Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	SOX3 ATMIN ONECUT2 SP9 TBX3 E2F3 POU3F3 OTP POU6F2 OTX1 FOXL2 NKX2-4 MAZ	1.52e-05	1412	47	13	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	SOX3 ONECUT2 SP9 GTF2A1 TBX3 E2F3 POU3F3 OTP POU6F2 OTX1 FOXL2 NKX2-4 MAZ	2.15e-05	1459	47	13	GO:0000977
GeneOntologyMolecularFunction	regulatory region RNA binding	PTBP1 MBNL1	5.40e-05	5	47	2	GO:0001069
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	SOX3 ONECUT2 SP9 TBX3 E2F3 POU3F3 POU6F2 OTX1 FOXL2 NKX2-4 MAZ	1.14e-04	1244	47	11	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	SOX3 ONECUT2 SP9 TBX3 E2F3 POU3F3 POU6F2 OTX1 FOXL2 NKX2-4 MAZ	1.38e-04	1271	47	11	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	SOX3 ATMIN ONECUT2 TBX3 E2F3 OTX1 FOXL2	3.12e-04	560	47	7	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	SOX3 ATMIN ONECUT2 TBX3 E2F3 OTX1 FOXL2	3.33e-04	566	47	7	GO:0001216
GeneOntologyMolecularFunction	nucleosome binding	MLLT6 ARID1B CHD4	1.59e-03	98	47	3	GO:0031491
GeneOntologyMolecularFunction	chromatin binding	PWWP2A MLLT6 ARID1B CHD4 TRIM28 TLE4 MAZ	1.60e-03	739	47	7	GO:0003682
GeneOntologyMolecularFunction	transcription factor binding	GTF2A1 TBX3 DDX20 CHD4 FOXL2 USP11 TLE4	1.78e-03	753	47	7	GO:0008134
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	GTF2A1 TBX3 DDX20 CHD4 FOXL2 TLE4	2.32e-03	582	47	6	GO:0140297
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	SOX3 ATMIN ONECUT2 PWWP2A GTF2A1 MLLT6 TBX3 E2F3 POU3F3 OTX1 FOXL2 PTBP1 MAZ	9.05e-06	1390	47	13	GO:0045944
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	SOX3 TBX3 POU3F3 OTP DDX20 CHD4 FOXL2 TRIM28 TLE4 MAZ MAGEB18	1.86e-05	1053	47	11	GO:0000122
GeneOntologyBiologicalProcess	transcription initiation at RNA polymerase II promoter	PWWP2A GTF2A1 E2F3 ARID1B MAZ	6.38e-05	186	47	5	GO:0006367
GeneOntologyBiologicalProcess	DNA-templated transcription initiation	PWWP2A GTF2A1 E2F3 ARID1B MAZ	1.76e-04	231	47	5	GO:0006352
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	SOX3 TBX3 POU3F3 OTP DDX20 CHD4 FOXL2 TRIM28 TLE4 MAZ MAGEB18	2.41e-04	1399	47	11	GO:0045892
GeneOntologyBiologicalProcess	myoblast differentiation	TBX3 ARID1B MBNL1 GPX1	2.59e-04	136	47	4	GO:0045445
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	SOX3 TBX3 POU3F3 OTP DDX20 CHD4 FOXL2 TRIM28 TLE4 MAZ MAGEB18	2.63e-04	1413	47	11	GO:1902679
GeneOntologyBiologicalProcess	follicle-stimulating hormone secretion	TBX3 FOXL2	2.76e-04	11	47	2	GO:0046884
GeneOntologyBiologicalProcess	regulation of alternative mRNA splicing, via spliceosome	PTBP1 MBNL2 MBNL1	3.30e-04	59	47	3	GO:0000381
GeneOntologyCellularComponent	chromatin	SOX3 ONECUT2 SP9 TBX3 E2F3 POU3F3 OTP POU6F2 ARID1B CHD4 OTX1 FOXL2 INCENP NKX2-4 TRIM28	4.53e-07	1480	47	15	GO:0000785
GeneOntologyCellularComponent	transcription regulator complex	GTF2A1 TBX3 E2F3 DDX20 CHD4 TRIM28 TLE4	3.45e-04	596	47	7	GO:0005667
GeneOntologyCellularComponent	RNA polymerase II transcription regulator complex	GTF2A1 E2F3 CHD4 TRIM28 TLE4	3.53e-04	272	47	5	GO:0090575
Domain	Homeobox	ONECUT2 POU3F3 OTP POU6F2 OTX1 NKX2-4	1.96e-05	234	45	6	PF00046
Domain	HOMEOBOX_1	ONECUT2 POU3F3 OTP POU6F2 OTX1 NKX2-4	2.06e-05	236	45	6	PS00027
Domain	HOX	ONECUT2 POU3F3 OTP POU6F2 OTX1 NKX2-4	2.11e-05	237	45	6	SM00389
Domain	Homeobox_dom	ONECUT2 POU3F3 OTP POU6F2 OTX1 NKX2-4	2.21e-05	239	45	6	IPR001356
Domain	HOMEOBOX_2	ONECUT2 POU3F3 OTP POU6F2 OTX1 NKX2-4	2.21e-05	239	45	6	PS50071
Domain	-	ONECUT2 POU3F3 POU6F2	3.67e-05	27	45	3	1.10.260.40
Domain	Lambda_DNA-bd_dom	ONECUT2 POU3F3 POU6F2	4.57e-05	29	45	3	IPR010982
Domain	-	ONECUT2 POU3F3 OTP POU6F2 OTX1 NKX2-4	5.69e-05	283	45	6	1.10.10.60
Domain	Homeodomain-like	ONECUT2 POU3F3 OTP POU6F2 OTX1 NKX2-4	1.37e-04	332	45	6	IPR009057
Domain	Zinc_finger_PHD-type_CS	MLLT6 CHD4 TRIM28	5.14e-04	65	45	3	IPR019786
Domain	POU	POU3F3 POU6F2	6.67e-04	16	45	2	SM00352
Domain	POU_2	POU3F3 POU6F2	6.67e-04	16	45	2	PS00465
Domain	Pou	POU3F3 POU6F2	6.67e-04	16	45	2	PF00157
Domain	POU_dom	POU3F3 POU6F2	6.67e-04	16	45	2	IPR000327
Domain	POU_3	POU3F3 POU6F2	6.67e-04	16	45	2	PS51179
Domain	POU_1	POU3F3 POU6F2	6.67e-04	16	45	2	PS00035
Domain	POU	POU3F3 POU6F2	7.54e-04	17	45	2	IPR013847
Domain	PHD	MLLT6 CHD4 TRIM28	7.82e-04	75	45	3	PF00628
Domain	Znf_PHD-finger	MLLT6 CHD4 TRIM28	9.09e-04	79	45	3	IPR019787
Domain	Homeobox_CS	POU3F3 OTP OTX1 NKX2-4	1.03e-03	186	45	4	IPR017970
Domain	PHD	MLLT6 CHD4 TRIM28	1.28e-03	89	45	3	SM00249
Domain	Znf_PHD	MLLT6 CHD4 TRIM28	1.37e-03	91	45	3	IPR001965
Domain	ZF_PHD_2	MLLT6 CHD4 TRIM28	1.55e-03	95	45	3	PS50016
Domain	ZF_PHD_1	MLLT6 CHD4 TRIM28	1.60e-03	96	45	3	PS01359
Domain	-	MBNL2 MBNL1	4.18e-03	40	45	2	4.10.1000.10
Domain	Znf_FYVE_PHD	MLLT6 CHD4 TRIM28	5.32e-03	147	45	3	IPR011011
Domain	ZnF_C3H1	MBNL2 MBNL1	5.97e-03	48	45	2	SM00356
Domain	zf-CCCH	MBNL2 MBNL1	6.21e-03	49	45	2	PF00642
Domain	Znf_CCCH	MBNL2 MBNL1	8.61e-03	58	45	2	IPR000571
Domain	ZF_C3H1	MBNL2 MBNL1	8.61e-03	58	45	2	PS50103
Domain	HMG_box_dom	SOX3 CHD4	1.07e-02	65	45	2	IPR009071
Domain	Prefoldin	AMOT TLE4	1.30e-02	72	45	2	IPR009053
Pubmed	A census of human transcription factors: function, expression and evolution.	SOX3 ONECUT2 SP9 TBX3 E2F3 POU3F3 OTP POU6F2 OTX1 FOXL2 NKX2-4 MAZ	2.10e-09	908	47	12	19274049
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	SOX3 ONECUT2 GTF2A1 MLLT6 TBX3 OTX1 DZIP1 NKX2-4 MBNL2 TRIM28 MBNL1	8.09e-09	808	47	11	20412781
Pubmed	Tbx2 and Tbx3 regulate cell fate progression of the otic vesicle for inner ear development.	SOX3 TBX3 POU3F3 OTX1	2.54e-08	23	47	4	36521641
Pubmed	Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse.	SOX3 TBX3 CHD4 OTX1 SOWAHA	2.81e-08	65	47	5	33795231
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	SOX3 ONECUT2 SP9 TBX3 E2F3 OTX1 FOXL2 MBNL2	6.26e-07	544	47	8	28473536
Pubmed	Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.	SP9 POU3F3 OTP OTX1 TLE4	1.06e-06	134	47	5	19030180
Pubmed	Distal Alternative Last Exons Localize mRNAs to Neural Projections.	MBNL2 MBNL1	1.79e-06	2	47	2	26907613
Pubmed	Mice lacking MBNL1 and MBNL2 exhibit sudden cardiac death and molecular signatures recapitulating myotonic dystrophy.	MBNL2 MBNL1	1.79e-06	2	47	2	35567413
Pubmed	MBNL proteins repress ES-cell-specific alternative splicing and reprogramming.	MBNL2 MBNL1	1.79e-06	2	47	2	23739326
Pubmed	Compound loss of muscleblind-like function in myotonic dystrophy.	MBNL2 MBNL1	1.79e-06	2	47	2	24293317
Pubmed	Zenglv Fumai Granule protects cardiomyocytes against hypoxia/reoxygenation-induced apoptosis via inhibiting TRIM28 expression.	TRIM28 GPX1	1.79e-06	2	47	2	33398366
Pubmed	Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis.	DDX20 FOXL2	1.79e-06	2	47	2	16153597
Pubmed	Alternative splicing mediates the compensatory upregulation of MBNL2 upon MBNL1 loss-of-function.	MBNL2 MBNL1	1.79e-06	2	47	2	36617982
Pubmed	MBNL Sequestration by Toxic RNAs and RNA Misprocessing in the Myotonic Dystrophy Brain.	MBNL2 MBNL1	1.79e-06	2	47	2	26257173
Pubmed	Optical Mapping Approaches on Muscleblind-Like Compound Knockout Mice for Understanding Mechanistic Insights Into Ventricular Arrhythmias in Myotonic Dystrophy.	MBNL2 MBNL1	1.79e-06	2	47	2	28416514
Pubmed	Opposing roles of miR-294 and MBNL1/2 in shaping the gene regulatory network of embryonic stem cells.	MBNL2 MBNL1	1.79e-06	2	47	2	29735517
Pubmed	Studying the Effect of MBNL1 and MBNL2 Loss in Skeletal Muscle Regeneration.	MBNL2 MBNL1	1.79e-06	2	47	2	38473933
Pubmed	Increased Muscleblind levels by chloroquine treatment improve myotonic dystrophy type 1 phenotypes in in vitro and in vivo models.	MBNL2 MBNL1	1.79e-06	2	47	2	31754023
Pubmed	Altered levels of the splicing factor muscleblind modifies cerebral cortical function in mouse models of myotonic dystrophy.	MBNL2 MBNL1	1.79e-06	2	47	2	29331264
Pubmed	Mbnl1 and Mbnl2 regulate brain structural integrity in mice.	MBNL2 MBNL1	1.79e-06	2	47	2	34848815
Pubmed	Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy.	MBNL2 MBNL1	1.79e-06	2	47	2	20098426
Pubmed	Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins.	MBNL2 MBNL1	1.79e-06	2	47	2	22901804
Pubmed	Tau exon 2 responsive elements deregulated in myotonic dystrophy type I are proximal to exon 2 and synergistically regulated by MBNL1 and MBNL2.	MBNL2 MBNL1	1.79e-06	2	47	2	24440524
Pubmed	Conserved developmental alternative splicing of muscleblind-like (MBNL) transcripts regulates MBNL localization and activity.	MBNL2 MBNL1	1.79e-06	2	47	2	20009516
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TBX3 C16orf96 ARID1B CHD4 SOWAHA TRIM28 USP11 MAZ KIF7 GPX1	1.95e-06	1116	47	10	31753913
Pubmed	Transcriptional regulation of cortical neuron migration by POU domain factors.	POU3F3 OTX1 TLE4	2.59e-06	20	47	3	11859196
Pubmed	Embryonic temporal-spatial delineation of excitatory spinal V3 interneuron diversity.	ONECUT2 OTP POU6F2	3.50e-06	22	47	3	38160393
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ONECUT2 GTF2A1 POU3F3 ARID1B CHD4 OTX1 PTBP1 TRIM28 AMOT MAZ	3.81e-06	1203	47	10	29180619
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	GTF2A1 TBX3 POU3F3 OTP CHD4 OTX1 TRIM28 MBNL1	4.47e-06	709	47	8	22988430
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	MLLT6 ARID1B CHD4 PTBP1 INCENP MBNL2 TRIM28 MAZ MBNL1	4.52e-06	954	47	9	36373674
Pubmed	Cascade diversification directs generation of neuronal diversity in the hypothalamus.	SOX3 TBX3 OTP	4.59e-06	24	47	3	33887179
Pubmed	Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy.	MBNL2 MBNL1	5.36e-06	3	47	2	27063795
Pubmed	Muscleblind-like proteins: similarities and differences in normal and myotonic dystrophy muscle.	MBNL2 MBNL1	5.36e-06	3	47	2	19095965
Pubmed	Loss of MBNL1 induces RNA misprocessing in the thymus and peripheral blood.	MBNL2 MBNL1	5.36e-06	3	47	2	32332745
Pubmed	Three proteins, MBNL, MBLL and MBXL, co-localize in vivo with nuclear foci of expanded-repeat transcripts in DM1 and DM2 cells.	MBNL2 MBNL1	5.36e-06	3	47	2	11929853
Pubmed	Muscleblind proteins regulate alternative splicing.	MBNL2 MBNL1	5.36e-06	3	47	2	15257297
Pubmed	Disrupted prenatal RNA processing and myogenesis in congenital myotonic dystrophy.	MBNL2 MBNL1	5.36e-06	3	47	2	28698297
Pubmed	RNA-dependent integrin alpha3 protein localization regulated by the Muscleblind-like protein MLP1.	MBNL2 MBNL1	5.36e-06	3	47	2	16273094
Pubmed	Loss of MBNL leads to disruption of developmentally regulated alternative polyadenylation in RNA-mediated disease.	MBNL2 MBNL1	5.36e-06	3	47	2	25263597
Pubmed	Sense and Antisense DMPK RNA Foci Accumulate in DM1 Tissues during Development.	MBNL2 MBNL1	5.36e-06	3	47	2	26339785
Pubmed	Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells.	SOX3 POU3F3 OTX1	5.88e-06	26	47	3	22992956
Pubmed	Physical interaction and functional coupling between ACDP4 and the intracellular ion chaperone COX11, an implication of the role of ACDP4 in essential metal ion transport and homeostasis.	CNNM1 RBM4B	1.07e-05	4	47	2	15840172
Pubmed	Developmental analysis of murine Promyelocyte Leukemia Zinc Finger (PLZF) gene expression: implications for the neuromeric model of the forebrain organization.	OTP OTX1	1.07e-05	4	47	2	7623123
Pubmed	Tripartite motif containing 28 (Trim28) can regulate cell proliferation by bridging HDAC1/E2F interactions.	E2F3 TRIM28	1.07e-05	4	47	2	23060449
Pubmed	Muscleblind-Like 1 and Muscleblind-Like 3 Depletion Synergistically Enhances Myotonia by Altering Clc-1 RNA Translation.	MBNL2 MBNL1	1.07e-05	4	47	2	26501102
Pubmed	Developmental expression of mouse muscleblind genes Mbnl1, Mbnl2 and Mbnl3.	MBNL2 MBNL1	1.07e-05	4	47	2	12915312
Pubmed	ABLIM1 splicing is abnormal in skeletal muscle of patients with DM1 and regulated by MBNL, CELF and PTBP1.	PTBP1 MBNL1	1.07e-05	4	47	2	25403273
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	TBX3 ARID1B CHD4 PTBP1 TRIM28	1.20e-05	220	47	5	35785414
Pubmed	The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.	ONECUT2 GTF2A1 ARID1B	1.23e-05	33	47	3	19336002
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	CHD4 OTX1 PTBP1 NKX2-4 TRIM28 USP11 MAZ	1.26e-05	583	47	7	29844126
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	DDX20 ARID1B USP11 RBM4B MAZ GPX1	1.56e-05	398	47	6	35016035
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	PWWP2A MLLT6 E2F3 CHD4 TRUB1 INCENP MAZ	1.65e-05	608	47	7	36089195
Pubmed	Human transcription factor protein interaction networks.	SP9 MLLT6 E2F3 ARID1B NKX2-4 USP11 TLE4 MAZ MBNL1 KIF7	1.71e-05	1429	47	10	35140242
Pubmed	Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development.	OTP OTX1	1.78e-05	5	47	2	17481897
Pubmed	Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain.	OTX1 TLE4	1.78e-05	5	47	2	12652306
Pubmed	miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models.	MBNL2 MBNL1	1.78e-05	5	47	2	29946070
Pubmed	Targeted splice sequencing reveals RNA toxicity and therapeutic response in myotonic dystrophy.	MBNL2 MBNL1	1.78e-05	5	47	2	33503262
Pubmed	Orthopedia, a novel homeobox-containing gene expressed in the developing CNS of both mouse and Drosophila.	OTP OTX1	1.78e-05	5	47	2	7913821
Pubmed	Dynamic balance between activation and repression regulates pre-mRNA alternative splicing during heart development.	PTBP1 MBNL1	1.78e-05	5	47	2	15830352
Pubmed	NKX2-5, a modifier of skeletal muscle pathology due to RNA toxicity.	MBNL2 MBNL1	1.78e-05	5	47	2	25168381
Pubmed	Non-coding RNA Neat1 and Abhd11os expressions are dysregulated in medium spiny neurons of Huntington disease model mice.	SMIM10L2A SMIM10L2B	1.78e-05	5	47	2	30391555
Pubmed	Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico.	TBX3 FOXL2 KIF7	2.04e-05	39	47	3	25859222
Pubmed	Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.	GTF2A1 OTX1 C1orf198 INCENP AMOT MAZ	2.26e-05	425	47	6	24999758
Pubmed	MBNL and CELF proteins regulate alternative splicing of the skeletal muscle chloride channel CLCN1.	MBNL2 MBNL1	2.67e-05	6	47	2	19720736
Pubmed	Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing.	MBNL2 MBNL1	2.67e-05	6	47	2	16946708
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	CHD4 PTBP1 TRIM28 USP11	2.85e-05	129	47	4	23022380
Pubmed	Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.	SP9 OTP OTX1 TLE4	2.93e-05	130	47	4	19386638
Pubmed	RNA Binding Protein Ptbp2 Is Essential for Male Germ Cell Development.	DZIP1 PTBP1	3.74e-05	7	47	2	26391954
Pubmed	Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis.	SOX3 TBX3 FOXL2	4.88e-05	52	47	3	23674600
Pubmed	Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II.	CHD4 TRIM28	4.98e-05	8	47	2	22308494
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ONECUT2 PWWP2A TBX3 CHD4 OTX1 FOXL2 PTBP1 TRIM28 MAZ	5.05e-05	1294	47	9	30804502
Pubmed	Precise temporal regulation of alternative splicing during neural development.	MBNL2 MBNL1	6.40e-05	9	47	2	29875359
Pubmed	Chromatin accessibility complex subunit 1 enhances tumor growth by regulating the oncogenic transcription of YAP in breast and cervical cancer.	CHD4 TRIM28 AMOT	6.43e-05	57	47	3	38223760
Pubmed	A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart.	PTBP1 MBNL2 MBNL1	7.50e-05	60	47	3	19075228
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	E2F3 ARID1B GGA2 SCFD1 DZIP1 AMOT	7.62e-05	529	47	6	14621295
Pubmed	Spinal Inhibitory Interneuron Diversity Delineates Variant Motor Microcircuits.	OTP POU6F2	7.99e-05	10	47	2	26949184
Pubmed	DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization.	DDX20 PTBP1 TRIM28 USP11	9.33e-05	175	47	4	25756610
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	GTF2A1 E2F3 ARID1B CHD4 USP11	9.37e-05	339	47	5	30415952
Pubmed	Mouse model of muscleblind-like 1 overexpression: skeletal muscle effects and therapeutic promise.	MBNL2 MBNL1	9.75e-05	11	47	2	22846424
Pubmed	USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair.	CHD4 USP11	1.17e-04	12	47	2	31504778
Pubmed	Dynamic SUMOylation of MORC2 orchestrates chromatin remodelling and DNA repair in response to DNA damage and drives chemoresistance in breast cancer.	CHD4 TRIM28	1.17e-04	12	47	2	36793866
Pubmed	RBM4 Modulates Radial Migration via Alternative Splicing of Dab1 during Cortex Development.	PTBP1 RBM4B	1.17e-04	12	47	2	29581187
Pubmed	Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1.	MBNL2 MBNL1	1.17e-04	12	47	2	37143315
Pubmed	Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters.	DDX20 PTBP1 GPX1	1.29e-04	72	47	3	36012204
Pubmed	SOX2 hypomorphism disrupts development of the prechordal floor and optic cup.	TBX3 OTX1	1.38e-04	13	47	2	22522080
Pubmed	The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain.	CHD4 TRIM28	1.38e-04	13	47	2	15882967
Pubmed	Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function.	POU3F3 OTX1	1.38e-04	13	47	2	18596172
Pubmed	Genetic control of brain morphogenesis through Otx gene dosage requirement.	OTP OTX1	1.38e-04	13	47	2	9342056
Pubmed	Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.	CHD4 INCENP TRIM28	1.40e-04	74	47	3	29795351
Pubmed	The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer.	POU3F3 OTP POU6F2	1.46e-04	75	47	3	37298722
Pubmed	Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions.	MBNL2 MBNL1	1.61e-04	14	47	2	28826478
Pubmed	Decoding neuronal composition and ontogeny of individual hypothalamic nuclei.	TBX3 OTP	1.86e-04	15	47	2	33600763
Pubmed	Muscleblind-like 1 is required for normal heart valve development in vivo.	MBNL2 MBNL1	1.86e-04	15	47	2	26472242
Pubmed	DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex.	POU3F3 TLE4	1.86e-04	15	47	2	25556833
Pubmed	TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77.	CHD4 TRIM28	1.86e-04	15	47	2	19321449
Pubmed	Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy.	MBNL2 MBNL1	2.12e-04	16	47	2	16717059
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	CHD4 TRIM28 AMOT MAZ KIF7	2.29e-04	411	47	5	35182466
Pubmed	Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling.	E2F3 MBNL2 TRIM28	2.58e-04	91	47	3	21194568
Pubmed	TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation.	CHD4 TRIM28	2.70e-04	18	47	2	28068325
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	ARID1B CHD4 TRIM28 USP11 AMOT	3.14e-04	440	47	5	34244565
Interaction	ZNF34 interactions	TBX3 POU6F2 OTX1 TRIM28	5.09e-06	49	47	4	int:ZNF34
Interaction	VAX2 interactions	GTF2A1 POU6F2 GPX1	5.30e-06	15	47	3	int:VAX2
Cytoband	13q32.1	DZIP1 MBNL2	1.22e-04	16	47	2	13q32.1
Cytoband	Xq26.3	SMIM10L2A SMIM10L2B	2.17e-03	67	47	2	Xq26.3
GeneFamily	PHD finger proteins	MLLT6 CHD4 TRIM28	7.56e-04	90	36	3	88
GeneFamily	POU class homeoboxes and pseudogenes	POU3F3 POU6F2	9.50e-04	23	36	2	523
GeneFamily	Zinc fingers CCCH-type	MBNL2 MBNL1	2.20e-03	35	36	2	73
Disease	myotonic disease (implicated_via_orthology)	MBNL2 MBNL1	6.82e-06	3	45	2	DOID:450 (implicated_via_orthology)
Disease	myotonic dystrophy type 2 (implicated_via_orthology)	MBNL2 MBNL1	2.27e-05	5	45	2	DOID:0050759 (implicated_via_orthology)
Disease	myotonic dystrophy type 1 (implicated_via_orthology)	MBNL2 MBNL1	3.40e-05	6	45	2	DOID:11722 (implicated_via_orthology)
Disease	lung non-small cell carcinoma (is_implicated_in)	E2F3 ARID1B FOXL2 GPX1	6.05e-05	139	45	4	DOID:3908 (is_implicated_in)
Disease	IGF-1 measurement	TBX3 E2F3 SOWAHA RASA2 TLE4 KIF7	9.36e-05	488	45	6	EFO_0004627
Disease	laryngeal squamous cell carcinoma (is_marker_for)	FOXL2 GPX1	3.83e-04	19	45	2	DOID:2876 (is_marker_for)
Disease	Nephroblastoma	POU6F2 TRIM28	1.39e-03	36	45	2	C0027708
Disease	colorectal cancer (is_marker_for)	TBX3 CHD4 GPX1	1.78e-03	157	45	3	DOID:9256 (is_marker_for)
Disease	Breast adenocarcinoma	TBX3 ARID1B	1.80e-03	41	45	2	C0858252
Disease	Neoplasm of uncertain or unknown behavior of breast	TBX3 ARID1B	1.80e-03	41	45	2	C0496956
Disease	C-reactive protein measurement	ONECUT2 SP9 DDX20 PTBP1 ACADS TLE4 MBNL1	2.18e-03	1206	45	7	EFO_0004458
Disease	sitting height ratio	ARID1B CABLES1	2.77e-03	51	45	2	EFO_0007118

Protein segments in the cluster

Peptide	Gene	Start	Entry
TSLMAAAAAAAAVAA	MLLT6	1036	P55198
TMVAAAPVAVAAAAA	AMOT	906	Q4VCS5
AMAKLAASEAATAIS	ACADS	346	P16219
MASPALAAALAVAAA	ADRA2C	1	P18825
MCAARLAAAAAAAQS	GPX1	1	P07203
MAARAAAAAAAAAAR	ARID1B	1	Q8NFD5
MAAAFEASGALAAVA	DDX20	1	Q9UHI6
MAAATAAAALAAADP	SLC25A16	1	P16260
MAAAAPAAAAASSEA	RASA2	1	Q15283
AAAAAAAAAAATYHM	NKX2-4	81	Q9H2Z4
ARAAARAHTAAMANA	MAGEB18	316	Q96M61
RAAAAAAAATMALAA	INCENP	126	Q9NQS7
MASMAAAIAASRSAV	C1orf198	1	Q9H425
ASCQMAAAAAAAAAA	FOXL2	216	P58012
AAAAAASRSAMVTSM	ONECUT2	96	O95948
TASAAAAMRLGAECA	KIF7	396	Q2M1P5
VCPMAAAAAAAAAAA	MAZ	431	P56270
MAATAVAAAVAGTES	GGA2	1	Q9UJY4
AAATSAAMAAAAATT	RBM4B	281	Q9BQ04
MQRSVAAGAATAAAS	OTX1	206	P32242
MAASEAAAAAGSAAL	ATMIN	1	O43313
GAAVVAAAAAASMDK	E2F3	21	O00716
AAAAAASMDKRALLA	E2F3	26	O00716
MAAAAAAATTAACSS	CABLES1	1	Q8TDN4
ATKMAAIATDTAAAG	C16orf96	601	A6NNT2
QAAAAQAAATAAAMT	MBNL1	256	Q9NR56
VAAQAAAAAATVMAF	MBNL2	256	Q5VZF2
VAAAAAAAVAVVESM	CHD4	226	Q14839
MGTAAAAAAAAAAAA	NIPA1	1	Q7RTP0
AAAAAAAAAHLPSMA	POU3F3	196	P20264
SAAAAAAAAMGDSLC	OTP	186	Q5XKR4
QPATAAAAAAAAAAM	SOX3	351	P41225
MAAVAAEAAATAASP	PWWP2A	1	Q96N64
LDSTAMASAAAAQGL	TBX3	556	O15119
TYMAAAAAASSAAAS	TBX3	606	O15119
LASQAAAAAAAMSSI	POU6F2	301	P78424
AAAAAAMSSIASSQA	POU6F2	306	P78424
MAASAALSAAAAAAA	SMIM10L2A	1	P0DMW4
MAASAALSAAAAAAA	SMIM10L2B	1	P0DMW5
VAVAAAAAGAASMAC	DZIP1	31	Q86YF9
SAAVAAAAASAMISG	SP9	271	P0CG40
AAAASAMISGAAAAA	SP9	276	P0CG40
MAAAAAAAAAVGVRL	CNNM1	1	Q9NRU3
ASNMSAAATAATLAL	GTF2A1	131	P52655
MALAAAAAAAAAGVS	SOWAHA	1	Q2M3V2
PQMSAAAAAAAAAAA	TLE4	401	Q04727
MAAAAAATAAAAASI	SCFD1	1	Q8WVM8
MAATPSARAAAAVVA	TRUB1	31	Q8WWH5
NLALAASAAAVDAGM	PTBP1	161	P26599
RTAMATVAANPAAAA	USP11	41	P51784
MAASAAAASAAAASA	TRIM28	1	Q13263