Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein tyrosine kinase activity	ERBB4 ABL2 NRP2 EFNA4 FGFR3 FGFR2 MERTK MAP2K3	1.50e-06	145	111	8	GO:0004713
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	ERBB4 NRP2 EFNA4 FGFR3 FGFR2 MERTK	1.63e-06	65	111	6	GO:0004714
GeneOntologyMolecularFunction	kinase activity	ERBB4 SLK ABL2 MAP4K3 PI4KAP2 NRP2 PRKD3 FCSK PASK EFNA4 FGFR3 FGFR2 MERTK MAP2K3 MAP4K2 MAP3K19	4.95e-06	764	111	16	GO:0016301
GeneOntologyMolecularFunction	protein kinase activity	ERBB4 SLK ABL2 MAP4K3 NRP2 PRKD3 PASK EFNA4 FGFR3 FGFR2 MERTK MAP2K3 MAP4K2 MAP3K19	6.06e-06	600	111	14	GO:0004672
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	ERBB4 NRP2 EFNA4 FGFR3 FGFR2 MERTK	7.88e-06	85	111	6	GO:0019199
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	ERBB4 SLK ABL2 MAP4K3 NRP2 PRKD3 FCSK PASK EFNA4 FGFR3 FGFR2 MERTK MAP2K3 MAP4K2 MAP3K19	8.92e-06	709	111	15	GO:0016773
GeneOntologyMolecularFunction	hydrolase activity, acting on glycosyl bonds	MGAM ACER1 ACER3 GLB1L KL GLB1 SMPD1	1.59e-05	144	111	7	GO:0016798
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing O-glycosyl compounds	MGAM ACER1 ACER3 GLB1L KL GLB1	2.38e-05	103	111	6	GO:0004553
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	ERBB4 SLK ABL2 MAP4K3 PI4KAP2 NRP2 PRKD3 FCSK PASK EFNA4 FGFR3 FGFR2 MERTK MAP2K3 MAP4K2 MAP3K19	6.10e-05	938	111	16	GO:0016772
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine phosphatase activity	PTPRU PTPRK PTPRM	1.07e-04	17	111	3	GO:0005001
GeneOntologyMolecularFunction	transmembrane receptor protein phosphatase activity	PTPRU PTPRK PTPRM	1.07e-04	17	111	3	GO:0019198
GeneOntologyMolecularFunction	growth factor binding	ERBB4 NRP2 KL WFIKKN1 FGFR3 FGFR2	2.38e-04	156	111	6	GO:0019838
GeneOntologyMolecularFunction	beta-galactosidase activity	GLB1L GLB1	3.03e-04	5	111	2	GO:0004565
GeneOntologyMolecularFunction	fibroblast growth factor receptor activity	FGFR3 FGFR2	3.03e-04	5	111	2	GO:0005007
GeneOntologyMolecularFunction	fibroblast growth factor binding	KL FGFR3 FGFR2	4.44e-04	27	111	3	GO:0017134
GeneOntologyMolecularFunction	MAP kinase kinase kinase kinase activity	MAP4K3 MAP4K2	4.53e-04	6	111	2	GO:0008349
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ATP8B3 ABCA1 ABCA12	4.95e-04	28	111	3	GO:0140326
GeneOntologyMolecularFunction	N-acylsphingosine amidohydrolase activity	ACER1 ACER3	6.32e-04	7	111	2	GO:0017040
GeneOntologyMolecularFunction	galactosidase activity	GLB1L GLB1	6.32e-04	7	111	2	GO:0015925
GeneOntologyMolecularFunction	G protein-coupled opioid receptor activity	SIGMAR1 OPRL1	6.32e-04	7	111	2	GO:0004985
GeneOntologyMolecularFunction	phosphatidylserine floppase activity	ATP8B3 ABCA1	1.07e-03	9	111	2	GO:0090556
GeneOntologyMolecularFunction	acyltransferase activity	UBR2 TRAF3 ITCH WWP2 HECTD4 HGSNAT RNF149 KAT2B UBE2G2 GLUL CERS1 EPB42	1.26e-03	775	111	12	GO:0016746
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	ACHE SGSH WRN PTPN22 PTPRU PDE10A ARSA PTPRK PTPRM LIPH SMPD1 GNAS	1.77e-03	807	111	12	GO:0016788
GeneOntologyMolecularFunction	cyclin-dependent protein serine/threonine kinase inhibitor activity	CDKN1C KAT2B	1.95e-03	12	111	2	GO:0004861
GeneOntologyBiologicalProcess	sphingolipid metabolic process	ACER1 ACER3 ABCA12 DEGS1 PRKD3 GLB1 SMPD1 CERS1	4.37e-06	176	109	8	GO:0006665
GeneOntologyBiologicalProcess	heparan sulfate proteoglycan catabolic process	SGSH HGSNAT GLB1	1.18e-05	9	109	3	GO:0030200
GeneOntologyBiologicalProcess	proteoglycan catabolic process	SGSH HGSNAT GLB1	2.30e-05	11	109	3	GO:0030167
GeneOntologyBiologicalProcess	membrane lipid metabolic process	ACER1 ACER3 ABCA12 DEGS1 PRKD3 GLB1 SMPD1 CERS1	2.96e-05	229	109	8	GO:0006643
GeneOntologyBiologicalProcess	ceramide metabolic process	ACER1 ACER3 ABCA12 DEGS1 SMPD1 CERS1	3.03e-05	113	109	6	GO:0006672
GeneOntologyBiologicalProcess	sphingolipid biosynthetic process	ACER1 ACER3 DEGS1 PRKD3 SMPD1 CERS1	3.69e-05	117	109	6	GO:0030148
GeneOntologyBiologicalProcess	protein K63-linked ubiquitination	UBR2 TRAF3 ITCH WWP2 PTPN22	5.15e-05	76	109	5	GO:0070534
GeneOntologyBiologicalProcess	fibroblast growth factor receptor apoptotic signaling pathway	FGFR3 FGFR2	8.27e-05	3	109	2	GO:1902178
GeneOntologyBiologicalProcess	sphingolipid catabolic process	ACER1 ACER3 GLB1 SMPD1	1.30e-04	49	109	4	GO:0030149
GeneOntologyCellularComponent	lysosomal lumen	SGSH HGSNAT ARSA GLB1 SMPD1	1.55e-04	98	108	5	GO:0043202
HumanPheno	Chorea	SIGMAR1 PTPN22 PDE10A MECP2 ARSA SUOX TRPM3 SLC13A5 GNAS CERS1 FOXG1	6.78e-06	248	45	11	HP:0002072
MousePheno	respiratory distress	CDKN1C ABCA1 MECP2 KL SMPD1 FGFR3 FGFR2 GNAS FOXG1	8.40e-06	204	93	9	MP:0001954
MousePheno	Purkinje cell degeneration	ACER3 KL ARSA GLB1 SMPD1 CERS1	1.60e-05	81	93	6	MP:0000876
MousePheno	abnormal ceramide level	ACER1 ACER3 DEGS1 SMPD1	5.72e-05	32	93	4	MP:0012232
MousePheno	abnormal sterol level	MBTPS1 ABCA1 TAGAP ABCA12 ATG2B WRN PDE10A MECP2 PRKD3 KAT2B CRYGS KL MIA2 CTAGE1 SMPD1 WDR41 GNAS	6.07e-05	880	93	17	MP:0012224
MousePheno	abnormal hindlimb morphology	TBX15 SGSH HGSNAT APLP2 SLC5A1 PRKD3 KL WFIKKN1 OGFOD1 SLC13A5 FGFR3 FGFR2 GNAS	1.08e-04	576	93	13	MP:0000556
MousePheno	tremors	ITCH ACHE MECP2 SHISA7 DEGS1 ARSA GLB1 SMPD1 GNAS CERS1	1.17e-04	353	93	10	MP:0000745
MousePheno	abnormal cholesterol homeostasis	MBTPS1 ABCA1 TAGAP ABCA12 ATG2B WRN HGSNAT PDE10A MECP2 PRKD3 KAT2B CRYGS MIA2 CTAGE1 SMPD1 WDR41 GNAS	1.29e-04	936	93	17	MP:0005278
MousePheno	abnormal sphingolipid level	ACER1 ACER3 DEGS1 SMPD1	1.40e-04	40	93	4	MP:0012230
MousePheno	long incisors	WWP2 FGFR3 FGFR2	1.50e-04	16	93	3	MP:0004831
MousePheno	macrodontia	WWP2 FGFR3 FGFR2	1.50e-04	16	93	3	MP:0030091
MousePheno	abnormal cerebellar cortex morphology	ACER3 HGSNAT MECP2 KL ARSA GLB1 SMPD1 GNAS CERS1	1.70e-04	300	93	9	MP:0004097
MousePheno	abnormal cholesterol level	MBTPS1 ABCA1 TAGAP ABCA12 ATG2B WRN PDE10A MECP2 PRKD3 KAT2B CRYGS MIA2 CTAGE1 SMPD1 WDR41 GNAS	1.75e-04	867	93	16	MP:0003947
MousePheno	vagina atresia	CDKN1C AR MERTK	1.81e-04	17	93	3	MP:0001144
MousePheno	abnormal breathing pattern	CDKN1C ABCA1 MECP2 KL SMPD1 FGFR3 FGFR2 GNAS FOXG1	1.83e-04	303	93	9	MP:0001951
MousePheno	abnormal acromion morphology	TBX15 FGFR2	2.60e-04	4	93	2	MP:0004345
MousePheno	decreased Sertoli cell phagocytosis	ARSA MERTK	2.60e-04	4	93	2	MP:0009853
MousePheno	abnormal respiratory function	CDKN1C ABCA1 ACHE MECP2 KL SMPD1 FGFR3 FGFR2 GNAS FOXG1	3.14e-04	399	93	10	MP:0002327
MousePheno	abnormal circulating cholesterol level	MBTPS1 ABCA1 TAGAP ATG2B WRN PDE10A MECP2 PRKD3 KAT2B CRYGS MIA2 CTAGE1 SMPD1 WDR41 GNAS	3.27e-04	823	93	15	MP:0000180
Domain	Galactose-bd-like	GLB1L PTPRU NRP2 NDUFAF1 GLB1 PTPRK PTPRM	1.20e-06	94	108	7	IPR008979
Domain	Protein_kinase_ATP_BS	ERBB4 SLK ABL2 MAP4K3 PRKD3 PASK FGFR3 FGFR2 MERTK MAP2K3 MAP4K2 MAP3K19	1.98e-06	379	108	12	IPR017441
Domain	MAM	PTPRU NRP2 PTPRK PTPRM	2.37e-06	17	108	4	SM00137
Domain	MAM	PTPRU NRP2 PTPRK PTPRM	3.04e-06	18	108	4	PF00629
Domain	MAM_dom	PTPRU NRP2 PTPRK PTPRM	3.04e-06	18	108	4	IPR000998
Domain	MAM_2	PTPRU NRP2 PTPRK PTPRM	3.04e-06	18	108	4	PS50060
Domain	PROTEIN_KINASE_ATP	ERBB4 SLK ABL2 MAP4K3 PRKD3 PASK FGFR3 FGFR2 MERTK MAP2K3 MAP4K2 MAP3K19	1.39e-05	459	108	12	PS00107
Domain	Prot_kinase_dom	ERBB4 SLK ABL2 MAP4K3 PRKD3 PASK FGFR3 FGFR2 MERTK MAP2K3 MAP4K2 MAP3K19	2.59e-05	489	108	12	IPR000719
Domain	PROTEIN_KINASE_DOM	ERBB4 SLK ABL2 MAP4K3 PRKD3 PASK FGFR3 FGFR2 MERTK MAP2K3 MAP4K2 MAP3K19	2.81e-05	493	108	12	PS50011
Domain	SNO	SBNO2 SBNO1	3.31e-05	2	108	2	IPR026741
Domain	SBNO_Helicase_C_dom	SBNO2 SBNO1	3.31e-05	2	108	2	IPR026937
Domain	ST7	ST7 ST7L	3.31e-05	2	108	2	PF04184
Domain	Helicase_C_4	SBNO2 SBNO1	3.31e-05	2	108	2	PF13871
Domain	ST7	ST7 ST7L	3.31e-05	2	108	2	IPR007311
Domain	PTPc	PTPN22 PTPRU PTPRK PTPRM	5.40e-05	36	108	4	SM00194
Domain	Kinase-like_dom	ERBB4 SLK ABL2 MAP4K3 PRKD3 PASK FGFR3 FGFR2 MERTK MAP2K3 MAP4K2 MAP3K19	7.01e-05	542	108	12	IPR011009
Domain	TYR_PHOSPHATASE_PTP	PTPN22 PTPRU PTPRK PTPRM	7.44e-05	39	108	4	PS50055
Domain	PTPase_domain	PTPN22 PTPRU PTPRK PTPRM	9.08e-05	41	108	4	IPR000242
Domain	Y_phosphatase	PTPN22 PTPRU PTPRK PTPRM	9.08e-05	41	108	4	PF00102
Domain	Ceramidase	ACER1 ACER3	9.90e-05	3	108	2	PF05875
Domain	Ceramidase	ACER1 ACER3	9.90e-05	3	108	2	IPR008901
Domain	MAM_1	PTPRU PTPRK PTPRM	9.97e-05	16	108	3	PS00740
Domain	Tyr_kinase_cat_dom	ERBB4 ABL2 FGFR3 FGFR2 MERTK	1.58e-04	88	108	5	IPR020635
Domain	TyrKc	ERBB4 ABL2 FGFR3 FGFR2 MERTK	1.58e-04	88	108	5	SM00219
Domain	IG	PTPRU PTPRK PTPRM WFIKKN1 BTN1A1 FGFR3 FGFR2 MERTK MOG ADGRA3	1.65e-04	421	108	10	SM00409
Domain	Ig_sub	PTPRU PTPRK PTPRM WFIKKN1 BTN1A1 FGFR3 FGFR2 MERTK MOG ADGRA3	1.65e-04	421	108	10	IPR003599
Domain	Glyco_hydro_35	GLB1L GLB1	1.97e-04	4	108	2	PF01301
Domain	GLYCOSYL_HYDROL_F35	GLB1L GLB1	1.97e-04	4	108	2	PS01182
Domain	MAPKKKK	MAP4K3 MAP4K2	1.97e-04	4	108	2	IPR021160
Domain	Gly_Hdrlase_35_cat	GLB1L GLB1	1.97e-04	4	108	2	IPR031330
Domain	Glycoside_Hdrlase_35	GLB1L GLB1	1.97e-04	4	108	2	IPR001944
Domain	FGF_rcpt_fam	FGFR3 FGFR2	1.97e-04	4	108	2	IPR016248
Domain	B-gal_1-like	GLB1L GLB1	1.97e-04	4	108	2	IPR026283
Domain	PROTEIN_KINASE_TYR	ERBB4 ABL2 FGFR3 FGFR2 MERTK	2.49e-04	97	108	5	PS00109
Domain	Tyr_kinase_AS	ERBB4 ABL2 FGFR3 FGFR2 MERTK	2.49e-04	97	108	5	IPR008266
Domain	Glycoside_hydrolase_SF	MGAM GLB1L KL GLB1	2.49e-04	53	108	4	IPR017853
Domain	PTPc_motif	PTPN22 PTPRU PTPRK PTPRM	3.77e-04	59	108	4	SM00404
Domain	Tyr_Pase_cat	PTPN22 PTPRU PTPRK PTPRM	3.77e-04	59	108	4	IPR003595
Domain	IG_LIKE	PTPRU PTPRK PTPRM WFIKKN1 BTN1A1 FGFR3 FGFR2 MERTK MOG ADGRA3	5.58e-04	491	108	10	PS50835
Domain	Ig-like_dom	PTPRU PTPRK PTPRM WFIKKN1 BTN1A1 FGFR3 FGFR2 MERTK MOG ADGRA3	6.72e-04	503	108	10	IPR007110
Domain	Ig_I-set	PTPRK WFIKKN1 FGFR3 FGFR2 MERTK ADGRA3	8.30e-04	190	108	6	IPR013098
Domain	I-set	PTPRK WFIKKN1 FGFR3 FGFR2 MERTK ADGRA3	8.30e-04	190	108	6	PF07679
Domain	Tyr_Pase_AS	PTPN22 PTPRU PTPRK PTPRM	8.47e-04	73	108	4	IPR016130
Domain	Pkinase_Tyr	ERBB4 ABL2 FGFR3 FGFR2 MERTK	9.18e-04	129	108	5	PF07714
Domain	-	GLB1L KL GLB1	1.08e-03	35	108	3	3.20.20.80
Domain	Ser-Thr/Tyr_kinase_cat_dom	ERBB4 ABL2 FGFR3 FGFR2 MERTK	1.24e-03	138	108	5	IPR001245
Domain	Glyco_hydro_catalytic_dom	GLB1L KL GLB1	1.37e-03	38	108	3	IPR013781
Domain	TYR_PHOSPHATASE_1	PTPN22 PTPRU PTPRK PTPRM	1.56e-03	86	108	4	PS00383
Domain	-	PTPRU PTPRK PTPRM WFIKKN1 BTN1A1 FGFR3 FGFR2 MERTK MOG ADGRA3 EPB42	1.58e-03	663	108	11	2.60.40.10
Domain	TYR_PHOSPHATASE_dom	PTPN22 PTPRU PTPRK PTPRM	1.63e-03	87	108	4	IPR000387
Domain	TYR_PHOSPHATASE_2	PTPN22 PTPRU PTPRK PTPRM	1.63e-03	87	108	4	PS50056
Domain	-	PTPN22 PTPRU PTPRK PTPRM	2.00e-03	92	108	4	3.90.190.10
Domain	ABC_A	ABCA1 ABCA12	2.11e-03	12	108	2	IPR026082
Domain	Ig-like_fold	PTPRU PTPRK PTPRM WFIKKN1 BTN1A1 FGFR3 FGFR2 MERTK MOG ADGRA3 EPB42	2.58e-03	706	108	11	IPR013783
Domain	Prot-tyrosine_phosphatase-like	PTPN22 PTPRU PTPRK PTPRM	2.61e-03	99	108	4	IPR029021
Domain	CNH	MAP4K3 MAP4K2	2.88e-03	14	108	2	SM00036
Domain	CNH	MAP4K3 MAP4K2	3.31e-03	15	108	2	PF00780
Domain	CNH	MAP4K3 MAP4K2	3.31e-03	15	108	2	PS50219
Domain	CNH_dom	MAP4K3 MAP4K2	3.31e-03	15	108	2	IPR001180
Domain	Sulfatase_CS	SGSH ARSA	3.77e-03	16	108	2	IPR024607
Domain	SULFATASE_1	SGSH ARSA	4.26e-03	17	108	2	PS00523
Domain	SULFATASE_2	SGSH ARSA	4.26e-03	17	108	2	PS00149
Domain	Ser/Thr_kinase_AS	SLK MAP4K3 PRKD3 PASK MAP2K3 MAP4K2 MAP3K19	4.71e-03	357	108	7	IPR008271
Domain	Sulfatase	SGSH ARSA	4.77e-03	18	108	2	PF00884
Domain	KU	APLP2 WFIKKN1	4.77e-03	18	108	2	SM00131
Domain	Sulfatase_N	SGSH ARSA	4.77e-03	18	108	2	IPR000917
Domain	-	APLP2 WFIKKN1	4.77e-03	18	108	2	4.10.410.10
Domain	Prtase_inh_Kunz-CS	APLP2 WFIKKN1	4.77e-03	18	108	2	IPR020901
Domain	S_TKc	SLK MAP4K3 PRKD3 PASK MAP2K3 MAP4K2 MAP3K19	4.86e-03	359	108	7	SM00220
Domain	ig	PTPRK PTPRM FGFR3 MERTK ADGRA3	4.95e-03	190	108	5	PF00047
Domain	Immunoglobulin	PTPRK PTPRM FGFR3 MERTK ADGRA3	4.95e-03	190	108	5	IPR013151
Domain	PROTEIN_KINASE_ST	SLK MAP4K3 PRKD3 PASK MAP2K3 MAP4K2 MAP3K19	5.08e-03	362	108	7	PS00108
Domain	BPTI_KUNITZ_1	APLP2 WFIKKN1	5.31e-03	19	108	2	PS00280
Domain	BPTI_KUNITZ_2	APLP2 WFIKKN1	5.31e-03	19	108	2	PS50279
Domain	Kunitz_BPTI	APLP2 WFIKKN1	5.31e-03	19	108	2	PF00014
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	ACER1 ACER3 GLB1L DEGS1 PRKD3 ARSA GLB1 SMPD1 CERS1	1.52e-08	107	85	9	M14857
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	ACER1 ACER3 GLB1L DEGS1 ARSA GLB1 SMPD1 CERS1	7.71e-08	92	85	8	MM15086
Pathway	KEGG_SPHINGOLIPID_METABOLISM	ACER1 ACER3 DEGS1 ARSA GLB1 SMPD1	1.12e-07	39	85	6	M15955
Pathway	REACTOME_HS_GAG_DEGRADATION	SGSH GLB1L HGSNAT GLB1	9.99e-06	23	85	4	MM14804
Pathway	REACTOME_HS_GAG_DEGRADATION	SGSH GLB1L HGSNAT GLB1	1.19e-05	24	85	4	M636
Pathway	REACTOME_MUCOPOLYSACCHARIDOSES	SGSH HGSNAT GLB1	3.37e-05	11	85	3	M27160
Pathway	REACTOME_GLYCOSPHINGOLIPID_CATABOLISM	GLB1L ARSA GLB1 SMPD1	4.97e-05	34	85	4	MM17076
Pathway	REACTOME_GLYCOSPHINGOLIPID_CATABOLISM	GLB1L ARSA GLB1 SMPD1	8.62e-05	39	85	4	M48042
Pathway	WP_GLYCOSAMINOGLYCAN_DEGRADATION	SGSH HGSNAT GLB1	1.35e-04	17	85	3	M39832
Pathway	PID_TNF_PATHWAY	MAP4K3 SMPD1 MAP2K3 MAP4K2	1.66e-04	46	85	4	M128
Pathway	KEGG_GLYCOSAMINOGLYCAN_DEGRADATION	SGSH HGSNAT GLB1	2.60e-04	21	85	3	M3624
Pathway	REACTOME_GLYCOSPHINGOLIPID_METABOLISM	GLB1L ARSA GLB1 SMPD1	2.88e-04	53	85	4	MM14647
Pathway	REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM	SGSH GLB1L HGSNAT GLB1	3.09e-04	54	85	4	MM14633
Pathway	WP_FGF23_SIGNALING_IN_HYPOPHOSPHATEMIC_RICKETS_AND_RELATED_DISORDERS	KL FGFR3 FGFR2	3.43e-04	23	85	3	M39862
Pathway	REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM	SGSH GLB1L HGSNAT GLB1	3.81e-04	57	85	4	M692
Pathway	REACTOME_GLYCOSPHINGOLIPID_METABOLISM	GLB1L ARSA GLB1 SMPD1	4.08e-04	58	85	4	M576
Pathway	WP_SPHINGOLIPID_METABOLISM_OVERVIEW	DEGS1 SMPD1 CERS1	4.42e-04	25	85	3	MM15931
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_UBIQUITINATION_OF_RTK_BY_CBL	ERBB4 FGFR3 FGFR2	4.42e-04	25	85	3	M47934
Pathway	WP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY	DEGS1 SMPD1 CERS1	4.98e-04	26	85	3	M39784
Pathway	WP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY	DEGS1 SMPD1 CERS1	4.98e-04	26	85	3	MM15892
Pathway	WP_SPHINGOLIPID_METABOLISM_OVERVIEW	DEGS1 SMPD1 CERS1	5.57e-04	27	85	3	M39863
Pathway	REACTOME_METABOLISM_OF_LIPIDS	MBTPS1 ABCA1 ACER1 ACER3 ACHE GLB1L DEGS1 PRKD3 ARSA GLB1 LIPH SMPD1 CERS1	5.71e-04	757	85	13	M27451
Pathway	KEGG_MEDICUS_REFERENCE_HEPARAN_SULFATE_DEGRADATION	SGSH HGSNAT	7.40e-04	7	85	2	M47608
Pathway	KEGG_LYSOSOME	SGSH HGSNAT ARSA GLB1 SMPD1	8.14e-04	121	85	5	M11266
Pathway	KEGG_MEDICUS_REFERENCE_HYDROLYSIS_OF_SPHINGOMYELIN	ACER1 SMPD1	9.83e-04	8	85	2	M47611
Pathway	REACTOME_DISEASES_OF_CARBOHYDRATE_METABOLISM	SGSH HGSNAT GLB1	1.11e-03	34	85	3	M27546
Pathway	REACTOME_CREB3_FACTORS_ACTIVATE_GENES	MBTPS1 DCSTAMP	1.26e-03	9	85	2	M27773
Pathway	REACTOME_DOWNREGULATION_OF_ERBB4_SIGNALING	ERBB4 ITCH	1.26e-03	9	85	2	M26930
Pathway	REACTOME_DOWNREGULATION_OF_ERBB4_SIGNALING	ERBB4 ITCH	1.26e-03	9	85	2	MM14535
Pubmed	Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.	ACER1 ACER3 DEGS1 SMPD1 CERS1	2.31e-08	27	111	5	23096701
Pubmed	Differential expression of MAM-subfamily protein tyrosine phosphatases during mouse development.	PTPRU PTPRK PTPRM	1.26e-07	4	111	3	9510027
Pubmed	Persistent fibroblast growth factor 23 signalling in the parathyroid glands for secondary hyperparathyroidism in mice with chronic kidney disease.	KL FGFR3 FGFR2	3.15e-07	5	111	3	28094278
Pubmed	RUNX3 suppresses metastasis and stemness by inhibiting Hedgehog signaling in colorectal cancer.	ITCH KAT2B SUFU	6.28e-07	6	111	3	31278361
Pubmed	Regulation of fibroblast growth factor-23 signaling by klotho.	KL FGFR3 FGFR2	6.28e-07	6	111	3	16436388
Pubmed	Central role of the proximal tubular αKlotho/FGF receptor complex in FGF23-regulated phosphate and vitamin D metabolism.	KL FGFR3 FGFR2	6.28e-07	6	111	3	29720668
Pubmed	Fibroblast growth factor signaling regulates Dach1 expression during skeletal development.	CDKN1C FGFR3 FGFR2	1.10e-06	7	111	3	12203718
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	UBR2 MBTPS1 SIGMAR1 SGSH RNF149 APLP2 DEGS1 NRP2 MEST ARSA MIA2 GLB1 PTPRK SMPD1 CERS1 ADGRA3	1.39e-06	1201	111	16	35696571
Pubmed	Fibroblast growth factor signaling is required for the generation of oligodendrocyte progenitors from the embryonic forebrain.	FGFR3 FGFR2 FOXG1	5.12e-06	11	111	3	21451043
Pubmed	Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.	ERBB4 FGFR3 FGFR2 MERTK	8.22e-06	40	111	4	30898150
Pubmed	Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways.	ERBB4 ITCH WWP2	8.84e-06	13	111	3	20858735
Pubmed	Activation of FGF receptors by mutations in the transmembrane domain.	FGFR3 FGFR2	1.01e-05	2	111	2	9136983
Pubmed	The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation.	ERBB4 ITCH	1.01e-05	2	111	2	17463226
Pubmed	Prognostic impact of FGFR2/3 alterations in patients with biliary tract cancers receiving systemic chemotherapy: the BITCOIN study.	FGFR3 FGFR2	1.01e-05	2	111	2	35303508
Pubmed	Loads, capacities and safety factors of maltase and the glucose transporter SGLT1 in mouse intestinal brush border.	MGAM SLC5A1	1.01e-05	2	111	2	12122147
Pubmed	Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression.	FGFR3 FGFR2	1.01e-05	2	111	2	21152424
Pubmed	Phenotype Differentiation of FOXG1 and MECP2 Disorders: A New Method for Characterization of Developmental Encephalopathies.	MECP2 FOXG1	1.01e-05	2	111	2	27640358
Pubmed	Germline mutations in FGF receptors and medulloblastomas.	FGFR3 FGFR2	1.01e-05	2	111	2	23325524
Pubmed	Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms.	ERBB4 ITCH	1.01e-05	2	111	2	18334649
Pubmed	Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma.	FGFR3 FGFR2	1.01e-05	2	111	2	23786770
Pubmed	Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer.	SIGMAR1 AR	1.01e-05	2	111	2	28235766
Pubmed	Fibroblast growth factor receptor 3 is a negative regulator of bone growth.	FGFR3 FGFR2	1.01e-05	2	111	2	8601314
Pubmed	Molecular cloning and characterization of mouse St7r (St7-like, St7l).	ST7 ST7L	1.01e-05	2	111	2	12060862
Pubmed	Study of Strawberry Notch homolog 1 and 2 expression in human glioblastoma.	SBNO2 SBNO1	1.01e-05	2	111	2	36695974
Pubmed	Novel targetable FGFR2 and FGFR3 alterations in glioblastoma associate with aggressive phenotype and distinct gene expression programs.	FGFR3 FGFR2	1.01e-05	2	111	2	33853673
Pubmed	ST7-mediated suppression of tumorigenicity of prostate cancer cells is characterized by remodeling of the extracellular matrix.	ST7 ST7L	1.01e-05	2	111	2	16474848
Pubmed	Early mandibular morphological differences in patients with FGFR2 and FGFR3-related syndromic craniosynostoses: A 3D comparative study.	FGFR3 FGFR2	1.01e-05	2	111	2	32822871
Pubmed	Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains.	PTPRK PTPRM	1.01e-05	2	111	2	36436563
Pubmed	Isoform-specific toxicity of Mecp2 in postmitotic neurons: suppression of neurotoxicity by FoxG1.	MECP2 FOXG1	1.01e-05	2	111	2	22357867
Pubmed	Testosterone increases renal anti-aging klotho gene expression via the androgen receptor-mediated pathway.	AR KL	1.01e-05	2	111	2	25163025
Pubmed	Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers.	FGFR3 FGFR2	1.01e-05	2	111	2	11325814
Pubmed	Inhibition of androgen receptor enhanced the anticancer effects of everolimus through targeting glucose transporter 12.	AR SLC2A12	1.01e-05	2	111	2	36594084
Pubmed	Homophilic interactions mediated by receptor tyrosine phosphatases mu and kappa. A critical role for the novel extracellular MAM domain.	PTPRK PTPRM	1.01e-05	2	111	2	7782276
Pubmed	FGF signaling through FGFR1 is required for olfactory bulb morphogenesis.	FGFR3 FGFR2 FOXG1	1.12e-05	14	111	3	12571102
Pubmed	HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity.	ITCH WWP2 SUFU	1.12e-05	14	111	3	26147758
Pubmed	H19 acts as a trans regulator of the imprinted gene network controlling growth in mice.	CDKN1C MEST GNAS	1.40e-05	15	111	3	19762426
Pubmed	Fibroblast growth factor receptor 1 is required for the proliferation of hippocampal progenitor cells and for hippocampal growth in mouse.	FGFR3 FGFR2 FOXG1	1.72e-05	16	111	3	15240797
Pubmed	Elevated fibroblast growth factor 23 exerts its effects on placenta and regulates vitamin D metabolism in pregnancy of Hyp mice.	KL FGFR3 FGFR2	1.72e-05	16	111	3	24470103
Pubmed	Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation.	CDKN1C FGFR3 FGFR2	2.08e-05	17	111	3	18455718
Pubmed	A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo.	FGFR3 FGFR2 FOXG1	2.08e-05	17	111	3	12361972
Pubmed	FGF-Dependent, Context-Driven Role for FRS Adapters in the Early Telencephalon.	FGFR3 FGFR2 FOXG1	2.08e-05	17	111	3	28483978
Pubmed	DOT1L deletion impairs the development of cortical parvalbumin-expressing interneurons.	ERBB4 ACHE NRP2 FOXG1	2.36e-05	52	111	4	37566909
Pubmed	Serological detection of cutaneous T-cell lymphoma-associated antigens.	SLK MIA2 CTAGE1	2.49e-05	18	111	3	11149944
Pubmed	Nolz1 expression is required in dopaminergic axon guidance and striatal innervation.	ERBB4 NRP2 PTPRM FOXG1	2.96e-05	55	111	4	32561725
Pubmed	Transient Redirection of SVZ Stem Cells to Oligodendrogenesis by FGFR3 Activation Promotes Remyelination.	FGFR3 FGFR2	3.02e-05	3	111	2	31189094
Pubmed	[Molecular basis of Rett syndrome: A current look].	MECP2 FOXG1	3.02e-05	3	111	2	26239053
Pubmed	Epilepsy in Rett syndrome: clinical and genetic features.	MECP2 FOXG1	3.02e-05	3	111	2	20728410
Pubmed	In Silico Study of Rett Syndrome Treatment-Related Genes, MECP2, CDKL5, and FOXG1, by Evolutionary Classification and Disordered Region Assessment.	MECP2 FOXG1	3.02e-05	3	111	2	31717404
Pubmed	Isolation of the complementary DNA encoding a mouse heparin-binding growth factor receptor with the use of a unique kinase insert sequence.	FGFR3 FGFR2	3.02e-05	3	111	2	8382556
Pubmed	Cyclin D1 binds the androgen receptor and regulates hormone-dependent signaling in a p300/CBP-associated factor (P/CAF)-dependent manner.	AR KAT2B	3.02e-05	3	111	2	11328859
Pubmed	CircRNA itchy E3 ubiquitin protein ligase improves mitochondrial dysfunction in sepsis-induced acute kidney injury by targeting microRNA-214-3p/ATP-binding cassette A1 axis.	ABCA1 ITCH	3.02e-05	3	111	2	37782276
Pubmed	Fibroblast growth factor receptor signaling in pediatric B-cell precursor acute lymphoblastic leukemia.	FGFR3 FGFR2	3.02e-05	3	111	2	30755670
Pubmed	The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.	TRAF3 PTPN22	3.02e-05	3	111	2	23871208
Pubmed	Androgens transduce the G alphas-mediated activation of protein kinase A in prostate cells.	AR GNAS	3.02e-05	3	111	2	18451148
Pubmed	Differential roles of fibroblast growth factor receptors (FGFR) 1, 2 and 3 in the regulation of S115 breast cancer cell growth.	FGFR3 FGFR2	3.02e-05	3	111	2	23185502
Pubmed	Fibroblast growth factor receptors in in vitro and in vivo chondrogenesis: relating tissue engineering using adult mesenchymal stem cells to embryonic development.	FGFR3 FGFR2	3.02e-05	3	111	2	19728793
Pubmed	Androgen receptor expression in the caput epididymal epithelium is essential for development of the initial segment and epididymal spermatozoa transit.	AR FOXG1	3.02e-05	3	111	2	21177831
Pubmed	Genetic heterogeneity of Saethre-Chotzen syndrome, due to TWIST and FGFR mutations.	FGFR3 FGFR2	3.02e-05	3	111	2	9585583
Pubmed	Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping.	MECP2 FOXG1	3.02e-05	3	111	2	24990380
Pubmed	Oligodendrocytes Support Neuronal Glutamatergic Transmission via Expression of Glutamine Synthetase.	GLUL MOG	3.02e-05	3	111	2	31116973
Pubmed	Epilepsy and genetic in Rett syndrome: A review.	MECP2 FOXG1	3.02e-05	3	111	2	30929312
Pubmed	Mutations in different components of FGF signaling in LADD syndrome.	FGFR3 FGFR2	3.02e-05	3	111	2	16501574
Pubmed	Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases.	ITCH WWP2	3.02e-05	3	111	2	12450395
Pubmed	FGFR Craniosynostosis Syndromes Overview	FGFR3 FGFR2	3.02e-05	3	111	2	20301628
Pubmed	Identification of fibroblast growth factor 9 (FGF9) as a high affinity, heparin dependent ligand for FGF receptors 3 and 2 but not for FGF receptors 1 and 4.	FGFR3 FGFR2	3.02e-05	3	111	2	8619928
Pubmed	Pituitary androgen receptor signalling regulates prolactin but not gonadotrophins in the male mouse.	AR FOXG1	3.02e-05	3	111	2	25799562
Pubmed	Rett Syndrome, a Neurodevelopmental Disorder, Whole-Transcriptome, and Mitochondrial Genome Multiomics Analyses Identify Novel Variations and Disease Pathways.	MECP2 FOXG1	3.02e-05	3	111	2	32105570
Pubmed	Inhibition of endothelial cell Ca²⁺ entry and transient receptor potential channels by Sigma-1 receptor ligands.	SIGMAR1 TRPM3	3.02e-05	3	111	2	23121507
Pubmed	Tubular, lactating, and ductal adenomas are devoid of MED12 Exon2 mutations, and ductal adenomas show recurrent mutations in GNAS and the PI3K-AKT pathway.	FGFR3 GNAS	3.02e-05	3	111	2	27438523
Pubmed	Enrichment of mutations in chromatin regulators in people with Rett syndrome lacking mutations in MECP2.	MECP2 FOXG1	3.02e-05	3	111	2	27171548
Pubmed	Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity.	FGFR3 FGFR2	3.02e-05	3	111	2	14732692
Pubmed	Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway.	FGFR3 FGFR2	3.02e-05	3	111	2	12032146
Pubmed	Fibroblast Growth Factor (FGF-2) and Its Receptors FGFR-2 and FGFR-3 May Be Putative Biomarkers of Malignant Transformation of Potentially Malignant Oral Lesions into Oral Squamous Cell Carcinoma.	FGFR3 FGFR2	3.02e-05	3	111	2	26465941
Pubmed	Expression of fibroblast growth factor receptor1, -2c, and -3c transcripts in mouse molars after tooth eruption.	FGFR3 FGFR2	3.02e-05	3	111	2	33433858
Pubmed	FoxG1, a member of the forkhead family, is a corepressor of the androgen receptor.	AR FOXG1	3.02e-05	3	111	2	17482455
Pubmed	Expression of fibroblast growth factor receptors (FGFR1, FGFR2, FGFR3) in the developing head and face.	FGFR3 FGFR2	3.02e-05	3	111	2	9286594
Pubmed	Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes.	ACER1 ACER3	3.02e-05	3	111	2	20207939
Pubmed	miR-17-5p targets the p300/CBP-associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells.	AR KAT2B	3.02e-05	3	111	2	23095762
Pubmed	Fibroblast growth factor (FGF) 3 from Xenopus laevis (XFGF3) binds with high affinity to FGF receptor 2.	FGFR3 FGFR2	3.02e-05	3	111	2	7896824
Pubmed	Phenotypes in adult patients with Rett syndrome: results of a 13-year experience and insights into healthcare transition.	MECP2 FOXG1	3.02e-05	3	111	2	33106377
Pubmed	FGF-FGFR Mediates the Activity-Dependent Dendritogenesis of Layer IV Neurons during Barrel Formation.	FGFR3 FGFR2	3.02e-05	3	111	2	29097598
Pubmed	Enriched Environment Promotes Adult Hippocampal Neurogenesis through FGFRs.	FGFR3 FGFR2	3.02e-05	3	111	2	33637561
Pubmed	Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner.	ITCH WWP2	3.02e-05	3	111	2	19997087
Pubmed	Fibroblast growth factor receptor (FGFR) gene amplifications are rare events in bladder cancer.	FGFR3 FGFR2	3.02e-05	3	111	2	24898159
Pubmed	FGFR mutations and plagiocephaly.	FGFR3 FGFR2	3.02e-05	3	111	2	18216705
Pubmed	Testosterone regulation on quiescin sulfhydryl oxidase 2 synthesis in the epididymis.	AR FOXG1	3.02e-05	3	111	2	33784244
Pubmed	Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3.	FGFR3 FGFR2	3.02e-05	3	111	2	30202094
Pubmed	The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR.	ITCH WWP2	3.02e-05	3	111	2	29925997
Pubmed	Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes.	FGFR3 FGFR2	3.02e-05	3	111	2	31830366
Pubmed	Tracheal cartilaginous sleeves in children with syndromic craniosynostosis.	FGFR3 FGFR2	3.02e-05	3	111	2	27228464
Pubmed	FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer.	FGFR3 FGFR2	3.02e-05	3	111	2	24850843
Pubmed	The Werner syndrome helicase is a cofactor for HIV-1 long terminal repeat transactivation and retroviral replication.	WRN KAT2B	3.02e-05	3	111	2	17317667
Pubmed	Disruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairment.	FGFR3 FOXG1	3.02e-05	3	111	2	17557302
Pubmed	[Clinical features in Rett syndrome: MECP2-, CDKL5- and FOXG1- related disorders].	MECP2 FOXG1	3.02e-05	3	111	2	24738188
Pubmed	TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development.	TBX15 FGFR3 FGFR2	3.47e-05	20	111	3	36542062
Pubmed	Development of midline cell types and commissural axon tracts requires Fgfr1 in the cerebrum.	FGFR3 FGFR2 FOXG1	3.47e-05	20	111	3	16309667
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	SLK ITCH SIGMAR1 ST7 WWP2 RNF149 DEGS1 NRP2 PASK UBE2G2 SLC16A4 PTPRM ADGRA3	3.50e-05	1061	111	13	33845483
Pubmed	The transcription factor Foxg1 regulates the competence of telencephalic cells to adopt subpallial fates in mice.	MEST FGFR3 FOXG1	4.04e-05	21	111	3	20081193
Pubmed	Phospholipase C-gamma as a signal-transducing element.	KL FGFR3 FGFR2	4.04e-05	21	111	3	10579907
Pubmed	β-Catenin-dependent FGF signaling sustains cell survival in the anterior embryonic head by countering Smad4.	FGFR3 FGFR2 FOXG1	4.04e-05	21	111	3	21571225
Cytoband	3p24-p23	RBMS3 GRIP2	5.79e-06	2	111	2	3p24-p23
Cytoband	18p11.2	PTPRM CTAGE1	2.06e-04	9	111	2	18p11.2
GeneFamily	Alkaline ceramidases	ACER1 ACER3	5.36e-05	3	77	2	400
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	PTPRM WFIKKN1 FGFR3 FGFR2 MERTK ADGRA3	6.39e-05	161	77	6	593
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRU PTPRK PTPRM	9.35e-05	21	77	3	813
GeneFamily	Mitogen-activated protein kinase kinase kinase kinases	MAP4K3 MAP4K2	1.78e-04	5	77	2	655
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	FGFR3 FGFR2 MERTK	6.55e-04	40	77	3	321
GeneFamily	ATP binding cassette subfamily A	ABCA1 ABCA12	1.58e-03	14	77	2	805
GeneFamily	Butyrophilins\|V-set domain containing\|C2-set domain containing	BTN1A1 MOG	1.81e-03	15	77	2	458
GeneFamily	CTAGE family	MIA2 CTAGE1	1.81e-03	15	77	2	907
GeneFamily	Lysine acetyltransferases\|ATAC complex\|SAGA complex\|GCN5 related N-acetyltransferases	KAT2B TAF12	2.34e-03	17	77	2	1059
GeneFamily	Sulfatases	SGSH ARSA	2.62e-03	18	77	2	410
GeneFamily	Fibronectin type III domain containing	PTPRU PTPRK PTPRM MERTK	4.84e-03	160	77	4	555
ToppCell	Control-Epithelial-Club\|Control / Disease state, Lineage and Cell class	ERBB4 PTPRU PTPRK RBMS3 LIPH FGFR3 FGFR2 ADGRA3	2.88e-08	192	111	8	d84ed1ea4a03edaa18c804f75afb03bd7b1f0e16
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ATP8B3 ERBB4 ACHE PTPRM RBMS3 GRIP2 GNAS	2.28e-07	169	111	7	c135d7ae0490d0024e0f4bd8c4ad42f6674a61da
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ABCA1 HECTD4 PTPRK PTPRM CNKSR3 AIG1 SLC13A5	4.20e-07	185	111	7	1d874608aa2062024323512f68889219471b2f00
ToppCell	Control-Epithelial-Club\|World / Disease state, Lineage and Cell class	ERBB4 PTPRK LIPH CNKSR3 FGFR3 FGFR2 ADGRA3	4.36e-07	186	111	7	9798428691408e17ff2af2fe2d1b345f074d67e4
ToppCell	COPD-Epithelial-Club\|World / Disease state, Lineage and Cell class	ERBB4 PTPRK RBMS3 LIPH CNKSR3 FGFR2 ADGRA3	4.36e-07	186	111	7	3006f4ab1eaf1eb34c10ca9f7c869603d2d25744
ToppCell	COPD-Epithelial-Club\|COPD / Disease state, Lineage and Cell class	ERBB4 PTPRK RBMS3 LIPH CNKSR3 FGFR2 ADGRA3	5.21e-07	191	111	7	c909cf5fa0e6519aa93a47d2c3fcd2ae2163cd8d
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D231\|Adult / Lineage, Cell type, age group and donor	ERBB4 NRP2 PTPRK LIPH FGFR2 ADGRA3	4.34e-06	170	111	6	269dee5abca9f6aa079f116f0d8f1d198604d9d4
ToppCell	CD8+_Memory_T_cell-FLU-3\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	ATP8B3 ZCWPW1 ST7 RBSN SLC16A4 PTPRK	4.65e-06	172	111	6	45ac433dbb3796f69e886c04457b2971403050ee
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLK MEST SOX7 PTPRM MOG ZNF367	5.30e-06	176	111	6	269326c2bf44a9003d95bc6dbc839f08f25737ca
ToppCell	COPD-Epithelial-Basal\|COPD / Disease state, Lineage and Cell class	PTPRU PTPRK RBMS3 FGFR3 FGFR2 ADGRA3	6.63e-06	183	111	6	0f760e393edc91009bf6c7e02eeac039a1dfb4ed
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 AR PTPRM RBMS3 GRIP2 FGFR2	7.27e-06	186	111	6	6379609b7ace80683f5754b16aa77f11b43766ae
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CDKN1C ERBB4 GLUL FGFR3 FGFR2 MOG	7.50e-06	187	111	6	97e520705491c8f52a32025311a9fa7b9176979a
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|RV / Chamber and Cluster_Paper	ERBB4 ST7 SLC5A1 AIG1 MICAL3 GRIP2	7.97e-06	189	111	6	9c1debd65c13d63fd4f3158917d621b44b714c26
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KAT2B GLUL FGFR3 FGFR2 MERTK MOG	8.46e-06	191	111	6	f3158cedf67e3b90aa94ea1f61c72c33aaa2d5ba
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2\|World / Primary Cells by Cluster	ERBB4 BRINP1 NRP2 PTPRM RBMS3 GRIP2	9.25e-06	194	111	6	b42fd64b0fb95434a9e4e6586f31d26114a4074b
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2-10\|World / Primary Cells by Cluster	ERBB4 BRINP1 NRP2 PTPRM RBMS3 GRIP2	9.25e-06	194	111	6	81e7bc6516ab8d02ccd1c76a56a3533b788c27c8
ToppCell	10x5'-Lung-Myeloid_Mac-Intermediate_macrophages\|Lung / Manually curated celltypes from each tissue	ABL2 APLP2 NRP2 GLUL MERTK MAP2K3	9.80e-06	196	111	6	fede2c605f7581ce2ea7a284cffffa1a3970d811
ToppCell	Macroglial-Astrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	TRPM3 RBMS3 GLUL FGFR3 MERTK ADGRA3	1.10e-05	200	111	6	941536b7c32f1e63c70535233b2ccce0cd7bf96e
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-CDH12\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CDKN1C ERBB4 PTPRM RBMS3 GLUL GRIP2	1.10e-05	200	111	6	c74bc12e13d002dedaaf75a2244ec111e47524e1
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-mo-Mac\|Myeloid_cells / Location, Cell class and cell subclass	ABCA1 ABL2 NRP2 GLUL GNAS MERTK	1.10e-05	200	111	6	195862a319794e57f0506757ae45ab70200bc5b4
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-CDH12-L1-2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CDKN1C ERBB4 PTPRM RBMS3 GLUL GRIP2	1.10e-05	200	111	6	ead9eb579bb25fde05fc15602e3d05ab6617f7ac
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Interneuron\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	ERBB4 ACHE PTPRM RBMS3 CNKSR3 GLIPR1L2	1.10e-05	200	111	6	a6500d0d2e8bcac92381ab771dbdee66b0e1d48e
ToppCell	(00)_Basal\|World / shred by cell type and Timepoint	ABCA1 RBMS3 GLUL FGFR3 FGFR2	3.60e-05	149	111	5	49e39206f37cee124ca4763c79425b805e50624b
ToppCell	TCGA-Kidney\|World / Sample_Type by Project: Shred V9	MGAM KL CLCN5 SLC16A4 TRPM3	3.84e-05	151	111	5	e31974c0d0a0c644205a0ee6013ab74a09d8a306
ToppCell	10x5'-Liver-Myeloid_Mac-Intestinal_macrophages\|Liver / Manually curated celltypes from each tissue	ABCA1 NRP2 RBMS3 SLC13A5 MERTK	4.48e-05	156	111	5	9a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCell	PND10-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TAGAP PASK SLC16A4 MERTK MAP3K19	5.20e-05	161	111	5	8937f6b92cb2a93ea8c4780d9200a518c3112e53
ToppCell	Frontal_cortex-Neuronal-Inhibitory\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ERBB4 ACHE RBMS3 GRIP2 GNAS	6.55e-05	169	111	5	78eb70dd916724e476eabccf18fb7fcec4210308
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ACHE PTPRU CRYGS PTPRM RBMS3	6.73e-05	170	111	5	8ab67e2b6e30fdf9e9a2c02e31d4df34e751a3ed
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC5A1 EFNA4 RBMS3 FGFR3 FGFR2	6.92e-05	171	111	5	5447b78148f7bccb727e2fc108589b2af02a5d31
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_ductal_cel\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC5A1 EFNA4 RBMS3 FGFR3 FGFR2	7.12e-05	172	111	5	a7eee0a30d2fe20c865a07b9004c6a821a72c0c4
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC5A1 EFNA4 RBMS3 FGFR3 FGFR2	7.12e-05	172	111	5	0a9fe2cd28203970295a1288078c66eadac1c9ed
ToppCell	FLU-Healthy-3\|FLU / Virus stimulation, Condition and Cluster	ATP8B3 ZCWPW1 ST7 SLC16A4 PTPRK	7.31e-05	173	111	5	32b8e5b400885dbeba57a7cb2c18d882664dc285
ToppCell	FLU-Healthy-3\|Healthy / Virus stimulation, Condition and Cluster	ATP8B3 ZCWPW1 ST7 SLC16A4 PTPRK	7.31e-05	173	111	5	26e89ac86922f1cd0100cf4d1cce37e74dd31c88
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-14\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ST7L SBNO2 MEST EFNA4 PTPRK	7.72e-05	175	111	5	87e557f7508c88b2087db5d57e77d5e2c92ca083
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM ACER3 SLC5A1 EFNA4 FGFR2	7.72e-05	175	111	5	c1a8a55af825d5913095f919fa860828df9c273e
ToppCell	droplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_ductal_cel\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGAM ACER3 SLC5A1 EFNA4 FGFR2	7.72e-05	175	111	5	78b453e220218c84557f244ef7a760e4a1952761
ToppCell	pdx-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ABCA1 ABL2 CNKSR3 AIG1 SLC13A5	7.93e-05	176	111	5	1e21f80cf0e695ffdd63e4a72cf1e3fa41b60341
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-early_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACHE SOX7 CLCN5 PTPRM MICAL3	7.93e-05	176	111	5	7292e014b8f697f0c2e9f47c48333de95cb44a69
ToppCell	facs-Marrow-KLS-18m-Lymphocytic-early_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACHE SOX7 CLCN5 PTPRM MICAL3	7.93e-05	176	111	5	88ca2f83d8301633232735f39b0683efe49d0b86
ToppCell	Healthy-RBC\|World / disease group, cell group and cell class	ACHE GLB1L WFIKKN1 MAP2K3 EPB42	8.15e-05	177	111	5	2ce41e37fa7139c7bd2b464bd86c5601dc501515
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PTPRM RBMS3 GRIP2 FGFR2	8.15e-05	177	111	5	91706bd0d4dda8d98843fb00b898d5aca4d66b64
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CDKN1C ERBB4 PTPRK FGFR3 FGFR2	8.59e-05	179	111	5	815b959ce8721c5ded70c0ca6e318dafc691746e
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ASIC2 PTPRU KL TRPM3 CNKSR3	8.59e-05	179	111	5	7954c0026754ab869b88ab7feb13c2f27d6e272d
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PTPRM TRPM3 GRIP2 FGFR2	9.05e-05	181	111	5	af92b8b7f455210dab502ef6964f3a0162180759
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	BRINP1 SLC5A1 TRPM3 FGFR3 SUFU	9.05e-05	181	111	5	c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell	390C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CDKN1C HECTD4 AR METTL25B SUOX	9.05e-05	181	111	5	9275531e896e118cee043ed94fd31a0070d9581c
ToppCell	COPD-Epithelial-Basal\|World / Disease state, Lineage and Cell class	PTPRK RBMS3 FGFR3 FGFR2 ADGRA3	9.05e-05	181	111	5	6d8a886b4afe729f8a05b9c0f4ea9375de735da4
ToppCell	wk_15-18-Hematologic-Meg-ery-Definitive_erythroblast\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	UBR2 ATG2B HECTD4 MAP2K3 EPB42	9.29e-05	182	111	5	93841f730ca1a735eaaf5f2ccbe5c45ab0e029d1
ToppCell	wk_20-22-Hematologic-Meg-ery-Definitive_erythroblast\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	UBR2 ATG2B HECTD4 MAP2K3 EPB42	9.29e-05	182	111	5	0c77ef4556c1d1512ebe9077df858b28f9e38dd5
ToppCell	facs-Skin-Anagen-3m-Epithelial-Basal_IFE\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SBNO2 GLUL FGFR2 MAP2K3 SLC2A12	9.29e-05	182	111	5	22d6f4790950508e8aa27e02a8133af5f53f13c8
ToppCell	Hippocampus-Neuronal-Inhibitory\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ERBB4 PTPRM RBMS3 GRIP2 GNAS	9.29e-05	182	111	5	b54ae650c04dfd0759c5f5e752b9bf684dd36516
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 SHD PTPRM RBMS3 GRIP2	9.29e-05	182	111	5	a3c5c0eff527c8d3848acda14af8f9e99c69b0de
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PTPRM RBMS3 GRIP2 FGFR2	9.53e-05	183	111	5	d2074b13b4831ec18c81273d9a1ff673c3f6a16d
ToppCell	droplet-Kidney-nan-21m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDKN1C ASIC2 ACHE SOX7 RBMS3	9.53e-05	183	111	5	f55081068213cc1cdb2acad58ff10f6b48b44c72
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L2-4_SST_AHR\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 SHD PTPRM RBMS3 GRIP2	9.78e-05	184	111	5	1158a55c1990fd23d270cb6510d0951c4bfcddc5
ToppCell	droplet-Heart-4Chambers-21m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDKN1C APLP2 NRP2 MEST SOX7	9.78e-05	184	111	5	f17d713af4a97dff4eeeab24c405677ef2ffcf84
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CDKN1C GLUL FGFR3 FGFR2 MOG	1.00e-04	185	111	5	b5277190866d9eb5b85eceaa5ba116ea6e6f286b
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	WWP2 MEST FGFR3 FGFR2 ADGRA3	1.00e-04	185	111	5	8ed10ba581849c9c4ac4397226be2b62b4b3b900
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PTPRM RBMS3 GLUL GRIP2	1.00e-04	185	111	5	79cff4f3c6ae8e5ea60e8eae082b9275f2679ee9
ToppCell	Fetal_29-31_weeks-Immune-enucleated_erythrocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HECTD4 SHISA7 MICAL3 MAP2K3 EPB42	1.00e-04	185	111	5	e8f7da9641b6cf1db1093b4f301ce828fd3a529c
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	ERBB4 PTPRK RBMS3 LIPH FGFR2	1.00e-04	185	111	5	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	WWP2 MEST FGFR3 FGFR2 ADGRA3	1.00e-04	185	111	5	b8052cebb73f41abe6faf0aa847be7c8ef23ae94
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABCA1 APLP2 NRP2 GLUL MERTK	1.03e-04	186	111	5	f73cb91e74a806858650ae97f543fc779ba4cff8
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABCA1 APLP2 NRP2 GLUL MERTK	1.03e-04	186	111	5	8694ca16c9780729f4fba67ba20e35745f1eb4e9
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PTPRM RBMS3 GRIP2 FGFR2	1.05e-04	187	111	5	d413fb4b1531b297af5012a392b88128510c2de8
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GLUL FGFR3 FGFR2 MERTK ADGRA3	1.05e-04	187	111	5	dd1d91f101b837bba513f77defa6e6902b2c0570
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GLUL FGFR3 FGFR2 MERTK ADGRA3	1.05e-04	187	111	5	ae90c263f80c36a410150d499e268d198944a3d9
ToppCell	COVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	PDE10A SOX7 PTPRM RBMS3 CNKSR3	1.05e-04	187	111	5	2d20193a6cacdfa4877457c97b0077408942186c
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PTPRM RBMS3 GLUL GRIP2	1.05e-04	187	111	5	d2ffb2f34f07b0dd5d3cb3ee0275f46ebecf4146
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	ERBB4 SLC5A1 AIG1 MICAL3 GRIP2	1.05e-04	187	111	5	78cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCell	COVID-19-Epithelial_cells-Airway_basal\|COVID-19 / group, cell type (main and fine annotations)	ERBB4 PTPRK RBMS3 FGFR3 FGFR2	1.05e-04	187	111	5	8407a82e98f56a94ea26562bcb6bbe00a8f41661
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ABCA1 RNF149 NRP2 GLUL MERTK	1.08e-04	188	111	5	3be2d50148daa4eddddc2c7f269f45c97f7e4931
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PTPRM RBMS3 GLUL GRIP2	1.08e-04	188	111	5	ee572246e0c2f41bdbc29a03edc67b831af95c09
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KAT2B GLUL FGFR3 FGFR2 MOG	1.08e-04	188	111	5	505b6b4277d7dea87aee27191d0acca67928b8e6
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ABCA1 ABL2 APLP2 GLUL MERTK	1.08e-04	188	111	5	5f6ad5d693145d846ca561c2fa55465a88e40b90
ToppCell	COPD-Epithelial-ATII\|COPD / Disease state, Lineage and Cell class	ERBB4 PTPRK LIPH CNKSR3 FGFR2	1.08e-04	188	111	5	eb6d79d733b53f64ca615bb777c64ed456866549
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 NRP2 PTPRM RBMS3 GRIP2	1.08e-04	188	111	5	3139540a656c0436b2123ea50741ff8d00112165
ToppCell	E12.5-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CDKN1C WWP2 MEST FGFR3 FGFR2	1.08e-04	188	111	5	9b95730ddd13eb4624321bab3ab4989414977ca3
ToppCell	PND07-28-samps-Mesenchymal-Matrix_fibroblast\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	CDKN1C BRINP1 NRP2 RBMS3 FGFR3	1.11e-04	189	111	5	dc5164591dea45b420798b94dda211be03daa70c
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 PTPRM RBMS3 GRIP2 FGFR2	1.11e-04	189	111	5	99a13b1b669b0cd36e3096632351d9ade25d1173
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CDKN1C PTPRK PTPRM FGFR3 FGFR2	1.14e-04	190	111	5	8aea807a2bcf0b653b4de6202b6ecb0f0683cc2e
ToppCell	Control-Epithelial-ATII\|Control / Disease state, Lineage and Cell class	ERBB4 PTPRK LIPH CNKSR3 FGFR2	1.14e-04	190	111	5	d50902a3abcc18aafa36d83cc2c6e07d7f7cb197
ToppCell	PND07-28-samps-Mesenchymal-Matrix_fibroblast-FB-3\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	CDKN1C BRINP1 NRP2 RBMS3 FGFR3	1.14e-04	190	111	5	1196b8ea2c44c7c80f5ee589dd517e6a413f2077
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KAT2B GLUL FGFR3 FGFR2 MOG	1.14e-04	190	111	5	2de8e4cfeee350a9a76af749d6ce58d948c129b8
ToppCell	facs-GAT-Fat-3m\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 ITCH APLP2 MEST GLUL	1.14e-04	190	111	5	1d92be1b41cff59e834a9d28868f554bd1f3e471
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ERBB4 AR PTPRM RBMS3 GRIP2	1.14e-04	190	111	5	8c9c230a509afaeee50644153974a5642b01a2b8
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-Immature_INs\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	ERBB4 SHD MEST GRIP2 GNAS	1.14e-04	190	111	5	842760bfe0a52e67bad800efa7d99448a4a23ebb
ToppCell	severe_COVID-19-RBC\|severe_COVID-19 / disease group, cell group and cell class (v2)	ACHE HECTD4 SHISA7 MAP2K3 EPB42	1.14e-04	190	111	5	3a5723c2daf58c1932edd70910db4b8b30f63f42
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ABCA1 PDE10A SBNO2 RBMS3 ADGRA3	1.16e-04	191	111	5	08720998aa55131d7377c4c67c4c935865bd7d79
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APLP2 SLC5A1 RBMS3 FGFR3 FGFR2	1.19e-04	192	111	5	f3133bbbf938a39062a9b1d1181003bb48174695
ToppCell	droplet-Mammary_Gland-nan-18m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APLP2 SBNO2 NRP2 SOX7 PTPRM	1.19e-04	192	111	5	945153c41dde6e90d103206955e1707b54eb0665
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	CDKN1C WWP2 CLCN5 FGFR2 FOXG1	1.19e-04	192	111	5	d0649410cf5eacdb0c1dce70e37c7473ef5fddfa
ToppCell	droplet-Mammary_Gland-nan-18m-Endothelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APLP2 SBNO2 NRP2 SOX7 PTPRM	1.19e-04	192	111	5	6ab50579c63f31ca2cd41063a99b129f11c07510
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	MBTPS1 SGSH HGSNAT GLB1 MAP4K2	1.19e-04	192	111	5	efbd52b3d2b6d3fb9ed6bc3f36aca9f4f1fcbc49
ToppCell	facs-Lung-nan-3m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APLP2 SOX7 PTPRK PTPRM ADGRA3	1.19e-04	192	111	5	4bab9754cfd8b9c2d7cc1490e8a29f58c3c26f6c
ToppCell	droplet-Heart-HEART-1m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDKN1C NRP2 MEST PTPRM GNAS	1.19e-04	192	111	5	9da21ce330f3b5661f159cf18d1c3e5ccc11d6dd
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D175\|Adult / Lineage, Cell type, age group and donor	ABCA1 TRAF3 ACER3 DCSTAMP GLUL	1.19e-04	192	111	5	733491e932350e3c216a626cc49c3cd3fe970a82
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLK APLP2 NRP2 MEST SOX7	1.19e-04	192	111	5	c157981b9a179925edcaabc0cb3b8805f0929004
ToppCell	Influenza_Severe-RBC\|Influenza_Severe / Disease group and Cell class	ACHE ATG2B MICAL3 MAP2K3 EPB42	1.19e-04	192	111	5	f19b6da3fd98da1a76d2570137a8f73a3850ebcb
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_ductal_cel\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APLP2 SLC5A1 RBMS3 FGFR3 FGFR2	1.22e-04	193	111	5	c13e2612330ca8b9a8c206e588b26025c4f5898c
Computational	Porins / transporters.	ERBB4 AR CLCN5 PTPRK PTPRM BTN1A1 FGFR3 FGFR2 MERTK	1.34e-05	211	74	9	MODULE_63
Computational	Genes in the cancer module 85.	ERBB4 EFNA4 FGFR3 FGFR2 MERTK	2.48e-05	51	74	5	MODULE_85
Computational	Genes in the cancer module 199.	ERBB4 EFNA4 FGFR3 FGFR2 MERTK	4.27e-05	57	74	5	MODULE_199
Computational	RTK signaling.	EFNA4 FGFR3 FGFR2 MERTK	2.71e-04	46	74	4	MODULE_259
Drug	Etifenin [63245-28-3]; Up 200; 12.4uM; HL60; HT_HG-U133A	NUDT18 ABL2 SGSH BRINP1 SBNO2 SLC16A4 TRPM3 CTAGE1 AIG1	6.07e-07	200	111	9	2477_UP
Drug	Glc-ceramide	MGAM MBTPS1 ACER3 ABCA12 MEST GLB1 SMPD1	8.86e-07	106	111	7	CID005319015
Drug	cerbroside	GLB1L DEGS1 SHD PRKD3 ARSA GLB1	2.10e-06	77	111	6	CID000025437
Drug	PPL-L-alanine	MGAM ACHE ST7 MECP2 PRKD3 FCSK	3.04e-06	82	111	6	CID000444773
Drug	C8-ceramide	MBTPS1 ABCA1 ACER1 ACER3 ABCA12 GLB1L DEGS1 PRKD3 ARSA GLB1 SMPD1 CERS1 MAP2K3	3.23e-06	556	111	13	CID000002508
Drug	0316684-0000 [391209-55-5]; Up 200; 10uM; PC3; HT_HG-U133A	MBTPS1 ABCA1 WWP2 METTL25B GLUL B9D1 MAP2K3 MAP4K2	4.83e-06	193	111	8	7098_UP
Drug	Ampicillin trihydrate [7177-48-2]; Up 200; 10uM; MCF7; HT_HG-U133A	NUDT18 CDKN1C ABCA1 ABCA12 PTPRU PDE10A FGFR2 FOXG1	5.62e-06	197	111	8	1530_UP
Drug	Pepstatin A [26305-03-3]; Down 200; 5.8uM; MCF7; HT_HG-U133A	ALKBH4 NUDT18 MBTPS1 SIGMAR1 PTPRU MECP2 MIA2 CLCN5	5.83e-06	198	111	8	4790_DN
Drug	phenyl glucoside	MGAM SLC5A1 KL GLB1	7.36e-06	26	111	4	CID000065080
Drug	AC1NS1NG	MGAM ERBB4 PRKD3 ARSA GLB1 SMPD1 MOG	7.86e-06	147	111	7	CID005327099
Drug	AC1Q7A0V	SIGMAR1 ACHE OPRL1	9.27e-06	9	111	3	CID000001250
Drug	meptazinol	SIGMAR1 ACHE OPRL1	9.27e-06	9	111	3	CID000041049
Drug	cyclamate	SIGMAR1 DEGS1 OPRL1 CLCN5	1.00e-05	28	111	4	CID000007533
Drug	normetazocine	SIGMAR1 ACHE OPRL1	1.32e-05	10	111	3	CID000001208
Drug	2-deoxy-D-galactopyranose	SIGMAR1 MAP4K3 WRN SLC5A1 OPRL1 SLC2A12	1.66e-05	110	111	6	CID000000040
Drug	omethoate	ACHE DEGS1 SMPD1	1.81e-05	11	111	3	CID000014210
Drug	vanadyl	MGAM ERBB4 WRN PDE10A PRKD3 PTPRK PTPRM MAP2K3 MOG	1.99e-05	307	111	9	CID000061671
Drug	alpha-bisabolene	MGAM BTN1A1	2.36e-05	2	111	2	CID000086597
Drug	pyridindolol	GLB1L GLB1	2.36e-05	2	111	2	CID005358591
Drug	4-aminomethyl-1,8-octanediamine	MGAM GLB1	2.36e-05	2	111	2	CID000094211
Drug	G(M1	SIGMAR1 ACHE DEGS1 OPRL1 ARSA GLB1	2.36e-05	117	111	6	CID005497107
Drug	pentaethylenehexamine	MGAM GLB1 GNAS	2.40e-05	12	111	3	CID000019990
Drug	AC1MMOKY	GLB1L GLB1 FOXG1	2.40e-05	12	111	3	CID003289210
Drug	AC1L1JCO	MBTPS1 GLB1L PRKD3 ARSA GLB1	3.31e-05	75	111	5	CID000004982
Drug	AC1LAHXK	ITCH DEGS1 ARSA GLB1 MOG	3.76e-05	77	111	5	CID000468793
Drug	(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Down 200; 11.8uM; PC3; HT_HG-U133A	CDKN1C ZCWPW1 SGSH GLB1L NRP2 PASK SMPD1	4.55e-05	193	111	7	3810_DN
Drug	Atovaquone [95233-18-4]; Down 200; 11uM; PC3; HT_HG-U133A	CDKN1C ABL2 SBNO2 PASK B9D1 FGFR2 MAP4K2	4.86e-05	195	111	7	4201_DN
Drug	AC1NPP2V	MBTPS1 ACER3 PRKD3 SMPD1 CERS1	5.09e-05	82	111	5	CID005207744
Drug	3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Up 200; 13.8uM; HL60; HT_HG-U133A	ABCA1 PTPN22 PDE10A ST7L OPRL1 SLC16A4 B9D1	5.19e-05	197	111	7	2204_UP
Drug	Doxylamine succinate [562-10-7]; Down 200; 10.2uM; MCF7; HT_HG-U133A	NUDT18 PTPRU AR PRKD3 MIA2 B9D1 MAP2K3	5.19e-05	197	111	7	1473_DN
Drug	4-methylumbelliferyl	MGAM SGSH KL ARSA GLB1	5.40e-05	83	111	5	CID000011833
Drug	Aminosweet	SIGMAR1 ACHE OPRL1 SMPD1	5.70e-05	43	111	4	CID000002242
Drug	NSC71948	ACHE APLP2 AR PRTFDC1 KAT2B FOXG1	5.97e-05	138	111	6	CID000415676
Drug	5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one	FGFR3 FGFR2 MERTK	6.03e-05	16	111	3	ctd:C561052
Drug	AC1L5AFV	GLB1 SMPD1	7.04e-05	3	111	2	CID000173737
Drug	P12-sulfatide	DEGS1 ARSA	7.04e-05	3	111	2	CID006439241
Drug	benthiocarb	ACHE AR	7.04e-05	3	111	2	ctd:C037925
Drug	magnesium	MGAM SIGMAR1 WRN PDE10A COQ2 PRTFDC1 OPRL1 PRKD3 PASK RBSN ARSA GLB1 TRPM3 GLUL SMPD1 FGFR3 FGFR2 MERTK	7.13e-05	1325	111	18	CID000000888
Drug	meprobamate	ACHE PTPRU NRP2 PTPRK PTPRM	7.14e-05	88	111	5	CID000004064
Drug	p-nitrophenyl	MGAM ACHE GLB1L SLC5A1 KL GLB1	8.17e-05	146	111	6	CID000007416
Drug	bromodeoxyuridine	CDKN1C ERBB4 ITCH MAP4K3 AR GLB1 FGFR2 MAP2K3 FOXG1	9.54e-05	376	111	9	CID000006035
Drug	AC1Q6XL6	DEGS1 ARSA GLB1 SMPD1	9.57e-05	49	111	4	CID000014445
Drug	ppcA	MGAM ARSA GLB1	1.03e-04	19	111	3	CID000125885
Drug	MoO2	SUOX GLUL SMPD1 FGFR3	1.12e-04	51	111	4	CID000029320
Drug	methylnaltrexone	SIGMAR1 OPRL1 SHD	1.21e-04	20	111	3	CID005361917
Drug	alpha-Te	ACHE DEGS1 SMPD1	1.21e-04	20	111	3	CID000023353
Drug	Sulf	DEGS1 ARSA BTN1A1 MOG	1.40e-04	54	111	4	CID003083599
Drug	HF-2	MGAM SMPD1	1.40e-04	4	111	2	CID000015602
Drug	decursin	ACHE AR	1.40e-04	4	111	2	ctd:C101278
Drug	AC1ND3F1	GLB1L GLB1	1.40e-04	4	111	2	CID004568967
Drug	3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea	FGFR3 FGFR2	1.40e-04	4	111	2	ctd:C568950
Drug	SB-357134	ACHE MEST	1.40e-04	4	111	2	CID006918553
Drug	4-aminophenyl-beta-D-galactopyranoside	MGAM GLB1	1.40e-04	4	111	2	CID000001685
Drug	AB-8	ACHE KL ARSA	1.41e-04	21	111	3	CID000449170
Drug	AC1L42QD	MGAM DEGS1 ARSA GLB1 SMPD1	1.58e-04	104	111	5	CID000177413
Drug	terbutylazine	ACHE AR GLUL	1.62e-04	22	111	3	ctd:C037565
Drug	beta-CNA	SIGMAR1 OPRL1 GNAS	1.86e-04	23	111	3	CID005486190
Drug	Parthenolide [20554-84-1]; Up 200; 16.2uM; PC3; HT_HG-U133A	CDKN1C ABL2 MECP2 MICAL3 FGFR2 MERTK	2.07e-04	173	111	6	5105_UP
Drug	DALDA	SIGMAR1 OPRL1 SHD	2.12e-04	24	111	3	CID000122222
Drug	3-PPP	SIGMAR1 PTPRU OPRL1	2.12e-04	24	111	3	CID000055445
Drug	isocyanomethane	MBTPS1 ACER1 KL	2.12e-04	24	111	3	CID000011646
Drug	pyrene	ACHE AR SLC5A1 NDUFAF1 WFIKKN1 SMPD1	2.27e-04	176	111	6	ctd:C030984
Drug	metkephamid acetate	SIGMAR1 OPRL1	2.33e-04	5	111	2	CID005464183
Drug	R-84760	SIGMAR1 OPRL1	2.33e-04	5	111	2	CID000133035
Drug	DALECK	SIGMAR1 OPRL1	2.33e-04	5	111	2	CID015942760
Drug	Chlorthalidone	NRP2 FGFR3	2.33e-04	5	111	2	ctd:D002752
Drug	GPA 1657	SIGMAR1 OPRL1	2.33e-04	5	111	2	CID000030503
Drug	CTK3E6448	SIGMAR1 OPRL1	2.33e-04	5	111	2	CID014774638
Drug	RLH-033	SIGMAR1 OPRL1	2.33e-04	5	111	2	CID000190867
Drug	physostigmine salicylate	ACHE MEST	2.33e-04	5	111	2	CID000005992
Drug	acetylarsenocholine	MGAM ACHE	2.33e-04	5	111	2	CID000162399
Drug	Mr2097	SIGMAR1 OPRL1	2.33e-04	5	111	2	CID005745592
Drug	AC1L2FKQ	SIGMAR1 OPRL1	2.33e-04	5	111	2	CID000020114
Drug	Tyr-tic-phe-phe-OH	SIGMAR1 OPRL1	2.33e-04	5	111	2	CID003035452
Drug	ICI 197067	SIGMAR1 OPRL1	2.33e-04	5	111	2	CID003081077
Drug	calystegine B(1	MGAM GLB1	2.33e-04	5	111	2	CID000164245
Drug	mirfentanil	SIGMAR1 OPRL1	2.33e-04	5	111	2	CID000060697
Drug	monomethylfumarate	AR MOG	2.33e-04	5	111	2	CID000061799
Drug	BRL 52537	SIGMAR1 OPRL1	2.33e-04	5	111	2	CID005244802
Drug	AC1L1TDW	SIGMAR1 OPRL1	2.33e-04	5	111	2	CID000060509
Drug	PrBCM	ACHE KL SMPD1	2.40e-04	25	111	3	CID000037396
Drug	Si-O	MGAM KAT2B KL	2.40e-04	25	111	3	CID000066241
Drug	difenoconazole	ABCA1 ACHE AR	2.40e-04	25	111	3	ctd:C115058
Drug	gefitinib	ERBB4 ITCH AR MEST SMPD1 FGFR3 MAP2K3	2.57e-04	255	111	7	CID000123631
Drug	p-nitrophenyl-alpha-D-glucopyranoside	MGAM GLB1L KL GLB1 TRPM3	2.62e-04	116	111	5	CID000065115
Drug	hydroxyl radicals	ATP8B3 MGAM ACHE SGSH GLB1L APLP2 PTPN22 PTPRU PDE10A COQ2 PRKD3 ARSA GLB1 PTPRK PTPRM SUOX SMPD1	2.63e-04	1341	111	17	CID000000961
Drug	Aspidium	ACER3 ST7L KL GLB1 SUOX BTN1A1	2.88e-04	184	111	6	CID000000815
Drug	Retinoic acid [302-79-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A	PTPRU SBNO2 SLC5A1 PASK AIG1 MAP4K2	2.97e-04	185	111	6	6243_UP
Drug	y BT	PTPRU KAT2B BTN1A1	3.03e-04	27	111	3	CID000447121
Drug	Tgg Tripeptide	SIGMAR1 SLC5A1 OPRL1	3.03e-04	27	111	3	CID000123715
Drug	SKF 10,047	SIGMAR1 PTPRU OPRL1	3.03e-04	27	111	3	CID000001235
Drug	atipamezole	SIGMAR1 AR OPRL1	3.03e-04	27	111	3	CID000071310
Drug	0175029-0000 [211245-78-2]; Down 200; 1uM; MCF7; HT_HG-U133A	TRAF3 SBNO2 PRKD3 EFNA4 SUOX FGFR3	3.32e-04	189	111	6	4716_DN
Drug	fenitrothion	ACHE AR SMPD1	3.38e-04	28	111	3	CID000031200
Drug	Tubocurarine chloride pentahydrate (+) [6989-98-6]; Up 200; 5.2uM; MCF7; HT_HG-U133A	ABCA12 SGSH GLB1L SBNO2 PRKD3 MIA2	3.42e-04	190	111	6	2887_UP
Drug	ponatinib	ERBB4 ABL2 FGFR3 FGFR2	3.43e-04	68	111	4	ctd:C545373
Drug	AC1L9KJW	AR GLB1	3.49e-04	6	111	2	CID000447173
Drug	Palifermin	FGFR3 FGFR2	3.49e-04	6	111	2	DB00039
Drug	NIH10236	SIGMAR1 OPRL1	3.49e-04	6	111	2	CID006439828
Drug	AC1L2OET	SIGMAR1 OPRL1	3.49e-04	6	111	2	CID000125331
Disease	Seizures	SIGMAR1 ACHE SGSH MECP2 DEGS1 NRP2 FCSK GLB1 TRPM3 GLUL FOXG1	6.25e-10	218	110	11	C0036572
Disease	Developmental Academic Disorder	SIGMAR1 ACHE MECP2 KL	4.04e-06	29	110	4	C1330966
Disease	Learning Disorders	SIGMAR1 ACHE MECP2 KL	4.04e-06	29	110	4	C0023186
Disease	Learning Disturbance	SIGMAR1 ACHE MECP2 KL	4.04e-06	29	110	4	C0751263
Disease	Adult Learning Disorders	SIGMAR1 ACHE MECP2 KL	4.04e-06	29	110	4	C0751262
Disease	Learning Disabilities	SIGMAR1 ACHE MECP2 KL	4.04e-06	29	110	4	C0751265
Disease	Isolated coronal synostosis	FGFR3 FGFR2	1.38e-05	2	110	2	cv:CN043619
Disease	Generalized seizures	SIGMAR1 ACHE MECP2 NRP2 FOXG1	3.91e-05	101	110	5	C0234533
Disease	Clonic Seizures	SIGMAR1 ACHE MECP2 NRP2 FOXG1	3.91e-05	101	110	5	C0234535
Disease	Convulsive Seizures	SIGMAR1 ACHE MECP2 NRP2 FOXG1	3.91e-05	101	110	5	C0751494
Disease	Seizures, Sensory	SIGMAR1 ACHE MECP2 NRP2 FOXG1	3.91e-05	101	110	5	C0751496
Disease	Non-epileptic convulsion	SIGMAR1 ACHE MECP2 NRP2 FOXG1	3.91e-05	101	110	5	C0751056
Disease	Atonic Absence Seizures	SIGMAR1 ACHE MECP2 NRP2 FOXG1	3.91e-05	101	110	5	C0751123
Disease	Complex partial seizures	SIGMAR1 ACHE MECP2 NRP2 FOXG1	3.91e-05	101	110	5	C0149958
Disease	Single Seizure	SIGMAR1 ACHE MECP2 NRP2 FOXG1	3.91e-05	101	110	5	C0751110
Disease	Nonepileptic Seizures	SIGMAR1 ACHE MECP2 NRP2 FOXG1	3.91e-05	101	110	5	C3495874
Disease	Visual seizure	SIGMAR1 ACHE MECP2 NRP2 FOXG1	3.91e-05	101	110	5	C0270824
Disease	Epileptic drop attack	SIGMAR1 ACHE MECP2 NRP2 FOXG1	3.91e-05	101	110	5	C0270846
Disease	Vertiginous seizure	SIGMAR1 ACHE MECP2 NRP2 FOXG1	3.91e-05	101	110	5	C0422855
Disease	Gustatory seizure	SIGMAR1 ACHE MECP2 NRP2 FOXG1	3.91e-05	101	110	5	C0422854
Disease	Seizures, Somatosensory	SIGMAR1 ACHE MECP2 NRP2 FOXG1	3.91e-05	101	110	5	C0422850
Disease	Olfactory seizure	SIGMAR1 ACHE MECP2 NRP2 FOXG1	3.91e-05	101	110	5	C0422853
Disease	Seizures, Auditory	SIGMAR1 ACHE MECP2 NRP2 FOXG1	3.91e-05	101	110	5	C0422852
Disease	Generalized Absence Seizures	SIGMAR1 ACHE MECP2 NRP2 FOXG1	3.91e-05	101	110	5	C4505436
Disease	Jacksonian Seizure	SIGMAR1 ACHE MECP2 NRP2 FOXG1	3.91e-05	101	110	5	C0022333
Disease	Epileptic Seizures	SIGMAR1 ACHE MECP2 NRP2 FOXG1	3.91e-05	101	110	5	C4317109
Disease	Absence Seizures	SIGMAR1 ACHE MECP2 NRP2 FOXG1	4.10e-05	102	110	5	C4316903
Disease	Convulsions	SIGMAR1 ACHE MECP2 NRP2 FOXG1	4.10e-05	102	110	5	C4048158
Disease	Tonic Seizures	SIGMAR1 ACHE MECP2 NRP2 FOXG1	4.10e-05	102	110	5	C0270844
Disease	Lacrimoauriculodentodigital syndrome	FGFR3 FGFR2	4.12e-05	3	110	2	C0265269
Disease	Rett syndrome (implicated_via_orthology)	MECP2 FOXG1	4.12e-05	3	110	2	DOID:1206 (implicated_via_orthology)
Disease	Levy-Hollister syndrome	FGFR3 FGFR2	4.12e-05	3	110	2	cv:C0265269
Disease	Saethre-Chotzen Syndrome	FGFR3 FGFR2	4.12e-05	3	110	2	C0175699
Disease	Congenital hypoplasia of radius	FGFR3 FGFR2	4.12e-05	3	110	2	C0685381
Disease	Seizures, Focal	SIGMAR1 ACHE MECP2 NRP2 FOXG1	4.51e-05	104	110	5	C0751495
Disease	Myoclonic Seizures	SIGMAR1 ACHE MECP2 NRP2 FOXG1	4.51e-05	104	110	5	C4317123
Disease	Tonic - clonic seizures	SIGMAR1 ACHE MECP2 NRP2 FOXG1	4.51e-05	104	110	5	C0494475
Disease	Alcoholic Intoxication, Chronic	SIGMAR1 PDE10A AR OPRL1 ARSA GLUL MOG	6.77e-05	268	110	7	C0001973
Disease	TWIST1-related craniosynostosis	FGFR3 FGFR2	8.22e-05	4	110	2	cv:C4551902
Disease	MPS III D	SGSH HGSNAT	8.22e-05	4	110	2	C0086650
Disease	MPS III C	SGSH HGSNAT	8.22e-05	4	110	2	C0086649
Disease	MPS III B	SGSH HGSNAT	8.22e-05	4	110	2	C0086648
Disease	Mucopolysaccharidosis Type IIIA	SGSH HGSNAT	8.22e-05	4	110	2	C0086647
Disease	Sanfilippo syndrome	SGSH HGSNAT	8.22e-05	4	110	2	cv:C0026706
Disease	Mucopolysaccharidosis III	SGSH HGSNAT	8.22e-05	4	110	2	C0026706
Disease	Osteoarthritis, Knee	WWP2 SBNO1	8.22e-05	4	110	2	C0409959
Disease	mucopolysaccharidosis III (implicated_via_orthology)	SGSH HGSNAT	8.22e-05	4	110	2	DOID:12801 (implicated_via_orthology)
Disease	Premature aging syndrome	WRN KL	8.22e-05	4	110	2	C0231341
Disease	Acrocallosal Syndrome	SUFU FOXG1	8.22e-05	4	110	2	C0796147
Disease	bone disease (implicated_via_orthology)	FGFR3 FGFR2	1.37e-04	5	110	2	DOID:0080001 (implicated_via_orthology)
Disease	Spinal muscular atrophy, Jerash type	SIGMAR1 FBXO38	1.37e-04	5	110	2	C1854023
Disease	FEV/FEC ratio	MGAM ITCH BRINP1 CLVS1 NRP2 PTPRM SUOX RBMS3 CTAGE1 MICAL3 FGFR3 WDR41 FGFR2 SUFU	1.92e-04	1228	110	14	EFO_0004713
Disease	Squamous cell carcinoma of lung	ERBB4 MAP4K3 FGFR2	2.31e-04	32	110	3	C0149782
Disease	arabinose measurement	ERBB4 ABCA1	2.86e-04	7	110	2	EFO_0021030
Disease	Craniosynostosis syndrome	FGFR3 FGFR2	2.86e-04	7	110	2	cv:C0010278
Disease	docosahexaenoic acid measurement, sex interaction measurement	PTPRM CTAGE1	2.86e-04	7	110	2	EFO_0007761, EFO_0008343
Disease	myasthenia gravis (is_implicated_in)	ACHE PTPN22	3.80e-04	8	110	2	DOID:437 (is_implicated_in)
Disease	Alcohol withdrawal syndrome	AR GLUL	3.80e-04	8	110	2	C0236663
Disease	allergic disease	TRAF3 GLB1 PTPRK SUOX SBNO1 SUFU	4.23e-04	258	110	6	MONDO_0005271
Disease	ciliopathy (implicated_via_orthology)	MAP4K3 B9D1 MAP4K2	4.50e-04	40	110	3	DOID:0060340 (implicated_via_orthology)
Disease	Schizophrenia	CDKN1C ERBB4 ABCA1 SIGMAR1 ACHE SBNO2 SBNO1 GLUL FGFR2 GNAS MOG	4.67e-04	883	110	11	C0036341
Disease	complement factor H measurement	ERBB4 FBXO38 RBMS3	4.85e-04	41	110	3	EFO_0008097
Disease	Prostatic Cancer, Castration-Resistant	AR ZNF367	4.87e-04	9	110	2	C3658266
Disease	Prostatic Neoplasms, Castration-Resistant	AR ZNF367	4.87e-04	9	110	2	C3658267
Disease	coronary artery disease (is_implicated_in)	ABCA1 WRN PTPN22 KL	5.44e-04	100	110	4	DOID:3393 (is_implicated_in)
Disease	Memory Loss	SIGMAR1 ACHE KL	5.58e-04	43	110	3	C0751295
Disease	Age-Related Memory Disorders	SIGMAR1 ACHE KL	5.58e-04	43	110	3	C0751292
Disease	Memory Disorder, Spatial	SIGMAR1 ACHE KL	5.58e-04	43	110	3	C0751294
Disease	Memory Disorder, Semantic	SIGMAR1 ACHE KL	5.58e-04	43	110	3	C0751293
Disease	Memory Disorders	SIGMAR1 ACHE KL	5.58e-04	43	110	3	C0025261
Disease	mean arterial pressure	SLK HECTD4 PDE10A ST7L PRKD3 FCSK GNAS MERTK	5.75e-04	499	110	8	EFO_0006340
Disease	Memory impairment	SIGMAR1 ACHE KL	5.97e-04	44	110	3	C0233794
Disease	QT interval, particulate matter air pollution measurement	ERBB4 ARSA	6.08e-04	10	110	2	EFO_0004682, EFO_0008255
Disease	electrocardiography	SLK ACHE TRPM3 CTAGE1 GLUL FGFR2 SUFU ZNF367	8.49e-04	530	110	8	EFO_0004327
Disease	craniosynostosis (is_implicated_in)	FGFR3 FGFR2	8.87e-04	12	110	2	DOID:2340 (is_implicated_in)
Disease	membranous glomerulonephritis (biomarker_via_orthology)	ABCA1 PTPRU	1.22e-03	14	110	2	DOID:10976 (biomarker_via_orthology)
Disease	Eczema, allergic rhinitis	TRAF3 GLB1 PTPRK SUOX SUFU	1.29e-03	215	110	5	EFO_0005854, HP_0000964
Disease	Generalized hypotonia	FCSK TRPM3	1.40e-03	15	110	2	C1858120
Disease	polycystic ovary syndrome	ERBB4 ASIC2 SUOX	1.48e-03	60	110	3	EFO_0000660
Disease	Brachycephaly	FGFR3 FGFR2	1.81e-03	17	110	2	C0221356
Disease	Profound Mental Retardation	MECP2 FGFR2 GNAS FOXG1	1.85e-03	139	110	4	C0020796
Disease	Mental Retardation, Psychosocial	MECP2 FGFR2 GNAS FOXG1	1.85e-03	139	110	4	C0025363
Disease	Mental deficiency	MECP2 FGFR2 GNAS FOXG1	1.85e-03	139	110	4	C0917816
Disease	aspartate aminotransferase measurement	ABCA1 HECTD4 ST7L ARSA GLB1 TRPM3 RBMS3 CNKSR3 WDR41 MERTK	2.06e-03	904	110	10	EFO_0004736
Disease	Meningioma	WRN SUFU	2.26e-03	19	110	2	C0025286
Disease	citrulline measurement	SOX7 RBMS3	2.50e-03	20	110	2	EFO_0009777
Disease	Amphetamine-Related Disorders	ACHE DCSTAMP TRPM3	2.80e-03	75	110	3	C0236733
Disease	Amphetamine Abuse	ACHE DCSTAMP TRPM3	2.80e-03	75	110	3	C0236807
Disease	Amphetamine Addiction	ACHE DCSTAMP TRPM3	2.80e-03	75	110	3	C0236804
Disease	Craniofacial Abnormalities	TBX15 MBTPS1 MECP2 FGFR2	2.81e-03	156	110	4	C0376634
Disease	osteoarthritis, knee	WWP2 SBNO1 CNKSR3 FGFR3	2.94e-03	158	110	4	EFO_0004616
Disease	tonsillectomy risk measurement	TBX15 HECTD4 SBNO2 TRPM3 MOG	2.95e-03	260	110	5	EFO_0007924
Disease	Autistic Disorder	ASIC2 MECP2 AR NRP2 PASK	3.00e-03	261	110	5	C0004352
Disease	Disproportionate short stature	CDKN1C FGFR3 FGFR2	3.02e-03	77	110	3	C0878659
Disease	renal system measurement, blood urea nitrogen measurement	HECTD4 GNAS	3.03e-03	22	110	2	EFO_0004741, EFO_0004742
Disease	Renal glomerular disease	CDKN1C CLCN5	3.31e-03	23	110	2	C0268731
Disease	Ovarian Serous Adenocarcinoma	SLK FGFR2	3.31e-03	23	110	2	C1335177
Disease	Glomerulopathy Assessment	CDKN1C CLCN5	3.31e-03	23	110	2	C4521256
Disease	Neoplasm of the genitourinary tract	AR FGFR3	3.60e-03	24	110	2	cv:C0042065
Disease	Intrahepatic Cholangiocarcinoma	FGFR2 GNAS	3.60e-03	24	110	2	C0345905

Protein segments in the cluster

Peptide	Gene	Start	Entry
PLWMGVPHGYEIEFI	ACHE	471	P22303
SDFEGWAFPFPGVML	ALKBH4	61	Q9NXW9
WELMTFGGKPYDGIP	ERBB4	911	Q15303
ECWMTRPALPQGYDG	EPB42	331	P16452
MAPAADREGYWGPTT	ACER3	1	Q9NUN7
GMWVYPFLEHIGPGA	AIG1	181	Q9NVV5
MRPDSHPYGFPWELV	CTAGE1	1	Q96RT6
WEIATYGMSPYPGID	ABL2	476	P42684
NMPFGEFGYPRWEKI	BRINP1	576	O60477
SIWMPRCYFPSFLGG	ACER1	101	Q8TDN7
PMTPENGFWAVELYG	BTN1A1	386	Q13410
LGPAGPFDMVYWTGD	SMPD1	266	P17405
VRNVFPGTYGMAAPW	ABCA12	1271	Q86UK0
MAWEPSLGAFYGPAS	ADGRA3	911	Q8IWK6
PGPRADPFEDMRYVW	ABCA1	576	O95477
EVYTAWPMAGFPGGK	SPATA5	96	Q8NB90
KYEWRPEGPTSMGSL	ATP8B3	76	O60423
PRPATGSEPMYWSSF	ATG2B	106	Q96BY7
YLPPPWGECRSSEMG	ASIC2	281	Q16515
LEDQYFPWRVTMPGE	RCC1L	431	Q96I51
YGRGVVIMDDWPGYD	PRTFDC1	11	Q9NRG1
RPWPREGEAGMALTY	RBMS3	241	Q6XE24
FSYGGVDPYMWEPQE	RBSN	81	Q9H1K0
RYWAEPGEMQLEFGP	PTPN22	141	Q9Y2R2
YVAAFSIGLGPMPWL	SLC2A12	471	Q8TD20
FIGTPYWMAPEVAAV	MAP4K2	171	Q12851
TGPCRAVMPRWYFDL	APLP2	316	Q06481
VLMWEIFTLGGSPYP	FGFR2	691	P21802
FILYLVPPWDRSMGG	OGFOD1	166	Q8N543
VPPWDRSMGGTLDLY	OGFOD1	171	Q8N543
AEPGCFPDWYMLSLF	COQ2	101	Q96H96
FIGTPYWMAPEVAAV	MAP4K3	171	Q8IVH8
GNPYRGPELEMWSLG	PASK	1176	Q96RG2
LEPFWPMGTGIARGF	MICAL3	401	Q7RTP6
TTWELPGGYGRMKPD	MBTPS1	376	Q14703
PKFYGIGENMWVGPE	GLIPR1L2	111	Q4G1C9
WPFMEPVKRTEAPGY	KAT2B	746	Q92831
ECRGSWYLPAGRMEP	NUDT18	66	Q6ZVK8
WYLPAGRMEPGETIV	NUDT18	71	Q6ZVK8
WEIATRGMTPYPGVQ	MERTK	791	Q12866
ELIGRPVMVPYWSLG	MGAM	1231	O43451
RPGPYICAEWEMGGL	GLB1	121	P16278
DRAGSLYWPMSPFLS	FOXG1	301	P55316
HFDIGPFENMWPGIF	PDE10A	466	Q9Y233
EIYVSPRSPGWMDFI	DCSTAMP	16	Q9H295
PPEGPETFALYMVDW	EFNA4	66	P52798
VRVYPERWSPAGIGM	NRP2	571	O60462
FMYPPNPWREISGEA	PRKD3	791	O94806
MYDGWLGRITGLDPA	LIPH	166	Q8WWY8
MPGEGEVVRYRSVWP	METTL25B	71	Q96FB5
DFTAPDVWYPGGMVS	AR	496	P10275
PPWLPGLEARYMAFA	ARSA	191	P15289
LSPYLEDVSGGMWPV	HECTD4	2101	Q9Y4D8
ATGMEVGWYRPPFSR	MOG	61	Q16653
YWPEPGRQQYGLMEV	PTPRU	1291	Q92729
GAPYSMISDFPWLRS	FBXO38	1096	Q6PIJ6
PEGWEMRFTVDGIPY	ITCH	481	Q96J02
SGPAANPEWMRPFSY	FCSK	626	Q8N0W3
NPEWMRPFSYLECGD	FCSK	631	Q8N0W3
WDYDFQQDMPLRGPG	CDKN1C	61	P49918
ILPQGEYPEYQRWMG	CRYGS	61	P22914
PDRPAGVGVYSAMWQ	CLCN5	486	P51795
MFTRGGPYWQEVKIP	NDUFAF1	241	Q9Y375
GPYICAEWEMGGLPS	GLB1L	121	Q6UWU2
RWFGMFANLPIGIPY	DEGS1	106	O15121
YDWTPGMAVPRDIAA	CERS1	136	P27544
AEPIFGSGDYPWVMR	KL	761	Q9UEF7
VKGLWTGTPFFYPGM	HGSNAT	591	Q68CP4
CFWYIPPSLREMEEG	GADL1	441	Q6ZQY3
VDTGAPYWTRPERMD	FGFR3	146	P22607
PGPAREEGFWRMFGE	GRIP2	861	Q9C0E4
WFMGRRPEYTDPKVV	B9D1	136	Q9UPM9
FSRDPGFMPGWLTVA	SLC13A5	331	Q86YT5
AYMNRLGIWGEGTPF	SBNO1	486	A3KN83
FGPYTRPSESELWDM	MEST	221	Q5EB52
PYWMAPEVINESGYG	MAP3K19	1231	Q56UN5
WPEEGMLRYGPIQVE	PTPRK	1286	Q15262
FQFLGWPMYRDTPVS	PTPRM	1346	P28827
RGPMYDDPTLPEGWT	MECP2	91	P51608
EGMRPDSNLYGFPWE	MIA2	636	Q96PC5
MAILRFPYESWGTPF	MAP2K3	261	P46734
MEPLFPAPFWEVIYG	OPRL1	1	P41146
EYTLMGTDGHPFGWP	GLUL	136	P15104
PGFEYFSPMPAWAQD	RPUSD2	526	Q8IZ73
MASLLGAYPWPEGLE	SOX7	1	Q9BT81
PYDAQWVMSELPGRG	SHD	126	Q96IW2
RRDSFIGTPYWMAPE	SLK	186	Q9H2G2
DWERPGSPPSYEEAM	TAGAP	586	Q8N103
MWIPGFGSEEIRPYK	TAF12	126	Q16514
AMPFEAEQPSLGGFW	GNAS	101	Q5JWF2
GLEAIMETYAFWRPP	TBX15	311	Q96SF7
PNTWMVEYGRGVIPS	SIGMAR1	166	Q99720
YRMEAWGGPEELGLA	SHISA7	361	A6NL88
IYMSRLGIWGEGTPF	SBNO2	431	Q9Y2G9
GDVVGFDMEWPPLYN	WRN	76	Q14191
WEGTFRMIPYPLEKG	ST7	466	Q9NRC1
TWLCGEPGPYMDVVV	PI4KAP2	511	A4QPH2
ESGMGRIPDWTPQAY	SGSH	201	P51688
ADGNWMGIVDPFARP	CNK3/IPCEF1	436	G9CGD6
ADGNWMGIVDPFARP	CNKSR3	436	Q6P9H4
FGGTLPPYDMGTWAR	CLVS1	271	Q8IUQ0
ALGYWGEPGDVQEMP	RNF149	316	Q8NC42
VIMRGEYDALLPWPF	TRAF3	476	Q13114
LPPGWEMKYTSEGVR	WWP2	446	O00308
WPGMIESDPDLGEYF	ZCWPW1	331	Q9H0M4
MAVLSGPPIAGWLYD	SLC16A4	436	O15374
MPEPWGTVYFLGIAQ	TRPM3	1	Q9HCF6
WLGGPDPLDYVSMYR	SUFU	61	Q9UMX1
CTWEGTFRMIPYPLE	ST7L	461	Q8TDW4
LWHYDPQRGGCMTFP	WFIKKN1	316	Q96NZ8
MLAAGGPLEPFWALY	SUOX	126	P51687
PGFSDFMVYPWRWGE	ZNF367	61	Q7RTV3
TGDLPWPGFIFGMSI	SLC5A1	271	P13866
GPMEWYLCGEDPAFG	UBR2	71	Q8IWV8
PVPTGFFNMWGFGRV	WDR41	361	Q9HAD4
PGDDPMGYESSAERW	UBE2G2	96	P60604