Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	coumarin 7-hydroxylase activity	CYP2A6 CYP2A7	5.36e-05	3	85	2	GO:0008389
GeneOntologyMolecularFunction	monooxygenase activity	CYP2A6 CYP2A7 FMO2 FMO5 PAH	1.32e-04	115	85	5	GO:0004497
GeneOntologyMolecularFunction	hypotaurine monooxygenase activity	FMO2 FMO5	1.78e-04	5	85	2	GO:0047822
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	MLH3 VPS72 CHD1 CHD2 CDK7	2.10e-04	127	85	5	GO:0008094
GeneOntologyMolecularFunction	N,N-dimethylaniline monooxygenase activity	FMO2 FMO5	2.66e-04	6	85	2	GO:0004499
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	VPS72 CHD1 CHD2	5.21e-04	37	85	3	GO:0140658
GeneOntologyMolecularFunction	structural constituent of muscle	DMD MYBPC2 MYBPC3	8.12e-04	43	85	3	GO:0008307
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	MLH3 ERCC4 VPS72 CHD1 CHD2 CDK7	8.87e-04	262	85	6	GO:0140097
GeneOntologyCellularComponent	Cul4A-RING E3 ubiquitin ligase complex	CUL4B CUL4A GLMN	2.37e-05	14	86	3	GO:0031464
GeneOntologyCellularComponent	sarcomere	CACNA1D DST PYROXD1 SPTAN1 DMD MYBPC2 MYBPC3	7.55e-05	249	86	7	GO:0030017
GeneOntologyCellularComponent	myofibril	CACNA1D DST PYROXD1 SPTAN1 DMD MYBPC2 MYBPC3	1.34e-04	273	86	7	GO:0030016
GeneOntologyCellularComponent	contractile muscle fiber	CACNA1D DST PYROXD1 SPTAN1 DMD MYBPC2 MYBPC3	1.94e-04	290	86	7	GO:0043292
GeneOntologyCellularComponent	Cul4-RING E3 ubiquitin ligase complex	CUL4B CUL4A GLMN	5.11e-04	38	86	3	GO:0080008
Domain	DUF4208	CHD1 CHD2	6.27e-05	3	86	2	PF13907
Domain	DUF4208	CHD1 CHD2	6.27e-05	3	86	2	SM01176
Domain	DUF4208	CHD1 CHD2	6.27e-05	3	86	2	IPR025260
Domain	Cyt_P450_E_grp-I_CYP2A-like	CYP2A6 CYP2A7	1.25e-04	4	86	2	IPR008067
Domain	Spectrin	DST SPTAN1 DMD	1.56e-04	23	86	3	PF00435
Domain	FMO-like	FMO2 FMO5	2.08e-04	5	86	2	PF00743
Domain	Flavin_mOase	FMO2 FMO5	2.08e-04	5	86	2	IPR000960
Domain	Flavin_mOase-like	FMO2 FMO5	2.08e-04	5	86	2	IPR020946
Domain	DiMe-aniline_mOase	FMO2 FMO5	2.08e-04	5	86	2	IPR012143
Domain	Spectrin_repeat	DST SPTAN1 DMD	3.16e-04	29	86	3	IPR002017
Domain	Spectrin/alpha-actinin	DST SPTAN1 DMD	4.25e-04	32	86	3	IPR018159
Domain	SPEC	DST SPTAN1 DMD	4.25e-04	32	86	3	SM00150
Domain	Cullin_CS	CUL4B CUL4A	4.34e-04	7	86	2	IPR016157
Domain	CULLIN	CUL4B CUL4A	4.34e-04	7	86	2	SM00182
Domain	Cullin_Nedd8	CUL4B CUL4A	5.76e-04	8	86	2	PF10557
Domain	Cullin_Nedd8	CUL4B CUL4A	5.76e-04	8	86	2	SM00884
Domain	Cullin_neddylation_domain	CUL4B CUL4A	5.76e-04	8	86	2	IPR019559
Domain	Cullin_homology	CUL4B CUL4A	7.39e-04	9	86	2	IPR016158
Domain	Cullin	CUL4B CUL4A	9.21e-04	10	86	2	PF00888
Domain	CULLIN_2	CUL4B CUL4A	9.21e-04	10	86	2	PS50069
Domain	Cullin_N	CUL4B CUL4A	9.21e-04	10	86	2	IPR001373
Domain	CULLIN_1	CUL4B CUL4A	9.21e-04	10	86	2	PS01256
Domain	Cullin_repeat-like_dom	CUL4B CUL4A	1.34e-03	12	86	2	IPR016159
Domain	-	FMO2 FMO5 PYROXD1	2.19e-03	56	86	3	3.50.50.60
Domain	FAD/NAD-binding_dom	FMO2 FMO5 PYROXD1	2.31e-03	57	86	3	IPR023753
Domain	Chromodomain_CS	CHD1 CHD2	3.06e-03	18	86	2	IPR023779
Domain	CH	MAPRE3 DST DMD	4.13e-03	70	86	3	PF00307
Domain	-	MAPRE3 DST DMD	4.30e-03	71	86	3	1.10.418.10
Domain	CH	MAPRE3 DST DMD	4.65e-03	73	86	3	PS50021
Domain	Actinin_actin-bd_CS	DST DMD	4.98e-03	23	86	2	IPR001589
Domain	ACTININ_2	DST DMD	4.98e-03	23	86	2	PS00020
Domain	ACTININ_1	DST DMD	4.98e-03	23	86	2	PS00019
Domain	CH-domain	MAPRE3 DST DMD	5.01e-03	75	86	3	IPR001715
Domain	Chromo_domain	CHD1 CHD2	5.42e-03	24	86	2	IPR023780
Domain	Chromo	CHD1 CHD2	6.34e-03	26	86	2	PF00385
Domain	fn3	PTPRJ IL7R MYBPC2 MYBPC3	6.67e-03	162	86	4	PF00041
Domain	CHROMO_1	CHD1 CHD2	7.33e-03	28	86	2	PS00598
Domain	CHROMO_2	CHD1 CHD2	7.33e-03	28	86	2	PS50013
Pathway	REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER	CUL4B CUL4A ERCC4 CDK7	5.94e-05	43	70	4	M1005
Pathway	KEGG_NUCLEOTIDE_EXCISION_REPAIR	CUL4B CUL4A ERCC4 CDK7	6.51e-05	44	70	4	M18937
Pathway	WP_NUCLEOTIDE_EXCISION_REPAIR	CUL4B CUL4A ERCC4 CDK7	6.51e-05	44	70	4	M39847
Pathway	REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER	CUL4B CUL4A ERCC4 CDK7	7.12e-05	45	70	4	MM15302
Pathway	WP_CATALYTIC_CYCLE_OF_MAMMALIAN_FLAVINCONTAINING_MONOOXYGENASES_FMOS	FMO2 FMO5	2.41e-04	5	70	2	M39449
Pathway	REACTOME_DUAL_INCISION_IN_TC_NER	CUL4B CUL4A ERCC4 CDK7	2.66e-04	63	70	4	MM15317
Pathway	REACTOME_DUAL_INCISION_IN_TC_NER	CUL4B CUL4A ERCC4 CDK7	2.66e-04	63	70	4	M27601
Pathway	KEGG_DRUG_METABOLISM_CYTOCHROME_P450	CYP2A6 CYP2A7 FMO2 FMO5	4.45e-04	72	70	4	M9257
Pathway	WP_NUCLEOTIDE_EXCISION_REPAIR_IN_XERODERMA_PIGMENTOSUM	CUL4B CUL4A ERCC4 CDK7	5.20e-04	75	70	4	M42538
Pathway	REACTOME_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR_TC_NER	CUL4B CUL4A ERCC4 CDK7	5.20e-04	75	70	4	MM15316
Pathway	REACTOME_TRANSCRIPTION_COUPLED_NUCLEOTIDE_EXCISION_REPAIR_TC_NER	CUL4B CUL4A ERCC4 CDK7	5.46e-04	76	70	4	M27600
Pathway	REACTOME_STRIATED_MUSCLE_CONTRACTION	DMD MYBPC2 MYBPC3	6.85e-04	35	70	3	MM15005
Pathway	REACTOME_STRIATED_MUSCLE_CONTRACTION	DMD MYBPC2 MYBPC3	7.44e-04	36	70	3	M18647
Pathway	REACTOME_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR_GG_NER	CUL4B CUL4A ERCC4 CDK7	7.62e-04	83	70	4	MM15305
Pathway	REACTOME_GLOBAL_GENOME_NUCLEOTIDE_EXCISION_REPAIR_GG_NER	CUL4B CUL4A ERCC4 CDK7	7.98e-04	84	70	4	M27594
Pathway	REACTOME_RHOV_GTPASE_CYCLE	DLG5 DST SPTAN1	8.07e-04	37	70	3	M41819
Pathway	REACTOME_RHOV_GTPASE_CYCLE	DLG5 DST SPTAN1	8.07e-04	37	70	3	MM15610
Pathway	WP_STRIATED_MUSCLE_CONTRACTION_PATHWAY	DMD MYBPC2 MYBPC3	8.73e-04	38	70	3	M39549
Pathway	REACTOME_RHOU_GTPASE_CYCLE	DLG5 DST SPTAN1	9.43e-04	39	70	3	MM15607
Pathway	REACTOME_RHOU_GTPASE_CYCLE	DLG5 DST SPTAN1	1.02e-03	40	70	3	M41816
Pathway	REACTOME_DUAL_INCISION_IN_GG_NER	CUL4B CUL4A ERCC4	1.09e-03	41	70	3	M27595
Pathway	REACTOME_DUAL_INCISION_IN_GG_NER	CUL4B CUL4A ERCC4	1.17e-03	42	70	3	MM15306
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_VPR_TO_CDC25_CELL_CYCLE_G2M	CUL4B CUL4A	1.30e-03	11	70	2	M47573
Pathway	REACTOME_CYP2E1_REACTIONS	CYP2A6 CYP2A7	1.30e-03	11	70	2	M27130
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	GLMN PACS1 DNAJC13 COPA PTPRJ RCAN1 COX4I1 SPTAN1 PRIM1 GRAMD1A PES1 RNF213 DMD CDC14A PPP4R3A	4.15e-08	1049	86	15	27880917
Pubmed	Differential expression of C-protein isoforms in developing and degenerating mouse striated muscles.	DMD MYBPC2 MYBPC3	1.45e-07	5	86	3	10024132
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	CUL4B CUL4A TRIM25 COPA PRIM1 PES1 RNF213 CHD1 CHD2 PPWD1 CWF19L1 SF3B2 PPP4R3A CDK7	1.89e-07	1014	86	14	32416067
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	DLG5 DST SPTAN1 RTTN RPS8 RNF213 DMD	4.36e-07	187	86	7	26460568
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	CUL4B CUL4A DNAJC13 TRIM25 COPA TBK1 SUGP1 DMD	7.87e-07	298	86	8	30737378
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	CUL4B DNAJC13 COPA TBK1 PES1 RPS8 RNF213 CHD1 CWF19L1 SF3B2	2.40e-06	601	86	10	33658012
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CUL4A PACS1 DNAJC13 DEPTOR PTPRJ TBK1 ANKRD11 RNF213 CHD2 ANKRD12 DAAM1 AADAT ATAT1 DOCK6 DNAH14	3.46e-06	1489	86	15	28611215
Pubmed	Identification of novel interactions between domains of Myosin binding protein-C that are modulated by hypertrophic cardiomyopathy missense mutations.	MYBPC2 MYBPC3	6.04e-06	2	86	2	12386147
Pubmed	Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.	CYP2A6 CYP2A7	6.04e-06	2	86	2	12325023
Pubmed	Parental attitudes regarding newborn screening of PKU and DMD.	PAH DMD	6.04e-06	2	86	2	12833401
Pubmed	CHD1 and CHD2 are positive regulators of HIV-1 gene expression.	CHD1 CHD2	6.04e-06	2	86	2	25297984
Pubmed	CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.	CYP2A6 CYP2A7	6.04e-06	2	86	2	16636685
Pubmed	Cardiac myosin binding protein-C plays no regulatory role in skeletal muscle structure and function.	DMD MYBPC3	6.04e-06	2	86	2	23936073
Pubmed	Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks.	CUL4B CUL4A	6.04e-06	2	86	2	20064923
Pubmed	Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer.	CUL4B CUL4A	6.04e-06	2	86	2	27974468
Pubmed	The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.	CYP2A6 CYP2A7	6.04e-06	2	86	2	2322567
Pubmed	Expression and alternative splicing of the cytochrome P-450 CYP2A7.	CYP2A6 CYP2A7	6.04e-06	2	86	2	7864805
Pubmed	Renal Na(+)-phosphate cotransporter gene expression in X-linked Hyp and Gy mice.	PHEX DMD	6.04e-06	2	86	2	8691720
Pubmed	Differential methylation of CpG sites in two isoforms of myosin binding protein C, an important hypertrophic cardiomyopathy gene.	MYBPC2 MYBPC3	6.04e-06	2	86	2	20740642
Pubmed	Localization of human flavin-containing monooxygenase genes FMO2 and FMO5 to chromosome 1q.	FMO2 FMO5	6.04e-06	2	86	2	8786146
Pubmed	Support for a trimeric collar of myosin binding protein C in cardiac and fast skeletal muscle, but not in slow skeletal muscle.	MYBPC2 MYBPC3	6.04e-06	2	86	2	18201573
Pubmed	Understanding the organisation and role of myosin binding protein C in normal striated muscle by comparison with MyBP-C knockout cardiac muscle.	MYBPC2 MYBPC3	6.04e-06	2	86	2	18817784
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	TRIM25 DST SPTAN1 PRIM1 RPS8 CHD1 DMD PPWD1 SF3B2	7.59e-06	538	86	9	28524877
Pubmed	KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR).	CUL4B CUL4A CDK7	9.68e-06	17	86	3	22902626
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DLG5 DNAJC13 DST COPA SPTAN1 PES1 RPS8 GPC4 SUGP1 CHD2 DOCK6 SF3B2	1.42e-05	1082	86	12	38697112
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DLG5 DNAJC13 TRIM25 WDR75 COX4I1 SPTAN1 GRAMD1A PES1 RPS8 ANKRD11 CHD1 DAAM1 RABL3 SF3B2	1.63e-05	1487	86	14	33957083
Pubmed	Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.	CYP2A6 CYP2A7	1.81e-05	3	86	2	31645370
Pubmed	CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.	CYP2A6 CYP2A7	1.81e-05	3	86	2	11960914
Pubmed	Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor.	CARS1 RNF213	1.81e-05	3	86	2	12112524
Pubmed	Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.	CYP2A6 CYP2A7	1.81e-05	3	86	2	3346244
Pubmed	CUL4high Lung Adenocarcinomas Are Dependent on the CUL4-p21 Ubiquitin Signaling for Proliferation and Survival.	CUL4B CUL4A	1.81e-05	3	86	2	34119472
Pubmed	Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.	CYP2A6 CYP2A7	1.81e-05	3	86	2	2733794
Pubmed	A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.	CYP2A6 CYP2A7	1.81e-05	3	86	2	8297477
Pubmed	Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.	CYP2A6 CYP2A7	1.81e-05	3	86	2	8188299
Pubmed	Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.	CYP2A6 CYP2A7	1.81e-05	3	86	2	8484736
Pubmed	Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.	CYP2A6 CYP2A7	1.81e-05	3	86	2	8250953
Pubmed	Unified single-cell analysis of testis gene regulation and pathology in five mouse strains.	CUL4A MLH3	1.81e-05	3	86	2	31237565
Pubmed	The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.	CYP2A6 CYP2A7	1.81e-05	3	86	2	2703500
Pubmed	CUL4 E3 ligase regulates the proliferation and apoptosis of lung squamous cell carcinoma and small cell lung carcinoma.	CUL4B CUL4A	1.81e-05	3	86	2	32587774
Pubmed	Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.	CYP2A6 CYP2A7	1.81e-05	3	86	2	1417950
Pubmed	Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.	CYP2A6 CYP2A7	1.81e-05	3	86	2	24045421
Pubmed	Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.	CYP2A6 CYP2A7	1.81e-05	3	86	2	32987105
Pubmed	Cullin4B/E3-ubiquitin ligase negatively regulates beta-catenin.	CUL4B CUL4A	1.81e-05	3	86	2	17954973
Pubmed	Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.	CYP2A6 CYP2A7	1.81e-05	3	86	2	22217847
Pubmed	Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.	CYP2A6 CYP2A7	1.81e-05	3	86	2	2765478
Pubmed	RIOK3 is an adaptor protein required for IRF3-mediated antiviral type I interferon production.	TBK1 RIOK3	1.81e-05	3	86	2	24807708
Pubmed	Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.	CYP2A6 CYP2A7	1.81e-05	3	86	2	2415518
Pubmed	A meta-analysis of genome-wide association studies identifies ORM1 as a novel gene controlling thrombin generation potential.	PTPRJ MYBPC3	1.81e-05	3	86	2	24357727
Pubmed	Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.	CYP2A6 CYP2A7	1.81e-05	3	86	2	22890016
Pubmed	CYP2A7 pseudogene transcript affects CYP2A6 expression in human liver by acting as a decoy for miR-126.	CYP2A6 CYP2A7	1.81e-05	3	86	2	25710939
Pubmed	Expression and clinical significance of IL7R, NFATc2, and RNF213 in familial and sporadic multiple sclerosis.	RNF213 IL7R	1.81e-05	3	86	2	34584155
Pubmed	E3 ubiquitin ligase Cullin4B mediated polyubiquitination of p53 for its degradation.	CUL4B CUL4A	1.81e-05	3	86	2	24452595
Pubmed	The immunity-related GTPase IRGC mediates interaction between lipid droplets and mitochondria to facilitate sperm motility.	COX4I1 IRGC	1.81e-05	3	86	2	37195149
Pubmed	CHD1 and SPOP synergistically protect prostate epithelial cells from DNA damage.	CHD1 CHD2	1.81e-05	3	86	2	33022763
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	VPS72 PES1 SUGP1 SF3B2 PPP4R3A	2.14e-05	134	86	5	25452129
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	CUL4B DNAJC13 WDR75 COPA SPTAN1 PES1 RPS8 SF3B2 PPP4R3A	2.91e-05	638	86	9	33239621
Pubmed	Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.	CUL4B CUL4A COPA SPTAN1 RPS8 RNF213 ACAP2 PPP4R3A	3.20e-05	495	86	8	28581483
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CUL4B DST WDR75 COPA SPTAN1 PES1 CHD1 CHD2 SF3B2	3.49e-05	653	86	9	22586326
Pubmed	The effect of maternal diabetes on the Wnt-PCP pathway during embryogenesis as reflected in the developing mouse eye.	GPC4 DAAM1	3.61e-05	4	86	2	25540130
Pubmed	Characterization of the CHD family of proteins.	CHD1 CHD2	3.61e-05	4	86	2	9326634
Pubmed	Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver.	CYP2A6 CYP2A7	3.61e-05	4	86	2	9408084
Pubmed	Inflammation-dependent downregulation of miR-194-5p contributes to human intervertebral disc degeneration by targeting CUL4A and CUL4B.	CUL4B CUL4A	3.61e-05	4	86	2	30945295
Pubmed	Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP.	CYP2A6 CYP2A7	3.61e-05	4	86	2	10490589
Pubmed	Proximity Labeling, Quantitative Proteomics, and Biochemical Studies Revealed the Molecular Mechanism for the Inhibitory Effect of Indisulam on the Proliferation of Gastric Cancer Cells.	CUL4B CUL4A	3.61e-05	4	86	2	34420308
Pubmed	Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice.	CYP2A6 CYP2A7	3.61e-05	4	86	2	1970547
Pubmed	CRL4s: the CUL4-RING E3 ubiquitin ligases.	CUL4B CUL4A	3.61e-05	4	86	2	19818632
Pubmed	Cloning and characterization of mouse ACF7, a novel member of the dystonin subfamily of actin binding proteins.	DST DMD	3.61e-05	4	86	2	8954775
Pubmed	A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.	CYP2A6 CYP2A7	3.61e-05	4	86	2	7565685
Pubmed	Nonerythroid alphaII spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links.	ERCC4 SPTAN1	3.61e-05	4	86	2	12571280
Pubmed	Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.	CUL4B CUL4A	3.61e-05	4	86	2	22453236
Pubmed	Quantitative analysis of FMO gene mRNA levels in human tissues.	FMO2 FMO5	3.61e-05	4	86	2	16183778
Pubmed	The molecular biology of the flavin-containing monooxygenases of man.	FMO2 FMO5	3.61e-05	4	86	2	7720101
Pubmed	Cullin 4B is recruited to tristetraprolin-containing messenger ribonucleoproteins and regulates TNF-α mRNA polysome loading.	CUL4B CUL4A	3.61e-05	4	86	2	22262661
Pubmed	SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.	CUL4B ERCC4 TRIM25 PES1 CHD2	3.67e-05	150	86	5	30154076
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	GLMN TRIM25 WDR75 COPA COX4I1 SPTAN1 PRIM1 TBK1 PES1 RPS8 CARS1 CHD1 SF3B2	4.67e-05	1425	86	13	30948266
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	ZNF675 PHEX CYP2A6 DST WDR75 COPA PYROXD1 SPTAN1 PES1 GPC4 CHD2 DMD MYBPC2	5.27e-05	1442	86	13	35575683
Pubmed	CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy.	CUL4B CUL4A	6.01e-05	5	86	2	32466489
Pubmed	The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression.	FMO2 FMO5	6.01e-05	5	86	2	8128486
Pubmed	Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine.	FMO2 FMO5	6.01e-05	5	86	2	32156684
Pubmed	Distinctive serum miRNA profile in mouse models of striated muscular pathologies.	DMD MYBPC3	6.01e-05	5	86	2	23418438
Pubmed	Cullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complex.	CUL4B CUL4A	6.01e-05	5	86	2	24719410
Pubmed	The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.	CUL4B CUL4A	6.01e-05	5	86	2	22118460
Pubmed	Isoform transitions of the myosin binding protein C family in developing human and mouse muscles: lack of isoform transcomplementation in cardiac muscle.	MYBPC2 MYBPC3	6.01e-05	5	86	2	9440711
Pubmed	Cullin 4A and 4B ubiquitin ligases interact with γ-tubulin and induce its polyubiquitination.	CUL4B CUL4A	6.01e-05	5	86	2	25542213
Pubmed	Human alpha spectrin II and the FANCA, FANCC, and FANCG proteins bind to DNA containing psoralen interstrand cross-links.	ERCC4 SPTAN1	6.01e-05	5	86	2	11401546
Pubmed	Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival.	CUL4B CUL4A	6.01e-05	5	86	2	27142104
Pubmed	Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.	CUL4B CUL4A	6.01e-05	5	86	2	26711351
Pubmed	SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response.	TRIM25 TBK1	6.01e-05	5	86	2	33801464
Pubmed	Kinetics of cardiac muscle contraction and relaxation are linked and determined by properties of the cardiac sarcomere.	DMD MYBPC3	6.01e-05	5	86	2	20656885
Pubmed	A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities.	FMO2 FMO5	6.01e-05	5	86	2	8311461
Pubmed	Molecular double clips within RepID WD40 domain control chromatin binding and CRL4-substrate assembly.	CUL4B CUL4A	6.01e-05	5	86	2	34171797
Pubmed	Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation.	CUL4B CUL4A	6.01e-05	5	86	2	36056023
Pubmed	Selective degradation of splicing factor CAPERα by anticancer sulfonamides.	CUL4B CUL4A	6.01e-05	5	86	2	28437394
Pubmed	The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels.	CUL4B CUL4A	6.01e-05	5	86	2	26021757
Pubmed	Regulation of liver receptor homologue-1 by DDB2 E3 ligase activity is critical for hepatic glucose metabolism.	CUL4B CUL4A	6.01e-05	5	86	2	30923324
Pubmed	The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II.	CUL4B CUL4A CDK7	6.24e-05	31	86	3	32355176
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	DLG5 TRIM25 DST VPS72 WDR75 COX4I1 PES1 ANKRD11 CHD1 CHD2 DAAM1 RABL3 CDK7	7.70e-05	1497	86	13	31527615
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	ZNF675 RAB23 LOXHD1 DST TBK1 RNF213 CHD2 PWWP3B DNAH14	8.73e-05	736	86	9	29676528
Pubmed	Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint.	CUL4B CUL4A	9.01e-05	6	86	2	14578910
Pubmed	cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.	CUL4B CUL4A	9.01e-05	6	86	2	8681378
Interaction	GAN interactions	GLMN DLG5 DST SPTAN1 RTTN RPS8 KBTBD8 RNF213 DMD	1.33e-06	253	86	9	int:GAN
Interaction	DNAJC8 interactions	WDR75 TBK1 PES1 RPS8 ANKRD11 CHD1 SF3B2 PPP4R3A	6.29e-06	230	86	8	int:DNAJC8
Interaction	SNRPB interactions	CUL4B CUL4A TRIM25 TBRG1 COPA SUGP1 PPWD1 CWF19L1 SF3B2 IL7R PPP4R3A	1.23e-05	517	86	11	int:SNRPB
GeneFamily	Fibronectin type III domain containing\|I-set domain containing\|Myosin binding proteins	MYBPC2 MYBPC3	2.25e-04	8	52	2	658
GeneFamily	Cullins	CUL4B CUL4A	2.25e-04	8	52	2	1032
GeneFamily	Fibronectin type III domain containing	PTPRJ IL7R MYBPC2 MYBPC3	1.15e-03	160	52	4	555
Coexpression	CHEN_HOXA5_TARGETS_9HR_UP	RCAN1 PYROXD1 TBK1 CARS1 DAAM1 PPWD1 FAM13B CDK7	7.27e-07	223	86	8	M17621
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	PACS1 TBRG1 PTPRJ SPTAN1 TBK1 GRAMD1A TBC1D2B ANKRD11 RNF213 CHD1 CHD2 ACAP2 ITGB2 FAM13B CDC14A IL7R PPP4R3A	5.94e-06	1492	86	17	M40023
Coexpression	GSE3982_NEUTROPHIL_VS_TH1_UP	CUL4B SEMA4A ACAP2 ITGB2 CDC14A SNX13	4.77e-05	197	86	6	M5532
Coexpression	GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN	FMO5 TRIM25 GRAMD1A CHD2 DMD ATAT1	4.90e-05	198	86	6	M7480
Coexpression	GSE28726_NAIVE_VS_ACTIVATED_CD4_TCELL_UP	MAPRE3 DLG5 SPTAN1 RPS8 CDC14A IL7R	5.18e-05	200	86	6	M8320
Coexpression	GSE41978_ID2_KO_VS_ID2_KO_AND_BIM_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_UP	MAPRE3 MLH3 VPS72 PTPRJ RIOK3 SEMA4A	5.18e-05	200	86	6	M9555
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_UP	CUL4B WDR75 CSNK1G3 PRIM1 ANKRD11 RIOK3 PWWP3B PPWD1 FAM13B	5.51e-05	523	86	9	M12707
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_UP	CUL4B WDR75 CSNK1G3 PRIM1 ANKRD11 RIOK3 PWWP3B PPWD1 FAM13B	6.47e-05	534	86	9	MM1054
Coexpression	NAKAYA_PBMC_FLUMIST_AGE_18_50YO_3DY_DN	CUL4A TBRG1 CSNK1G3 SPTAN1 CHD1 CHD2 CWF19L1 PPP4R3A SNX13 CDK7	7.77e-05	680	86	10	M41089
Coexpression	GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_GREEN_UP	RAB23 RCAN1 CHD2	8.40e-05	26	86	3	M5968
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	RNF213 CHD1 CHD2 ANKRD12 CDC14A IL7R	1.01e-06	171	86	6	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	SPTAN1 RNF213 CHD2 ANKRD12 CDC14A IL7R	1.40e-06	181	86	6	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	ANKRD11 RNF213 CHD1 CHD2 ANKRD12 CDC14A	1.75e-06	188	86	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	RNF213 CHD1 CHD2 ANKRD12 CDC14A IL7R	1.98e-06	192	86	6	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Deptor_(Deep_layer_pyramidal_cells--Layer_5a)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	PHEX LOXHD1 DEPTOR IRGC MYBPC3	2.17e-06	108	86	5	514dfc3f7ac303311ae599f981f3f3c7eb6801b8
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RTTN ANKRD11 RNF213 CHD2 ANKRD12 CDC14A	2.43e-06	199	86	6	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DST SPTAN1 RNF213 DOCK6 FAM13B IL7R	2.50e-06	200	86	6	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1D MAPRE3 PTPRJ ADGRF1 FYB2	1.08e-05	150	86	5	87968ce885a4959616f0321f58517fe8029ba1b1
ToppCell	lung-Club_Cells\|lung / shred on tissue and cell subclass	FMO2 DST PRIM1 FUOM ITGB2	1.66e-05	164	86	5	b12cacd499b18b96120ca6d14646aebeaed41d10
ToppCell	facs-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAJC13 FMO5 PAH GPC4 AADAT	1.92e-05	169	86	5	ee27bcfe3f9a295ec5fb0a375d77d1050e5cbaad
ToppCell	facs-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAJC13 FMO5 PAH GPC4 AADAT	1.92e-05	169	86	5	922086f218135b734b7d370b871923e50141edce
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAPRE3 LOXHD1 PTPRJ ADGRF1 FYB2	2.27e-05	175	86	5	77c16e615c0fb9c83f29d7e0a547be72635fac81
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAPRE3 LOXHD1 PTPRJ ADGRF1 FYB2	2.27e-05	175	86	5	98947a226b5a2ac7091ff9d34243ea7736add973
ToppCell	pdx-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	CACNA1D FMO5 PAH DMD FYB2	2.33e-05	176	86	5	1e21f80cf0e695ffdd63e4a72cf1e3fa41b60341
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAPRE3 LOXHD1 PTPRJ ADGRF1 FYB2	2.33e-05	176	86	5	c2c4306476989bc2fb30dab00250ef7915842f13
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	DNAJC13 MLH3 TRIM25 DST RNF213	2.40e-05	177	86	5	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	PACS1 DST DEPTOR CDC14A IL7R	2.89e-05	184	86	5	d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCell	droplet-Bladder-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMO5 RCAN1 ANKRD11 CHD1 ANKRD12	3.12e-05	187	86	5	663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SPTAN1 GRAMD1A PPWD1 CDC14A IL7R	3.36e-05	190	86	5	91ba66d4b56c59523485b17738e93f14bb00afa4
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	CSNK1G3 RPS8 CHD1 CHD2 IL7R	3.54e-05	192	86	5	aee6522d25e012231cdb905ce047295cb64d6e82
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-Secretory/RAS-RAS\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYP2A6 CYP2A7 FMO2 RPS8 PWWP3B	3.62e-05	193	86	5	525e0de0f25f3308daf49e7d4c8774562f1f40ad
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-Secretory/RAS\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CYP2A6 CYP2A7 FMO2 RPS8 PWWP3B	3.62e-05	193	86	5	2d18f39615043dfbff120a00f6540ffa93082c83
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DEPTOR PTPRJ GPC4 RNF213 ADGRF1	3.71e-05	194	86	5	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	COVID_non-vent-Lymphocytic-T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	SPTAN1 CHD2 ANKRD12 CDC14A IL7R	3.81e-05	195	86	5	4bdedd924564a260841a9153604026b57487c83d
ToppCell	COVID_non-vent-Lymphocytic-T_cell-CD4+_Memory_T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	DST SPTAN1 ANKRD12 CDC14A IL7R	3.81e-05	195	86	5	22191d361af136942508f1553ff41a626ed982ad
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD4+_T-CD4+_Tcm-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SPTAN1 RPS8 ANKRD12 CDC14A IL7R	3.90e-05	196	86	5	d4fd5513e98eec092d51199e7f054bc15a5eaa3d
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD4+_T-CD4+_Tcm-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPTAN1 RPS8 ANKRD12 CDC14A IL7R	3.90e-05	196	86	5	3a08209210e1a8677097a78786e00062c81b1ad2
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD4+_T-CD4+_Tcm\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPTAN1 RPS8 ANKRD12 CDC14A IL7R	3.90e-05	196	86	5	fddc3e89e7e6b093563655c2d02e86836cfd6da5
ToppCell	COVID-19_Convalescent-CD4+_Tcm\|COVID-19_Convalescent / Disease condition and Cell class	SPTAN1 RPS8 ANKRD12 CDC14A IL7R	3.90e-05	196	86	5	f2a5eeb1cebde2762865ab29792370b751214c4d
ToppCell	COVID-19_Convalescent-Lymphoid_T/NK-CD4+_Tcm\|COVID-19_Convalescent / Disease group, lineage and cell class	SPTAN1 RPS8 ANKRD12 CDC14A IL7R	3.90e-05	196	86	5	8caf4334ae692ce44e8fea5d606416afc5b72c00
ToppCell	remission-CD4+_Tcm\|remission / disease stage, cell group and cell class	SPTAN1 RPS8 ANKRD12 CDC14A IL7R	3.90e-05	196	86	5	db7a9669ae35e2c6b465941afef9f7a6b1e7190e
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-CD4+_T-CD4+_Tcm\|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)	SPTAN1 RPS8 ANKRD12 CDC14A IL7R	3.90e-05	196	86	5	7d841113a7161b017a08602d46366ac044271b34
ToppCell	COVID_vent-Lymphocytic-T_cell-CD4+_Memory_T_cell\|COVID_vent / Disease condition, Lineage, Cell class and subclass	SPTAN1 RPS8 ANKRD12 CDC14A IL7R	4.09e-05	198	86	5	58f208b76cb0adcecdf632d92f92833a06f9bf71
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_2\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	FMO2 IRGC ADGRF1 ITGB2	4.24e-05	100	86	4	b4e8f3cbb5023d2227f43e683967ec2f848648f1
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DST SPTAN1 RNF213 DOCK6 IL7R	4.29e-05	200	86	5	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DST SPTAN1 RNF213 DOCK6 IL7R	4.29e-05	200	86	5	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ANKRD11 RNF213 CHD1 CHD2 ANKRD12	4.29e-05	200	86	5	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Mild / Disease, condition lineage and cell class	DST SPTAN1 RNF213 CDC14A IL7R	4.29e-05	200	86	5	d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	ANKRD11 RNF213 RIOK3 CHD1 ANKRD12	4.29e-05	200	86	5	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	COVID-19-COVID-19_Convalescent-Lymphocyte-T/NK-CD4+_Tcm\|COVID-19_Convalescent / Disease, condition lineage and cell class	SPTAN1 RPS8 ANKRD12 CDC14A IL7R	4.29e-05	200	86	5	99c5abfe96d791c60ae6021ab4201851ee4afc47
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-FB-3\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	PHEX PRPF40B DMD FUOM	1.44e-04	137	86	4	25b5370b63644351efddb8749ef174beca0581cd
ToppCell	PND07-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LOXHD1 CAMP SEMA4A MYBPC3	1.56e-04	140	86	4	90298cac4bcec614a48e60b5c139c86daa9f0321
ToppCell	PND07-Immune-Immune_Myeloid-Granulocytic-Neutrophil\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LOXHD1 CAMP SEMA4A MYBPC3	1.56e-04	140	86	4	671ab1f5cbd8568bf93ebdf961c2a1ede06d2bcb
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	WDR75 SEMA4A DNAH14 IL7R	1.84e-04	146	86	4	1bf67a9416f52198931b912a31be4bab09fefd19
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	CHD2 ANKRD12 CDC14A IL7R	2.09e-04	151	86	4	999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	WDR75 SEMA4A DNAH14 IL7R	2.14e-04	152	86	4	b8aa62e3cf2b4c252db4bccfa75d881c4fa0a788
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	RNF213 CHD1 ANKRD12 CDC14A	2.37e-04	156	86	4	1545169694f686d28648a68b552c2ae606599d66
ToppCell	facs-Heart-RA-24m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAMP ADGRF1 MYBPC2 MYBPC3	2.43e-04	157	86	4	9021900d9b1a71210c9c414a9d165eaf399eb607
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAPRE3 PTPRJ ADGRF1 FYB2	2.43e-04	157	86	4	c17c5c01fcb65c453690c265ec4f300ecdfefd34
ToppCell	facs-Heart-RA-24m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAMP ADGRF1 MYBPC2 MYBPC3	2.43e-04	157	86	4	c8c627ca181856cd31dba4cf073c2be659a49dc1
ToppCell	390C-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	GLMN MLH3 PTPRJ IL7R	2.73e-04	162	86	4	45be019b50e3727fc9d3fad2ff78e74e4f2d746b
ToppCell	390C-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	GLMN MLH3 PTPRJ IL7R	2.73e-04	162	86	4	fbb0cc2b1434a340dc35058b77c73ea61004c252
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	CHD2 ANKRD12 CDC14A IL7R	2.73e-04	162	86	4	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-Enterocyte_(Proximal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAPRE3 FMO5 CIDEC FYB2	2.93e-04	165	86	4	ce79d217df88035457cd58f679e72dd98722ae22
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-Enterocyte_(Proximal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAPRE3 FMO5 CIDEC FYB2	3.00e-04	166	86	4	22b31acbbef1936ce19b393cf880c63ea2fa0f1b
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-DN4\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRAMD1A SEMA4A ITGB2 IL7R	3.07e-04	167	86	4	10c9fab3573c2948081aac2cec1798e46e59e38a
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CARS1 AADAT CDC14A IL7R	3.07e-04	167	86	4	4b6853efefea5178280ba7c31facda0fbd1cc469
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	WDR75 PPWD1 CDC14A IL7R	3.07e-04	167	86	4	ced6ed9b412739c6ced622523347c10295edbf53
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-8\|TCGA-Thryoid / Sample_Type by Project: Shred V9	CHST10 SPTAN1 DMD CDC14A	3.14e-04	168	86	4	00646601548b0fee42ae16bfa5e93603bc7c5129
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CIDEC RTTN KBTBD8 ITGB2	3.14e-04	168	86	4	a1755afa2cc50960ba60e07d84d61be429cdea72
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHST10 CSNK1G3 IRGC PPWD1	3.14e-04	168	86	4	784ce773521e5d74570f45120e56d112bc76ff49
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRAMD1A SEMA4A ITGB2 IL7R	3.21e-04	169	86	4	2de213b083f57f47be58427c0ce127fee9f85caa
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAPRE3 PTPRJ ADGRF1 FYB2	3.21e-04	169	86	4	2a21f2cef959526bfe3c8f081f4f7e9dd4e01a37
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRAMD1A SEMA4A ITGB2 IL7R	3.28e-04	170	86	4	90f7640f04672c800cb28aea50004b1bb0565e8a
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHST10 CSNK1G3 IRGC PPWD1	3.28e-04	170	86	4	7a4ed69c807c3761210776e8fe6680d1bd892e82
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Enterocyte_(Proximal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAPRE3 FMO5 CIDEC FYB2	3.36e-04	171	86	4	5d0d6c1ff610a703ae0b834a12823c5ff9012932
ToppCell	droplet-Thymus-nan-18m-Lymphocytic-DN4\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRAMD1A SEMA4A ITGB2 IL7R	3.36e-04	171	86	4	f08402d0f42822c35673522043b652f8fb68d2f6
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-DN4\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS8 SEMA4A ITGB2 IL7R	3.43e-04	172	86	4	d098e8a9c7666354803225cf2650faad436bab66
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAPRE3 PTPRJ ADGRF1 FYB2	3.51e-04	173	86	4	0bc2aacae60c6d3276b0949eb0748b4ac1f56e54
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RPS8 SEMA4A ITGB2 IL7R	3.58e-04	174	86	4	319bfafc66a21ad05ab35e0fd024c8b372a07165
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAPRE3 PTPRJ ADGRF1 FYB2	3.58e-04	174	86	4	5f4436863a40f8bca46e2989bca66c02b6be88d4
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PAH PWWP3B SEMA4A DNAH14	3.58e-04	174	86	4	2947e5906b172d149412fa4e77476fce4ea695d2
ToppCell	Healthy_donor-Treg\|World / disease group, cell group and cell class (v2)	SPTAN1 ANKRD12 CDC14A IL7R	3.58e-04	174	86	4	dc3b06420b0ad9c7060571e7bf5714e028d598bf
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST PTPRJ IP6K1 SNX13	3.66e-04	175	86	4	1ea6cf9da26601646f57fa14d558a5e9e1f0b345
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAPRE3 LOXHD1 ADGRF1 FYB2	3.74e-04	176	86	4	25ebc8716aa44e44fce577701e3e82c6745a75ab
ToppCell	PND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PHEX CACNA1D FMO2 PRIM1	3.74e-04	176	86	4	cb8fd56a4f935cdda19d7ab43382cdda7c307667
ToppCell	CV-Severe-7\|CV / Virus stimulation, Condition and Cluster	MLH3 TRIM25 DST RNF213	3.74e-04	176	86	4	3de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCell	facs-Spleen-nan-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D2B SEMA4A ITGB2 IL7R	3.82e-04	177	86	4	0d894a14ddbb2734557743e9efdb89cee5c26769
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAPRE3 PTPRJ ADGRF1 FYB2	3.82e-04	177	86	4	8e4005fad50e6f919da175f3b9ae58849dbd60b1
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ERCC4 CIDEC PRIM1 SEMA4A	3.82e-04	177	86	4	1d5a071157c755f3a27a5c3143015da04ee0b0dc
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CIDEC KBTBD8 SEMA4A ITGB2	3.82e-04	177	86	4	67cc3a6461db5e0678f96b18224aeb83ad34b0f4
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	DST SPTAN1 CHD2 ANKRD12	3.82e-04	177	86	4	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAPRE3 PTPRJ ADGRF1 FYB2	3.82e-04	177	86	4	f35b04c3557ebbdeba37dec54c8f45880eafb422
ToppCell	PBMC-Severe-cDC_11\|Severe / Compartment, Disease Groups and Clusters	CIDEC KCNN3 DMD MYBPC2	3.91e-04	178	86	4	0667abc05eb2254710b9c648c65b7cfdfe7831b7
ToppCell	normal_Lymph_Node-B_lymphocytes-GC_B_cells_in_the_LZ\|normal_Lymph_Node / Location, Cell class and cell subclass	CAMP KCNN3 DAAM1 SEMA4A	3.91e-04	178	86	4	d75057e7463558a0d3cebde3c30befbf4704dd9a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAPRE3 LOXHD1 ADGRF1 FYB2	3.99e-04	179	86	4	e6ae070b4c52ba08167c7d64ea4cfbac0454c1bf
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TBC1D2B APOL3 PPWD1 CDC14A	4.16e-04	181	86	4	986c036e656f24fe374807e2711cec9e3c83c892
ToppCell	COVID-19-T_cells-Tregs\|COVID-19 / group, cell type (main and fine annotations)	PACS1 PTPRJ CDC14A IL7R	4.16e-04	181	86	4	534659cf754326c6a73c0daa30e9d610612a0292
ToppCell	facs-Marrow-T-cells-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPC4 ITGB2 FYB2 IL7R	4.16e-04	181	86	4	7286700396676fdc41d9723979b8b408177aceb9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAPRE3 PTPRJ ADGRF1 FYB2	4.16e-04	181	86	4	30729f0364f719c044712a51453e22dc2c1a232b
ToppCell	367C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	RPS8 PAH CDC14A IL7R	4.16e-04	181	86	4	9b155a74e68e485039a5195144a12833f2f75058
ToppCell	ASK454-Epithelial\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	FMO2 DST SPTAN1 AADAT	4.25e-04	182	86	4	ab15316cff989b61ff397a866d7ca8b49c13e981
ToppCell	LPS_only-Myeloid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTPRJ CAMP SEMA4A ITGB2	4.25e-04	182	86	4	666ac86ee5f6fa9241ae8d80340743707e54b278
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-innate_lymphocytic-innate_lymphoid_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DST DEPTOR CDC14A IL7R	4.25e-04	182	86	4	b86690c109cdc16844a6cd2216c1bf2bf28efd45
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	TRIM25 DST RNF213 CHD2	4.34e-04	183	86	4	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	DST DMD FYB2 MYBPC3	4.43e-04	184	86	4	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D122\|Adult / Lineage, Cell type, age group and donor	FMO2 DST DMD FYB2	4.43e-04	184	86	4	561592edc3083fad41b91811151b442207c65dd9
ToppCell	droplet-Spleen-SPLEEN-1m-Lymphocytic-mature_NK_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRAMD1A SEMA4A ITGB2 IL7R	4.43e-04	184	86	4	8095be57ed189763b5be039f330149a41e5b406a
ToppCell	remission-CD8+_T_naive\|World / disease stage, cell group and cell class	RGSL1 RPS8 CARS1 IL7R	4.52e-04	185	86	4	69304d7dd406ac7e96d51c239d7035a06d88704f
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIM25 DST CIDEC KCNN3	4.52e-04	185	86	4	afbb88325e4a81c15ac1d0a004e3e1f4ba2ee87b
Drug	Ketotifen fumarate [34580-14-8]; Up 200; 9.4uM; MCF7; HT_HG-U133A	ZNF675 ERCC4 COPA RCAN1 SPTAN1 GPC4 SEMA4A CDC14A PPP4R3A	5.86e-08	197	86	9	7199_UP
Drug	Medrysone [2668-66-8]; Up 200; 11.6uM; MCF7; HT_HG-U133A	PHEX PACS1 MAPRE3 DLG5 COPA RCAN1 SUGP1 CDC14A	9.10e-07	200	86	8	3403_UP
Drug	Estradiol-17 beta [50-28-2]; Up 200; 14.6uM; HL60; HT_HG-U133A	CUL4B ZNF675 RAB23 MLH3 COPA CDC14A PPP4R3A	7.25e-06	188	86	7	1299_UP
Drug	Prochlorperazine dimaleate [84-02-6]; Up 200; 6.6uM; HL60; HT_HG-U133A	CUL4B ZNF675 RAB23 COPA RCAN1 SUGP1 PPP4R3A	7.77e-06	190	86	7	1286_UP
Drug	aspirin, USP; Down 200; 100uM; HL60; HT_HG-U133A	RAB23 ERCC4 COPA RCAN1 SUGP1 ANKRD12 SNX13	8.32e-06	192	86	7	6164_DN
Drug	Cefixime [79350-37-1]; Down 200; 8.8uM; MCF7; HT_HG-U133A	CUL4B TRIM25 COPA RCAN1 SUGP1 ANKRD12 CWF19L1	9.84e-06	197	86	7	3247_DN
Drug	Todralazine hydrochloride [3778-76-5]; Up 200; 14.8uM; MCF7; HT_HG-U133A	CHST10 COPA RCAN1 SPTAN1 CDC14A PPP4R3A SNX13	9.84e-06	197	86	7	1677_UP
Drug	Buspirone hydrochloride [33386-08-2]; Up 200; 9.4uM; HL60; HT_HG-U133A	ZNF675 RAB23 ERCC4 COPA RCAN1 SUGP1 ANKRD12	9.84e-06	197	86	7	1282_UP
Drug	Sulfamethizole [144-82-1]; Up 200; 14.8uM; MCF7; HT_HG-U133A	ZNF675 PACS1 RCAN1 SUGP1 ANKRD12 SEMA4A CDC14A	1.05e-05	199	86	7	6272_UP
Drug	Nimodipine [66085-59-4]; Down 200; 9.6uM; MCF7; HT_HG-U133A	CUL4B PHEX RAB23 CACNA1D CIDEC SUGP1 CWF19L1	1.05e-05	199	86	7	6480_DN
Drug	Azacyclonol [115-46-8]; Down 200; 15uM; PC3; HT_HG-U133A	CUL4B ZNF675 RAB23 PACS1 FMO5 RCAN1 CDC14A	1.09e-05	200	86	7	6298_DN
Drug	2'-methoxyacetophenone	CYP2A6 CYP2A7	4.22e-05	3	86	2	CID000068481
Drug	LY 294002; Up 200; 10uM; MCF7; HT_HG-U133A_EA	CUL4B ZNF675 RAB23 DEPTOR TBC1D2B SUGP1	7.06e-05	184	86	6	1007_UP
Drug	ranitidine N-oxide	FMO2 FMO5	8.42e-05	4	86	2	CID003033888
Drug	Dorzolamide hydrochloride [130693-82-2]; Down 200; 11uM; HL60; HT_HG-U133A	ERCC4 TRIM25 COPA SUGP1 RIOK3 CWF19L1	8.68e-05	191	86	6	6142_DN
Drug	Meclozine dihydrochloride [1104-22-9]; Down 200; 8.6uM; MCF7; HT_HG-U133A	PHEX ERCC4 COPA RCAN1 TBC1D2B SUGP1	9.19e-05	193	86	6	3285_DN
Drug	SR-95639A [115767-94-7]; Up 200; 10uM; HL60; HT_HG-U133A	CUL4B ZNF675 DNAJC13 COPA RCAN1 SPTAN1	9.19e-05	193	86	6	1336_UP
Drug	Prednisolone [50-24-8]; Down 200; 11uM; PC3; HT_HG-U133A	ZNF675 PACS1 FMO5 TRIM25 DEPTOR SNX13	9.19e-05	193	86	6	5101_DN
Drug	estradiol, USP; Up 200; 0.01uM; MCF7; HT_HG-U133A_EA	RAB23 TRIM25 DEPTOR SUGP1 ACAP2 SNX13	9.19e-05	193	86	6	1079_UP
Drug	Griseofulvin [126-07-8]; Down 200; 11.2uM; MCF7; HT_HG-U133A	CACNA1D DNAJC13 ERCC4 TRIM25 TBC1D2B CDC14A	9.46e-05	194	86	6	2293_DN
Drug	Androsterone [53-41-8]; Down 200; 13.8uM; MCF7; HT_HG-U133A	PACS1 DLG5 MLH3 SPTAN1 SUGP1 SEMA4A	9.46e-05	194	86	6	5696_DN
Drug	Mecamylamine hydrochloride [826-39-1]; Down 200; 19.6uM; MCF7; HT_HG-U133A	PACS1 CHST10 ERCC4 TRIM25 SPTAN1 GPC4	9.73e-05	195	86	6	3525_DN
Drug	Myosmine [532-12-7]; Down 200; 27.4uM; HL60; HT_HG-U133A	CUL4B FMO5 COPA RCAN1 CWF19L1 SNX13	9.73e-05	195	86	6	2199_DN
Drug	PF-00562151-00 [351320-12-2]; Down 200; 10uM; MCF7; HT_HG-U133A	RAB23 CACNA1D ERCC4 COPA SPTAN1 SUGP1	9.73e-05	195	86	6	6868_DN
Drug	Iressa; Up 200; 10uM; HL60; HG-U133A	CHST10 CIDEC GPC4 CARS1 ANKRD11 SEMA4A	9.73e-05	195	86	6	541_UP
Drug	Allantoin [97-59-6]; Down 200; 25.2uM; PC3; HT_HG-U133A	ZNF675 PACS1 COPA RCAN1 SPTAN1 ADGRF1	1.00e-04	196	86	6	5052_DN
Drug	Perhexiline maleate [6724-53-4]; Down 200; 10.2uM; PC3; HT_HG-U133A	ZNF675 FMO5 CIDEC SUGP1 DOCK6 ADGRF1	1.00e-04	196	86	6	5081_DN
Drug	Pregnenolone [145-13-1]; Up 200; 12.6uM; MCF7; HT_HG-U133A	ZNF675 RAB23 ERCC4 CDC14A CWF19L1 SNX13	1.03e-04	197	86	6	4802_UP
Drug	Nicardipine hydrochloride [54527-84-3]; Down 200; 7.8uM; MCF7; HT_HG-U133A	CUL4B ZNF675 RAB23 ERCC4 SUGP1 CDC14A	1.03e-04	197	86	6	3215_DN
Drug	Benzamil hydrochloride [2898-76-2]; Down 200; 11.2uM; HL60; HT_HG-U133A	CHST10 TRIM25 CIDEC SPTAN1 SUGP1 DOCK6	1.06e-04	198	86	6	2200_DN
Drug	Ornidazole [16773-42-5]; Down 200; 18.2uM; MCF7; HT_HG-U133A	DLG5 ERCC4 FMO5 TRIM25 SUGP1 CDC14A	1.06e-04	198	86	6	2272_DN
Drug	Cefotiam hydrochloride; Up 200; 7.2uM; MCF7; HT_HG-U133A	ERCC4 TBC1D2B SEMA4A DOCK6 CDC14A PPP4R3A	1.06e-04	198	86	6	5361_UP
Drug	Hydroquinine hydrobromide hydrate [304695-81-6]; Up 200; 9.4uM; MCF7; HT_HG-U133A	RCAN1 SPTAN1 GPC4 SUGP1 SEMA4A ACAP2	1.06e-04	198	86	6	6263_UP
Drug	Scopolamin-N-oxide hydrobromide [6106-81-6]; Up 200; 10uM; PC3; HT_HG-U133A	PHEX PACS1 MAPRE3 TRIM25 TBC1D2B GPC4	1.06e-04	198	86	6	2099_UP
Drug	Triflusal [322-79-2]; Up 200; 16.2uM; MCF7; HT_HG-U133A	CACNA1D MAPRE3 RCAN1 TBC1D2B SEMA4A SNX13	1.06e-04	198	86	6	7451_UP
Drug	Enalapril maleate [76095-16-4]; Up 200; 8.2uM; MCF7; HT_HG-U133A	CUL4B PACS1 MAPRE3 ANKRD12 DOCK6 CWF19L1	1.06e-04	198	86	6	7428_UP
Drug	Ketoconazole [65277-42-1]; Down 200; 7.6uM; MCF7; HT_HG-U133A	ZNF675 PHEX TRIM25 CIDEC DOCK6 CDC14A	1.06e-04	198	86	6	2640_DN
Drug	Carteolol hydrochloride [51781-21-6]; Down 200; 12.2uM; HL60; HT_HG-U133A	ZNF675 FMO5 COPA RCAN1 SUGP1 CWF19L1	1.06e-04	198	86	6	1340_DN
Drug	Sulfanilamide [63-74-1]; Down 200; 23.2uM; MCF7; HT_HG-U133A	CHST10 DLG5 ERCC4 FMO5 TBC1D2B SEMA4A	1.09e-04	199	86	6	6810_DN
Drug	Alfuzosin hydrochloride [81403-68-1]; Down 200; 9.4uM; HL60; HG-U133A	CUL4A CIDEC PES1 TBC1D2B SUGP1 SF3B2	1.09e-04	199	86	6	1586_DN
Drug	Ceftazidime pentahydrate [78439-06-2]; Down 200; 6.2uM; PC3; HT_HG-U133A	PACS1 MAPRE3 MLH3 CIDEC SUGP1 DOCK6	1.09e-04	199	86	6	5054_DN
Drug	Z-103	PHEX DMD	1.40e-04	5	86	2	CID006918055
Drug	Ccris 2188	FMO2 FMO5	1.40e-04	5	86	2	CID000146896
Drug	T-I-Q	FMO2 FMO5 PAH	1.59e-04	28	86	3	CID000039062
Disease	serum albumin measurement	CYP2A6 CYP2A7 DNAJC13 PTPRJ CSNK1G3 GRAMD1A TBC1D2B KCNN3 IP6K1 IL7R SNX13 MYBPC3	1.32e-07	592	85	12	EFO_0004535
Disease	Hereditary Non-Polyposis Colon Cancer Type 2	MLH3 PTPRJ SEMA4A	2.16e-05	19	85	3	C1333991
Disease	Colorectal cancer, hereditary nonpolyposis, type 1	MLH3 PTPRJ SEMA4A	2.16e-05	19	85	3	C2936783
Disease	neutrophil count	CUL4A MAPRE3 DNAJC13 VPS72 COPA PTPRJ COX4I1 ANKRD11 KCNN3 RIOK3 SEMA4A DOCK6 CDC14A SNX13	3.85e-05	1382	85	14	EFO_0004833
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	MLH3 PTPRJ SEMA4A	5.72e-05	26	85	3	C0009405
Disease	Hereditary non-polyposis colorectal cancer syndrome	MLH3 PTPRJ SEMA4A	6.42e-05	27	85	3	C1112155
Disease	Hereditary Nonpolyposis Colorectal Cancer	MLH3 PTPRJ SEMA4A	7.99e-05	29	85	3	C1333990
Disease	alkaline phosphatase measurement	PHEX CYP2A6 CYP2A7 DLG5 DNAJC13 PTPRJ APOL3 SUGP1 ATAT1 SNX13 MYBPC3	1.58e-04	1015	85	11	EFO_0004533
Disease	reticulocyte measurement	CUL4A PACS1 DEPTOR PTPRJ TBK1 GRAMD1A KBTBD8 RIOK3 IP6K1 ACAP2 SNX13	2.17e-04	1053	85	11	EFO_0010700
Disease	myeloid white cell count	GLMN DLG5 DNAJC13 VPS72 PTPRJ GRAMD1A RIOK3 CDC14A IL7R SNX13	3.61e-04	937	85	10	EFO_0007988
Disease	thrombin generation potential measurement	PTPRJ MYBPC3	4.44e-04	11	85	2	EFO_0005538
Disease	nicotine metabolite ratio	CYP2A6 CYP2A7	5.31e-04	12	85	2	EFO_0007794
Disease	aspartate aminotransferase measurement	CYP2A6 DLG5 DNAJC13 PTPRJ APOL3 SUGP1 RNF213 SNX13 MYBPC3	1.18e-03	904	85	9	EFO_0004736
Disease	caffeine metabolite measurement	CYP2A6 CYP2A7	1.36e-03	19	85	2	EFO_0007872
Disease	Deaf Mutism	CACNA1D CDC14A	1.51e-03	20	85	2	C4082305
Disease	Deafness, Acquired	CACNA1D CDC14A	1.51e-03	20	85	2	C0751068
Disease	Hearing Loss, Extreme	CACNA1D CDC14A	1.51e-03	20	85	2	C0086395
Disease	Complete Hearing Loss	CACNA1D CDC14A	1.51e-03	20	85	2	C0581883
Disease	Prelingual Deafness	CACNA1D CDC14A	1.51e-03	20	85	2	C0011052
Disease	Bilateral Deafness	CACNA1D CDC14A	1.51e-03	20	85	2	C3665473
Disease	Autism Spectrum Disorders	PAH ANKRD11 CHD2	1.92e-03	85	85	3	C1510586
Disease	creatinine measurement	GLMN DNAJC13 DEPTOR VPS72 PTPRJ APOL3 ANKRD11 CHD2 CDC14A	2.26e-03	995	85	9	EFO_0004518
Disease	Deafness	CACNA1D CDC14A	2.36e-03	25	85	2	C0011053
Disease	C-reactive protein measurement	CUL4A GLMN PACS1 CYP2A6 CYP2A7 DEPTOR KCNN3 SF3B2 IL7R MYBPC3	2.43e-03	1206	85	10	EFO_0004458
Disease	L lactate dehydrogenase measurement	PTPRJ SNX13	2.55e-03	26	85	2	EFO_0004808
Disease	sunburn	ERCC4 ANKRD11 KCNN3	2.72e-03	96	85	3	EFO_0003958
Disease	Colorectal cancer	MLH3 PTPRJ	2.75e-03	27	85	2	cv:C0346629
Disease	COLORECTAL CANCER	MLH3 PTPRJ	2.75e-03	27	85	2	114500
Disease	Neoplasm of the large intestine	MLH3 PTPRJ	2.75e-03	27	85	2	cv:C0009404
Disease	hypertension, COVID-19	CACNA1D PTPRJ	2.75e-03	27	85	2	EFO_0000537, MONDO_0100096

Protein segments in the cluster

Peptide	Gene	Start	Entry
ERKKEIYELARKYDF	AADAT	211	Q8N5Z0
REPFFRKKDRDYLDK	ANKRD11	901	Q6UB99
ARRVKKDTKFRDFFL	CYP2A6	371	P11509
YRDSKEKRDLRNFLK	ADGRF1	56	Q5T601
RLNKKIYEAKRFTDA	CDC14A	226	Q9UNH5
DFAKVLKNKFRTKRY	DMD	3371	P11532
AYIRAKYVERKFVDK	ACAP2	501	Q15057
YFEYLHIRKKIEEKR	ANKRD12	1836	Q6UB98
FSDAEIRRFIKSYKK	CHD1	1126	O14646
YKQRNEDFRKLFSKL	GRAMD1A	86	Q96CP6
KDITFQYFKSFKRVR	RCAN1	96	P53805
KRLKLRFYRTSVKED	RAB23	141	Q9ULC3
LSRFFDKVIEKRYFL	RABL3	196	Q5HYI8
LRFKRKIIGLKDEFY	PPP4R3A	556	Q6IN85
KKSKLIRVENFEAYF	PTPRJ	1016	Q12913
RYKKFDEFFKELLEN	GPC4	101	O75487
KRLEEFYSKLKEFSI	DST	5281	Q03001
KKLRKTLREFEEAFY	FAM13B	856	Q9NYF5
KRRRKKDIDFLALYE	LOXHD1	6	Q8IVV2
EKYKATLRRFFKSRG	CWF19L1	386	Q69YN2
FRRKELSETLDFKKD	KCNV1	156	Q6PIU1
LFEKRKRLSDYALIF	KCNN3	276	Q9UGI6
QKLREISFKYKEFEL	MLH3	221	Q9UHC1
EVVKKDYDALRKRYS	DLG5	311	Q8TDM6
RKLQEIYFIETKKFL	IL7R	86	P16871
YDYLRKLFTDLFDRK	CSNK1G3	301	Q9Y6M4
RLKKDEYEFFTHLDK	PAH	71	P00439
KKFYFVRTKVDEDLA	IRGC	161	Q6NXR0
LFYEDEDLRKVKKTR	PACS1	301	Q6VY07
ELGDRSKEYIRKKFL	KBTBD8	166	Q8NFY9
FIRKSINIIKKYFEE	PRIM1	211	P49642
DLREYRRFEKEKLKS	ITGB2	731	P05107
SLYFKKKFAERVAEV	DAAM1	776	Q9Y4D1
LAKIERFEFYERAKK	FUOM	111	A2VDF0
VREKKKISENFYFDL	DOCK6	286	Q96HP0
FTDAEIRRFIKAYKK	CHD2	1131	O14647
KSRAKRYEKLDFLGE	CDK7	6	P50613
ARRVKKDTKFRDFFL	CYP2A7	371	P20853
EFKFKLALINRKYDE	COPA	596	P53621
AKEFDLLKYIRFKTT	FMO5	96	P49326
KDVFEAFYKKDLAKR	CUL4A	446	Q13619
KEFKDVKLFYRFRKD	DEPTOR	106	Q8TB45
DKVSKETKKRRDFYE	FAM172A	231	Q8WUF8
KKRFTEEATKYFRER	APOL3	76	O95236
RFALLGDFFRKSKEK	CAMP	131	P49913
DESKIRKAYFRLAQK	DNAJC13	1316	O75165
FKLPKYRRLLETFFK	DNAH14	411	Q0VDD8
KERDFYFSKLRDIEL	MAPRE3	221	Q9UPY8
FIKVGYKKLFVLDDR	ATAT1	96	Q5SQI0
RSESKDRKLYKFLLL	IP6K1	196	Q92551
KLLEYFRIFAKKFDL	FMO2	86	Q99518
SRYLVDEIKKREGFK	GADL1	416	Q6ZQY3
DEKVELYRIKFKESF	COX4I1	76	P13073
EGKELEFYLRKIKAR	RPS8	191	P62241
LIQDYFRKFKKRKEQ	CACNA1D	1611	Q01668
DVFEAFYKKDLAKRL	CUL4B	601	Q13620
KDKEDSKRKVYFLIF	GLMN	76	Q92990
KRRVDEAYSLAKKTF	RTTN	2186	Q86VV8
DRDFLEKRKKDLNAY	SNX13	646	Q9Y5W8
LEFFREFLKERKAKI	RGSL1	656	A5PLK6
ILRRVLKDYFKFDVF	CARS1	76	P49589
ELFDAKIIYEKRRKA	PWWP3B	676	Q5H9M0
KLFRERFKYDKEIIV	FYB2	651	Q5VWT5
AKKRKVLEFERVYLD	PPWD1	61	Q96BP3
FSLLDIERVFKGKYK	SEMA4A	341	Q9H3S1
KKIDVARVTFDLYKL	CIDEC	136	Q96AQ7
KEYDAFIETIKKDRR	CLHC1	76	Q8NHS4
QKRLKTYFKFFIVRD	CHST10	176	O43529
IKDDFRFKDRFSKLN	RIOK3	306	O14730
FLYYRKKVAEIRKEA	SUGP1	231	Q8IWZ8
SLEKKDSYRKAIARF	RNF213	2696	Q63HN8
FKRIFEAFKLTDDVK	SF3B2	386	Q13435
KFREYKVFVRKLRKA	PES1	81	O00541
IYLQDEFRILKKKSF	PYROXD1	266	Q8WU10
SEEKELRKFRKIDYS	WDR75	811	Q8IWA0
FRKVEDLFLTFAKKA	SPTAN1	2086	Q13813
KRDEFEFLEKASKLR	TRIM25	301	Q14258
YFKDLFRILGSERKK	PHEX	346	P78562
LDLFKFYVEELKARF	PRPF40B	541	Q6NWY9
IKDSFEKVTLRRYEK	ZNF675	91	Q8TD23
FLLRLYRKTFEKDSK	ERCC4	431	Q92889
ATARAFKIIREAYKK	VPS72	311	Q15906
FRFALALFKYKEEEI	TBC1D2B	861	Q9UPU7
RLEEKFLKAKEERRY	TBRG1	61	Q3YBR2
EIYYQFKKDKAERRL	TBK1	561	Q9UHD2
FKKDKAERRLAYNEE	TBK1	566	Q9UHD2
TREDSFKARYRFKKD	MYBPC2	386	Q14324
VELTREETFKYRFKK	MYBPC3	491	Q14896