Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	dynein intermediate chain binding	DNAH12 DNAH17 DNAH2 DYNLT2	3.94e-06	37	58	4	GO:0045505
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH12 DNAH17 DNAH2	1.84e-05	18	58	3	GO:0008569
GeneOntologyMolecularFunction	glycerol kinase activity	GK GK2	2.48e-05	3	58	2	GO:0004370
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH12 DNAH17 DNAH2	7.24e-05	28	58	3	GO:0051959
GeneOntologyBiologicalProcess	glycerol-3-phosphate biosynthetic process	GK GK2	2.25e-05	3	57	2	GO:0046167
GeneOntologyBiologicalProcess	regulation of phosphatase activity	MAGI2 HSP90B2P RIPK3 VCAN	5.22e-05	74	57	4	GO:0010921
GeneOntologyCellularComponent	dynein complex	DNAH12 DNAH17 DNAH2 DYNLT2	1.63e-05	54	59	4	GO:0030286
GeneOntologyCellularComponent	axonemal dynein complex	DNAH12 DNAH17 DNAH2	4.70e-05	25	59	3	GO:0005858
GeneOntologyCellularComponent	microtubule associated complex	DNAH12 DNAH17 DNAH2 BIRC5 DYNLT2	9.11e-05	161	59	5	GO:0005875
GeneOntologyCellularComponent	inner dynein arm	DNAH12 DNAH2	3.47e-04	10	59	2	GO:0036156
Domain	Carb_kinase_FGGY_CS	GK GK2	2.74e-05	3	57	2	IPR018483
Domain	Glycerol_kin	GK GK2	5.47e-05	4	57	2	IPR005999
Domain	FGGY_KINASES_2	GK GK2	9.10e-05	5	57	2	PS00445
Domain	FGGY_KINASES_1	GK GK2	9.10e-05	5	57	2	PS00933
Domain	Carb_kinase_FGGY_C	GK GK2	9.10e-05	5	57	2	IPR018485
Domain	FGGY_C	GK GK2	1.36e-04	6	57	2	PF02782
Domain	Carb_kinase_FGGY_N	GK GK2	1.36e-04	6	57	2	IPR018484
Domain	Carb_kinase_FGGY	GK GK2	1.90e-04	7	57	2	IPR000577
Domain	FGGY_N	GK GK2	1.90e-04	7	57	2	PF00370
Domain	Dynein_heavy_chain_D4_dom	DNAH12 DNAH2	8.13e-04	14	57	2	IPR024317
Domain	Dynein_heavy_dom-2	DNAH12 DNAH2	8.13e-04	14	57	2	IPR013602
Domain	DHC_N2	DNAH12 DNAH2	8.13e-04	14	57	2	PF08393
Domain	AAA_8	DNAH12 DNAH2	8.13e-04	14	57	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH12 DNAH2	8.13e-04	14	57	2	IPR011704
Domain	AAA_5	DNAH12 DNAH2	8.13e-04	14	57	2	PF07728
Domain	DHC_fam	DNAH12 DNAH2	9.37e-04	15	57	2	IPR026983
Domain	Dynein_heavy_dom	DNAH12 DNAH2	9.37e-04	15	57	2	IPR004273
Domain	Dynein_heavy	DNAH12 DNAH2	9.37e-04	15	57	2	PF03028
Domain	Nucleotide-bd_a/b_plait	SRRT LARP6 SCAF8 EIF3B NOL8	1.13e-03	258	57	5	IPR012677
Domain	-	HIVEP2 ZSCAN10 ZNF334 ZNF37A ZNF81 ZNF510 ZNF782	4.44e-03	679	57	7	3.30.160.60
Domain	KRAB	ZNF334 ZNF37A ZNF81 ZNF510 ZNF782	4.66e-03	358	57	5	PS50805
Domain	KRAB	ZNF334 ZNF37A ZNF81 ZNF510 ZNF782	4.66e-03	358	57	5	PF01352
Domain	zf-C2H2	HIVEP2 ZSCAN10 ZNF334 ZNF37A ZNF81 ZNF510 ZNF782	4.96e-03	693	57	7	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	HIVEP2 ZSCAN10 ZNF334 ZNF37A ZNF81 ZNF510 ZNF782	5.00e-03	694	57	7	IPR013087
Domain	KRAB	ZNF334 ZNF37A ZNF81 ZNF510 ZNF782	5.29e-03	369	57	5	SM00349
Domain	KRAB	ZNF334 ZNF37A ZNF81 ZNF510 ZNF782	5.35e-03	370	57	5	IPR001909
Domain	-	LARP6 SCAF8 EIF3B NOL8	6.53e-03	244	57	4	3.30.70.330
Domain	ZINC_FINGER_C2H2_2	HIVEP2 ZSCAN10 ZNF334 ZNF37A ZNF81 ZNF510 ZNF782	8.98e-03	775	57	7	PS50157
Domain	ZINC_FINGER_C2H2_1	HIVEP2 ZSCAN10 ZNF334 ZNF37A ZNF81 ZNF510 ZNF782	9.10e-03	777	57	7	PS00028
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH12 DNAH17 DNAH2	9.00e-05	27	46	3	M47755
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH12 DNAH17 DNAH2	1.84e-06	14	61	3	9373155
Pubmed	Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci.	ZNF510 ZNF782	3.03e-06	2	61	2	19030899
Pubmed	Notch2 signaling sensitizes endothelial cells to apoptosis by negatively regulating the key protective molecule survivin.	BIRC5 NOTCH2	3.03e-06	2	61	2	20011512
Pubmed	Glycerol kinase 2 is essential for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during mouse spermatogenesis.	GK GK2	3.03e-06	2	61	2	30662012
Pubmed	Glycerol kinase-like proteins cooperate with Pld6 in regulating sperm mitochondrial sheath formation and male fertility.	GK GK2	9.07e-06	3	61	2	28852571
Pubmed	The tyrosine kinase receptor RET interacts in vivo with aryl hydrocarbon receptor-interacting protein to alter survivin availability.	BIRC5 RET	9.07e-06	3	61	2	19366855
Pubmed	Activation of Wnt signaling reduces ipsilaterally projecting retinal ganglion cells in pigmented retina.	VCAN RTN2 NOTCH2	2.23e-05	31	61	3	30254141
Pubmed	The glycerol kinase gene family: structure of the Xp gene, and related intronless retroposons.	GK GK2	3.02e-05	5	61	2	7987308
Pubmed	DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.	RIPK3 KRR1	3.02e-05	5	61	2	19590578
Pubmed	Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb.	HSP90B2P VCAN BIRC5	3.52e-05	36	61	3	22421546
Pubmed	Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.	DNAH12 DNAH2	6.32e-05	7	61	2	9256245
Pubmed	Retrotransposition of glycerol kinase-related genes from the X chromosome to autosomes: functional and evolutionary aspects.	GK GK2	6.32e-05	7	61	2	10444329
Pubmed	Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.	DNAH17 DNAH2	6.32e-05	7	61	2	31178125
Pubmed	The small-subunit processome is a ribosome assembly intermediate.	UTP18 KRR1	8.42e-05	8	61	2	15590835
Pubmed	Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes.	MAGI2 PRICKLE1	1.08e-04	9	61	2	20534871
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	NRIP1 DNAH12 PRICKLE1 RRP7BP UBR4 DNAH2 PRRC2B	1.25e-04	638	61	7	31182584
Pubmed	The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells.	PRPF31 SRRT	1.97e-04	12	61	2	23793891
Pubmed	Identification of novel genes expressed during metanephric induction through single-cell library screening.	ANAPC2 RET	1.97e-04	12	61	2	10844592
Pubmed	Spatial gene expression in the T-stage mouse metanephros.	VCAN RET	1.97e-04	12	61	2	16545622
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	PRPF31 NRIP1 DNAH12 P4HA1 CT47A1 OBSCN	2.36e-04	497	61	6	36774506
Pubmed	Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma.	SRRT POLR3D SCAF8 PRRC2B PHC2	2.83e-04	329	61	5	34316702
Pubmed	Requirement of Math1 for secretory cell lineage commitment in the mouse intestine.	GAST NOTCH2	3.57e-04	16	61	2	11739954
Pubmed	The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled.	PRICKLE1 RET	3.57e-04	16	61	2	22771245
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	PRPF31 UTP18 HIVEP2 EIF3B KRR1 MOB4 USP20 PRRC2B	3.59e-04	1005	61	8	19615732
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	LARP6 SCAF8 EIF3B KRR1 NOL8	3.62e-04	347	61	5	16033648
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	PSME3IP1 P4HA1 STXBP5 EIF3B SMAP2 NOTCH2 PRRC2B PHC2	3.64e-04	1007	61	8	34597346
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	MAGI2 NRIP1 HIVEP2 LARP6 ZNF334 UBR4 NAP1L2 UBASH3A MVP	3.84e-04	1285	61	9	35914814
Pubmed	Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.	UBR4 ANAPC2	4.05e-04	17	61	2	29033132
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	PRPF31 SRRT UBR4 EIF3B KRR1 PRRC2B	4.08e-04	551	61	6	34728620
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	PRPF31 NRIP1 UTP18 P4HA1 SCAF8 UBR4 EIF3B KRR1 NOTCH2	4.61e-04	1318	61	9	30463901
Pubmed	T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration.	PRICKLE1 RET	6.22e-04	21	61	2	17119020
Pubmed	Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis.	PRICKLE1 RET	6.83e-04	22	61	2	27582005
Pubmed	Targeted disruption of the histone lysine 79 methyltransferase Dot1L in nephron progenitors causes congenital renal dysplasia.	RET NOTCH2	7.48e-04	23	61	2	33315499
Pubmed	Comparative analysis of 1196 orthologous mouse and human full-length mRNA and protein sequences.	GK RET	8.84e-04	25	61	2	8889551
Pubmed	Phosphoproteomic analysis of the developing mouse brain.	SRRT EIF3B SMAP2 RTN2	9.29e-04	246	61	4	15345747
Pubmed	A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice.	VCAN NOTCH2	1.03e-03	27	61	2	29956664
Pubmed	YAP and TAZ are required for the postnatal development and the maintenance of the structural integrity of the oviduct.	BIRC5 NOTCH2	1.19e-03	29	61	2	32520726
Pubmed	HERC2 Facilitates BLM and WRN Helicase Complex Interaction with RPA to Suppress G-Quadruplex DNA.	EIF3B USP20	1.36e-03	31	61	2	30279242
Pubmed	Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.	PRPF31 POLR3D UTP18 P4HA1 BIRC5 KRR1	1.45e-03	704	61	6	32994395
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	SRRT HSP90B2P SCAF8 UBR4 PRRC2B	1.48e-03	475	61	5	31040226
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	PRPF31 SRRT UTP18 EIF3B KRR1 MVP PHC2 NOL8	1.53e-03	1257	61	8	36526897
Pubmed	A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.	SRRT EIF3B MVP PRRC2B	1.62e-03	286	61	4	32041737
Pubmed	A human MAP kinase interactome.	RALGDS HIVEP2 CPLANE1 FAM13B MOB4	1.63e-03	486	61	5	20936779
Pubmed	A genome-wide association study (GWAS) for bronchopulmonary dysplasia.	MAGI2 STXBP5	1.64e-03	34	61	2	23897914
Pubmed	Control of endodermal endocrine development by Hes-1.	GAST NOTCH2	1.64e-03	34	61	2	10615124
Cytoband	7q21	MAGI2 SRRT	1.34e-04	13	61	2	7q21
Cytoband	9q22.33	ZNF510 ZNF782	8.93e-04	33	61	2	9q22.33
Cytoband	Ensembl 112 genes in cytogenetic band chr9q34	RALGDS ANAPC2 USP20 PRRC2B	9.36e-04	325	61	4	chr9q34
Cytoband	Ensembl 112 genes in cytogenetic band chr9q22	ZNF510 ZNF782 NOL8	2.43e-03	200	61	3	chr9q22
Cytoband	1p34.3	SMIM12 PHC2	3.12e-03	62	61	2	1p34.3
Cytoband	19q13.32	PPP1R37 RTN2	4.41e-03	74	61	2	19q13.32
Cytoband	Ensembl 112 genes in cytogenetic band chr6q24	HIVEP2 STXBP5	4.89e-03	78	61	2	chr6q24
GeneFamily	Dyneins, axonemal	DNAH12 DNAH17 DNAH2	5.71e-06	17	38	3	536
GeneFamily	Glycerol kinases	GK GK2	6.42e-05	6	38	2	568
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	HIVEP2 ZSCAN10 ZNF334 ZNF37A ZNF81 ZNF510 ZNF782	6.51e-04	718	38	7	28
GeneFamily	RNA binding motif containing	SCAF8 EIF3B NOL8	1.00e-02	213	38	3	725
GeneFamily	WD repeat domain containing	UTP18 STXBP5 WDR87	1.75e-02	262	38	3	362
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC6A6 NRIP1 GK P4HA1 VCAN PHC2	1.62e-07	184	59	6	e343dd7777a29048e3f12a939f7f782b8b7b4fea
Drug	Hydralazine hydrochloride [304-20-1]; Up 200; 20.4uM; HL60; HT_HG-U133A	RALGDS HIVEP2 VCAN OAS2 ZNF510 RET NOTCH2	8.85e-07	198	60	7	2349_UP
Drug	adenosine-5'-trimetaphosphate	GK GK2 OAS2	2.83e-06	11	60	3	CID000193895
Drug	2-phosphoglycerate	GK GK2 VCAN GAST UBASH3A	4.92e-06	94	60	5	CID000000059
Disease	glycerol kinase deficiency (implicated_via_orthology)	GK GK2	1.10e-05	3	57	2	DOID:0060363 (implicated_via_orthology)
Disease	gastroesophageal reflux disease	NRIP1 HIVEP2 VCAN	9.96e-04	101	57	3	EFO_0003948
Disease	revision of total knee arthroplasty	SLC6A6 MAGI2	1.16e-03	26	57	2	EFO_0020972
Disease	retinitis pigmentosa (implicated_via_orthology)	SLC6A6 PRPF31	1.25e-03	27	57	2	DOID:10584 (implicated_via_orthology)
Disease	cervical cancer	BIRC5 NOTCH2	1.98e-03	34	57	2	C4048328
Disease	Uterine Cervical Neoplasm	BIRC5 NOTCH2	2.09e-03	35	57	2	C0007873
Disease	daytime rest measurement	HIVEP2 SCAF8 KRR1 SUCO	2.55e-03	295	57	4	EFO_0007828
Disease	factor VIII measurement	RALGDS STXBP5	2.73e-03	40	57	2	EFO_0004630
Disease	bronchopulmonary dysplasia	MAGI2 STXBP5	3.44e-03	45	57	2	MONDO_0019091

Protein segments in the cluster

Peptide	Gene	Start	Entry
FKELEGWEPDDDPIE	BIRC5	61	O15392
SDEWDIPEKQPFKDL	EIF3B	276	P55884
WPPFKDEKLEVPEDI	ANAPC2	601	Q9UJX6
TQEEFPWKEQTAEKP	VCAN	1031	P13611
PKVESPEEIQWFADK	CLYBL	136	Q8N0X4
NKEEEDPKGIPDFWL	NAP1L2	231	Q9ULW6
PEEVTKSQPEKWDEE	CT47A1	246	Q5JQC4
EHWVDDEGPQPKKVK	NOTCH2	1756	Q04721
EKEFEPLPNWVKDKA	HSP90B2P	251	Q58FF3
KENELPYGWEKIDDP	MAGI2	346	Q86UL8
EFPREGWVEQDPKEI	GK3P	46	Q14409
KNVSDGDKWEEPFPA	FAM13B	471	Q9NYF5
KDDENPVPDSVGKWE	DNAH12	1806	Q6ZR08
WDPKVPDVDIKEDQD	NRIP1	471	P48552
LEQEWKPPDEELIKK	LARP6	81	Q9BRS8
VPDGWKEPAFSKEDN	KRR1	36	Q13601
EEGTPWNEDCGKEKP	NOL8	1011	Q76FK4
KEEELEVSFEPPKWK	OAS2	446	P29728
DEVLWEKELPPGVEE	MVP	411	Q14764
DEDIVSGAVEPKDPW	PPP1R37	51	O75864
KPLEDQWVAPGEDVE	OBSCN	2831	Q5VST9
FILAPAKQEDEWDKP	P4HA1	321	P13674
EFWKGRVEQETPEDP	PRICKLE1	391	Q96MT3
DPSKKQGPWLEEEEE	GAST	71	P01350
EFPKEGWVEQDPKEI	GK2	46	Q14410
VNIWEPIEEEKPDEA	CPLANE1	1431	Q9H799
SEAPEKEIFPKEWKN	DNAH17	3806	Q9UFH2
EFPREGWVEQDPKEI	GK	46	P32189
FVPESPDGQEKKFWE	RALGDS	726	Q12967
DEKPDEKWILFDGPV	DNAH2	2156	Q9P225
IPWEKVKVDDLEGFA	SCAF8	571	Q9UPN6
LEEEEKQWGPLEREP	RTN2	236	O75298
PQKKPVWVDEEDEDE	UTP18	136	Q9Y5J1
GWLFKEENDEPDVKP	POLR3D	186	P05423
EDEAEGKPPQREKWS	SLC6A6	31	P31641
KILEPPEGQDEGVWK	MOB4	56	Q9Y3A3
EWEKVRKPEDPEECP	PSME3IP1	31	Q9GZU8
EPWREHNVPEEKDEK	STXBP5	876	Q5T5C0
PKEEEWEKPKDAAGL	SRRT	396	Q9BXP5
EKGEEPWILEEKFPS	ZNF37A	61	P17032
KEEEGVPDEEGWVKV	RRP7BP	16	Q9NSQ0
QCVPDDWKEVAPGEK	PHC2	466	Q8IXK0
KEEFKQEEPKGAAWP	ZSCAN10	216	Q96SZ4
PDVIFKLEQGEEPWI	ZNF334	56	Q9HCZ1
EGVIEKVNWDQDPKP	RIPK3	76	Q9Y572
EKDDKWKRGSEPVPE	SMAP2	136	Q8WU79
KDEIERKFDKWQEPP	PRPF31	321	Q8WWY3
EEEEKPDKAWEARPP	PRRC2B	1021	Q5JSZ5
SPKDPEDIPTFDEWK	SUCO	261	Q9UBS9
REWEAFVKGKDNEPP	USP20	826	Q9Y2K6
LEWFIRGKDPQPVEE	SMIM12	31	Q96EX1
VDAFKILEDPKWEFP	RET	706	P07949
WPYKVATEEKPEAEE	nan	211	Q3C1V9
KPEVIFKLEQGEEPW	ZNF510	91	Q9Y2H8
EQGEDPWLLEKEKGF	ZNF782	61	Q6ZMW2
AQSKEPEKPVEEFQW	HIVEP2	906	P31629
PKEKWVESAFEVDGP	UBR4	5021	Q5T4S7
LLEDLDWDVVPPEKK	WDR87	1301	Q6ZQQ6
KPEVIFKLEQGEGPW	ZNF81	66	P51508
EENKEEGKWELVNPP	UBASH3A	626	P57075
LWPPEKLQEIEEFKE	PET100	41	P0DJ07
PPFDDSIADIGKEWK	DYNLT2	61	Q8IZS6
KKKDDDDLGIPPEIW	MYBPC2	201	Q14324