC25A22 AP2A1 SGPL1 VPS35 PES1 SEC24B CCAR1 AP1G2 ASCC3	9.54e-06	1353	102	15	29467282
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	PDXDC1 CAND1 CAND2 MYO19 DIS3 ERLIN1 SLC25A22 DNAJC11 VPS35 VDAC3	1.21e-05	606	102	10	36538041
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	WAPL CAND2 FRMPD1 FAM76B SPIRE1 DIS3 ERLIN1 ITPR1 GLG1 SGPL1 ROCK1 EXOC3L1 PHACTR1	1.75e-05	1084	102	13	11544199
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	CAND1 CAND2 RPLP1 MYO19 PRPF8 DIS3 ERLIN1 ITPR1 CNNM4 NBAS SGPL1 VPS35 PES1 ASCC3 VDAC3	1.98e-05	1440	102	15	30833792
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	PDXDC1 ACADL AUH PRPF8 CBL PLXNB2 DIS3 ITPR1 SLC25A22 GLG1 SGPL1 VPS35 SEC24B CFAP44 MOCS1	2.16e-05	1451	102	15	30550785
Pubmed	Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.	SVEP1 CNNM4 TENM4	2.29e-05	19	102	3	18711365
Pubmed	TIP120B: a novel TIP120-family protein that is expressed specifically in muscle tissues.	CAND1 CAND2	2.55e-05	3	102	2	10441524
Pubmed	ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL.	WAPL ESCO1	2.55e-05	3	102	2	32065581
Pubmed	Gene structure variation in segmental duplication block C of human chromosome 7q 11.23 during primate evolution.	TRIM73 TRIM74	2.55e-05	3	102	2	26196062
Pubmed	TBP-interacting protein 120B, which is induced in relation to myogenesis, binds to NOT3.	CAND1 CAND2	2.55e-05	3	102	2	12207886
Pubmed	ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing the type I interferon response via CAND1-mediated ubiquitination inhibition of STAT3.	CAND1 ASCC3	2.55e-05	3	102	2	38148115
Pubmed	Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.	RYR1 ITPR1	2.55e-05	3	102	2	23223241
Pubmed	Intracellular calcium release channel expression during embryogenesis.	RYR1 ITPR1	2.55e-05	3	102	2	9986730
Pubmed	TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells.	TRIM73 TRIM74	2.55e-05	3	102	2	22872646
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	PDXDC1 CAND1 CAND2 PRPF8 DIS3 ERLIN1 PTOV1 CNNM4 AP2A1 DNAJC11 VPS35 ASCC3	2.91e-05	974	102	12	28675297
Pubmed	Co-adaptor driven assembly of a CUL3 E3 ligase complex.	CAND1 FBXL17 SEC24B	3.62e-05	22	102	3	35120648
Pubmed	Decreased GZMB, NRP1, ITPR1, and SERPINB9 Transcripts Lead to Reduced Regulatory T Cells Suppressive Capacity in Generalized Vitiligo Patients.	ITPR1 SERPINB9	5.09e-05	4	102	2	36157881
Pubmed	AAGAB Controls AP2 Adaptor Assembly in Clathrin-Mediated Endocytosis.	AP2A1 AP1G2	5.09e-05	4	102	2	31353312
Pubmed	An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors.	ERLIN1 ITPR1	5.09e-05	4	102	2	19240031
Pubmed	The erlin2 T65I mutation inhibits erlin1/2 complex-mediated inositol 1,4,5-trisphosphate receptor ubiquitination and phosphatidylinositol 3-phosphate binding.	ERLIN1 ITPR1	5.09e-05	4	102	2	30135210
Pubmed	Binding of the erlin1/2 complex to the third intralumenal loop of IP3R1 triggers its ubiquitin-proteasomal degradation.	ERLIN1 ITPR1	5.09e-05	4	102	2	35568199
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 ITPR1	5.09e-05	4	102	2	23413940
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 ITPR1	5.09e-05	4	102	2	9607712
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	RYR1 ITPR1	5.09e-05	4	102	2	19120137
Pubmed	RNA ligase-like domain in activating signal cointegrator 1 complex subunit 1 (ASCC1) regulates ASCC complex function during alkylation damage.	PRPF8 ASCC3	5.09e-05	4	102	2	29997253
Pubmed	Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells.	GRM1 ITPR1	5.09e-05	4	102	2	18480293
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DNHD1 PRPF8 LPIN3 VPS35 PES1 CCAR1	6.84e-05	234	102	6	36243803
Pubmed	Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase.	TRIM73 TRIM74	8.47e-05	5	102	2	18398435
Pubmed	Intracellular calcium-release channels: regulators of cell life and death.	RYR1 ITPR1	8.47e-05	5	102	2	9124414
Pubmed	Breakpoint features of genomic rearrangements in neuroblastoma with unbalanced translocations and chromothripsis.	NBAS TENM4	8.47e-05	5	102	2	23991058
Pubmed	Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice.	TRIM73 TRIM74	8.47e-05	5	102	2	20049703
Pubmed	Cloning and characterization of Cbl-associated protein splicing isoforms.	CBL SERPINB9	8.47e-05	5	102	2	12765336
Pubmed	Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.	CAND1 PRPF8 ERLIN1 SLC25A22 AP2A1 DNAJC11	8.61e-05	244	102	6	28902428
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CLSTN3 WAPL CAND1 DNAAF9 PRPF8 ODF2L FRY ACAD8 CELSR3 AP2A1 CCAR1 MBD4 ZMYM4	9.97e-05	1285	102	13	35914814
Pubmed	Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes.	AP2A1 AP1G2	1.27e-04	6	102	2	22650988
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 ITPR1	1.27e-04	6	102	2	23463619
Pubmed	Cohesin acetylation speeds the replication fork.	WAPL ESCO1	1.27e-04	6	102	2	19907496
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 ITPR1	1.27e-04	6	102	2	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 ITPR1	1.27e-04	6	102	2	25966694
Pubmed	TRIM50 regulates Beclin 1 proautophagic activity.	TRIM73 TRIM74	1.27e-04	6	102	2	29604308
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 ITPR1	1.27e-04	6	102	2	16844763
Pubmed	TRIM50 promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization.	TRIM73 TRIM74	1.27e-04	6	102	2	36178239
Pubmed	Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.	GRM1 ITPR1	1.27e-04	6	102	2	9808459
Pubmed	Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development.	CAND1 ERLIN1 VPS35 PES1	1.47e-04	90	102	4	28978906
Pubmed	The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation.	CAND1 CAND2	1.77e-04	7	102	2	21169563
Pubmed	Epidemiology of the antibiotic resistance of Helicobacter pylori in Canada.	WAPL ESCO1	1.77e-04	7	102	2	11111111
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 ITPR1	1.77e-04	7	102	2	11860456
Pubmed	Synergistic activation of steroidogenic acute regulatory protein expression and steroid biosynthesis by retinoids: involvement of cAMP/PKA signaling.	STAR PGR	1.77e-04	7	102	2	24265455
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	IQSEC3 CAND1 ADGRB2 GRM1 AP2A1 PHACTR1	1.86e-04	281	102	6	28706196
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	FAM76B PRPF8 CBL PLXNB2 ERLIN1 AP2A1 GLG1 SGPL1 VPS35 PES1 UQCC1 ZMYM4	2.14e-04	1203	102	12	29180619
Pubmed	An ENU-mutagenesis screen in the mouse: identification of novel developmental gene functions.	PLXNB2 SEC24B	2.36e-04	8	102	2	21559415
Pubmed	A HECT domain E3 enzyme assembles novel polyubiquitin chains.	CAND1 CAND2	2.36e-04	8	102	2	11278995
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	CDK18 FRMPD1 ADGRB2 SGPL1 DNAJC11 CAMSAP2 VDAC3	2.83e-04	430	102	7	32581705
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	IQSEC3 CAND1 RPLP1 ACADL SPIRE1 GRM1 SLC25A22 TENM4 AP2A1 SGPL1 VPS35 CAMSAP2 VDAC3	2.86e-04	1431	102	13	37142655
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	PDXDC1 CAND1 CAND2 PRPF8 DIS3 ERLIN1 PTOV1 SLC25A22 DNAJC11 PES1 ASCC3 VDAC3	3.19e-04	1257	102	12	37317656
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	MYO19 RNF112 PRPF8 ESCO1 RYR1 RIOX2 FRY EDAR CFAP44	3.22e-04	736	102	9	29676528
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	RNF112 PRPF8 NBAS MROH7 ASCC3	3.32e-04	202	102	5	33005030
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	CAND1 FAM76B PHETA1 ERLIN1 SLC25A22 FAM13A AP2A1 DNAJC11 CCAR1 VDAC3	3.67e-04	916	102	10	32203420
Pubmed	Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain.	GRM1 ITPR1	3.77e-04	10	102	2	15579147
Pubmed	Ring finger protein20 regulates hepatic lipid metabolism through protein kinase A-dependent sterol regulatory element binding protein1c degradation.	RNF130 CCAR1	3.77e-04	10	102	2	24425205
Pubmed	Sororin mediates sister chromatid cohesion by antagonizing Wapl.	WAPL ESCO1	3.77e-04	10	102	2	21111234
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	RNPEPL1 UBE3B ADGRB2 SPIRE1 PLXNB2 RYR1 LPIN3 SLC25A22 CELSR3 AP2A1 AP1G2	4.04e-04	1105	102	11	35748872
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RNF130 CAND1 FRMPD1 FBXL17 SPIRE1 PFKFB1 ZSWIM1 ESCO1 CNNM4 ODF2L FAM13A CCAR1 ZMYM4	4.17e-04	1489	102	13	28611215
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	PDXDC1 CAND1 PRPF8 PLXNB2 ERLIN1 SLC25A22 AP2A1 GLG1 PES1 SEC24B CCAR1 VDAC3	4.22e-04	1297	102	12	33545068
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	WAPL CAND1 RPLP1 PRPF8 DIS3 ERLIN1 AP2A1 DNAJC11 PES1 CCAR1 ASCC3 VDAC3	4.87e-04	1318	102	12	30463901
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	CDK18 ACADL AUH MYO19 STAR SLC25A22 ACAD8 DNAJC11 UQCC1 MOCS1 VDAC3	5.09e-04	1136	102	11	34800366
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	IQSEC3 CAND1 ADGRB2 GRM1 FRY AP2A1 CCAR1 ROCK1 CAMSAP2 PHACTR1	5.41e-04	963	102	10	28671696
Pubmed	A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells.	PHETA1 AP2A1	5.51e-04	12	102	2	25107275
Pubmed	Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.	CAND1 ACADL GLG1 ASCC3 VDAC3	5.53e-04	226	102	5	37839992
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	CAND1 PRPF8 CNNM4 VPS35 SEC24B ASCC3 VDAC3	5.73e-04	484	102	7	31995728
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	CAND1 PRPF8 ROCK1 ASCC3	5.80e-04	129	102	4	23022380
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	WAPL PRPF8 ESCO1 ITPR1 NBAS ODF2L ACAD8 AP2A1 CCAR1 ZMYM4 VDAC3	5.84e-04	1155	102	11	20360068
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	PDXDC1 CAND1 PRPF8 DIS3 VPS35 PES1 CCAR1 ASCC3	5.94e-04	638	102	8	33239621
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	PDXDC1 CAND1 ACADL PRPF8 RYR1 NBAS AP2A1 GLG1 VDAC3	6.25e-04	807	102	9	30575818
Pubmed	Defining the membrane proteome of NK cells.	CAND1 PRPF8 DIS3 ITPR1 NBAS SERPINB9 AP2A1 GLG1 CD37 PES1 ASCC3	6.41e-04	1168	102	11	19946888
Pubmed	Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression.	CAND1 CAND2	6.50e-04	13	102	2	29499133
Pubmed	Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins.	ADGRB2 ITPR1	6.50e-04	13	102	2	14697242
Pubmed	EphrinA2 regulates clathrin mediated KSHV endocytosis in fibroblast cells by coordinating integrin-associated signaling and c-Cbl directed polyubiquitination.	CBL AP2A1	6.50e-04	13	102	2	23874206
Pubmed	Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins.	AP2A1 AP1G2	6.50e-04	13	102	2	9882340
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	WAPL RPLP1 PRPF8 DIS3 ERLIN1 RIOX2 PTOV1 PES1 CCAR1 VDAC3	6.64e-04	989	102	10	36424410
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	WAPL MYO19 UBE3B DIS3 ITPR1 LPIN3 SGPL1 CCAR1	6.70e-04	650	102	8	38777146
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	DIS3 ERLIN1 ITPR1 SERPINB9 RASGRP3 MOCS1	7.20e-04	363	102	6	14691545
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	PDXDC1 GRIPAP1 ITPR1 NBAS SGPL1 VPS35 SEC24B	7.27e-04	504	102	7	34432599
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	CDK18 CAND1 PRPF8 SGPL1 VPS35 PES1 CCAR1 VDAC3	7.77e-04	665	102	8	30457570
Pubmed	Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases.	CAND1 CAND2 FBXL17	8.17e-04	62	102	3	29103612
Pubmed	Evolutionarily conserved regulators of tau identify targets for new therapies.	PDXDC1 RNF130 ERLIN1 GLG1 SGPL1 VPS35 SEC24B	8.34e-04	516	102	7	36610398
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	WAPL CAND1 CAND2 SPIRE1 DIS3 CELSR3 ZMYM4	9.64e-04	529	102	7	14621295
Pubmed	Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance.	CELSR3 AP2A1	9.95e-04	16	102	2	24305805
Pubmed	HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation.	AP2A1 AP1G2	9.95e-04	16	102	2	21762802
Pubmed	The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome.	TRIM73 TRIM74	9.95e-04	16	102	2	22792322
Pubmed	Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty.	PGR EDAR	9.95e-04	16	102	2	28698625
Pubmed	SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.	ERLIN1 DNAJC11 PES1 ZMYM4	1.02e-03	150	102	4	30154076
Pubmed	Mutation specific functions of EGFR result in a mutation-specific downstream pathway activation.	CAND2 CBL AP2A1	1.07e-03	68	102	3	25754235
Interaction	LMBR1L interactions	PDXDC1 CLSTN3 WAPL CAND1 CAND2 RPLP1 PLXNB2 ERLIN1 SLC25A22 CNNM4 AP2A1 DNAJC11 VPS35 PES1 SEC24B ASCC3 VDAC3	3.31e-06	946	99	17	int:LMBR1L
Interaction	FGFR4 interactions	PDXDC1 RNF130 GRIPAP1 GRM1 CBL ERLIN1 LYPD1 EDAR SEC24B PSMC3IP UQCC1	1.55e-05	458	99	11	int:FGFR4
GeneFamily	Acyl-CoA dehydrogenase family	ACADL ACAD8	6.65e-04	11	64	2	974
Drug	Boldine [476-70-0]; Down 200; 12.2uM; PC3; HT_HG-U133A	RNPEPL1 UBE3B ITPR1 CNNM4 FAM13A GLG1 CUZD1 MOCS1	2.87e-06	198	101	8	4004_DN
Disease	creatinine measurement	CDK18 CAND1 CAND2 RNF112 FBXL17 PLXNB2 RYR1 FRY CELSR3 ASCC3 MBD4	5.11e-04	995	99	11	EFO_0004518
Disease	lysophosphatidylcholine measurement	PDXDC1 ESCO1 ROCK1	1.20e-03	62	99	3	EFO_0010224
Disease	level of Sterol ester (27:1/20:3) in blood serum	PDXDC1 PPBP	1.84e-03	19	99	2	OBA_2045199
Disease	polycystic ovary syndrome (biomarker_via_orthology)	STAR PGR	2.24e-03	21	99	2	DOID:11612 (biomarker_via_orthology)
Disease	level of Phosphatidylcholine (16:1_18:2) in blood serum	ESCO1 ROCK1	2.24e-03	21	99	2	OBA_2045083

Protein segments in the cluster

Peptide	Gene	Start	Entry
IAAKYMLDCRTSLSA	VDAC3	221	Q9Y277
AVSCMALLTLLAIYA	ADGRB2	941	O60241
TCSLESRLKSVMQSY	EXOC3L1	61	Q86VI1
VMRCLLAYFLDKSSD	PFKFB1	396	P16118
GCMTAAEISKYLTLS	ARL5B	131	Q96KC2
AALYTRKFRLSCSEM	CLSTN3	771	Q9BQT9
DAVALCSMAKLFATD	ACAD8	346	Q9UKU7
EAKRLDSATACMAKY	ACADL	356	P28330
KFDCSIMSLSVLLDY	CCAR1	741	Q8IX12
LLYESKSRMSAEAAL	CDK18	406	Q07002
MFVDSSCALKYSDIR	ERLIN1	306	O75477
CSMLGRKIAALYDSF	ABHD12B	41	Q7Z5M8
YALTALMKLSTRLCG	AP1G2	526	O75843
RYLALESMCTLASSE	AP2A1	346	O95782
CLYLSTTLSLCAMEK	DNHD1	3721	Q96M86
LTYLMATTALDCSVR	CFAP44	481	Q96MT7
YAKNSRASLRKCSVM	MROH7	1206	Q68CQ1
LDMLCYISSEKTTLA	ODF2L	371	Q9ULJ1
SALTLCYMIIRATAS	RNF130	396	Q86XS8
DIIYSLITSCNMSKR	ACKR4	266	Q9NPB9
SSEELKAAYRRLCML	DNAJC11	26	Q9NVH1
LYCSARAIGMADLTK	LPIN3	686	Q9BQK8
LKLSCTDTSLYETLM	OR2T2	186	Q6IF00
IRTCTSIMEKDLTYS	GPR82	231	Q96P67
SCRYMEAELKELSSA	PSMC3IP	106	Q9P2W1
LDYLSDLCVSMNKSI	ITPR1	631	Q14643
TSRCLMKFYAVVATS	MYO19	141	Q96H55
ALACDIRVAASSAKM	AUH	191	Q13825
DCLEKTSRMLSSTYN	EDAR	351	Q9UNE0
IRKAAFECMYTLLDS	CAND1	1081	Q86VP6
RCTMKTLTETDLYCE	PLXNB2	1136	O15031
YVSSSVLAAAKCDSM	PDXDC1	281	Q6P996
YVSSSVLAAAKCDSM	PDXDC2P	281	Q6P474
YTSMSDCLIKTVRSE	SLC25A22	46	Q9H936
MLKEIRYASGASCLA	KLHL41	581	O60662
MAASALYACTKCTQR	FAM76B	1	Q5HYJ3
ALATAECLLLAAMAY	OR13H1	106	Q8NG92
MASVSELACIYSALI	RPLP1	1	P05386
RLSYRKACLEDMNSA	FAM13A	311	O94988
SLKTMCSLRESGAYQ	IQSEC3	421	Q9UPP2
RLLMNSCSEDKYVTS	NBAS	916	A2RRP1
LGMAVSSDTCRSLKY	COMMD6	26	Q7Z4G1
SAAVAALTLYDMCKA	MOCS1	596	Q9NZB8
ALTLYDMCKAVSRDI	MOCS1	601	Q9NZB8
KASCEIRVLMLLYSS	PTOV1	356	Q86YD1
DSSLYTSSLAMKVCR	PHACTR1	406	Q9C0D0
EQRMKESSFYSLCLT	PGR	786	P06401
MFVSKSLRCADDVAY	GSKIP	51	Q9P0R6
TKMTAIIFSDYRLIC	GLG1	221	Q92896
YATEQSFSCAKRALM	CPHXL2	116	A0A1W2PPK0
FAVEMKCSSALRLAA	FRMPD1	296	Q5SYB0
SSKSLRYLGLMRCDK	FBXL17	641	Q9UF56
SLSFVKTACMAVYDI	DNAAF9	446	Q5TEA3
IYMADCKGITDSSLR	FBXL13	431	Q8NEE6
IKSRYKDCSMAALTS	MBD4	151	O95243
MYRKSCASSAACLIA	LYPD1	66	Q8N2G4
AMALKSTIDLTCNDY	CBL	221	P22681
MCYSRTKTLLFISND	ESCO1	701	Q5FWF5
SVSLALLSCELARMY	FRY	1316	Q5TBA9
TCSSDRMRVIISKSY	CUZD1	276	Q86UP6
NYMKCVSVLRFDSSA	CELSR3	1386	Q9NYQ7
RLLVGLSSAMCYSAL	GRM1	661	Q13255
SMASLACISIDRYIA	GPR21	116	Q99679
SASMAEDLCRKSAII	GRIPAP1	736	Q4V328
VRKAAFECMYSLLES	CAND2	1086	O75155
LLSSQYSDLASLACM	SEC24B	866	O95487
YLSCLTTSRSMTDKL	RYR1	116	P21817
CLKETMSLADSLYNL	CAMSAP2	276	Q08AD1
DLYAELRCMCIKTTS	PPBP	56	P02775
MSAQESCLSLIKYFL	CD37	1	P11049
VPAMLKLSCADTTRY	OR2AJ1	181	Q8NGZ0
EVVMSLSKCYSSLLD	RNPEPL1	581	Q9HAU8
LSKCYSSLLDSMNAE	RNPEPL1	586	Q9HAU8
MKLNERSLAFYATCD	PHETA1	1	Q8N4B1
LSSTELAEKLLCMYR	RASGRP3	46	Q8IV61
KSQERSMSYCDESRL	nan	131	Q6P435
LACSDTYNKELSMFI	OR5M8	186	Q8NGP6
CSTREMLYKTTCLVA	SVEP1	451	Q4LDE5
YCGMLSKSDIKESRR	DIS3	356	Q9Y2L1
TESILMACKAYRDLA	SGPL1	211	O95470
DLCCTLYDMLASIKS	ASCC3	246	Q8N3C0
ARDMLSALYRCDLSV	CHST2	216	Q9Y4C5
IASMCAALLSKFLSL	CLCN2	211	P51788
RSESMKLYALCTRAQ	CNNM4	141	Q6P4Q7
KMNSSCADILLFASY	PRPF8	1621	Q6P2Q9
STVCSRMKEELAALF	TRIM74	126	Q86UV6
YRNLVSLDISSKCTM	ZNF761	41	Q86XN6
SCMEKLAALSASLAR	PES1	271	O00541
RIKLCALTTMLSSYQ	RNF112	261	Q9ULX5
SAMSAERDLCLSKFV	SERPINB9	301	P50453
MLLATFKLCAGSSYR	STAR	1	P49675
ESRKSMSCYVLSNVL	VPS35	431	Q96QK1
SMCARLDTIISKYPA	STPG1	96	Q5TH74
SAIRSYRDVMKLCAA	SPIRE1	191	Q08AE8
KTCSVLYNFSLTDRM	TMPRSS9	656	Q7Z410
LSLCTAALMYILSRD	WAPL	716	Q7Z5K2
IMERLKSYDLECSTL	ZNF470	121	Q6ECI4
EISISGCKMRLSYLS	TENM4	1051	Q6N022
AALRMYTSCVEKTDF	UQCC1	116	Q9NVA1
LCEAMKANTYVRSFS	TMOD4	216	Q9NZQ9
FKLTDLKSLCSRGMY	RIOX2	81	Q8IUF8
SYDVTSARDMLLLAC	ROCK1	1286	Q13464
FEKLCRSILSSMDAE	UBE3B	96	Q7Z3V4
STVCSRMKEELAALF	TRIM73	126	Q86UV7
TMCSATAGNLRKLYT	ZSWIM1	201	Q9BR11
CLSAYRVKMVTSAGV	ZMYM4	561	Q5VZL5