Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	RCC1	RCBTB1 RPGR	2.59e-03	20	71	2	PF00415
Domain	RCC1_1	RCBTB1 RPGR	2.86e-03	21	71	2	PS00625
Domain	RCC1_2	RCBTB1 RPGR	2.86e-03	21	71	2	PS00626
Domain	RCC1_3	RCBTB1 RPGR	2.86e-03	21	71	2	PS50012
Domain	Reg_chr_condens	RCBTB1 RPGR	3.13e-03	22	71	2	IPR000408
Domain	Beta_defensin	DEFB127 DEFB129	3.13e-03	22	71	2	IPR025933
Domain	Defensin_beta_2	DEFB127 DEFB129	3.13e-03	22	71	2	PF13841
Domain	-	RCBTB1 RPGR	3.13e-03	22	71	2	2.130.10.30
Domain	CT	GREM2 CCN6	3.13e-03	22	71	2	SM00041
Domain	-	DBF4B TOPBP1	3.42e-03	23	71	2	3.40.50.10190
Domain	RCC1/BLIP-II	RCBTB1 RPGR	3.42e-03	23	71	2	IPR009091
Domain	Cys_knot_C	GREM2 CCN6	4.04e-03	25	71	2	IPR006207
Domain	CTCK_2	GREM2 CCN6	4.04e-03	25	71	2	PS01225
Pubmed	TopBP1 assembles nuclear condensates to switch on ATR signaling.	ATR TOPBP1	4.59e-06	2	75	2	33503405
Pubmed	TopBP1 and ATR colocalization at meiotic chromosomes: role of TopBP1/Cut5 in the meiotic recombination checkpoint.	ATR TOPBP1	4.59e-06	2	75	2	14718568
Pubmed	High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation.	ATR TOPBP1	4.59e-06	2	75	2	25916852
Pubmed	Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation.	ATR TOPBP1	4.59e-06	2	75	2	20566845
Pubmed	An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.	ATR TOPBP1	1.37e-05	3	75	2	23950734
Pubmed	RBMX is required for activation of ATR on repetitive DNAs to maintain genome stability.	ATR TOPBP1	1.37e-05	3	75	2	32494026
Pubmed	Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to Chemotherapy by Abrogating the TopBP1/ATR-Mediated DNA Damage Response.	ATR TOPBP1	1.37e-05	3	75	2	31533931
Pubmed	Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells.	ATR TOPBP1	1.37e-05	3	75	2	23226797
Pubmed	ATR activation is regulated by dimerization of ATR activating proteins.	ATR TOPBP1	1.37e-05	3	75	2	33636182
Pubmed	TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.	ATR TOPBP1	1.37e-05	3	75	2	18519640
Pubmed	STAT-5 Regulates Transcription of the Topoisomerase IIβ-Binding Protein 1 (TopBP1) Gene To Activate the ATR Pathway and Promote Human Papillomavirus Replication.	ATR TOPBP1	1.37e-05	3	75	2	26695634
Pubmed	Coupling of Homologous Recombination and the Checkpoint by ATR.	ATR PALB2	1.37e-05	3	75	2	28089683
Pubmed	Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation.	ATR TOPBP1	1.37e-05	3	75	2	31913317
Pubmed	TopBP1 activates the ATR-ATRIP complex.	ATR TOPBP1	1.37e-05	3	75	2	16530042
Pubmed	ATR autophosphorylation as a molecular switch for checkpoint activation.	ATR TOPBP1	1.37e-05	3	75	2	21777809
Pubmed	Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancer.	ATR TOPBP1	1.37e-05	3	75	2	33556369
Pubmed	Exploring the link between MORF4L1 and risk of breast cancer.	ATR TOPBP1 PALB2	1.89e-05	24	75	3	21466675
Pubmed	Direct role for the replication protein treslin (Ticrr) in the ATR kinase-mediated checkpoint response.	ATR TOPBP1	2.75e-05	4	75	2	23696651
Pubmed	Phosphorylation of the BRCA1 C terminus (BRCT) repeat inhibitor of hTERT (BRIT1) protein coordinates TopBP1 protein recruitment and amplifies ataxia telangiectasia-mutated and Rad3-related (ATR) Signaling.	ATR TOPBP1	2.75e-05	4	75	2	25301947
Pubmed	Phosphorylation of ATR-interacting protein on Ser239 mediates an interaction with breast-ovarian cancer susceptibility 1 and checkpoint function.	ATR TOPBP1	2.75e-05	4	75	2	17616665
Pubmed	Common motifs in ETAA1 and TOPBP1 required for ATR kinase activation.	ATR TOPBP1	2.75e-05	4	75	2	30940728
Pubmed	Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.	ATR TOPBP1	2.75e-05	4	75	2	17686975
Pubmed	The Ddc2/ATRIP checkpoint protein monitors meiotic recombination intermediates.	ATR TOPBP1	2.75e-05	4	75	2	21693576
Pubmed	Akt switches TopBP1 function from checkpoint activation to transcriptional regulation through phosphoserine binding-mediated oligomerization.	ATR TOPBP1	2.75e-05	4	75	2	24081328
Pubmed	HCLK2 is required for activity of the DNA damage response kinase ATR.	ATR TOPBP1	2.75e-05	4	75	2	19097996
Pubmed	Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation.	ATR TOPBP1	2.75e-05	4	75	2	16880517
Pubmed	Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.	ATR TOPBP1 PALB2	4.15e-05	31	75	3	19690177
Pubmed	Mammalian Emi2 mediates cytostatic arrest and transduces the signal for meiotic exit via Cdc20.	FBXO5 FBXO43	4.57e-05	5	75	2	16456547
Pubmed	Genome Protection by the 9-1-1 Complex Subunit HUS1 Requires Clamp Formation, DNA Contacts, and ATR Signaling-independent Effector Functions.	ATR TOPBP1	4.57e-05	5	75	2	25911100
Pubmed	Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.	ATR TOPBP1	4.57e-05	5	75	2	28439015
Pubmed	Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1).	ATR TOPBP1	4.57e-05	5	75	2	21502314
Pubmed	Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis.	DEFB127 DEFB129	6.84e-05	6	75	2	12620395
Pubmed	Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway.	ATR TOPBP1	9.57e-05	7	75	2	20029092
Pubmed	Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms.	ATR TOPBP1	9.57e-05	7	75	2	22549958
Pubmed	BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade.	ATR TOPBP1	1.64e-04	9	75	2	23901102
Pubmed	Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk.	ATR PALB2	2.04e-04	10	75	2	37592023
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ATR ITSN1 SVIL ZNF638 RERE BCOR PHF10 PALB2	2.63e-04	774	75	8	15302935
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	RLF BBX NMNAT1 TOPBP1 BRD1 BCOR MBD4	3.42e-04	608	75	7	36089195
Pubmed	A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.	ATR TOPBP1	3.52e-04	13	75	2	21659603
Pubmed	The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception.	TRPA1 CASP1	3.52e-04	13	75	2	30240621
Pubmed	Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.	RERE MUCL3 PALB2	3.82e-04	65	75	3	23453885
Pubmed	An investigation into the human serum "interactome".	RLF TGM4 SACS PALB2	4.26e-04	162	75	4	15174051
Pubmed	The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features.	ATR PALB2	4.73e-04	15	75	2	19536649
Pubmed	The DNA sequence and analysis of human chromosome 13.	SACS RCBTB1 CCDC168 ZMYM5	5.11e-04	170	75	4	15057823
Pubmed	Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.	ATR TOPBP1	5.40e-04	16	75	2	27760317
Pubmed	An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse.	RLF BRD1	6.87e-04	18	75	2	24025402
Pubmed	Does 3D Phenotyping Yield Substantial Insights in the Genetics of the Mouse Mandible Shape?	ATR RERE	6.87e-04	18	75	2	26921296
Pubmed	Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1.	FBXO5 PALB2	6.87e-04	18	75	2	31257023
Pubmed	Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice.	FBXO5 GAS2	7.66e-04	19	75	2	15799026
Pubmed	Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.	ATR TOPBP1	7.66e-04	19	75	2	21478856
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	CCDC137 NMNAT1 SVIL ZNF638 BRD1	7.69e-04	332	75	5	25693804
Pubmed	Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.	ZNF142 CELSR2 TOPBP1	7.82e-04	83	75	3	9039502
Pubmed	Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span.	IGF2R ATR	1.33e-03	25	75	2	23563309
Pubmed	ATR maintains select progenitors during nervous system development.	ATR TOPBP1	1.33e-03	25	75	2	22266795
Pubmed	Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer.	ATR MBD4	1.44e-03	26	75	2	20731661
Pubmed	SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination.	ATR TOPBP1	1.56e-03	27	75	2	25703348
Pubmed	Mammalian SWI/SNF collaborates with a polycomb-associated protein to regulate male germline transcription in the mouse.	ATR PHF10	1.92e-03	30	75	2	31043422
Pubmed	Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications.	CASP1 CXCL1	1.92e-03	30	75	2	28096401
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	BBX CCDC137 ATR NMNAT1 PHF10	1.95e-03	410	75	5	26949251
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	RLF RERE BCOR PALB2 ZMYM5	2.12e-03	418	75	5	34709266
Disease	Adenoid Cystic Carcinoma	GAS2 BRD1 BCOR CMTR2	1.01e-04	100	71	4	C0010606
Disease	total blood protein measurement	FRK BBX TTC41P RCBTB1 ZNF638 USP4 CXCL1	1.04e-04	449	71	7	EFO_0004536
Disease	Osteosarcoma	CYP3A4 EXT2 BCOR	2.01e-04	47	71	3	C0029463
Disease	Bronchial Hyperreactivity	TRPA1 CXCL1	3.71e-04	12	71	2	C0085129
Disease	Retinal Degeneration	NMNAT1 RPGR	1.16e-03	21	71	2	C0035304
Disease	attention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia	RERE MUCL3 PALB2	1.88e-03	101	71	3	EFO_0003756, EFO_0003761, EFO_0003888, MONDO_0004985, MONDO_0005090
Disease	neurotic disorder	BBX RERE GRM8	1.88e-03	101	71	3	EFO_0004257
Disease	Cone-Rod Dystrophy 2	NMNAT1 RPGR	2.22e-03	29	71	2	C3489532
Disease	Age related macular degeneration	NMNAT1 RPGR	2.38e-03	30	71	2	C0242383

Protein segments in the cluster

Peptide	Gene	Start	Entry
PQQKICKKPNLVVKP	TDRD5	416	Q8NAT2
PGLRSKEKKKVNCKP	CCDC137	41	Q6PK04
KKAKKALAEPCAVLP	BRD1	431	O95696
SLKFRPKGKTCPKEI	ERVK-18	106	O42043
LLKPTCGRKVSLPNK	ANKRD30B	616	Q9BXX2
KCVPVPRKKKKTGNV	BBX	711	Q8WY36
HKLGCCVVEKPQPKK	CDC42SE1	6	Q9NRR8
GRKACLNPASPIVKK	CXCL1	81	P09341
CSVPLKKGKDAPIKK	APTX	161	Q7Z2E3
ILEGKKLPKVKCSPF	CMTR2	496	Q8IYT2
PQKKLECLKEPGKTS	CABYR	76	O75952
VLKKVGCKALVFPKQ	ACSF2	166	Q96CM8
SAQPHKGILKKKCLP	CELSR2	2831	Q9HCU4
KRQLPVFAKICSKPK	C1orf94	311	Q6P1W5
KPSGKRLCKTKHLIP	BCOR	1356	Q6W2J9
LYKAIKAGIKCKPPL	ARMC12	31	Q5T9G4
STLVPKKLEGLCGKK	RCBTB1	61	Q8NDN9
PAKRTCKQKPVSKVV	FMN1	316	Q68DA7
IKKLFCLQKVLNKPG	OR6K3	316	Q8NGY3
PVAKTGLKLTFCPKK	FNDC7	696	Q5VTL7
QCKQVLLPPKKLSKT	LRRC53	741	A6NM62
CKSPGYKPIKKIQLQ	CFAP52	276	Q8N1V2
KPCKETQIPLKLSLG	CYP3A4	466	P08684
LLCTPIKNGKKNKVI	PDE5A	451	O76074
RQKTSLKKACPGVVP	PGLYRP4	201	Q96LB8
NIKELEACKKITKPP	DEFB127	56	Q9H1M4
DPPFRLKKIQKVKQC	GREM2	141	Q9H772
CSLPCKPGERKKTVK	GRM8	516	O00222
KPGERKKTVKGVPCC	GRM8	521	O00222
ARAPVKPKEKKKGPC	MEIOSIN	521	C9JSJ3
VPGVPGVCRKTKKKH	DTX1	371	Q86Y01
PLKLEKVKSCSEKPV	PALB2	621	Q86YC2
KPKVIPNAICGICLK	PHF10	371	Q8WUB8
SPTQKKKCILPRKEK	FBXO43	121	Q4G163
ILKTIKIPKGKTCQP	CCN6	256	O95389
CVKLGKPCLKIQVPA	FRK	201	P42685
ITAKNKKPSGLCPKC	ERVK-5	571	Q9HDB9
SVCKPFLFLLKKKIP	ATR	761	Q13535
KKGCKVTLPEKPVKL	FBF1	6	Q8TES7
NTKNCPSLKDKPKVI	CASP1	266	P29466
KASCKIGPLPGTKKS	FBXO5	426	Q9UKT4
KKCCVGPKVVKLIKN	DEFB129	51	Q9H1M3
LASLCVKKQQPKKPE	DBF4B	196	Q8NFT6
KKDQGSKGPVTKCLL	ITSN1	1686	Q15811
TILKGIPIKKTKKGC	MBD4	236	O95243
KLAKPPTICKIVGKD	ENO4	61	A6NNW6
KLKICSLKPKQPGHS	HCAR1	291	Q9BXC0
TLVNPKCGIIKAKKP	CCDC168	1701	Q8NDH2
GKKFCPLAQAVIKPI	SACS	1281	Q9NZJ4
KKTICTKGKNTPVPE	MUCL3	316	Q3MIW9
LPLKKQPHRTCKKVS	PRR14L	1516	Q5THK1
EKVKCILKTPGKINC	RHOBTB3	376	O94955
SKPTCVKALKPEKVK	RPGR	76	Q92834
VKALKPEKVKLAACG	RPGR	81	Q92834
KPTKNLPLKKIPCKT	GAS2	86	O43903
KKIKTNITLVCKPGD	IGF2R	576	P11717
RKKISGPNPLSCLKK	UTP23	196	Q9BRU9
GPNPLSCLKKKKKAP	UTP23	201	Q9BRU9
HQPKKPITLKRPICK	SPDYA	26	Q5MJ70
KKYLVKLKSINPPCV	SOS2	911	Q07890
GKIPKCSLLQPKEVL	SVIL	1581	O95425
PQKIKLAQKSEIPKC	FYB2	76	Q5VWT5
PKAKAPQKSQKTLGC	SPATA31E1	1186	Q6ZUB1
KCTPIKTGPKKFIVK	TGM4	651	P49221
QRLVKKPVPKLIEKC	RERE	381	Q9P2R6
ETTQKKIKGQPCPKR	USP4	691	Q13107
LQILLKKGAKPCKSN	TRPA1	181	O75762
KKKLLLKGSQKGICP	RLF	616	Q13129
KAVIKVTPRKKFKCP	EXT2	641	Q93063
SKCAPGKGKKKPIIC	TTC41P	1176	Q6P2S7
GKGKKKPIICISAEE	TTC41P	1181	Q6P2S7
CKQLPSPQSLKGKIL	PLCH1	426	Q4KWH8
VKNKPVLLVCKAVPA	UNC5A	56	Q6ZN44
LTKPAKITCANCKKP	ZMYM5	236	Q9UJ78
CDVKPKVTGLTVPLK	TTC16	46	Q8NEE8
LKKCPVLLRKNKGLP	ZNF142	886	P52746
APKPLHKVVVCVSKK	TOPBP1	901	Q92547
PLTIKGKSVKICVPG	ZNF638	736	Q14966
GKSVKICVPGKKKAQ	ZNF638	741	Q14966
LEPKTKAVPKVKLLC	NMNAT1	141	Q9HAN9