Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncoumarin 7-hydroxylase activity

CYP2A6 CYP2A7 CYP2A13

3.78e-083683GO:0008389
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

SMARCA5 WAPL POLA1 POLL POLQ RAD17 MPG

3.03e-05262687GO:0140097
GeneOntologyMolecularFunctionarachidonate epoxygenase activity

CYP2A6 CYP2A7 CYP2A13

7.26e-0524683GO:0008392
GeneOntologyMolecularFunctionDNA-directed DNA polymerase activity

POLA1 POLL POLQ

8.23e-0525683GO:0003887
GeneOntologyMolecularFunctionarachidonate monooxygenase activity

CYP2A6 CYP2A7 CYP2A13

1.04e-0427683GO:0008391
GeneOntologyMolecularFunctionsteroid hydroxylase activity

CYP2A6 CYP2A7 CYP2A13

2.10e-0434683GO:0008395
GeneOntologyMolecularFunctionaromatase activity

CYP2A6 CYP2A7 CYP2A13

2.29e-0435683GO:0070330
GeneOntologyMolecularFunctionDNA polymerase activity

POLA1 POLL POLQ

2.93e-0438683GO:0034061
GeneOntologyMolecularFunctionpreribosome binding

GTPBP4 NVL

3.16e-048682GO:1990275
GeneOntologyMolecularFunction5'-deoxyribose-5-phosphate lyase activity

POLL POLQ

3.16e-048682GO:0051575
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP2A6 CYP2A7 CYP2A13

6.22e-0449683GO:0016712
GeneOntologyMolecularFunctionaxon guidance receptor activity

ROBO1 ROBO2

8.70e-0413682GO:0008046
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

SMARCA5 WAPL POLQ RAD17

9.28e-04127684GO:0008094
GeneOntologyMolecularFunctionATP-dependent activity

SMARCA5 WAPL HYOU1 VWA8 NVL KIF3C POLQ RAD17

1.11e-03614688GO:0140657
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

SMARCA5 WAPL POLA1 POLL POLQ NOP2 RAD17 MPG

1.52e-03645688GO:0140640
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

TRPA1 RYR2

1.69e-0318682GO:0015278
GeneOntologyMolecularFunctioniron ion binding

CYP2A6 CYP2A7 CYP2A13 KDM7A

2.48e-03166684GO:0005506
GeneOntologyMolecularFunctionLRR domain binding

ROBO1 PAWR

2.53e-0322682GO:0030275
GeneOntologyMolecularFunctionubiquitin-like ligase-substrate adaptor activity

PRAMEF9 PRAMEF15 PRAMEF11

2.76e-0382683GO:1990756
GeneOntologyMolecularFunctionATP hydrolysis activity

SMARCA5 VWA8 NVL KIF3C POLQ RAD17

3.87e-03441686GO:0016887
GeneOntologyMolecularFunctionenzyme-substrate adaptor activity

PRAMEF9 PRAMEF15 PRAMEF11

4.18e-0395683GO:0140767
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

CYP2A6 CYP2A7 CYP2A13 KDM7A

4.33e-03194684GO:0016705
GeneOntologyMolecularFunctionligand-gated calcium channel activity

TRPA1 RYR2

4.99e-0331682GO:0099604
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

TRPA1 RYR2

5.64e-0333682GO:0005217
GeneOntologyBiologicalProcessmaturation of LSU-rRNA

GTPBP4 URB1 MAK16 NOP2

1.30e-0625684GO:0000470
GeneOntologyBiologicalProcessphenylpropanoid metabolic process

CYP2A6 CYP2A7 CYP2A13

4.05e-0610683GO:0009698
GeneOntologyBiologicalProcesscoumarin metabolic process

CYP2A6 CYP2A7 CYP2A13

4.05e-0610683GO:0009804
GeneOntologyBiologicalProcessribosomal large subunit biogenesis

GTPBP4 URB1 NVL MAK16 NOP2

4.23e-0673685GO:0042273
GeneOntologyBiologicalProcessnegative regulation of negative chemotaxis

ROBO1 ROBO2

1.07e-052682GO:0050925
GeneOntologyBiologicalProcessepoxygenase P450 pathway

CYP2A6 CYP2A7 CYP2A13

5.05e-0522683GO:0019373
GeneOntologyBiologicalProcessregulation of negative chemotaxis

ROBO1 ROBO2

6.40e-054682GO:0050923
GeneOntologyBiologicalProcessDNA replication

GTPBP4 SMARCA5 WAPL POLA1 POLL POLQ RAD17

7.45e-05312687GO:0006260
GeneOntologyBiologicalProcessrRNA processing

GTPBP4 URB1 UTP18 NVL MAK16 NOP2

1.11e-04230686GO:0006364
GeneOntologyBiologicalProcessnegative regulation of DNA replication

GTPBP4 WAPL RAD17

1.18e-0429683GO:0008156
GeneOntologyBiologicalProcessDNA metabolic process

GTPBP4 SMARCA5 WAPL POLA1 NVL SPIRE1 POLL TAF2 DOT1L POLQ RAD17 MPG

1.94e-0410816812GO:0006259
GeneOntologyBiologicalProcessnegative regulation of mammary gland epithelial cell proliferation

GATA3 ROBO1

2.23e-047682GO:0033600
GeneOntologyBiologicalProcessaxon midline choice point recognition

ROBO1 ROBO2

2.23e-047682GO:0016199
GeneOntologyBiologicalProcessDNA repair

SMARCA5 POLA1 SPIRE1 POLL TAF2 DOT1L POLQ RAD17 MPG

2.66e-04648689GO:0006281
GeneOntologyBiologicalProcessaortic valve morphogenesis

GATA3 ROBO1 ROBO2

2.88e-0439683GO:0003180
GeneOntologyBiologicalProcessrRNA metabolic process

GTPBP4 URB1 UTP18 NVL MAK16 NOP2

2.91e-04275686GO:0016072
GeneOntologyBiologicalProcessheart induction

ROBO1 ROBO2

2.96e-048682GO:0003129
GeneOntologyBiologicalProcesspositive regulation of animal organ morphogenesis

GATA3 ROBO1 ROBO2

3.34e-0441683GO:0110110
GeneOntologyBiologicalProcessregulation of heart morphogenesis

ROBO1 ROBO2

3.80e-049682GO:2000826
GeneOntologyBiologicalProcessaxon choice point recognition

ROBO1 ROBO2

3.80e-049682GO:0016198
GeneOntologyBiologicalProcessaortic valve development

GATA3 ROBO1 ROBO2

4.70e-0446683GO:0003176
GeneOntologyBiologicalProcessbase-excision repair

POLL POLQ MPG

4.70e-0446683GO:0006284
GeneOntologyBiologicalProcesspolar body extrusion after meiotic divisions

WASH6P SPIRE1

4.74e-0410682GO:0040038
GeneOntologyBiologicalProcessregulation of DNA metabolic process

GTPBP4 SMARCA5 WAPL NVL SPIRE1 TAF2 POLQ RAD17

5.20e-04564688GO:0051052
GeneOntologyBiologicalProcessolfactory bulb interneuron development

ROBO1 ROBO2

5.78e-0411682GO:0021891
GeneOntologyBiologicalProcesssemi-lunar valve development

GATA3 ROBO1 ROBO2

6.01e-0450683GO:1905314
MousePhenoabnormal spinal cord lateral column morphology

ROBO1 ROBO2

1.63e-052572MP:0009678
MousePhenodecreased intestinal cholesterol absorption

CYP2A6 CYP2A7 CYP2A13

4.20e-0517573MP:0002647
MousePhenoabnormal intestinal cholesterol absorption

CYP2A6 CYP2A7 CYP2A13

5.95e-0519573MP:0002645
DomainCyt_P450_E_grp-I_CYP2A-like

CYP2A6 CYP2A7 CYP2A13

1.68e-074663IPR008067
DomainAUTS2

FBRSL1 AUTS2

3.68e-053662IPR023246
DomainCyt_P450_E_grp-I

CYP2A6 CYP2A7 CYP2A13

5.38e-0445663IPR002401
DomainITAM_1

CD247 NFAM1

5.43e-0410662PS51055
DomainPhos_immunorcpt_sig_ITAM

CD247 NFAM1

5.43e-0410662IPR003110
DomainCyt_P450_CS

CYP2A6 CYP2A7 CYP2A13

8.70e-0453663IPR017972
DomainCYTOCHROME_P450

CYP2A6 CYP2A7 CYP2A13

1.08e-0357663PS00086
Domain-

CYP2A6 CYP2A7 CYP2A13

1.13e-03586631.10.630.10
Domainp450

CYP2A6 CYP2A7 CYP2A13

1.13e-0358663PF00067
DomainCyt_P450

CYP2A6 CYP2A7 CYP2A13

1.25e-0360663IPR001128
DomainPRAME_family

PRAMEF25 PRAMEF15

2.02e-0319662IPR026271
DomainAAA

VWA8 NVL

6.41e-0334662PS00674
DomainGlyco_hydro_catalytic_dom

HPSE HECA

7.97e-0338662IPR013781
PathwayREACTOME_CYP2E1_REACTIONS

CYP2A6 CYP2A7 CYP2A13

6.00e-0611483M27130
PathwayREACTOME_CYP2E1_REACTIONS

CYP2A6 CYP2A7 CYP2A13

7.98e-0612483MM14847
PathwayREACTOME_FATTY_ACIDS

CYP2A6 CYP2A7 CYP2A13

2.92e-0518483MM14841
PathwayREACTOME_XENOBIOTICS

CYP2A6 CYP2A7 CYP2A13

6.25e-0523483M5372
PathwayREACTOME_XENOBIOTICS

CYP2A6 CYP2A7 CYP2A13

8.08e-0525483MM14846
PathwayKEGG_MEDICUS_ENV_FACTOR_NNK_TO_DNA_ADDUCTS

CYP2A6 CYP2A13

1.13e-045482M47808
PathwayREACTOME_REGULATION_OF_COMMISSURAL_AXON_PATHFINDING_BY_SLIT_AND_ROBO

ROBO1 ROBO2

5.02e-0410482M27348
PathwayKEGG_DRUG_METABOLISM_OTHER_ENZYMES

CYP2A6 CYP2A7 CYP2A13

6.88e-0451483M17726
Pubmed

Functional proteomic analysis of human nucleolus.

GTPBP4 URB1 UTP18 NVL MAK16 RBM28 NOP2

1.85e-0910669712429849
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

GTPBP4 URB1 SMARCA5 UTP18 HYOU1 POLA1 NVL MAK16 RBM28 NOP2 ZMYM3 RAI1

5.77e-09653691222586326
Pubmed

Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.

CYP2A6 CYP2A7 CYP2A13

7.47e-09369331645370
Pubmed

Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.

CYP2A6 CYP2A7 CYP2A13

7.47e-0936933346244
Pubmed

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.

CYP2A6 CYP2A7 CYP2A13

7.47e-0936932733794
Pubmed

A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.

CYP2A6 CYP2A7 CYP2A13

7.47e-0936938297477
Pubmed

Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.

CYP2A6 CYP2A7 CYP2A13

7.47e-0936938188299
Pubmed

Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.

CYP2A6 CYP2A7 CYP2A13

7.47e-0936938484736
Pubmed

Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.

CYP2A6 CYP2A7 CYP2A13

7.47e-0936938250953
Pubmed

The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.

CYP2A6 CYP2A7 CYP2A13

7.47e-0936932703500
Pubmed

Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.

CYP2A6 CYP2A7 CYP2A13

7.47e-0936931417950
Pubmed

Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.

CYP2A6 CYP2A7 CYP2A13

7.47e-09369324045421
Pubmed

Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.

CYP2A6 CYP2A7 CYP2A13

7.47e-09369332987105
Pubmed

Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.

CYP2A6 CYP2A7 CYP2A13

7.47e-09369322217847
Pubmed

Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.

CYP2A6 CYP2A7 CYP2A13

7.47e-0936932765478
Pubmed

Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.

CYP2A6 CYP2A7 CYP2A13

7.47e-0936932415518
Pubmed

Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.

CYP2A6 CYP2A7 CYP2A13

7.47e-09369322890016
Pubmed

Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver.

CYP2A6 CYP2A7 CYP2A13

2.99e-0846939408084
Pubmed

Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP.

CYP2A6 CYP2A7 CYP2A13

2.99e-08469310490589
Pubmed

Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice.

CYP2A6 CYP2A7 CYP2A13

2.99e-0846931970547
Pubmed

A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.

CYP2A6 CYP2A7 CYP2A13

2.99e-0846937565685
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

GTPBP4 SMARCA5 WAPL POLA1 NVL TAF2 DOT1L NOP2 ZMYM3 RAI1 MPG

3.10e-08608691136089195
Pubmed

The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.

GTPBP4 URB1 SMARCA5 UTP18 NVL MAK16 RBM28 NOP2 RAI1

3.11e-0834969925665578
Pubmed

A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.

CYP2A6 CYP2A7 CYP2A13

1.49e-0766937668294
Pubmed

Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19.

CYP2A6 CYP2A7 CYP2A13

1.49e-0766938587134
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

URB1 WAPL HYOU1 MAP6 PRAMEF15 ARID5B SPIRE1 RBM28 DOT1L BAIAP3 VPS13B PRAMEF11 RAD17

1.87e-071084691311544199
Pubmed

Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster.

CYP2A6 CYP2A7 CYP2A13

2.60e-07769314630516
Pubmed

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.

CYP2A6 CYP2A7 CYP2A13

2.60e-0776939630227
Pubmed

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

CEP350 GTPBP4 URB1 SMARCA5 UTP18 NVL MAK16 RBM28 NOP2

4.83e-0748369936912080
Pubmed

Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder.

CYP2A6 CYP2A7 CYP2A13

6.22e-07969337838304
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

WAPL VWA8 FBRSL1 AUTS2 SPIRE1 ROBO2 KDM7A ACAP2 RAI1

1.03e-0652969914621295
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

GTPBP4 URB1 SMARCA5 WAPL UTP18 POLA1 TAF2 RBM28 NOP2 BAG6 ZMYM3 AHNAK2 MPG

2.24e-061353691329467282
Pubmed

Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism.

CYP2A6 CYP2A7 CYP2A13

3.34e-061569329968852
Pubmed

Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.

CYP2A6 CYP2A7

3.88e-06269212325023
Pubmed

Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.

CYP2A6 CYP2A13

3.88e-06269222696418
Pubmed

Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice.

CYP2A6 CYP2A13

3.88e-06269230876690
Pubmed

Robo signaling regulates the production of cranial neural crest cells.

ROBO1 ROBO2

3.88e-06269228987541
Pubmed

CYP2A5 induction and hepatocellular stress: an adaptive response to perturbations of heme homeostasis.

CYP2A6 CYP2A13

3.88e-06269221395539
Pubmed

Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions.

CYP2A6 CYP2A13

3.88e-06269212162851
Pubmed

Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh.

CYP2A6 CYP2A13

3.88e-0626921302041
Pubmed

Structural alteration of mouse P450coh by mutation of glycine-207 to proline: spin equilibrium, enzyme kinetics, and heat sensitivity.

CYP2A6 CYP2A13

3.88e-0626928395817
Pubmed

Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice.

CYP2A6 CYP2A13

3.88e-06269225804444
Pubmed

Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression.

CYP2A6 CYP2A13

3.88e-0626921520280
Pubmed

Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.

CYP2A6 CYP2A13

3.88e-06269223917075
Pubmed

Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5.

CYP2A6 CYP2A13

3.88e-06269230222954
Pubmed

CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.

CYP2A6 CYP2A7

3.88e-06269216636685
Pubmed

Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver.

CYP2A6 CYP2A13

3.88e-0626927543189
Pubmed

Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.

CYP2A6 CYP2A13

3.88e-06269227902773
Pubmed

Characterization and regulation of sex-specific mouse steroid hydroxylase genes.

CYP2A6 CYP2A13

3.88e-0626922372744
Pubmed

A Spatiotemporal Sequence of Sensitization to Slits and Semaphorins Orchestrates Commissural Axon Navigation.

ROBO1 ROBO2

3.88e-06269231597096
Pubmed

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.

CYP2A6 CYP2A7

3.88e-0626922322567
Pubmed

Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.

CYP2A6 CYP2A13

3.88e-06269221473878
Pubmed

The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.

CYP2A6 CYP2A13

3.88e-0626927581481
Pubmed

Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ.

CYP2A6 CYP2A13

3.88e-06269230154104
Pubmed

Expression of CYP2A genes in human liver and extrahepatic tissues.

CYP2A7 CYP2A13

3.88e-06269210353262
Pubmed

Expression and alternative splicing of the cytochrome P-450 CYP2A7.

CYP2A6 CYP2A7

3.88e-0626927864805
Pubmed

Robo1 and Robo2 are homophilic binding molecules that promote axonal growth.

ROBO1 ROBO2

3.88e-06269212504588
Pubmed

Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver.

CYP2A6 CYP2A13

3.88e-06269228298240
Pubmed

Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice.

CYP2A6 CYP2A13

3.88e-0626926309775
Pubmed

Endocrine cell type sorting and mature architecture in the islets of Langerhans require expression of Roundabout receptors in β cells.

ROBO1 ROBO2

3.88e-06269230022126
Pubmed

Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo.

CYP2A6 CYP2A13

3.88e-06269221418183
Pubmed

Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.

CYP2A6 CYP2A13

3.88e-06269222262919
Pubmed

Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.

CYP2A6 CYP2A13

3.88e-06269225635819
Pubmed

Robo1/2 regulate follicle atresia through manipulating granulosa cell apoptosis in mice.

ROBO1 ROBO2

3.88e-06269225988316
Pubmed

Genetic variation between mice in their metabolism of coumarin and its derivatives.

CYP2A6 CYP2A13

3.88e-062692566237
Pubmed

Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model.

CYP2A6 CYP2A13

3.88e-06269219923441
Pubmed

Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression.

CYP2A6 CYP2A13

3.88e-06269212499123
Pubmed

Whole-exome and targeted sequencing identify ROBO1 and ROBO2 mutations as progression-related drivers in myelodysplastic syndromes.

ROBO1 ROBO2

3.88e-06269226608094
Pubmed

Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors.

ROBO1 ROBO2

3.88e-0626929458045
Pubmed

Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization.

CYP2A6 CYP2A13

3.88e-0626928611142
Pubmed

Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver.

CYP2A6 CYP2A13

3.88e-06269222497566
Pubmed

Coumarin toxicity in different strains of mice.

CYP2A6 CYP2A13

3.88e-062692665441
Pubmed

Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.

CYP2A6 CYP2A13

3.88e-06269224104196
Pubmed

Frameshift mutations of axon guidance genes ROBO1 and ROBO2 in gastric and colorectal cancers with microsatellite instability.

ROBO1 ROBO2

3.88e-06269224247621
Pubmed

An ancient founder mutation located between ROBO1 and ROBO2 is responsible for increased microtia risk in Amerindigenous populations.

ROBO1 ROBO2

3.88e-06269235584116
Pubmed

The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.

CYP2A6 CYP2A13

3.88e-06269226363552
Pubmed

Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes.

CYP2A6 CYP2A13

3.88e-0626922712571
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

GTPBP4 URB1 SMARCA5 UTP18 NVL MAK16 RBM28

4.41e-0633269725693804
Pubmed

Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.

CYP2A6 CYP2A7 CYP2A13

4.98e-061769327197076
Pubmed

Interaction network of human early embryonic transcription factors.

SMARCA5 HYOU1 ARID5B FBRSL1 AUTS2 ZMYM3 RAI1

6.34e-0635169738297188
Pubmed

Molecular genetics of the human cytochrome P450 monooxygenase superfamily.

CYP2A6 CYP2A7 CYP2A13

8.32e-06206939890157
Pubmed

Presenilin-dependent receptor processing is required for axon guidance.

GATA3 ROBO1 ROBO2

9.69e-062169321215373
Pubmed

RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity.

GTPBP4 SMARCA5 WAPL ARID5B NVL

1.10e-0514669521589869
Pubmed

Robo family of proteins exhibit differential expression in mouse spinal cord and Robo-Slit interaction is required for midline crossing in vertebrate spinal cord.

ROBO1 ROBO2

1.16e-05369215768400
Pubmed

Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes.

CYP2A6 CYP2A13

1.16e-05369218602936
Pubmed

Rab35 protein regulates evoked exocytosis of endothelial Weibel-Palade bodies.

TBC1D10A ACAP2

1.16e-05369228566286
Pubmed

Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress.

CYP2A6 CYP2A13

1.16e-05369218068688
Pubmed

CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.

CYP2A6 CYP2A7

1.16e-05369211960914
Pubmed

Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA.

CYP2A6 CYP2A13

1.16e-0536923219345
Pubmed

Rig-1 a new member of Robo family genes exhibits distinct pattern of expression during mouse development.

ROBO1 ROBO2

1.16e-05369214678835
Pubmed

Dynamic expression patterns of Robo (Robo1 and Robo2) in the developing murine central nervous system.

ROBO1 ROBO2

1.16e-05369214689480
Pubmed

Zfp30, a KRAB domain containing zinc finger protein gene, maps to mouse chromosome 7.

CYP2A6 CYP2A13

1.16e-0536927849402
Pubmed

Human placental multipotent mesenchymal stromal cells modulate placenta angiogenesis through Slit2-Robo signaling.

ROBO1 ROBO2

1.16e-05369226745454
Pubmed

Slit2-Robo Signaling Promotes Glomerular Vascularization and Nephron Development.

ROBO1 ROBO2

1.16e-05369234341180
Pubmed

Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.

CYP2A6 CYP2A13

1.16e-05369220840855
Pubmed

Robos are required for the correct targeting of retinal ganglion cell axons in the visual pathway of the brain.

ROBO1 ROBO2

1.16e-05369218272390
Pubmed

Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway.

CYP2A6 CYP2A13

1.16e-05369222552773
Pubmed

Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases.

DOT1L BAG6

1.16e-05369222373577
Pubmed

Robo1 and Robo2 have distinct roles in pioneer longitudinal axon guidance.

ROBO1 ROBO2

1.16e-05369221820427
Pubmed

Limited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital.

CYP2A6 CYP2A13

1.16e-05369211106424
InteractionCYP2A7 interactions

CYP2A6 CYP2A7 CYP2A13

3.67e-083683int:CYP2A7
InteractionMNDA interactions

GTPBP4 URB1 UTP18 NVL MAK16 RBM28 NOP2

3.30e-06188687int:MNDA
InteractionPOLR1G interactions

GTPBP4 URB1 UTP18 NVL TAF2 RBM28 DOT1L NOP2 ZMYM3 RAI1

5.32e-064896810int:POLR1G
InteractionZNF48 interactions

GTPBP4 URB1 NVL MAK16 RBM28 NOP2

1.11e-05149686int:ZNF48
InteractionMAGEB2 interactions

GTPBP4 URB1 SMARCA5 UTP18 NVL MAK16 RBM28 NOP2

2.23e-05349688int:MAGEB2
InteractionPWP2 interactions

GTPBP4 WAPL UTP18 RBM28 DOT1L BAG6

2.50e-05172686int:PWP2
InteractionRRP8 interactions

GTPBP4 URB1 NVL MAK16 RBM28 DOT1L NOP2

2.65e-05259687int:RRP8
InteractionNPM3 interactions

GTPBP4 URB1 NVL MAK16 RBM28 DOT1L NOP2

2.86e-05262687int:NPM3
InteractionSIRT7 interactions

GTPBP4 URB1 UTP18 HYOU1 POLA1 NVL MAK16 RBM28 NOP2 ZMYM3 RAI1

3.63e-057446811int:SIRT7
InteractionSRPK3 interactions

GTPBP4 URB1 NVL MAK16 RBM28 NOP2

4.37e-05190686int:SRPK3
InteractionTEK interactions

GTPBP4 SMARCA5 HYOU1 RBM28 BAG6

5.11e-05119685int:TEK
InteractionRBM34 interactions

GTPBP4 URB1 NVL MAK16 RBM28 DOT1L NOP2

5.44e-05290687int:RBM34
InteractionMST1R interactions

SMARCA5 HYOU1 POLA1 DOT1L NOP2 BAG6

5.82e-05200686int:MST1R
InteractionDNAJC9 interactions

GTPBP4 UTP18 HYOU1 NVL RBM28 DOT1L NOP2

6.19e-05296687int:DNAJC9
InteractionNOP2 interactions

GTPBP4 URB1 NVL MAK16 RBM28 DOT1L NOP2 BAG6

7.72e-05416688int:NOP2
InteractionMACROH2A2 interactions

GTPBP4 URB1 MAK16 RBM28 NOP2 RAD17

7.82e-05211686int:MACROH2A2
InteractionEBNA1BP2 interactions

GTPBP4 CYP2A6 CYP2A13 MAK16 RBM28 DOT1L NOP2

1.09e-04324687int:EBNA1BP2
InteractionRPP30 interactions

GTPBP4 UTP18 VWA8 NVL DOT1L

1.14e-04141685int:RPP30
InteractionWDFY4 interactions

HYOU1 VWA8 ACAP2 BAG6 AHNAK2

1.14e-04141685int:WDFY4
InteractionZNF330 interactions

GTPBP4 URB1 SMARCA5 NVL RBM28 NOP2 ZMYM3 RAI1

1.25e-04446688int:ZNF330
InteractionZBTB47 interactions

GTPBP4 NVL MAK16 RBM28 PNMA3

1.26e-04144685int:ZBTB47
InteractionGPATCH4 interactions

GTPBP4 NVL MAK16 RBM28 DOT1L NOP2

1.32e-04232686int:GPATCH4
InteractionIFI16 interactions

GTPBP4 URB1 SMARCA5 UTP18 NVL MAK16 RBM28 DOT1L ACAP2 NOP2

1.33e-047146810int:IFI16
InteractionRNF2 interactions

GTPBP4 SMARCA5 SOWAHA UTP18 HYOU1 GATA3 FBRSL1 AUTS2 RBM28 NOP2 ZMYM3

1.41e-048666811int:RNF2
InteractionRPL3 interactions

GTPBP4 URB1 UTP18 NVL MAK16 RBM28 DOT1L NOP2 RAI1 AHNAK2

1.45e-047226810int:RPL3
InteractionCYP2A13 interactions

CYP2A7 CYP2A13

1.67e-046682int:CYP2A13
InteractionNOL12 interactions

GTPBP4 MAK16 RBM28 DOT1L NOP2

1.68e-04153685int:NOL12
InteractionUSP36 interactions

CEP350 GTPBP4 URB1 SMARCA5 UTP18 NVL MAK16 RBM28 NOP2

1.76e-04599689int:USP36
InteractionMAK16 interactions

GTPBP4 NVL MAK16 RBM28 NOP2

2.19e-04162685int:MAK16
InteractionFGFBP1 interactions

GTPBP4 URB1 SMARCA5 UTP18 MAK16 RBM28

2.29e-04257686int:FGFBP1
InteractionAATF interactions

GTPBP4 UTP18 NVL PAWR RBM28 DOT1L NOP2

2.71e-04376687int:AATF
InteractionCENPA interactions

GTPBP4 URB1 SMARCA5 DOT1L NOP2 ZMYM3 RAI1

2.76e-04377687int:CENPA
InteractionSRSF6 interactions

GTPBP4 URB1 UTP18 NVL MAK16 RBM28 DOT1L NOP2

2.83e-04503688int:SRSF6
InteractionRPL18 interactions

GTPBP4 URB1 NVL AUTS2 RBM28 DOT1L NOP2 AHNAK2

3.19e-04512688int:RPL18
InteractionFLT1 interactions

URB1 SMARCA5 HYOU1 RBM28 PGF

3.47e-04179685int:FLT1
InteractionZNF467 interactions

GTPBP4 URB1 NVL RBM28 NOP2

3.47e-04179685int:ZNF467
InteractionDOT1L interactions

GTPBP4 URB1 SMARCA5 WAPL GATA3 RBM28 DOT1L NOP2 BAG6 ZMYM3

3.55e-048076810int:DOT1L
InteractionCEBPZ interactions

GTPBP4 MAK16 RBM28 DOT1L NOP2 BAG6

3.70e-04281686int:CEBPZ
InteractionCYP2A6 interactions

CYP2A6 CYP2A7

3.98e-049682int:CYP2A6
InteractionUTP23 interactions

GTPBP4 SMARCA5 MAK16 RBM28 NOP2

4.66e-04191685int:UTP23
InteractionFGF8 interactions

GTPBP4 URB1 NVL RBM28

4.88e-04108684int:FGF8
InteractionPPAN interactions

GTPBP4 SMARCA5 NVL RBM28 DOT1L

4.89e-04193685int:PPAN
InteractionRSL24D1 interactions

GTPBP4 MAK16 RBM28 DOT1L

5.23e-04110684int:RSL24D1
InteractionSURF6 interactions

GTPBP4 URB1 UTP18 MAK16 RBM28 DOT1L NOP2

5.73e-04426687int:SURF6
InteractionMRTO4 interactions

GTPBP4 UTP18 NVL DOT1L NOP2

5.75e-04200685int:MRTO4
InteractionSLIT3 interactions

ROBO1 ROBO2

6.05e-0411682int:SLIT3
InteractionRPL26L1 interactions

GTPBP4 URB1 NVL MAK16 RBM28 DOT1L NOP2

6.14e-04431687int:RPL26L1
InteractionNIFK interactions

GTPBP4 URB1 UTP18 NVL MAK16 RBM28 NOP2

6.14e-04431687int:NIFK
InteractionMEN1 interactions

GTPBP4 URB1 SMARCA5 WAPL POLA1 GATA3 NVL RBM28 DOT1L NOP2 ZMYM3

6.16e-0410296811int:MEN1
InteractionNOP56 interactions

GTPBP4 URB1 UTP18 HYOU1 RBM28 DOT1L NOP2 PNMA3

6.48e-04570688int:NOP56
InteractionMAGEA9 interactions

UTP18 ZNF611 TAF2 POLQ RAD17

6.87e-04208685int:MAGEA9
InteractionH2BC8 interactions

SMARCA5 WAPL POLA1 ARID5B NVL ZMYM3 RAI1 MPG

6.94e-04576688int:H2BC8
InteractionRBM4 interactions

GTPBP4 URB1 NVL RBM28 DOT1L NOP2

7.20e-04319686int:RBM4
Cytoband1p36.21

PRAMEF25 PRAMEF9 PRAMEF15 PRAMEF11

2.60e-06636941p36.21
Cytoband8q22.2

RGS22 VPS13B

5.52e-04236928q22.2
Cytoband19q13.2

CYP2A6 CYP2A7 CYP2A13

1.97e-0316469319q13.2
GeneFamilyPRAME family

PRAMEF25 PRAMEF9 PRAMEF15 PRAMEF11

4.10e-0724474686
GeneFamilyDNA polymerases

POLA1 POLL POLQ

2.81e-0523473535
GeneFamilyCytochrome P450 family 2

CYP2A6 CYP2A7 CYP2A13

1.02e-04354731001
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HNBML5

MAP6 GATA3 AUTS2 ROBO1 ROBO2 DOT1L TMEM132B RYR2 SLC12A5

3.14e-06465689M39066
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

MAP6 GPR158 UGCG GATA3 AUTS2 ROBO1 ROBO2 KIF3C TMEM132B RYR2 RAI1 AHNAK2 SLC12A5

4.54e-0611066813M39071
CoexpressionWENG_POR_DOSAGE

CYP2A6 CYP2A7 CYP2A13

6.45e-0530683MM1199
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_G_UP

CYP2A6 CYP2A7 CYP2A13 ARID5B SPIRE1 POLQ

6.81e-05267686MM984
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

CEP350 SMARCA5 WAPL UTP18 UGCG ARID5B NVL PAWR ACAP2 VPS13B

6.85e-058566810M4500
CoexpressionSMID_BREAST_CANCER_LUMINAL_B_UP

CYP2A6 TRPA1 UGCG GATA3 BAIAP3

7.88e-05169685M12892
CoexpressionLEE_BMP2_TARGETS_DN

GTPBP4 URB1 SMARCA5 UTP18 NVL MAK16 TAF2 DOT1L NOP2 RAD17

1.08e-049046810M2325
CoexpressionLEE_BMP2_TARGETS_DN

GTPBP4 URB1 SMARCA5 UTP18 NVL MAK16 TAF2 DOT1L NOP2 RAD17

1.26e-049226810MM1068
CoexpressionGSE17301_IFNA2_VS_IFNA5_STIM_ACD3_ACD28_ACT_CD8_TCELL_UP

CD247 WAPL ARID5B KIF3C HECA

1.66e-04198685M8036
CoexpressionGSE3982_DC_VS_TH2_DN

HYOU1 ARID5B GATA3 POLQ RYR2

1.70e-04199685M5486
CoexpressionGSE6674_UNSTIM_VS_ANTI_IGM_AND_CPG_STIM_BCELL_DN

GTPBP4 URB1 UTP18 MAK16 NOP2

1.70e-04199685M6926
CoexpressionGSE16385_IFNG_TNF_VS_UNSTIM_MACROPHAGE_ROSIGLITAZONE_TREATED_DN

CEP350 AUTS2 ROBO1 KDM7A VPS13B

1.74e-04200685M8032
CoexpressionGSE35435_RESTING_VS_IL4_TREATED_MACROPHAGE_UP

VWA8 TMA7 GATA3 AUTS2 NOP2

1.74e-04200685M9542
CoexpressionGSE22886_UNSTIM_VS_STIM_MEMORY_TCELL_DN

SMARCA5 POLA1 TAF2 HPSE NOP2

1.74e-04200685M4410
CoexpressionHOFT_CD4_POSITIVE_ALPHA_BETA_MEMORY_T_CELL_BCG_VACCINE_AGE_18_45YO_ID_56D_TOP_100_DEG_AFTER_IN_VITRO_RE_STIMULATION_UP

HYOU1 PNPLA7 RAI1

1.78e-0442683M41180
CoexpressionKUMAR_TARGETS_OF_MLL_AF9_FUSION

CYP2A6 CYP2A7 CYP2A13 PRAMEF15 GATA3 PRAMEF11 HDC

1.96e-04463687MM1011
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

CEP350 WAPL UTP18 UGCG ARID5B NVL PAWR

2.04e-04466687M13522
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

UGCG GATA3 ROBO1 ROBO2 PGF

6.15e-06167695b4ef07117d14da3d5fbced949e4dfcb01c392295
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

UGCG GATA3 ROBO1 ROBO2 PGF

6.15e-0616769594fc7df7ca55cd722a8dbd153201a29891217473
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

UGCG GATA3 ROBO1 ROBO2 PGF

6.15e-06167695eff3723fe60755272eca237459165e436e919ece
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAP6 ARID5B GATA3 ACAP2 HDC

6.34e-061686953bddf411a60137a8883fc9e77586e4719b0d6067
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAP6 ARID5B GATA3 ACAP2 HDC

6.34e-06168695b6d948857ee652351ddbe383b75fdd1721cd8721
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

UGCG AUTS2 ROBO1 PAWR ALPK2

1.09e-05188695b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

UGCG AUTS2 ROBO1 PAWR ALPK2

1.09e-05188695874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GPR158 ROBO2 TMEM132B RYR2 SLC12A5

1.40e-051986954ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCelldroplet-Lung-nan-3m-Lymphocytic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD247 UGCG GATA3 BAIAP3

1.03e-04157694b337937a88f62030114a28d70a63168417672767
ToppCellfacs-MAT-Fat-18m-Lymphocytic-NK_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD247 UGCG GATA3 BAIAP3

1.03e-04157694e6846ffd1bb18bf0469bc6d49ab6cf3533d9cde6
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD247 UGCG GATA3 BAIAP3

1.06e-041586949f0987eaf1766aadb5714b68df7a5d310ea5a57a
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

GPR158 ROBO2 TMEM132B RYR2

1.09e-041596945335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellfacs-GAT-Fat-18m-Lymphocytic-NK_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD247 UGCG GATA3 BAIAP3

1.09e-04159694796e63f6052189106359a4e01eae3e466bf1d593
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD247 UGCG GATA3 BAIAP3

1.09e-0415969494bc6ab248a8f02ccbc0facd24e0c7e9fda687d2
ToppCelldroplet-Lung-30m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD247 UGCG GATA3 BAIAP3

1.14e-04161694cd4a736d0cec31477c6e8d3b07a04ede1559854b
ToppCelldroplet-Lung-30m-Hematologic-Lymphocytic_NK_ILC|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD247 UGCG GATA3 BAIAP3

1.14e-0416169428930ba576625b98cc15993d1499e9dc5edbb5a9
ToppCelldroplet-Lung-30m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-natural_killer|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD247 UGCG GATA3 BAIAP3

1.17e-04162694ccba6d8d644fe56060ad388ec3a062b7e3b9f086
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_4|356C / Donor, Lineage, Cell class and subclass (all cells)

SPIRE1 POLQ NFAM1 ZMYM3

1.17e-041626947d43d59531cbefe3ac94953b7faf7156b2a31441
ToppCellfacs-GAT-Fat-24m-Lymphocytic-NK_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD247 UGCG GATA3 BAIAP3

1.19e-04163694e58863a462cc504bced627f004a47890ee2307ce
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD247 UGCG GATA3 BAIAP3

1.22e-041646949fed5df40f50bde35db8bf89c291cbdc0e104112
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD247 UGCG GATA3 BAIAP3

1.22e-04164694e712d6b89461f741dbd773ba9a27ecaddf97cbaa
ToppCelldroplet-Spleen-SPLEEN-1m-Lymphocytic-NK_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD247 UGCG GATA3 BAIAP3

1.25e-041656948741df8066a44c841752a99ad306d26ea68f5344
ToppCelldroplet-Lung-nan-21m-Lymphocytic-NK_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD247 UGCG GATA3 BAIAP3

1.28e-04166694325ece9d7dad2b92eeb4defa109853660ac133ca
ToppCelldroplet-Lung-nan-21m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD247 UGCG GATA3 BAIAP3

1.28e-04166694be45610f2fe606c328f5688189be40df5e678557
ToppCelldroplet-Lung-1m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-natural_killer|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD247 UGCG GATA3 BAIAP3

1.31e-04167694895844a45721988788d01120eb880603ba3ca139
ToppCellfacs-Spleen-nan-3m-Lymphocytic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD247 UGCG GATA3 BAIAP3

1.34e-0416869474dc46738f1d0a448df6c9b8288b515d92697792
ToppCellASK428-Immune-Mast_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

ROBO1 PNMA3 HDC AHNAK2

1.34e-04168694c399fcb4d1d0be48026c2ecabc34a5935e7adf73
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SOWAHA RGS22 GATA3 BAIAP3

1.34e-041686949a8709d34865cfa668d8f3335dc34fc86fc32482
ToppCelldroplet-Liver-LIVER_HEP-30m-Lymphocytic-NK/T|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD247 MAP6 GATA3 BAIAP3

1.40e-04170694aff226a84e397ab58204325aa9d8b396a881986e
ToppCelldroplet-Liver-LIVER_HEP-30m-Lymphocytic-NK_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD247 MAP6 GATA3 BAIAP3

1.40e-041706946af16e6f276aec6389ece99505ba13c7edc4c4fa
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GATA3 ROBO1 ROBO2 PGF

1.47e-0417269408a3fe536b1b064c5ee7779bc2b1115a5963a26b
ToppCellCOVID-19-kidney-PEC|kidney / Disease (COVID-19 only), tissue and cell type

AUTS2 ROBO2 PAWR ALPK2

1.47e-0417269436a96714a0eb6ac438648135336c9791881ddadb
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GATA3 ROBO1 ROBO2 PGF

1.47e-04172694553701349444eb366df3c11f54bb093434f153c6
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l9|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CD247 MAP6 AGBL2 BAIAP3

1.50e-0417369415a77f6aac968b7a1afea4f60aedbb95b9d0f765
ToppCellPCW_05-06-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

MAP6 BAIAP3 HDC SLC12A5

1.57e-041756949941c35601134d88d1b3249c81f8b43a8fc61610
ToppCellCOPD-Lymphoid-ILC_A|COPD / Disease state, Lineage and Cell class

CD247 GATA3 ZNF611 AUTS2

1.60e-04176694484452cb38fe4604f0910a068361ed461b5b0c21
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-BM_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD247 MAP6 GATA3 PAWR

1.68e-04178694888add8935ef3aef9b6693c5698e9d1842e66337
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD247 MAP6 GATA3 PAWR

1.68e-0417869443eda32af2e5e28a92421612d0a4c21e5427a772
ToppCellHealthy_Control-Lymphoid-NK-NK|Healthy_Control / Condition, Lineage, Cell class and cell subclass

CD247 TRPA1 AUTS2 PAWR

1.68e-0417869471e99f143009b2d29cb47b96393b58b514c8cfc6
ToppCell343B-Lymphocytic-NK_cells-Proliferating_NK_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

RGS22 ZKSCAN2 PNPLA7 POLQ

1.68e-04178694c7e890cd02206c516cf1d7692ea7abc8ce746482
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

URB1 PAWR KDM7A RAI1

1.71e-041796946e965e424eebef50f0202cff75f458be395cfca1
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

CD247 HYOU1 GATA3 VPS13B

1.71e-04179694db76edd368eeca05a2a5d407c3eb2f535ade0ce3
ToppCellhuman_hepatoblastoma-Tumor_cells-T6|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

UGCG AUTS2 KDM7A RYR2

1.71e-0417969414fc8ccb6b215063d747643f47d780d2b237eb67
ToppCellmild_COVID-19-NK_CD56bright|mild_COVID-19 / disease group, cell group and cell class (v2)

CD247 GATA3 PAWR MPG

1.75e-04180694d8b418edd807a51c0b5f4018b8b478dcc65892a7
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPA1 ARID5B TMEM132B PGF

1.75e-041806948bf6e8b6b45ce42f8c5f23e7cd1752ec8b3fa2d2
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SPIRE1 ROBO1 ROBO2 RYR2

1.82e-04182694ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCell343B-Lymphocytic-NK_cells-Proliferating_NK_cell|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

RGS22 ZKSCAN2 PNPLA7 POLQ

1.82e-04182694b1e66ccd5f33b4801f1cafddf97f5fc0c6dba8d1
ToppCellHealthy_Control-Lymphoid-NK|Healthy_Control / Condition, Lineage, Cell class and cell subclass

CD247 TRPA1 AUTS2 PAWR

1.86e-04183694b41b1f32022c8632a638cf1c5523c9a24176f568
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MAP6 ROBO1 ROBO2 PAWR

1.86e-041836947c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AUTS2 ROBO1 PAWR ALPK2

1.94e-0418569434fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MAP6 RGS22 AGBL2 BAIAP3

1.94e-041856945e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCellAdult-Epithelial-ciliated_cell-D175|Adult / Lineage, Cell type, age group and donor

MAP6 RGS22 AGBL2 BAIAP3

1.94e-0418569430f4980dee6cd5959655f8d74049f3bfb5312611
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AUTS2 ROBO1 PAWR ALPK2

1.94e-041856948816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RGS22 KDM7A NFAM1 RYR2

1.98e-0418669423b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellCOVID-NK-|COVID / Condition, Cell_class and T cell subcluster

CD247 AUTS2 ZNF578 PAWR

2.06e-04188694fabdd68a9734d35e75e1f4a4bfd5c531cfc099f1
ToppCellCOVID-NK|COVID / Condition, Cell_class and T cell subcluster

CD247 AUTS2 ZNF578 PAWR

2.06e-041886940beaa671611110a11e46156f54f5202cc24967a4
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

AUTS2 ROBO1 ROBO2 PAWR

2.11e-0418969406c44746fa4f02e6e2b3b635cdf2d8dfef3754d3
ToppCell3'_v3-bone_marrow-Lymphocytic_NK-NK_CD56bright_CD16-|bone_marrow / Manually curated celltypes from each tissue

CD247 GATA3 PAWR MPG

2.11e-041896946e402fb3fc31e4cb541e3cd140d7a86c1083dbf5
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARID5B AUTS2 TMEM132B PGF

2.11e-04189694fcc3713e8200d51074f709f3360fb36efb0a639f
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RGS22 ROBO2 TMEM132B RYR2

2.11e-0418969445e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

SOWAHA ROBO1 ROBO2 RYR2

2.15e-041906946e92c78799f34b31d098854503c796edb0dc7f80
ToppCellwk_08-11-Epithelial-Airway_epithelial_progenitor-epi-stalk_early|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SMARCA5 PAWR HDC SLC12A5

2.15e-041906949f5f65869dad9a43ac94f81f9a19c72ffe5adc3c
ToppCellASK454-Epithelial-Secretory|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

URB1 POLL PAWR PNPLA7

2.19e-04191694c63c781e7e93265e591cf494cb4ce8ed797c24fb
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RGS22 ROBO2 TMEM132B RYR2

2.19e-04191694b133ee1c0e58d00ddd2e4e05b01fd04947524c18
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

AUTS2 ROBO1 ROBO2 PAWR

2.19e-041916949c0ee270209b02043393416ecc9a81ddedfbb8b6
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

AUTS2 ROBO1 ROBO2 PAWR

2.28e-041936942c15186d15545804cc262da9137ab825609d4b2c
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

AUTS2 ROBO1 ROBO2 PAWR

2.28e-04193694010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCellCOVID-19-Fibroblasts-Other_FB|COVID-19 / group, cell type (main and fine annotations)

AUTS2 ROBO1 ROBO2 RYR2

2.28e-04193694e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

AUTS2 ROBO1 ROBO2 PAWR

2.28e-041936948b77625bf3c87d39767fb391d1beaca4ab02342b
ToppCellHSPCs-Ery_prog.|World / Lineage and Cell class

GTPBP4 WAPL UGCG NOP2

2.28e-04193694484c2e0daedc6cb0d50d164add8c1658123a60f9
ToppCellnormal_Lung-Epithelial_cells-Club|normal_Lung / Location, Cell class and cell subclass

CYP2A6 CYP2A7 CYP2A13 PAWR

2.37e-04195694b46544ad5af04f4dbc2643637caa3d2d50d922ae
ToppCellmild_COVID-19-CD4+_CTL|World / disease group, cell group and cell class (v2)

CD247 ARID5B GATA3 AUTS2

2.37e-04195694980909246c30471c9f2f97c3b20b6d6d20fe574e
ToppCell-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

CD247 ROBO2 RYR2 HDC

2.37e-04195694e5b0afbea85575851cf9eb50a9ac42c67bbf3d7c
ToppCellCOPD-Lymphoid-T|COPD / Disease state, Lineage and Cell class

CD247 ARID5B GATA3 RYR2

2.42e-0419669430e53b8050d2a041f855d0e39bbd8f923c64c489
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GPR158 TMEM132B RYR2 SLC12A5

2.42e-04196694676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellCOVID-19-Fibroblasts-Intermediate_pathological_FB|COVID-19 / group, cell type (main and fine annotations)

AUTS2 ROBO1 ROBO2 RYR2

2.47e-04197694f1c8936986123a3151140c374fcd62d6705c530b
ToppCellCOVID-19-Fibroblasts|COVID-19 / group, cell type (main and fine annotations)

AUTS2 ROBO1 ROBO2 RYR2

2.47e-04197694fb847f2277609c31fffcdf49517243ce0684facf
ToppCellIPF-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

ROBO1 ROBO2 VPS13B RYR2

2.47e-04197694f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCellsevere-B_memory|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZC2HC1B ARID5B PAWR BAIAP3

2.52e-0419869488649dc642193bda5e8eff3f79c832807d5e200a
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GPR158 TMEM132B RYR2 SLC12A5

2.52e-041986946d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellSepsis-ICU-NoSEP-Lymphocyte-T/NK-Treg|ICU-NoSEP / Disease, condition lineage and cell class

CD247 UGCG ARID5B GATA3

2.52e-041986941ed4dfe5565328cb0f7ef31e6b2f67dfbdf3e2ac
ToppCellnormal_Lung-Epithelial_cells-Club|Epithelial_cells / Location, Cell class and cell subclass

CYP2A6 CYP2A7 CYP2A13 ARID5B

2.52e-04198694a9d0109ca05eb3e9c588f9677ec471dd5c092a75
ToppCellBiopsy_Control_(H.)-Epithelial-SCGB3A2+_SCGB1A1+|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

CYP2A6 CYP2A7 CYP2A13 ROBO2

2.52e-04198694a3d4b6e4259ded2193d94d2ff6d48cf67214fc35
ToppCellmLN-(1)_T_cell-(15)_Treg|mLN / shred on region, Cell_type, and subtype

CD247 UGCG ARID5B GATA3

2.52e-04198694d4885f9c59b275e4e50dfcfb51c5351bebba1769
ToppCellmLN-T_cell-Treg|mLN / Region, Cell class and subclass

CD247 UGCG ARID5B GATA3

2.52e-041986946ce9681d1287632956176239f223e71abb8de44f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GPR158 ROBO2 RYR2 SLC12A5

2.52e-041986940ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellSepsis-ICU-NoSEP-Lymphocyte-B-B_memory|ICU-NoSEP / Disease, condition lineage and cell class

ARID5B ROBO1 PAWR RYR2

2.56e-04199694acd2b87ab0d7d92515cf46ab65b766d6ade818a6
ToppCellBAL-Severe-cDC_10|Severe / Compartment, Disease Groups and Clusters

CEP350 TBC1D10A UGCG AUTS2

2.56e-0419969454bdadd04abaf8caa948b0177c037bc089ca07e6
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MAP6 RGS22 AGBL2 BAIAP3

2.61e-0420069452aef65f01b06cd98056f17977efe525aee6eb6f
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.

AUTS2 SPIRE1 ROBO2 TMEM132B

2.61e-04200694fd6b4ff4330db11c03f1eb4e06b43a162326f744
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MAP6 RGS22 AGBL2 BAIAP3

2.61e-0420069455c148238d5c80c1faa3428a917ae8075be2c145
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_CD56bright|COVID-19_Mild / Disease, condition lineage and cell class

CD247 GATA3 PAWR MPG

2.61e-04200694bb21e26a8b7cbceddb1ab5163a223a186d914da4
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.

AUTS2 SPIRE1 ROBO2 TMEM132B

2.61e-042006948795920911ee75c09a97cc948c14ad7301b27796
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)|Neuronal / cells hierarchy compared to all cells using T-Statistic

AUTS2 ROBO1 ROBO2 PAWR

2.61e-04200694347a510755374c6a66acee326565dfc447993f18
Drug2'-methoxyacetophenone

CYP2A6 CYP2A7 CYP2A13

2.44e-083673CID000068481
Drugnicotine imine

CYP2A6 CYP2A13

8.53e-062672ctd:C034629
Drugpropargyl ether

CYP2A6 CYP2A13

8.53e-062672ctd:C531209
Drugalpha-nicotyrine

CYP2A6 CYP2A13

8.53e-062672ctd:C008615
DrugHempa

CYP2A6 CYP2A13

8.53e-062672ctd:D006492
DrugN-nitrosoguvacoline

CYP2A6 CYP2A13

8.53e-062672ctd:C036676
DrugN-nitrosomethylaniline

CYP2A6 CYP2A7 CYP2A13

8.66e-0614673CID000011957
DrugN'-nitrosonornicotine

CYP2A6 CYP2A13 GATA3

1.08e-0515673ctd:C008655
Drug2-deoxyxanthosine

POLA1 POLL MPG

1.61e-0517673CID000065372
Drugirinotecan HCl; Down 200; 100uM; MCF7; HT_HG-U133A

CEP350 WAPL ARID5B PAWR ACAP2 VPS13B

1.65e-051836767498_DN
DrugHomochlorcyclizine dihydrochloride [1982-36-1]; Up 200; 10.4uM; HL60; HT_HG-U133A

UGCG ARID5B POLL KDM7A HPSE VPS13B

2.36e-051956762386_UP
Drug2-propylpentanoic acid; Up 200; 500uM; MCF7; HT_HG-U133A_EA

GTPBP4 KDM7A KIF3C ACAP2 HPSE HECA

2.43e-051966761078_UP
Drugpetasiphenol

POLA1 POLL POLQ

3.60e-0522673CID006438779
DrugNSC35549

CYP2A6 CYP2A7 CYP2A13

3.60e-0522673CID000411697
DrugNMPA

CYP2A6 CYP2A13

5.10e-054672CID000132101
DrugN'-nitrosoanatabine

CYP2A6 CYP2A13

5.10e-054672ctd:C032978
Drugpseudoisocytidine

POLA1 HPSE

5.10e-054672CID000124345
Drugaminoglutethimide

CYP2A6 CYP2A7 CYP2A13 UGCG PGF

5.25e-05137675CID000002145
Drug1,N6-ethenodeoxyadenosine

POLA1 POLL MPG

5.35e-0525673CID000105116
Drug1,2-dibromoethane

CYP2A6 CYP2A7 CYP2A13 MPG

5.74e-0571674CID000007839
DrugC14845

CYP2A6 CYP2A7 CYP2A13

6.77e-0527673CID011954064
DrugBP-9,10-oxide

CYP2A6 CYP2A7 CYP2A13

6.77e-0527673CID000037456
DrugBrn 4136738

CYP2A6 CYP2A7 CYP2A13

6.77e-0527673CID000050331
Drug7-hydroxycoumarin

CYP2A6 CYP2A7 CYP2A13 HPSE

7.11e-0575674CID005281426
Drug9-OH-BaP-4,5-oxide

CYP2A6 CYP2A7 CYP2A13

7.57e-0528673CID000115064
Drug5-nitro-1-naphthonitrile

CYP2A6 CYP2A13 GATA3

7.57e-0528673CID000031744
DrugMenthol

CYP2A6 CYP2A13 TRPA1

7.57e-0528673ctd:D008610
Drugtetrahydropalmatine

GTPBP4 SMARCA5 TMA7 MAK16 PAWR

8.33e-05151675ctd:C014215
Drugtrans-3'-hydroxycotinine

CYP2A6 CYP2A13 HPSE

8.43e-0529673CID000000414
Drug2-iodoethanol

POLA1 POLL

8.48e-055672CID000012225
DrugN-methyl-N-2-(methylsulfinyl)ethylpropionic acid amide

CYP2A6 CYP2A13

8.48e-055672ctd:C062567
Drugbenzyl selenocyanate

CYP2A6 CYP2A13

8.48e-055672ctd:C054108
Drughainanensine

POLA1 HPSE

8.48e-055672CID000127616
Drug11-H-14,15-EETA

CYP2A6 CYP2A7 CYP2A13

9.34e-0530673CID011954058
Drug19-hydroxytestosterone

CYP2A6 CYP2A7 CYP2A13

9.34e-0530673CID000150968
DrugBP-7,8-oxide

CYP2A6 CYP2A7 CYP2A13

1.14e-0432673CID000037455
Drugparaoxon

CYP2A6 CYP2A7 CYP2A13 PNPLA7 HDC

1.23e-04164675CID000009395
Drugacenaphthene-1-ol

CYP2A6 CYP2A13

1.27e-046672ctd:C023723
DrugAC1L196J

CYP2A6 CYP2A13

1.27e-046672CID000000415
Drugmenthofuran

CYP2A6 CYP2A13

1.27e-046672ctd:C054487
DrugN'-nitrosoanabasine

CYP2A6 CYP2A13

1.27e-046672ctd:C010257
DrugAC1L1HMM

CYP2A6 CYP2A7 CYP2A13 POLA1 UGCG TAF2 PGF HDC

1.33e-04516678CID000004196
Drug12(13)-EpOME

CYP2A6 CYP2A7 CYP2A13

1.37e-0434673CID000001416
DrugTCEO

CYP2A6 CYP2A7 CYP2A13

1.37e-0434673CID000028167
DrugAC1O5XSP

CYP2A6 CYP2A7 CYP2A13

1.37e-0434673CID006442739
Drugfelodipine

CYP2A6 CYP2A7 CYP2A13 TRPA1 RYR2

1.41e-04169675CID000003333
DrugAC1L1CJI

CYP2A6 CYP2A7 CYP2A13

1.49e-0435673CID000001929
Drug15-H-11,12-EETA

CYP2A6 CYP2A7 CYP2A13

1.62e-0436673CID011954042
DrugAC1L3NGJ

CYP2A6 CYP2A7 CYP2A13

1.62e-0436673CID000092121
Drughexamethylphosphoramide

CYP2A6 CYP2A7 CYP2A13

1.62e-0436673CID000012679
Drug(3S,4R,5R)-5-methylolpiperidine-2,3,4-triol

POLA1 ROBO1 HPSE

1.76e-0437673CID010197840
Drugmiglustat

UGCG PAWR

1.77e-047672ctd:C059896
Drugacenaphthene

CYP2A6 CYP2A13

1.77e-047672ctd:C042552
Drugmetyrapone

CYP2A6 CYP2A7 CYP2A13 UGCG PGF

1.85e-04179675CID000004174
Drug11,14,15-THET

CYP2A6 CYP2A7 CYP2A13

2.06e-0439673CID006439531
Drugtyrphostin AG-825; Down 200; 25.2uM; MCF7; HT_HG-U133A_EA

CEP350 WAPL UGCG ARID5B VPS13B

2.16e-041856751114_DN
DrugGangliosides

UGCG PAWR

2.36e-048672ctd:D005732
Drug11,12,15-trihydroxyeicosatrienoic acid

CYP2A6 CYP2A7 CYP2A13

2.58e-0442673CID006439610
Drugethyl iodoacetate

CYP2A6 HPSE BAIAP3

2.58e-0442673CID000012183
DrugTrifluoperazine dihydrochloride [440-17-5]; Up 200; 8.4uM; HL60; HT_HG-U133A

UGCG ARID5B GATA3 KDM7A KIF3C

2.81e-041966752389_UP
DrugEthisterone [434-03-7]; Down 200; 12.8uM; MCF7; HT_HG-U133A

AUTS2 POLL AGBL2 BAIAP3 RYR2

2.88e-041976752326_DN
Drugpolybrominated biphenyl

CYP2A6 CYP2A7 CYP2A13

2.96e-0444673CID000042948
DrugN-nitrosoguvacoline

CYP2A6 CYP2A13

3.03e-049672CID000062103
Drug3-(methylnitrosamino)propionaldehyde

CYP2A6 CYP2A13

3.03e-049672CID000098533
Drugacenaphthylene

CYP2A6 CYP2A13

3.03e-049672ctd:C042553
Drugnaphthalene-1,2-dihydrodiol

CYP2A6 CYP2A7 CYP2A13

3.16e-0445673CID000000362
Diseasemyoclonic-atonic epilepsy (implicated_via_orthology)

ROBO1 ROBO2

9.06e-057622DOID:0060475 (implicated_via_orthology)
DiseaseLiver Diseases, Parasitic

CYP2A6 ROBO2

1.55e-049622C0023897
Diseasenicotine metabolite ratio

CYP2A6 CYP2A7

2.83e-0412622EFO_0007794
Diseaseforced expiratory volume, response to bronchodilator

CYP2A6 CYP2A7 WAPL ARID5B ROBO2 TMEM132B

3.43e-04445626EFO_0004314, GO_0097366
Diseaseacute lymphoblastic leukemia

ARID5B GATA3 RYR2

3.68e-0466623EFO_0000220
DiseaseB-cell acute lymphoblastic leukemia

ARID5B GATA3

4.48e-0415622EFO_0000094
Diseasesusceptibility to childhood ear infection measurement

GATA3 AUTS2 VPS13B RAI1

4.67e-04171624EFO_0007904
Diseasevisceral adipose tissue measurement

HYOU1 GPR158 AUTS2 ROBO1 ROBO2 AGBL2

5.17e-04481626EFO_0004765
Diseaseemphysema pattern measurement

CYP2A6 VWA8

7.26e-0419622EFO_0005850
Diseasecaffeine metabolite measurement

CYP2A6 CYP2A7

7.26e-0419622EFO_0007872
Diseasesmoking behavior

CYP2A6 CYP2A7 ARID5B AUTS2 TMEM132B

7.55e-04341625EFO_0004318
DiseasePrecursor B-cell lymphoblastic leukemia

GATA3 AUTS2

8.89e-0421622C1292769
DiseaseCarcinoma, Granular Cell

CYP2A6 ROBO1 PAWR

1.89e-03116623C0205644
DiseaseAdenocarcinoma, Tubular

CYP2A6 ROBO1 PAWR

1.89e-03116623C0205645
DiseaseAdenocarcinoma, Oxyphilic

CYP2A6 ROBO1 PAWR

1.89e-03116623C0205642
DiseaseCarcinoma, Cribriform

CYP2A6 ROBO1 PAWR

1.89e-03116623C0205643
DiseaseAdenocarcinoma, Basal Cell

CYP2A6 ROBO1 PAWR

1.89e-03116623C0205641
DiseaseAdenocarcinoma

CYP2A6 ROBO1 PAWR

1.89e-03116623C0001418

Protein segments in the cluster

PeptideGeneStartEntry
DGARKVPLQPSKQMK

FBRSL1

151

Q9HCM7
GKNRQPKFEDRAKMP

CYP2A6

336

P11509
MPAKRRKTMQGEGPQ

BAG6

1046

P46379
MRLMLKKGEGRQGLP

BAIAP3

91

O94812
RVRQPGMKGNPKKPN

ALPK2

536

Q86TB3
GMKGNPKKPNANLRE

ALPK2

541

Q86TB3
KNTQGPRMPRTAKKV

GTPBP4

501

Q9BZE4
RGRPKKMNTANPERK

DOT1L

411

Q8TEK3
MGIKKPQPGQRQEKE

ACAP2

486

Q15057
MDPRGILKAFPKRQK

POLL

1

Q9UGP5
QGAMKTKVLPPRKGR

RAI1

1311

Q7Z5J4
LEVNIPRKPDGKMRG

RBM28

141

Q9NW13
KREKMRAKQNPPGPA

PAWR

26

Q96IZ0
KGENNLRPRKKGMSL

RAD17

346

O75943
MKPRPAGFVDNKLKQ

NVL

1

O15381
KIIKQPQRVGAGPMK

HDC

521

P19113
GKRPKKGMATAKQRL

KDM7A

911

Q6ZMT4
LKGQGPMVQEPLKKQ

MAP6

471

Q96JE9
HKGKMPLRGPLQRKR

MAK16

266

Q9BXY0
MPNPKNSKGGRKNKR

HECA

1

Q9UBI9
EPRKPQKSGIMKQQR

GPR158

966

Q5T848
KAQLEKRGMLGKRPR

KIF3C

391

O14782
KKMPKALRQLKPGQN

AUTS2

166

Q8WXX7
KRNKKPVQDCPRMRG

PRAMEF15

131

P0DUQ1
KIGRLKRSNMPKLGG

POLA1

661

P09884
PDVGQPRRKTAKMLK

HPSE

266

Q9Y251
EKMLRDQQGPSKKPA

PNPLA7

1211

Q6ZV29
HKMNGQNRPLIKPKR

GATA3

291

P23771
PEGEKKQKPARKRRM

HYOU1

681

Q9Y4L1
GKNRQPKFEDRAKMP

CYP2A13

336

Q16696
GRDPEMGGKPQRRKN

CD247

91

P20963
MGGKPQRRKNPQEGL

CD247

96

P20963
GKNRQPKFEDRTKMP

CYP2A7

336

P20853
LKLPPNREMKNQGSK

POLQ

2141

O75417
GEDDKMPPLRKKQRG

CEP350

1731

Q5VT06
PKQFCRRMGQKKQRP

MPG

11

P29372
ILPKNKGRMQNKKPG

AGBL2

836

Q5U5Z8
GKKVGINPKINNLMP

UGCG

116

Q16739
GKRPKEGLLQMKLPE

RYR2

1886

Q92736
NNEGGKKKPVQAPRM

SLC12A5

106

Q9H2X9
LDRRTGAKPKRKPGM

UTP18

11

Q9Y5J1
NEPMNSSGPKRKRVK

TMEM132B

1011

Q14DG7
RKGKNEVKPVQMNAP

RGS22

86

Q8NE09
MNRKKGDKGFESPRP

TAF2

11

Q6P1X5
WNKKRMRGPGKDPTR

NFAM1

186

Q8NET5
LKLMKQRRKPPGFLA

PNMA3

311

Q9UL41
KRNKKPVQDCPRMRG

PRAMEF25

131

A6NGN4
MGRKLDPTKEKRGPG

NOP2

1

P46087
DKNKPVMPARAKGPR

URB1

2016

O60287
MPKVDRKGPQIDIKG

AHNAK2

3236

Q8IVF2
RGNPGIMSPLAKKKL

ARID5B

681

Q14865
RKMWRPGEKKEPQGV

TRPA1

6

O75762
AAQKRKGKEPGMALP

ZNF578

6

Q96N58
MAPRKKTKIRGGLPA

SOWAHA

511

Q2M3V2
EEIPRMHPGRNGKKQ

PGF

186

P49763
MHPGRNGKKQQRKPL

PGF

191

P49763
RKVMVNGDIPPRLKK

SPIRE1

321

Q08AE8
KRNKKPVQDCPRMRG

PRAMEF9

131

P0DUQ2
MAKLGQKRPNFKPDI

WAPL

41

Q7Z5K2
KRNKKPVQDCPRMRG

PRAMEF11

131

O60813
RPTKKHKGGRMDQQP

ROBO2

1286

Q9HCK4
KKGARTPKVPKQGGM

ROBO1

1166

Q9Y6N7
RAQGRAQMGPKKEPT

ZC2HC1B

161

Q5TFG8
KTQKEKRKSPGQPMR

VPS13B

1521

Q7Z7G8
RQGKPMSQPRDLGKA

ZKSCAN2

721

Q63HK3
AAQKRKGKEPGMALP

ZNF611

6

Q8N823
RGPKPSTQKRKMDGA

SMARCA5

1026

O60264
GLVPMNKIPKDNKQR

VWA8

1771

A3KMH1
RKQMKGRGQLEKPPA

TBC1D10A

436

Q9BXI6
MSGREGGKKKPLKQP

TMA7

1

Q9Y2S6
NKLVMRRKGISGKGP

WASH6P

396

Q9NQA3
KGDELRFGPKPMRIK

ZMYM3

1086

Q14202