Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein tyrosine kinase activity	JAK2 MAP2K4 ABL1 EPHA6 PEAK1 TEK EPHA5	8.16e-08	145	51	7	GO:0004713
GeneOntologyMolecularFunction	insulin receptor substrate binding	JAK2 PTPN11 PIK3CA	6.99e-06	15	51	3	GO:0043560
GeneOntologyMolecularFunction	protein kinase activity	JAK2 MAP2K4 ABL1 EPHA6 PIK3CA PEAK1 TEK EPHA5	1.29e-04	600	51	8	GO:0004672
GeneOntologyMolecularFunction	non-membrane spanning protein tyrosine kinase activity	JAK2 ABL1 PEAK1	2.21e-04	46	51	3	GO:0004715
GeneOntologyMolecularFunction	delta-catenin binding	ABL1 PTPRT	3.47e-04	11	51	2	GO:0070097
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	JAK2 MAP2K4 ABL1 EPHA6 PIK3CA PEAK1 TEK EPHA5	4.00e-04	709	51	8	GO:0016773
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	JAK2 MAP2K4 ABL1 EPHA6 PIK3CA PEAK1 TEK MTPAP EPHA5	5.50e-04	938	51	9	GO:0016772
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	EPHA6 TEK EPHA5	6.13e-04	65	51	3	GO:0004714
GeneOntologyMolecularFunction	kinase activity	JAK2 MAP2K4 ABL1 EPHA6 PIK3CA PEAK1 TEK EPHA5	6.56e-04	764	51	8	GO:0016301
GeneOntologyMolecularFunction	transmembrane-ephrin receptor activity	EPHA6 EPHA5	6.57e-04	15	51	2	GO:0005005
GeneOntologyMolecularFunction	ephrin receptor activity	EPHA6 EPHA5	1.06e-03	19	51	2	GO:0005003
GeneOntologyMolecularFunction	peptide hormone receptor binding	JAK2 PTPN11	1.30e-03	21	51	2	GO:0051428
GeneOntologyMolecularFunction	transmembrane receptor protein kinase activity	EPHA6 TEK EPHA5	1.34e-03	85	51	3	GO:0019199
GeneOntologyMolecularFunction	G protein-coupled receptor binding	JAK2 PTPN11 DNAJC14 WNT9B GPRC5B	1.65e-03	337	51	5	GO:0001664
GeneOntologyMolecularFunction	metallopeptidase activity	PAPPA2 ANPEP AGBL2 ADAM12	1.69e-03	200	51	4	GO:0008237
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	VN1R4 OR5M10 OR5M1 EPHA6 TAS1R2 TEK IL22RA1 PTPRT GPRC5B EPHA5	1.96e-03	1353	51	10	GO:0004888
GeneOntologyMolecularFunction	dopamine receptor binding	PTPN11 DNAJC14	2.00e-03	26	51	2	GO:0050780
GeneOntologyMolecularFunction	actin monomer binding	ABL1 COBL	2.48e-03	29	51	2	GO:0003785
GeneOntologyMolecularFunction	adenylyltransferase activity	ABL1 MTPAP	2.84e-03	31	51	2	GO:0070566
GeneOntologyMolecularFunction	hormone receptor binding	JAK2 PTPN11	3.41e-03	34	51	2	GO:0051427
GeneOntologyMolecularFunction	odorant binding	VN1R4 OR5M10 OR5M1	4.19e-03	127	51	3	GO:0005549
GeneOntologyBiologicalProcess	positive regulation of transferase activity	JAK2 MAP2K4 ABL1 UBE2I PIK3CA TEK GPRC5B EPHA5	2.14e-05	490	50	8	GO:0051347
GeneOntologyBiologicalProcess	regulation of focal adhesion assembly	PTPN11 ABL1 PEAK1 TEK	2.49e-05	70	50	4	GO:0051893
GeneOntologyBiologicalProcess	regulation of cell-substrate junction assembly	PTPN11 ABL1 PEAK1 TEK	2.49e-05	70	50	4	GO:0090109
GeneOntologyBiologicalProcess	regulation of cell-substrate junction organization	PTPN11 ABL1 PEAK1 TEK	3.27e-05	75	50	4	GO:0150116
GeneOntologyBiologicalProcess	positive regulation of kinase activity	JAK2 MAP2K4 ABL1 PIK3CA TEK GPRC5B EPHA5	5.15e-05	405	50	7	GO:0033674
GeneOntologyBiologicalProcess	positive regulation of focal adhesion assembly	PTPN11 ABL1 TEK	5.74e-05	31	50	3	GO:0051894
GeneOntologyBiologicalProcess	cell surface receptor protein tyrosine kinase signaling pathway	JAK2 PTPN11 ABL1 EPHA6 PIK3CA ARTN TEK PTPRT EPHA5	6.75e-05	747	50	9	GO:0007169
GeneOntologyBiologicalProcess	focal adhesion assembly	PTPN11 ABL1 PEAK1 TEK	8.97e-05	97	50	4	GO:0048041
GeneOntologyBiologicalProcess	positive regulation of cell-substrate junction organization	PTPN11 ABL1 TEK	9.05e-05	36	50	3	GO:0150117
GeneOntologyBiologicalProcess	regulation of transferase activity	JAK2 MAP2K4 ABL1 UBE2I PIK3CA TEK PTPRT GPRC5B EPHA5	1.25e-04	810	50	9	GO:0051338
GeneOntologyBiologicalProcess	cell-substrate junction assembly	PTPN11 ABL1 PEAK1 TEK	1.36e-04	108	50	4	GO:0007044
GeneOntologyBiologicalProcess	anatomical structure formation involved in morphogenesis	FLNC PTPN11 ABL1 ANPEP PIK3CA WNT9B COBL NEB TEK ADAM12 GNPAT EPHA5	1.70e-04	1483	50	12	GO:0048646
GeneOntologyBiologicalProcess	cell-substrate junction organization	PTPN11 ABL1 PEAK1 TEK	1.73e-04	115	50	4	GO:0150115
GeneOntologyBiologicalProcess	regulation of kinase activity	JAK2 MAP2K4 ABL1 PIK3CA TEK PTPRT GPRC5B EPHA5	2.24e-04	686	50	8	GO:0043549
GeneOntologyBiologicalProcess	ephrin receptor signaling pathway	PTPN11 EPHA6 EPHA5	3.05e-04	54	50	3	GO:0048013
GeneOntologyBiologicalProcess	regulation of cell-substrate adhesion	JAK2 PTPN11 ABL1 PEAK1 TEK	3.67e-04	254	50	5	GO:0010810
GeneOntologyBiologicalProcess	Bergmann glial cell differentiation	PTPN11 ABL1	3.74e-04	12	50	2	GO:0060020
GeneOntologyBiologicalProcess	regulation of cell-matrix adhesion	PTPN11 ABL1 PEAK1 TEK	3.78e-04	141	50	4	GO:0001952
GeneOntologyBiologicalProcess	cerebellum morphogenesis	PTPN11 ABL1 GNPAT	4.16e-04	60	50	3	GO:0021587
GeneOntologyBiologicalProcess	positive regulation of platelet aggregation	JAK2 MFSD2B	4.42e-04	13	50	2	GO:1901731
GeneOntologyBiologicalProcess	positive regulation of cell-substrate adhesion	JAK2 PTPN11 ABL1 TEK	4.65e-04	149	50	4	GO:0010811
GeneOntologyBiologicalProcess	hindbrain morphogenesis	PTPN11 ABL1 GNPAT	5.03e-04	64	50	3	GO:0021575
GeneOntologyBiologicalProcess	positive regulation of phosphorylation	JAK2 MAP2K4 PTPN11 ABL1 PIK3CA TEK GPRC5B EPHA5	5.30e-04	780	50	8	GO:0042327
GeneOntologyBiologicalProcess	regulation of phosphorylation	JAK2 MAP2K4 PTPN11 ABL1 PIK3CA WNT9B TEK PTPRT GPRC5B EPHA5	6.15e-04	1226	50	10	GO:0042325
GeneOntologyBiologicalProcess	positive regulation of cell-matrix adhesion	PTPN11 ABL1 TEK	6.27e-04	69	50	3	GO:0001954
GeneOntologyBiologicalProcess	response to fatty acid	PIK3CA OAZ1 GNPAT	6.27e-04	69	50	3	GO:0070542
GeneOntologyBiologicalProcess	platelet-derived growth factor receptor signaling pathway	JAK2 PTPN11 ABL1	6.82e-04	71	50	3	GO:0048008
GeneOntologyBiologicalProcess	positive regulation of catalytic activity	JAK2 MAP2K4 ABL1 UBE2I PIK3CA WNT9B TEK GPRC5B EPHA5	7.25e-04	1028	50	9	GO:0043085
GeneOntologyCellularComponent	actin cytoskeleton	FLNC PTPN11 ABL1 ARSJ COBL PEAK1 NEB TEK	8.18e-05	576	52	8	GO:0015629
Domain	PROTEIN_KINASE_TYR	JAK2 ABL1 EPHA6 PEAK1 TEK EPHA5	2.50e-07	97	51	6	PS00109
Domain	Tyr_kinase_AS	JAK2 ABL1 EPHA6 PEAK1 TEK EPHA5	2.50e-07	97	51	6	IPR008266
Domain	FN3_dom	PAPPA2 FLNC EPHA6 TEK IL22RA1 PTPRT EPHA5	1.52e-06	209	51	7	IPR003961
Domain	TyrKc	JAK2 ABL1 EPHA6 TEK EPHA5	4.10e-06	88	51	5	SM00219
Domain	Tyr_kinase_cat_dom	JAK2 ABL1 EPHA6 TEK EPHA5	4.10e-06	88	51	5	IPR020635
Domain	FN3	PAPPA2 FLNC EPHA6 TEK PTPRT EPHA5	1.08e-05	185	51	6	SM00060
Domain	Kinase-like_dom	JAK2 MAP2K4 ABL1 EPHA6 PIK3CA PEAK1 TEK PRDM2 EPHA5	1.40e-05	542	51	9	IPR011009
Domain	Pkinase_Tyr	JAK2 ABL1 EPHA6 TEK EPHA5	2.65e-05	129	51	5	PF07714
Domain	Ser-Thr/Tyr_kinase_cat_dom	JAK2 ABL1 EPHA6 TEK EPHA5	3.66e-05	138	51	5	IPR001245
Domain	FN3	EPHA6 TEK IL22RA1 PTPRT EPHA5	2.06e-04	199	51	5	PS50853
Domain	PROTEIN_KINASE_ATP	JAK2 MAP2K4 ABL1 EPHA6 PEAK1 TEK EPHA5	2.35e-04	459	51	7	PS00107
Domain	Prot_kinase_dom	JAK2 MAP2K4 ABL1 EPHA6 PEAK1 TEK EPHA5	3.45e-04	489	51	7	IPR000719
Domain	PROTEIN_KINASE_DOM	JAK2 MAP2K4 ABL1 EPHA6 PEAK1 TEK EPHA5	3.63e-04	493	51	7	PS50011
Domain	Protein_kinase_ATP_BS	JAK2 MAP2K4 ABL1 EPHA6 TEK EPHA5	5.59e-04	379	51	6	IPR017441
Domain	RECEPTOR_TYR_KIN_V_2	EPHA6 EPHA5	6.51e-04	14	51	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHA6 EPHA5	6.51e-04	14	51	2	PS00790
Domain	Eph_TM	EPHA6 EPHA5	6.51e-04	14	51	2	IPR027936
Domain	Tyr_kinase_rcpt_V_CS	EPHA6 EPHA5	6.51e-04	14	51	2	IPR001426
Domain	EPH_lbd	EPHA6 EPHA5	6.51e-04	14	51	2	SM00615
Domain	Ephrin_lbd	EPHA6 EPHA5	6.51e-04	14	51	2	PF01404
Domain	EphA2_TM	EPHA6 EPHA5	6.51e-04	14	51	2	PF14575
Domain	Tyr_kinase_ephrin_rcpt	EPHA6 EPHA5	6.51e-04	14	51	2	IPR016257
Domain	Ephrin_rcpt_lig-bd_dom	EPHA6 EPHA5	6.51e-04	14	51	2	IPR001090
Domain	EPH_LBD	EPHA6 EPHA5	6.51e-04	14	51	2	PS51550
Domain	fn3	EPHA6 TEK PTPRT EPHA5	9.92e-04	162	51	4	PF00041
Domain	-	EPHA6 HECTD3 EPHA5	1.04e-03	73	51	3	2.60.120.260
Domain	GPCR_3	TAS1R2 GPRC5B	1.49e-03	21	51	2	IPR000337
Domain	7tm_3	TAS1R2 GPRC5B	1.63e-03	22	51	2	PF00003
Domain	G_PROTEIN_RECEP_F3_2	TAS1R2 GPRC5B	1.63e-03	22	51	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	TAS1R2 GPRC5B	1.63e-03	22	51	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	TAS1R2 GPRC5B	1.63e-03	22	51	2	PS00979
Domain	G_PROTEIN_RECEP_F3_4	TAS1R2 GPRC5B	1.63e-03	22	51	2	PS50259
Domain	GPCR_3_C	TAS1R2 GPRC5B	1.63e-03	22	51	2	IPR017978
Domain	-	PAPPA2 FLNC EPHA6 TEK IL22RA1 PTPRT EPHA5	2.05e-03	663	51	7	2.60.40.10
Domain	Ephrin_rec_like	EPHA6 EPHA5	2.11e-03	25	51	2	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHA6 EPHA5	2.11e-03	25	51	2	IPR011641
Domain	Galactose-bd-like	EPHA6 HECTD3 EPHA5	2.16e-03	94	51	3	IPR008979
Domain	ZINC_PROTEASE	PAPPA2 ANPEP ADAM12	2.43e-03	98	51	3	PS00142
Domain	SH2	JAK2 PTPN11 ABL1	2.65e-03	101	51	3	PF00017
Domain	Ig-like_fold	PAPPA2 FLNC EPHA6 TEK IL22RA1 PTPRT EPHA5	2.91e-03	706	51	7	IPR013783
Domain	SH2	JAK2 PTPN11 ABL1	3.37e-03	110	51	3	SM00252
Domain	SH2	JAK2 PTPN11 ABL1	3.46e-03	111	51	3	PS50001
Domain	SH2	JAK2 PTPN11 ABL1	3.55e-03	112	51	3	IPR000980
Domain	-	JAK2 PTPN11 ABL1	3.55e-03	112	51	3	3.30.505.10
Domain	PTPc	PTPN11 PTPRT	4.34e-03	36	51	2	SM00194
Domain	TYR_PHOSPHATASE_PTP	PTPN11 PTPRT	5.08e-03	39	51	2	PS50055
Domain	PTPase_domain	PTPN11 PTPRT	5.60e-03	41	51	2	IPR000242
Domain	Y_phosphatase	PTPN11 PTPRT	5.60e-03	41	51	2	PF00102
Domain	DnaJ	HSCB DNAJC14	7.61e-03	48	51	2	PF00226
Pathway	PID_IL5_PATHWAY	JAK2 PTPN11 PIK3CA	1.01e-05	14	44	3	M135
Pathway	PID_IL6_7_PATHWAY	JAK2 MAP2K4 PTPN11 PIK3CA	1.34e-05	47	44	4	M183
Pathway	REACTOME_TIE2_SIGNALING	PTPN11 PIK3CA TEK	1.87e-05	17	44	3	MM14836
Pathway	REACTOME_TIE2_SIGNALING	PTPN11 PIK3CA TEK	2.24e-05	18	44	3	M11932
Pathway	PID_SHP2_PATHWAY	JAK2 PTPN11 PIK3CA TEK	2.89e-05	57	44	4	M100
Pathway	REACTOME_INTERLEUKIN_20_FAMILY_SIGNALING	JAK2 PTPN11 IL22RA1	3.12e-05	20	44	3	MM15496
Pathway	BIOCARTA_GLEEVEC_PATHWAY	JAK2 MAP2K4 PIK3CA	4.81e-05	23	44	3	MM1424
Pathway	BIOCARTA_GLEEVEC_PATHWAY	JAK2 MAP2K4 PIK3CA	4.81e-05	23	44	3	M7897
Pathway	PID_PDGFRB_PATHWAY	JAK2 MAP2K4 PTPN11 ABL1 PIK3CA	4.84e-05	129	44	5	M186
Pathway	REACTOME_INTERLEUKIN_20_FAMILY_SIGNALING	JAK2 PTPN11 IL22RA1	7.02e-05	26	44	3	M27750
Pathway	PID_IL3_PATHWAY	JAK2 PTPN11 PIK3CA	7.02e-05	26	44	3	M182
Pathway	WP_PDGFRBETA_PATHWAY	JAK2 MAP2K4 PIK3CA	9.80e-05	29	44	3	M39616
Pathway	WP_TYPE_II_INTERFERON_SIGNALING_IFNG	JAK2 PTPN11 PSMB9	1.20e-04	31	44	3	MM15958
Pathway	PID_GMCSF_PATHWAY	JAK2 PTPN11 PIK3CA	1.89e-04	36	44	3	M22
Pathway	WP_TYPE_II_INTERFERON_SIGNALING	JAK2 PTPN11 PSMB9	2.05e-04	37	44	3	M39363
Pathway	REACTOME_SIGNALING_BY_SCF_KIT	JAK2 PTPN11 PIK3CA	2.05e-04	37	44	3	MM14564
Pathway	REACTOME_RET_SIGNALING	PTPN11 PIK3CA ARTN	2.22e-04	38	44	3	MM15493
Pathway	REACTOME_RET_SIGNALING	PTPN11 PIK3CA ARTN	2.59e-04	40	44	3	M27746
Pathway	PID_IFNG_PATHWAY	JAK2 PTPN11 PIK3CA	2.59e-04	40	44	3	M161
Pathway	REACTOME_MAPK1_ERK2_ACTIVATION	JAK2 PTPN11	2.63e-04	8	44	2	MM14507
Pathway	REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING	JAK2 PTPN11 PIK3CA	2.78e-04	41	44	3	MM15162
Pathway	WP_IL6_SIGNALING	JAK2 MAP2K4 PTPN11	3.21e-04	43	44	3	M39656
Pathway	REACTOME_SIGNALING_BY_SCF_KIT	JAK2 PTPN11 PIK3CA	3.21e-04	43	44	3	M508
Pathway	REACTOME_MAPK3_ERK1_ACTIVATION	JAK2 PTPN11	3.38e-04	9	44	2	MM14474
Pathway	REACTOME_INTERLEUKIN_6_SIGNALING	JAK2 PTPN11	3.38e-04	9	44	2	MM14470
Pathway	REACTOME_MAPK1_ERK2_ACTIVATION	JAK2 PTPN11	3.38e-04	9	44	2	M26918
Pathway	PID_ERBB2_ERBB3_PATHWAY	JAK2 PTPN11 PIK3CA	3.44e-04	44	44	3	M175
Pathway	WP_THYMIC_STROMAL_LYMPHOPOIETIN_TSLP_SIGNALING	JAK2 PTPN11 PIK3CA	4.18e-04	47	44	3	M39380
Pathway	REACTOME_MAPK3_ERK1_ACTIVATION	JAK2 PTPN11	4.22e-04	10	44	2	M26896
Pathway	REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING	JAK2 PTPN11 PIK3CA	4.45e-04	48	44	3	M914
Pathway	PID_ANGIOPOIETIN_RECEPTOR_PATHWAY	PTPN11 PIK3CA TEK	4.73e-04	49	44	3	M92
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	JAK2 PTPN11 PIK3CA PSMB9 ARTN TEK	5.00e-04	327	44	6	M27565
Pathway	KEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY	ABL1 PIK3CA	5.14e-04	11	44	2	M47406
Pathway	REACTOME_SIGNALING_BY_LEPTIN	JAK2 PTPN11	5.14e-04	11	44	2	M27195
Pathway	REACTOME_INTERLEUKIN_6_SIGNALING	JAK2 PTPN11	5.14e-04	11	44	2	M1014
Pathway	PID_KIT_PATHWAY	JAK2 PTPN11 PIK3CA	5.64e-04	52	44	3	M231
Pathway	REACTOME_SIGNALING_BY_EGFR	PTPN11 PIK3CA ADAM12	5.96e-04	53	44	3	M27039
Pathway	REACTOME_ERYTHROPOIETIN_ACTIVATES_PHOSPHOINOSITIDE_3_KINASE_PI3K	JAK2 PIK3CA	6.16e-04	12	44	2	M27905
Pathway	REACTOME_ERYTHROPOIETIN_ACTIVATES_PHOSPHOINOSITIDE_3_KINASE_PI3K	JAK2 PIK3CA	6.16e-04	12	44	2	MM15623
Pathway	WP_IL4_SIGNALING	JAK2 PTPN11 PIK3CA	6.30e-04	54	44	3	M39720
Pathway	WP_CANCER_IMMUNOTHERAPY_BY_CTLA4_BLOCKADE	PTPN11 PIK3CA	8.46e-04	14	44	2	M39840
Pathway	REACTOME_REGULATION_OF_IFNG_SIGNALING	JAK2 PTPN11	8.46e-04	14	44	2	M942
Pathway	PID_FCER1_PATHWAY	MAP2K4 PTPN11 PIK3CA	8.57e-04	60	44	3	M7
Pathway	PID_TRKR_PATHWAY	PTPN11 ABL1 PIK3CA	9.00e-04	61	44	3	M187
Pathway	KEGG_MEDICUS_ENV_FACTOR_METALS_TO_NFKB_SIGNALING_PATHWAY	PTPN11 ABL1	9.74e-04	15	44	2	M47816
Pathway	REACTOME_PROLACTIN_RECEPTOR_SIGNALING	JAK2 PTPN11	9.74e-04	15	44	2	M552
Pathway	BIOCARTA_ARF_PATHWAY	ABL1 PIK3CA	1.11e-03	16	44	2	MM1524
Pathway	BIOCARTA_CTLA4_PATHWAY	PTPN11 PIK3CA	1.11e-03	16	44	2	MM1512
Pathway	REACTOME_SIGNALING_BY_FLT3_ITD_AND_TKD_MUTANTS	PTPN11 PIK3CA	1.11e-03	16	44	2	M41733
Pathway	WP_RAC1PAK1P38MMP2_PATHWAY	PTPN11 PIK3CA TEK	1.23e-03	68	44	3	M39456
Pathway	REACTOME_SIGNALING_BY_ERYTHROPOIETIN	JAK2 PIK3CA	1.26e-03	17	44	2	MM15584
Pathway	REACTOME_GAB1_SIGNALOSOME	PTPN11 PIK3CA	1.26e-03	17	44	2	MM14700
Pathway	REACTOME_GAB1_SIGNALOSOME	PTPN11 PIK3CA	1.26e-03	17	44	2	M10450
Pathway	BIOCARTA_ARF_PATHWAY	ABL1 PIK3CA	1.26e-03	17	44	2	M11358
Pathway	REACTOME_NERVOUS_SYSTEM_DEVELOPMENT	PTPN11 ABL1 EPHA6 PIK3CA ARTN	1.26e-03	261	44	5	MM15676
Pathway	KEGG_JAK_STAT_SIGNALING_PATHWAY	JAK2 PTPN11 PIK3CA IL22RA1	1.36e-03	155	44	4	M17411
Pathway	WP_KIT_RECEPTOR_SIGNALING_PATHWAY	JAK2 PTPN11 ABL1	1.40e-03	71	44	3	MM15947
Pathway	REACTOME_PI_3K_CASCADE_FGFR3	PTPN11 PIK3CA	1.41e-03	18	44	2	M27521
Pathway	REACTOME_PI_3K_CASCADE_FGFR3	PTPN11 PIK3CA	1.41e-03	18	44	2	MM15247
Pathway	KEGG_CHRONIC_MYELOID_LEUKEMIA	PTPN11 ABL1 PIK3CA	1.52e-03	73	44	3	M321
Pathway	WP_PROLACTIN_SIGNALING	JAK2 PTPN11 PIK3CA	1.70e-03	76	44	3	M39601
Pathway	REACTOME_PI_3K_CASCADE_FGFR4	PTPN11 PIK3CA	1.75e-03	20	44	2	M27525
Pathway	REACTOME_PI_3K_CASCADE_FGFR4	PTPN11 PIK3CA	1.75e-03	20	44	2	MM15251
Pathway	REACTOME_SIGNALING_BY_KIT_IN_DISEASE	JAK2 PIK3CA	1.75e-03	20	44	2	M39002
Pathway	REACTOME_SIGNALING_BY_INTERLEUKINS	JAK2 MAP2K4 PTPN11 PIK3CA IL22RA1	1.75e-03	281	44	5	MM15130
Pathway	WP_REGULATORY_CIRCUITS_OF_STAT3_SIGNALING	JAK2 IL22RA1 PTPRT	1.83e-03	78	44	3	M39824
Pathway	REACTOME_NERVOUS_SYSTEM_DEVELOPMENT	PTPN11 ABL1 EPHA6 PIK3CA PSMB9 ARTN EPHA5	1.87e-03	575	44	7	M29853
Pathway	PID_MET_PATHWAY	MAP2K4 PTPN11 PIK3CA	1.90e-03	79	44	3	M48
Pathway	REACTOME_PI_3K_CASCADE_FGFR1	PTPN11 PIK3CA	1.93e-03	21	44	2	M27512
Pathway	BIOCARTA_IGF1_PATHWAY	PTPN11 PIK3CA	1.93e-03	21	44	2	M2623
Pathway	WP_GNAQ_PATHWAYS_IN_PORTWINE_STAIN	MAP2K4 PIK3CA	1.93e-03	21	44	2	M48342
Pathway	BIOCARTA_IL6_PATHWAY	JAK2 PTPN11	1.93e-03	21	44	2	M5489
Pathway	REACTOME_PI_3K_CASCADE_FGFR1	PTPN11 PIK3CA	1.93e-03	21	44	2	MM15238
Pathway	BIOCARTA_INSULIN_PATHWAY	PTPN11 PIK3CA	1.93e-03	21	44	2	M765
Pathway	WP_VEGFAVEGFR2_SIGNALING	MAP2K4 PTPN11 ABL1 PIK3CA NAP1L1 ASCC3	2.08e-03	431	44	6	M39729
Pathway	REACTOME_INTERLEUKIN_6_FAMILY_SIGNALING	JAK2 PTPN11	2.11e-03	22	44	2	MM15319
Pathway	BIOCARTA_IGF1_PATHWAY	PTPN11 PIK3CA	2.11e-03	22	44	2	MM1409
Pathway	BIOCARTA_IL6_PATHWAY	JAK2 PTPN11	2.11e-03	22	44	2	MM1415
Pathway	REACTOME_SIGNALING_BY_CSF3_G_CSF	JAK2 PTPN11	2.11e-03	22	44	2	MM15675
Pathway	REACTOME_PI_3K_CASCADE_FGFR2	PTPN11 PIK3CA	2.11e-03	22	44	2	MM15240
Pathway	REACTOME_RAF_INDEPENDENT_MAPK1_3_ACTIVATION	JAK2 PTPN11	2.11e-03	22	44	2	MM14506
Pathway	BIOCARTA_CTLA4_PATHWAY	PTPN11 PIK3CA	2.11e-03	22	44	2	M1467
Pathway	REACTOME_INTERLEUKIN_RECEPTOR_SHC_SIGNALING	JAK2 PIK3CA	2.11e-03	22	44	2	MM15632
Pathway	REACTOME_PI_3K_CASCADE_FGFR2	PTPN11 PIK3CA	2.31e-03	23	44	2	M27514
Pathway	REACTOME_RAF_INDEPENDENT_MAPK1_3_ACTIVATION	JAK2 PTPN11	2.31e-03	23	44	2	M26917
Pathway	WP_IL2_SIGNALING_PATHWAY	JAK2 PTPN11 PIK3CA	2.50e-03	87	44	3	MM15915
Pathway	KEGG_ERBB_SIGNALING_PATHWAY	MAP2K4 ABL1 PIK3CA	2.50e-03	87	44	3	M12467
Pathway	WP_KALLMANN_SYNDROME	PTPN11 PIK3CA	2.52e-03	24	44	2	M42530
Pathway	WP_ANGIOGENESIS	PIK3CA TEK	2.52e-03	24	44	2	M39556
Pathway	REACTOME_INTERLEUKIN_6_FAMILY_SIGNALING	JAK2 PTPN11	2.52e-03	24	44	2	M27604
Pathway	BIOCARTA_INSULIN_PATHWAY	PTPN11 PIK3CA	2.52e-03	24	44	2	MM1425
Pathway	REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR3	PTPN11 PIK3CA	2.52e-03	24	44	2	MM15246
Pathway	BIOCARTA_TPO_PATHWAY	JAK2 PIK3CA	2.52e-03	24	44	2	M11520
Pathway	WP_RAS_SIGNALING	PTPN11 ABL1 PIK3CA TEK	2.54e-03	184	44	4	M39764
Pathway	REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR3	PTPN11 PIK3CA	2.73e-03	25	44	2	M27520
Pathway	BIOCARTA_TPO_PATHWAY	JAK2 PIK3CA	2.73e-03	25	44	2	MM1519
Pathway	PID_LYMPH_ANGIOGENESIS_PATHWAY	MAP2K4 PIK3CA	2.73e-03	25	44	2	M274
Pathway	REACTOME_SIGNALING_BY_NTRK2_TRKB	PTPN11 PIK3CA	2.73e-03	25	44	2	M27864
Pathway	REACTOME_SIGNALING_BY_ERYTHROPOIETIN	JAK2 PIK3CA	2.73e-03	25	44	2	M27865
Pathway	WP_ERBB_SIGNALING	MAP2K4 ABL1 PIK3CA	2.94e-03	92	44	3	M39715
Pubmed	Genetic mutations associated with cigarette smoking in pancreatic cancer.	JAK2 MAP2K4 PTPN11 PIK3CA PTPRT	4.04e-08	63	52	5	19351817
Pubmed	The protein tyrosine kinase family of the human genome.	JAK2 ABL1 EPHA6 TEK EPHA5	1.63e-07	83	52	5	11114734
Pubmed	Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences.	JAK2 ABL1 PIK3CA	5.16e-07	11	52	3	16135792
Pubmed	Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.	MAP2K4 EPHA6 EPHA5	1.74e-06	16	52	3	8755474
Pubmed	Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop.	JAK2 ABL1	2.19e-06	2	52	2	9111318
Pubmed	Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity.	JAK2 ABL1	2.19e-06	2	52	2	15143187
Pubmed	Combination of the ABL kinase inhibitor imatinib with the Janus kinase 2 inhibitor TG101348 for targeting residual BCR-ABL-positive cells.	JAK2 ABL1	2.19e-06	2	52	2	24775308
Pubmed	Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation.	JAK2 ABL1	2.19e-06	2	52	2	11593427
Pubmed	Two cases of myeloproliferative neoplasm with a concurrent JAK2 (V617F) mutation and BCR/ABL translocation without chronic myelogenous leukemia phenotype acquisition during hydroxyurea treatment.	JAK2 ABL1	2.19e-06	2	52	2	23667855
Pubmed	Myeloproliferative neoplasms with concurrent BCR-ABL1 translocation and JAK2 V617F mutation: a multi-institutional study from the bone marrow pathology group.	JAK2 ABL1	2.19e-06	2	52	2	29327708
Pubmed	Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans.	JAK2 PTPRT	2.19e-06	2	52	2	31844068
Pubmed	c-Abl activates janus kinase 2 in normal hematopoietic cells.	JAK2 ABL1	2.19e-06	2	52	2	24923444
Pubmed	Hypoxia inhibits JAK2V617F activation via suppression of SHP-2 function in myeloproliferative neoplasm cells.	JAK2 PTPN11	2.19e-06	2	52	2	24860972
Pubmed	Deficiency in the p110alpha subunit of PI3K results in diminished Tie2 expression and Tie2(-/-)-like vascular defects in mice.	PIK3CA TEK	2.19e-06	2	52	2	15687236
Pubmed	[Analysis of Clinical Characteristics of JAK2 V617F and BCR-ABL Double-Mutant Myeloproliferative Neoplasms].	JAK2 ABL1	2.19e-06	2	52	2	34627437
Pubmed	Erythropoietin protects retinal pigment epithelial cells against the increase of permeability induced by diabetic conditions: essential role of JAK2/ PI3K signaling.	JAK2 PIK3CA	2.19e-06	2	52	2	21620963
Pubmed	Mutational analysis of PIK3CA, JAK2, BRAF, FOXL2, IDH1, AKT1 and EZH2 oncogenes in sarcomas.	JAK2 PIK3CA	2.19e-06	2	52	2	22779686
Pubmed	Chronic myeloproliferative diseases with concurrent BCR-ABL junction and JAK2V617F mutation.	JAK2 ABL1	2.19e-06	2	52	2	17972958
Pubmed	Syp associates with gp130 and Janus kinase 2 in response to interleukin-11 in 3T3-L1 mouse preadipocytes.	JAK2 PTPN11	2.19e-06	2	52	2	7559603
Pubmed	Identification of novel protein kinases expressed in the myocardium of the developing mouse heart.	JAK2 ABL1 TEK	3.53e-06	20	52	3	7893599
Pubmed	Chromosomal localization of the proteasome Z subunit gene reveals an ancient chromosomal duplication involving the major histocompatibility complex.	ABL1 FPGS PSMB9	5.47e-06	23	52	3	8799160
Pubmed	Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis.	JAK2 PTPN11	6.57e-06	3	52	2	8639815
Pubmed	BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia.	JAK2 ABL1	6.57e-06	3	52	2	22286129
Pubmed	Concomitant BCR-ABL1 translocation and JAK2(V617F) mutation in three patients with myeloproliferative neoplasms.	JAK2 ABL1	6.57e-06	3	52	2	22847163
Pubmed	Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains.	PTPN11 ABL1	6.57e-06	3	52	2	23980151
Pubmed	Concomitant detection of BCR-ABL translocation and JAK2 V617F mutation in five patients with myeloproliferative neoplasm at diagnosis.	JAK2 ABL1	6.57e-06	3	52	2	23062104
Pubmed	Acquisition of JAK2, PTPN11, and RAS mutations during disease progression in primary myelodysplastic syndrome.	JAK2 PTPN11	6.57e-06	3	52	2	16598312
Pubmed	SHPTP2 serves adapter protein linking between Janus kinase 2 and insulin receptor substrates.	JAK2 PTPN11	6.57e-06	3	52	2	8912646
Pubmed	Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic β-Catenin, PIK3CA and MET.	PTPN11 PIK3CA	6.57e-06	3	52	2	29505847
Pubmed	Targeted Sequencing Reveals Low-Frequency Variants in EPHA Genes as Markers of Paclitaxel-Induced Peripheral Neuropathy.	EPHA6 EPHA5	6.57e-06	3	52	2	27582484
Pubmed	BioID-Screening Identifies PEAK1 and SHP2 as Components of the ALK Proximitome in Neuroblastoma Cells.	PTPN11 PEAK1	6.57e-06	3	52	2	34273398
Pubmed	Janus kinase 2 regulates Bcr-Abl signaling in chronic myeloid leukemia.	JAK2 ABL1	6.57e-06	3	52	2	21183952
Pubmed	PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML.	PTPN11 PIK3CA	6.57e-06	3	52	2	24553178
Pubmed	The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl.	JAK2 PIK3CA	6.57e-06	3	52	2	7534285
Pubmed	Substrate specificities and identification of putative substrates of ATM kinase family members.	LIG4 ABL1 PIK3CA	7.08e-06	25	52	3	10608806
Pubmed	CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia.	JAK2 PTPN11 ABL1 TEK	9.02e-06	87	52	4	29991678
Pubmed	Mutational status of EGFR, BRAF, PI3KCA and JAK2 genes in endocrine tumors.	JAK2 PIK3CA	1.31e-05	4	52	2	19003996
Pubmed	Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases.	JAK2 PTPN11	1.31e-05	4	52	2	8995399
Pubmed	Expression and prognostic roles of PIK3CA, JAK2, PD-L1, and PD-L2 in Epstein-Barr virus-associated gastric carcinoma.	JAK2 PIK3CA	1.31e-05	4	52	2	26980034
Pubmed	JAK2 and SHP2 reciprocally regulate tyrosine phosphorylation and stability of proapoptotic protein ASK1.	JAK2 PTPN11	1.31e-05	4	52	2	19287004
Pubmed	Screening for hotspot mutations in PI3K, JAK2, FLT3 and NPM1 in patients with myelodysplastic syndromes.	JAK2 PIK3CA	1.31e-05	4	52	2	21789382
Pubmed	Involvement of the Src homology 2-containing tyrosine phosphatase SHP-2 in growth hormone signaling.	JAK2 PTPN11	1.31e-05	4	52	2	9442080
Pubmed	Roles of phosphatidylinositol 3-kinase in interferon-gamma-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression.	JAK2 PIK3CA	1.31e-05	4	52	2	11438544
Pubmed	SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor.	JAK2 PTPN11	1.31e-05	4	52	2	14522994
Pubmed	Somatic mutation spectrum of a Chinese cohort of pediatrics with vascular malformations.	PIK3CA TEK	1.31e-05	4	52	2	37658401
Pubmed	SHP-2 is a novel target of Abl kinases during cell proliferation.	PTPN11 ABL1	1.31e-05	4	52	2	18827006
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	LIG4 PTPN11 ABL1 PIK3CA FPGS ASCC3	1.39e-05	351	52	6	20453000
Pubmed	Murine txk: a protein tyrosine kinase gene regulated by T cell activation.	JAK2 ABL1 TEK	1.52e-05	32	52	3	7542761
Pubmed	Dehydrocostus Lactone Suppresses Proliferation of Human Chronic Myeloid Leukemia Cells Through Bcr/Abl-JAK/STAT Signaling Pathways.	JAK2 ABL1	2.19e-05	5	52	2	28300289
Pubmed	Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling.	PTPN11 PIK3CA	2.19e-05	5	52	2	20308328
Pubmed	Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2(V617F) in mice.	JAK2 ABL1	2.19e-05	5	52	2	22234689
Pubmed	His-1 and His-2: identification and chromosomal mapping of two commonly rearranged sites of viral integration in a myeloid leukemia.	ABL1 NEB	2.19e-05	5	52	2	1682866
Pubmed	The phosphatidylinositol polyphosphate 5-phosphatase SHIP and the protein tyrosine phosphatase SHP-2 form a complex in hematopoietic cells which can be regulated by BCR/ABL and growth factors.	PTPN11 ABL1	2.19e-05	5	52	2	9393882
Pubmed	Association of Shp2 with phosphorylated IL-22R1 is required for interleukin-22-induced MAP kinase activation.	PTPN11 IL22RA1	2.19e-05	5	52	2	20671117
Pubmed	Mutation Profile in BCR-ABL1-Negative Myeloproliferative Neoplasms: A Single-Center Experience From India.	JAK2 ABL1	2.19e-05	5	52	2	33789164
Pubmed	Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.	PTPN11 ABL1	2.19e-05	5	52	2	11266449
Pubmed	Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells.	JAK2 PTPN11	2.19e-05	5	52	2	9388212
Pubmed	eIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants.	ABL1 PIK3CA	3.28e-05	6	52	2	26848623
Pubmed	Induction of metastatic potential by TrkB via activation of IL6/JAK2/STAT3 and PI3K/AKT signaling in breast cancer.	JAK2 PIK3CA	3.28e-05	6	52	2	26515594
Pubmed	The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells.	PTPN11 PIK3CA	3.28e-05	6	52	2	9565634
Pubmed	Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells.	FLNC MAP2K4	3.28e-05	6	52	2	9006895
Pubmed	Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.	PTPN11 TEK	3.28e-05	6	52	2	10521483
Pubmed	Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction.	JAK2 PTPN11	3.28e-05	6	52	2	15677447
Pubmed	Essential role of HDAC6 in the regulation of PD-L1 in melanoma.	JAK2 PTPN11	3.28e-05	6	52	2	26775640
Pubmed	Opposing gradients of ephrin-As and EphA7 in the superior colliculus are essential for topographic mapping in the mammalian visual system.	EPHA6 EPHA5	3.28e-05	6	52	2	15996548
Pubmed	Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.	EPHA6 TEK EPHA5	3.47e-05	42	52	3	11439183
Pubmed	SUMO-1 represses apoptosis signal-regulating kinase 1 activation through physical interaction and not through covalent modification.	MAP2K4 UBE2I	4.58e-05	7	52	2	16142216
Pubmed	Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes.	PTPN11 ABL1	4.58e-05	7	52	2	8879209
Pubmed	Novel Roles and Mechanism for Krüppel-like Factor 16 (KLF16) Regulation of Neurite Outgrowth and Ephrin Receptor A5 (EphA5) Expression in Retinal Ganglion Cells.	EPHA6 EPHA5	4.58e-05	7	52	2	27402841
Pubmed	Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm.	LIG4 ABL1	4.58e-05	7	52	2	11040211
Pubmed	Growth hormone regulation of SIRP and SHP-2 tyrosyl phosphorylation and association.	JAK2 PTPN11	4.58e-05	7	52	2	9507023
Pubmed	Genome wide molecular analysis of minimally differentiated acute myeloid leukemia.	JAK2 PTPN11	4.58e-05	7	52	2	19773259
Pubmed	A new tyrosine-phosphorylated 97-kDa adaptor protein mediates interleukin-2-induced association of SHP-2 with p85-phosphatidylinositol 3-kinase in human T lymphocytes.	PTPN11 PIK3CA	4.58e-05	7	52	2	9660791
Pubmed	Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors.	JAK2 PTPN11	4.58e-05	7	52	2	14982882
Pubmed	Mistargeting hippocampal axons by expression of a truncated Eph receptor.	EPHA6 EPHA5	6.10e-05	8	52	2	12124402
Pubmed	Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping.	EPHA6 EPHA5	6.10e-05	8	52	2	10774725
Pubmed	Transcription factor Foxd1 is required for the specification of the temporal retina in mammals.	EPHA6 EPHA5	6.10e-05	8	52	2	21490208
Pubmed	Flow activates ERK1/2 and endothelial nitric oxide synthase via a pathway involving PECAM1, SHP2, and Tie2.	PTPN11 TEK	7.84e-05	9	52	2	15985432
Pubmed	Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins.	PTPN11 PIK3CA	7.84e-05	9	52	2	11353842
Pubmed	Abl kinases are required for vascular function, Tie2 expression, and angiopoietin-1-mediated survival.	ABL1 TEK	7.84e-05	9	52	2	23840065
Pubmed	Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis.	NEB TEK	7.84e-05	9	52	2	20018779
Pubmed	Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin.	JAK2 ABL1	7.84e-05	9	52	2	10455176
Pubmed	Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate.	EPHA6 EPHA5	9.79e-05	10	52	2	25073978
Pubmed	Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins.	JAK2 PTPN11	9.79e-05	10	52	2	9632636
Pubmed	Quantitative assessment of computational models for retinotopic map formation.	EPHA6 EPHA5	9.79e-05	10	52	2	25367067
Pubmed	EphrinA5 Signaling Is Required for the Distinctive Targeting of Raphe Serotonin Neurons in the Forebrain.	EPHA6 EPHA5	9.79e-05	10	52	2	28197551
Pubmed	HOXA13 directly regulates EphA6 and EphA7 expression in the genital tubercle vascular endothelia.	EPHA6 EPHA5	9.79e-05	10	52	2	17304517
Pubmed	Isolation of tyrosine kinase related genes expressed in the early hematopoietic system.	JAK2 TEK	9.79e-05	10	52	2	8034026
Pubmed	SHP2 and cbl participate in alpha-chemokine receptor CXCR4-mediated signaling pathways.	PTPN11 PIK3CA	9.79e-05	10	52	2	11157475
Pubmed	EphA receptors inhibit anti-CD3-induced apoptosis in thymocytes.	EPHA6 EPHA5	9.79e-05	10	52	2	16547242
Pubmed	Competition is a driving force in topographic mapping.	EPHA6 EPHA5	1.20e-04	11	52	2	22065784
Pubmed	Formation of persistent hyperplastic primary vitreous in ephrin-A5-/- mice.	EPHA6 EPHA5	1.20e-04	11	52	2	24550361
Pubmed	Selective inhibition of spinal cord neurite outgrowth and cell survival by the Eph family ligand ephrin-A5.	EPHA6 EPHA5	1.20e-04	11	52	2	10559410
Pubmed	Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.	JAK2 ABL1 PIK3CA	1.68e-04	71	52	3	28319113
Pubmed	ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia.	JAK2 PTPN11	1.69e-04	13	52	2	20880116
Pubmed	Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor.	PTPN11 PIK3CA	1.69e-04	13	52	2	27799550
Pubmed	Eph-ephrin A system regulates murine blastocyst attachment and spreading.	EPHA6 EPHA5	1.69e-04	13	52	2	17039519
Pubmed	EphA family gene expression in the developing mouse neocortex: regional patterns reveal intrinsic programs and extrinsic influence.	EPHA6 EPHA5	1.69e-04	13	52	2	12528186
Pubmed	Genetic linkage analysis of the Ak1, Col5a1, Epb7.2, Fpgs, Grp78, Pbx3, and Notch1 genes in the region of mouse chromosome 2 homologous to human chromosome 9q.	ABL1 FPGS	1.97e-04	14	52	2	8088777
Pubmed	Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue.	EPHA6 EPHA5	1.97e-04	14	52	2	26941654
Interaction	PIK3R1 interactions	HSCB JAK2 PTPN11 ABL1 PIK3CA TEK ADAM12 EPHA5	7.22e-06	412	50	8	int:PIK3R1
Cytoband	9q34.1	ABL1 FPGS	2.13e-04	19	52	2	9q34.1
Cytoband	4q26	NDST3 ARSJ	1.15e-03	44	52	2	4q26
Cytoband	Ensembl 112 genes in cytogenetic band chr4q26	NDST3 ARSJ	1.80e-03	55	52	2	chr4q26
Cytoband	Ensembl 112 genes in cytogenetic band chr9q34	ABL1 FPGS SOHLH1	6.01e-03	325	52	3	chr9q34
GeneFamily	Fibronectin type III domain containing	EPHA6 TEK PTPRT EPHA5	2.23e-04	160	34	4	555
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHA6 EPHA5	3.08e-04	14	34	2	1095
GeneFamily	SH2 domain containing	JAK2 PTPN11 ABL1	8.93e-04	101	34	3	741
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	HSCB DNAJC14	3.82e-03	49	34	2	584
GeneFamily	Sterile alpha motif domain containing	EPHA6 EPHA5	1.19e-02	88	34	2	760
Coexpression	JAIN_NFKB_SIGNALING	JAK2 LIG4 NAP1L1 ASCC3	1.40e-05	75	51	4	M17646
Coexpression	GSE6259_CD4_TCELL_VS_CD8_TCELL_UP	FLNC KYAT3 ADAM12 IL22RA1 GPRC5B	3.15e-05	187	51	5	M6738
Coexpression	GSE40685_TREG_VS_FOXP3_KO_TREG_PRECURSOR_UP	JAK2 GUCY1B1 BEAN1 PSMB9 AGBL2	4.24e-05	199	51	5	M9306
Coexpression	GSE42021_CD24HI_VS_CD24INT_TCONV_THYMUS_DN	PAPPA2 JAK2 LIG4 PSMB9 ARTN	4.35e-05	200	51	5	M9593
Coexpression	GSE360_L_MAJOR_VS_B_MALAYI_LOW_DOSE_DC_DN	FPGS DLEC1 ARTN ADAM12 GPRC5B	4.35e-05	200	51	5	M5212
ToppCell	PBMC-Severe-Hematopoietic-Platelet-Platelet-plt_5\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HGD GUCY1B1 NAP1L1 MFSD2B OAZ1	3.04e-06	193	52	5	a2fb7482e79d6ce5b6b1d9d0c0811d1c58b4d85d
ToppCell	PBMC-Severe-Hematopoietic-Platelet-Platelet-plt_5\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HGD GUCY1B1 NAP1L1 MFSD2B OAZ1	3.04e-06	193	52	5	1d724ccb745cfc624119dd6003d53b84b17c94b0
ToppCell	Endothelial-B-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	NDST3 FLNC BEAN1 GPRC5B	4.21e-05	166	52	4	c286987ea4e511195607c87ec4529c2c2ed2122e
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D122\|Adult / Lineage, Cell type, age group and donor	WNT9B TEK IL22RA1 GPRC5B	4.42e-05	168	52	4	8c3e1e45b422813bcdfa4273b1167db649a312f5
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARSJ EPHA6 PTPRT EPHA5	5.65e-05	179	52	4	c815eb9f760fe4ca7a5e49beb224659f0b864f22
ToppCell	LPS-IL1RA\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	JAK2 PTPN11 ASCC3 TEK	6.29e-05	184	52	4	c066c2ec4f0f1d6eb183fca5c7bb0cd45c9950dc
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARSJ DLEC1 AGBL2 TEK	6.29e-05	184	52	4	f506d0ee48f39d6f59f19554217dfdf0987cc405
ToppCell	droplet-Lung-30m-Endothelial-arterial_endothelial\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARSJ DLEC1 AGBL2 TEK	6.29e-05	184	52	4	8bcb1c4bc8ffef74338cdade926a94711de93c64
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet-plt_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HGD GUCY1B1 MFSD2B OAZ1	6.42e-05	185	52	4	0a2c8ce92a257d0ec5bcc8efa22792d53752c665
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet-plt_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HGD GUCY1B1 MFSD2B OAZ1	6.56e-05	186	52	4	4a9b5b3a56229629161d5404db2b8dd76e10cf4b
ToppCell	severe-Others\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	HGD GUCY1B1 NAP1L1 MFSD2B	6.56e-05	186	52	4	234a4bc7c3529daf8804f2a366887d02a47075cd
ToppCell	Adult-Endothelial-endothelial_cell_of_artery\|Adult / Lineage, Cell type, age group and donor	WNT9B TEK IL22RA1 GPRC5B	6.56e-05	186	52	4	2d1c4ea2e401db89971582ee54618a8b0c81b8ac
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HGD ANPEP COBL PTPRT	6.56e-05	186	52	4	b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCell	severe-Others-Megakaryocytes\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	HGD GUCY1B1 NAP1L1 MFSD2B	6.69e-05	187	52	4	ef16331d1e5abe6bde7f09793c4a87a6ac24e592
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1\|Adult / Lineage, Cell type, age group and donor	ARSJ COBL PEAK1 GLCCI1	6.69e-05	187	52	4	77f78aec946bc6bd85c29aee9ca978ce49f853a3
ToppCell	severe_influenza-Platelet\|World / disease group, cell group and cell class (v2)	HGD GUCY1B1 MFSD2B OAZ1	6.83e-05	188	52	4	b54632baa682aaf51100d44e7f114a54d5edd695
ToppCell	PBMC-Severe-Hematopoietic-Platelet-Platelet-plt_3\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HGD GUCY1B1 NAP1L1 OAZ1	6.98e-05	189	52	4	d357fa946b9d6af46c15402f68758fb9c747bcaf
ToppCell	PBMC-Severe-Hematopoietic-Platelet-Platelet-plt_3\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HGD GUCY1B1 NAP1L1 OAZ1	6.98e-05	189	52	4	8b4a9434d7b7ca8cf74712227407ed7c96ce02f8
ToppCell	COVID-19_Severe-Hematopoietic_Mega-Platelet\|COVID-19_Severe / Disease group, lineage and cell class	HGD GUCY1B1 NAP1L1 OAZ1	7.41e-05	192	52	4	6ebdb70cc0292e41b348d38d89f77e9a3b029bd8
ToppCell	COVID-19_Severe-Hematopoietic_Mega\|COVID-19_Severe / Disease group, lineage and cell class	HGD GUCY1B1 NAP1L1 OAZ1	7.41e-05	192	52	4	2764c3c68982077a448ff5da58344e0f6cec0a52
ToppCell	367C-Myeloid-Dendritic-cDC1\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	ABL1 ANPEP NAP1L1 PSMB9	7.87e-05	195	52	4	fca958f73de450ef813444d3dc590353f1c55326
ToppCell	Control_saline-Hematopoietic_Erythro-Megakary-Erythro-Mega-Platelets\|Control_saline / Treatment groups by lineage, cell group, cell type	JAK2 HGD MFSD2B OAZ1	8.51e-05	199	52	4	86d4e5dd3bcc6bafa48fd0211dad39a2456b53be
ToppCell	LPS_anti-TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega-Platelets\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	HGD NAP1L1 MFSD2B OAZ1	8.68e-05	200	52	4	e4be88bcef2738915f711b32c95e9c613e7edf96
ToppCell	LPS_IL1RA-Hematopoietic_Erythro-Megakary-Erythro-Mega-Platelets\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	HGD NAP1L1 MFSD2B OAZ1	8.68e-05	200	52	4	326cae37cacd94b423a6ac8873ea56c5abaf0a0b
ToppCell	10x5'v1-week_17-19-Lymphocytic_B-B_lineage\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	UBE2I FPGS NAP1L1 PSMB9	8.68e-05	200	52	4	c28d4ca51d2e2a3a22784ee251975f16a55b0297
ToppCell	10x5'v1-week_17-19-Lymphocytic_B\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	UBE2I FPGS NAP1L1 PSMB9	8.68e-05	200	52	4	364f09eb9ae4913f5c80a29e943e1c0b2ffd5f93
Drug	EKB-569	JAK2 ABL1 EPHA6 TEK EPHA5	1.64e-06	87	52	5	CID006445562
Drug	Ethambutol dihydrochloride [1070-11-7]; Up 200; 14.4uM; PC3; HG-U133A	UBE2I GUCY1B1 BEAN1 FPGS NAP1L1 PRDM2	5.85e-06	198	52	6	1900_UP
Drug	sunitinib	JAK2 ABL1 EPHA6 TEK EPHA5	1.18e-05	130	52	5	CID005329102
Drug	BIRB796	ABL1 EPHA6 TEK EPHA5	1.57e-05	66	52	4	CID000156422
Drug	ponatinib	JAK2 ABL1 TEK EPHA5	1.77e-05	68	52	4	ctd:C545373
Disease	colorectal cancer (is_implicated_in)	LIG4 MAP2K4 ABL1 PIK3CA PTPRT	1.76e-06	121	49	5	DOID:9256 (is_implicated_in)
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	JAK2 LIG4 ABL1 FPGS	3.27e-06	61	49	4	C1961102
Disease	Ovarian Serous Adenocarcinoma	JAK2 MAP2K4 TEK	7.45e-06	23	49	3	C1335177
Disease	nitric oxide exhalation measurement	PAPPA2 DLEC1 PTPRT	3.48e-05	38	49	3	EFO_0005536
Disease	Solid Neoplasm	PTPN11 PIK3CA	5.64e-05	7	49	2	C0280100
Disease	leukemia	JAK2 LIG4 PTPN11	1.06e-04	55	49	3	C0023418
Disease	intraocular pressure measurement	KLHL38 ANPEP WNT9B DLEC1 ADAM12 GLCCI1	1.91e-04	509	49	6	EFO_0004695
Disease	hematologic cancer (implicated_via_orthology)	JAK2 UBE2I	2.08e-04	13	49	2	DOID:2531 (implicated_via_orthology)
Disease	stomach cancer (is_implicated_in)	JAK2 PTPN11 PIK3CA	2.37e-04	72	49	3	DOID:10534 (is_implicated_in)
Disease	acute myeloid leukemia (is_implicated_in)	JAK2 ABL1 DLEC1	3.73e-04	84	49	3	DOID:9119 (is_implicated_in)
Disease	ankylosing spondylitis (is_implicated_in)	JAK2 PSMB9	4.54e-04	19	49	2	DOID:7147 (is_implicated_in)
Disease	sensory peripheral neuropathy, remission	DLEC1 PTPRT	6.68e-04	23	49	2	EFO_0009785, MONDO_0002321
Disease	Major Depressive Disorder	SRRT ANPEP KYAT3 ARTN	7.11e-04	243	49	4	C1269683
Disease	hepatocellular carcinoma (biomarker_via_orthology)	JAK2 PIK3CA TEK	7.77e-04	108	49	3	DOID:684 (biomarker_via_orthology)
Disease	colon adenocarcinoma (is_implicated_in)	JAK2 PIK3CA	8.56e-04	26	49	2	DOID:234 (is_implicated_in)
Disease	pancreatic cancer (is_implicated_in)	LIG4 MAP2K4 NAP1L1	8.64e-04	112	49	3	DOID:1793 (is_implicated_in)
Disease	Unipolar Depression	SRRT ANPEP KYAT3 ARTN	9.01e-04	259	49	4	C0041696
Disease	Carcinoma, Granular Cell	PTPN11 ABL1 PIK3CA	9.56e-04	116	49	3	C0205644
Disease	Adenocarcinoma, Tubular	PTPN11 ABL1 PIK3CA	9.56e-04	116	49	3	C0205645
Disease	Adenocarcinoma, Oxyphilic	PTPN11 ABL1 PIK3CA	9.56e-04	116	49	3	C0205642
Disease	Carcinoma, Cribriform	PTPN11 ABL1 PIK3CA	9.56e-04	116	49	3	C0205643
Disease	Adenocarcinoma, Basal Cell	PTPN11 ABL1 PIK3CA	9.56e-04	116	49	3	C0205641
Disease	Adenocarcinoma	PTPN11 ABL1 PIK3CA	9.56e-04	116	49	3	C0001418
Disease	Myeloid Leukemia, Chronic	JAK2 ABL1	1.07e-03	29	49	2	C0023473
Disease	gas trapping measurement	TAS1R2 DLEC1	1.07e-03	29	49	2	EFO_0007628
Disease	Large cell carcinoma of lung	ABL1 EPHA5	1.30e-03	32	49	2	C0345958
Disease	Squamous cell carcinoma of lung	MAP2K4 EPHA5	1.30e-03	32	49	2	C0149782
Disease	peak expiratory flow	NDST3 PAPPA2 LIG4 DLEC1 AGBL2	1.39e-03	498	49	5	EFO_0009718
Disease	anti-GAD65 autoimmune neurological syndromes	SRRT MAP2K4	1.55e-03	35	49	2	EFO_0803379
Disease	gestational age	KLHL38 MAP2K4 DLEC1	1.58e-03	138	49	3	EFO_0005112
Disease	oppositional defiant disorder measurement	LIG4 ADAM12	1.64e-03	36	49	2	EFO_0007679

Protein segments in the cluster

Peptide	Gene	Start	Entry
DYFRRESDPPTMACT	EPHA5	341	P54756
YPFPMVFSSCSRKDL	ADAM12	386	O43184
NSYMFKREPPEGCER	GLCCI1	411	Q86VQ1
DARKSFPCFDEPAMK	ANPEP	216	P15144
DSIAKTRDAGCRPYM	MAP2K4	256	P45985
RKYPPMDSDSRTFLS	NDST3	826	O95803
FCMYVRPPSEKSVEE	OR5M10	256	Q6IEU7
NCMDYEPDFRPSFRA	JAK2	786	O60674
KTYRMRSEPDDSDPF	NAP1L1	231	P55209
RFEMDREPKSARYCA	DNAJC14	546	Q6Y2X3
FYRKECMPTRRGFDT	ARSJ	181	Q5FYB0
PCCRPTRYEAVSFMD	ARTN	186	Q5T4W7
SSEKPAIVFMYRCDP	PEAK1	981	Q9H792
KGDSTFRCTYRPAME	FLNC	431	Q14315
TPCPRERDSATAYRM	MFSD2B	171	A6NFX1
IYPGMRAPSFRCTDA	GUCY1B1	111	Q02153
TPPCAEMREDSARVY	PTPN11	566	Q06124
AYKPGMSPEECRRFT	PSMB9	161	P28065
DMAAAYFPDCIVRPF	MTPAP	216	Q9NVV4
PKRPDACFMAYTFER	OAZ1	206	P54368
QLPMDCFTMPSYSRR	PIK3CA	296	P42336
RTCDPVEMSYPRDQF	PTPRT	851	O14522
LRDTRPACAYEPMDF	GPRC5B	186	Q9NZH0
CFDPDSPKRAYMSVK	PAPPA2	656	Q9BXP8
PSDMYKTGCTLRFPR	LIG4	566	P49917
MTPGFRKEDVYSCFR	GNPAT	501	O15228
IPPKSEMRCYDRDVS	COBL	711	O75128
KKFANPSRYRMECPE	IFIT1B	126	Q5T764
YRMERPEGCPEKVYE	ABL1	456	P00519
PRSRYPATKRGCAAM	AGBL2	876	Q5U5Z8
SPYSMDDRDPRKFFM	FAM166B	166	A8MTA8
ESAPYMCRVKTLPDR	IL22RA1	211	Q8N6P7
TKDGSCVSMPPYFRF	FPGS	166	Q05932
MSFKRPCPLARYNRT	BEAN1	1	Q3B7T3
CYPDKETAFSIMPRK	DLEC1	671	Q9Y238
RMDDPECYFNSLPKE	KYAT3	331	Q6YP21
ERETVSPPCFDEYKM	PRDM2	791	Q13029
DKTFRPPYYHRNCMS	HGD	326	Q93099
YFRAEKDPPSMACTR	EPHA6	316	Q9UF33
APDPTRDYFSLMDCN	HSCB	66	Q8IWL3
MASRCSEPYPEVSRI	SOHLH1	1	Q5JUK2
FCMYVRPPSEKSVEE	OR5M1	256	Q8NGP8
PLASRYASPEMCFVF	ADSL	16	P30566
CKRYPGFMRVALSEP	SRRT	441	Q9BXP5
RAMLPCPDYDTDTKT	ASCC3	1901	Q8N3C0
RMLFKDDYPSSPPKC	UBE2I	61	P63279
MRQCWREKPYERPSF	TEK	1071	Q02763
SPFVLMSCDPSVYRF	VN1R4	281	Q7Z5H5
VCAFKMASRFPRAYS	TAS1R2	656	Q8TE23
LVYMEDSPSFCRPSK	WNT9B	281	O14905
RDSESSKPSFMPRLY	HECTD3	461	Q5T447
EARDMYVPNPSCRDF	HECTD3	581	Q5T447
SPYFRAMFCSSFREK	KLHL38	56	Q2WGJ6
FGCFLYDTPDMVRSR	NEB	5101	P20929