Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF567 ZNF212 MAX TRPS1 MECOM ZBTB12 ZNF25 ZNF568 ZNF284 ZNF10 ZNF677 NCOR1 ZNF23 ZNF547 ZNF33B ZNF852 ZNF408 CARF ZNF483 ZNF432 ZNF534 ZNF578 ZNF701 ZNF84 ZNF468 ZKSCAN4 ZNF319 ZNF709 ZNF682 ZNF304

1.01e-10145910830GO:0000977
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF567 ZNF212 MAX MECOM ZBTB12 ZNF568 ZNF284 ZNF677 ZNF23 ZNF547 ZNF33B ZNF852 MTOR ZNF408 CARF ZNF483 ZNF432 ZNF534 ZNF578 ZNF701 ZNF84 ZNF468 ZKSCAN4 ZNF319 ZNF709 ZNF682 ZNF304

5.41e-10127110827GO:0000987
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF212 MAX TRPS1 MECOM ZBTB12 ZNF25 ZNF568 ZNF284 ZNF10 ZNF677 ZNF23 ZNF547 ZNF33B ZNF852 ZNF408 CARF ZNF483 ZNF432 ZNF534 ZNF578 ZNF701 ZNF84 ZNF468 ZKSCAN4 ZNF319 ZNF709 ZNF682 ZNF304

1.14e-09141210828GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF567 ZNF212 MAX MECOM ZBTB12 ZNF568 ZNF284 ZNF677 ZNF23 ZNF547 ZNF33B ZNF852 ZNF408 CARF ZNF483 ZNF432 ZNF534 ZNF578 ZNF701 ZNF84 ZNF468 ZKSCAN4 ZNF319 ZNF709 ZNF682 ZNF304

1.72e-09124410826GO:0000978
GeneOntologyMolecularFunctioncytoskeleton-nuclear membrane anchor activity

SYNE1 SYNE2

2.87e-0451082GO:0140444
DomainKRAB

ZNF567 ZNF212 ZNF25 ZNF568 ZNF284 ZNF10 ZNF677 ZNF23 ZNF547 ZNF33B ZNF852 ZNF483 ZNF432 ZNF534 ZNF578 ZNF701 ZNF84 ZNF468 ZKSCAN4 ZNF709 ZNF282 ZNF682 ZNF304

4.13e-1835810623PS50805
DomainKRAB

ZNF567 ZNF212 ZNF25 ZNF568 ZNF284 ZNF10 ZNF677 ZNF23 ZNF547 ZNF33B ZNF852 ZNF483 ZNF432 ZNF534 ZNF578 ZNF701 ZNF84 ZNF468 ZKSCAN4 ZNF709 ZNF282 ZNF682 ZNF304

8.07e-1836910623SM00349
DomainKRAB

ZNF567 ZNF212 ZNF25 ZNF568 ZNF284 ZNF10 ZNF677 ZNF23 ZNF547 ZNF33B ZNF852 ZNF483 ZNF432 ZNF534 ZNF578 ZNF701 ZNF84 ZNF468 ZKSCAN4 ZNF709 ZNF282 ZNF682 ZNF304

8.57e-1837010623IPR001909
Domainzf-C2H2

ZNF567 ZNF212 TRPS1 MECOM ZBTB12 ZNF25 ZNF568 ZNF284 ZNF10 ZNF677 ZNF23 ZNF547 ZNF33B ZNF852 ZNF592 ZNF408 ZNF483 ZNF432 ZNF534 ZNF578 ZNF701 ZNF84 ZNF468 ZKSCAN4 ZNF319 ZNF709 ZNF282 ZNF682 ZNF304

1.11e-1769310629PF00096
DomainZINC_FINGER_C2H2_1

ZNF567 ZNF212 TRPS1 MECOM ZBTB12 ZNF25 ZNF568 ZNF284 ZNF10 ZNF677 ZNF23 ZNF547 ZNF33B ZNF852 ZNF592 ZNF408 ZNF483 CIZ1 ZNF432 ZNF534 ZNF578 ZNF701 ZNF84 ZNF468 ZKSCAN4 ZNF319 ZNF709 ZNF282 ZNF682 ZNF304

2.47e-1777710630PS00028
DomainZnf_C2H2-like

ZNF567 ZNF212 TRPS1 MECOM ZBTB12 ZNF25 ZNF568 ZNF284 ZNF10 ZNF677 ZNF23 ZNF547 ZNF33B ZNF852 ZNF592 ZNF408 ZNF483 CIZ1 ZNF432 ZNF534 ZNF578 ZNF701 ZNF84 ZNF468 ZKSCAN4 ZNF319 ZNF709 ZNF282 ZNF682 ZNF304

4.77e-1779610630IPR015880
DomainKRAB

ZNF567 ZNF212 ZNF25 ZNF568 ZNF284 ZNF10 ZNF677 ZNF547 ZNF33B ZNF852 ZNF483 ZNF432 ZNF534 ZNF578 ZNF701 ZNF84 ZNF468 ZKSCAN4 ZNF709 ZNF282 ZNF682 ZNF304

6.16e-1735810622PF01352
DomainZnf_C2H2

ZNF567 ZNF212 TRPS1 MECOM ZBTB12 ZNF25 ZNF568 ZNF284 ZNF10 ZNF677 ZNF23 ZNF547 ZNF33B ZNF852 ZNF592 ZNF408 ZNF483 CIZ1 ZNF432 ZNF534 ZNF578 ZNF701 ZNF84 ZNF468 ZKSCAN4 ZNF319 ZNF709 ZNF282 ZNF682 ZNF304

6.49e-1780510630IPR007087
DomainZnF_C2H2

ZNF567 ZNF212 TRPS1 MECOM ZBTB12 ZNF25 ZNF568 ZNF284 ZNF10 ZNF677 ZNF23 ZNF547 ZNF33B ZNF852 ZNF592 ZNF408 ZNF483 CIZ1 ZNF432 ZNF534 ZNF578 ZNF701 ZNF84 ZNF468 ZKSCAN4 ZNF319 ZNF709 ZNF282 ZNF682 ZNF304

7.18e-1780810630SM00355
DomainZINC_FINGER_C2H2_2

ZNF567 ZNF212 TRPS1 MECOM ZBTB12 ZNF25 ZNF568 ZNF284 ZNF10 ZNF677 ZNF23 ZNF547 ZNF33B ZNF852 ZNF592 ZNF408 ZNF483 ZNF432 ZNF534 ZNF578 ZNF701 ZNF84 ZNF468 ZKSCAN4 ZNF319 ZNF709 ZNF282 ZNF682 ZNF304

2.15e-1677510629PS50157
Domain-

ZNF567 ZNF212 MECOM ZBTB12 ZNF25 ZNF568 ZNF284 ZNF10 ZNF677 ZNF23 ZNF547 ZNF33B ZNF852 ZNF408 ZNF483 ZNF432 ZNF534 ZNF578 ZNF701 ZNF84 ZNF468 ZKSCAN4 ZNF319 ZNF709 ZNF282 ZNF682 ZNF304

6.45e-16679106273.30.160.60
Domainzf-C2H2_6

ZNF567 ZNF212 MECOM ZNF25 ZNF568 ZNF284 ZNF10 ZNF677 ZNF852 ZNF408 ZNF483 ZNF432 ZNF578 ZNF701 ZNF84 ZNF468 ZKSCAN4 ZNF709 ZNF282 ZNF682

9.38e-1631410620PF13912
DomainZnf_C2H2/integrase_DNA-bd

ZNF567 ZNF212 MECOM ZBTB12 ZNF25 ZNF568 ZNF284 ZNF10 ZNF677 ZNF23 ZNF547 ZNF33B ZNF852 ZNF408 ZNF483 ZNF432 ZNF534 ZNF578 ZNF701 ZNF84 ZNF468 ZKSCAN4 ZNF319 ZNF709 ZNF282 ZNF682 ZNF304

1.11e-1569410627IPR013087
DomainSpectrin_repeat

DSP SYNE1 SYNE2 DMD

2.09e-05291064IPR002017
DomainSpectrin/alpha-actinin

DSP SYNE1 SYNE2 DMD

3.12e-05321064IPR018159
DomainSPEC

DSP SYNE1 SYNE2 DMD

3.12e-05321064SM00150
DomainK_chnl_volt-dep_KCNQ2

KCNQ5 KCNQ2

3.19e-0521062IPR003947
DomainKASH

SYNE1 SYNE2

1.90e-0441062PF10541
DomainKASH

SYNE1 SYNE2

1.90e-0441062IPR012315
DomainKASH

SYNE1 SYNE2

1.90e-0441062PS51049
DomainKASH

SYNE1 SYNE2

1.90e-0441062SM01249
DomainActinin_actin-bd_CS

SYNE1 SYNE2 DMD

2.90e-04231063IPR001589
DomainSpectrin

SYNE1 SYNE2 DMD

2.90e-04231063PF00435
DomainACTININ_2

SYNE1 SYNE2 DMD

2.90e-04231063PS00020
DomainACTININ_1

SYNE1 SYNE2 DMD

2.90e-04231063PS00019
DomainK_chnl_volt-dep_KCNQ

KCNQ5 KCNQ2

3.16e-0451062IPR003937
DomainK_chnl_volt-dep_KCNQ_C

KCNQ5 KCNQ2

3.16e-0451062IPR013821
DomainKCNQ_channel

KCNQ5 KCNQ2

3.16e-0451062PF03520
DomainDUF3669_Znf

ZNF212 ZNF282

4.72e-0461062IPR022137
DomainDUF3669

ZNF212 ZNF282

4.72e-0461062PF12417
Domain-

URI1 PFDN1

1.12e-03910621.10.287.370
Domain-

RGPD2 GCC1

1.39e-031010621.10.220.60
DomainGrip

RGPD2 GCC1

1.70e-03111062SM00755
DomainGRIP

RGPD2 GCC1

1.70e-03111062PF01465
DomainRan_BP1

RGPD2 RANBP2

2.03e-03121062PF00638
DomainGRIP_dom

RGPD2 GCC1

2.03e-03121062IPR000237
DomainGRIP

RGPD2 GCC1

2.03e-03121062PS50913
DomainRANBD1

RGPD2 RANBP2

2.03e-03121062PS50196
DomainRanBD

RGPD2 RANBP2

2.39e-03131062SM00160
DomainRan_bind_dom

RGPD2 RANBP2

2.39e-03131062IPR000156
DomainCH

SYNE1 SYNE2 DMD

6.01e-03651063SM00033
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

ZNF567 PMS2 ZNF212 MAX DHX38 ZNF25 ZNF568 ZNF10 BMP2 ZNF677 NCOR1 ZNF23 ZNF547 ZNF33B MTOR ZNF483 TPX2 TNRC6A ZNF432 ZNF701 ZNF468 ZKSCAN4 ZNF709 ZNF282 ZNF682 ZNF304

4.94e-0813878326M734
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

RGPD2 RANBP2 ZNF212 MAX DHX38 ZNF25 ZNF284 ZNF23 ZNF852 MTOR ZNF483 TPX2 TNRC6A ZKSCAN4 ZNF709 ZNF282 ZNF682

7.83e-0510228317MM15436
Pubmed

Human transcription factor protein interaction networks.

SLK MRPS18B MAX TRPS1 MECOM PFDN1 ZNF284 NCOR1 SMC3 ZNF592 SYNE2 TPX2 TNRC6A PDCD11 HERC1 ZKSCAN4 ZNF319 CTTN ZNF709

9.61e-0814291091935140242
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

RANBP2 PMS2 URI1 DSP DHX38 TRPS1 GPRIN3 PTPN21 NCOR1 SYNE2 TNRC6A GOLIM4 DMD HERC1 ZKSCAN4

1.02e-0610491091527880917
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF567 ZNF25 ZNF33B ZNF432 ZNF701 ZNF84 ZNF468

1.75e-06181109737372979
Pubmed

Multiple genes encoding zinc finger domains are expressed in human T cells.

ZNF25 ZNF10 ZNF23 ZNF33B

2.69e-063110942288909
Pubmed

miR-30 family microRNAs regulate myogenic differentiation and provide negative feedback on the microRNA pathway.

GALNT7 TNRC6A DMD

6.45e-0612109325689854
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

RGPD2 RANBP2 MAX NCOR1 SMC3 TPX2

7.00e-06146109623892456
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

RGPD2 RANBP2 DSP TRPS1 MECOM NCOR1 ZNF592 TNRC6A ZKSCAN4

7.10e-06418109934709266
Pubmed

Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.

SYNE1 SYNE2

9.73e-062109211792814
Pubmed

Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration.

SYNE1 SYNE2

9.73e-062109224931616
Pubmed

RhoA/ROCK signalling activated by ARHGEF3 promotes muscle weakness via autophagy in dystrophic mdx mice.

ARHGEF3 DMD

9.73e-062109237311604
Pubmed

Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.

SYNE1 SYNE2

9.73e-062109222768332
Pubmed

KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3.

KCNQ5 KCNQ2

9.73e-062109235320039
Pubmed

Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.

SYNE1 SYNE2

9.73e-062109217267447
Pubmed

Nesprins: tissue-specific expression of epsilon and other short isoforms.

SYNE1 SYNE2

9.73e-062109224718612
Pubmed

Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.

SYNE1 SYNE2

9.73e-062109224586179
Pubmed

Muscle protein synthesis, mTORC1/MAPK/Hippo signaling, and capillary density are altered by blocking of myostatin and activins.

MTOR DMD

9.73e-062109223115080
Pubmed

Acute necrotizing encephalopathy-linked mutations in Nup358 impair interaction of Nup358 with TNRC6/GW182 and miRNA function.

RANBP2 TNRC6A

9.73e-062109233962210
Pubmed

Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.

SYNE1 SYNE2

9.73e-062109217761684
Pubmed

Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle.

SYNE1 SYNE2

9.73e-062109231578382
Pubmed

SOX9 promotes nasopharyngeal carcinoma cell proliferation, migration and invasion through BMP2 and mTOR signaling.

BMP2 MTOR

2.91e-053109231357026
Pubmed

Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice.

SLK DMD

2.91e-053109233259860
Pubmed

The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.

SYNE1 SYNE2

2.91e-053109216079285
Pubmed

The nuclear import of ribosomal proteins is regulated by mTOR.

RANBP2 MTOR

2.91e-053109225294810
Pubmed

A cluster of expressed zinc finger protein genes in the pericentromeric region of human chromosome 10.

ZNF25 ZNF33B

2.91e-05310921639412
Pubmed

Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.

MECOM MTOR

2.91e-053109227991928
Pubmed

Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.

SYNE1 SYNE2

2.91e-053109210878022
Pubmed

Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation.

KCNQ5 KCNQ2

2.91e-053109212890507
Pubmed

The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.

SYNE1 SYNE2

2.91e-053109212408964
Pubmed

Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.

SYNE1 SYNE2

2.91e-053109217462627
Pubmed

Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders.

RANBP2 SYNE2

2.91e-053109236930595
Pubmed

Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses.

PMS2 POLB

2.91e-053109212882965
Pubmed

Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.

SYNE1 SYNE2

2.91e-053109233472039
Pubmed

Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.

SYNE1 SYNE2

2.91e-053109225516977
Pubmed

The functional interactome landscape of the human histone deacetylase family.

NCOR1 PAXBP1 SMC3 ZNF592 SYNE2 TPX2 PDCD11

3.68e-05289109723752268
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

TNIK RANBP2 SLK CDV3 DSP DHX38 FAM114A2 NSRP1 CRACD TPX2 CIZ1 CTTN

3.78e-059341091233916271
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

SYNE1 PAXBP1 SMC3 SYNE2 DMD ZKSCAN4

3.82e-05197109620811636
Pubmed

The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification.

ZNF84 ZKSCAN4 ZNF282

4.42e-0522109331403225
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

URI1 ZNF212 MAX TRPS1 ZNF25 NCOR1 ZMAT5 ZNF592 CIZ1 ZKSCAN4 ZNF282

4.83e-058081091120412781
Pubmed

SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton.

SYNE1 SYNE2

5.82e-054109216648470
Pubmed

Long Noncoding RNA MALAT1 Regulates Cancer Glucose Metabolism by Enhancing mTOR-Mediated Translation of TCF7L2.

ABCB4 MTOR

5.82e-054109230914432
Pubmed

Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture.

SYNE1 SYNE2

5.82e-054109228716842
Pubmed

Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins.

MECOM MTOR

5.82e-054109221289308
Pubmed

LINC complexes mediate the positioning of cone photoreceptor nuclei in mouse retina.

SYNE1 SYNE2

5.82e-054109223071752
Pubmed

Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.

SYNE1 SYNE2

5.82e-054109220108321
Pubmed

Mammalian target of rapamycin is essential for cardiomyocyte survival and heart development in mice.

MTOR DMD

5.82e-054109225139234
Pubmed

Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton.

SYNE1 SYNE2

5.82e-054109219596800
Pubmed

Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p.

ZNF25 ZNF33B

5.82e-054109212566394
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

RANBP2 ATP13A1 MRPS18B SYNE1 DHX38 TRPS1 CRACD PAXBP1 ZNF592 TPX2 TNRC6A CIZ1 GOLIM4 PDCD11 EDRF1

6.82e-0514971091531527615
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

RGPD2 RANBP2 MRPS18B SYNE1 DHX38 TRPS1 PFDN1 CWC22 PHKA2 PAXBP1 SMC3 TPX2 CIZ1

6.84e-0511551091320360068
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

RANBP2 DSP MYO9B MAX TRPS1 MECOM PHKA2 CRACD NCOR1 SMC3 TPX2

8.17e-058571091125609649
Pubmed

LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.

SYNE1 SYNE2

9.67e-055109222632968
Pubmed

Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution.

ZNF25 ZNF33B

9.67e-05510928464732
Pubmed

Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX.

PMS2 MAX

9.67e-055109212584560
Pubmed

The contribution of Kv7 channels to pregnant mouse and human myometrial contractility.

KCNQ5 KCNQ2

9.67e-055109220132415
Pubmed

Dual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinase.

KCNQ5 KCNQ2

9.67e-055109215304482
Pubmed

Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells.

ABCB4 CTTN

9.67e-055109215159385
Pubmed

Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness.

SYNE1 SYNE2

9.67e-055109218396275
Pubmed

Hypoxia induces BMP-2 expression via ILK, Akt, mTOR, and HIF-1 pathways in osteoblasts.

BMP2 MTOR

9.67e-055109220232298
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

DSP SYNE1 TPX2 DMD HERC1 CTTN

9.89e-05234109636243803
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

DSP DYNC2H1 MYO9B MAX DHX38 MECOM PFDN1 NCOR1 TNRC6A

1.01e-04588109938580884
Pubmed

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.

PMS2 SMC3 TPX2 GCC1 HERC1

1.10e-04149109525184681
Pubmed

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.

TNIK SYNE1 ZNF10 SMC3 DMD

1.17e-04151109517043677
Pubmed

Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.

SYNE1 SYNE2

1.45e-046109233058875
Pubmed

TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.

SYNE1 SYNE2

1.45e-046109218827015
Pubmed

The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels.

KCNQ5 KCNQ2

1.45e-046109212032157
Pubmed

Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1.

VAC14 MTOR

1.45e-046109222696681
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

RANBP2 SLK NRDC DSP DYNC2H1 ATP13A1 SYNE1 DHX38 CWC22 PAXBP1 SMC3 MTOR PDCD11 CTTN

1.49e-0414251091430948266
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

PMS2 NRDC ZNF212 DHX38 GALNT7 ANKRD6 ZNF568 FEM1B TAOK3 PAXBP1 ARHGEF3 HERC1

1.54e-0410841091211544199
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DYNC2H1 ATP13A1 PPFIA4 DHX38 GPRIN3 ANKRD6 RALGAPA2 TRIM66

1.68e-04493109815368895
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

PMS2 DSP ATP13A1 SYNE1 ADAM9 TRPS1 ANKRD6 TRIM66 ZNF592 KCNN1 KCNQ2 ZNF84 CTTN

1.97e-0412851091335914814
Pubmed

Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.

PMS2 SLK POLB MECOM ZNF592 TPX2 CIZ1 ZKSCAN4 EDRF1

2.02e-04645109925281560
Pubmed

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

RGPD2 RANBP2

2.02e-04710929037092
Pubmed

Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

RGPD2 RANBP2

2.02e-047109211353387
Pubmed

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

RGPD2 RANBP2

2.02e-047109230944974
Pubmed

Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.

RGPD2 RANBP2

2.02e-047109238838144
Pubmed

Retina-specifically expressed novel subtypes of bovine cyclophilin.

RGPD2 RANBP2

2.02e-04710927559465
Pubmed

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

RGPD2 RANBP2

2.02e-047109217372272
Pubmed

Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.

RGPD2 RANBP2

2.02e-047109238657106
Pubmed

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.

RGPD2 RANBP2

2.02e-047109221205196
Pubmed

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.

RGPD2 RANBP2

2.02e-047109218949001
Pubmed

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

RGPD2 RANBP2

2.02e-047109225187515
Pubmed

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

RGPD2 RANBP2

2.02e-04710928603673
Pubmed

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

RGPD2 RANBP2

2.02e-047109226632511
Pubmed

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

RGPD2 RANBP2

2.02e-047109224403063
Pubmed

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

RGPD2 RANBP2

2.02e-047109223818861
Pubmed

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

RGPD2 RANBP2

2.02e-047109223536549
Pubmed

Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.

RGPD2 RANBP2

2.02e-047109212191015
Pubmed

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

RGPD2 RANBP2

2.02e-047109222821000
Pubmed

Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.

RGPD2 RANBP2

2.02e-047109220682751
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

RANBP2 DSP CWC22 NSRP1 NCOR1 PAXBP1 TPX2 CIZ1 PDCD11 ZKSCAN4 CTTN

2.08e-049541091136373674
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

TNIK SLK NRDC DSP ADAM9 GALNT7 NCOR1 NAA35 SMC3 SYNE2 TPX2 GOLIM4 PDCD11

2.15e-0412971091333545068
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

TNIK DYNC2H1 ATP13A1 MRPS18B SYNE1 SNAP47 NSRP1 NAA35 PAXBP1 SYNE2 CIZ1 PDCD11 AKAP11 EDRF1

2.31e-0414871091433957083
Pubmed

Mutation of ARHGAP9 in patients with coronary spastic angina.

MYO9B PLEKHG2 ARHGEF3

2.33e-0438109319911011
Pubmed

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.

RGPD2 RANBP2

2.69e-048109221670213
Pubmed

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

RGPD2 RANBP2

2.69e-048109227412403
Pubmed

Mice lacking Ran binding protein 1 are viable and show male infertility.

RGPD2 RANBP2

2.69e-048109221310149
Pubmed

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.

RGPD2 RANBP2

2.69e-048109222262462
Pubmed

Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.

RGPD2 RANBP2

2.69e-048109228745977
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

DSP MECOM NCOR1 ZNF592 TNRC6A

2.94e-04184109532908313
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TNIK SLK SYNE1 ADAM9 FEM1B CRACD ZNF319

3.06e-04407109712693553
InteractionTRIM28 interactions

TNIK ZNF567 RANBP2 SLK URI1 MRPS18B DHX38 ZNF25 ZNF284 ZNF10 NCOR1 ZNF33B SMC3 MTOR ZNF483 ZNF432 PDCD11 ZNF701 ZNF84 ZNF468 ZNF682 ZNF304

1.11e-05147410922int:TRIM28
InteractionERMAP interactions

NRDC MECOM CWC22 AKAP11

1.50e-05281094int:ERMAP
InteractionDISC1 interactions

TNIK ATP13A1 PPFIA4 SYNE1 DHX38 ITGA1 NSRP1 KCNQ5 SMC3 GCC1 DMD

2.11e-0542910911int:DISC1
Cytoband19q13.41

ZNF432 ZNF534 ZNF578 ZNF701 ZNF468

1.26e-0678109519q13.41
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZNF567 PLEKHG2 ZNF568 ZNF284 ZNF677 ZNF547 ZNF432 ZNF534 ZNF578 ZNF701 ZNF468 ZNF304

2.76e-05119210912chr19q13
Cytoband10q24.33

SLK PDCD11

3.63e-0412109210q24.33
Cytoband3q26.2

MECOM GOLIM4

1.89e-032710923q26.2
Cytoband15q22

FEM1B HERC1

2.17e-0329109215q22
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF567 ZNF212 TRPS1 MECOM ZBTB12 ZNF25 ZNF568 ZNF284 ZNF10 ZNF677 ZNF23 ZNF547 ZNF33B ZNF852 ZNF592 ZNF408 ZNF483 ZNF432 ZNF534 ZNF578 ZNF701 ZNF84 ZNF468 ZKSCAN4 ZNF319 ZNF709 ZNF282 ZNF682 ZNF304

1.55e-20718812928
GeneFamilySpectrin repeat containing nuclear envelope family

SYNE1 SYNE2

1.18e-0448121252
GeneFamilyPrefoldin subunits

URI1 PFDN1

5.45e-048812956
GeneFamilyZinc fingers C2H2-type|PR/SET domain family

MECOM ZNF408

2.58e-03178121197
CoexpressionCHIBA_RESPONSE_TO_TSA_DN

DSP ADAM9 ITGA1 DMD

1.60e-06211094M12459
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000

RANBP2 CDV3 DYNC2H1 MECOM ZBTB12 ANKRD6 CWC22 NSRP1 CRACD NCOR1 VAC14 ZNF23 CCNYL1 SMC3 SYNE2 TPX2 DMD PHF21B

1.58e-0698910518Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000_k-means-cluster#2

RANBP2 MECOM ZBTB12 NSRP1 NCOR1 ZNF23 CCNYL1 SMC3 SYNE2 TPX2

3.32e-0631110510Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000_K2
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_500_k-means-cluster#5

RANBP2 ZBTB12 ZNF23 SMC3 SYNE2 TPX2 DMD PHF21B

2.02e-052321058Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_500_K5
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_1000_k-means-cluster#2

RANBP2 ZBTB12 ZNF23 TAOK3 SMC3 SYNE2 TPX2 DMD PHF21B

3.67e-053281059Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_1000_K2
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500_k-means-cluster#3

DYNC2H1 ZBTB12 NSRP1 ZNF23 SMC3 SYNE2 TPX2

4.78e-051921057Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500_K3
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_2500_k-means-cluster#5

RANBP2 DYNC2H1 ZBTB12 ANKRD6 NSRP1 CRACD NCOR1 ZNF23 SMC3 SYNE2 TPX2 GOLIM4 DMD CTTN

5.97e-0583110514Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_2500_K5
CoexpressionAtlasFacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_1000

SLK CDV3 URI1 NWD1 SYNE1 TRPS1 MECOM PLEKHG2 CWC22 NSRP1 TMEM132C ZNF23 PAXBP1 SMC3 SYNE2

1.04e-0498910515Facebase_RNAseq_e10.5_Maxillary Arch_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_500

RANBP2 MECOM ZBTB12 CWC22 ZNF23 SMC3 SYNE2 TPX2 DMD PHF21B

1.67e-0449310510Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_500
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

TNIK RANBP2 GPRIN3 ZNF10 SYNE2 HERC1 PRKY

4.48e-07192108747646d7e4990be85072987f92bf18d52f8da752e
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TNIK URI1 GPRIN3 ITGA1 PAXBP1 LGR6 HERC1

4.97e-0719510874b9663509cc5e3f409f6d0d37640cb301a827d98
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PPFIA4 SYNE1 ITGA1 PLEKHG2 TMEM132C KCNQ5

3.71e-061701086876b84740e15399bfff2b9c7f0b80fd759bbdb3f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PPFIA4 SYNE1 ITGA1 PLEKHG2 TMEM132C KCNQ5

3.71e-0617010861f8738acf439d893880db7e1fdc9b3615ca00c39
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

RANBP2 SYNE1 GPRIN3 SYNE2 HERC1 PRKY

3.83e-0617110862e9a20f8980b78325c52065a9c14ab3656267c05
ToppCellNS-critical-LOC-Lymphoid-NK|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

TNIK SYNE1 GPRIN3 ITGA1 SYNE2 ARHGEF3

3.83e-061711086adda76991d9b150bb8ccf3989b7cbbf41843cf0b
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RANBP2 ZNF25 IGSF10 PAXBP1 GOLIM4 DMD

4.52e-061761086749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellsevere-CD8+_T_naive|severe / disease stage, cell group and cell class

TMEM116 ZNF677 ZNF852 ZNF432 ZNF84 FCHSD1

5.15e-06180108694fe530367b170777f4051a4034cff06d80dbb83
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDV3 DSP NCOR1 SYNE2 GOLIM4 AKAP11

7.23e-06191108660c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDV3 DSP NCOR1 SYNE2 GOLIM4 AKAP11

7.23e-06191108609db184cb90fe282a14474d7217068c58092c6f8
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDV3 DSP NCOR1 SYNE2 GOLIM4 AKAP11

7.23e-061911086973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TNIK RGPD2 GPRIN3 SNAP47 LGR6

3.69e-051541085ec920cae12ea1d14b6c973f6e903f895f80e3c50
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

RANBP2 GPRIN3 ZNF10 SYNE2 HERC1

3.93e-0515610851545169694f686d28648a68b552c2ae606599d66
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RANBP2 DYNC2H1 SYNE1 ZBTB12 CCNYL1

4.17e-05158108512661763d1c309106801cb710c04cd2b62d16cba
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial-epithelial_cell_of_thymus|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RANBP2 DYNC2H1 SYNE1 ZBTB12 CCNYL1

4.17e-051581085e7db50d6dfaf7280a73a0d5b5aa4f43ea2762d72
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial-TECs|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RANBP2 DYNC2H1 SYNE1 ZBTB12 CCNYL1

4.17e-0515810850792c39e6fc0745095af7812de2d50949540d60f
ToppCellfacs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DYNC2H1 ANKRD6 MYO3B ANGPTL4 AKAP11

5.91e-051701085d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RANBP2 SYNE1 ITGA1 SMC3 SYNE2

7.35e-05178108501dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8|Liver / Manually curated celltypes from each tissue

RANBP2 GPRIN3 ZNF10 SYNE2 HERC1

7.95e-051811085f2315414e714ac86211546a935660c4be6e85f1b
ToppCelldroplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNIK MECOM ITGA1 RALGAPA2 BMP2

8.37e-051831085709a486154b3157427deb3b8886b63ac39ea42dd
ToppCelldroplet-Liver-nan-3m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNIK MECOM ITGA1 RALGAPA2 BMP2

8.37e-051831085dc06f19f6f80f4c7f13f1f990c1fe0f91ba64ea7
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PPFIA4 CRACD GOLIM4 ARHGEF3 PHF21B

8.37e-0518310853c516fe5083f02bad1f464ed284010b4131a833c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PPFIA4 CRACD GOLIM4 ARHGEF3 PHF21B

8.37e-0518310859c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA1 PLEKHG2 CRACD LGR6 DMD

8.37e-051831085667717366cb181b8a04a347e64f0f5a4dfc6ee7f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PPFIA4 CRACD GOLIM4 ARHGEF3 PHF21B

8.59e-0518410857294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic-effector_CD4-positive,_alpha-beta_T_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TNIK RANBP2 SYNE1 GPRIN3 SYNE2

9.27e-051871085e61c1755531469dd3850c9740474b5ad4e0499c1
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

RANBP2 ITGA1 ZNF10 SYNE2 HERC1

9.50e-051881085ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYNE1 ZBTB12 SYNE2 LGR6 ARHGEF3

9.74e-051891085bed43041e6f8ba19787150a6aaa492f2656135d9
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SYNE1 ITGA1 TMEM132C LGR6 DMD

9.74e-0518910857ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TNIK SPATA6 DYNC2H1 TMEM132C IGSF10

9.74e-051891085203c80030df08ae112f9ae4043709f455d87ce89
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYNE1 GPRIN3 SYNE2 LGR6 ARHGEF3

9.99e-051901085d153a0bdedcd6865e6ee19575234a78b5d859ff1
ToppCellPCW_13-14|World / Celltypes from embryonic and fetal-stage human lung

TNIK SPATA6 RALGAPA2 TMEM132C NCOR1

9.99e-05190108562a3ec1ae0829602b0569cc051210551644f1d46
ToppCellCOPD-Lymphoid-T_Regulatory|Lymphoid / Disease state, Lineage and Cell class

TNIK TRPS1 GPRIN3 SYNE2 ZNF282

1.02e-0419110853ae18bc4e3dff49b5d5958da8ebc3f747274b69c
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SYNE1 ITGA1 TMEM132C LGR6 DMD

1.02e-04191108508042952431ca1a6fd7dfc13f36eb28643979598
ToppCellRA-09._Endothelium_I|World / Chamber and Cluster_Paper

SYNE1 MECOM ITGA1 RALGAPA2 SYNE2

1.02e-041911085c8a0c2af119bc34a8f694a7d30642f28002c84b9
ToppCellRA-09._Endothelium_I|RA / Chamber and Cluster_Paper

SYNE1 MECOM ITGA1 RALGAPA2 SYNE2

1.05e-0419210858a1b1c3e83a68ad74f8f4eb00455c9e41aa57cfc
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TNIK SYNE1 GPRIN3 SYNE2 HERC1

1.07e-0419310859337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellRV-10._Endothelium_II|World / Chamber and Cluster_Paper

MECOM ITGA1 RALGAPA2 TMEM132C SYNE2

1.07e-0419310852531266bc57339d4e2b22a88817008e32b8c1598
ToppCellLA-09._Endothelium_I|World / Chamber and Cluster_Paper

SYNE1 MECOM ITGA1 RALGAPA2 SYNE2

1.13e-041951085fc95457a298b5d0dab687d9ee7e225a7f7b9a0d4
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TNIK SYNE1 SYNE2 LGR6 ARHGEF3

1.13e-04195108514a6466524c22920daa622fbc710daf1defb46c3
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TNIK GPRIN3 ITGA1 PAXBP1 ARHGEF3

1.16e-041961085c9fb81a0578db6d278b8582d7b3add6c407e6dcf
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TNIK SYNE1 GPRIN3 SYNE2 HERC1

1.18e-04197108557ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellmild-low-quality_cells|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TNIK SYNE1 GPRIN3 SYNE2 ZNF682

1.18e-041971085e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCellLA-09._Endothelium_I|LA / Chamber and Cluster_Paper

SYNE1 MECOM ITGA1 RALGAPA2 SYNE2

1.18e-041971085ab6d1ab586a188597a39854ef980b8955ebcc645
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-IPC_like|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

SYNE2 KCNN1 KCNQ2 ARHGEF3 PHF21B

1.21e-0419810856d12ecaa9532c134d9c4562534dcb59a6420b4d3
ToppCellT_cells|World / Immune cells in Kidney/Urine in Lupus Nephritis

TNIK SYNE1 GPRIN3 SYNE2 ARHGEF3

1.21e-0419810851ca6cd8e75891fdfaddbb4a7342eec9ca4d11e5d
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-IPC_like-IPs_and_early_cortical_neurons|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

SYNE2 KCNN1 KCNQ2 ARHGEF3 PHF21B

1.21e-0419810857943e4f67c3d6efb5c8b00aa0ff3cfe7be10c48d
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TNIK SYNE1 GPRIN3 SYNE2 HERC1

1.24e-041991085f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellSepsis-Leuk-UTI-Lymphocyte-T/NK-dn_T|Leuk-UTI / Disease, condition lineage and cell class

URI1 ZNF852 CARF TPX2 ZNF282

1.24e-041991085aa4d8ce8994e5032a33d5cc68c482882147cdc3b
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

TRPS1 MECOM TNRC6A DMD HERC1

1.24e-04199108594b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

GALNT7 NSRP1 NCOR1 SMC3 SYNE2

1.24e-041991085c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

DYNC2H1 SYNE1 ADAM9 TMEM132C IGSF10

1.24e-04199108530d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCell(01)_IL1RL1+-(2)_GFP_FOXI1|(01)_IL1RL1+ / shred by cell type by condition

GALNT7 NSRP1 SMC3 SYNE2 GOLIM4

1.24e-041991085a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

DYNC2H1 SYNE1 ADAM9 TMEM132C IGSF10

1.27e-0420010859b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-SULF1--L4-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

TMEM132C CRACD MYO3B GOLIM4 PHF21B

1.27e-0420010854a426ef88376d8bb2b9dc50aa06e7b9fc50ecc9c
ToppCellSepsis-Int-URO-Lymphocyte-T/NK-gd_T|Int-URO / Disease, condition lineage and cell class

SYNE1 TMEM132C SYNE2 ZNF578 ARHGEF3

1.27e-042001085d382ee690e370886009eff42d14952d44a6d4d18
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-SULF1|Neuronal / cells hierarchy compared to all cells using T-Statistic

TMEM132C CRACD MYO3B GOLIM4 PHF21B

1.27e-042001085fbeee1c16ac0a7fe28d90491c8b079f21ce80bdc
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-SULF1-|Neuronal / cells hierarchy compared to all cells using T-Statistic

TMEM132C CRACD MYO3B GOLIM4 PHF21B

1.27e-042001085c6eda342ea0cb37d71d89dbb8d11e819e0745172
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

RANBP2 SLK NRDC PAXBP1 SYNE2 GOLIM4

3.75e-0750626GAVISH_3CA_MALIGNANT_METAPROGRAM_4_CHROMATIN
DiseaseAutosomal dominant Emery-Dreifuss muscular dystrophy

SYNE1 SYNE2

7.63e-0541062cv:CN293514
DiseaseMammary Carcinoma, Human

DYNC2H1 SYNE1 MECOM BMP2 NCOR1 MTOR ANGPTL4 ZNF432 LGR6

1.19e-045251069C4704874
DiseaseMammary Neoplasms, Human

DYNC2H1 SYNE1 MECOM BMP2 NCOR1 MTOR ANGPTL4 ZNF432 LGR6

1.19e-045251069C1257931
DiseaseMammary Neoplasms

DYNC2H1 SYNE1 MECOM BMP2 NCOR1 MTOR ANGPTL4 ZNF432 LGR6

1.22e-045271069C1458155
DiseaseAutosomal Recessive Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

1.27e-0451062C1450051
DiseaseAutosomal Dominant Emery-Dreifuss Muscular Dystrophy (disorder)

SYNE1 SYNE2

1.27e-0451062C0410190
DiseaseMalignant neoplasm of breast

DYNC2H1 SYNE1 MECOM ZNF25 BMP2 NCOR1 MTOR SYNE2 ANGPTL4 ZNF432 GOLIM4 LGR6 DMD

1.27e-04107410613C0006142
DiseaseBreast Carcinoma

DYNC2H1 SYNE1 MECOM BMP2 NCOR1 MTOR ANGPTL4 ZNF432 LGR6

1.43e-045381069C0678222
DiseaseEmery-Dreifuss muscular dystrophy

SYNE1 SYNE2

1.90e-0461062cv:C0410189
Diseasestearoyl sphingomyelin (d18:1/18:0) measurement

SYNE2 ANGPTL4

1.90e-0461062EFO_0800611
DiseaseMuscular Dystrophy, Emery-Dreifuss

SYNE1 SYNE2

1.90e-0461062C0410189
DiseaseColorectal Carcinoma

PMS2 SYNE1 ABCB4 BMP2 KCNQ5 TPX2 ZNF432 LGR6 DMD EDRF1

2.23e-0470210610C0009402
DiseaseX-Linked Emery-Dreifuss Muscular Dystrophy

SYNE1 SYNE2

2.65e-0471062C0751337
Diseaselong QT syndrome (implicated_via_orthology)

KCNQ5 KCNQ2

5.65e-04101062DOID:2843 (implicated_via_orthology)
DiseaseEmery-Dreifuss muscular dystrophy (implicated_via_orthology)

SYNE1 SYNE2

8.24e-04121062DOID:11726 (implicated_via_orthology)
Diseasedevelopmental and epileptic encephalopathy (implicated_via_orthology)

KCNQ5 KCNQ2

9.72e-04131062DOID:0112202 (implicated_via_orthology)
Diseasenon-high density lipoprotein cholesterol measurement

NRDC TRPS1 PFDN1 ITGA1 ABCB4 ZMAT5 SYNE2 ANGPTL4 ARL14

1.09e-037131069EFO_0005689
DiseaseMyopia

BMP2 KCNQ5

1.30e-03151062C0027092
Diseaseovarian neoplasm

PMS2 URI1 MECOM MTOR

1.41e-031341064C0919267
DiseaseMalignant neoplasm of ovary

PMS2 URI1 MECOM MTOR

1.53e-031371064C1140680
DiseaseMalignant neoplasm of endometrium

PMS2 MAX

1.88e-03181062C0007103
DiseaseMyeloid Leukemia

MECOM SMC3

1.88e-03181062C0023470
DiseaseLeukemia, Monocytic, Chronic

MECOM SMC3

1.88e-03181062C0023466
DiseaseCarcinoma in situ of endometrium

PMS2 MAX

1.88e-03181062C0346191
Diseasegastric ulcer

MYO9B MECOM

2.57e-03211062EFO_0009454
Diseasewhite matter microstructure measurement

TNIK SLK MECOM PFDN1 NSRP1 CARF

2.89e-033901066EFO_0005674
DiseaseColorectal Neoplasms

SYNE1 ABCB4 BMP2 ZNF432 LGR6

3.30e-032771065C0009404
Diseasechronic obstructive pulmonary disease

DSP MECOM ITGA1 NSRP1 KCNQ5 ZKSCAN4 ZNF319 CTTN

3.42e-036881068EFO_0000341

Protein segments in the cluster

PeptideGeneStartEntry
DHKKQDHRVQDFLQR

ARHGEF3

226

Q9NR81
HKVAQQQRHLEKQHL

ANGPTL4

121

Q9BY76
KELGHLTHQQAREVK

ATP13A1

691

Q9HD20
EHHQEADKKRQSKRN

AKAP11

1416

Q9UKA4
QRQFEHILKNEHIKN

ARL14

101

Q8N4G2
DHNKQLESQLHRLRQ

DMD

3581

P11532
AHLEEKQGVSKRHVR

BMP2

231

P12643
QTDVREKRKSNHLNH

CCNYL1

96

Q8N7R7
RHKNRGRDEVSKNQA

CDV3

221

Q9UKY7
QQHSDTEKHEGEKRQ

ANKRD6

481

Q9Y2G4
RLGQQLRHDDSKQHT

NWD1

321

Q149M9
QHEINTLRAQEKHGL

RANBP2

556

P49792
RGHEKREDQHQQKQS

NSRP1

311

Q9H0G5
QRHVRNIHNKEKPFK

MECOM

956

Q03112
QTNLDRHLKKHENGN

MECOM

981

Q03112
RKNHTHQQDIDDLKR

MAX

76

P61244
HRCQKLEEIGLQHNR

LGR6

371

Q9HBX8
QVGDEHLRKQHRVLA

EDRF1

1041

Q3B7T1
SQRQIEEQHHHKGRL

PPFIA4

466

O75335
KEIAAKLNIHRVHGQ

KIAA1109

1816

Q2LD37
RKHQRKFLQAIHQAQ

KCNN1

421

Q92952
EQHRQKHFEKRRNPA

KCNQ5

356

Q9NR82
ESQHQITEGKRKNHE

HERC1

2476

Q15751
DRKQKERRQEHGHQE

CWC22

741

Q9HCG8
DIKNHIHEVQKSLRN

CARF

471

Q8N187
LHLRQKGNRNTHKDL

FEM1B

371

Q9UK73
DIQIEQLNRTKKHAH

PFDN1

31

O60925
QEQHRQKHFEKRRNP

KCNQ2

321

O43526
QGDAQHKQHQRLREV

MS4A10

231

Q96PG2
HKQHQRLREVKQVAP

MS4A10

236

Q96PG2
HKTNRQQHEKHLQSR

PAXBP1

406

Q9Y5B6
DGESHDNHRLKKVIQ

ITGA1

281

P56199
QPIQENKGHVKREHE

RALGAPA2

796

Q2PPJ7
RVKEHGTHQQLLAQK

ABCB4

1256

P21439
KQLNRGLVHAERQSH

PTPN21

456

Q16825
RKAHQDIHTQLQDVK

GOLIM4

186

O00461
KIQNHGHRVLQRLEQ

FCHSD1

341

Q86WN1
EQAHRGNKQISKERA

DYNC2H1

181

Q8NCM8
RKQKHRLEVEVHQLQ

GCC1

671

Q96CN9
NNHNPKGRLRNQHKV

IGSF10

1211

Q6WRI0
RRINKAKNEQEHHAG

GALNT7

86

Q86SF2
SKKHRRLAQDPQHEQ

CRACD

171

Q6ZU35
KQAHLRNEHFQKAIE

DSP

1676

P15924
QAEGKEHIIHLERNK

ADAM9

71

Q13443
ENKIESHRHELQGQK

FAM114A2

486

Q9NRY5
NHLQRQIREHEKLIK

GPRIN3

711

Q6ZVF9
RKNEDKLNHHQRIGL

POLB

126

P06746
AENNHIKDLLRKHGV

PHKA2

446

P46019
HQNQARDEKKKLRHA

MTOR

1806

P42345
EKVQNKHLEVRHQRS

VAC14

756

Q08AM6
KNQAERKADNHTAHR

TEX55

36

Q96M34
LDHFRRKGINQHVQN

SMC3

516

Q9UQE7
KQAVGLVEHRKEHVR

URI1

111

O94763
LHDNKIIHRDLKAGN

SLK

146

Q9H2G2
KRLEDTARVLHHQGQ

SNAP47

176

Q5SQN1
QEKRLKQQHRIGDQA

SYNE1

7041

Q8NF91
EIKNHASDRRQKGQH

TMEM132C

816

Q8N3T6
NLHQHLKQEQEGVER

SYNE2

4066

Q8WXH0
QHEINTLRAQEKHGL

RGPD2

556

P0DJD1
EHLDHRLREKVKQQN

ODAD3

151

A5D8V7
RRHNLDNLLQQHKQK

NCOR1

671

O75376
IRRKQEQHVHNEKSV

PRKY

86

O43930
RISKHKENLQHTQAE

TAOK3

581

Q9H2K8
KNLSQDQEHGRKAHK

SEMG2

271

Q02383
HQGRIKNAREAHSQI

ARNTL

66

O00327
DLIQHRRTQDHKIAK

CIZ1

666

Q9ULV3
KLRKGSEHQAIVQHL

PDCD11

921

Q14690
NLIVHQRTHKGENIE

ZNF567

631

Q8N184
HIQRGLHRNNAQVEK

TRPS1

1261

Q9UHF7
QHKRLTQAIQKARDH

MRPS18B

146

Q9Y676
QHKVIHRDIKGQNVL

TNIK

146

Q9UKE5
RRHLKEQHGKTTAEN

ZBTB12

431

Q9Y330
RHDQRHAGNKPIKDQ

ZNF578

141

Q96N58
QKSNLERHKIIHTGE

ZNF578

466

Q96N58
KSQLTQHQRIHIGEK

ZNF33B

621

Q06732
RKENLITHQKIHTGE

ZNF568

261

Q3ZCX4
QRQNLLEHEKIHTGE

ZNF568

541

Q3ZCX4
IQIHGHNRARQRDKL

NAA35

436

Q5VZE5
RHQNGDLKKQLHERQ

PHF21B

16

Q96EK2
HKLRENVFQEHQTLK

CTTN

56

Q14247
NSLRKHIRNNHDTVK

ZNF592

1026

Q92610
QRDLKEHQVVHSGAR

ZNF408

421

Q9H9D4
SHLNEHKRVQRGEKS

ZNF682

466

O95780
QHKFHQLKQEARRDA

TMEM116

196

Q8NCL8
NSNLQRHRKIHTGEK

ZNF534

491

Q76KX8
LKHEPRKNNIDTHAR

NRDC

351

O43847
REQHLHKQKQKRISA

DHX38

351

Q92620
NDQQRRQLGKSHLHR

RHPN2P1

316

A8MT19
NIEDHKNQGRKLRSH

ZNF709

51

Q8N972
AKRIKQLHHEAQQSE

PMS2

626

P54278
KSNLINHQRIHTGEK

ZNF84

331

P51523
QFANLTRHQKIHIEK

ZNF677

526

Q86XU0
KNDLIKHQRIHVGEE

ZNF10

501

P21506
REHLNKHQGVHAREQ

ZNF319

526

Q9P2F9
NRNLIDHQRTHTGEK

ZNF852

311

Q6ZMS4
SKNEDLIRHQKIHTR

ZNF25

156

P17030
HLLRHQRIHGDKNVQ

ZKSCAN4

446

Q969J2
LHQHQKEQIREKLSR

ZNF547

121

Q8IVP9
KRNLIVHQRNHTGEK

ZNF432

301

O94892
DRSFQDNLHNRKKHL

ZMAT5

11

Q9UDW3
LQHQKIHQRERGGLA

ZNF212

471

Q9UDV6
EHQKRQKIHLGDRSQ

ZNF483

376

Q8TF39
KHRHLLQAKNQEEKR

PLEKHG2

386

Q9H7P9
RKDTLVQHQKIHTGE

ZNF304

486

Q9HCX3
RHDQRHAGNKPIKNE

ZNF701

191

Q9NV72
NTKLIQHQRIHTGEK

ZNF23

376

P17027
RIFEVKHQHRKVENQ

TRIM66

136

O15016
HDQRHAGNKRIKDQL

ZNF468

126

Q5VIY5
DRVKNVLKSHQAHQR

SPATA6

381

Q9NWH7
RHQEHKQLLKRGQHF

TNRC6A

141

Q8NDV7
KEHLQNHQRLHTGER

ZNF282

586

Q9UDV7
NSQLREHQRIHTGEK

ZNF284

271

Q2VY69
HFRTDERIKQHPKNQ

TPX2

261

Q9ULW0
HLHNNRIIHRDVKGN

MYO3B

146

Q8WXR4
RRQRGLEHVKFQNKH

MYO9B

1151

Q13459