Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	GLUD1 GLUD2	6.30e-05	2	159	2	GO:0016639
GeneOntologyMolecularFunction	glutamate dehydrogenase [NAD(P)+] activity	GLUD1 GLUD2	6.30e-05	2	159	2	GO:0004353
GeneOntologyMolecularFunction	glutamate dehydrogenase (NAD+) activity	GLUD1 GLUD2	6.30e-05	2	159	2	GO:0004352
GeneOntologyMolecularFunction	glutamate dehydrogenase (NADP+) activity	GLUD1 GLUD2	6.30e-05	2	159	2	GO:0004354
GeneOntologyMolecularFunction	serine-type peptidase activity	KLK15 PRSS12 RBP3 C1RL GZMB GZMK KLK8 MASP2	2.59e-04	207	159	8	GO:0008236
GeneOntologyMolecularFunction	serine hydrolase activity	KLK15 PRSS12 RBP3 C1RL GZMB GZMK KLK8 MASP2	3.05e-04	212	159	8	GO:0017171
GeneOntologyMolecularFunction	ribose phosphate diphosphokinase activity	PRPS2 PRPS1L1	6.20e-04	5	159	2	GO:0004749
Domain	Sushi_SCR_CCP_dom	SELP C1RL APOH CSMD2 CSMD3 SVEP1 CSMD1 MASP2	2.43e-08	57	157	8	IPR000436
Domain	Sushi	SELP APOH CSMD2 CSMD3 SVEP1 CSMD1 MASP2	2.53e-07	52	157	7	PF00084
Domain	CCP	SELP APOH CSMD2 CSMD3 SVEP1 CSMD1 MASP2	3.30e-07	54	157	7	SM00032
Domain	SUSHI	SELP APOH CSMD2 CSMD3 SVEP1 CSMD1 MASP2	4.26e-07	56	157	7	PS50923
Domain	TILa_dom	ZAN TECTA FCGBP	5.83e-07	3	157	3	IPR025615
Domain	TILa	ZAN TECTA FCGBP	5.83e-07	3	157	3	PF12714
Domain	C8	ZAN TECTA FCGBP MUC6	2.26e-06	12	157	4	PF08742
Domain	TIL	ZAN TECTA FCGBP MUC6	2.26e-06	12	157	4	PF01826
Domain	Unchr_dom_Cys-rich	ZAN TECTA FCGBP MUC6	3.24e-06	13	157	4	IPR014853
Domain	C8	ZAN TECTA FCGBP MUC6	3.24e-06	13	157	4	SM00832
Domain	CUB	C1RL CSMD2 CSMD3 NRP2 CSMD1 MASP2	3.33e-06	49	157	6	PF00431
Domain	CUB	C1RL CSMD2 CSMD3 NRP2 CSMD1 MASP2	3.75e-06	50	157	6	SM00042
Domain	TIL_dom	ZAN TECTA FCGBP MUC6	4.50e-06	14	157	4	IPR002919
Domain	-	C1RL CSMD2 CSMD3 NRP2 CSMD1 MASP2	4.74e-06	52	157	6	2.60.120.290
Domain	EGF	SELP ZAN ADAM9 TECTA ADAM28 SVEP1 GPR179 FCGBP EGF ADGRE1 MASP2	4.94e-06	235	157	11	SM00181
Domain	CUB	C1RL CSMD2 CSMD3 NRP2 CSMD1 MASP2	5.31e-06	53	157	6	PS01180
Domain	VWF_type-D	ZAN TECTA FCGBP MUC6	8.08e-06	16	157	4	IPR001846
Domain	VWFD	ZAN TECTA FCGBP MUC6	8.08e-06	16	157	4	PS51233
Domain	VWD	ZAN TECTA FCGBP MUC6	8.08e-06	16	157	4	SM00216
Domain	VWD	ZAN TECTA FCGBP MUC6	8.08e-06	16	157	4	PF00094
Domain	CUB_dom	C1RL CSMD2 CSMD3 NRP2 CSMD1 MASP2	8.17e-06	57	157	6	IPR000859
Domain	WD40_repeat_dom	CFAP251 RAE1 ARPC1A UBR4 CDC20B NOL11 WSB2 WDFY4 WDR59 WDR73 ELP2 EIF3I	8.19e-06	297	157	12	IPR017986
Domain	VWC_out	ZAN TECTA FCGBP MUC6	1.69e-05	19	157	4	SM00215
Domain	WD40	CFAP251 RAE1 ARPC1A CDC20B WSB2 NUP214 WDFY4 WDR59 WDR73 ELP2 EIF3I	1.70e-05	268	157	11	SM00320
Domain	WD40_repeat	CFAP251 RAE1 ARPC1A CDC20B WSB2 NUP214 WDFY4 WDR59 WDR73 ELP2 EIF3I	1.96e-05	272	157	11	IPR001680
Domain	-	CFAP251 RAE1 ARPC1A CDC20B NOL11 WSB2 NUP214 WDFY4 WDR59 WDR73 ELP2 EIF3I	2.56e-05	333	157	12	2.130.10.10
Domain	TRYPSIN_HIS	KLK15 PRSS12 C1RL GZMB GZMK KLK8 MASP2	2.62e-05	103	157	7	IPR018114
Domain	WD40/YVTN_repeat-like_dom	CFAP251 RAE1 ARPC1A CDC20B NOL11 WSB2 NUP214 WDFY4 WDR59 WDR73 ELP2 EIF3I	2.71e-05	335	157	12	IPR015943
Domain	TRYPSIN_SER	KLK15 PRSS12 C1RL GZMB GZMK KLK8 MASP2	3.15e-05	106	157	7	PS00135
Domain	TRYPSIN_HIS	KLK15 PRSS12 C1RL GZMB GZMK KLK8 MASP2	3.35e-05	107	157	7	PS00134
Domain	Peptidase_S1A	KLK15 PRSS12 C1RL GZMB GZMK KLK8 MASP2	4.75e-05	113	157	7	IPR001314
Domain	EGF-like_dom	SELP ZAN ADAM9 TECTA ADAM28 SVEP1 FCGBP EGF ADGRE1 MASP2	4.99e-05	249	157	10	IPR000742
Domain	TRYPSIN_DOM	KLK15 PRSS12 C1RL GZMB GZMK KLK8 MASP2	5.32e-05	115	157	7	PS50240
Domain	Tryp_SPc	KLK15 PRSS12 C1RL GZMB GZMK KLK8 MASP2	5.94e-05	117	157	7	SM00020
Domain	WD40	CFAP251 RAE1 ARPC1A CDC20B WSB2 WDFY4 WDR59 WDR73 ELP2 EIF3I	6.94e-05	259	157	10	PF00400
Domain	ELFV_dehydrog_N	GLUD1 GLUD2	7.02e-05	2	157	2	PF02812
Domain	Glu/Leu/Phe/Val_DH_C	GLUD1 GLUD2	7.02e-05	2	157	2	IPR006096
Domain	Glu/Leu/Phe/Val_DH_dimer_dom	GLUD1 GLUD2	7.02e-05	2	157	2	IPR006097
Domain	Glu/Leu/Phe/Val_DH	GLUD1 GLUD2	7.02e-05	2	157	2	IPR006095
Domain	ELFV_dehydrog	GLUD1 GLUD2	7.02e-05	2	157	2	PF00208
Domain	NAD_bind_Glu_DH	GLUD1 GLUD2	7.02e-05	2	157	2	IPR033922
Domain	GLFV_DEHYDROGENASE	GLUD1 GLUD2	7.02e-05	2	157	2	PS00074
Domain	DVL-1	DVL1P1 DVL1	7.02e-05	2	157	2	IPR008340
Domain	ELFV_dehydrog	GLUD1 GLUD2	7.02e-05	2	157	2	SM00839
Domain	Glu/Leu/Phe/Val_DH_AS	GLUD1 GLUD2	7.02e-05	2	157	2	IPR033524
Domain	Trypsin_dom	KLK15 PRSS12 C1RL GZMB GZMK KLK8 MASP2	7.35e-05	121	157	7	IPR001254
Domain	Trypsin	KLK15 PRSS12 C1RL GZMB GZMK KLK8 MASP2	7.35e-05	121	157	7	PF00089
Domain	Peptidase_S1_PA	KLK15 PRSS12 C1RL GZMB GZMK KLK8 MASP2	8.15e-05	123	157	7	IPR009003
Domain	TRYPSIN_SER	PRSS12 C1RL GZMB GZMK KLK8 MASP2	1.12e-04	90	157	6	IPR033116
Domain	WD_REPEATS_1	CFAP251 RAE1 ARPC1A CDC20B WSB2 WDFY4 WDR59 WDR73 ELP2 EIF3I	1.25e-04	278	157	10	PS00678
Domain	WD_REPEATS_2	CFAP251 RAE1 ARPC1A CDC20B WSB2 WDFY4 WDR59 WDR73 ELP2 EIF3I	1.28e-04	279	157	10	PS50082
Domain	WD_REPEATS_REGION	CFAP251 RAE1 ARPC1A CDC20B WSB2 WDFY4 WDR59 WDR73 ELP2 EIF3I	1.28e-04	279	157	10	PS50294
Domain	PRPP_SYNTHASE	PRPS2 PRPS1L1	2.09e-04	3	157	2	PS00114
Domain	TEX13	TEX13B TEX13A	2.09e-04	3	157	2	PF15186
Domain	TEX13	TEX13B TEX13A	2.09e-04	3	157	2	IPR028193
Domain	PRib_PP_synth_CS	PRPS2 PRPS1L1	2.09e-04	3	157	2	IPR000842
Domain	EGF_1	SELP ZAN ADAM9 ITGB4 ADAM28 SVEP1 EGF ADGRE1 MASP2	3.13e-04	255	157	9	PS00022
Domain	EGF-like_CS	SELP ZAN ADAM9 ITGB4 ADAM28 SVEP1 EGF ADGRE1 MASP2	3.71e-04	261	157	9	IPR013032
Domain	EGF_2	SELP ZAN ADAM9 ITGB4 ADAM28 SVEP1 EGF ADGRE1 MASP2	4.15e-04	265	157	9	PS01186
Domain	Dishevelled	DVL1P1 DVL1	4.17e-04	4	157	2	PF02377
Domain	COE	EBF3 EBF2	4.17e-04	4	157	2	PS01345
Domain	Transcription_factor_COE	EBF3 EBF2	4.17e-04	4	157	2	IPR003523
Domain	COE_HLH	EBF3 EBF2	4.17e-04	4	157	2	IPR032201
Domain	COE_DBD	EBF3 EBF2	4.17e-04	4	157	2	IPR032200
Domain	Dishevelled_fam	DVL1P1 DVL1	4.17e-04	4	157	2	IPR008339
Domain	Transcription_factor_COE_CS	EBF3 EBF2	4.17e-04	4	157	2	IPR018350
Domain	COE1_HLH	EBF3 EBF2	4.17e-04	4	157	2	PF16423
Domain	COE1_DBD	EBF3 EBF2	4.17e-04	4	157	2	PF16422
Domain	Dishevelled_protein_dom	DVL1P1 DVL1	4.17e-04	4	157	2	IPR003351
Domain	VWF_dom	ZAN TECTA FCGBP MUC6	4.19e-04	42	157	4	IPR001007
Domain	PLAC	THSD4 ADAMTSL1 ADAMTS3	5.11e-04	19	157	3	PS50900
Domain	PLAC	THSD4 ADAMTSL1 ADAMTS3	5.11e-04	19	157	3	IPR010909
Domain	Pribosyltran_N	PRPS2 PRPS1L1	6.91e-04	5	157	2	PF13793
Domain	Pribosyl_synth	PRPS2 PRPS1L1	6.91e-04	5	157	2	PF14572
Domain	Rib-P_diPkinase	PRPS2 PRPS1L1	6.91e-04	5	157	2	IPR005946
Domain	Pribosyltran_N	PRPS2 PRPS1L1	6.91e-04	5	157	2	IPR029099
Domain	EGF_3	SELP ZAN ADAM9 ADAM28 SVEP1 EGF ADGRE1 MASP2	8.54e-04	235	157	8	PS50026
Domain	DIX	DVL1P1 DVL1	1.43e-03	7	157	2	PF00778
Domain	DIX	DVL1P1 DVL1	1.43e-03	7	157	2	IPR001158
Domain	DIX	DVL1P1 DVL1	1.43e-03	7	157	2	PS50841
Domain	DAX	DVL1P1 DVL1	1.43e-03	7	157	2	SM00021
Domain	HEMATOPO_REC_L_F2	OSMR IL27RA	1.90e-03	8	157	2	PS01353
Domain	TSP_1	THSD4 ADAMTSL1 THSD7A ADAMTS3	1.95e-03	63	157	4	PF00090
Domain	ARM-like	IPO5 STK36 SETX ARMC3 RTTN ARMC9 TRRAP WDFY4	2.06e-03	270	157	8	IPR011989
Domain	TSP1	THSD4 ADAMTSL1 THSD7A ADAMTS3	2.18e-03	65	157	4	SM00209
Domain	TSP1_rpt	THSD4 ADAMTSL1 THSD7A ADAMTS3	2.18e-03	65	157	4	IPR000884
Domain	TSP1	THSD4 ADAMTSL1 THSD7A ADAMTS3	2.18e-03	65	157	4	PS50092
Domain	fn3	IGFN1 OBSCN ITGB4 CNTN5 OSMR IL27RA	2.50e-03	162	157	6	PF00041
Domain	WD40_repeat_CS	RAE1 CDC20B WSB2 WDFY4 WDR59 EIF3I	2.66e-03	164	157	6	IPR019775
Domain	-	IPO5 STK36 ARMC3 RTTN ARMC9 TRRAP WDFY4	2.76e-03	222	157	7	1.25.10.10
Domain	TFIIS/CRSP70_N_sub	TCEA3 ELOA2	3.02e-03	10	157	2	IPR003617
Domain	TFS2N	TCEA3 ELOA2	3.02e-03	10	157	2	SM00509
Domain	GFP-like	SVEP1 EGF	3.67e-03	11	157	2	IPR023413
Domain	Pribosyltran	PRPS2 PRPS1L1	3.67e-03	11	157	2	PF00156
Domain	-	SVEP1 EGF	3.67e-03	11	157	2	2.40.155.10
Domain	VWC	ZAN TECTA FCGBP	3.96e-03	38	157	3	SM00214
Domain	EGF	SELP ZAN TECTA SVEP1 EGF	4.25e-03	126	157	5	PF00008
Domain	Pep_M12B_propep	ADAMTS3 ADAM9 ADAM28	4.27e-03	39	157	3	PF01562
Domain	Peptidase_M12B_N	ADAMTS3 ADAM9 ADAM28	4.27e-03	39	157	3	IPR002870
Domain	PRTase-like	PRPS2 PRPS1L1	4.38e-03	12	157	2	IPR029057
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	POMT2 THSD4 ADAMTSL1 THSD7A ADAMTS3 MUC6	1.70e-05	68	113	6	M27303
Pubmed	Identification of two new members of the CSMD gene family.	CSMD2 CSMD3 CSMD1	9.92e-08	3	162	3	12906867
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	IPO5 UBR4 PRPF8 TRRAP ZBP1 GLUD1 GLUD2 PRDX1 C3 SEC23B CAP1	7.15e-07	344	162	11	30333137
Pubmed	Proximity of the CTLA-1 serine esterase and Tcr alpha loci in mouse and man.	GZMB GLUD1 GLUD2	9.85e-07	5	162	3	3182016
Pubmed	Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice.	KLK15 PRSS12 GZMB KLK8	2.55e-06	21	162	4	19592578
Pubmed	Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells.	APEX1 GZMB GZMK	5.46e-06	8	162	3	17008916
Pubmed	Glutamate dehydrogenase in cerebellar mutant mice: gene localization and enzyme activity in different tissues.	GZMB GLUD1 GLUD2	8.16e-06	9	162	3	2293612
Pubmed	Cloning and characterization of human karyopherin beta3.	IPO5 NUP214 NUP153	8.16e-06	9	162	3	9114010
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	DDX19B JCAD TRAF2 GGNBP2 ELOA2 UBR4 CSMD2 PTER ADCY2 KIF7 SUPT7L RAI1 AHNAK2	1.01e-05	638	162	13	31182584
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	IPO5 UBR4 NOL11 NUP214 POGZ PRPF8 TRRAP PES1 EIF3I SEC23B NUP153 CAP1 RAI1	1.29e-05	653	162	13	22586326
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	DDX19B TET2 SETX RAE1 EBF3 ZNF507 APEX1 POGZ GMEB2 TRRAP MED24 PES1 PRDX1 TOP2A NUP153 CAP1 RAI1	1.69e-05	1103	162	17	34189442
Pubmed	Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors.	GLUD1 GLUD2	2.16e-05	2	162	2	34173171
Pubmed	Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.	GLUD1 GLUD2	2.16e-05	2	162	2	28621566
Pubmed	Extent of hematopoietic involvement by TET2 mutations in JAK2V⁶¹⁷F polycythemia vera.	TET2 JAK2	2.16e-05	2	162	2	21273266
Pubmed	GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior.	GLUD1 GLUD2	2.16e-05	2	162	2	32078638
Pubmed	Development of mice with brain-specific deletion of floxed glud1 (glutamate dehydrogenase 1) using cre recombinase driven by the nestin promoter.	GLUD1 GLUD2	2.16e-05	2	162	2	23595828
Pubmed	Interaction between glutamate dehydrogenase (GDH) and L-leucine catabolic enzymes: intersecting metabolic pathways.	GLUD1 GLUD2	2.16e-05	2	162	2	21621574
Pubmed	Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.	GLUD1 GLUD2	2.16e-05	2	162	2	28911206
Pubmed	Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase.	GLUD1 GLUD2	2.16e-05	2	162	2	22875990
Pubmed	The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner.	DDX19B NUP214	2.16e-05	2	162	2	19219046
Pubmed	Molecular basis of human glutamate dehydrogenase regulation under changing energy demands.	GLUD1 GLUD2	2.16e-05	2	162	2	15578726
Pubmed	The classical pathway triggers pathogenic complement activation in membranous nephropathy.	THSD7A C3	2.16e-05	2	162	2	36709213
Pubmed	Important role of Ser443 in different thermal stability of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	2.16e-05	2	162	2	15044002
Pubmed	Association of genetic variations of genes encoding thrombospondin, type 1, domain-containing 4 and 7A with low bone mineral density in Japanese women with osteoporosis.	THSD4 THSD7A	2.16e-05	2	162	2	18488137
Pubmed	Induction of excitatory and inhibitory presynaptic differentiation by GluD1.	GLUD1 GLUD2	2.16e-05	2	162	2	22138648
Pubmed	Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia.	GLUD1 GLUD2	2.16e-05	2	162	2	34220417
Pubmed	Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p.	DDX19B NUP214	2.16e-05	2	162	2	10428971
Pubmed	Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues.	GLUD1 GLUD2	2.16e-05	2	162	2	26241911
Pubmed	Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms.	TET2 JAK2	2.16e-05	2	162	2	20061559
Pubmed	Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum.	GLUD1 GLUD2	2.16e-05	2	162	2	21446915
Pubmed	Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal.	TET2 JAK2	2.16e-05	2	162	2	29991556
Pubmed	GluD1 binds GABA and controls inhibitory plasticity.	GLUD1 GLUD2	2.16e-05	2	162	2	38060673
Pubmed	Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms.	TET2 JAK2	2.16e-05	2	162	2	25281607
Pubmed	Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice.	GLUD1 GLUD2	2.16e-05	2	162	2	24593767
Pubmed	Loss of CSMD1 or 2 may contribute to the poor prognosis of colorectal cancer patients.	CSMD2 CSMD1	2.16e-05	2	162	2	24408017
Pubmed	Potentiation of neuronal activity by tonic GluD1 current in brain slices.	GLUD1 GLUD2	2.16e-05	2	162	2	37154294
Pubmed	PKCζ phosphorylates TRAF2 to protect against intestinal ischemia-reperfusion-induced injury.	TRAF2 PRKCZ	2.16e-05	2	162	2	28726782
Pubmed	Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.	GLUD1 GLUD2	2.16e-05	2	162	2	22924626
Pubmed	Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function.	GLUD1 GLUD2	2.16e-05	2	162	2	11032875
Pubmed	Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.	DVL1P1 DVL1	2.16e-05	2	162	2	8644734
Pubmed	[Relationship between TET2 Gene SNP rs3733609 C/T and JAK2V617F Allele Burden in Patients with Myeloproliferative Neoplasms].	TET2 JAK2	2.16e-05	2	162	2	31607314
Pubmed	Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes.	GLUD1 GLUD2	2.16e-05	2	162	2	29943084
Pubmed	Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory.	GLUD1 GLUD2	2.16e-05	2	162	2	31898404
Pubmed	Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.	GLUD1 GLUD2	2.16e-05	2	162	2	15378063
Pubmed	Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.	GLUD1 GLUD2	2.16e-05	2	162	2	27422263
Pubmed	Critical role of the cysteine 323 residue in the catalytic activity of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	2.16e-05	2	162	2	15750346
Pubmed	Molecular cloning, structure and expression analysis of a full-length mouse brain glutamate dehydrogenase cDNA.	GLUD1 GLUD2	2.16e-05	2	162	2	1711373
Pubmed	Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate.	GLUD1 GLUD2	2.16e-05	2	162	2	20529287
Pubmed	Determination of glutamate dehydrogenase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry).	GLUD1 GLUD2	2.16e-05	2	162	2	25124006
Pubmed	EGF-induced MAPK signaling inhibits hemidesmosome formation through phosphorylation of the integrin {beta}4.	ITGB4 EGF	2.16e-05	2	162	2	20870721
Pubmed	Vascular endothelial cell expression of JAK2V617F is sufficient to promote a pro-thrombotic state due to increased P-selectin expression.	SELP JAK2	2.16e-05	2	162	2	30171023
Pubmed	Unexpected histone H3 tail-clipping activity of glutamate dehydrogenase.	GLUD1 GLUD2	2.16e-05	2	162	2	23673664
Pubmed	Mutations of JAK2 and TET2, but not CBL are detectable in a high portion of patients with refractory anemia with ring sideroblasts and thrombocytosis.	TET2 JAK2	2.16e-05	2	162	2	19903679
Pubmed	Lack of evidence for direct ligand-gated ion channel activity of GluD receptors.	GLUD1 GLUD2	2.16e-05	2	162	2	39052831
Pubmed	Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice.	GLUD1 GLUD2	2.16e-05	2	162	2	24442550
Pubmed	The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity.	GLUD1 GLUD2	2.16e-05	2	162	2	27137930
Pubmed	GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.	GLUD1 GLUD2	2.16e-05	2	162	2	26440896
Pubmed	Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme.	GLUD1 GLUD2	2.16e-05	2	162	2	12742085
Pubmed	Significance of JAK2 and TET2 mutations in myelodysplastic syndromes.	TET2 JAK2	2.16e-05	2	162	2	20171768
Pubmed	Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19.	DDX19B NUP214	2.16e-05	2	162	2	19208808
Pubmed	A genetic association study of CSMD1 and CSMD2 with cognitive function.	CSMD2 CSMD1	2.16e-05	2	162	2	27890662
Pubmed	Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection.	GLUD1 GLUD2	2.16e-05	2	162	2	18688271
Pubmed	The role of the JAK2 GGCC haplotype and the TET2 gene in familial myeloproliferative neoplasms.	TET2 JAK2	2.16e-05	2	162	2	21173100
Pubmed	The complex regulation of human glud1 and glud2 glutamate dehydrogenases and its implications in nerve tissue biology.	GLUD1 GLUD2	2.16e-05	2	162	2	22658952
Pubmed	Mutation in TET2 in myeloid cancers.	TET2 JAK2	2.16e-05	2	162	2	19474426
Pubmed	The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia.	CSMD2 CSMD1	2.16e-05	2	162	2	21439553
Pubmed	TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives.	TET2 CSMD1	2.16e-05	2	162	2	25695618
Pubmed	Increases in anterograde axoplasmic transport in neurons of the hyper-glutamatergic, glutamate dehydrogenase 1 (Glud1) transgenic mouse: Effects of glutamate receptors on transport.	GLUD1 GLUD2	2.16e-05	2	162	2	38124277
Pubmed	Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.	GLUD1 GLUD2	2.16e-05	2	162	2	19015267
Pubmed	Investigation of the inhibitory effects of chelerythrine chloride on the translocation of the protein kinase C betaI, betaII, zeta in human neutrophils.	PRKCB PRKCZ	2.16e-05	2	162	2	11765038
Pubmed	Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum.	GLUD1 GLUD2	2.16e-05	2	162	2	19448744
Pubmed	Chromosomal abnormalities in transformed Ph-negative myeloproliferative neoplasms are associated to the transformation subtype and independent of JAK2 and the TET2 mutations.	TET2 JAK2	2.16e-05	2	162	2	20629097
Pubmed	Single amino acid substitution (G456A) in the vicinity of the GTP binding domain of human housekeeping glutamate dehydrogenase markedly attenuates GTP inhibition and abolishes the cooperative behavior of the enzyme.	GLUD1 GLUD2	2.16e-05	2	162	2	11950837
Pubmed	Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor.	JAK2 IL27RA	2.16e-05	2	162	2	18003935
Pubmed	Effect of mutation order on myeloproliferative neoplasms.	TET2 JAK2	2.16e-05	2	162	2	25671252
Pubmed	Rare mutations in the complement regulatory gene CSMD1 are associated with male and female infertility.	C3 CSMD1	2.16e-05	2	162	2	31604923
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	IPO5 NOL11 APEX1 FAM98A NUP214 CDC37 PRDX1 EIF3I SEC23B NUP153 CAP1	2.22e-05	494	162	11	26831064
Pubmed	EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland.	EGF PRKCB PRKCZ	2.74e-05	13	162	3	12761849
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TET2 HAUS6 UBR4 DVL1 ZNF507 NUP214 POGZ ZNF8 ZFHX3 ZMYM5	2.89e-05	418	162	10	34709266
Pubmed	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.	PRPS2 IPO5 RAE1 UBR4 PRPF8 ARHGEF1 GLUD1 PRDX1 PRKCB EIF3I TOP2A SEC23B CAP1	2.95e-05	707	162	13	19738201
Pubmed	TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture.	APEX1 NUP214 NUP153	3.48e-05	14	162	3	11073998
Pubmed	Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure.	IPO5 RAE1 NUP214 NUP153	3.64e-05	40	162	4	37516964
Pubmed	Interaction network of human early embryonic transcription factors.	TET2 RAE1 NUP214 POGZ ZNF746 GLUD1 ZFHX3 TOP2A RAI1	4.28e-05	351	162	9	38297188
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	PRPS2 RAE1 UBR4 NOL11 FAM98A NUP214 GMEB2 PRPF8 CDC37 ARHGEF1 PES1 GLUD1 PRDX1 PRKCB EIF3I TOP2A SEC23B NUP153	4.62e-05	1318	162	18	30463901
Pubmed	Polymorphisms in innate immunity genes and risk of childhood leukemia.	KLK15 SELP C1RL C3 MUC6 MASP2 SECTM1	5.42e-05	206	162	7	20438785
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DDX19B TET2 JCAD STIM2 SETX FAM98A PTER WDR59 ARHGEF1 NAV2 OSBPL10 EIF3I SEC23B AHNAK2	5.50e-05	861	162	14	36931259
Pubmed	Risk of meningioma and common variation in genes related to innate immunity.	KLK15 SELP C1RL C3 MUC6 MASP2 SECTM1	5.59e-05	207	162	7	20406964
Pubmed	Common variation in genes related to innate immunity and risk of adult glioma.	KLK15 SELP C1RL C3 MUC6 MASP2 SECTM1	5.76e-05	208	162	7	19423540
Pubmed	Myosin-X recruits lamellipodin to filopodia tips.	PRPS2 TRAF2 RAE1 UBR4 OSBPL10	6.24e-05	89	162	5	36861887
Pubmed	The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.	RAE1 NUP214 NUP153	6.43e-05	17	162	3	10668806
Pubmed	The structure of apo human glutamate dehydrogenase details subunit communication and allostery.	GLUD1 GLUD2	6.45e-05	3	162	2	12054821
Pubmed	Supplemental Association of Clonal Hematopoiesis With Incident Heart Failure.	TET2 JAK2	6.45e-05	3	162	2	34210413
Pubmed	Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population.	OSBPL10 CSMD1	6.45e-05	3	162	2	20610895
Pubmed	Promoter regions of the human X-linked housekeeping genes PRPS1 and PRPS2 encoding phosphoribosylpyrophosphate synthetase subunit I and II isoforms.	PRPS2 PRPS1L1	6.45e-05	3	162	2	1314091
Pubmed	Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons.	GLUD1 GLUD2	6.45e-05	3	162	2	31704028
Pubmed	Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells.	SELP ADAM28	6.45e-05	3	162	2	17597069
Pubmed	The characterization of the Olf-1/EBF-like HLH transcription factor family: implications in olfactory gene regulation and neuronal development.	EBF3 EBF2	6.45e-05	3	162	2	9151732
Pubmed	Foreign body-type multinucleated giant cell formation requires protein kinase C beta, delta, and zeta.	PRKCB PRKCZ	6.45e-05	3	162	2	18067888
Pubmed	Apurinic/apyrimidinic endonuclease 1 inhibits protein kinase C-mediated p66shc phosphorylation and vasoconstriction.	APEX1 PRKCB	6.45e-05	3	162	2	21467074
Pubmed	Overexpression of the oncostatin-M receptor in cervical squamous cell carcinoma is associated with epithelial-mesenchymal transition and poor overall survival.	JAK2 OSMR	6.45e-05	3	162	2	27351213
Pubmed	Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev.	NUP214 NUP153	6.45e-05	3	162	2	9847314
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	SELP C1RL APOH CSMD2 CSMD3 SVEP1 CSMD1 MASP2	8.71e-10	57	100	8	1179
GeneFamily	WD repeat domain containing	CFAP251 RAE1 ARPC1A CDC20B WSB2 WDFY4 WDR59 WDR73 ELP2 EIF3I	1.89e-06	262	100	10	362
GeneFamily	Nucleoporins	DDX19B RAE1 NUP214 NUP153	2.81e-05	32	100	4	1051
GeneFamily	Fibronectin type III domain containing	IGFN1 OBSCN ITGB4 CNTN5 OSMR IL27RA	2.63e-04	160	100	6	555
GeneFamily	ADAMTS like	THSD4 ADAMTSL1	6.25e-04	7	100	2	947
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	ADAMTSL1 IGFN1 OBSCN IGSF10 CNTN5	2.01e-03	161	100	5	593
GeneFamily	Kallikreins	KLK15 KLK8	3.46e-03	16	100	2	616
GeneFamily	Lysine acetyltransferases\|ATAC complex\|SAGA complex\|GCN5 related N-acetyltransferases	TRRAP SUPT7L	3.90e-03	17	100	2	1059
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 ADAMTSL1 C1RL GAREM2 C3 TACR2 MUC6 AHNAK2	1.85e-07	167	162	8	7abc785e688a384672d7fb5a62d32538fe7e5a51
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	THSD4 ADAMTSL1 C1RL GAREM2 C3 TACR2 MUC6 AHNAK2	1.85e-07	167	162	8	d50311b1f66f143bae4c4cf50e2e9b13c85d6920
ToppCell	Tracheal\|World / Cell types per location group and 10X technology with lineage, and cell group designations	GARNL3 ITGB4 ADCY2 ADAM28 FCGBP EGF AACS OSBPL10	7.29e-07	200	162	8	682960e28542a3d6c119047cd0131941932cfdea
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	ADAMTSL1 CSMD2 CSMD3 GRM7 ADCY2 CNTN5 CSMD1	1.94e-06	159	162	7	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	COVID-19-Heart-CM_+_Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	THSD4 OBSCN WDFY4 NRP2 FCGBP CD163L1 PRKCB	3.03e-06	170	162	7	4232fe937909f93d3736988c707b8f95ce993398
ToppCell	droplet-Kidney-nan-21m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZDHHC2 JCAD THSD7A EBF3 ITGB4 ADCY2 OSMR	4.25e-06	179	162	7	b7281160c84dd053a2981c9c76ea6cc6d2592cd5
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0408 STK36 IGFN1 ZAN OBSCN CSMD3 CSMD1	5.10e-06	184	162	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0408 STK36 IGFN1 ZAN OBSCN CSMD3 CSMD1	5.10e-06	184	162	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0408 STK36 IGFN1 ZAN OBSCN CSMD3 CSMD1	5.10e-06	184	162	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 ARMC9 PTER LRG1 ZNF8 CD163L1 PRKCZ	5.28e-06	185	162	7	bb5a4cf93534b9bcd0923f314c389d571e91e7f8
ToppCell	COVID-19_Mild-Neu_3\|World / 5 Neutrophil clusters in COVID-19 patients	OBSCN LRTM1 ARMC9 CSMD3 GLUD2 CSMD1	5.69e-06	122	162	6	2aa9cfadab70312882ae679e3788fc7ab996c0f3
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D175\|Adult / Lineage, Cell type, age group and donor	ADAMTSL1 ADAMTS3 EBF3 SVEP1 KIF7 EBF2 C3	6.29e-06	190	162	7	7dcca3469f3a3b70db0420cb94f7765f39492f06
ToppCell	facs-Lung-3m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZDHHC2 ADAMTSL1 THSD7A LRG1 NRP2 BOK PRKCZ	6.29e-06	190	162	7	26e2237f65cb43723c5da853831b40df2982d6e4
ToppCell	facs-Lung-3m-Endothelial-lymphatic_endothelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZDHHC2 ADAMTSL1 THSD7A LRG1 NRP2 BOK PRKCZ	6.29e-06	190	162	7	a1514d2186eb4fe569971ab22dc0c17d353fb94a
ToppCell	facs-Lung-3m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZDHHC2 ADAMTSL1 THSD7A LRG1 NRP2 BOK PRKCZ	6.29e-06	190	162	7	0bb954a94317cfc742b9b6221bb80f8baa6d3ff1
ToppCell	facs-Lung-nan-3m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZDHHC2 ADAMTSL1 THSD7A EBF3 NRP2 BOK PRKCZ	6.51e-06	191	162	7	48823a97c38263f2c6e58348214f5b62773a6368
ToppCell	facs-Lung-nan-3m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZDHHC2 ADAMTSL1 THSD7A EBF3 NRP2 BOK PRKCZ	6.51e-06	191	162	7	0eedc66e967b1837ce2c14f8c14b3c1eba868c76
ToppCell	RV-08._Macrophage\|World / Chamber and Cluster_Paper	WDFY4 ADAM28 NRP2 CD163L1 PRKCB MUC6 TOP2A	6.74e-06	192	162	7	a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ZAN ERV3-1 RBP3 CDC20B CSMD3 NPHS2 MUC6	6.97e-06	193	162	7	315840bc48899f3a36d57b19197509de19716e3d
ToppCell	RV-08._Macrophage\|RV / Chamber and Cluster_Paper	WDFY4 ADAM28 NRP2 CD163L1 PRKCB MUC6 TOP2A	6.97e-06	193	162	7	12bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Pvrl3\|Hippocampus / BrainAtlas - Mouse McCarroll V32	THSD4 STIM2 RBP3 FCGBP BOK KLK8	7.17e-06	127	162	6	9bc55cb9f4bddb274930784d12a83b9dceb35cb7
ToppCell	5'-GW_trimst-2-LymphNode-Mesenchymal-fibroblastic-mLTo\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRPS2 EBF3 TAFA3 JAK2 NAV2 C3 OSMR	7.21e-06	194	162	7	c45e9d09b5cd6973de6c3f1713b3bf36fa4bfe57
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)--\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SELP ZAN LRG1 SPACA1 IL27RA	1.32e-05	83	162	5	3aa95bf2d8ac37e648037faf3d54ebb243a4fde1
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SELP ZAN LRG1 SPACA1 IL27RA	1.32e-05	83	162	5	70804dd63221dd5ed26068ec1b50f11875abbc50
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lrg1_(Lrg1)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SELP ZAN LRG1 SPACA1 IL27RA	1.32e-05	83	162	5	c1818411438f53aec76afead5c8caab701b95d39
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_2\|Cerebellum / BrainAtlas - Mouse McCarroll V32	SELP ZAN LRG1 SPACA1 IL27RA	1.32e-05	83	162	5	1e7af8aaa20b4c2a77cf2f330113db0faa9d483c
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	THNSL1 ADCY2 SVEP1 GZMB PRKCB CA4	2.15e-05	154	162	6	ea5d0da5dd8ccfc19969aec35f044db77d589f54
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_ALM_Cpa6\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	JCAD STIM2 GARNL3 PRSS12 OBSCN ZFHX3	2.15e-05	154	162	6	12cbc38bc1f7231c67e1d2d5e86e95bc12e24682
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	JCAD GARNL3 OBSCN TMEM196 PRKCB ZFHX3	2.86e-05	162	162	6	58da6bc04cdac0002b0e6a751c96ff95e1a7f70f
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Brinp3\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	JCAD GARNL3 OBSCN TMEM196 PRKCB ZFHX3	2.96e-05	163	162	6	b0aa4a620bd58011225b42ea6dda04e3101ba342
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	RTTN LRTM1 ERCC6L2 ELP2 PLEKHA8 CARD14	3.28e-05	166	162	6	f62db9d9b6c9dd8f2afcaea0fc5f8c69f50205b2
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCEA3 APOH PTER GPR179 BOK MASP2	3.50e-05	168	162	6	b14fd50232887b6dca1f39014d43c6f66e5c3b5c
ToppCell	droplet-Marrow-BM-30m-Hematologic-hematopoietic_precursor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS12 GZMB GZMK KLK8 PRKCZ IL27RA	3.74e-05	170	162	6	f8defd260dadd202692282e834ed7f38193eb553
ToppCell	COVID-19-Heart-T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	IGFN1 CSMD3 GRM7 ADCY2 CNTN5 CSMD1	3.87e-05	171	162	6	b2e753e811a7639956994609f73efcdb62d04f82
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ADAMTSL1 EBF3 TECTA SVEP1 EBF2 C3	4.00e-05	172	162	6	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	WDR59 ZNF8 DDIAS OSBPL10 TARBP2 TOP2A	4.00e-05	172	162	6	2b6cd84c946b1e800caba452ae70145ea285fec1
ToppCell	Endothelial-Endothelial-G\|Endothelial / shred on cell class and cell subclass (v4)	THSD4 ADAMTSL1 LRG1 NRP2 BOK PRKCZ	4.00e-05	172	162	6	644f8e42ee8d8996f6ae50cdf874559be55509fc
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD4 JCAD ADAMTSL1 PRSS12 GRM7 CNTN5	4.26e-05	174	162	6	b3cd22e717d178269e6d5bd5ed7b2d945cd8ea25
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 LRG1 NRP2 ZNF8 ZSCAN2 PRKCZ	4.40e-05	175	162	6	09163e7030f76d706eccabdb1d5ec45f8412aa75
ToppCell	P15-Endothelial-lymphatic_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADAMTSL1 EBF3 LRG1 NRP2 BOK PRKCZ	4.40e-05	175	162	6	a00c6fa9b33640710dd05a3799031147196f0986
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THSD4 LRTM1 GRM7 WDFY4 ITGB4 ADAM28	4.40e-05	175	162	6	9a96794df049d8228fea57c1584c160191d36b56
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 LRG1 NRP2 ZNF8 ZSCAN2 PRKCZ	4.40e-05	175	162	6	0801cccec6915aefc135262fc74580280fd51aa5
ToppCell	P15-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ADAMTSL1 EBF3 LRG1 NRP2 BOK PRKCZ	4.40e-05	175	162	6	84d252f3e432231687613299bbea14978bb4b06b
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTSL1 EBF3 GRM7 ADCY2 EBF2 C3	4.69e-05	177	162	6	9ec7f1e64312d26d434b3312b58386715dbad644
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTSL1 EBF3 GRM7 ADCY2 EBF2 C3	4.69e-05	177	162	6	016277dfd59b1793fddaaadc2b3f41622d76ce3a
ToppCell	COVID-19-kidney-Epi_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	ARMC3 ADAMTS3 GRM7 NRP2 OSBPL10 C3	4.99e-05	179	162	6	e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCell	3'-Adult-Appendix-Hematopoietic-Plasma_cells-IgA_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTSL1 RTTN WDFY4 ADAM28 ZNF746 TOP2A	4.99e-05	179	162	6	2285e3a9018a60d7f6e974fee46b6f61d39aa76f
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Mucinous_Colon_Adenocarcinoma-10\|TCGA-Colorectal / Sample_Type by Project: Shred V9	THSD7A ADAMTS3 EBF3 CSMD2 SVEP1 OSMR	4.99e-05	179	162	6	cc079ba015326dccde955c5eafa3e4a2e40de192
ToppCell	3'-Adult-Appendix-Hematopoietic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTSL1 RTTN WDFY4 ADAM28 ZNF746 TOP2A	4.99e-05	179	162	6	0b0f27d7c5cc5ae7618d887dcfa7219df8ff1935
ToppCell	3'-Adult-Appendix-Hematopoietic-Plasma_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTSL1 RTTN WDFY4 ADAM28 ZNF746 TOP2A	4.99e-05	179	162	6	63bc819df62b1f8f37bf1f17bdd4fcc161886923
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IGFN1 EBF3 ADCY2 SVEP1 NRP2 EBF2	5.15e-05	180	162	6	c2746092ef251e9d5910fe96461afdd0624a24c6
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	IGFN1 EBF3 ADCY2 SVEP1 NRP2 EBF2	5.15e-05	180	162	6	32c6a3886428d82fb4355d987c6d2645f333447b
ToppCell	droplet-Liver-nan-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HAUS6 SETX DPY19L1 TAFA3 NRP2 JAK2	5.31e-05	181	162	6	fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCell	facs-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTSL1 THSD7A LRTM1 NRP2 BOK ZSCAN2	5.31e-05	181	162	6	cc77ac0e223e012767222e45c5dcadc246d1aa7c
ToppCell	facs-Lung-18m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTSL1 THSD7A LRTM1 NRP2 BOK ZSCAN2	5.31e-05	181	162	6	b0fff0defba9aea6fba36e378b05a59986e2573a
ToppCell	facs-Lung-18m-Endothelial-lymphatic_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTSL1 THSD7A LRTM1 NRP2 BOK ZSCAN2	5.31e-05	181	162	6	ecd52f33841f4e9d946a4edad0d58da9b0cc5ffa
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZDHHC2 CCDC159 DDIAS SPACA1 PRKCZ TOP2A	5.47e-05	182	162	6	3948422707d6d5e021bcd7158e2eb69143613f62
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic-Proliferating_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZDHHC2 CCDC159 DDIAS SPACA1 PRKCZ TOP2A	5.47e-05	182	162	6	fe46819c153a81911864473badc794f243705f98
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTS3 C1RL CSMD2 SVEP1 KIF7 C3	5.99e-05	185	162	6	9faa35ceb89ccd2979072286f063687c9f846ce3
ToppCell	COVID-19-kidney-Fibroblast-1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	THSD4 CFAP251 ADAMTSL1 SVEP1 NAV2 OSMR	6.36e-05	187	162	6	76bfe8c42430a230a8bdf299575c444fb7780f24
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	WDFY4 DDIAS FCGBP GZMK PRKCB TOP2A	6.36e-05	187	162	6	73931a5ea73799095daff100b5f18853c57c74dc
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	THSD7A PRSS12 CSMD3 SVEP1 IGSF10 PRKCB	6.74e-05	189	162	6	203c80030df08ae112f9ae4043709f455d87ce89
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P5-P5_2-Sox4-POLYDENDROCYTE_(Rostral-�migratory_stream-�(RMS)_(Ung))\|Striatum / BrainAtlas - Mouse McCarroll V32	EBF3 APOH KIF7 EBF2	6.75e-05	60	162	4	eb1095bce18184254db2691f31e5d3f40da279a1
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SVEP1 KIF7 NAV2 NUP153	6.94e-05	190	162	6	048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	THSD4 ADAMTSL1 SVEP1 KIF7 NAV2 NUP153	6.94e-05	190	162	6	1121eb607a984c59fbffe7220837fc178745aa55
ToppCell	droplet-Kidney-nan-3m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0408 ADAMTSL1 EBF3 ADCY2 SVEP1 IGSF10	6.94e-05	190	162	6	f61e21d53f2f7804ac6e40ab6c7f69838aa94d6a
ToppCell	P15-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ZDHHC2 SELP ITGB4 LRG1 NRP2 KLK8	6.94e-05	190	162	6	d072bb285bd34d518b958e7c9ad44739c60b359c
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	THSD4 JCAD THSD7A CSMD2 GRM7 CNTN5	6.94e-05	190	162	6	1bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCell	droplet-Kidney-nan-3m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0408 ADAMTSL1 EBF3 ADCY2 SVEP1 IGSF10	7.15e-05	191	162	6	d1205aab0937f2becfcd239610e9b78fb8a0c886
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IGFN1 ADAMTS3 EBF3 SVEP1 TMEM196 EBF2	7.15e-05	191	162	6	2c51850f5c559d665b8a27a12b75af9ed58dffe1
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SVEP1 EBF2 IGSF10 C3 OSMR CSMD1	7.35e-05	192	162	6	853a930e0641ffb50cbb4cef5837c70d75c3fc39
ToppCell	LV-08._Macrophage\|LV / Chamber and Cluster_Paper	WDFY4 ADAM28 NRP2 CD163L1 PRKCB MUC6	7.35e-05	192	162	6	7be12d580aaf2f2f1562203fcad3a44639b8c5a6
ToppCell	droplet-Kidney-nan-18m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 SVEP1 EBF2 IGSF10 OSMR CSMD1	7.35e-05	192	162	6	84149a5c6c3b3c9b86aed77cf8e72d99ef099fab
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SVEP1 EBF2 IGSF10 C3 OSMR CSMD1	7.35e-05	192	162	6	49281626ecad0456fdbded2378b7028d7b589686
ToppCell	droplet-Pancreas-Endocrine-21m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JCAD ADAMTSL1 ADAMTS3 EBF3 PRSS12 SVEP1	7.57e-05	193	162	6	59b8186d0221fba06a16157e9d148399ed801f38
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IGFN1 ADAMTS3 SVEP1 TMEM196 EBF2 NAV2	7.57e-05	193	162	6	09a9ab029f01234459a88e3e994fe90ef4cbb8c6
ToppCell	droplet-Pancreas-Endocrine-21m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JCAD ADAMTSL1 ADAMTS3 EBF3 PRSS12 SVEP1	7.57e-05	193	162	6	dc92680b4bb9fc26430c92e03adb839c8c3b3b98
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-10\|TCGA-Colorectal / Sample_Type by Project: Shred V9	SELP THSD7A EBF3 EBF2 C3 OSMR	7.57e-05	193	162	6	194e7fa00a50cc4e026987b715323d125d79594e
ToppCell	droplet-Pancreas-Endocrine-21m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JCAD ADAMTSL1 ADAMTS3 EBF3 PRSS12 SVEP1	7.57e-05	193	162	6	03678162648bd5b1d65a5450b60c8863edbf95c7
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ADAMTSL1 CHRNA9 ADAM9 NRP2 NAV2 OSMR	7.79e-05	194	162	6	f44394c8a6f86483063f2f5722f003a8a0a70254
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	IGFN1 ADAMTS3 EBF3 SVEP1 NAV2 C3	7.79e-05	194	162	6	c49f72441b3557e2c3a9c4239e68c0cf0652814b
ToppCell	LA-08._Macrophage\|LA / Chamber and Cluster_Paper	WDFY4 ADAM28 NRP2 CD163L1 PRKCB MUC6	8.01e-05	195	162	6	5e1d5bdb8874091f5a2b1d0a8cc9008165718a97
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-TAM-MG\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ADAM9 ADAM28 NRP2 FCGBP C3 ZFHX3	8.71e-05	198	162	6	9aced8bdb56ee52866a0a9766a84336961bc4443
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid-Macrophages\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	WDFY4 CD163L1 PRKCB ADGRE1 CARD14 SECTM1	8.71e-05	198	162	6	88635244a0b306d2cc50b8412fe47bb359c9cf00
ToppCell	COPD-Myeloid-Macrophage\|Myeloid / Disease state, Lineage and Cell class	TET2 ADAM9 ADAM28 NRP2 CD163L1 CSMD1	8.96e-05	199	162	6	1cf1b2d6debf9e3389f1829dcaa2857e9533a080
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	KIAA0408 ADAMTS3 PRSS12 ADAM9 SVEP1 IGSF10	8.96e-05	199	162	6	30d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CHRNA9 ABHD12B NRP2 NAV2 OSMR AHNAK2	8.96e-05	199	162	6	85bb28369e0568b7b3bda095722102fc793f60ef
ToppCell	COVID-19-kidney-Epithelial_Doublet\|kidney / Disease (COVID-19 only), tissue and cell type	CHRNA9 CSMD3 GRM7 WDFY4 PRKCB	9.07e-05	124	162	5	d6f59ddb9b9df02b5201f23fa5fb78f3fd891ee9
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTSL1 EBF3 SVEP1 EBF2 NAV2 C3	9.21e-05	200	162	6	0c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	KIAA0408 ADAMTS3 PRSS12 ADAM9 SVEP1 IGSF10	9.21e-05	200	162	6	bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCell	COVID-19-B_cells-B_cells\|COVID-19 / group, cell type (main and fine annotations)	WDFY4 ADAM28 DPPA4 OSBPL10 PRKCB	1.13e-04	130	162	5	267b06a0db31e2664cf595cd737402da07ab51cd
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Sla\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	IGFN1 ADAMTS3 APOH LRG1 EBF2	1.22e-04	132	162	5	ddebc0b233fdbb73ceb70187945bbed8fd273f2a
ToppCell	PBMC-Mild-cDC_4\|Mild / Compartment, Disease Groups and Clusters	CFAP251 IGSF10 TACR2 ZNF749 ELP2	1.26e-04	133	162	5	e53fbd69775a4bff61de82557342f7ac80915c4d
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Vwf)--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SELP LRG1 KLK8 MUC6	1.53e-04	74	162	4	13093139a75bfe11f6b032c9fb402efcc703551c
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Vwf)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SELP LRG1 KLK8 MUC6	1.53e-04	74	162	4	7f7de9e8142d2435391ee965cee5628e412f0705
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Lcn2_(Vwf)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SELP LRG1 KLK8 MUC6	1.53e-04	74	162	4	0288a3f4eafbc359d01cde4ba58f946dd07c77cb
ToppCell	Globus_pallidus-Endothelial-ENDOTHELIAL_STALK-Flt1_2\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SELP LRG1 KLK8 MUC6	1.53e-04	74	162	4	57884ade66fe39398351685189df5efd7aea0aab
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_ALM_Macc1_Lrg1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	IGFN1 ADAMTS3 APOH LRG1 EBF2	1.71e-04	142	162	5	d08e1880425d285c4433014fe0242ac7ff7734af
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DPY19L1 ABHD12B GMEB2 OSMR SECTM1	1.83e-04	144	162	5	3d880c140db4a0e7602bfddcb73a42a68c2848d5
ToppCell	COVID-19-kidney-Technical/muscle_(PCT)\|kidney / Disease (COVID-19 only), tissue and cell type	CSMD2 CSMD3 GRM7 CNTN5 CSMD1	1.95e-04	146	162	5	c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
Drug	Methacycline hydrochloride [3963-95-9]; Down 200; 8.4uM; PC3; HT_HG-U133A	THSD4 TRAF2 CHRNA9 PRSS12 ITGB4 NRP2 JAK2 HPS1 ZNF749 OSMR	1.53e-06	198	161	10	4062_DN
Disease	response to methotrexate, aspartate aminotransferase measurement	THSD4 SELP NOL11	5.15e-05	14	157	3	EFO_0004736, GO_0031427
Disease	fascioliasis (biomarker_via_orthology)	GLUD1 GLUD2	8.41e-05	3	157	2	DOID:885 (biomarker_via_orthology)
Disease	lung non-small cell carcinoma (is_implicated_in)	TET2 ADAM28 JAK2 EGF PRKCB ZFHX3	1.03e-04	139	157	6	DOID:3908 (is_implicated_in)
Disease	lung adenocarcinoma (is_implicated_in)	ADAM28 JAK2 EGF ZFHX3	1.36e-04	49	157	4	DOID:3910 (is_implicated_in)
Disease	complement C1r subcomponent-like protein measurement	C1RL APOH	1.68e-04	4	157	2	EFO_0801495
Disease	Myelofibrosis	TET2 JAK2	1.68e-04	4	157	2	C0026987
Disease	neuroticism measurement, cognitive function measurement	TET2 THSD7A ZNF507 GRM7 ADCY2 MED24 NAV2 OSBPL10 ZFHX3 CSMD1 RAI1	2.36e-04	566	157	11	EFO_0007660, EFO_0008354
Disease	Ovarian Serous Adenocarcinoma	STK36 TRRAP JAK2	2.42e-04	23	157	3	C1335177
Disease	mucinous adenocarcinoma (is_marker_for)	ZFHX3 MUC6	2.78e-04	5	157	2	DOID:3030 (is_marker_for)
Disease	DiGeorge syndrome (is_implicated_in)	DVL1P1 DVL1	2.78e-04	5	157	2	DOID:11198 (is_implicated_in)
Disease	childhood absence epilepsy (biomarker_via_orthology)	GLUD1 GLUD2	4.16e-04	6	157	2	DOID:1825 (biomarker_via_orthology)
Disease	Primary Myelofibrosis	TET2 JAK2	4.16e-04	6	157	2	C0001815
Disease	Autistic Disorder	CSMD3 TRRAP WDFY4 NRP2 EGF GZMB PRKCB	5.16e-04	261	157	7	C0004352
Disease	Polycythemia Vera	TET2 JAK2	7.71e-04	8	157	2	C0032463
Disease	coronary aneurysm	CSMD2 NAV2 CSMD1	8.54e-04	35	157	3	EFO_1000881
Disease	Disorder of eye	ADAM9 RBP3 PRPF8 GPR179 KIF7 CA4	9.84e-04	212	157	6	C0015397
Disease	response to topoisomerase inhibitor, response to antineoplastic agent	THSD7A GRM7	9.88e-04	9	157	2	GO_0072758, GO_0097327
Disease	membranous glomerulonephritis (implicated_via_orthology)	NPHS2 C3	9.88e-04	9	157	2	DOID:10976 (implicated_via_orthology)
Disease	liver cancer (is_marker_for)	ADAM28 JAK2	9.88e-04	9	157	2	DOID:3571 (is_marker_for)
Disease	3-methyl-2-oxobutyrate measurement	ANKRD50 PES1	1.23e-03	10	157	2	EFO_0021020
Disease	thrombosis (implicated_via_orthology)	APOH JAK2	1.23e-03	10	157	2	DOID:0060903 (implicated_via_orthology)
Disease	sleep time	ARMC3 EBF3	1.23e-03	10	157	2	EFO_0005274
Disease	periodontitis	THSD4 OSBPL10 WDR73 ZFHX3 CSMD1 ADGRE1	1.28e-03	223	157	6	EFO_0000649
Disease	Thrombocythemia, Essential	TET2 JAK2	1.79e-03	12	157	2	C0040028
Disease	Neurobehavioral Manifestations	SELP RAI1	1.79e-03	12	157	2	C0525041
Disease	heart rate variability measurement, response to antipsychotic drug	NAV2 OSMR CSMD1	1.90e-03	46	157	3	EFO_0008003, GO_0097332
Disease	dimethylglycine measurement	ADAMTSL1 CSMD3 CNTN5	1.90e-03	46	157	3	EFO_0010476
Disease	pancreatic cancer (is_marker_for)	ADAM9 EGF MUC6 CAP1	2.11e-03	101	157	4	DOID:1793 (is_marker_for)
Disease	fructose measurement	UBR4 PTER	2.11e-03	13	157	2	EFO_0010477
Disease	melanoma	UBR4 APEX1 PTER TRRAP CD163L1 RAI1	2.18e-03	248	157	6	C0025202
Disease	brain ischemia (biomarker_via_orthology)	APEX1 GLUD1 GLUD2 C3	2.19e-03	102	157	4	DOID:2316 (biomarker_via_orthology)
Disease	lung carcinoma, estrogen-receptor negative breast cancer, ovarian endometrioid carcinoma, colorectal cancer, prostate carcinoma, ovarian serous carcinoma, breast carcinoma, ovarian carcinoma, lung adenocarcinoma, squamous cell lung carcinoma	TET2 DVL1P1 DVL1	2.70e-03	52	157	3	EFO_0000305, EFO_0000571, EFO_0000708, EFO_0001071, EFO_0001075, EFO_0001663, EFO_1000650, EFO_1001515, EFO_1001516, MONDO_0005575
Disease	severe acute respiratory syndrome, COVID-19	THSD4 THSD7A LRTM1 GRM7 WDFY4 ZFHX3 ELP2 CSMD1	2.80e-03	447	157	8	EFO_0000694, MONDO_0100096
Disease	myelodysplastic syndrome (implicated_via_orthology)	TET2 PRPF8	2.82e-03	15	157	2	DOID:0050908 (implicated_via_orthology)
Disease	hepatic encephalopathy (biomarker_via_orthology)	GLUD1 GLUD2	2.82e-03	15	157	2	DOID:13413 (biomarker_via_orthology)
Disease	leukemia	JAK2 PRKCZ TOP2A	3.17e-03	55	157	3	C0023418
Disease	Drug habituation	THSD4 CSMD3 GRM7 CSMD1	3.37e-03	115	157	4	C0013170
Disease	Drug abuse	THSD4 CSMD3 GRM7 CSMD1	3.37e-03	115	157	4	C0013146
Disease	Prescription Drug Abuse	THSD4 CSMD3 GRM7 CSMD1	3.37e-03	115	157	4	C4316881
Disease	Substance-Related Disorders	THSD4 CSMD3 GRM7 CSMD1	3.37e-03	115	157	4	C0236969
Disease	Drug Use Disorders	THSD4 CSMD3 GRM7 CSMD1	3.37e-03	115	157	4	C0013222
Disease	Drug Dependence	THSD4 CSMD3 GRM7 CSMD1	3.37e-03	115	157	4	C1510472
Disease	Substance Dependence	THSD4 CSMD3 GRM7 CSMD1	3.37e-03	115	157	4	C0038580
Disease	Substance Use Disorders	THSD4 CSMD3 GRM7 CSMD1	3.37e-03	115	157	4	C0038586
Disease	Organic Mental Disorders, Substance-Induced	THSD4 CSMD3 GRM7 CSMD1	3.37e-03	115	157	4	C0029231
Disease	forced expiratory volume	THSD4 TET2 JCAD ADAMTSL1 THSD7A TRIM71 SVEP1 ANAPC10 BOK ARHGEF1 ERCC6L2	3.43e-03	789	157	11	EFO_0004314
Disease	Substance abuse problem	THSD4 CSMD3 GRM7 CSMD1	3.48e-03	116	157	4	C0740858
Disease	amino acid measurement	IPO5 SETX GRM7 ADAM28 NRP2 CNTN5 RP1L1 GLUD1 CSMD1 IL27RA	3.51e-03	678	157	10	EFO_0005134
Disease	uridine diphosphate galactose measurement, uridine diphosphate glucose measurement	JCAD IGFN1	3.63e-03	17	157	2	EFO_0010543, EFO_0010544
Disease	hyperglycemia (implicated_via_orthology)	PRKCB PRKCZ	3.63e-03	17	157	2	DOID:4195 (implicated_via_orthology)
Disease	respiratory symptom change measurement, response to placebo	EBF2 NAV2	3.63e-03	17	157	2	EFO_0008344, EFO_0010068
Disease	lupus nephritis (is_marker_for)	EGF C3	3.63e-03	17	157	2	DOID:0080162 (is_marker_for)
Disease	Acute myeloid leukemia	NUP214 JAK2	3.63e-03	17	157	2	cv:C0023467
Disease	LEUKEMIA, ACUTE MYELOID	NUP214 JAK2	3.63e-03	17	157	2	601626
Disease	chronic obstructive pulmonary disease	THSD4 TET2 JCAD ADAMTSL1 CDC20B NRP2 MED24 CNTN5 PRDX1 ERCC6L2	3.89e-03	688	157	10	EFO_0000341
Disease	anorectal malformation	ZNF507 CSMD2	4.53e-03	19	157	2	MONDO_0019938
Disease	atherosclerosis (biomarker_via_orthology)	SELP JAK2	5.02e-03	20	157	2	DOID:1936 (biomarker_via_orthology)
Disease	breast carcinoma (is_marker_for)	APEX1 ADAM28 ZFHX3	5.29e-03	66	157	3	DOID:3459 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
AKWSGACVLGTIRPS	ERV3-1	431	Q14264
WCALITETAGSLKVP	ARHGEF1	751	Q92888
ASAWGVTLSPKDCQV	LRG1	31	P02750
DGPEEIECTKLGNWS	APOH	241	P02749
SITCVIGADGKPSWD	CSMD1	1601	Q96PZ7
NGKWSLGDSTPTCRI	CSMD2	2641	Q7Z408
DNTWTGKVPICEAGS	CSMD3	3456	Q7Z407
WGKVEVRPSCSGAAA	CXorf49;	291	A8MYA2
CTELWGPGTEVADKS	ADAM28	516	Q9UKQ2
KAVWGESGELVCTKP	AACS	476	Q86V21
TGVKTKPSCGGWRAV	BRICD5	16	Q6PL45
TCSVAGWGQTAPLGK	GZMB	141	P10144
GTKCKVTGWGATDPD	GZMK	146	P49863
IWHTVPSCRGEDAKG	ABHD12B	111	Q7Z5M8
TCSVAPLWEKSKGSG	C8orf89	101	P0DMQ9
AWSKTGPVAKELSGL	CAP1	206	Q01518
IWDVVEKADIGCTPG	C3	616	P01024
ATPCIKAISPSEGWT	EBF2	251	Q9HAK2
CVVHGKSLPADTDGW	DPPA4	231	Q7L190
GLITWDAPAITKSSC	CHRNA9	141	Q9UGM1
SGKTALCTELLWPSS	ANKRD50	81	Q9ULJ7
VGEGSSDKEWCPPSD	ARMC3	706	Q5W041
SGKPATLKICSWNVD	APEX1	56	P27695
GPIWLDDVSCIGNES	CD163L1	536	Q9NR16
WTDVLKCVVSTDPGL	BOK	171	Q9UMX3
TGIDWAPKSDRIVTC	ARPC1A	56	Q92747
TADKGPDCLVIIWDS	CFAP251	316	Q8TBY9
GWKSEPATCSVKGSE	CFAP251	1101	Q8TBY9
LDSGSPLRWECKATG	CNTN5	401	O94779
IETCEDPGDWTAAIG	GMEB2	216	Q9UKD1
TGPVLDVCWSDDGSK	RAE1	86	P78406
EVLDSKAGWGSPCHL	RAI1	906	Q7Z5J4
KTLHCTWDPGTDTAL	OSMR	251	Q99650
TTLWEICSGGDKPLS	JAK2	741	O60674
LGSPLAASKECLSVW	NOL11	276	Q9H8H0
WKESPLCGDVSFVTD	MUC6	1031	Q6W4X9
GDWHSPTLIREKSCG	ELOA2	241	Q8IYF1
GNELSIEQCPKSSWG	PRSS12	351	P56730
GPIWLDDVSCSGKET	PRSS12	446	P56730
DGIICESPDTWKGKD	LRTM1	206	Q9HBL6
DSDGKLCRPWGVSVD	TRIM71	601	Q2Q1W2
INTESSLWSLEPGKC	NUDCD3	246	Q8IVD9
DHKRPICSGWLTTAG	GGNBP2	681	Q9H3C7
NLTAGKAEICPWEVG	GPR179	1696	Q6PRD1
KICPWEVSEGTTGKG	GPR179	1816	Q6PRD1
WTSCKSGAIESTAPA	KRT39	421	Q6A163
VRLDSWKGVASGCSP	KCNQ1DN	21	Q9H478
WKGVASGCSPSKASQ	KCNQ1DN	26	Q9H478
CVSSSSAIIAKPGEW	ARMC9	706	Q7Z3E5
CGWTKSPLFVGDRDS	JCAD	1151	Q9P266
EIGKWSPCSLTCGVG	ADAMTSL1	671	Q8N6G6
GIVSWGDVPCDNTTK	KLK15	221	Q9H2R5
SSGWISKCPDIQVLA	DDIAS	941	Q8IXT1
GPLVKSGETVILQCW	KIR3DL3	131	Q8N743
GCDWTDSKPTVETLG	NRP2	591	O60462
TKICWTVTRGEGLSP	DPY19L1	131	Q2PZI1
SAPKDVWVSGNLCGT	IL27RA	231	Q6UWB1
TWKRSSLCGEEQGSP	KIF7	1276	Q2M1P5
EGTKSSGLGACEWLL	NPHS2	91	Q9NP85
WSCDIGIGAKRSPST	KIAA0408	361	Q6ZU52
TSVCWSPKGKQLAVG	NUP214	196	P35658
NIWDGVTTKTFCGTP	PRKCB	491	P05771
AVTVDGWTPLHSACK	ANKRD49	136	Q8WVL7
DSPEDAWKGCKGSIQ	PLEKHA8	31	Q96JA3
SGGLWTECIAQLSPE	IPO5	1071	O00410
QRPSVSDDTGCGWKF	ITGB4	1361	P16144
CIAGPSLTGWTLVEV	GPR45	161	Q9Y5Y3
EVCPAGWKPGSDTIK	PRDX1	171	Q06830
IIGEIGCSWPLTESE	PTER	166	Q96BW5
CELSEPTATVVWSKG	OBSCN	3911	Q5VST9
CLSATPGGKEHLVWQ	ADCY2	176	Q08462
WSLSSCKPGFGVDQL	ANAPC10	31	Q9UM13
KTGPWSECSVTCGEG	ADAMTS3	971	O15072
VIVGTWGESLKLPCT	IGSF10	1851	Q6WRI0
APDGWSDLDGLLSCV	CARD14	971	Q9BXL6
LGSLTTPTCDEKVVW	CA4	221	P22748
GTEQGCWIPVSSDKG	EGF	1141	P01133
CIDSGLWVPNSKASE	CDC37	336	Q16543
AVGAKLTWEAVPGSE	FCGBP	376	Q9Y6R7
KCIAVGESDGSIWNP	GLUD1	326	P00367
DSKITSAVWGPLGEC	EIF3I	146	Q13347
HPTGESILCWEKVTE	CENPJ	286	Q9HC77
GTPGTVLDWCSKLKF	DDX19B	216	Q9UMR2
CSKGTTDAPVGSGLW	IGFL3	21	Q6UXB1
PAWKDGSTATCVLAV	ILKAP	211	Q9H0C8
GALTCATPGTWKDRQ	C1RL	206	Q9NZP8
IQTPSRGTKCWGVDF	ADAM9	591	Q13443
VNGPSKLECLASGIW	SELP	236	P16109
GFWTSSKGEKSLPVC	MASP2	416	O00187
WIKEGTCLAVGTSEG	CDC20B	281	Q86Y33
WIKRISGECGSSFPQ	HAUS6	96	Q7Z4H7
KCTVSGWGTVTSPRE	KLK8	151	O60259
WGKGVREIPASVCTL	GRM7	511	Q14831
SQTGPISLTVAKCWD	DVL1	326	O14640
SCTLTSDLGPGTWFK	IGFN1	476	Q86VF2
WICKQDGSPSTELVS	ELP2	66	Q6IA86
AETSGKDIWHPGERC	ERCC6L2	21	Q5T890
ATPCIKAISPSEGWT	EBF3	261	Q9H4W6
SQTGPISLTVAKCWD	DVL1P1	326	P54792
PGSSWELLQACGKLK	HPS1	461	Q92902
CGWGKPISESLESVR	SPACA1	121	Q9HBV2
ETEEIPQGASGCWKD	CCDC159	206	P0C7I6
KCIAVGESDGSIWNP	GLUD2	326	P49448
QGATKCVVAWPEDSG	TACR2	176	P21452
CVVAWPEDSGGKTLL	TACR2	181	P21452
SSLAASGICKKEPWE	GARNL3	466	Q5VVW2
VTKPGNWRDVCEGSA	GARIN1A	61	Q6NXP2
TWGDCKVGESSSRPA	GAREM2	556	Q75VX8
GPCGVTLKSLAWHTA	RTTN	1111	Q86VV8
VLPDLSGWSCSSGHK	TAFA3	111	Q7Z5A8
LPSDLLSWSCVGAEG	SLC35G5	246	Q96KT7
SEGGITCWEKICPLF	SLC6A6	106	P31641
TGCVLGSSGKVLPKW	POMT2	481	Q9UKY4
VGNWSDCILPEGKVE	THSD7A	966	Q9UPZ6
GASSPEFTKLCAWLV	FAM98A	36	Q8NCA5
GTGEPWCDVVLAILA	POGZ	1151	Q7Z3K3
WKACFVGLIESPEGT	MED24	286	O75448
GCIGVSGKTKWDVLD	NAV2	2041	Q8IVL1
WDKGTLTTAISNPAC	SMIM42	11	A0A5F9ZH02
WCTPGGASTIDFLKR	SETX	6	Q7Z333
TCAEKELPWKSGQGD	SLC9A5	756	Q14940
GKGEPVTELSWHSCR	SUPT7L	141	O94864
EWKNCIIVSPDAGGA	PRPS1L1	161	P21108
EGPSALTCLETGDWD	SVEP1	2531	Q4LDE5
TIPWVELGGKVSINC	OSBPL10	601	Q9BXB5
SQWKICGLDPTSTLG	SEC23B	446	Q15437
ELKSSWAKSGTGEVP	STK36	361	Q9NRP7
ERPICVSWSTDVKGG	ADGRE1	546	Q14246
DTALCKESPGLWGAS	AHNAK2	5421	Q8IVF2
PHWLSGKILCQTGVD	CLRN2	31	A0PK11
WDGEKTIIITCSFTP	PRPF8	2206	Q6P2Q9
FLNKTDGPLWECGTV	TECTA	526	O75443
VCPSDGCTWKGTLKE	TRAF2	106	Q12933
KPQLGDSSPVWSGVC	TMEM196	41	Q5HYL7
PECGKGFSWNSVLII	ZSCAN2	561	Q7Z7L9
SVGCWHGAKDEEVPS	ZNF749	46	O43361
LKVSLTSPATWCLGG	ZBP1	56	Q9H171
ATTGKAWDLAGVEPD	RBP3	901	P10745
EGWDSPICTEGVVSV	SECTM1	31	Q8WVN6
GGEVSWDKSLCIGAT	PES1	351	O00541
LSISKDLWPGCDVGE	RP1L1	1151	Q8IWN7
GSCGKVLVWPTEFSH	UGT2B4	21	P06133
VSWGSPDCVGLTETK	STIM2	646	Q9P246
EWKNCIIVSPDAGGA	PRPS2	161	P11908
LGLWSQGEETKPCSP	WDFY4	2271	Q6ZS81
EFPKLSCGEWKSLVG	THNSL1	271	Q8IYQ7
KGLECSDWKPEAGLS	TCEA3	101	O75764
GDKFKPVIGTWDCDT	NUP153	716	P49790
CKIWEEVAGELPGSQ	ZNF229	106	Q9UJW7
WSLATVATDLCLGPK	WDR59	696	Q6PJI9
IGTGWSCKIPNFDVR	TOP2A	856	P11388
KCTVDIGGLIIGWSS	ZNF507	446	Q8TCN5
AEKKSSCFIEWGLPG	ZMYM5	131	Q9UJ78
SEVKEACTWGSLALG	TEX13A	61	Q9BXU3
TPALTKHEWTEALGC	ZNF8	436	P17098
TEGLKESPVCTSGWY	TTC37	296	Q6PGP7
SWTESSINPGKCKAG	ZDHHC2	341	Q9UIJ5
VTDWTCGLSVLGPTD	ZNF746	626	Q6NUN9
PGCTWDSLRNSVGEK	TARBP2	261	Q15633
GSPKEKTLDCGQIVW	WSB2	81	Q9NYS7
DIGEWSECSKTCGLG	THSD4	681	Q6ZMP0
GGSKTSPALCQWSEV	UBR4	2156	Q5T4S7
EGKSSQGCPIAKWVV	TET2	1186	Q6N021
GVKTITWGITSCKAP	TRRAP	556	Q9Y4A5
VTWAPGLKNCLAISG	WDR73	281	Q6P4I2
SEVKEACTWGSLALG	TEX13B	61	Q9BXU2
VLEGIDLGPCTSKWT	TYW5	31	A2RUC4
PGSVREDSGFICWKK	ZFHX3	1351	Q15911
SIPLGKSWVSSGCTE	ZAN	2276	Q9Y493
LTLKWVDSEGDPCTV	PRKCZ	56	Q05513
PLGDKGLDTSCRWLS	NDE1	311	Q9NXR1