Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainLDLR_class-A_CS

LRP2 TMPRSS2

1.41e-0340262IPR023415
Domain-

LRP2 TMPRSS2

1.86e-03462624.10.400.10
DomainLDLRA_1

LRP2 TMPRSS2

2.02e-0348262PS01209
DomainLDrepeatLR_classA_rpt

LRP2 TMPRSS2

2.11e-0349262IPR002172
DomainLDLa

LRP2 TMPRSS2

2.11e-0349262SM00192
DomainLDLRA_2

LRP2 TMPRSS2

2.11e-0349262PS50068
Pubmed

Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization.

PDGFRA SHB

6.25e-07228210837138
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DAB1 TMPRSS2 SLITRK3 IGSF9B SLC38A9 CLMN ZMYM4 FRMPD2 SHB

1.56e-06148928928611215
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

LRP2 CRYL1 ZSWIM8 ALKBH6 VPS39 MED13 ZMYM4 ZMYND8

5.46e-06128528835914814
Pubmed

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.

DAB1 LRP2

9.36e-0662829837937
Pubmed

The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.

DAB1 LRP2

1.31e-05728212169628
Pubmed

The Secreted Glycoprotein Reelin Suppresses the Proliferation and Regulates the Distribution of Oligodendrocyte Progenitor Cells in the Embryonic Neocortex.

DAB1 PDGFRA

1.31e-05728232913108
Pubmed

Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule.

DAB1 LRP2

4.85e-051328212508107
Pubmed

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.

DAB1 LRP2

9.49e-051828210827173
Pubmed

Ectopic clustering of Cajal-Retzius and subplate cells is an initial pathological feature in Pomgnt2-knockout mice, a model of dystroglycanopathy.

DAB1 POMGNT2

1.71e-042428226060116
Pubmed

Jmjd2c facilitates the assembly of essential enhancer-protein complexes at the onset of embryonic stem cell differentiation.

LRP2 PDGFRA

2.01e-042628228087629
Pubmed

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.

CTDSPL2 ZMYND8

4.78e-044028228805822
Pubmed

The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state.

DAB1 PDGFRA

4.78e-044028226657772
Pubmed

Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways.

CRYL1 PDGFRA CLMN

5.28e-0419728321386911
Pubmed

Prospective isolation and global gene expression analysis of definitive and visceral endoderm.

TMPRSS2 PDGFRA

6.33e-044628217328885
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

CLMN MED13 ZMYM4 SHB

6.43e-0449728423414517
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

ZSWIM8 CTDSPL2 SLC38A9 ZMYND8 ALG13

7.78e-0492528528986522
CytobandEnsembl 112 genes in cytogenetic band chr15q15

CTDSPL2 VPS39

3.64e-03147282chr15q15
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

IGSF9B PDGFRA

1.10e-02161182593
CoexpressionAtlasDevelopingLowerUrinaryTract_e15.5_Urothelium_emap-28091_k-means-cluster#1_top-relative-expression-ranked_1000

DAB1 LRP2 SLC38A9 MED13

7.48e-05173284gudmap_developingLowerUrinaryTract_e15.5_Urothelium_1000_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#3_top-relative-expression-ranked_1000

DAB1 PDGFRA DCBLD2 MED13 ZMYM4

1.09e-04369285DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k3_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#5_top-relative-expression-ranked_500

DAB1 PDGFRA DCBLD2 MED13

1.16e-04194284DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k5_500
ToppCellE16.5-samps-Epithelial-Alveolar_epithelial_precursor-Noncycling_AT2_Precursor|E16.5-samps / Age Group, Lineage, Cell class and subclass

LRP2 TMPRSS2 CLMN SHB

2.60e-061552849cad73d0b8ead289e1073d1a2e00bbeb1228308c
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TMPRSS2 ZSWIM8 SHB

1.21e-04154283ba55a63cfa5e0fb9dfec794f80078a2f0d03d0ad
ToppCellfacs-Pancreas-Exocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLITRK3 CTDSPL2 ZMYM4

1.43e-04163283953a7db7e90a913e81002d2141fbbd5f1fdf2197
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP2 SLITRK3 IGSF9B

1.46e-041642833caf4cdaa0164907893fea61e251fd8b5fa926e4
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

DAB1 IGSF9B ALG13

1.54e-041672834b6853efefea5178280ba7c31facda0fbd1cc469
ToppCellInt-URO-Lymphocyte-T_NK-MAIT|Int-URO / Disease, Lineage and Cell Type

DAB1 IGSF9B DCBLD2

1.73e-041742835227ed29f5f0d3e0aaa7f3cfd362f96d3e2660f7
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAB1 SLITRK3 IGSF9B

1.98e-0418228382ca6d5ed48b4c487ce00b9309255abb8f20b61d
ToppCelldroplet-Limb_Muscle-nan-21m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DAB1 SLITRK3 IGSF9B

1.98e-04182283a512863304fad80acaab60a8c6107eb7c9cbac99
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-skeletal_muscle_satellite_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 CLMN VGLL2

2.08e-041852835414a66169c39d09a67b1050aad5e61f46b3749a
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D231|Adult / Lineage, Cell type, age group and donor

LRP2 TMPRSS2 DCBLD2

2.21e-04189283dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCellAT2_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

LRP2 TMPRSS2 DCBLD2

2.21e-041892832d32f09efa982ae458568f6b1cd06bb5078d42a3
ToppCellPND14-Epithelial|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 TMPRSS2 CLMN

2.25e-04190283f1eeef8f201bf7b96c020c8ab53dd7e05b3060ea
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRP2 PDGFRA CLMN

2.28e-041912832110a1dd10730ad7ee7a265fb1716ab3ddafcf4a
ToppCellCOVID-19-lung-AT2|lung / Disease (COVID-19 only), tissue and cell type

LRP2 TMPRSS2 DCBLD2

2.28e-04191283276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2|Adult / Lineage, Cell type, age group and donor

LRP2 TMPRSS2 DCBLD2

2.35e-04193283738f4f0a9ddde2432b429ab46838e353b1790589
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP2 CRYL1 CLMN

2.35e-0419328382e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCellfacs-Thymus-Thymus_Epithelium|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 PDGFRA RHOJ

2.46e-041962836bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DAB1 IGSF9B PDGFRA

2.46e-04196283671c380b58d7f634b4fbec38c357d357ea4f3535
ToppCellfacs-Thymus-Thymus_Epithelium-18m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 PDGFRA RHOJ

2.46e-04196283c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DAB1 IGSF9B PDGFRA

2.46e-04196283f374cb3ec31c6eef2cef9e07547bfd1e380553af
ToppCellMesenchymal_cells-Myofibroblasts|World / Lineage and Cell class

RHOJ CLMN VGLL2

2.46e-041962832c0f429ae18c2df05c33ddf58dcc2c94b819b9a1
ToppCelldistal-Epithelial-Alveolar_Epithelial_Type_2-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LRP2 TMPRSS2 DCBLD2

2.54e-0419828319eefd05573fbaed654af52bf0f8a26092b8b229
ToppCellmedial-2-Epithelial-Alveolar_Epithelial_Type_2|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LRP2 TMPRSS2 DCBLD2

2.54e-04198283102a4cbb138adbfba11ed955420095daa098532f
ToppCell(5)_Dendritic_cell-(53)_Lymphoid_DC|(5)_Dendritic_cell / shred on Cell_type and subtype

DAB1 PDGFRA RHOJ

2.54e-04198283548da5fa86f9756c503ed77bcdde55bc4d1a2726
ToppCellmLN-(5)_Dendritic_cell-(53)_Lymphoid_DC|mLN / shred on region, Cell_type, and subtype

DAB1 PDGFRA RHOJ

2.54e-04198283da84c76afe835aeee39da04b63c03549218b5d91
ToppCellmedial-Epithelial-Alveolar_Epithelial_Type_2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LRP2 TMPRSS2 DCBLD2

2.54e-0419828353e5d76831d70b9a476f3ef3a81e13eda974d543
ToppCellmLN-Dendritic_cell-Lymphoid_DC|mLN / Region, Cell class and subclass

DAB1 PDGFRA RHOJ

2.54e-041982833965a9f1e8a51a196e5349aaca5fa5ed1cd8ee92
ToppCellmedial-Epithelial-Alveolar_Epithelial_Type_2-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LRP2 TMPRSS2 DCBLD2

2.54e-041982837caeed2d5dc78866023c8f38edcec9886baa9f2c
ToppCelldistal-1-Epithelial-Alveolar_Epithelial_Type_2|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LRP2 TMPRSS2 DCBLD2

2.54e-04198283ce9d6b2a93c7b304414ce1b8b1a09562cf581278
ToppCellBiopsy_Other_PF-Epithelial-AT2|Biopsy_Other_PF / Sample group, Lineage and Cell type

LRP2 TMPRSS2 DCBLD2

2.57e-041992839a65acfe9bf500db72142469cf17bf0973540001
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DAB1 SLITRK3 PDGFRA

2.57e-04199283333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DAB1 SLITRK3 PDGFRA

2.57e-04199283e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DAB1 SLITRK3 PDGFRA

2.61e-04200283ad777683adeb2ce45ade570386235e311fa7ea2d
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Macroglial-Astrocyte|GW16 / Sample Type, Dataset, Time_group, and Cell type.

CRYL1 PDGFRA RHOJ

2.61e-042002837205e742ad796d548761839d92a4794ee8f17629
ToppCellSepsis-Int-URO-Lymphocyte-T/NK-MAIT|Int-URO / Disease, condition lineage and cell class

DAB1 IGSF9B DCBLD2

2.61e-04200283043c18e79a969e37bbff86443e553ac09fe33f84
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Macroglial|GW16 / Sample Type, Dataset, Time_group, and Cell type.

CRYL1 PDGFRA RHOJ

2.61e-0420028325b573f4427ecafe050ca90bea459f1b25b451cf
ToppCell(53)_Lymphoid_DC|World / shred on Cell_type and subtype

DAB1 PDGFRA RHOJ

2.93e-0420828330212cfacad94a7cc562a69efa73a31259851515
DiseaseProteinuria

LRP2 CRYL1

8.40e-0515272HP_0000093
DiseaseIntellectual Disability

LRP2 MED13 ALG13

7.71e-03447273C3714756
DiseaseCraniofacial Abnormalities

LRP2 PDGFRA

8.94e-03156272C0376634
DiseaseMalignant tumor of colon

RHOJ RAD54B

9.27e-03159272C0007102

Protein segments in the cluster

PeptideGeneStartEntry
VEQAPPVIYYVPDFI

ALKBH6

16

Q3KRA9
LHVENYPVYTEPPLV

ALG13

1011

Q9NP73
DPYYFIKHVPPLTEE

CTDSPL2

256

Q05D32
AFVEVLVEPHHPYIY

DNHD1

2396

Q96M86
PQTEFALAVYIHPYP

CC2D2B

1406

Q6DHV5
FPLVDVVIDPYLVYH

RAD54B

281

Q9Y620
HIYIYVPDPDVAFVP

PDGFRA

116

P16234
PFDIHVYHPYRQPIV

LRP2

3451

P98164
VVELFPYAVNPDHYT

POMGNT2

361

Q8NAT1
FPEEYVPTVFDHYAV

RHOJ

46

Q9H4E5
HTPVPAPDFLFEIEY

PARP16

116

Q8N5Y8
PVYQYIVFEAGHEPI

DAB1

196

O75553
QVESKPYFHVEDYIP

FRMPD2

486

Q68DX3
YYIPLVELVPHPETA

CRYL1

151

Q9Y2S2
EVYHAYAEPLPITGP

DCBLD2

661

Q96PD2
PVPLEQHPDYAEYIF

ZMYND8

176

Q9ULU4
DHVVPAPEECYVYSP

SLC38A9

86

Q8NBW4
PVPISIPEVYEHFFF

PERM1

651

Q5SV97
NSPPFDSVPEVIHYY

SHB

471

Q15464
EKAPPVGHVYEYIPH

SLITRK3

731

O94933
PPAIVVYIIDPFTYE

MED13

1636

Q9UHV7
VIPHDLFYFPHYEVP

CLMN

721

Q96JQ2
YPAQPTVVPTVYEVH

TMPRSS2

26

O15393
YPRPAAVHEVYAPHF

VGLL2

221

Q8N8G2
IFIKFGYYPPHVDPE

IGSF9B

71

Q9UPX0
FHIPFEVVEKVYPPV

ZSWIM8

86

A7E2V4
VPVFVPIPLHLYTQY

ZMYM4

986

Q5VZL5
EHQPPYIIAVLPRYV

VPS39

251

Q96JC1