Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmonoatomic ion channel activity

PIEZO1 PKD1L1 GRIK2 ANO10 RYR3 PIEZO2 TRPM5 SCN2A SCN3A SCN9A LRRC8B GABRA1 GABRA5

1.82e-0645911213GO:0005216
GeneOntologyMolecularFunctionchannel activity

PIEZO1 PKD1L1 GRIK2 ANO10 RYR3 PIEZO2 TRPM5 SCN2A SCN3A SCN9A LRRC8B GABRA1 GABRA5

7.83e-0652511213GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

PIEZO1 PKD1L1 GRIK2 ANO10 RYR3 PIEZO2 TRPM5 SCN2A SCN3A SCN9A LRRC8B GABRA1 GABRA5

7.99e-0652611213GO:0022803
GeneOntologyMolecularFunctionsodium channel activity

GRIK2 TRPM5 SCN2A SCN3A SCN9A

1.07e-05521125GO:0005272
GeneOntologyMolecularFunctionmonoatomic cation channel activity

PIEZO1 PKD1L1 GRIK2 ANO10 RYR3 PIEZO2 TRPM5 SCN2A SCN3A SCN9A

2.35e-0534311210GO:0005261
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC26A2 PIEZO1 PKD1L1 GRIK2 ANO10 SLC25A37 RYR3 PIEZO2 TRPM5 SCN2A SCN3A SCN9A LRRC8B GABRA1 GABRA5

3.67e-0579311215GO:0015075
GeneOntologyMolecularFunctionsodium ion binding

SCN2A SCN3A SCN9A

5.98e-05141123GO:0031402
GeneOntologyMolecularFunctionglycogen phosphorylase activity

PYGB PYGL

9.32e-0531122GO:0008184
GeneOntologyMolecularFunctiongated channel activity

PIEZO1 GRIK2 ANO10 RYR3 PIEZO2 TRPM5 SCN2A GABRA1 GABRA5

1.12e-043341129GO:0022836
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH7 DNAH9 DNAH11

1.32e-04181123GO:0008569
GeneOntologyMolecularFunctiontau-protein kinase activity

MARK1 MARK3 MARK2

2.45e-04221123GO:0050321
GeneOntologyMolecularFunctiontransporter activity

TMEM30B SLC26A2 PIEZO1 PKD1L1 PEX6 GRIK2 ANO10 SLC7A11 SLC25A37 RYR3 PIEZO2 TRPM5 SCN2A SCN3A SCN9A LRRC8B GABRA1 GABRA5

2.90e-04128911218GO:0005215
GeneOntologyMolecularFunction1,4-alpha-oligoglucan phosphorylase activity

PYGB PYGL

3.08e-0451122GO:0004645
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

GRIK2 GABRA1 GABRA5

3.19e-04241123GO:0099507
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN2A SCN3A SCN9A

4.07e-04261123GO:0005248
GeneOntologyMolecularFunctionalkali metal ion binding

SCN2A SCN3A SCN9A

4.07e-04261123GO:0031420
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH7 DNAH9 DNAH11

5.08e-04281123GO:0051959
GeneOntologyMolecularFunctioncytoskeletal motor activity

KIF27 DNAH7 MYH15 DNAH9 DNAH11

5.37e-041181125GO:0003774
GeneOntologyMolecularFunctionmicrotubule motor activity

KIF27 DNAH7 DNAH9 DNAH11

6.47e-04701124GO:0003777
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

GRIK2 ANO10 RYR3 TRPM5 GABRA1 GABRA5

7.73e-041931126GO:0015276
GeneOntologyMolecularFunctionpostsynaptic neurotransmitter receptor activity

GRIK2 GRM1 GABRA1 GABRA5

8.39e-04751124GO:0098960
GeneOntologyMolecularFunctionligand-gated channel activity

GRIK2 ANO10 RYR3 TRPM5 GABRA1 GABRA5

8.60e-041971126GO:0022834
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC26A2 PIEZO1 PKD1L1 GRIK2 ANO10 SLC7A11 SLC25A37 RYR3 PIEZO2 TRPM5 SCN2A SCN3A SCN9A LRRC8B GABRA1 GABRA5

8.91e-04118011216GO:0022857
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC26A2 PKD1L1 GRIK2 ANO10 SLC25A37 RYR3 TRPM5 SCN2A SCN3A SCN9A GABRA1 GABRA5

1.12e-0375811212GO:0015318
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH7 DNAH9 DNAH11

1.16e-03371123GO:0045505
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

PIEZO1 PKD1L1 GRIK2 ANO10 SLC25A37 RYR3 PIEZO2 TRPM5 SCN2A SCN3A SCN9A

1.27e-0366411211GO:0008324
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

SLC26A2 ANO10 LRRC8B GABRA1 GABRA5

1.62e-031511125GO:0008509
GeneOntologyMolecularFunctionbenzodiazepine receptor activity

GABRA1 GABRA5

1.66e-03111122GO:0008503
GeneOntologyMolecularFunctioncalmodulin binding

ACE GEM RYR3 SCN2A SCN3A MYH15

1.90e-032301126GO:0005516
GeneOntologyMolecularFunctiontau protein binding

MARK1 MARK3 MARK2

2.19e-03461123GO:0048156
GeneOntologyMolecularFunctionneurotransmitter receptor activity

GRIK2 GRM1 GABRA1 GABRA5

2.43e-031001124GO:0030594
GeneOntologyMolecularFunctionmonoatomic anion channel activity

ANO10 LRRC8B GABRA1 GABRA5

2.71e-031031124GO:0005253
GeneOntologyMolecularFunctionligand-gated monoatomic anion channel activity

ANO10 GABRA1 GABRA5

2.78e-03501123GO:0099095
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

GRIK2 TRPM5 SCN2A SCN3A SCN9A

2.79e-031711125GO:0015081
GeneOntologyMolecularFunctioncaspase binding

RIOK3 CTSG

3.55e-03161122GO:0089720
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

GRIK2 GABRA1 GABRA5

4.03e-03571123GO:1904315
GeneOntologyMolecularFunctionadenylate cyclase activity

ADCY10 NPR1

4.50e-03181122GO:0004016
GeneOntologyMolecularFunctionGABA-gated chloride ion channel activity

GABRA1 GABRA5

4.50e-03181122GO:0022851
GeneOntologyMolecularFunctionmechanosensitive monoatomic ion channel activity

PIEZO1 PIEZO2

4.50e-03181122GO:0008381
GeneOntologyMolecularFunctionneurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

GRIK2 GABRA1 GABRA5

4.66e-03601123GO:0099529
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

PKD1L1 GRIK2 SLC25A37 RYR3 TRPM5 SCN2A SCN3A SCN9A

4.70e-034651128GO:0046873
GeneOntologyMolecularFunctionGABA-A receptor activity

GABRA1 GABRA5

5.01e-03191122GO:0004890
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

SLC26A2 ANO10 GABRA1 GABRA5

5.40e-031251124GO:0015108
GeneOntologyMolecularFunctiontransmitter-gated channel activity

GRIK2 GABRA1 GABRA5

5.83e-03651123GO:0022835
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity

GRIK2 GABRA1 GABRA5

5.83e-03651123GO:0022824
GeneOntologyBiologicalProcessmonoatomic ion transport

SLC26A2 PIEZO1 PKD1L1 SPG11 GRIK2 ANO10 ACE GEM SLC25A37 RYR3 GRAMD2A PIEZO2 TRPM5 TMEM168 SCN2A SCN3A SCN9A LRRC8B UTRN WNK3 GABRA1 GABRA5

4.65e-06137411322GO:0006811
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SLC26A2 PIEZO1 PKD1L1 GRIK2 ANO10 GEM SLC25A37 RYR3 PIEZO2 TRPM5 TMEM168 SCN2A SCN3A SCN9A LRRC8B UTRN WNK3 GABRA1 GABRA5

9.61e-06111511319GO:0034220
GeneOntologyBiologicalProcessregulation of membrane potential

ADCY10 CUX2 PIEZO1 LRRK2 GRIK2 GRM1 PIEZO2 NUP155 SCN2A SCN3A SCN9A GABRA1 GABRA5

1.20e-0555911313GO:0042391
GeneOntologyBiologicalProcessestablishment of protein localization to organelle

ADCY10 TMEM126A FAM53A LRRK2 PEX6 SPG11 VPS25 NUP155 MKLN1 DKC1 MACF1 NUP188

2.59e-0551511312GO:0072594
GeneOntologyBiologicalProcessintracellular protein transport

TMEM30B FAM53A LRRK2 BARD1 PEX6 SPG11 VPS25 AP1S1 NUP155 STRADA EHD1 AP1S2 NUP188 HERC2

5.32e-0574011314GO:0006886
GeneOntologyBiologicalProcessmulticellular organismal response to stress

GRIK2 BRINP1 SCN3A NR2E1 SCN9A GABRA5

6.83e-051261136GO:0033555
GeneOntologyBiologicalProcesssynapse organization

COL4A1 CUX2 PRMT8 MARK1 LRRK2 SPG11 PPFIA3 SLC7A11 MARK2 RAPGEF2 MDGA1 GABRA1 GABRA5

9.70e-0568511313GO:0050808
GeneOntologyBiologicalProcessbehavior

CUX2 LRRK2 SPG11 GRIK2 BRINP1 GRM1 ACE SLC7A11 SCN2A SCN3A NR2E1 SCN9A AP1S2 DNAH11 GABRA5

1.05e-0489111315GO:0007610
GeneOntologyBiologicalProcesssodium ion transmembrane transport

TRPM5 TMEM168 SCN2A SCN3A SCN9A UTRN WNK3

1.50e-042081137GO:0035725
GeneOntologyBiologicalProcesscardiac muscle cell contraction

ADCY10 NUP155 SCN2A SCN3A SCN9A

1.60e-04931135GO:0086003
GeneOntologyBiologicalProcessmonoatomic cation transport

PIEZO1 PKD1L1 SPG11 ANO10 ACE GEM SLC25A37 RYR3 GRAMD2A PIEZO2 TRPM5 TMEM168 SCN2A SCN3A SCN9A UTRN WNK3

1.84e-04115711317GO:0006812
GeneOntologyBiologicalProcesscell junction organization

COL4A1 CUX2 PRMT8 MARK1 LRRK2 SPG11 PPFIA3 ACE SLC7A11 MACF1 MARK2 RAPGEF2 MDGA1 GABRA1 GABRA5

2.77e-0497411315GO:0034330
GeneOntologyBiologicalProcessbehavioral fear response

GRIK2 BRINP1 NR2E1 GABRA5

2.88e-04581134GO:0001662
GeneOntologyBiologicalProcessprotein localization to organelle

ADCY10 TMEM126A MARK3 FAM53A LRRK2 BARD1 PEX6 SPG11 VPS25 NUP155 EHD1 MKLN1 DKC1 MACF1 NUP188 DNAH11

2.96e-04109111316GO:0033365
GeneOntologyBiologicalProcessbehavioral defense response

GRIK2 BRINP1 NR2E1 GABRA5

3.08e-04591134GO:0002209
GeneOntologyBiologicalProcessepithelial cilium movement involved in extracellular fluid movement

ADCY10 KIF27 DNAH9 DNAH11

3.08e-04591134GO:0003351
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

NUP155 SCN2A SCN3A SCN9A

3.73e-04621134GO:0086002
GeneOntologyBiologicalProcessextracellular transport

ADCY10 KIF27 DNAH9 DNAH11

3.73e-04621134GO:0006858
GeneOntologyBiologicalProcesstransmission of nerve impulse

OTOA GRIK2 SCN2A SCN3A SCN9A

3.80e-041121135GO:0019226
GeneOntologyBiologicalProcessdetection of external stimulus

NR2E3 PIEZO1 PKD1L1 GRIK2 PIEZO2 SCN9A

3.84e-041731136GO:0009581
GeneOntologyBiologicalProcessneuronal action potential

GRIK2 SCN2A SCN3A SCN9A

3.97e-04631134GO:0019228
GeneOntologyBiologicalProcessdetection of abiotic stimulus

NR2E3 PIEZO1 PKD1L1 GRIK2 PIEZO2 SCN9A

4.09e-041751136GO:0009582
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

SLC26A2 PKD1L1 ANO10 GEM SLC25A37 RYR3 TRPM5 TMEM168 SCN2A SCN3A SCN9A UTRN WNK3 GABRA1 GABRA5

4.37e-04101711315GO:0098660
GeneOntologyBiologicalProcessfear response

GRIK2 BRINP1 NR2E1 GABRA5

4.74e-04661134GO:0042596
GeneOntologyBiologicalProcessregulation of postsynaptic membrane potential

CUX2 LRRK2 GRIK2 GRM1 GABRA1 GABRA5

4.74e-041801136GO:0060078
GeneOntologyBiologicalProcessnegative regulation of nervous system development

SOX11 BRINP1 CASZ1 NR2E1 RAPGEF2 MDGA1

5.33e-041841136GO:0051961
GeneOntologyBiologicalProcessregulation of neurogenesis

ADCY10 SOX11 CUX2 BRINP1 ACE CASZ1 NR2E1 MACF1 RAPGEF2 CUX1

5.38e-0451511310GO:0050767
GeneOntologyBiologicalProcessregulation of neuron projection development

ADCY10 CUX2 MARK1 LRRK2 PTPN9 EHD1 NR2E1 MACF1 MARK2 RAPGEF2 CUX1

5.41e-0461211311GO:0010975
GeneOntologyBiologicalProcessmembrane depolarization

ADCY10 LRRK2 SCN2A SCN3A SCN9A

5.42e-041211135GO:0051899
GeneOntologyBiologicalProcesscamera-type eye development

COL4A1 SOX11 LPCAT1 NR2E3 SLC7A11 CASZ1 ADAMTS9 NR2E1 CRYBG3

5.65e-044261139GO:0043010
GeneOntologyBiologicalProcessinhibitory synapse assembly

MDGA1 GABRA1 GABRA5

5.84e-04301133GO:1904862
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

PIEZO1 PKD1L1 ANO10 GEM SLC25A37 RYR3 PIEZO2 TRPM5 TMEM168 SCN2A SCN3A SCN9A UTRN WNK3

6.37e-0494211314GO:0098655
GeneOntologyBiologicalProcessregulation of nervous system development

ADCY10 SOX11 CUX2 BRINP1 ACE CASZ1 NR2E1 MACF1 RAPGEF2 MDGA1 CUX1

6.43e-0462511311GO:0051960
GeneOntologyBiologicalProcesssensory organ development

COL4A1 SOX11 LPCAT1 NR2E3 SLC7A11 CASZ1 ADAMTS9 NR2E1 CRYBG3 USH2A CUX1 GABRA5

6.65e-0473011312GO:0007423
GeneOntologyBiologicalProcessactin-mediated cell contraction

ADCY10 NUP155 SCN2A SCN3A SCN9A

6.75e-041271135GO:0070252
GeneOntologyCellularComponentcell projection membrane

SLC26A2 PIEZO1 PKD1L1 ACE SLC7A11 EHD1 MACF1 USH2A UTRN WWC1 GABRA1 GABRA5

3.83e-0643111312GO:0031253
GeneOntologyCellularComponentsodium channel complex

GRIK2 SCN2A SCN3A SCN9A

1.73e-05291134GO:0034706
GeneOntologyCellularComponentmonoatomic ion channel complex

PKD1L1 GRIK2 RYR3 TRPM5 SCN2A SCN3A SCN9A LRRC8B GABRA1 GABRA5

3.95e-0537811310GO:0034702
GeneOntologyCellularComponentdendrite

ADCY10 MARK1 MARK3 LRRK2 SPG11 GRIK2 BRINP1 MAGEE1 GRM1 TRPM5 BRINP2 MARK2 MDGA1 GABRA1 GABRA5

5.95e-0585811315GO:0030425
GeneOntologyCellularComponentdendritic tree

ADCY10 MARK1 MARK3 LRRK2 SPG11 GRIK2 BRINP1 MAGEE1 GRM1 TRPM5 BRINP2 MARK2 MDGA1 GABRA1 GABRA5

6.11e-0586011315GO:0097447
GeneOntologyCellularComponentnuclear pore inner ring

NUP155 NUP188

8.66e-0531132GO:0044611
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN2A SCN3A SCN9A

9.90e-05171133GO:0001518
GeneOntologyCellularComponentsomatodendritic compartment

ADCY10 MARK1 MARK3 LRRK2 SPG11 GRIK2 BRINP1 MAGEE1 GRM1 TRPM5 SCN3A BRINP2 MARK2 RAPGEF2 MDGA1 USH2A GABRA1 GABRA5

1.01e-04122811318GO:0036477
GeneOntologyCellularComponenttransporter complex

TMEM30B PKD1L1 GRIK2 RYR3 TRPM5 SCN2A SCN3A SCN9A LRRC8B GABRA1 GABRA5

1.95e-0455011311GO:1990351
GeneOntologyCellularComponenttransmembrane transporter complex

PKD1L1 GRIK2 RYR3 TRPM5 SCN2A SCN3A SCN9A LRRC8B GABRA1 GABRA5

5.47e-0452311310GO:1902495
GeneOntologyCellularComponentcytoplasmic region

EFCAB6 LRRK2 GRIK2 PPFIA3 DNAH7 MARK2 DNAH9 DNAH11

7.62e-043601138GO:0099568
GeneOntologyCellularComponentleading edge membrane

PIEZO1 MACF1 USH2A WWC1 GABRA1 GABRA5

9.91e-042101136GO:0031256
GeneOntologyCellularComponentcation channel complex

PKD1L1 GRIK2 RYR3 SCN2A SCN3A SCN9A

1.76e-032351136GO:0034703
GeneOntologyCellularComponentterminal bouton

LRRK2 GRIK2 AP1S1 USH2A

1.83e-03961134GO:0043195
GeneOntologyCellularComponentAP-1 adaptor complex

AP1S1 AP1S2

1.85e-03121132GO:0030121
HumanPhenoDysgenesis of the hippocampus

SCN2A SCN9A MACF1 GABRA1

1.61e-0516524HP:0025101
HumanPhenoFocal impaired awareness seizure

CEP85L GRIK2 STRADA SCN2A SCN3A SCN9A MACF1 GABRA1

3.39e-05126528HP:0002384
HumanPhenoPhotosensitive myoclonic seizure

SCN2A SCN9A GABRA1

5.42e-058523HP:0001327
HumanPhenoCyanotic episode

SCN2A SCN9A GABRA1

5.42e-058523HP:0200048
HumanPhenoPoor fine motor coordination

PIEZO2 SCN2A SCN9A HERC2 CUX1 GABRA1

6.18e-0569526HP:0007010
HumanPhenoTibial torsion

SLC26A2 SCN2A SCN9A GABRA1

7.41e-0523524HP:0100694
HumanPhenoAtypical absence seizure

CUX2 CEP85L SCN2A SCN9A GABRA1

9.10e-0546525HP:0007270
HumanPhenoFocal hemiclonic seizure

CUX2 SCN2A SCN9A GABRA1

1.04e-0425524HP:0006813
HumanPhenoAbnormal hippocampus morphology

CEP85L SCN2A SCN9A MACF1 GABRA1

1.12e-0448525HP:0025100
HumanPhenoAbnormal morphology of the limbic system

CEP85L SCN2A SCN9A MACF1 GABRA1

1.24e-0449525HP:0007343
HumanPhenoClonic seizure

CUX2 GRIK2 SCN2A SCN3A SCN9A GABRA1

1.52e-0481526HP:0020221
HumanPhenoLimited neck range of motion

SCN2A SCN9A GABRA1

1.56e-0411523HP:0000466
HumanPhenoPoor motor coordination

PIEZO2 SCN2A SCN9A HERC2 CUX1 GABRA1

1.99e-0485526HP:0002275
HumanPhenoEpilepsia partialis continua

SCN2A SCN9A GABRA1

2.07e-0412523HP:0012847
HumanPhenoProgressive gait ataxia

ANO10 SCN2A SCN9A GABRA1

2.18e-0430524HP:0007240
HumanPhenoProgressive ataxia

ANO10 SCN2A SCN9A GABRA1

2.18e-0430524HP:0001329
HumanPhenoCongenitally corrected transposition of the great arteries

PKD1L1 DNAH9

3.05e-043522HP:0011540
HumanPhenoObsessive-compulsive trait

SCN2A SCN9A ASCC3 GABRA1

3.18e-0433524HP:0008770
HumanPhenoAtonic seizure

CUX2 CEP85L GRIK2 SCN2A SCN9A GABRA1

3.45e-0494526HP:0010819
DomainMARK/par1

MARK1 MARK3 MARK2

8.36e-0741123IPR033624
DomainKA1

MARK1 MARK3 MARK2

2.08e-0651123PF02149
DomainKA1_dom

MARK1 MARK3 MARK2

2.08e-0651123IPR001772
DomainKA1

MARK1 MARK3 MARK2

2.08e-0651123PS50032
Domain-

MARK1 MARK3 MARK2

2.08e-06511233.30.310.80
DomainNa_trans_cytopl

SCN2A SCN3A SCN9A

4.14e-0661123PF11933
DomainNa_trans_cytopl

SCN2A SCN3A SCN9A

4.14e-0661123IPR024583
DomainCUT

CUX2 ONECUT1 CUX1

7.22e-0671123PS51042
DomainKA1/Ssp2_C

MARK1 MARK3 MARK2

7.22e-0671123IPR028375
DomainCUT

CUX2 ONECUT1 CUX1

7.22e-0671123PF02376
DomainCUT_dom

CUX2 ONECUT1 CUX1

7.22e-0671123IPR003350
DomainCUT

CUX2 ONECUT1 CUX1

7.22e-0671123SM01109
DomainNa_channel_asu

SCN2A SCN3A SCN9A

2.44e-05101123IPR001696
DomainNa_trans_assoc

SCN2A SCN3A SCN9A

2.44e-05101123IPR010526
DomainNa_trans_assoc

SCN2A SCN3A SCN9A

2.44e-05101123PF06512
DomainPIEZO

PIEZO1 PIEZO2

3.56e-0521122PF15917
DomainPiezo

PIEZO1 PIEZO2

3.56e-0521122IPR027272
DomainPiezo_RRas_bdg

PIEZO1 PIEZO2

3.56e-0521122PF12166
DomainPiezo_RRas-bd_dom

PIEZO1 PIEZO2

3.56e-0521122IPR031334
DomainPiezo_dom

PIEZO1 PIEZO2

3.56e-0521122IPR031805
DomainDynein_heavy_chain_D4_dom

DNAH7 DNAH9 DNAH11

7.28e-05141123IPR024317
DomainDynein_HC_stalk

DNAH7 DNAH9 DNAH11

7.28e-05141123IPR024743
DomainDynein_heavy_dom-2

DNAH7 DNAH9 DNAH11

7.28e-05141123IPR013602
DomainDHC_N2

DNAH7 DNAH9 DNAH11

7.28e-05141123PF08393
DomainMT

DNAH7 DNAH9 DNAH11

7.28e-05141123PF12777
DomainAAA_8

DNAH7 DNAH9 DNAH11

7.28e-05141123PF12780
DomainDHC_fam

DNAH7 DNAH9 DNAH11

9.06e-05151123IPR026983
DomainDynein_heavy

DNAH7 DNAH9 DNAH11

9.06e-05151123PF03028
DomainDynein_heavy_dom

DNAH7 DNAH9 DNAH11

9.06e-05151123IPR004273
DomainPHOSPHORYLASE

PYGB PYGL

1.07e-0431122PS00102
DomainBRINP

BRINP1 BRINP2

1.07e-0431122IPR033237
DomainGlycg_phsphrylas

PYGB PYGL

1.07e-0431122IPR011833
DomainGlyco_trans_35

PYGB PYGL

1.07e-0431122IPR000811
DomainPhosphorylase

PYGB PYGL

1.07e-0431122PF00343
DomainEF-hand-dom_pair

LPCAT1 EFCAB6 RYR3 SCN3A EHD1 SCN9A MACF1 UTRN

3.37e-042871128IPR011992
DomainGABAAa_rcpt

GABRA1 GABRA5

5.26e-0461122IPR001390
Domain-

CUX2 ONECUT1 CUX1

5.53e-042711231.10.260.40
DomainIon_trans_dom

RYR3 TRPM5 SCN2A SCN3A SCN9A

6.19e-041141125IPR005821
DomainIon_trans

RYR3 TRPM5 SCN2A SCN3A SCN9A

6.19e-041141125PF00520
DomainLambda_DNA-bd_dom

CUX2 ONECUT1 CUX1

6.85e-04291123IPR010982
DomainAP_complex_ssu

AP1S1 AP1S2

7.34e-0471122IPR016635
DomainUBA

MARK1 MARK3 MARK2

7.57e-04301123SM00165
DomainDHC_N1

DNAH9 DNAH11

9.75e-0481122PF08385
DomainDynein_heavy_dom-1

DNAH9 DNAH11

9.75e-0481122IPR013594
DomainCLAT_ADAPTOR_S

AP1S1 AP1S2

1.25e-0391122PS00989
DomainUBA

MARK1 MARK3 MARK2

1.30e-03361123PF00627
DomainANF_lig-bd_rcpt

NPR1 GRIK2 GRM1

1.41e-03371123IPR001828
DomainANF_receptor

NPR1 GRIK2 GRM1

1.41e-03371123PF01094
DomainMAC_perforin

BRINP1 BRINP2

1.55e-03101122IPR001862
DomainRetinoid-X_rcpt/HNF4

NR2E3 NR2E1

1.55e-03101122IPR000003
DomainPeripla_BP_I

NPR1 GRIK2 GRM1

1.64e-03391123IPR028082
DomainAAA

PEX6 DNAH7 ASCC3 DNAH9 DNAH11

1.76e-031441125SM00382
DomainAAA+_ATPase

PEX6 DNAH7 ASCC3 DNAH9 DNAH11

1.76e-031441125IPR003593
DomainMACPF

BRINP1 BRINP2

1.89e-03111122PF01823
DomainClathrin_sm-chain_CS

AP1S1 AP1S2

2.26e-03121122IPR000804
DomainMACPF

BRINP1 BRINP2

2.26e-03121122IPR020864
DomainMACPF

BRINP1 BRINP2

2.26e-03121122SM00457
DomainUBA

MARK1 MARK3 MARK2

2.32e-03441123IPR015940
DomainIQ

SCN2A SCN3A SCN9A MYH15

2.37e-03931124PS50096
DomainEF_hand_dom

LPCAT1 EFCAB6 DNAH7 RYR3 EHD1 MACF1

2.76e-032321126IPR002048
DomainUBA

MARK1 MARK3 MARK2

2.81e-03471123PS50030
DomainATPase_dyneun-rel_AAA

DNAH9 DNAH11

3.09e-03141122IPR011704
DomainAAA_5

DNAH9 DNAH11

3.09e-03141122PF07728
DomainAP_mu_sigma_su

AP1S1 AP1S2

4.05e-03161122IPR022775
DomainAcyltransferase

LPCAT1 GPAM

4.05e-03161122PF01553
DomainClat_adaptor_s

AP1S1 AP1S2

4.05e-03161122PF01217
DomainPlsC

LPCAT1 GPAM

4.57e-03171122SM00563
DomainPlipid/glycerol_acylTrfase

LPCAT1 GPAM

4.57e-03171122IPR002123
DomainChannel_four-helix_dom

SCN2A SCN3A SCN9A

4.85e-03571123IPR027359
Domain-

SCN2A SCN3A SCN9A

4.85e-035711231.20.120.350
DomainP-loop_NTPase

ADCY10 CHST5 KIF27 LRRK2 PEX6 DNAH7 GEM EHD1 MYH15 ASCC3 DNAH9 DNAH11

4.88e-0384811212IPR027417
Domain-

LPCAT1 EFCAB6 RYR3 EHD1 MACF1 UTRN

4.90e-0326111261.10.238.10
DomainZF_ZZ_2

HERC2 UTRN

5.12e-03181122PS50135
DomainZF_ZZ_1

HERC2 UTRN

5.12e-03181122PS01357
Domain-

ADCY10 NPR1

5.12e-031811223.30.70.1230
DomainZZ

HERC2 UTRN

5.12e-03181122PF00569
DomainNucleotide_cyclase

ADCY10 NPR1

5.12e-03181122IPR029787
DomainKinase-like_dom

NPR1 MARK1 MARK3 LRRK2 RIOK3 STRADA MACF1 MARK2 WNK3

5.34e-035421129IPR011009
DomainGuanylate_cyc

ADCY10 NPR1

5.70e-03191122PF00211
DomainGUANYLATE_CYCLASE_2

ADCY10 NPR1

5.70e-03191122PS50125
DomainA/G_cyclase

ADCY10 NPR1

5.70e-03191122IPR001054
DomainZnf_ZZ

HERC2 UTRN

5.70e-03191122IPR000433
DomainGUANYLATE_CYCLASE_1

ADCY10 NPR1

5.70e-03191122PS00452
DomainCYCc

ADCY10 NPR1

5.70e-03191122SM00044
DomainZnF_ZZ

HERC2 UTRN

5.70e-03191122SM00291
PathwayREACTOME_SENSORY_PERCEPTION_OF_TASTE

GRM1 TRPM5 SCN2A SCN3A SCN9A

1.31e-0547925M42524
Pubmed

Voltage-gated sodium channels in taste bud cells.

SCN2A SCN3A SCN9A

3.34e-083113319284629
Pubmed

Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.

MARK1 MARK3 BRINP1 STRADA MARK2 RAPGEF2

9.56e-0868113614676191
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN2A SCN3A SCN9A

3.32e-07511338812438
Pubmed

Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's disease.

MARK1 MARK3 MARK2

6.63e-076113323666762
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN2A SCN3A SCN9A

6.63e-076113323652591
Pubmed

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.

PRMT8 MARK3 BRINP1 GRM1 HSPA12A EHD1 SCN9A MARK2 GABRA1 GABRA5

8.78e-074051131038187761
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

CEP85L MARK1 MARK3 RBM42 BARD1 PFAS NUP155 DKC1 PYGL NUP188 MARK2 HERC2 ASCC3 GCN1 UTRN

9.54e-0710051131519615732
Pubmed

IgSF molecule MDGA1 is involved in radial migration and positioning of a subset of cortical upper-layer neurons.

CUX2 MDGA1 CUX1

1.85e-068113321104742
Pubmed

Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions.

MARK1 MARK3 MARK2

1.85e-068113322298430
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN2A SCN3A SCN9A

2.77e-069113316382098
Pubmed

Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.

LPCAT1 MARK1 MARK3 ANO10 SLC7A11 NUP155 EHD1 MACF1 MARK2 CUX1

3.13e-064671131030194290
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN2A SCN3A SCN9A

9.33e-0613113315123669
Pubmed

Cux1 and Cux2 selectively target basal and apical dendritic compartments of layer II-III cortical neurons.

CUX2 CUX1

1.05e-052113225059644
Pubmed

Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.

SCN2A SCN3A

1.05e-052113220346423
Pubmed

[Feeling the pressure? Identification of two proteins activated by mechanical forces].

PIEZO1 PIEZO2

1.05e-052113221299953
Pubmed

Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.

SCN2A SCN3A

1.05e-052113211245985
Pubmed

Functional and behavioral effects of de novo mutations in calcium-related genes in patients with bipolar disorder.

EHD1 MACF1

1.05e-052113234100076
Pubmed

Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development.

PIEZO1 PIEZO2

1.05e-052113238395992
Pubmed

Differential expression of PIEZO1 and PIEZO2 mechanosensitive channels in ocular tissues implicates diverse functional roles.

PIEZO1 PIEZO2

1.05e-052113237820892
Pubmed

Mechanisms of mechanotransduction and physiological roles of PIEZO channels.

PIEZO1 PIEZO2

1.05e-052113239251883
Pubmed

CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate.

CUX2 CUX1

1.05e-052113235581205
Pubmed

Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament.

PIEZO1 PIEZO2

1.05e-052113237975162
Pubmed

Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.

SCN2A SCN3A

1.05e-052113223016767
Pubmed

Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels.

PIEZO1 PIEZO2

1.05e-052113228636944
Pubmed

Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.

SCN2A SCN3A

1.05e-052113227153334
Pubmed

Formation of GABAA receptor complexes containing α1 and α5 subunits is paralleling a multiple T-maze learning task in mice.

GABRA1 GABRA5

1.05e-052113227155990
Pubmed

Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.

SCN3A SCN9A

1.05e-052113225172946
Pubmed

The LisH motif of muskelin is crucial for oligomerization and governs intracellular localization.

MKLN1 GABRA1

1.05e-052113225579817
Pubmed

Piezo channels: from structure to function.

PIEZO1 PIEZO2

1.05e-052113225037583
Pubmed

Altered inhibitory synapses in de novo GABRA5 and GABRA1 mutations associated with early onset epileptic encephalopathies.

GABRA1 GABRA5

1.05e-052113231056671
Pubmed

Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2.

MARK1 MARK2

1.05e-052113216803889
Pubmed

The role of PIEZO ion channels in the musculoskeletal system.

PIEZO1 PIEZO2

1.05e-052113236717101
Pubmed

Cross Talk Between GH-Regulated Transcription Factors HNF6 and CUX2 in Adult Mouse Liver.

CUX2 ONECUT1

1.05e-052113226218442
Pubmed

A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel.

PIEZO1 PIEZO2

1.05e-052113232142647
Pubmed

Functional roles for PIEZO1 and PIEZO2 in urothelial mechanotransduction and lower urinary tract interoception.

PIEZO1 PIEZO2

1.05e-052113234464353
Pubmed

Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis.

MARK3 MARK2

1.05e-052113220733003
Pubmed

Neutrophil cathepsin G promotes prothrombinase and fibrin formation under flow conditions by activating fibrinogen-adherent platelets.

F10 CTSG

1.05e-052113212524437
Pubmed

Cux-1 and Cux-2 control the development of Reelin expressing cortical interneurons.

CUX2 CUX1

1.05e-052113218327765
Pubmed

A unique variant of a homeobox gene related to Drosophila cut is expressed in mouse testis.

CUX2 CUX1

1.05e-05211328879483
Pubmed

The alpha5(H105R) mutation impairs alpha5 selective binding properties by altered positioning of the alpha5 subunit in GABAA receptors containing two distinct types of alpha subunits.

GABRA1 GABRA5

1.05e-052113219457072
Pubmed

Piezo proteins: incidence and abundance in the enteric nervous system. Is there a link with mechanosensitivity?

PIEZO1 PIEZO2

1.05e-052113230324494
Pubmed

Expression of a cut-related homeobox gene in developing and polycystic mouse kidney.

CUX2 CUX1

1.05e-05211328840273
Pubmed

A novel form of low-frequency hippocampal mossy fiber plasticity induced by bimodal mGlu1 receptor signaling.

GRIK2 GRM1

1.05e-052113222114260
Pubmed

Mechanosensitive channels: in touch with Piezo.

PIEZO1 PIEZO2

1.05e-052113221056836
Pubmed

Loss of stretch-activated channels, PIEZOs, accelerates non-small cell lung cancer progression and cell migration.

PIEZO1 PIEZO2

1.05e-052113230745454
Pubmed

Astrocytes in the optic nerve head express putative mechanosensitive channels.

PIEZO1 PIEZO2

1.05e-052113226236150
Pubmed

Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels.

PIEZO1 PIEZO2

1.05e-052113227743844
Pubmed

Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause's Corpuscles.

PIEZO1 PIEZO2

1.05e-052113238928429
Pubmed

A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels.

PIEZO1 PIEZO2

1.05e-052113230628892
Pubmed

Piezo1 ion channel pore properties are dictated by C-terminal region.

PIEZO1 PIEZO2

1.05e-052113226008989
Pubmed

Cux1 Enables Interhemispheric Connections of Layer II/III Neurons by Regulating Kv1-Dependent Firing.

CUX2 CUX1

1.05e-052113226804994
Pubmed

Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels.

PIEZO1 PIEZO2

1.05e-052113220813920
Pubmed

Role of GABAA alpha5-containing receptors in ethanol reward: the effects of targeted gene deletion, and a selective inverse agonist.

GABRA1 GABRA5

1.05e-052113216253225
Pubmed

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.

COL4A1 LPCAT1 NR2E3 ONECUT1 NR2E1 MACF1 USH2A

1.17e-05233113732290105
Pubmed

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

MARK1 STRADA MARK2

1.48e-0515113314976552
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

LPCAT1 ACTR8 ADNP2 PEX6 PPFIA3 FMNL2 MACF1 LRRC8B NUP188 CRYBG3 ASCC3 RAPGEF2 ANKS3 WWC1

1.62e-0511161131431753913
Pubmed

Diagnostic outcomes for genetic testing of 70 genes in 8565 patients with epilepsy and neurodevelopmental disorders.

SCN2A GABRA1

3.13e-053113229655203
Pubmed

Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family.

BRINP1 BRINP2

3.13e-053113215193423
Pubmed

The 8th and 9th tandem spectrin-like repeats of utrophin cooperatively form a functional unit to interact with polarity-regulating kinase PAR-1b.

MARK2 UTRN

3.13e-053113219945424
Pubmed

Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+).

SCN3A SCN9A

3.13e-053113233895391
Pubmed

SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.

SCN2A SCN3A

3.13e-053113223859570
Pubmed

Long-range disruption of gene expression by a selectable marker cassette.

GZMH CTSG

3.13e-05311328917549
Pubmed

Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons.

PIEZO1 PIEZO2

3.13e-053113229521261
Pubmed

The genomic and clinical landscape of fetal akinesia.

RYR3 GCN1

3.13e-053113231680123
Pubmed

Labeling PIEZO2 activity in the peripheral nervous system.

PIEZO1 PIEZO2

3.13e-053113237321223
Pubmed

Analysis of the expression and function of BRINP family genes during neuronal differentiation in mouse embryonic stem cell-derived neural stem cells.

BRINP1 BRINP2

3.13e-053113220025061
Pubmed

Sodium channels SCN1A, SCN2A and SCN3A in familial autism.

SCN2A SCN3A

3.13e-053113212610651
Pubmed

Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia.

SCN3A SCN9A

3.13e-053113219699781
Pubmed

Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.

SCN2A SCN3A

3.13e-053113218784617
Pubmed

Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates ACE and AT1 receptor gene expression and signaling: role in cardiac hypertrophy.

NPR1 ACE

3.13e-053113217566078
Pubmed

Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.

SCN2A SCN3A

3.13e-053113217544618
Pubmed

Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids.

MARK1 MARK3

3.13e-053113221145462
Pubmed

Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice.

PIEZO1 PIEZO2

3.13e-053113230726728
Pubmed

Exploring Piezo1, Piezo2, and TMEM150C in human brain tissues and their correlation with brain biomechanical characteristics.

PIEZO1 PIEZO2

3.13e-053113238124148
Pubmed

Multimodal Analysis of STRADA Function in Brain Development.

STRADA CUX1

3.13e-053113232457579
Pubmed

Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells.

SCN2A SCN3A

3.13e-053113216052353
Pubmed

PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex.

PIEZO1 PIEZO2

3.13e-053113230361375
Pubmed

Piezo1, a mechanically activated ion channel, is required for vascular development in mice.

PIEZO1 PIEZO2

3.13e-053113224958852
Pubmed

Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.

SCN2A SCN3A

3.13e-053113214973256
Pubmed

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption.

MARK1 MARK2

3.13e-05311329108484
Pubmed

PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.

MARK3 MARK2

3.13e-053113211433294
Pubmed

Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth.

PIEZO1 PIEZO2

3.13e-053113235650194
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MARK1 PFAS GPAM FMNL2 CASZ1 RGL1 ADAMTS9 TLR1 MACF1

3.48e-05493113915368895
Pubmed

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.

MARK1 MARK3 MARK2

3.66e-0520113318227155
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

COL4A1 PIEZO1 PKD1L1 LRRK2 ANO10 PIEZO2 TMEM168 CPXM1 NUP188 HERC2 ASCC3 RAPGEF2 UTRN RUBCN

4.10e-0512151131415146197
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

PFAS NUP155 PYGB MACF1 PYGL NUP188 HERC2 ASCC3 GCN1 UTRN

5.57e-056531131022586326
Pubmed

DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex.

SOX11 CUX2 CUX1

5.64e-0523113330329130
Pubmed

Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.

NR2E3 ADAM12 GRAMD2A PIEZO2

6.14e-0565113423319000
Pubmed

Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene.

GZMH CTSG

6.25e-05411328453108
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN2A SCN3A

6.25e-054113217537961
Pubmed

Mechanosensory hair cells express two molecularly distinct mechanotransduction channels.

PIEZO1 PIEZO2

6.25e-054113227893727
Pubmed

Expression of FAP, ADAM12, WISP1, and SOX11 is heterogeneous in aggressive fibromatosis and spatially relates to the histologic features of tumor activity.

SOX11 ADAM12

6.25e-054113224402778
Pubmed

AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast.

AP1S1 AP1S2

6.25e-05411322040623
Pubmed

EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole.

EHD1 HERC2

6.25e-054113237074924
Pubmed

AP-1/σ1A and AP-1/σ1B adaptor-proteins differentially regulate neuronal early endosome maturation via the Rab5/Vps34-pathway.

AP1S1 AP1S2

6.25e-054113227411398
Pubmed

Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity.

PIEZO1 PIEZO2

6.25e-054113236563677
Pubmed

Polymorphisms of renin-angiotensin system and natriuretic peptide receptor A genes in patients of Greek origin with a history of myocardial infarction.

NPR1 ACE

6.25e-054113220529973
Pubmed

σ1B adaptin regulates adipogenesis by mediating the sorting of sortilin in adipose tissue.

AP1S1 AP1S2

6.25e-054113224928897
Pubmed

AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory.

AP1S1 AP1S2

6.25e-054113220203623
Pubmed

Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.

SCN2A SCN3A

6.25e-054113235801810
InteractionMARK1 interactions

CEP85L MARK1 MARK3 LRRK2 MARK2 UTRN

3.69e-06741136int:MARK1
InteractionFUCA1 interactions

MARK1 MARK3 BARD1 MARK2

1.49e-05271134int:FUCA1
Cytoband6q24

GRM1 UTRN

1.64e-04811226q24
Cytoband2q24

SCN3A SCN9A

3.20e-041111222q24
GeneFamilySodium voltage-gated channel alpha subunits

SCN2A SCN3A SCN9A

7.41e-0698231203
GeneFamilyCUT class homeoboxes and pseudogenes

CUX2 ONECUT1 CUX1

7.41e-069823527
GeneFamilyDyneins, axonemal

DNAH7 DNAH9 DNAH11

5.84e-0517823536
GeneFamilyGlycogen phosphorylases

PYGB PYGL

6.08e-053822437
GeneFamilyEF-hand domain containing

LPCAT1 EFCAB6 DNAH7 RYR3 EHD1 MACF1

4.80e-04219826863
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

HERC2 UTRN

2.97e-031882291
GeneFamilyGamma-aminobutyric acid type A receptor subunits

GABRA1 GABRA5

3.30e-0319822563
CoexpressionFOSTER_TOLERANT_MACROPHAGE_UP

CEP85L RIOK3 PPFIA3 SLC7A11 GEM F10 SLC25A37 RGL1

5.94e-071661128M12595
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

SOX11 CEP85L MARK1 LRRK2 GRIK2 GRM1 FMNL2 CASZ1 HSPA12A PIEZO2 ST3GAL5 SCN2A SCN3A SCN9A AP1S2 MDGA1 WNK3 GABRA1

1.04e-06110611218M39071
CoexpressionFOSTER_TOLERANT_MACROPHAGE_UP

CEP85L RIOK3 PPFIA3 SLC7A11 GEM F10 SLC25A37 RGL1

1.46e-061871128MM1034
CoexpressionGSE42021_CD24INT_VS_CD24LOW_TREG_THYMUS_UP

MARK3 ONECUT1 SLC7A11 RGL1 AP1S2 ASCC3 RNF39

2.27e-051971127M9589
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OTOA SOX11 EFCAB6 GRM1 RYR3 PIEZO2 SCN2A SCN9A MYH15 USH2A DNAH9 DNAH11

4.71e-14184112122cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OTOA SOX11 EFCAB6 GRM1 RYR3 PIEZO2 SCN2A SCN9A MYH15 USH2A DNAH9 DNAH11

4.71e-1418411212ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OTOA SOX11 EFCAB6 GRM1 RYR3 PIEZO2 SCN2A SCN9A MYH15 USH2A DNAH9 DNAH11

4.71e-14184112122b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GPR143 GPAM SLC7A11 DNAH7 RYR3 HHATL RGL1 MACF1 MYH15

2.09e-092001129d0812817ef99608994193787a62d39adeb2070ca
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GPR143 GPAM SLC7A11 DNAH7 RYR3 HHATL RGL1 MACF1 MYH15

2.09e-092001129cd54ddf1919c98e84b7e4aba85b374fc8b407206
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RYR3 SCN3A SCN9A MYH15 USH2A DNAH9 DNAH11

2.42e-07169112712bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CCDC168|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CUX2 PRMT8 BARD1 BRINP1 ADAMTS9 UTRN CUX1

3.71e-071801127a407376209d80177bf7fc4200219030c83cb5f14
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CACNG5|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CUX2 PRMT8 LRRK2 BARD1 ADAM12 RYR3 CUX1

4.30e-071841127658f2e522055e88c92bc482a845c40f8f5f1a8e3
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

PRMT8 GRM1 SCN2A SCN3A SCN9A GABRA1 GABRA5

5.34e-0719011276e92c78799f34b31d098854503c796edb0dc7f80
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LPCAT1 PRMT8 LRRK2 DNAH7 C4BPA WWC1 DNAH11

5.94e-071931127bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CUX2 PRMT8 LRRK2 BRINP1 SCN2A CUX1 GABRA1

6.36e-071951127787e95fb59c40bba784544b662fac37606ae1427
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRMT8 KIF27 EFCAB6 DNAH7 HSPA12A DNAH9 DNAH11

6.81e-07197112774a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CYP4V2 GPR143 GPAM SLC7A11 DNAH7 RYR3 HHATL

7.54e-0720011277a8160e6477708f22e48c609bf8f43f3715dcb03
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Astrocyte-Astrocyte-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GPR143 GPAM DNAH7 RYR3 HHATL RGL1 MACF1

7.54e-07200112707d942803360e1a1e8e131d6e31c726dd0db1a0b
ToppCellMyeloid-Myeloid-F|Myeloid / shred on cell class and cell subclass (v4)

CYP4V2 GRM1 FMNL2 F10 SLC25A37 EHD1

2.79e-061561126d6317843ae5c5749452889e768c187a9d9e8c7fe
ToppCellCOPD-Myeloid-pDC|COPD / Disease state, Lineage and Cell class

CUX2 PFAS SLC7A11 SCN9A RAPGEF2 RUBCN

5.77e-061771126415aa023195a7f961c09529f65cdcc7bb90eaf5d
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PIEZO1 PIEZO2 SCN3A SCN9A MACF1 UTRN

5.96e-061781126ad3de3e03a401dac64431a541899445262246347
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PIEZO1 PIEZO2 SCN3A SCN9A MACF1 UTRN

6.56e-061811126e898ecb8d8f2eb2204225b7b0d665cadcd241139
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMEM30B CHST5 SLC7A11 F10 USH2A WNK3

6.56e-061811126cb17c904ab86d56dd30cac9b61acbb3b76f84ded
ToppCell-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

SLC26A2 ADAM12 PIEZO2 SCN2A CPXM1 WNK3

6.56e-061811126ef579e958f334da0f9415aa7e3d5c02c807954a6
ToppCellPND07-28-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high|PND07-28-samps / Age Group, Lineage, Cell class and subclass

COL4A1 SOX11 NPR1 ACE CASZ1 PIEZO2

6.56e-0618111269cd5e5c285c2b628db9d59709af053defd7c0aff
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CUX2 BRINP1 DNAH7 SLC25A37 SCN9A CUX1

7.20e-0618411266475a43201b136dcc9b113d2ca4cfa154ed9d65d
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

PKD1L1 ACE ADAM12 GEM NUP155 ANKS3

7.43e-061851126e06a784a297f357f3f8e761c24fa70722048ab42
ToppCellFetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL4A1 MARK1 FMNL2 GEM RYR3 ADAMTS9

7.43e-061851126e58a009aaf342be019a909747b1895d5987d4daf
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CCDC168|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CUX2 PRMT8 LRRK2 BRINP1 UTRN CUX1

7.43e-0618511265a0340c25196453f19e424d346efbf66d2c53ac3
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|World / Sample and Cell Type and Tumor Cluster (all cells)

COL4A1 MARK1 ADAM12 GEM PIEZO2 ADAMTS9

7.66e-061861126cb1fc4b9140666b43415e21c9b434dc9b144e9d0
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRRK2 DNAH7 ADAMTS9 MKLN1 WWC1 DNAH11

7.66e-061861126f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PIEZO1 PIEZO2 SCN3A SCN9A MACF1 UTRN

7.66e-06186112620340a5b5cc7f07386498a4ef937d6fbc9e347c4
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EFCAB6 LRRK2 DNAH7 ADAMTS9 MKLN1 WWC1

7.90e-061871126c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellPND07-28-samps-Endothelial|PND07-28-samps / Age Group, Lineage, Cell class and subclass

COL4A1 SOX11 NPR1 ACE CASZ1 PIEZO2

8.39e-061891126eb2f8c8a90e5e9f6697a2d13274c94f40e1973e4
ToppCellPND07-28-samps-Endothelial-Postnatal_endothelial|PND07-28-samps / Age Group, Lineage, Cell class and subclass

COL4A1 SOX11 NPR1 ACE CASZ1 PIEZO2

8.39e-061891126d4a25d59d88325d3b20f4287e9b1160c82961a96
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CUX2 PRMT8 LRRK2 BRINP1 CUX1 GABRA1

8.65e-0619011261bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

COL4A1 MARK1 ADAM12 GEM PIEZO2 ADAMTS9

8.91e-06191112678c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_BHLHE22|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CUX2 PRMT8 LRRK2 BRINP1 SCN9A CUX1

9.18e-06192112625460ca9ebd3d49f666394cf99ab77a5e8f77250
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRMT8 PPFIA3 SCN2A SCN3A GABRA1 GABRA5

9.46e-061931126461919ab422bc9d1fcff7a3a4757c75239041d7e
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRMT8 PPFIA3 SCN2A SCN3A GABRA1 GABRA5

9.46e-0619311260dd810ad900d3e586551622b2c1de39d76fd6a7f
ToppCelldroplet-Limb_Muscle-MUSCLE|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A1 SOX11 CEP85L MACF1 ASCC3 UTRN

9.74e-061941126e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibro-meso-mesothelial_cell-Mesothelium-Mesothelium_L.2.6.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GEM HSPA12A ADAMTS9 BRINP2 CPXM1 GABRA1

9.74e-061941126421344cc4b601d9745fa72d0af3124dab11d1d27
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SLC25A37 RYR3 EHD1 PYGL MYH15 DNAH9

1.00e-051951126d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SLC25A37 RYR3 EHD1 PYGL MYH15 DNAH9

1.00e-05195112619853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCellCOVID_non-vent-Lymphocytic-T_cell-CD8+_Memory_T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

LPCAT1 APMAP SPG11 GZMH MACF1 UTRN

1.06e-051971126836061acd7f0d5de89b16f52ec679bdf09eac9db
ToppCellControl_saline-Epithelial_alveolar-AT_2-Differentiating_AT2|Control_saline / Treatment groups by lineage, cell group, cell type

LPCAT1 LRRK2 GPAM ST3GAL5 UTRN WWC1

1.06e-05197112644a59dfb889577b3160a5b13ada1276771a00241
ToppCellTracheal-NucSeq-Stromal-Schwann-Schwann_nonmyelinating|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL4A1 GRIK2 ONECUT1 HSPA12A SCN9A AP1S2

1.06e-0519711265c88a97e8e23a5cd61885acbe1ef339ae6a1e35a
ToppCellTracheal-NucSeq-Stromal-Schwann|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL4A1 GRIK2 ONECUT1 HSPA12A SCN9A AP1S2

1.06e-051971126c1b2a3fbd5f4aeb3555d8c372efc86f1052e7c65
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated|COVID-19_Mild / Disease, condition lineage and cell class

LPCAT1 APMAP GZMH MACF1 CTSG UTRN

1.16e-0520011262281debd86e5d92e8fe0397aec9ef670800f7471
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-T/NK-gd_T|COVID-19_Severe / Disease, condition lineage and cell class

LPCAT1 APMAP ADAM12 GZMH MACF1 UTRN

1.16e-052001126f72bc3f6606ae77fe1b0a972e35b3ce0727804d9
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Gpc3_Slc18a3|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

BARD1 GRIK2 NR2E1 SCN9A AP1S2

2.51e-051371125d346086f42d8f04d3fa67fe696834284acdc7080
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADCY10 EFCAB6 ADAM12 ONECUT1 GZMH

2.79e-0514011257ca49bd7ba9381e75c10f888775df17e5d46804d
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADCY10 EFCAB6 ADAM12 ONECUT1 GZMH

2.79e-0514011251a31bc33d5723b9bc528cc0047ca5f4c80531c7a
ToppCellfacs-Heart-LV-24m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX11 SLC7A11 SLC25A37 PYGL CTSG

3.09e-0514311258f82b3c3331f20c6ded36dbfb9a48dbd9f099f93
ToppCellfacs-Heart-LV-24m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX11 SLC7A11 SLC25A37 PYGL CTSG

3.09e-05143112552832321cc848739ff6483f467d57c50c8b7395c
ToppCell356C-Myeloid-Mast_cell|356C / Donor, Lineage, Cell class and subclass (all cells)

SLC26A2 FAM53A GPR143 CTSG WNK3

3.64e-0514811251668d8a9e680da335362744f36b05446c499347e
ToppCell356C-Myeloid-Mast_cell-|356C / Donor, Lineage, Cell class and subclass (all cells)

SLC26A2 FAM53A GPR143 CTSG WNK3

3.64e-05148112518511ba10765eda937c5a710626361f7e6b9b321
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lect1_Oxtr|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

GRM1 ADAM12 RYR3 NR2E1 AP1S2

3.76e-05149112510ffd0051fb027bbebc662ca602c80d89bbf99c6
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Arhgap36_Hmcn1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

BARD1 NR2E1 SCN9A CPXM1 AP1S2

4.26e-0515311259c6fce56300ba5053efda59a438d63a808c497c0
ToppCell10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

CHST5 PRMT8 DNAH9 ANKS3 DNAH11

4.68e-05156112510d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell390C-Epithelial_cells-Epithelial-A_(AT2)|390C / Donor, Lineage, Cell class and subclass (all cells)

LRRK2 GRAMD2A C4BPA LRRC8B CRYBG3

5.27e-051601125731def6d82814ebac1a400bc7aea5f6da43ec960
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRIK2 RYR3 MYH15 USH2A DNAH9

5.27e-051601125c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell390C-Epithelial_cells-Epithelial-A_(AT2)-|390C / Donor, Lineage, Cell class and subclass (all cells)

LRRK2 GRAMD2A C4BPA LRRC8B CRYBG3

5.27e-051601125cf27b4ac4d0caa6f9b068dc8ea93472470a01a4d
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRIK2 RYR3 MYH15 USH2A DNAH9

5.27e-05160112525c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellLV-11._Adipocyte|World / Chamber and Cluster_Paper

APMAP GPAM ADAM12 PYGL LRRC8B

6.28e-0516611257e5852891714465c6228c9f955fd511ec79d0e02
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ADAM12 VN1R1 GZMH MDGA1 WWC1

6.28e-0516611259e916fc1858573358e1eb5e3789b2c9f8ef74476
ToppCell356C-Myeloid-Dendritic-cDC_activated|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

PIEZO2 ST3GAL5 RAPGEF2 RUBCN DNAH11

7.03e-051701125513d9036aa41d4d902da8baa66a66206abb6f3b0
ToppCelldroplet-Marrow-BM-1m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRK2 ANO10 FMNL2 ST3GAL5 PYGL

7.23e-0517111258a0c08f0aa3a80cd6346c81deb242e430ebd897b
ToppCell3'_v3-lymph-node_spleen-Myeloid_Dendritic-migDC|lymph-node_spleen / Manually curated celltypes from each tissue

NPR1 ADAM12 FMNL2 SLC7A11 PIEZO2

7.43e-0517211251b24bed3cd8e3fa463c5e7cefdf9e99e639e2f84
ToppCelldroplet-Marrow-nan-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRK2 FMNL2 SLC7A11 ST3GAL5 PYGL

7.43e-051721125d354424c1f861b6607dfd63b9724f4c237b30275
ToppCellCTRL-Lymphoid-pDC|Lymphoid / Disease state, Lineage and Cell class

CUX2 PFAS SLC7A11 NR2E1 SCN9A

7.84e-051741125ff4315e9fad198cc323fc987deb8652da137cf98
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

KIF27 BRINP1 AP1S1 WWC1 GABRA5

8.06e-051751125ff0789f5913c9f3c49159e40b1ec3d2ff175ec9f
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

KIF27 BRINP1 AP1S1 WWC1 GABRA5

8.06e-05175112521f8f11a8b874d4f7c47931010a2535f2a5a3373
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LPCAT1 GZMH MACF1 CTSG RUBCN

8.50e-051771125d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LPCAT1 GZMH MACF1 CTSG RUBCN

8.50e-051771125f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCellmetastatic_Lymph_Node-Endothelial_cells|metastatic_Lymph_Node / Location, Cell class and cell subclass

COL4A1 NPR1 HSPA12A PIEZO2 ADAMTS9

8.50e-05177112571bf5d4bc67bda37a0499e5ec01af7dd5254041d
ToppCellCOVID-19_Mild-Lymphoid_T/NK-NK_activated|COVID-19_Mild / Disease group, lineage and cell class

LPCAT1 GZMH MACF1 CTSG RUBCN

8.50e-0517711256978a22fef40c8b455342373abe7593f5ede0fa4
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

LPCAT1 GZMH MACF1 CTSG RUBCN

8.50e-051771125936ab2b180a052387124f68d0c7f41c0b164e748
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LPCAT1 GZMH MACF1 CTSG RUBCN

8.50e-051771125d5aeda113afaa2425874394610344570c9078478
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_2|356C / Donor, Lineage, Cell class and subclass (all cells)

PKD1L1 ADAM12 GEM NUP155 ANKS3

8.73e-0517811258b939659f713eea50a1a6e28b571f680ca0b4c12
ToppCellE17.5-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell_of_alveolus|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ACE GEM CASZ1 RGL1 USH2A

8.73e-051781125982205ba117a4c7b7e9b713689a5b69190f0bca9
ToppCell390C-Epithelial_cells-Epithelial-B_(AT2)|390C / Donor, Lineage, Cell class and subclass (all cells)

LPCAT1 LRRK2 SCN9A C4BPA WWC1

8.96e-051791125466da2bc3bfc534ffe111c8c28ece7a3cfa08051
ToppCell390C-Epithelial_cells-Epithelial-B_(AT2)-|390C / Donor, Lineage, Cell class and subclass (all cells)

LPCAT1 LRRK2 SCN9A C4BPA WWC1

8.96e-051791125f4bdebb77d39e63160fbf3a85a340ce4d52b7cfd
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-pDC|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CUX2 SLC7A11 SCN9A AP1S2 RUBCN

8.96e-051791125bbd4f8e988ef3f343aaedbc992b70f2bb6aff5f6
ToppCellCOPD-Myeloid-pDC|Myeloid / Disease state, Lineage and Cell class

CUX2 PFAS SCN9A RAPGEF2 RUBCN

8.96e-05179112529b058c5e33fda9f0d738c074bdb67ff16b9b6d5
ToppCellwk_20-22-Hematologic-Meg-ery-Definitive_erythroblast|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ADCY10 MARK3 RIOK3 SLC25A37 RAPGEF2

9.69e-0518211250c77ef4556c1d1512ebe9077df858b28f9e38dd5
ToppCellCOPD-Myeloid-Mast|World / Disease state, Lineage and Cell class

SLC26A2 ADAM12 RYR3 RAPGEF2 WNK3

9.69e-05182112568a1e7b804f309bfd6c23d65fad20a9a962712ae
ToppCellFetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL4A1 NR2E3 MARK1 FMNL2 ADAMTS9

9.69e-051821125ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCellcellseq2-Immune-Hematopoietic-Granulocytic|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LRRK2 SLC25A37 TLR1 PYGL CTSG

9.94e-051831125cfbf8539104cef9ca830ad4f6bb278746f7078f7
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL4A1 PIEZO2 SCN3A SCN9A UTRN

9.94e-0518311254d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

TMEM30B PRMT8 SCN9A WWC1 GABRA1

9.94e-051831125c5b10571599dc26476170b54b53f09c23e6b3117
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PKD1L1 ACE ADAM12 GEM ANKS3

9.94e-051831125f142b320023eef00b48d4820c46214c9794d37e7
ToppCellcellseq2-Immune-Hematopoietic|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LRRK2 SLC25A37 TLR1 PYGL CTSG

9.94e-051831125324ec4374b552da7ce03809945b3a0798342d4ba
ToppCellFrontal_cortex-Neuronal-Excitatory|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

AP1S1 ST3GAL5 SCN2A MARK2 GABRA5

1.02e-0418411256e17c8151d6dc543de16d804db956c63c3fda414
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NPR1 LRRK2 DNAH7 WWC1 DNAH11

1.02e-041841125da06ff24ee2b2cf4715fdfce43030b2da9e0aaf8
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LPCAT1 LRRK2 ST3GAL5 C4BPA WWC1

1.02e-041841125ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCellCOVID-19_Severe-gd_T|COVID-19_Severe / Disease condition and Cell class

LPCAT1 ADAM12 GZMH MACF1 RUBCN

1.02e-041841125791f1bcb954aadc63d4117c400537d036f68734d
ToppCelltumor_Lung-Fibroblasts-Mesothelial_cells|tumor_Lung / Location, Cell class and cell subclass

GRIK2 PIEZO2 ADAMTS9 BRINP2 CPXM1

1.02e-041841125b0a251030d127858e68cf164be158f209a4d720f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MARK1 GEM PIEZO2 SCN3A UTRN

1.05e-04185112551dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LPCAT1 LRRK2 ST3GAL5 C4BPA WWC1

1.05e-0418511250d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCellCOVID_non-vent-Myeloid-Monocytic-Neutrophil|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

LRRK2 SLC25A37 HHATL TLR1 PYGL

1.05e-0418511252c89af7cdf5306b900a5b8ec4fdfb8210e5667ed
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KIF27 SLC26A2 PYGB DNAH9 WWC1

1.05e-04185112505bc89a566b0db90ae06506e067190a4739a0974
ToppCellfacs-Brain_Non-Myeloid-Cerebellum|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRM1 ADAM12 SCN2A MDGA1 GABRA1

1.05e-041851125c083a4974590b9ed3ecafedd3e9cdebc5047fe39
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MARK1 GEM PIEZO2 SCN3A UTRN

1.05e-041851125a8c02cec3c414f3a0da9f2d6d28ce563b0030705
DrugBetahistine mesylate [54856-23-4]; Up 200; 17.2uM; MCF7; HT_HG-U133A

COL4A1 NR2E3 PRMT8 EFCAB6 GRM1 VN1R1 SLC7A11 RGL1 UTRN

6.02e-0719811294956_UP
DrugIvermectin [70288-86-7]; Up 200; 4.6uM; MCF7; HT_HG-U133A

NR2E3 SLC26A2 GRM1 ACE ONECUT1 SLC7A11 SLC25A37 NUP188

4.43e-0618911287206_UP
Drugpropofol

ACE RYR3 SCN3A SCN9A PYGB PYGL GABRA1 GABRA5

4.78e-061911128CID000004943
Drugmeprobamate

ACE PYGB PYGL MDGA1 GABRA1 GABRA5

4.83e-06881126CID000004064
DrugDisulfiram [97-77-8]; Down 200; 13.4uM; HL60; HG-U133A

CHST5 LPCAT1 ACTR8 PFAS SLC7A11 AP1S1 UTRN CUX1

5.37e-0619411281369_DN
DrugSecobarbital

GRIK2 GABRA1 GABRA5

1.36e-05101123DB00418
DrugMetharbital

GRIK2 GABRA1 GABRA5

1.36e-05101123DB00463
DrugPentobarbital

GRIK2 GABRA1 GABRA5

1.36e-05101123DB00312
DrugTalbutal

GRIK2 GABRA1 GABRA5

1.36e-05101123DB00306
DrugButalbital

GRIK2 GABRA1 GABRA5

1.36e-05101123DB00241
DrugButabarbital

GRIK2 GABRA1 GABRA5

1.36e-05101123DB00237
DrugBarbituric acid derivative

GRIK2 GABRA1 GABRA5

1.36e-05101123DB01496
DrugBarbital

GRIK2 GABRA1 GABRA5

1.36e-05101123DB01483
DrugHexobarbital

GRIK2 GABRA1 GABRA5

1.36e-05101123DB01355
DrugAprobarbital

GRIK2 GABRA1 GABRA5

1.36e-05101123DB01352
DrugAmobarbital

GRIK2 GABRA1 GABRA5

1.36e-05101123DB01351
DrugHeptabarbital

GRIK2 GABRA1 GABRA5

1.36e-05101123DB01354
DrugButethal

GRIK2 GABRA1 GABRA5

1.36e-05101123DB01353
DrugMethylphenobarbital

GRIK2 GABRA1 GABRA5

1.36e-05101123DB00849
DrugPrimidone

GRIK2 GABRA1 GABRA5

1.36e-05101123DB00794
Drugoctopamine

ADCY10 GPR143 SCN2A NR2E1 PYGB PYGL

1.66e-051091126CID000004581
Drugphenformin

MARK1 MARK3 STRADA MARK2

1.79e-05321124CID000008249
DrugThiopental

GRIK2 GABRA1 GABRA5

1.86e-05111123DB00599
DrugPhenobarbital

GRIK2 GABRA1 GABRA5

1.86e-05111123DB01174
Drug5-(2-chloroethyl)uracil

PYGB PYGL

2.40e-0521122CID010442204
Drug6878P

PYGB PYGL

2.40e-0521122CID002725013
DrugAC1LBRFU

PYGB PYGL

2.40e-0521122CID000562981
DrugAC1L19D1

TRPM5 PYGB PYGL

2.47e-05121123CID000000494
Drugriluzole

GRIK2 GRM1 RYR3 SCN3A SCN9A GABRA1 GABRA5

2.49e-051741127CID000005070
Drug1,2-dichlorohexafluorocyclobutane

GRIK2 GRM1 RYR3 SCN2A

3.23e-05371124CID000009643
Drugcelecoxib; Up 200; 10uM; MCF7; HT_HG-U133A_EA

SLC26A2 GRM1 ACE SLC7A11 GEM ST3GAL5 GZMH

4.22e-051891127922_UP
Druganiracetam

GPR143 GRIK2 GRM1 MARK2 HERC2 GABRA5

4.50e-051301126CID000002196
DrugEquilin [474-86-2]; Up 200; 15uM; MCF7; HT_HG-U133A

RIOK3 GRM1 ADAM12 SLC7A11 AP1S1 C4BPA NUP188

4.52e-0519111273377_UP
Drugketamine

GRIK2 GRM1 ACE F10 SCN3A SCN9A GABRA1 GABRA5

4.68e-052621128CID000003821
DrugGvapspat amide

RYR3 PYGB PYGL

5.05e-05151123CID000125015
DrugClozapine [5786-21-0]; Up 200; 12.2uM; HL60; HT_HG-U133A

PIEZO1 VN1R1 SLC7A11 RGL1 MKLN1 LRRC8B UTRN

5.32e-0519611271289_UP
DrugAG-013608 [351320-38-2]; Up 200; 10uM; MCF7; HT_HG-U133A

SOX11 ADAM12 SLC7A11 RYR3 ADAMTS9 SCN3A NUP188

5.32e-0519611276435_UP
DrugMonocrotaline [315-22-0]; Up 200; 12.2uM; MCF7; HT_HG-U133A

NR2E3 RIOK3 PPFIA3 SLC7A11 AP1S1 ST3GAL5 UTRN

5.49e-0519711272749_UP
DrugButylparaben [94-26-8]; Up 200; 20.6uM; MCF7; HT_HG-U133A

NR2E3 GRM1 VN1R1 SLC7A11 BRINP2 MARK2 DNAH9

5.49e-0519711275245_UP
DrugEpiandrosterone [481-29-8]; Up 200; 13.8uM; MCF7; HT_HG-U133A

SOX11 CHST5 NPR1 PEX6 VN1R1 SLC7A11 MARK2

5.85e-0519911275687_UP
DrugSodium

NPR1 GRM1 SCN2A SCN3A SCN9A

5.97e-05841125ctd:D012964
DrugSodium thioglucse

NPR1 PYGB PYGL

6.19e-05161123CID000151466
Drug5-methylthioribose-1-phosphate

TRPM5 PYGB PYGL

6.19e-05161123CID000000465
Drug3,5-dimethylphenyl isocyanate

PYGB PYGL

7.17e-0531122CID000521488
Drug5'-deoxy-5'-fluoro-5'-(methylthio)adenosine

PYGB PYGL

7.17e-0531122CID000147839
DrugN-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide

SCN3A SCN9A

7.17e-0531122ctd:C561228
DrugNSC758405

PYGB PYGL

7.17e-0531122CID000003201
Drug3,5-dinitrophenyl phosphate

PYGB PYGL

7.17e-0531122CID000151920
Drugpyridoxal phosphoglucose

PYGB PYGL

7.17e-0531122CID000196007
DrugAspaminol

PYGB PYGL

7.17e-0531122CID003084278
Drug5-ethyl-4-hydroxy-2-methyl-3(2H)-furanone

PYGB PYGL

7.17e-0531122CID000093111
Drugadenosine-5'-chloromethylphosphonate

PYGB PYGL

7.17e-0531122CID000191554
Drughydan

PYGB PYGL

7.17e-0531122CID000008360
DrugEHMF

PYGB PYGL

7.17e-0531122CID000033931
DrugAC1L29EX

PYGB PYGL

7.17e-0531122CID000043221
Drugpyridoxal 5'-methylenephosphonate

PYGB PYGL

7.17e-0531122CID003082249
DrugPlp 5'-mpa

PYGB PYGL

7.17e-0531122CID003082151
Drugglucose-1,2-cyclic phosphate

PYGB PYGL

7.17e-0531122CID000191723
Drug3'-FFdUrd

PYGB PYGL

7.17e-0531122CID000072260
Drug2',3',4',5,5'-pentachloro-2-biphenylol

PYGB PYGL

7.17e-0531122CID000119518
DrugAC1L8XK3

PYGB PYGL

7.17e-0531122CID000409735
DrugN-acetyl-N'-beta-D-glucopyranosyl urea

PYGB PYGL

7.17e-0531122CID000446801
Drugriboflavin tetraacetate

PYGB PYGL

7.17e-0531122CID000094186
Drug2,5-dimethyl-3-furanone

PYGB PYGL

7.17e-0531122CID000085730
Drug3,5-dinitrophenol

PYGB PYGL

7.17e-0531122CID000011459
DrugZonisamide

SCN2A SCN3A SCN9A

7.49e-05171123DB00909
DrugScorpion Venoms

SCN2A SCN3A SCN9A

8.96e-05181123ctd:D012604
Drugpentobarbital

GRIK2 ACE SCN3A SCN9A CUX1 GABRA1 GABRA5

1.23e-042241127CID000004737
Drugsulfacetamide

BRINP1 MAGEE1 EHD1 MARK2

1.35e-04531124CID000005320
Druggalocitabine

PYGB PYGL

1.43e-0441122CID000065950
Drugrhenium sulfide

CUX2 CUX1

1.43e-0441122CID000159414
Drug5-deoxyribose-1-phosphate

PYGB PYGL

1.43e-0441122CID000135786
DrugFlumazenil

GABRA1 GABRA5

1.43e-0441122DB01205
Drugingliforib

PYGB PYGL

1.43e-0441122CID006451325
Druguric acid riboside

PYGB PYGL

1.43e-0441122CID000164933
Drugpseudo-dl-glucose

PYGB PYGL

1.43e-0441122CID000125259
Drugperfluorohexanoic acid

LPCAT1 PFAS

1.43e-0441122CID000067542
Drugpyridoxal diphosphate

PYGB PYGL

1.43e-0441122CID000125696
Drug2,5-anhydro-D-mannitol 1-phosphate

PYGB PYGL

1.43e-0441122CID000189134
DrugAC1LAMW2

PYGB PYGL

1.43e-0441122CID000491364
DrugFdUrd-C8

PYGB PYGL

1.43e-0441122CID000094262
DrugMem-CC

PYGB PYGL

1.43e-0441122CID003081269
Drug2H-5a

PYGB PYGL

1.43e-0441122CID000440102
DrugBCIp4A

PYGB PYGL

1.43e-0441122CID000192417
Drug3'-chloromethotrexate

PYGB PYGL

1.43e-0441122CID000097703
DrugAC1L9JWW

ACE SCN2A DNAH11

1.44e-04211123CID000446637
Druggabapentin

GRM1 RYR3 SCN3A SCN9A GABRA1 GABRA5

1.91e-041691126CID000003446
Drugthiopental

RYR3 PYGB PYGL GABRA1 GABRA5

2.32e-041121125CID003000715
Drugheptulose-2-P

PYGB PYGL

2.38e-0451122CID000124823
Drug6-FPLP

PYGB PYGL

2.38e-0451122CID000146246
Druggluconohydroximo-1,5-lactone

PYGB PYGL

2.38e-0451122CID009576855
DrugEszopiclone

GABRA1 GABRA5

2.38e-0451122DB00402
DrugDHPBU

PYGB PYGL

2.38e-0451122CID000125914
Drug5'-isobutylthioinosine

PYGB PYGL

2.38e-0451122CID003080910
DrugAC1L1DX8

NPR1 ACE

2.38e-0451122CID000002546
DrugZopiclone

GABRA1 GABRA5

2.38e-0451122DB01198
Drugindirubin-5-sulphonate

PYGB PYGL

2.38e-0451122CID005288641
DrugVaraU

PYGB PYGL

2.38e-0451122CID000126501
DrugAC1LCUXJ

PYGB PYGL

2.38e-0451122CID000656425
Drug6-amino-5-bromouracil

PYGB PYGL

2.38e-0451122CID000080578
DiseaseInfantile Severe Myoclonic Epilepsy

SCN2A SCN9A RAPGEF2 GABRA1

1.18e-07131084C0751122
Diseasevisual impairment and progressive phthisis bulbi (implicated_via_orthology)

MARK1 MARK3 MARK2

1.90e-0741083DOID:0070356 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN2A SCN3A SCN9A

5.62e-06101083DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN2A SCN3A SCN9A

5.62e-06101083DOID:0080422 (implicated_via_orthology)
DiseaseSitus Inversus

PKD1L1 DNAH9 ANKS3

7.70e-06111083C0037221
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN2A SCN3A SCN9A

1.02e-05121083DOID:0060170 (implicated_via_orthology)
DiseaseHemorrhage, intracerebral, susceptibility to

COL4A1 ACE

3.97e-0531082cv:C3281105
DiseaseHEMORRHAGE, INTRACEREBRAL, SUSCEPTIBILITY TO

COL4A1 ACE

3.97e-0531082614519
Diseaseanxiety disorder (implicated_via_orthology)

SCN2A SCN3A SCN9A

6.98e-05221083DOID:2030 (implicated_via_orthology)
DiseaseSchizophrenia

ADNP2 GRIK2 GRM1 ACE ADAM12 HSPA12A NR2E1 MARK2 MDGA1 WNK3 GABRA1 GABRA5

9.61e-0588310812C0036341
DiseaseDisorder of eye

COL4A1 CYP4V2 TMEM126A NR2E3 GPR143 USH2A

1.33e-042121086C0015397
Diseaseneurodegenerative disease (implicated_via_orthology)

MARK1 MARK3 LRRK2 GRIK2 MARK2

1.99e-041451085DOID:1289 (implicated_via_orthology)
DiseaseSpinocerebellar Ataxia Type 2

ANO10 GRM1 RUBCN

2.63e-04341083C0752121
DiseaseSpinocerebellar Ataxia Type 1

ANO10 GRM1 RUBCN

2.63e-04341083C0752120
DiseaseSpinocerebellar Ataxia Type 5

ANO10 GRM1 RUBCN

2.63e-04341083C0752123
DiseaseSpinocerebellar Ataxia Type 7

ANO10 GRM1 RUBCN

2.63e-04341083C0752125
DiseaseSpinocerebellar Ataxia Type 6 (disorder)

ANO10 GRM1 RUBCN

2.63e-04341083C0752124
DiseaseAtaxia, Spinocerebellar

ANO10 GRM1 RUBCN

2.63e-04341083C0087012
Diseaseunipolar depression, bipolar disorder

GRIK2 BRINP1 MYH15 MARK2 ASCC3

2.79e-041561085EFO_0003761, MONDO_0004985
DiseaseSpinocerebellar Ataxia Type 4

ANO10 GRM1 RUBCN

2.87e-04351083C0752122
Diseasenon-high density lipoprotein cholesterol measurement

ADNP2 PEX6 GPAM GRIK2 VN1R1 ONECUT1 PYGB MARK2 ASCC3 DNAH11

2.94e-0471310810EFO_0005689
DiseaseEarly Childhood Epilepsy, Myoclonic

SCN9A RAPGEF2

3.66e-0481082C0393695
DiseaseIdiopathic Myoclonic Epilepsy

SCN9A RAPGEF2

3.66e-0481082C0338478
DiseaseSymptomatic Myoclonic Epilepsy

SCN9A RAPGEF2

3.66e-0481082C0338479
DiseaseBenign Infantile Myoclonic Epilepsy

SCN9A RAPGEF2

3.66e-0481082C0751120
DiseaseMyoclonic Encephalopathy

SCN9A RAPGEF2

3.66e-0481082C0438414
DiseaseMyoclonic Absence Epilepsy

SCN9A RAPGEF2

3.66e-0481082C0393703
DiseaseBipolar Disorder

CUX2 GRIK2 ACE SCN2A NR2E1 MDGA1 GABRA1 GABRA5

3.78e-044771088C0005586
DiseaseMyoclonic Epilepsy

SCN9A RAPGEF2

4.70e-0491082C0014550
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

SCN2A SCN9A

4.70e-0491082C3502809
DiseaseSitus ambiguous

PKD1L1 DNAH9

4.70e-0491082C1167664
Diseasesodium measurement

CUX2 BRINP1 SCN2A PYGL

5.68e-041031084EFO_0009282
DiseaseEpilepsy, Myoclonic, Infantile

SCN9A RAPGEF2

5.86e-04101082C0917800
DiseaseMalignant neoplasm of salivary gland

SOX11 PYGB MARK2

6.05e-04451083C0220636
DiseaseSalivary Gland Neoplasms

SOX11 PYGB MARK2

6.88e-04471083C0036095
DiseaseMyoclonic Astatic Epilepsy

SCN9A RAPGEF2

7.14e-04111082C0393702
Diseaselifestyle measurement, alcohol consumption measurement

GRIK2 BRINP1 PIEZO2 UTRN

8.59e-041151084EFO_0007878, EFO_0010724
Diseasehematologic cancer (implicated_via_orthology)

CUX2 CUX1

1.01e-03131082DOID:2531 (implicated_via_orthology)
Diseasebilirubin measurement

CUX2 PIEZO1 PEX6 GPAM SLC25A37 LRRC8B DNAH11

1.23e-034421087EFO_0004570
DiseaseSitus ambiguus

PKD1L1 DNAH9

1.35e-03151082C0266642
Diseasecathepsin L1 measurement

LRRK2 GRM1

1.54e-03161082EFO_0010619
DiseaseCerebrovascular accident

COL4A1 ACE CASZ1

1.54e-03621083C0038454
Diseaselifestyle measurement, anxiety disorder measurement

GRIK2 BRINP1 PIEZO2 USH2A

1.64e-031371084EFO_0007795, EFO_0010724
Diseasecolorectal cancer

GPR143 GRIK2 HHATL HSPA12A ADAMTS9 MACF1 PYGL HERC2

1.73e-036041088MONDO_0005575
Diseasephosphatidylcholine 40:6 measurement

RAPGEF2 DNAH9

1.74e-03171082EFO_0010389
Diseaselateral occipital cortex volume measurement

BRINP1 UTRN

1.74e-03171082EFO_0010311
DiseaseMHPG measurement, 5-HIAA measurement

ADAM12 PIEZO2

1.74e-03171082EFO_0005132, EFO_0005133
Diseaseaspartate aminotransferase measurement

CUX2 KIF27 MARK3 SLC26A2 PIEZO1 GPAM RGL1 HSPA12A ADAMTS9 GCN1

1.80e-0390410810EFO_0004736
Diseasephospholipids:total lipids ratio, intermediate density lipoprotein measurement

GPAM SPG11 MACF1

1.93e-03671083EFO_0008595, EFO_0020946
Diseasesquamous cell carcinoma

MARK3 HERC2 DNAH11

1.93e-03671083EFO_0000707
Diseaseacetate measurement

APMAP SPG11

2.42e-03201082EFO_0010112
Diseasealpha-tocopherol measurement

SCN3A USH2A

2.42e-03201082EFO_0007898
DiseaseCOVID-19 (is_implicated_in)

ACE C4BPA

2.66e-03211082DOID:0080600 (is_implicated_in)
Diseasecerebellar cortex volume measurement

CUX1 WWC1

2.66e-03211082EFO_0010291
DiseaseAutistic Disorder

MARK1 GRIK2 ACE GABRA1 GABRA5

2.77e-032611085C0004352
DiseaseOvarian Serous Adenocarcinoma

MARK1 LRRK2

3.19e-03231082C1335177
Diseasephosphatidylserines measurement

GRIK2 ASCC3

3.19e-03231082EFO_0020049
DiseaseCoronary heart disease

ACE DNAH11

3.48e-03241082C0010068
Diseaseamino acid measurement

SOX11 GRIK2 GRM1 ADAM12 DNAH7 RYR3 RGL1 BRINP2

3.51e-036781088EFO_0005134

Protein segments in the cluster

PeptideGeneStartEntry
LHRKRKMAAWPFSRL

C4BPA

11

P04003
NSIKMWFSPRSKKVR

BARD1

141

Q99728
FSRWKTIGSLRPMKQ

CRYBG3

2821

Q68DQ2
FDPRWRKRMSLTLKS

BRINP1

516

O60477
LKQGWTPRRMFKEAD

ACE

911

P12821
KRFWIIEDMSPFGKR

CASZ1

1401

Q86V15
AIWSKKMSNGTRRIP

ACTR8

116

Q9H981
WHKLSLKGREPFVRM

CUX1

1171

P39880
KVSHFLPWIKRTMKR

GZMH

231

P20718
ARKPKMCSFLEWRDL

AP1S1

41

P61966
AVIKWMKRIPFVLSA

CPXM1

481

Q96SM3
RVPKDRSWKAAKVFM

DNAH11

3231

Q96DT5
FLDWRKMKLLPRKSH

ADAM12

286

O43184
MLNTVIFARDKWLKP

PRMT8

196

Q9NR22
SERPWIKRMIFKLFS

APMAP

336

Q9HDC9
STSWRFMEKLIRTLP

ADCY10

651

Q96PN6
YAKKLWTAPELLRMA

NPR1

696

P16066
REKMLSRFGRFWKKP

CER1

76

O95813
WSKLTQKGREPFIRM

CUX2

941

O14529
APFLKWMREKTVRCL

ADNP2

736

Q6IQ32
FWLATIERSEMFKKP

COL4A1

1631

P02462
YVGSRPIKLRKSMWK

RBM42

446

Q9BTD8
RLLFMAVKWAKNLPV

NR2E3

226

Q9Y5X4
YRLKKTWAAVPRDRM

RGL1

341

Q9NZL6
PLSWNVAVKFLMARK

PTPN9

41

P43378
SMPRKARRFWGKIVA

GEM

261

P55040
RWGTLLMKRKFEEPR

ANO10

271

Q9NW15
RKPKMCSFLEWRDLK

AP1S2

41

P56377
WFKNGKPARMSKRLL

MDGA1

371

Q8NFP4
SKMARTLPTKEFLWA

OTOA

791

Q7RTW8
WRKVVDFLLKAIMRT

LPCAT1

91

Q8NF37
TWLDFAMAVKRDSRK

KIAA0100

2156

Q14667
FAKLCTMVAPKLRSW

HHATL

86

Q9HCP6
FLWGPRARAETSKMK

MAGEB17

271

A8MXT2
WGPRARLETSKMKAL

MAGEE1

901

Q9HCI5
LKEMRFISPRKWTQG

WWC1

351

Q8IX03
MSKFKLLSSLPRWRR

HERC2

1531

O95714
AKSFSRSPSWRKMFR

PPFIA3

1121

O75145
MTKAADPRFRPRWKV

CANT1

31

Q8WVQ1
LKWASRPESMKLSGR

KIF27

1261

Q86VH2
SPEKLPRWREMFFKV

PEX6

371

Q13608
PRWREMFFKVKKTVG

PEX6

376

Q13608
PWSKLKSGRETFRRM

ONECUT1

336

Q9UBC0
MKPWLFNIKARASSS

LRRK2

1431

Q5S007
SWKDERLKFKGPMTV

GABRA1

96

P14867
RQSWKDERLRFKGPM

GABRA5

101

P31644
RFTMEVPKKLTEWFK

GCN1

416

Q92616
FKIKRPAAWVDLMIA

HSPA12A

371

O43301
MLSSFPHRKTWRKSK

GARIN1B

1

Q96KD3
ILRLKFTEMGKIPRW

LRRC8B

491

Q6P9F7
STSWFRKPMTRAELV

MACF1

561

Q9UPN3
LFKSRDPFWNRMKKP

NUP155

1306

O75694
VRWVPKYSGILMKDR

ADAMTS9

671

Q9P2N4
SIKPSTMWFGERSRK

DCLRE1C

286

Q96SD1
KIVHCWRPMRRTFKS

EFCAB6

1431

Q5THR3
LKPVRTAAKTTWFIM

GPR143

281

P51810
RAEMEILPKPWRKSF

DNAH7

246

Q8WXX0
VVWMRTAALPTFRKL

TMEM30B

251

Q3MIR4
DMKDFRPLRKWSSLS

CEP85L

146

Q5SZL2
NKWRSRRKMLTPTFH

CYP4V2

141

Q6ZWL3
KTKFRMPVFNWVALK

FMNL2

621

Q96PY5
KPRSLRFTWSMKTTS

MARK1

696

Q9P0L2
REAKPRSLRFTWSMK

MARK2

686

Q7KZI7
KEAKPRSLRFTWSMK

MARK3

651

P27448
LFGPKRKMTSAIARW

ANKS3

471

Q6ZW76
PWIRTTMRSFKLLDQ

CTSG

236

P08311
KTYQIMKRRPVWTDL

DNAH9

2166

Q9NYC9
RVPKDRSWKAAKVTM

DNAH9

3201

Q9NYC9
WIDRSMKTRGLPKAK

F10

461

P00742
KPWRFGTRFMSLIKE

GRIK2

351

Q13002
KKICTRKPRFMSAWA

GRM1

691

Q13255
EMKWRKVCPSSRSLS

GRAMD2A

206

Q8IUY3
IKRVIMERDTYPRKW

DKC1

366

O60832
MFSWVSKDARRKKEP

EHD1

1

Q9H4M9
MAIPSRVLRKWDFSK

RUBCN

756

Q92622
MWEKVLTFLRLETPK

PKD1L1

2761

Q8TDX9
RLLFMSIKWAKSVPA

NR2E1

191

Q9Y466
RWKMLKDSEKIPFIR

SOX11

86

P35716
MRFIDKTSALSPWTK

USH2A

2681

O75445
LFSWDKVVKMSPIER

UTRN

196

P46939
MSFLVSKPERIRRWV

STRADA

1

Q7RTN6
SYWIRTSKPVFRKML

TMEM126A

146

Q9H061
PKMRLDDFWSLKLCR

MKLN1

611

Q9UL63
WMRLFFKIKPLVKSS

MYH15

841

Q9Y2K3
WKESLMSRKRPFVGR

GPAM

51

Q9HCL2
LKKIMRTEGFWRPLR

SLC25A37

91

Q9NYZ2
RVFKLAKSWPTLNML

SCN9A

841

Q15858
AMVKKETLPFWVRLF

ST3GAL5

276

Q9UNP4
RRSWLMAKCAVPKSD

SPATA31E1

786

Q6ZUB1
LRVFKLAKSWPTLNM

SCN3A

856

Q9NY46
LKSLMARRTYLEWPK

TLR1

746

Q15399
WFDPSWRKRMLLTLK

BRINP2

541

Q9C0B6
RALFEIALRKRWPTM

ASCC3

1091

Q8N3C0
RMWLPRFSSKTVTVL

CHST5

21

Q9GZS9
FSKLNPRKIIRMWAE

RIOK3

316

O14730
RTFMIKFPWKLTDAI

SPG11

651

Q96JI7
DPALMFRTRKKKWRS

RAPGEF2

916

Q9Y4G8
DKKPRWFRIMSEKIT

SLC7A11

471

Q9UPY5
DKSKSSFLIMWRRPE

VPS25

91

Q9BRG1
KTFNWPISLRKHMRT

ZNF555

431

Q8NEP9
QPFAMKSWLRDVLRK

TRPM5

76

Q9NZQ8
LRGALRKFRDLPKMW

SLC26A2

491

P50443
RDVAMWFSKRLPTFV

RYR3

1231

Q15413
WVLGKMPRKEFFLQR

PFAS

631

O15067
RVFKLAKSWPTLNML

SCN2A

856

Q99250
RWMEIKIRSPRFIDF

VN1R1

156

Q9GZP7
LYRSPETMIKWTREK

PIEZO2

2736

Q9H5I5
TMRLWSAKAPNDFKL

PYGB

241

P11216
RDSAMLVLRTKPKFW

NUP188

996

Q5SRE5
RCLKRLKMSWFLPTV

TMEM168

671

Q9H0V1
LYRSPETMIKWTREK

PIEZO1

2506

Q92508
FLKMTTWILPKITRR

ERVK-19

446

Q9WJR5
MRIFVDIEKLPWSKA

PYGL

351

P06737
MRKTWRRFEVPTSKS

RNF39

191

Q9H2S5
RFKVMKPKVLRSWCR

WNK3

241

Q9BYP7
RWTRPSLDFLKMTQT

FAM53A

281

Q6NSI3