Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	regulation of canonical Wnt signaling pathway	USP8 LRRK1 CTNND1 CSNK1G2 SHISA6 CSNK1G1	3.42e-05	285	45	6	GO:0060828
GeneOntologyBiologicalProcess	lens development in camera-type eye	TMOD1 CRYGB CRYGD NECTIN3	7.47e-05	103	45	4	GO:0002088
GeneOntologyBiologicalProcess	canonical Wnt signaling pathway	USP8 LRRK1 CTNND1 CSNK1G2 SHISA6 CSNK1G1	9.70e-05	344	45	6	GO:0060070
GeneOntologyBiologicalProcess	lens fiber cell differentiation	TMOD1 CRYGB CRYGD	1.21e-04	44	45	3	GO:0070306
GeneOntologyBiologicalProcess	positive regulation of canonical Wnt signaling pathway	USP8 LRRK1 CSNK1G2 CSNK1G1	1.39e-04	121	45	4	GO:0090263
GeneOntologyBiologicalProcess	regulation of Wnt signaling pathway	USP8 LRRK1 CTNND1 CSNK1G2 SHISA6 CSNK1G1	1.40e-04	368	45	6	GO:0030111
GeneOntologyBiologicalProcess	mitochondrion organization	NDUFC2-KCTD14 PLA2G6 ECSIT NME3 ATP2A1 ATAD3A NDUFC2	2.64e-04	589	45	7	GO:0007005
GeneOntologyBiologicalProcess	epithelial cell development	TMOD1 CRYGB MYO1E TJP1 EXPH5	2.90e-04	269	45	5	GO:0002064
GeneOntologyBiologicalProcess	positive regulation of Wnt signaling pathway	USP8 LRRK1 CSNK1G2 CSNK1G1	3.87e-04	158	45	4	GO:0030177
GeneOntologyBiologicalProcess	mitochondrial respiratory chain complex I assembly	NDUFC2-KCTD14 ECSIT NDUFC2	4.03e-04	66	45	3	GO:0032981
GeneOntologyBiologicalProcess	NADH dehydrogenase complex assembly	NDUFC2-KCTD14 ECSIT NDUFC2	4.03e-04	66	45	3	GO:0010257
GeneOntologyCellularComponent	platelet dense tubular network membrane	ATP2A1 ITPR2	1.84e-04	9	48	2	GO:0031095
GeneOntologyCellularComponent	cell cortex	TMOD1 EXOC1 CTNND1 MYO1E CSNK1G2 ITPR2	1.96e-04	371	48	6	GO:0005938
GeneOntologyCellularComponent	platelet dense tubular network	ATP2A1 ITPR2	2.80e-04	11	48	2	GO:0031094
GeneOntologyCellularComponent	hippocampal mossy fiber to CA3 synapse	NECTIN3 CTNND1 SHANK2	4.91e-04	67	48	3	GO:0098686
GeneOntologyCellularComponent	asymmetric synapse	USP8 CHD4 NECTIN3 CTNND1 SHANK2 SHISA6	7.45e-04	477	48	6	GO:0032279
Domain	NDUF_C2	NDUFC2-KCTD14 NDUFC2	6.20e-06	2	47	2	PF06374
Domain	NADH-UbQ_OxRdtase_b14.5b_su	NDUFC2-KCTD14 NDUFC2	6.20e-06	2	47	2	IPR009423
Domain	CK1gamma_C	CSNK1G2 CSNK1G1	1.86e-05	3	47	2	PF12605
Domain	Casein_kinase-1_gamma_C	CSNK1G2 CSNK1G1	1.86e-05	3	47	2	IPR022247
Domain	HMG_boxA_CS	HMGB2 HMGB3	1.86e-05	3	47	2	IPR017967
Domain	HMG_box_2	HMGB2 HMGB3	2.21e-04	9	47	2	PF09011
Domain	HMG_BOX_1	HMGB2 HMGB3	2.75e-04	10	47	2	PS00353
Domain	Dynein_heavy_chain_D4_dom	DNAH12 DYNC2H1	5.53e-04	14	47	2	IPR024317
Domain	Dynein_heavy_dom-2	DNAH12 DYNC2H1	5.53e-04	14	47	2	IPR013602
Domain	DHC_N2	DNAH12 DYNC2H1	5.53e-04	14	47	2	PF08393
Domain	AAA_8	DNAH12 DYNC2H1	5.53e-04	14	47	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH12 DYNC2H1	5.53e-04	14	47	2	IPR011704
Domain	AAA_5	DNAH12 DYNC2H1	5.53e-04	14	47	2	PF07728
Domain	HMG_box_dom	HMGB2 HMGB3 CHD4	5.85e-04	65	47	3	IPR009071
Domain	DHC_fam	DNAH12 DYNC2H1	6.37e-04	15	47	2	IPR026983
Domain	CRYSTALLIN_BETA_GAMMA	CRYGB CRYGD	6.37e-04	15	47	2	PS50915
Domain	Dynein_heavy_dom	DNAH12 DYNC2H1	6.37e-04	15	47	2	IPR004273
Domain	Crystall	CRYGB CRYGD	6.37e-04	15	47	2	PF00030
Domain	Beta/gamma_crystallin	CRYGB CRYGD	6.37e-04	15	47	2	IPR001064
Domain	Dynein_heavy	DNAH12 DYNC2H1	6.37e-04	15	47	2	PF03028
Domain	XTALbg	CRYGB CRYGD	6.37e-04	15	47	2	SM00247
Domain	G_crystallin-rel	CRYGB CRYGD	9.24e-04	18	47	2	IPR011024
Domain	-	CHD4 LRRK1 DNAH12 MYO1E TJP1 DYNC2H1 ATAD3A	2.46e-03	746	47	7	3.40.50.300
Domain	P-loop_NTPase	CHD4 LRRK1 DNAH12 MYO1E TJP1 DYNC2H1 ATAD3A	5.00e-03	848	47	7	IPR027417
Domain	PDZ	SHANK2 TJP1 RGS3	5.36e-03	141	47	3	PF00595
Domain	AAA+_ATPase	DNAH12 DYNC2H1 ATAD3A	5.68e-03	144	47	3	IPR003593
Domain	AAA	DNAH12 DYNC2H1 ATAD3A	5.68e-03	144	47	3	SM00382
Domain	PDZ	SHANK2 TJP1 RGS3	6.13e-03	148	47	3	SM00228
Domain	-	SHANK2 TJP1 RGS3	6.36e-03	150	47	3	2.30.42.10
Domain	PDZ	SHANK2 TJP1 RGS3	6.48e-03	151	47	3	PS50106
Domain	PDZ	SHANK2 TJP1 RGS3	6.59e-03	152	47	3	IPR001478
Pubmed	Helicobacter pylori alters the distribution of ZO-1 and p120ctn in primary human gastric epithelial cells.	CTNND1 TJP1	1.87e-06	2	48	2	17509776
Pubmed	Myosin 1e is a component of the glomerular slit diaphragm complex that regulates actin reorganization during cell-cell contact formation in podocytes.	MYO1E TJP1	1.87e-06	2	48	2	23761676
Pubmed	Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant congenital cerulean cataracts.	CRYGB CRYGD	1.87e-06	2	48	2	12676897
Pubmed	NDUFC2 deficiency exacerbates endothelial mesenchymal transformation during ischemia-reperfusion via NLRP3.	NDUFC2-KCTD14 NDUFC2	1.87e-06	2	48	2	37506315
Pubmed	Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases.	CSTF3 HMGB3 MYO1E TJP1 ATAD3A MRPS14	3.22e-06	295	48	6	26209609
Pubmed	Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles.	DNAH12 DYNC2H1	5.59e-06	3	48	2	8666668
Pubmed	Gamma-crystallin family of the mouse lens: structural and evolutionary relationships.	CRYGB CRYGD	5.59e-06	3	48	2	6096855
Pubmed	The gamma-crystallins and human cataracts: a puzzle made clearer.	CRYGB CRYGD	5.59e-06	3	48	2	10521291
Pubmed	Bioinformatics analysis of the prognosis and biological significance of HMGB1, HMGB2, and HMGB3 in gastric cancer.	HMGB2 HMGB3	5.59e-06	3	48	2	31621076
Pubmed	Afadin controls p120-catenin-ZO-1 interactions leading to endothelial barrier enhancement by oxidized phospholipids.	CTNND1 TJP1	5.59e-06	3	48	2	21732359
Pubmed	Three murine cataract mutants (Cat2) are defective in different gamma-crystallin genes.	CRYGB CRYGD	5.59e-06	3	48	2	9782080
Pubmed	Multiple gamma-crystallins of the mouse lens: fractionation of mRNAs by cDNA cloning.	CRYGB CRYGD	5.59e-06	3	48	2	6953430
Pubmed	Methylation and carbamylation of human gamma-crystallins.	CRYGB CRYGD	5.59e-06	3	48	2	12876325
Pubmed	A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.	CSTF3 HMGB3 CHD4 RPA1 ATP2A1 TJP1 ATAD3A MRPS14	1.11e-05	786	48	8	29128334
Pubmed	The mouse eye lens obsolescence (Elo) mutant: studies on crystallin gene expression and linkage analysis between the mutant locus and the gamma-crystallin genes.	CRYGB CRYGD	1.12e-05	4	48	2	3428594
Pubmed	Novel mutations in the gamma-crystallin genes cause autosomal dominant congenital cataracts.	CRYGB CRYGD	1.12e-05	4	48	2	12011157
Pubmed	Homology models of human gamma-crystallins: structural study of the extensive charge network in gamma-crystallins.	CRYGB CRYGD	1.12e-05	4	48	2	12507494
Pubmed	Genetic and allelic heterogeneity of Cryg mutations in eight distinct forms of dominant cataract in the mouse.	CRYGB CRYGD	1.12e-05	4	48	2	15037589
Pubmed	Assignment of the human gamma-crystallin gene cluster (CRYG) to the long arm of chromosome 2, region q33-36.	CRYGB CRYGD	1.12e-05	4	48	2	3011643
Pubmed	TEAD1, MYO7A and NDUFC2 are novel functional genes associated with glucose metabolism in BXD recombinant inbred population.	NDUFC2-KCTD14 NDUFC2	1.12e-05	4	48	2	38385898
Pubmed	Reduced levels of gamma-crystallin transcripts during embryonic development of murine Cat2nop mutant lenses.	CRYGB CRYGD	1.12e-05	4	48	2	8626090
Pubmed	Temporal regulation of six crystallin transcripts during mouse lens development.	CRYGB CRYGD	1.12e-05	4	48	2	1623964
Pubmed	Partially folded aggregation intermediates of human gammaD-, gammaC-, and gammaS-crystallin are recognized and bound by human alphaB-crystallin chaperone.	CRYGB CRYGD	1.12e-05	4	48	2	20621668
Pubmed	Differential regulation of gamma-crystallin genes during mouse lens development.	CRYGB CRYGD	1.12e-05	4	48	2	3792630
Pubmed	Allelism tests of 15 dominant cataract mutations in mice.	CRYGB CRYGD	1.12e-05	4	48	2	1511869
Pubmed	Nectins establish a checkerboard-like cellular pattern in the auditory epithelium.	NECTIN3 TJP1	1.86e-05	5	48	2	21798896
Pubmed	Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells.	CTNND1 TJP1	1.86e-05	5	48	2	19332538
Pubmed	Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1.	CSNK1G2 CSNK1G1	1.86e-05	5	48	2	21680713
Pubmed	Structure of the crystallins.	CRYGB CRYGD	1.86e-05	5	48	2	10627816
Pubmed	The crystallins: genes, proteins and diseases.	CRYGB CRYGD	1.86e-05	5	48	2	9426193
Pubmed	HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses.	HMGB2 HMGB3	1.86e-05	5	48	2	19890330
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	TMOD1 NDUFC2-KCTD14 EXOC1 CTNND1 SHANK2 MYO1E TJP1 ATAD3A NDUFC2 ITPR2	2.11e-05	1431	48	10	37142655
Pubmed	Gamma-crystallins of the human eye lens: expression analysis of five members of the gene family.	CRYGB CRYGD	2.79e-05	6	48	2	3670288
Pubmed	The cell adhesion gene PVRL3 is associated with congenital ocular defects.	NECTIN3 TJP1	2.79e-05	6	48	2	21769484
Pubmed	Binding between the junctional proteins afadin and PLEKHA7 and implication in the formation of adherens junction in epithelial cells.	NECTIN3 CTNND1	2.79e-05	6	48	2	23990464
Pubmed	Human gamma-crystallin genes. A gene family on its way to extinction.	CRYGB CRYGD	2.79e-05	6	48	2	2258929
Pubmed	Expression patterns of nectins and afadin during epithelial remodeling in the mouse embryo.	NECTIN3 TJP1	2.79e-05	6	48	2	15108322
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	CSTF3 SLU7 HMGB2 HMGB3 CHD4 ATP2A1 TJP1 ATAD3A	4.44e-05	954	48	8	36373674
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	USP8 CHD4 RPA1 TJP1	5.16e-05	147	48	4	29576527
Pubmed	Patched Receptors Sense, Interpret, and Establish an Epidermal Hedgehog Signaling Gradient.	CTNND1 TJP1	5.19e-05	8	48	2	27498049
Pubmed	Energy deprivation and a deficiency in downstream metabolic target genes during the onset of embryonic heart failure in RXRalpha-/- embryos.	NDUFC2-KCTD14 NDUFC2	5.19e-05	8	48	2	9425147
Pubmed	Distinct subdomain organization and molecular composition of a tight junction with adherens junction features.	CTNND1 TJP1	5.19e-05	8	48	2	17130295
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	ATP2A1 ITPR2	5.19e-05	8	48	2	19033399
Pubmed	Nectins localize Willin to cell-cell junctions.	NECTIN3 TJP1	5.19e-05	8	48	2	22512338
Pubmed	Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse.	NECTIN3 TJP1	6.67e-05	9	48	2	12515806
Pubmed	Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I.	ECSIT NDUFC2	6.67e-05	9	48	2	32320651
Pubmed	SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis.	CTNND1 TJP1	6.67e-05	9	48	2	19170756
Pubmed	Chromatin accessibility complex subunit 1 enhances tumor growth by regulating the oncogenic transcription of YAP in breast and cervical cancer.	CHD4 CTNND1 TJP1	6.85e-05	57	48	3	38223760
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	CSTF3 TMOD1 CHD4 SCFD1 CTNND1 ECSIT RPA1 ATAD3A MRPS14	7.64e-05	1335	48	9	29229926
Pubmed	Contacts between the commissural axons and the floor plate cells are mediated by nectins.	NECTIN3 TJP1	8.33e-05	10	48	2	15328010
Pubmed	Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.	NECTIN3 TJP1	8.33e-05	10	48	2	15728677
Pubmed	Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice.	CRYGB CRYGD	8.33e-05	10	48	2	9512512
Pubmed	Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.	CSNK1G2 CSNK1G1	8.33e-05	10	48	2	25500533
Pubmed	Regulation of lens fiber cell differentiation by transcription factor c-Maf.	CRYGB CRYGD	8.33e-05	10	48	2	10383433
Pubmed	Plasticity of button-like junctions in the endothelium of airway lymphatics in development and inflammation.	CTNND1 TJP1	8.33e-05	10	48	2	22538088
Pubmed	Phosphoinositide-specific phospholipase C β 1b (PI-PLCβ1b) interactome: affinity purification-mass spectrometry analysis of PI-PLCβ1b with nuclear protein.	CSTF3 HMGB2 HMGB3 CHD4	8.86e-05	169	48	4	23665500
Pubmed	Hereditary Spastic Paraplegia Overview	USP8 AP4B1 ATAD3A	9.24e-05	63	48	3	20301682
Pubmed	Shotgun identification of protein modifications from protein complexes and lens tissue.	CRYGB CRYGD	1.02e-04	11	48	2	12060738
Pubmed	Disruption of Trkb-mediated signaling induces disassembly of postsynaptic receptor clusters at neuromuscular junctions.	CRYGB CRYGD	1.02e-04	11	48	2	10595510
Pubmed	Mutations in C1orf194, encoding a calcium regulator, cause dominant Charcot-Marie-Tooth disease.	CFAP276 ATP2A1	1.02e-04	11	48	2	31199454
Pubmed	Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract.	CRYGB CRYGD	1.02e-04	11	48	2	12446761
Pubmed	TMEM70 and TMEM242 help to assemble the rotor ring of human ATP synthase and interact with assembly factors for complex I.	ECSIT NDUFC2	1.02e-04	11	48	2	33753518
Pubmed	E2F1 mediates ectopic proliferation and stage-specific p53-dependent apoptosis but not aberrant differentiation in the ocular lens of Rb deficient fetuses.	CRYGB CRYGD	1.02e-04	11	48	2	11146559
Pubmed	Cooperation of nectin-1 and nectin-3 is required for normal ameloblast function and crown shape development in mouse teeth.	NECTIN3 TJP1	1.02e-04	11	48	2	21038445
Pubmed	Igf1r signaling is indispensable for preimplantation development and is activated via a novel function of E-cadherin.	CTNND1 TJP1	1.02e-04	11	48	2	22479204
Pubmed	The NuRD chromatin-remodeling enzyme CHD4 promotes embryonic vascular integrity by transcriptionally regulating extracellular matrix proteolysis.	CHD4 TJP1	1.02e-04	11	48	2	24348274
Pubmed	Altered aggregation properties of mutant gamma-crystallins cause inherited cataract.	CRYGB CRYGD	1.22e-04	12	48	2	12426373
Pubmed	Synergistic action of nectins and cadherins generates the mosaic cellular pattern of the olfactory epithelium.	NECTIN3 TJP1	1.22e-04	12	48	2	26929452
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	NECTIN3 CTNND1 MYO1E EXPH5 CSNK1G2 PLXNB1	1.28e-04	569	48	6	30639242
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	TMOD1 EXOC1 CHD4 SCFD1 ECSIT MYO1E RPA1 ATAD3A ITPR2	1.36e-04	1440	48	9	30833792
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	NDUFC2-KCTD14 CHD4 SCFD1 POGLUT2 NME3 TJP1 ATAD3A NDUFC2 TMEM181	1.44e-04	1451	48	9	30550785
Pubmed	WDR1-regulated actin dynamics is required for outflow tract and right ventricle development.	TMOD1 TJP1	1.44e-04	13	48	2	29654745
Pubmed	Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia.	CTNND1 TJP1	1.44e-04	13	48	2	28482867
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	SHANK2 TJP1 SHISA6 CSNK1G1	1.60e-04	197	48	4	36604605
Pubmed	The orchestration of mammalian tissue morphogenesis through a series of coherent feed-forward loops.	CRYGB CRYGD	1.68e-04	14	48	2	21998302
Pubmed	Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities.	NECTIN3 TJP1	1.68e-04	14	48	2	24381198
Pubmed	Patched1 is required in neural crest cells for the prevention of orofacial clefts.	CTNND1 TJP1	1.68e-04	14	48	2	23900075
Pubmed	The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence.	CTNND1 TJP1	1.68e-04	14	48	2	22144466
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH12 DYNC2H1	1.68e-04	14	48	2	9373155
Pubmed	Quantitative single cell analysis of cell population dynamics during submandibular salivary gland development and differentiation.	CTNND1 TJP1	1.68e-04	14	48	2	23789091
Pubmed	The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes.	NDUFC2-KCTD14 CPT1B ECSIT ATAD3A NDUFC2	1.81e-04	382	48	5	29222160
Pubmed	Human chromosome 11 DNA sequence and analysis including novel gene identification.	CSTF3 SHANK2 EHF	1.88e-04	80	48	3	16554811
Pubmed	Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development.	CTNND1 TJP1	1.94e-04	15	48	2	18393386
Pubmed	Prox1 function is crucial for mouse lens-fibre elongation.	CRYGB CRYGD	1.94e-04	15	48	2	10080188
Pubmed	Association of CPI-17 with protein kinase C and casein kinase I.	CSNK1G2 CSNK1G1	1.94e-04	15	48	2	15003508
Pubmed	FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.	CSTF3 CTNND1 TJP1 ATAD3A	2.12e-04	212	48	4	33462405
Pubmed	Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.	CHD4 MYO1E RPA1 TJP1 ATAD3A ITPR2	2.14e-04	626	48	6	33644029
Pubmed	Constraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification.	CHD4 TJP1	2.21e-04	16	48	2	26116663
Pubmed	Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation.	CRYGB CRYGD	2.21e-04	16	48	2	15593327
Pubmed	Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.	CTNND1 SHANK2 TJP1	2.33e-04	86	48	3	10862698
Pubmed	HSF4 is required for normal cell growth and differentiation during mouse lens development.	CRYGB CRYGD	2.50e-04	17	48	2	15483628
Pubmed	Identification of casein kinase Ialpha interacting protein partners.	HMGB2 CSNK1G2	2.50e-04	17	48	2	12062430
Pubmed	Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1.	TJP1 DYNC2H1	2.50e-04	17	48	2	22357932
Pubmed	Differentially expressed genes in the lens of mimecan-null mice.	CRYGD ATP2A1	2.50e-04	17	48	2	15215744
Pubmed	Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner.	SLU7 EXOC1 DNAH12 ATAD3A	2.52e-04	222	48	4	35941108
Pubmed	Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation.	CRYGB CRYGD	2.81e-04	18	48	2	16162653
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	CSTF3 CTNND1 RPA1 TJP1 ATAD3A CSNK1G1	2.85e-04	660	48	6	32780723
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	HMGB2 CHD4 SCFD1 RPA1 ATP2A1 ATAD3A	2.96e-04	665	48	6	30457570
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	SLU7 HMGB2 CTNND1 MYO1E TJP1 ATAD3A EXPH5 ITPR2	2.97e-04	1257	48	8	36526897
Pubmed	p120 catenin is required for normal renal tubulogenesis and glomerulogenesis.	CTNND1 TJP1	3.14e-04	19	48	2	21521738
Interaction	COA1 interactions	ECSIT RPA1 ATP2A1 NDUFC2	9.70e-07	32	48	4	int:COA1
Cytoband	11q14.1	NDUFC2-KCTD14 NDUFC2	8.97e-04	42	48	2	11q14.1
Cytoband	Ensembl 112 genes in cytogenetic band chr11p13	CSTF3 EHF	2.13e-03	65	48	2	chr11p13
GeneFamily	Canonical high mobility group	HMGB2 HMGB3	1.76e-04	11	33	2	511
GeneFamily	Beta-gamma crystallins	CRYGB CRYGD	3.34e-04	15	33	2	1359
GeneFamily	PDZ domain containing	SHANK2 TJP1 RGS3	2.64e-03	152	33	3	1220
ToppCell	BAL-Severe-Epithelial-Epithelial\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CFAP276 DNAH12 TJP1 EXPH5 PLXNB1 EHF	7.52e-08	200	48	6	b9cede2e0939c6b60ce1aa16d7efaaae79354580
ToppCell	BAL-Severe-Epithelial\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CFAP276 DNAH12 TJP1 EXPH5 PLXNB1 EHF	7.52e-08	200	48	6	b762bf6f432eac05a476f6e2ab4da27dd13a2317
ToppCell	BAL-Severe-Epithelial-Epithelial\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CFAP276 DNAH12 TJP1 EXPH5 PLXNB1 EHF	7.52e-08	200	48	6	4c63204e0d868dd4c11c1604a238624a3ad54485
ToppCell	Severe_COVID-19-Epithelial\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	CFAP276 DNAH12 TJP1 EXPH5 PLXNB1 EHF	7.52e-08	200	48	6	49910efb6d888c208cd50530b03af19f87070630
ToppCell	BAL-Severe-Epithelial\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CFAP276 DNAH12 TJP1 EXPH5 PLXNB1 EHF	7.52e-08	200	48	6	0cc7ff7b6a4eb05d2370ec2f3b9dbfe8cb0699de
ToppCell	IPF-Epithelial\|IPF / Disease state, Lineage and Cell class	CFAP276 DNAH12 SHANK2 DYNC2H1 EHF	2.19e-06	196	48	5	87d9881cfec461a5d89b688a83749b618c519485
ToppCell	Severe_COVID-19-Epithelial-transitional_Epi\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	CFAP276 TJP1 DYNC2H1 EXPH5 PLXNB1	2.25e-06	197	48	5	5ad3cd4c77016e862041baac3076f8cc0f75c417
ToppCell	BL-critical-LOC-Epithelial\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP276 DNAH12 TJP1 EXPH5 EHF	2.30e-06	198	48	5	6218a25b94d5fa2c69880539adf9c63bfe52dcd3
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CTNND1 TJP1 EXPH5 PLXNB1 EHF	2.42e-06	200	48	5	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	NS-control\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CTNND1 TJP1 EXPH5 PLXNB1 EHF	2.42e-06	200	48	5	ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCell	COVID-19-Epithelial_cells-Airway_mucous\|COVID-19 / group, cell type (main and fine annotations)	CRYGD DNAH12 SHANK2 EHF	2.11e-05	151	48	4	8216462e723fec2797387929dde095370947e10a
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HMGB3 SHANK2 POGLUT2 PLXNB1	2.65e-05	160	48	4	af84da18c85037f49f55e8958f00f12140226982
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HMGB3 SHANK2 POGLUT2 PLXNB1	2.65e-05	160	48	4	f7ca98beaa24f9674d503588eb15d341c4135d77
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HMGB3 SHANK2 POGLUT2 PLXNB1	2.65e-05	160	48	4	a76ad44b5f25f59d6b9333fb45f8bb96196a3090
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRRK1 NECTIN3 CTNND1 SPHKAP	3.94e-05	177	48	4	f902600c639087664316b3cf30cab243bc3d1c5c
ToppCell	Children_(3_yrs)-Epithelial-basal_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HMGB3 SHANK2 PLXNB1 EHF	4.02e-05	178	48	4	fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TMOD1 MYO1E TJP1 EXPH5	4.11e-05	179	48	4	7394e77e665bf16d3733df91bb12907be460ab44
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-epithelial_progenitor_cell-TA\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HMGB2 EXPH5 PLXNB1 EHF	4.20e-05	180	48	4	271ee52ed8f21f78ddf68e52fc88fe582701675e
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TMOD1 MYO1E TJP1 EXPH5	4.29e-05	181	48	4	5bf7aa43f6e6ecce15c95928b91195544d6928c4
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TMOD1 MYO1E TJP1 EXPH5	4.29e-05	181	48	4	8e751f5d7cd2d328ec0196d874e8a507e8c4e1a9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMOD1 MYO1E TJP1 EXPH5	4.67e-05	185	48	4	9197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMOD1 MYO1E TJP1 EXPH5	4.67e-05	185	48	4	ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCell	COVID-19-Epithelial_cells-Airway_basal\|COVID-19 / group, cell type (main and fine annotations)	HMGB3 SHANK2 PLXNB1 EHF	4.87e-05	187	48	4	8407a82e98f56a94ea26562bcb6bbe00a8f41661
ToppCell	droplet-Marrow-nan-24m-Hematologic-erythroblast\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMOD1 HMGB3 NME3 RPA1	5.08e-05	189	48	4	98ace332c3c046694c6ade47de8c8bf57ec51271
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMGB3 NECTIN3 ATAD3A EXPH5	5.18e-05	190	48	4	36e83995021ba16690f84e2077a9e8baec547d05
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-intestinal_crypt_stem_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMGB3 NECTIN3 ATAD3A NXT2	5.18e-05	190	48	4	c0ee404d705b0b4f0c6ded4d070ad85eac4b16db
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMGB3 NECTIN3 ATAD3A EXPH5	5.18e-05	190	48	4	d26be9e1b676f750e716b91ebc3598fac3735612
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCFD1 NECTIN3 EXPH5 SPHKAP	5.29e-05	191	48	4	f76f3f5c7902a3659d8cbe470f96ce57c8a6744d
ToppCell	COPD-Epithelial\|COPD / Disease state, Lineage and Cell class	CFAP276 SHANK2 EXPH5 EHF	5.40e-05	192	48	4	0644fad5df18f0021f6f49cca996d8cf47f972ff
ToppCell	Control-Epithelial-Club\|Control / Disease state, Lineage and Cell class	SHANK2 TJP1 EXPH5 EHF	5.40e-05	192	48	4	d84ed1ea4a03edaa18c804f75afb03bd7b1f0e16
ToppCell	IPF-Epithelial-Ciliated\|IPF / Disease state, Lineage and Cell class	CFAP276 DNAH12 SHANK2 DYNC2H1	5.40e-05	192	48	4	354adc1354bf596fbc60dd45c0169688e6f45165
ToppCell	ASK440-Epithelial-Secretory\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	HMGB3 EXPH5 PLXNB1 EHF	5.51e-05	193	48	4	50e98d91697c7af6a3de39e52edde6dd2b67b512
ToppCell	Control-Epithelial-Ciliated\|World / Disease state, Lineage and Cell class	CFAP276 DNAH12 SHANK2 DYNC2H1	5.62e-05	194	48	4	958e648138676d46698090b4046cb484083ae449
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	CFAP276 DNAH12 SHANK2 DYNC2H1	5.73e-05	195	48	4	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	CFAP276 DNAH12 SHANK2 DYNC2H1	5.73e-05	195	48	4	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	IPF-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	CFAP276 DNAH12 SHANK2 DYNC2H1	5.73e-05	195	48	4	21dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TMOD1 LRRK1 NECTIN3 EXPH5	5.85e-05	196	48	4	9790340c25f446ec655f5a0b64ec3bb44ed2e1bd
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TMOD1 LRRK1 NECTIN3 EXPH5	5.85e-05	196	48	4	b9ceceeacbcf81976ce92adf044f0d0aa132632b
ToppCell	mLN-T_cell-gd_T\|T_cell / Region, Cell class and subclass	PUS1 DNAH12 MYO1E PLXNB1	5.85e-05	196	48	4	8f476408cd5a4ea9d25c763c66565343d7989b38
ToppCell	COVID-19-Epithelial\|COVID-19 / Condition, Lineage and Cell class	CFAP276 DNAH12 EXPH5 EHF	5.97e-05	197	48	4	18fd7344628a87d5c7ef5efb66e260a4136245bf
ToppCell	Bronchial_Brush-Epithelial\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	CFAP276 DNAH12 DYNC2H1 EHF	5.97e-05	197	48	4	272c7f4e582ef57564450540242b0db766b78328
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PLA2G6 SHANK2 EXPH5 PLXNB1	6.08e-05	198	48	4	b598ab958e31f1e98bd06dc0097b58ac3a3f90a3
ToppCell	PBMC-Convalescent-Lymphocyte-B-Plasmablast-Plasmablast-Developping_Plasmablast\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HMGB2 HMGB3 ATAD3A NDUFC2	6.08e-05	198	48	4	10a091f7c713123865f316442f10a63493126a1c
ToppCell	NS-critical-d_07-13\|critical / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CTNND1 TJP1 EXPH5 EHF	6.08e-05	198	48	4	a6e11c87b31beffb6af190c64b4ef3ee1d9dab8d
ToppCell	PSB-critical-LOC-Epithelial\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP276 TJP1 EXPH5 EHF	6.20e-05	199	48	4	58dcb0eedafa8629585dc99e53147e2287f49689
ToppCell	NS-critical-d_16-33-Epithelial\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP276 TJP1 EXPH5 EHF	6.20e-05	199	48	4	3b68197ec01c5f2b315d9e9b6eb02d5f6b5b77a3
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PLA2G6 SHANK2 EXPH5 PLXNB1	6.20e-05	199	48	4	d43c605a4ff221cf78d91678c15d2ad20f831c7f
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP276 DNAH12 SHANK2 DYNC2H1	6.20e-05	199	48	4	92fdf6e2f0786ab2ab78126e9131a93794168139
ToppCell	Tracheal-10x3prime_v2-Epithelial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	HMGB3 CFAP276 DNAH12 EHF	6.33e-05	200	48	4	e1da1b15d2ca06796ee1ab7cef586ae0b4dc0a0a
ToppCell	Bronchial-10x5prime-Epithelial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DNAH12 EXPH5 PLXNB1 EHF	6.33e-05	200	48	4	d3ee5f79513e2ac02ad3329b59e6290d457c44d2
ToppCell	Parenchyma_COVID-19-Epithelial-TX\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	CFAP276 DNAH12 EXPH5 EHF	6.33e-05	200	48	4	d5426cd318a8f90c0bd8f9804351ab230fafc995
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CFAP276 DNAH12 EXPH5 EHF	6.33e-05	200	48	4	21d9cf3cd3696ad6b745c7c036798f04b6ce5160
ToppCell	Biopsy_IPF-Epithelial\|Biopsy_IPF / Sample group, Lineage and Cell type	CFAP276 DNAH12 DYNC2H1 EHF	6.33e-05	200	48	4	76f1ac00b34d07057d8da03d276438b719b46b1d
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	PLA2G6 SHANK2 EXPH5 PLXNB1	6.33e-05	200	48	4	ddfb1f006365bf16203ee49f20200f68220cc288
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PLA2G6 SHANK2 EXPH5 PLXNB1	6.33e-05	200	48	4	8683445ad5b70748c4a1f12eb77d47623085147e
ToppCell	Bronchus_Control_(B.)-Epithelial-TX\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	HMGB3 DNAH12 EXPH5 EHF	6.33e-05	200	48	4	f5bc7d30aa03dd0f95eb64255bd1a2543be8d327
ToppCell	Lung_Parenchyma-Severe-Epithelial\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	CFAP276 DNAH12 EXPH5 EHF	6.33e-05	200	48	4	33658d5d09e2eaff60f4dd88837d4252328eab63
ToppCell	metastatic_Lymph_Node-Epithelial_cells\|metastatic_Lymph_Node / Location, Cell class and cell subclass	HMGB3 TJP1 EXPH5 EHF	6.33e-05	200	48	4	07408011b37d32a20164866cf5da9dd120985357
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NECTIN3 CPT1B DYNC2H1	4.41e-04	138	48	3	f33cc2a5033aed5d02d175db5e521046a8e11b6c
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|368C / Donor, Lineage, Cell class and subclass (all cells)	MAGEE1 TMEM181 CSNK1G1	5.63e-04	150	48	3	c843bcf98c5fad2ca4339602f721f3fb782ae353
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PUS1 ATP2A1 ATAD3A	5.63e-04	150	48	3	d6b977dd47aa017f6ba762f0c505cd896caa523f
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DNAH12 CPT1B NME3	5.63e-04	150	48	3	53de595376a9fc92491dfd58ff25938b0bf79903
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DNAH12 CPT1B NME3	5.63e-04	150	48	3	e4b40b3243ed26d0c46bf196ac06e148834e7ed2
ToppCell	Basal_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	HMGB3 PLXNB1 EHF	5.85e-04	152	48	3	72499e4d2b374ef5f1621c89d94727ecf4bd4d5d
ToppCell	Control-PLT_4\|World / Disease Group and Platelet Clusters	CSTF3 DNAH12 RGS3	6.08e-04	154	48	3	a2a03c5e6759c45aeeedf1e68ecb5a0112ef9a20
ToppCell	BAL-Control-cDC_12\|Control / Compartment, Disease Groups and Clusters	HMGB2 PCGF2 RPA1	6.08e-04	154	48	3	0121d08cc527aed9b3e11ff62bb9012916f5c56b
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HMGB3 PLXNB1 EHF	6.43e-04	157	48	3	6ee2692f705bdd93ba523dffaf2f0cd921b47e28
ToppCell	3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP276 DNAH12 CPT1B	6.67e-04	159	48	3	5543f5aec6352a7c5923e55daf3ed40ff5cc0f0c
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related-Tuft\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPHKAP EHF ITPR2	6.91e-04	161	48	3	f5df8c6a340d5026726804b103e32137f363ca40
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MAGEE1 TMEM181 CSNK1G1	7.04e-04	162	48	3	ca30d9bf61f4133566fdc91c7996e130ea554d01
ToppCell	Ciliated_cells-A-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	CFAP276 DNAH12 SHISA6	7.16e-04	163	48	3	43194c6127df1ce3d29242f719645de3c11fd7c0
ToppCell	Ciliated_cells-B-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	CFAP276 DNAH12 DYNC2H1	7.29e-04	164	48	3	fd30c55d0d75ef8b9396435d836187168095152b
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EECs\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DNAH12 CPT1B PLXNB1	7.42e-04	165	48	3	4b4e75ad0eb0a6b00c30a000ec6267e23ba2e496
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CFAP276 SHANK2 EHF	7.42e-04	165	48	3	82530f96aaefe28a13bad0474bbad043f127a86c
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CFAP276 SHANK2 EHF	7.42e-04	165	48	3	0c714e852f912b5749de4cb0895406673979b2e6
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HMGB3 SHISA6 EHF	7.55e-04	166	48	3	9e98e6070055bfc780becee52d77830e06b6d854
ToppCell	facs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TMOD1 CPT1B ATP2A1	7.68e-04	167	48	3	d78356bf0c473816dbabaee51984940bd822f84e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1E TJP1 EXPH5	7.82e-04	168	48	3	fc80e4fecfc92458eb627013a983041d8ca025a9
ToppCell	PND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HMGB2 NT5C3B RPA1	7.95e-04	169	48	3	20fbf78382fb0ba9a63ab1aa0abc615476994ac5
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP276 DNAH12 DYNC2H1	7.95e-04	169	48	3	8bca402e144819cb9a8d431d6bf9429be2fff6d6
ToppCell	facs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAGEE1 DYNC2H1 TMEM181	8.09e-04	170	48	3	d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HMGB3 SHANK2 EHF	8.37e-04	172	48	3	63a91974b12c3f7f0c6bf66c30088d7fc07f5cea
ToppCell	Ciliated_cells-B-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	CFAP276 DNAH12 DYNC2H1	8.37e-04	172	48	3	187ae91148d293537afc77e10da2b64302322224
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	HMGB2 RPA1 DYNC2H1	8.37e-04	172	48	3	7c238a7375341d4647ba7274d93fddfb6fae7ce4
ToppCell	3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP276 DNAH12 DYNC2H1	8.51e-04	173	48	3	c3762655caa79ac4879876f470d32578a3c93b01
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRRK1 CTNND1 SPHKAP	8.51e-04	173	48	3	8ac2e9d39c0f76e674f8bd59d1da246bab4867c8
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-AT2_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NECTIN3 SHANK2 SPHKAP	8.65e-04	174	48	3	d0e3d15731de6c19c232e3aa492c39d8151cf4ed
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D122\|Adult / Lineage, Cell type, age group and donor	SHANK2 SHISA6 EHF	8.94e-04	176	48	3	3fee8a367bb9755aca1b7fcc968b08e51b6e9436
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP276 DNAH12 DYNC2H1	8.94e-04	176	48	3	dee780cfa85234a7cd7bf440b66b84cec959893e
ToppCell	5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP276 DNAH12 PLXNB1	8.94e-04	176	48	3	87de432c680b80555342afac864599bbc002c040
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP276 DNAH12 DYNC2H1	9.09e-04	177	48	3	aef050784abbba45c4ab4e8328339c8739c5c453
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1E TJP1 EXPH5	9.09e-04	177	48	3	4d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCell	IIH-CD8-antiviral_CD4\|IIH / Condition, Cell_class and T cell subcluster	PUS1 TADA2A RGS3	9.09e-04	177	48	3	fe73608c40701eca88b260aeb5c0640d7bee72ba
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HMGB2 HMGB3 EHF	9.09e-04	177	48	3	3081ce5fc66a1bb833719d6c0e0a6fc7115eeb91
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DYNC2H1 EXPH5 PLXNB1	9.09e-04	177	48	3	c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1E TJP1 EXPH5	9.24e-04	178	48	3	edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CRYGD LRRK1 SPHKAP	9.24e-04	178	48	3	b863fc85d2449f25e6cea289459a7bb1f89583fd
ToppCell	facs-Marrow-KLS-24m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMGB3 PCGF2 CTNND1	9.39e-04	179	48	3	5297f7459b40ca780a1983fecc1bb9c035c7677e
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-mature_enterocytic-Paneth\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NDUFC2-KCTD14 HMGB3 EHF	9.39e-04	179	48	3	6405010e8136a4d9bab356f628e36e3194911112
ToppCell	mild_COVID-19_(asymptomatic)-cDC\|World / disease group, cell group and cell class (v2)	CTNND1 MYO1E EHF	9.54e-04	180	48	3	68d1c867734fb2977b01ac686b20bf602f9a6b72
Drug	Fluocinonide [356-12-7]; Down 200; 8uM; MCF7; HT_HG-U133A	TADA2A SHANK2 NXT2 RGS3 CSNK1G2 CSNK1G1	3.63e-06	198	48	6	3839_DN
Drug	Methotrexate [59-05-2]; Down 200; 8.8uM; MCF7; HT_HG-U133A	PCGF2 NECTIN3 EXPH5 RGS3 PLXNB1	3.90e-05	181	48	5	5419_DN
Drug	2-propylpentanoic acid; Up 200; 500uM; HL60; HT_HG-U133A	CRYGD PCGF2 POGLUT2 DYNC2H1 ITPR2	4.91e-05	190	48	5	6199_UP
Drug	Piribedil hydrochloride [78213-63-5]; Down 200; 12uM; MCF7; HT_HG-U133A	TMOD1 PLA2G6 CPT1B NXT2 CSNK1G1	5.04e-05	191	48	5	5434_DN
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT_HG-U133A	PCGF2 POGLUT2 EXPH5 CSNK1G1 ITPR2	5.16e-05	192	48	5	1284_UP
Drug	Rapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A	PLA2G6 CPT1B NXT2 EXPH5 CSNK1G2	5.42e-05	194	48	5	1632_UP
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT_HG-U133A	TMOD1 PCGF2 POGLUT2 DYNC2H1 EXPH5	5.56e-05	195	48	5	2566_UP
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HG-U133A	POGLUT2 NXT2 EXPH5 MRPS14 ITPR2	5.56e-05	195	48	5	1732_UP
Drug	Pyrimethamine [58-14-0]; Down 200; 16uM; MCF7; HT_HG-U133A	TMOD1 PLA2G6 DYNC2H1 RGS3 PLXNB1	5.70e-05	196	48	5	4779_DN
Drug	Dobutamine hydrochloride [49745-95-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	PLA2G6 TADA2A DYNC2H1 NXT2 CSNK1G1	5.70e-05	196	48	5	3206_DN
Drug	Cyclizine hydrochloride [303-25-3]; Down 200; 13.2uM; PC3; HT_HG-U133A	TADA2A LRRK1 SHANK2 NME3 ITPR2	5.83e-05	197	48	5	5100_DN
Drug	Josamycin [16846-24-5]; Down 200; 4.8uM; MCF7; HT_HG-U133A	PCGF2 CPT1B RGS3 PLXNB1 MRPS14	5.83e-05	197	48	5	5692_DN
Drug	Minoxidil [38304-91-5]; Up 200; 19.2uM; MCF7; HT_HG-U133A	NECTIN3 CTNND1 NXT2 CSNK1G1 ITPR2	5.83e-05	197	48	5	4800_UP
Drug	PHA-00846566E [724718-26-7]; Up 200; 10uM; MCF7; HT_HG-U133A	TADA2A PCGF2 SHANK2 CPT1B MYO1E	6.12e-05	199	48	5	7081_UP
Disease	matrix metalloproteinase measurement	PLA2G6 DYNC2H1	1.76e-04	13	45	2	EFO_0004744
Disease	myeloid white cell count	USP8 TADA2A LRRK1 MYO1E PLXNB1 CSNK1G1 MRPS14	5.04e-04	937	45	7	EFO_0007988
Disease	TEMPS-A questionnaire	DYNC2H1 SHISA6	6.67e-04	25	45	2	EFO_0004783

Protein segments in the cluster

Peptide	Gene	Start	Entry
KVEERRERYMDSYDI	NT5C3B	256	Q969T7
RERYMDSYDIVLEKD	NT5C3B	261	Q969T7
QEERERLVRMYFDKY	ATAD3A	526	Q9NVI7
EKDMAVRDRGLFYYR	AP4B1	506	Q9Y6B7
EYEPEMGKVYRADRK	ATP2A1	121	O14983
MRRDAYYFDPEIPKD	CFAP276	56	Q5T5A4
MEKDSYPRFLRSDLY	RGS3	1171	P49796
KAYCVYRREMDPEID	ITPR2	1876	Q14571
DQSKYPIRESEMREY	MAGEE1	506	Q9HCI5
PIRESEMREYIVKEY	MAGEE1	511	Q9HCI5
RPRIVYDEKVDMFSY	LRRK1	1436	Q38SD2
SDKARYDREMKNYVP	HMGB2	66	P26583
NFPEEMATYLRYVRR	CSNK1G1	281	Q9HCP0
ENFPEEMATYLRYVR	CSNK1G2	281	P78368
DIPRYKRMVERYYAD	PLXNB1	2041	O43157
RDYMNARRVAKEYET	CSTF3	211	Q12996
DFDIEMALRKYPVRY	DNAH12	2831	Q6ZR08
KREDYLYAVRDREMF	NDUFC2	76	O95298
DMYRTREPRVFKEDY	EXPH5	296	Q8NEV8
MKRRRDFYAAYPLTE	PCGF2	91	P35227
VMDVKPVDYREYGRR	RPA1	591	P27694
PFEEIRAKYYREMKR	DYNC2H1	791	Q8NCM8
RLYEREDYRGQMIEF	CRYGD	91	P07320
AMRYYYKREILERVD	EHF	266	Q9NZC4
SGAYRMKIYDRDELR	CRYGB	86	P07316
ADKVRYDREMKDYGP	HMGB3	66	O15347
MDYLSRLYEREIKDF	EXOC1	411	Q9NV70
KDPKFAEMEERFYRY	CHD4	601	Q14839
AEMEERFYRYGIKPE	CHD4	606	Q14839
RIEERYRPSMEGYRA	CTNND1	236	O60716
YLALRKMREYGVERD	ECSIT	111	Q9BQ95
SVRPLLDDEEYYRME	CPT1B	191	Q92523
ELRERPFYGRLVKYM	NME3	71	Q13232
FVNIYYETMDKRRRA	NXT2	21	Q9NPJ8
TEEFYRYMLRDIERD	SPHKAP	1191	Q2M3C7
RRYPKEVQDLYETMR	TADA2A	241	O75478
RYILEMYCEEPFVRE	PUS1	261	Q9Y606
RLTDKEADEYYMRRR	SHISA6	316	Q6ZSJ9
YFRMKDEVFRGSRPY	PLA2G6	541	O60733
REKGMYFRRELDRYS	SHANK2	946	Q9UPX8
RDVKRRKMAYEYADE	MRPS14	36	O60783
MSYRRELEKYRDLDE	TMOD1	1	P28289
TPFKDDRYYRLAPMR	TMEM181	131	Q9P2C4
PETDDYRYFDPKMLR	SCFD1	561	Q8WVM8
DERKRPYNSMYETRE	SLU7	546	O95391
YETREPTEEEMEAYR	SLU7	556	O95391
DRKDGSFIVRYRMYA	POGLUT2	91	Q6UW63
KREDYLYAVRDREMF	NDUFC2-KCTD14	76	E9PQ53
HRLRYEDRVPMYEEQ	TJP1	1076	Q07157
RLDRDEERAYVLYMK	USP8	51	P40818
LLEEMRERKYDGYAR	MYO1E	686	Q12965
LNRFERPMDYYEDLK	NECTIN3	501	Q9NQS3