Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP34 CAPNS1 CAPNS2 USP19 CAPN13 USP35 ATG4D	4.50e-05	192	98	7	GO:0008234
GeneOntologyMolecularFunction	cysteine-type endopeptidase activity	USP34 CAPNS1 CAPNS2 CAPN13 ATG4D	6.53e-05	86	98	5	GO:0004197
GeneOntologyMolecularFunction	calcium-dependent cysteine-type endopeptidase activity	CAPNS1 CAPNS2 CAPN13	7.42e-05	17	98	3	GO:0004198
GeneOntologyCellularComponent	calpain complex	CAPNS1 CAPNS2	1.32e-04	4	99	2	GO:0110158
MousePheno	increased magnesium level	CUL3 KCNE2 NR0B1 LONRF3	1.22e-05	26	78	4	MP:0031659
MousePheno	increased circulating magnesium level	CUL3 KCNE2 NR0B1 LONRF3	1.22e-05	26	78	4	MP:0010092
Domain	VWA	COL6A3 COL7A1 COL22A1 C2	2.30e-04	56	100	4	PF00092
Domain	Mob1_phocein	MOB1B MOB1A	5.86e-04	7	100	2	PF03637
Domain	MOB_kinase_act_fam	MOB1B MOB1A	5.86e-04	7	100	2	IPR005301
Domain	-	MOB1B MOB1A	5.86e-04	7	100	2	1.20.140.30
Domain	Mob1_phocein	MOB1B MOB1A	5.86e-04	7	100	2	SM01388
Domain	-	COL6A3 COL7A1 COL22A1 C2	6.68e-04	74	100	4	3.40.50.410
Domain	GAF	EFCAB5 PDE5A	7.78e-04	8	100	2	IPR003018
Domain	GAF	EFCAB5 PDE5A	7.78e-04	8	100	2	SM00065
Domain	VWFA	COL6A3 COL7A1 COL22A1 C2	9.83e-04	82	100	4	PS50234
Domain	Acyl-CoA_DH_CS	ACADVL IVD	9.97e-04	9	100	2	IPR006089
Domain	-	EFCAB5 PDE5A	9.97e-04	9	100	2	3.30.450.40
Domain	GAF_dom-like	EFCAB5 PDE5A	9.97e-04	9	100	2	IPR029016
Domain	VWA	COL6A3 COL7A1 COL22A1 C2	1.08e-03	84	100	4	SM00327
Domain	Collagen	COL6A3 COL7A1 COL22A1 FCN3	1.12e-03	85	100	4	IPR008160
Domain	Collagen	COL6A3 COL7A1 COL22A1 FCN3	1.12e-03	85	100	4	PF01391
Domain	ACYL_COA_DH_1	ACADVL IVD	1.24e-03	10	100	2	PS00072
Domain	ACYL_COA_DH_2	ACADVL IVD	1.24e-03	10	100	2	PS00073
Domain	Acyl-CoA_dh_N	ACADVL IVD	1.51e-03	11	100	2	PF02771
Domain	VWF_A	COL6A3 COL7A1 COL22A1 C2	1.97e-03	99	100	4	IPR002035
Domain	-	ACADVL IVD	2.13e-03	13	100	2	1.10.540.10
Domain	Acyl-CoA_dh_1	ACADVL IVD	2.13e-03	13	100	2	PF00441
Domain	AcylCoA_DH/ox_N	ACADVL IVD	2.13e-03	13	100	2	IPR013786
Domain	Acyl-CoA_Oxase/DH_cen-dom	ACADVL IVD	2.85e-03	15	100	2	IPR006091
Domain	AcylCoA_DH/oxidase_NM_dom	ACADVL IVD	2.85e-03	15	100	2	IPR009100
Domain	Spectrin_alpha_SH3	STAC2 TP53BP2	2.85e-03	15	100	2	IPR013315
Domain	Acyl-CoA_dh_M	ACADVL IVD	2.85e-03	15	100	2	PF02770
Domain	FN3	COL6A3 COL7A1 KALRN TNN EPHA10	3.18e-03	185	100	5	SM00060
Domain	AcylCo_DH/oxidase_C	ACADVL IVD	3.24e-03	16	100	2	IPR009075
Domain	SUGAR_TRANSPORT_2	SLC2A6 SLC22A3	3.66e-03	17	100	2	PS00217
Domain	aa-tRNA-synth_II	DARS2 EIF2AK4	4.11e-03	18	100	2	IPR006195
Domain	-	COL6A3 COL7A1	4.11e-03	18	100	2	4.10.410.10
Domain	Prtase_inh_Kunz-CS	COL6A3 COL7A1	4.11e-03	18	100	2	IPR020901
Domain	AA_TRNA_LIGASE_II	DARS2 EIF2AK4	4.11e-03	18	100	2	PS50862
Domain	FN3	COL6A3 COL7A1 KALRN TNN EPHA10	4.34e-03	199	100	5	PS50853
Domain	Fibrinogen_CS	FCN3 TNN	4.57e-03	19	100	2	IPR020837
Domain	BPTI_KUNITZ_1	COL6A3 COL7A1	4.57e-03	19	100	2	PS00280
Domain	PUA-like_domain	MCTS1 LONRF3	4.57e-03	19	100	2	IPR015947
Domain	BPTI_KUNITZ_2	COL6A3 COL7A1	4.57e-03	19	100	2	PS50279
Domain	Kunitz_BPTI	COL6A3 COL7A1	4.57e-03	19	100	2	PF00014
Domain	FN3_dom	COL6A3 COL7A1 KALRN TNN EPHA10	5.33e-03	209	100	5	IPR003961
Domain	USP_CS	USP34 USP19 USP35	5.34e-03	66	100	3	IPR018200
Domain	USP_1	USP34 USP19 USP35	6.29e-03	70	100	3	PS00972
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	USP34 CABLES2 MAP4K3 GAS6 ACVR2A DARS2 SLC30A6 MOB1B MOB1A EIF2AK4 PIP4K2C BTRC ATG16L2	2.42e-06	910	101	13	36736316
Pubmed	Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling.	MOB1B MOB1A	8.35e-06	2	101	2	30349003
Pubmed	Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice.	MOB1B MOB1A	8.35e-06	2	101	2	23143302
Pubmed	Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice.	KHK ALDOB	8.35e-06	2	101	2	29533924
Pubmed	KCNE2 modulates cardiac L-type Ca(2+) channel.	CACNA1C KCNE2	8.35e-06	2	101	2	24681347
Pubmed	Human Mob1 proteins are required for cytokinesis by controlling microtubule stability.	MOB1B MOB1A	8.35e-06	2	101	2	22454515
Pubmed	Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficits.	CUL3 CHAT	8.35e-06	2	101	2	36693858
Pubmed	Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism.	ACADVL IVD GLDC	8.45e-06	14	101	3	35727412
Pubmed	EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1.	MOB1B MOB1A	2.50e-05	3	101	2	34725466
Pubmed	Genetic map of the fused locus on mouse chromosome 17.	ITPR3 PIM1	2.50e-05	3	101	2	7829069
Pubmed	RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity.	CUL3 PDE5A	2.50e-05	3	101	2	30896450
Pubmed	The human tumour suppressor LATS1 is activated by human MOB1 at the membrane.	MOB1B MOB1A	2.50e-05	3	101	2	16674920
Pubmed	The conversion of (4- 3 H)fructose and of (4- 3 H)glucose to liver glycogen in the mouse. An investigation of the glyceraldehyde crossroads.	KHK ALDOB	2.50e-05	3	101	2	4343087
Pubmed	Luminal cholinergic signalling in airway lining fluid: a novel mechanism for activating chloride secretion via Ca²⁺-dependent Cl⁻ and K⁺ channels.	CHAT SLC22A3	2.50e-05	3	101	2	22300281
Pubmed	Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells.	ITPR3 KIDINS220	2.50e-05	3	101	2	18539593
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	CUL3 COL6A3 MYO1D KALRN SPTBN1 PEPD ATP6V1F FCGBP NAPRT KHK PIP4K2C PLEKHA7	3.97e-05	1016	101	12	19056867
Pubmed	A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.	CUL3 KALRN TP53BP2	4.60e-05	24	101	3	16620772
Pubmed	DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner.	MCTS1 ESX1 RHOXF2B	4.60e-05	24	101	3	17182866
Pubmed	Transcriptional code and disease map for adult retinal cell types.	OPN4 CHAT	4.99e-05	4	101	2	22267162
Pubmed	PTEN-GSK3β-MOB1 axis controls neurite outgrowth in vitro and in vivo.	MOB1B MOB1A	4.99e-05	4	101	2	30069702
Pubmed	Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein.	MOB1B MOB1A	4.99e-05	4	101	2	15197186
Pubmed	Assembly of high order G alpha q-effector complexes with RGS proteins.	KALRN ARHGEF25	8.30e-05	5	101	2	18936096
Pubmed	PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ.	BTRC TP53BP2	8.30e-05	5	101	2	21189257
Pubmed	A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90.	CUL3 BTRC	8.30e-05	5	101	2	35088844
Pubmed	Immunohistochemical Procedures for Characterizing the Retinal Expression Patterns of Cre Driver Mouse Lines.	OPN4 CHAT	8.30e-05	5	101	2	28815501
Pubmed	Stem cell-specific expression of Dax1 is conferred by STAT3 and Oct3/4 in embryonic stem cells.	SLC22A3 NR0B1	8.30e-05	5	101	2	18471437
Pubmed	βTrCP-mediated ubiquitylation regulates protein stability of Mis18β in a cell cycle-dependent manner.	CUL3 BTRC	8.30e-05	5	101	2	24269809
Pubmed	Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains.	CAPNS1 CAPNS2	8.30e-05	5	101	2	17646163
Pubmed	YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma.	MOB1B MOB1A	8.30e-05	5	101	2	32206709
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	CACNA1C USP19 ITPR3 HERC2 PIP4K2C BTRC ATG16L2	1.08e-04	371	101	7	15747579
Pubmed	Calpain activity is negatively regulated by a KCTD7-Cullin-3 complex via non-degradative ubiquitination.	CUL3 CAPNS1 CAPN13	1.22e-04	33	101	3	36964131
Pubmed	Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers.	MOB1B MOB1A	1.24e-04	6	101	2	35858357
Pubmed	Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice.	MOB1B MOB1A	1.24e-04	6	101	2	32716083
Pubmed	XAF1 prevents hyperproduction of type I interferon upon viral infection by targeting IRF7.	CUL3 IRF7	1.24e-04	6	101	2	36394357
Pubmed	ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice.	CACNA1C ITPR3	1.24e-04	6	101	2	16352659
Pubmed	YAP determines the cell fate of injured mouse hepatocytes in vivo.	MOB1B MOB1A	1.24e-04	6	101	2	28681838
Pubmed	MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.	MOB1B MOB1A	1.74e-04	7	101	2	18328708
Pubmed	Molecular characterization of human homologs of yeast MOB1.	MOB1B MOB1A	2.31e-04	8	101	2	19739119
Pubmed	Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4.	COL6A3 COPB1	2.31e-04	8	101	2	10444069
Pubmed	The integrated stress response contributes to tRNA synthetase-associated peripheral neuropathy.	CHAT EIF2AK4	2.31e-04	8	101	2	34516839
Pubmed	High-resolution genetic analysis of a deletion on mouse chromosome 17 extending over the fused, tufted, and homeobox Nkx2-5 loci.	ITPR3 PIM1	2.31e-04	8	101	2	7894168
Pubmed	Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.	MOB1B MOB1A	2.31e-04	8	101	2	26699479
Pubmed	Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1.	CUL3 BTRC	2.31e-04	8	101	2	12684064
Pubmed	Fras1 deficiency results in cryptophthalmos, renal agenesis and blebbed phenotype in mice.	COL6A3 COL7A1	2.31e-04	8	101	2	12766770
Pubmed	Epigenetic modulator inhibition overcomes temozolomide chemoresistance and antagonizes tumor recurrence of glioblastoma.	CUL3 BTRC	2.31e-04	8	101	2	33016927
Pubmed	The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states.	CUL3 KCTD15	2.31e-04	8	101	2	27152988
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	CUL3 SMAP1 MYO1D COPB1 KALRN MAP4K3 SPTBN1 KIDINS220 LRRCC1 PIP4K2C PSPC1 PLEKHA7 TP53BP2	2.59e-04	1431	101	13	37142655
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	COL6A3 MAN2B2 MYO1D GAS6 PEPD EPX FCGBP SERPINI1 NAPRT C2 ALDOB	2.83e-04	1070	101	11	23533145
Pubmed	Peroxisome-Deficiency and HIF-2α Signaling Are Negative Regulators of Ketohexokinase Expression.	KHK ALDOB	2.97e-04	9	101	2	32733884
Pubmed	Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging.	USP34 USP35	2.97e-04	9	101	2	37149635
Pubmed	Non-erythroid beta spectrin interacting proteins and their effects on spectrin tetramerization.	COPB1 SPTBN1	2.97e-04	9	101	2	21866423
Pubmed	Genetic mapping of 10 microsatellites in the t complex region of mouse chromosome 17.	ITPR3 PIM1	3.70e-04	10	101	2	9585437
Pubmed	NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach.	TRADD BTRC	3.70e-04	10	101	2	15485837
Pubmed	Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance.	CUL3 BTRC	3.70e-04	10	101	2	29160310
Pubmed	Regulation of cullin RING E3 ubiquitin ligases by CAND1 in vivo.	CUL3 BTRC	3.70e-04	10	101	2	21249194
Pubmed	Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor.	CUL3 COPB1 KCTD15	4.22e-04	50	101	3	27716508
Pubmed	Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.	KALRN SPTBN1	4.51e-04	11	101	2	17607528
Pubmed	Mapping of the Pim-1 oncogene in mouse t-haplotypes and its use to define the relative map positions of the tcl loci t0(t6) and tw12 and the marker tf (tufted).	ITPR3 PIM1	4.51e-04	11	101	2	1676981
Pubmed	Suramin inhibits cullin-RING E3 ubiquitin ligases.	CUL3 BTRC	4.51e-04	11	101	2	27001857
Pubmed	TIP120A associates with cullins and modulates ubiquitin ligase activity.	CUL3 BTRC	4.51e-04	11	101	2	12609982
Pubmed	Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides.	CHAT ITPR3	5.41e-04	12	101	2	32294408
Pubmed	Overexpression of COP9 signalosome subunits, CSN7A and CSN7B, exerts different effects on adipogenic differentiation.	CUL3 BTRC	6.38e-04	13	101	2	27833851
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	COPB1 MCTS1 PEPD DARS2 GDAP1L1 NAPRT PSPC1	6.39e-04	498	101	7	36634849
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	CAPNS1 ARFGEF1 ATP6V1F SLC30A6 ITPR3 KIDINS220 RMC1	6.86e-04	504	101	7	34432599
Pubmed	An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases.	CUL3 DET1 LRR1	6.87e-04	59	101	3	19295130
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	CUL3 MRPL23 KLHL24 USP19 LRR1 GLDC EIF2AK4 HERC2 PLEKHA7 BTRC	6.95e-04	1005	101	10	19615732
Pubmed	DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina.	OPN4 CHAT	7.43e-04	14	101	2	19945391
Pubmed	Increased Retinoic Acid Catabolism in Olfactory Sensory Neurons Activates Dormant Tissue-Specific Stem Cells and Accelerates Age-Related Metaplasia.	ITPR3 FCGBP	7.43e-04	14	101	2	32385093
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	MRPL23 COL6A3 CAPNS1 IVD NAPRT MOB1A KCTD15 EIF2AK4 USP35 HERC2 PLEKHA7	8.14e-04	1215	101	11	15146197
Pubmed	Mapping of 12 markers in the proximal region of mouse chromosome 17 using recombinant t haplotypes.	ITPR3 PIM1	8.55e-04	15	101	2	7749235
Pubmed	Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.	OPN4 ITPR3	8.55e-04	15	101	2	28578927
Pubmed	New molecular markers for the distal end of the t-complex and their relationships to mutations affecting mouse development.	ITPR3 PIM1	8.55e-04	15	101	2	1350556
Pubmed	Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium.	CHAT ITPR3	8.55e-04	15	101	2	24428937
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	USP34 USP19 DARS2 USP35	9.10e-04	147	101	4	29576527
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	COL6A3 FCN3 FCGBP TNN C2	9.43e-04	257	101	5	16335952
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	KCNE2 MAN2B2 SPTBN1 PEPD RSPO4 IRF7 DARS2 GLDC LONRF3 NME4 ATG16L2	9.73e-04	1242	101	11	30973865
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	MRPL23 USP34 MAN2B2 COPB1 ACADVL H6PD LCMT2 DARS2 SLC30A6 PIP4K2C NME4 PSPC1	1.03e-03	1451	101	12	30550785
Pubmed	Chromosomal locations of the mouse fatty acid oxidation genes Cpt1a, Cpt1b, Cpt2, Acadvl, and metabolically related Crat gene.	ACADVL H6PD	1.10e-03	17	101	2	9680378
Pubmed	WDFY4 is required for cross-presentation in response to viral and tumor antigens.	MYO1D SPTBN1 ATP6V1F TRAPPC8	1.13e-03	156	101	4	30409884
Pubmed	Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.	MOB1B MOB1A PIP4K2C BTRC TP53BP2	1.17e-03	270	101	5	24366813
Pubmed	Identification of host proteins required for HIV infection through a functional genomic screen.	SPTBN1 TRAPPC8 PANK1 STAC2 ATG16L2	1.21e-03	272	101	5	18187620
Pubmed	Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.	CUL3 ACADVL	1.24e-03	18	101	2	26906416
Pubmed	PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth.	ITPR3 BTRC	1.24e-03	18	101	2	28614300
Pubmed	Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS.	USP19 USP35	1.24e-03	18	101	2	30410068
Pubmed	MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation.	MOB1B MOB1A	1.24e-03	18	101	2	28346423
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	MRPL23 ACADVL SPTBN1 ATP6V1F TRAPPC8 HSPA12B LCMT2 DARS2 ITPR3 KIDINS220 HERC2 NME4	1.27e-03	1487	101	12	33957083
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	MRPL23 MYO1D ACADVL ATP6V1F USP19 DARS2 SLC30A6 ITPR3 IVD HERC2 NME4 PSPC1	1.34e-03	1496	101	12	32877691
Pubmed	Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.	H6PD EIF2AK4	1.38e-03	19	101	2	14671302
Pubmed	Long QT Syndrome Overview	CACNA1C KCNE2	1.38e-03	19	101	2	20301308
Pubmed	Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.	MRPL23 COPB1 ACADVL CAPNS1 KIDINS220 NAPRT	1.48e-03	422	101	6	27342126
Pubmed	CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling.	CUL3 BTRC	1.53e-03	20	101	2	23563313
Pubmed	Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function.	OPN4 CHAT	1.69e-03	21	101	2	21835343
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP34 USP19 USP35	1.72e-03	81	101	3	12838346
Pubmed	Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.	ITPR3 ATG16L2	1.86e-03	22	101	2	23850713
Pubmed	Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.	OPN4 FCGBP HERC2	1.91e-03	84	101	3	15203218
Pubmed	Ski regulates Hippo and TAZ signaling to suppress breast cancer progression.	COPB1 MOB1B MOB1A	1.91e-03	84	101	3	25670202
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	USP34 SMAP1 COPB1 ARFGEF1 USP19 SLC30A6 KIDINS220 KIN	1.95e-03	777	101	8	35844135
Pubmed	Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.	USP34 USP35	2.03e-03	23	101	2	14715245
Pubmed	A novel missense variant in CUL3 shows altered binding ability to BTB-adaptor proteins leading to diverse phenotypes of CUL3-related disorders.	CUL3 KLHL24	2.03e-03	23	101	2	33130828
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	ARFGEF1 TRAPPC8 USP19 EIF2AK4	2.04e-03	183	101	4	31932471
Cytoband	Xq24	MCTS1 ATP1B4 RHOXF2B LONRF3	1.27e-05	64	101	4	Xq24
Cytoband	Ensembl 112 genes in cytogenetic band chrXq24	MCTS1 ATP1B4 RHOXF2B LONRF3	3.22e-05	81	101	4	chrXq24
GeneFamily	MOB kinase activators\|STRIPAK complex	MOB1B MOB1A	2.89e-04	7	68	2	647
GeneFamily	Collagens	COL6A3 COL7A1 COL22A1	6.88e-04	46	68	3	490
GeneFamily	Acyl-CoA dehydrogenase family	ACADVL IVD	7.50e-04	11	68	2	974
GeneFamily	Ubiquitin specific peptidases	USP34 USP19 USP35	1.22e-03	56	68	3	366
GeneFamily	Fibronectin type III domain containing	COL7A1 KALRN TNN EPHA10	3.10e-03	160	68	4	555
GeneFamily	Fibrinogen C domain containing	FCN3 TNN	3.95e-03	25	68	2	554
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D175\|Adult / Lineage, Cell type, age group and donor	CACNA1C KALRN ARHGEF25 STAC2 PDE5A NME4	2.26e-06	167	101	6	c4e321bb87512ea839f324c92c0f1afea891483f
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL7A1 CAPNS2 CHAT ITPR3 CAPN13 FCGBP	3.60e-06	181	101	6	a5e770b5b5d57cbac18560828e89f7c96b687743
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL7A1 CAPNS2 CHAT ITPR3 CAPN13 FCGBP	3.60e-06	181	101	6	504b1af1951a7a20ef5db69d84c20630ec64095b
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL7A1 CAPNS2 CHAT ITPR3 CAPN13 FCGBP	3.60e-06	181	101	6	a55ec36d2393f7a376feb42b22aee75dfdf4c383
Disease	Angle Closure Glaucoma	CHAT PLEKHA7	2.31e-04	7	99	2	C0017605
Disease	volumetric bone mineral density	CACNA1C MAP4K3 SPTBN1	3.82e-04	42	99	3	EFO_0007620
Disease	hair colour measurement, eye colour measurement, skin pigmentation measurement	SERPINI1 HERC2	4.93e-04	10	99	2	EFO_0007009, EFO_0007822, EFO_0009764
Disease	gluteofemoral adipose tissue measurement	PEPD H6PD HOXC12 SLC22A3	1.04e-03	132	99	4	EFO_0803317
Disease	Antibody Deficiency Syndrome	CACNA1C FCN3	1.47e-03	17	99	2	C0003257
Disease	obsolete_red blood cell distribution width	CUL3 KLHL24 MYO1D KALRN GAS6 PEPD ALG11 STAC2 PIM1 MOB1B EIF2AK4 BTRC	1.84e-03	1347	99	12	EFO_0005192
Disease	triglyceride measurement, body fat percentage	PEPD SLC22A3	2.24e-03	21	99	2	EFO_0004530, EFO_0007800
Disease	Immunologic Deficiency Syndromes	CACNA1C FCN3	2.69e-03	23	99	2	C0021051

Protein segments in the cluster

Peptide	Gene	Start	Entry
TFRQFLNRDDIGIIL	ATP6V1F	51	Q16864
QILEGAFRRFNIRLI	ALG11	111	Q2TAA5
RRRTAFTQFQLQELE	ESX1	141	Q8N693
LRVSNIRQVFRADGF	ATG16L2	531	Q8NAA4
GRERRVFLFEQIIIF	ARHGEF25	376	Q86VW2
GIIFQFVAFIKRRQR	EIF2AK4	1326	Q9P2K8
NTEENRRQFREILFS	ALDOB	51	P05062
AVLRRFFLRIGVVFQ	ARFGEF1	1821	Q9Y6D6
LEGAINFQRDAFLRI	ACVR2A	371	P27037
GRVFRLQFDEFQIVS	BTRC	556	Q9Y297
LDFQVILAGSQRFRE	CAPN13	406	Q6MZZ7
QRSVNIRGRLFERFF	DET1	111	Q7L5Y6
IRQDFQAGEVAFRRT	CIRBP-AS1	6	Q8TBR5
INDRFVGRVIFTLNI	ATP1B4	341	Q9UN42
LQRFGSQRNEVRFFL	TP53BP2	66	Q13625
RASFLNREVLQRFRG	PEPD	431	P12955
FFERVQRRFAFRKVL	GDAP1L1	301	Q96MZ0
EGFISQNDRRFVIQL	ITPR3	461	Q14573
EFRNDFLELLRRRFG	KIN	71	O60870
LVFQRRQDGSVDFFR	FCN3	131	O75636
GEFLVNEFITRQRRR	HOXC12	231	P31275
GVSRGRDFNQVVRFE	MAP4K3	741	Q8IVH8
DFVFLGLSQTRELQR	OR4D2	11	P58180
EREFGFLATRLFRVF	KIDINS220	626	Q9ULH0
ILTVNGELLFFRQRE	MCTS1	61	Q9ULC4
RGTRYELRENIEQFF	LRR1	56	Q96L50
RTIADFRGRDFVIQV	HERC2	4731	O95714
GAVFLERRFRFFQVG	C2	681	P06681
QVIIGRDRVFTFDFV	KIF27	36	Q86VH2
LFENQFRRARDGDRF	EPX	636	P11678
RRGEFFELIRKNQFN	PDE5A	731	O76074
LEFVREAIQRFDNLR	COPB1	421	P53618
ARDFINVILQEDFRR	KALRN	2911	O60229
NFTQTLEDVFRRIFI	KCNE2	6	Q9Y6J6
FIFFVQEFNLIDRRE	MOB1B	186	Q7L9L4
FQELVEFRARQRRGS	IRF7	411	Q92985
GRGQRIFVELQFTLR	EPHA10	96	Q5JZY3
RIFGEDFIATFKRQR	HSPA12B	366	Q96MM6
EVRRLVIGRAFNADF	IVD	411	P26440
LEQIESFFRTGRRSF	SLC2A6	491	Q9UGQ3
LRFINANVIAELFFR	NR0B1	436	P51843
IFIFRAIRETGRALQ	OPN4	256	Q9UHM6
RNFEVIFQGIRTRDL	MALRD1	1646	Q5VYJ5
NVREVQRAGILFFRI	EFCAB5	1316	A4FU69
NILQIFNEFRDSRLF	KLHL24	51	Q6TFL4
EENSRISITFFRLFR	CACNA1C	1366	Q13936
QVFRQGRDAVVRTDF	FCGBP	961	Q9Y6R7
FVRLVFIVRSEAQRQ	FRMPD3	1706	Q5JV73
FLRPRQRRAFQVFEE	GAS6	41	Q14393
RFDRFLLESFNNDRL	CUL3	351	Q13618
GSINFRRDSFQEVLR	COL6A3	1646	P12111
EEVRRFRQQFTQLAG	CAPNS2	76	Q96L46
EEVRQFRRLFAQLAG	CAPNS1	96	P04632
AVRVVFRGSRVNDLF	COL22A1	346	Q8NFW1
RGQQRRFIAVEQEFF	MAN2B2	66	Q9Y2E5
REQVRFNGFGIFLFI	MBTPS2	181	O43462
FLVADFRRRGVDVSQ	KHK	71	P50053
RSNFREVRSFLEGLV	COL7A1	51	Q02388
IEATAVRAVRRFGQF	H6PD	571	O95479
EALQRVGEFGRFQRR	SLC22A3	6	O75751
VGEFGRFQRRVFLLL	SLC22A3	11	O75751
ERFRFNRRDLIGFEF	CABLES2	436	Q9BTV7
RLGRFREPQIVEFVF	CNTD1	46	Q8N815
QVFRNLRDRFGIDDQ	PIP4K2C	106	Q8TBX8
FFFLIRNRRTGTILF	SERPINI1	376	Q99574
NENIDRVVFVGNFLR	PANK1	536	Q8TE04
EEIIRGQVFFRQRVS	PIM1	246	P11309
RQNTFLVLRDFDGLV	DARS2	76	Q6PI48
QQRLFLFIRREGIRQ	RSPO4	51	Q2I0M5
FQLLRRFVQAEGRRA	TRADD	266	Q15628
FIFFVQEFNLIDRRE	MOB1A	186	Q9H8S9
DVIQRFERRGFTLVG	NME4	56	O00746
RDGRVFFINDQLRCT	PLEKHA7	21	Q6IQ23
CIFQREQFPSEFLRR	RHOXF2B	151	P0C7M4
IFQSERGRFIRDFSR	INTS5	961	Q6P9B9
LQERFREFARDTGNI	SPTBN1	1736	Q01082
VLRDLRIFRIFEGTN	ACADVL	451	P49748
RIFRIFEGTNDILRL	ACADVL	456	P49748
FRQGLRGFREYQIIE	CNBD2	36	Q96M20
RRNRTETRGIQFEDF	CHST10	226	O43529
QFFVLDVVINFRRLS	CHAT	311	P28329
EGDIQRFQRDFVSRL	ATG4D	106	Q86TL0
SRVLFREQDFTLIFQ	USP19	311	O94966
VFQRRNTGQLDFFKR	TNN	1111	Q9UQP3
VFINRDRGFGFIRLE	PSPC1	111	Q8WXF1
TIFRFFEQRNQRLRG	RMC1	611	Q96DM3
QVLERLFQRGFSVAA	KCTD15	231	Q96SI1
DRVGFFPANFVQRVR	STAC2	336	Q6ZMT1
FAEFFSARRVLRLLQ	USP35	76	Q9P2H5
QLRVFRTNFFIQLVR	MRPL23	16	Q16540
FRRPQTDQAVEFFIR	SMAP1	106	Q8IYB5
FLRAFRLRDADVQFL	NAPRT	66	Q6XQN6
IERFFNQQVEILGRR	ZPBP	266	Q9BS86
QRSFFGKLLREFRLV	SLC30A6	11	Q6NXT4
DRIRQFIQEFTFRGL	TRAPPC8	346	Q9Y2L5
FSREGQEFLRDIFNL	USP34	1806	Q70CQ2
ERFPDVEAQRRRFLQ	LCMT2	246	O60294
LEFTRGQRIFVQGQR	WDR87	2036	Q6ZQQ6
GQRRLFELSQTRDFI	WDR64	906	B1ANS9
GRAAQRQINFRLFED	GLDC	451	P23378
NEFRIALTVEARRFQ	LRRCC1	641	Q9C099
ILEIRNVQFFADGRS	LONRF3	611	Q496Y0
LENVRVRRAGFAFRQ	MYO1D	616	O94832