Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbenzodiazepine receptor binding

RIMBP3 RIMBP3C RIMBP3B

1.56e-075513GO:0030156
GeneOntologyMolecularFunctioncalcium/calmodulin-dependent protein kinase activity

CAMK2A CAMK2D CAMK2G

4.40e-0527513GO:0004683
GeneOntologyBiologicalProcesspositive regulation of collateral sprouting in absence of injury

WNT3 WNT3A

5.53e-062492GO:0048697
GeneOntologyBiologicalProcessregulation of collateral sprouting in absence of injury

WNT3 WNT3A

1.66e-053492GO:0048696
GeneOntologyBiologicalProcessregulation of protein localization to cell periphery

MISP CAMK2A CAMK2D CAMK2G WNT3A

5.24e-05171495GO:1904375
GeneOntologyBiologicalProcesscollateral sprouting in absence of injury

WNT3 WNT3A

5.50e-055492GO:0048669
GeneOntologyBiologicalProcessneuromuscular synaptic transmission

RIMBP3 RIMBP3C RIMBP3B

8.51e-0536493GO:0007274
GeneOntologyBiologicalProcessregulation of relaxation of cardiac muscle

CAMK2D CAMK2G

1.97e-049492GO:1901897
GeneOntologyBiologicalProcessregulation of protein localization to plasma membrane

CAMK2A CAMK2D CAMK2G WNT3A

2.42e-04128494GO:1903076
GeneOntologyBiologicalProcessestablishment of centrosome localization

MISP PAFAH1B1

2.46e-0410492GO:0051660
GeneOntologyBiologicalProcessaxon extension

WNT3 WNT3A PAFAH1B1 EDN2

2.96e-04135494GO:0048675
GeneOntologyBiologicalProcessnegative regulation of axon extension involved in axon guidance

WNT3 WNT3A

3.00e-0411492GO:0048843
GeneOntologyBiologicalProcessspermatid development

RIMBP3 TTC21A PAFAH1B1 RIMBP3C RIMBP3B

3.85e-04262495GO:0007286
GeneOntologyBiologicalProcessprotein localization to cell junction

VWC2 LSR CAMK2A MAPK8IP3

4.20e-04148494GO:1902414
GeneOntologyBiologicalProcesspositive regulation of collateral sprouting

WNT3 WNT3A

4.24e-0413492GO:0048672
GeneOntologyBiologicalProcessregulation of neuron migration

FBXO31 CAMK2A MAPK8IP3

4.32e-0462493GO:2001222
GeneOntologyBiologicalProcessspermatid differentiation

RIMBP3 TTC21A PAFAH1B1 RIMBP3C RIMBP3B

4.56e-04272495GO:0048515
GeneOntologyBiologicalProcessprotein localization to cell periphery

VWC2 MISP CAMK2A CAMK2D CAMK2G WNT3A

4.70e-04422496GO:1990778
GeneOntologyCellularComponentcalcium- and calmodulin-dependent protein kinase complex

CAMK2A CAMK2D CAMK2G

1.36e-075513GO:0005954
GeneOntologyCellularComponentendocytic vesicle membrane

CAMK2A CAMK2D WNT3 CAMK2G WNT3A SYT9

1.25e-05212516GO:0030666
GeneOntologyCellularComponentmanchette

RIMBP3 RIMBP3C RIMBP3B

4.29e-0528513GO:0002177
GeneOntologyCellularComponentplasma membrane bounded cell projection cytoplasm

CAMK2A PAFAH1B1 RSPH10B CFAP46 MAPK8IP3 KLHL17

1.18e-04317516GO:0032838
GeneOntologyCellularComponentneuron projection cytoplasm

CAMK2A PAFAH1B1 MAPK8IP3 KLHL17

1.50e-04110514GO:0120111
GeneOntologyCellularComponentcytoplasmic region

CAMK2A PAFAH1B1 RSPH10B CFAP46 MAPK8IP3 KLHL17

2.34e-04360516GO:0099568
GeneOntologyCellularComponentastral microtubule

MISP PAFAH1B1

3.16e-0411512GO:0000235
GeneOntologyCellularComponentendocytic vesicle

CAMK2A CAMK2D WNT3 CAMK2G WNT3A SYT9

3.31e-04384516GO:0030139
GeneOntologyCellularComponentaster

MISP PAFAH1B1

3.79e-0412512GO:0005818
GeneOntologyCellularComponentWnt signalosome

WNT3 WNT3A

6.85e-0416512GO:1990909
MousePhenodetached sperm flagellum

RIMBP3 TTC21A RIMBP3C RIMBP3B

2.69e-0721384MP:0008893
MousePhenokinked sperm flagellum

RIMBP3 TTC21A RIMBP3C RIMBP3B

1.54e-0556384MP:0009237
MousePhenoectopic manchette

RIMBP3 RIMBP3C RIMBP3B

1.74e-0519383MP:0009377
MousePhenoabsent limbs

WNT3 WNT3A

1.99e-048382MP:0000549
MousePhenoabnormal ether lipid level

ACBD5 PEX10

1.99e-048382MP:0012220
MousePhenodetached acrosome

RIMBP3 RIMBP3C RIMBP3B

2.27e-0444383MP:0009231
MousePhenoabnormal manchette morphology

RIMBP3 RIMBP3C RIMBP3B

2.43e-0445383MP:0009376
DomainCaMKII_AD

CAMK2A CAMK2D CAMK2G

6.78e-084493PF08332
DomainCa/CaM-dep_prot_kinase-assoc

CAMK2A CAMK2D CAMK2G

6.78e-084493IPR013543
Domain-

CAMK2A CAMK2D CAMK2G

4.76e-06134933.10.450.50
DomainWnt3

WNT3 WNT3A

6.74e-062492IPR009141
DomainNTF2-like_dom

CAMK2A CAMK2D CAMK2G

7.55e-0615493IPR032710
DomainCa/CaM-dep_Ca-dep_prot_Kinase

CAMK2A CAMK2D CAMK2G

7.87e-0469493IPR020636
DomainWnt

WNT3 WNT3A

1.12e-0319492IPR005817
DomainWNT1

WNT3 WNT3A

1.12e-0319492SM00097
DomainWnt_CS

WNT3 WNT3A

1.12e-0319492IPR018161
Domainwnt

WNT3 WNT3A

1.12e-0319492PF00110
DomainWNT1

WNT3 WNT3A

1.12e-0319492PS00246
DomainSH3_9

RIMBP3 RIMBP3C RIMBP3B

1.12e-0378493PF14604
DomainSH3_2

RIMBP3 RIMBP3C RIMBP3B

1.49e-0386493IPR011511
DomainSH3_2

RIMBP3 RIMBP3C RIMBP3B

1.49e-0386493PF07653
PathwayREACTOME_CAMK_IV_MEDIATED_PHOSPHORYLATION_OF_CREB

CAMK2A CAMK2D CAMK2G

1.14e-0610313M26910
PathwayKEGG_MELANOGENESIS

CAMK2A CAMK2D WNT3 CAMK2G WNT3A

2.50e-06101315M7761
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_EGFR_TO_PLCG_CAMK_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

3.45e-0614313M47386
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_PLCG_CAMK_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

3.45e-0614313M47388
PathwayWP_WNT_SIGNALING_PATHWAY

CAMK2A CAMK2D WNT3 CAMK2G WNT3A

3.82e-06110315MM15977
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_CAMK_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

4.30e-0615313M47385
PathwayWP_WNT_SIGNALING_WP428

CAMK2A CAMK2D WNT3 CAMK2G WNT3A

4.36e-06113315M39669
PathwayKEGG_MEDICUS_REFERENCE_PDGF_PDGFR_PLCG_CAMK_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

6.41e-0617313M47387
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_CAMK_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

9.11e-0619313M47957
PathwayREACTOME_INTERFERON_GAMMA_SIGNALING

CAMK2A CAMK2D CAMK2G

9.11e-0619313MM15473
PathwayREACTOME_RAS_ACTIVATION_UPON_CA2_INFLUX_THROUGH_NMDA_RECEPTOR

CAMK2A CAMK2D CAMK2G

1.07e-0520313M17670
PathwayREACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION

CAMK2A CAMK2D CAMK2G

1.25e-0521313M838
PathwayREACTOME_NEGATIVE_REGULATION_OF_NMDA_RECEPTOR_MEDIATED_NEURONAL_TRANSMISSION

CAMK2A CAMK2D CAMK2G

1.25e-0521313M27944
PathwayREACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION

CAMK2A CAMK2D CAMK2G

1.44e-0522313MM15104
PathwayREACTOME_HSF1_DEPENDENT_TRANSACTIVATION

CAMK2A CAMK2D CAMK2G

1.66e-0523313MM14953
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_ATP2B3_TO_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

1.66e-0523313M47512
PathwayREACTOME_LONG_TERM_POTENTIATION

CAMK2A CAMK2D CAMK2G

1.66e-0523313M27949
PathwayKEGG_WNT_SIGNALING_PATHWAY

CAMK2A CAMK2D WNT3 CAMK2G WNT3A

1.79e-05151315M19428
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_CACNA1D_H_TO_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

1.89e-0524313M47509
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KCNJ5_TO_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

2.14e-0525313M47510
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_ATP1A1_TO_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

2.14e-0525313M47511
PathwayKEGG_MEDICUS_REFERENCE_ANGIOTENSIN_ALDOSTERONE_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

3.04e-0528313M47508
PathwayREACTOME_CREB1_PHOSPHORYLATION_THROUGH_NMDA_RECEPTOR_MEDIATED_ACTIVATION_OF_RAS_SIGNALING

CAMK2A CAMK2D CAMK2G

3.04e-0528313M837
PathwayREACTOME_TRAFFICKING_OF_AMPA_RECEPTORS

CAMK2A CAMK2D CAMK2G

3.38e-0529313MM15028
PathwayREACTOME_TRAFFICKING_OF_AMPA_RECEPTORS

CAMK2A CAMK2D CAMK2G

4.15e-0531313M7223
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

CAMK2A CAMK2D CAMK2G

4.57e-0532313M27455
PathwayREACTOME_REGULATION_OF_MECP2_EXPRESSION_AND_ACTIVITY

CAMK2A CAMK2D CAMK2G

4.57e-0532313M27900
PathwayWP_DISRUPTION_OF_POSTSYNAPTIC_SIGNALING_BY_CNV

CAMK2A CAMK2D CAMK2G

5.02e-0533313M39875
PathwayREACTOME_RAF_ACTIVATION

CAMK2A CAMK2D CAMK2G

5.50e-0534313M27556
PathwayREACTOME_RAF_ACTIVATION

CAMK2A CAMK2D CAMK2G

6.01e-0535313MM15271
PathwayREACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS

CAMK2A CAMK2D CAMK2G

6.01e-0535313MM15109
PathwayREACTOME_CA_DEPENDENT_EVENTS

CAMK2A CAMK2D CAMK2G

7.11e-0537313M749
PathwayREACTOME_HSF1_DEPENDENT_TRANSACTIVATION

CAMK2A CAMK2D CAMK2G

7.71e-0538313M27255
PathwayPID_IFNG_PATHWAY

CAMK2A CAMK2D CAMK2G

9.00e-0540313M161
PathwayREACTOME_DAG_AND_IP3_SIGNALING

CAMK2A CAMK2D CAMK2G

9.70e-0541313M512
PathwayWP_RENINANGIOTENSINALDOSTERONE_SYSTEM_RAAS

CAMK2A CAMK2D CAMK2G

1.20e-0444313M39845
PathwayREACTOME_ASSEMBLY_AND_CELL_SURFACE_PRESENTATION_OF_NMDA_RECEPTORS

CAMK2A CAMK2D CAMK2G

1.20e-0444313M27934
PathwayREACTOME_SIGNALING_BY_MODERATE_KINASE_ACTIVITY_BRAF_MUTANTS

CAMK2A CAMK2D CAMK2G

1.28e-0445313M27623
PathwayWP_NOCGMPPKG_MEDIATED_NEUROPROTECTION

CAMK2A CAMK2D CAMK2G

1.46e-0447313M39531
PathwayREACTOME_ION_HOMEOSTASIS

CAMK2A CAMK2D CAMK2G

2.21e-0454313M27460
PathwayREACTOME_ION_HOMEOSTASIS

CAMK2A CAMK2D CAMK2G

2.21e-0454313MM15202
PathwayREACTOME_G_PROTEIN_MEDIATED_EVENTS

CAMK2A CAMK2D CAMK2G

2.21e-0454313M26911
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

CAMK2A CAMK2D CAMK2G

2.34e-0455313M971
PathwayREACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES

CAMK2A CAMK2D CAMK2G

2.60e-0457313MM15643
PathwayWP_WNT_SIGNALING

WNT3 WNT3A PAFAH1B1

3.18e-0461313MM15893
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_MECP2

CAMK2A CAMK2D CAMK2G

3.50e-0463313M27862
PathwayREACTOME_SIGNALING_BY_BRAF_AND_RAF1_FUSIONS

CAMK2A CAMK2D CAMK2G

3.84e-0465313M38994
PathwayKEGG_GLIOMA

CAMK2A CAMK2D CAMK2G

3.84e-0465313M1835
PathwayKEGG_LONG_TERM_POTENTIATION

CAMK2A CAMK2D CAMK2G

4.77e-0470313M3115
PathwayREACTOME_ION_CHANNEL_TRANSPORT

CAMK2A CAMK2D CAMK2G ANO7

5.68e-04176314MM15718
PathwayWP_NONGENOMIC_ACTIONS_OF_125_DIHYDROXYVITAMIN_D3

CAMK2A CAMK2D CAMK2G

5.84e-0475313M39568
PathwayREACTOME_ION_CHANNEL_TRANSPORT

CAMK2A CAMK2D CAMK2G ANO7

6.57e-04183314M997
PathwayREACTOME_SIGNALING_BY_GPCR

CAMK2A CAMK2D WNT3 CAMK2G WNT3A RLN3 EDN2

6.79e-04702317M746
PathwayREACTOME_ONCOGENIC_MAPK_SIGNALING

CAMK2A CAMK2D CAMK2G

7.58e-0482313M27626
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_ACYLATION

WNT3 WNT3A

7.82e-0419312M47836
PathwayKEGG_ERBB_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

9.01e-0487313M12467
PathwayREACTOME_OPIOID_SIGNALLING

CAMK2A CAMK2D CAMK2G

9.94e-0490313M6467
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

CAMK2A CAMK2D CAMK2G

1.06e-0392313MM14951
PathwayWP_ERBB_SIGNALING

CAMK2A CAMK2D CAMK2G

1.06e-0392313M39715
PathwayREACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS

CAMK2A CAMK2D CAMK2G

1.13e-0394313M2843
PathwayREACTOME_INTERFERON_GAMMA_SIGNALING

CAMK2A CAMK2D CAMK2G

1.27e-0398313M965
PathwayREACTOME_WNT_LIGAND_BIOGENESIS_AND_TRAFFICKING

WNT3 WNT3A

1.36e-0325312MM14940
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

CAMK2A CAMK2D CAMK2G

1.39e-03101313M27253
PathwayKEGG_GNRH_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

1.39e-03101313M1979
PathwayWP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY

WNT3 WNT3A PAFAH1B1

1.39e-03101313MM15829
PathwayWP_WNT_SIGNALING_AND_PLURIPOTENCY

WNT3 WNT3A PAFAH1B1

1.39e-03101313M39387
PathwayREACTOME_CARDIAC_CONDUCTION

CAMK2A CAMK2D CAMK2G

1.47e-03103313MM15196
PathwayREACTOME_WNT_LIGAND_BIOGENESIS_AND_TRAFFICKING

WNT3 WNT3A

1.47e-0326312M27239
PathwayPID_WNT_SIGNALING_PATHWAY

WNT3 WNT3A

1.71e-0328312M77
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_INHIBITOR

WNT3 WNT3A

1.71e-0328312M47835
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PTCH1_TO_HEDGEHOG_SIGNALING_PATHWAY

WNT3 WNT3A

1.83e-0329312M47372
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_SMO_TO_HEDGEHOG_SIGNALING_PATHWAY

WNT3 WNT3A

1.83e-0329312M47377
PathwayWP_1P36_COPY_NUMBER_VARIATION_SYNDROME

MXRA8 PEX10 KLHL17

1.87e-03112313M48072
PathwayKEGG_OOCYTE_MEIOSIS

CAMK2A CAMK2D CAMK2G

1.91e-03113313M16817
PathwayKEGG_NEUROTROPHIN_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

2.61e-03126313M16763
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

WNT3 WNT3A

2.81e-0336312M39699
PathwayREACTOME_CARDIAC_CONDUCTION

CAMK2A CAMK2D CAMK2G

2.85e-03130313M27454
PathwayKEGG_MEDICUS_VARIANT_FZD7_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

WNT3 WNT3A

2.97e-0337312M47411
PathwayREACTOME_INTERFERON_SIGNALING

CAMK2A CAMK2D CAMK2G

3.38e-03138313MM15635
PathwayWP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING

CAMK2A CAMK2D CAMK2G

3.52e-03140313M42572
PathwayREACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION

CAMK2A CAMK2D CAMK2G

3.81e-03144313MM14501
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

CAMK2A CAMK2D CAMK2G

4.03e-03147313MM15854
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

WNT3 WNT3A

4.18e-0344312MM15878
PathwayWP_CALCIUM_REGULATION_IN_CARDIAC_CELLS

CAMK2A CAMK2D CAMK2G

4.35e-03151313M39329
PathwayKEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

WNT3 WNT3A

4.37e-0345312M47412
PathwayWP_MESODERMAL_COMMITMENT_PATHWAY

TRIM28 WNT3 WNT3A

4.51e-03153313M39546
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY

WNT3 WNT3A

4.56e-0346312M47409
PathwayWP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS

CAMK2A CAMK2D CAMK2G

4.59e-03154313MM15974
PathwayWP_CANCER_PATHWAYS

CAMK2A CAMK2D WNT3 CAMK2G WNT3A

4.62e-03507315M48302
PathwayREACTOME_G_ALPHA_I_SIGNALLING_EVENTS

CAMK2A CAMK2D CAMK2G RLN3

4.73e-03314314M600
PathwayWP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS

CAMK2A CAMK2D CAMK2G

4.76e-03156313M39475
PathwayREACTOME_MUSCLE_CONTRACTION

CAMK2A CAMK2D CAMK2G

5.56e-03165313MM15026
PathwayKEGG_BASAL_CELL_CARCINOMA

WNT3 WNT3A

6.46e-0355312M17807
PathwayKEGG_HEDGEHOG_SIGNALING_PATHWAY

WNT3 WNT3A

6.69e-0356312M1053
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

CAMK2A CAMK2D CAMK2G

6.86e-03178313M2890
Pubmed

RIM-BP3 is a manchette-associated protein essential for spermiogenesis.

RIMBP3 RIMBP3C RIMBP3B

1.34e-08453319091768
Pubmed

Cadmium activates CaMK-II and initiates CaMK-II-dependent apoptosis in mesangial cells.

CAMK2A CAMK2D CAMK2G

1.34e-08453317367784
Pubmed

Developmental expression of the CaM kinase II isoforms: ubiquitous gamma- and delta-CaM kinase II are the early isoforms and most abundant in the developing nervous system.

CAMK2A CAMK2D CAMK2G

1.34e-08453310381553
Pubmed

[Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions].

CAMK2A CAMK2D CAMK2G

1.34e-08453311889801
Pubmed

Calmodulin kinase II attenuation of gene transcription by preventing cAMP response element-binding protein (CREB) dimerization and binding of the CREB-binding protein.

CAMK2A CAMK2D CAMK2G

3.33e-08553311013247
Pubmed

Alpha-kinase anchoring protein alphaKAP interacts with SERCA2A to spatially position Ca2+/calmodulin-dependent protein kinase II and modulate phospholamban phosphorylation.

CAMK2A CAMK2D CAMK2G

3.33e-08553319671701
Pubmed

Structure and evolution of RIM-BP genes: identification of a novel family member.

RIMBP3 RIMBP3C RIMBP3B

3.33e-08553317855024
Pubmed

Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B.

CAMK2A CAMK2D CAMK2G

3.33e-08553316436603
Pubmed

Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure.

CAMK2A CAMK2D CAMK2G

3.33e-08553318218981
Pubmed

Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain.

CAMK2A CAMK2D CAMK2G

3.33e-08553321209221
Pubmed

Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II.

CAMK2A CAMK2D CAMK2G

3.33e-08553314722083
Pubmed

Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma.

CAMK2A CAMK2D CAMK2G

6.66e-08653311972023
Pubmed

Multiple kinases regulate mafA expression in the pancreatic beta cell line MIN6.

CAMK2A CAMK2D CAMK2G

6.66e-08653318948074
Pubmed

Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2.

CAMK2A CAMK2D CAMK2G

6.66e-08653316120608
Pubmed

ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion.

CAMK2A CAMK2D CAMK2G

1.16e-07753334932950
Pubmed

Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II.

CAMK2A CAMK2D CAMK2G

1.16e-0775339115241
Pubmed

Ca(2+)/CaM-dependent kinases: from activation to function.

CAMK2A CAMK2D CAMK2G

1.86e-07853311264466
Pubmed

Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.

CAMK2A CAMK2D CAMK2G

1.86e-07853320668654
Pubmed

Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle.

CAMK2A CAMK2D CAMK2G

2.79e-07953312660151
Pubmed

CaMKII Signaling Stimulates Mef2c Activity In Vitro but Only Minimally Affects Murine Long Bone Development in vivo.

CAMK2A CAMK2D CAMK2G

3.98e-071053328361052
Pubmed

The presence and activation of two essential transcription factors (cAMP response element-binding protein and cAMP-dependent transcription factor ATF1) in the two-cell mouse embryo.

CAMK2A CAMK2D CAMK2G

3.98e-071053319776387
Pubmed

PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-δ activation in mouse models of Down syndrome.

CAMK2A CAMK2D CAMK2G

5.47e-071153321491429
Pubmed

Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma.

CAMK2A CAMK2D CAMK2G

7.28e-07125338615909
Pubmed

Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle.

CAMK2A CAMK2D CAMK2G

7.28e-071253312815021
Pubmed

Developmental rearrangements of cortical glutamate-NMDA receptor binding sites in late human gestation.

CAMK2A CAMK2D CAMK2G

7.28e-07125338665664
Pubmed

Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.

RIMBP3 RIMBP3C RIMBP3B

1.20e-061453317662146
Pubmed

Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf.

CAMK2A CAMK2D CAMK2G

1.20e-061453310373510
Pubmed

The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1.

CAMK2A CAMK2D CAMK2G

1.50e-061553314622581
Pubmed

Adjacent asparagines in the NR2-subunit of the NMDA receptor channel control the voltage-dependent block by extracellular Mg2+.

CAMK2A CAMK2D CAMK2G

1.50e-06155339481670
Pubmed

Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45.

WNT3 WNT3A

2.28e-06253211788904
Pubmed

Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3).

PEG3 ZIM2

2.28e-06253210708526
Pubmed

Molecular mechanism of dynein-dynactin complex assembly by LIS1.

PAFAH1B1 MAPK8IP3

2.28e-06253238547289
Pubmed

[PI3K/Akt/Erk signaling pathway mediates neuroprotection of CaMKⅡγ and CaMKⅡδ against ischemic reperfusion injury in mice].

CAMK2D CAMK2G

2.28e-06253238597448
Pubmed

CaMKII is essential for the function of the enteric nervous system.

CAMK2A CAMK2G

2.28e-06253222952977
Pubmed

Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload.

CAMK2A CAMK2D

2.28e-06253221252154
Pubmed

CaM kinase II regulates cardiac hemoglobin expression through histone phosphorylation upon sympathetic activation.

CAMK2D CAMK2G

2.28e-06253231619570
Pubmed

Ischemic Injury-Induced CaMKIIδ and CaMKIIγ Confer Neuroprotection Through the NF-κB Signaling Pathway.

CAMK2D CAMK2G

2.28e-06253229992531
Pubmed

Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube.

WNT3 WNT3A

2.28e-0625322001840
Pubmed

Alterations of L-type calcium current and cardiac function in CaMKII{delta} knockout mice.

CAMK2A CAMK2D

2.28e-06253220538682
Pubmed

Ca2+/calmodulin-dependent protein kinase II-γ (CaMKIIγ) negatively regulates vascular smooth muscle cell proliferation and vascular remodeling.

CAMK2D CAMK2G

2.28e-06253226567004
Pubmed

Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance.

CAMK2D CAMK2G

2.28e-06253234303021
Pubmed

Virus-Mediated Genome Editing via Homology-Directed Repair in Mitotic and Postmitotic Cells in Mammalian Brain.

ZBTB20 CAMK2A

2.28e-06253229056297
Pubmed

Cardiac CaM Kinase II genes δ and γ contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy.

CAMK2D CAMK2G

2.28e-06253225124496
Pubmed

CaM Kinase II mediates maladaptive post-infarct remodeling and pro-inflammatory chemoattractant signaling but not acute myocardial ischemia/reperfusion injury.

CAMK2D CAMK2G

2.28e-06253225193973
Pubmed

Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation.

CAMK2A CAMK2D CAMK2G

2.68e-061853318311135
Pubmed

Identification of novel human tumor cell-specific CaMK-II variants.

CAMK2D CAMK2G

6.83e-0635329060999
Pubmed

Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells.

CAMK2D CAMK2G

6.83e-06353210819240
Pubmed

Pressure overload selectively up-regulates Ca2+/calmodulin-dependent protein kinase II in vivo.

CAMK2A CAMK2G

6.83e-06353212554746
Pubmed

CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling.

CAMK2A CAMK2G

6.83e-06353223502535
Pubmed

The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1.

CAMK2A CAMK2D

6.83e-06353234558218
Pubmed

Calcium/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy.

CAMK2D CAMK2G

6.83e-06353225489064
Pubmed

Crucial role for Ca2(+)/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation.

CAMK2D CAMK2G

6.83e-06353223283722
Pubmed

CaMKII-δ9 promotes cardiomyopathy through disrupting UBE2T-dependent DNA repair.

CAMK2A CAMK2G

6.83e-06353231481791
Pubmed

Wnt-3a and Wnt-3 differently stimulate proliferation and neurogenesis of spinal neural precursors and promote neurite outgrowth by canonical signaling.

WNT3 WNT3A

6.83e-06353220722074
Pubmed

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway.

CAMK2A CAMK2G

6.83e-06353225246560
Pubmed

Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin.

WNT3 WNT3A

6.83e-06353226902720
Pubmed

The multifunctional Ca2+/calmodulin-dependent kinase II regulates vascular smooth muscle migration through matrix metalloproteinase 9.

CAMK2A CAMK2D

6.83e-06353222427508
Pubmed

CaMKII Serine 280 O-GlcNAcylation Links Diabetic Hyperglycemia to Proarrhythmia.

CAMK2D CAMK2G

6.83e-06353233926209
Pubmed

Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase.

CAMK2A CAMK2G

6.83e-0635321309762
Pubmed

Calcium/calmodulin kinase II-dependent acetylcholine receptor cycling at the mammalian neuromuscular junction in vivo.

CAMK2D CAMK2G

6.83e-06353220844140
Pubmed

Crystal structure of a mammalian Wnt-frizzled complex.

WNT3 WNT3A

6.83e-06353231036956
Pubmed

Ca2+/calmodulin-dependent kinase II phosphorylates the epidermal growth factor receptor on multiple sites in the cytoplasmic tail and serine 744 within the kinase domain to regulate signal generation.

CAMK2A CAMK2G

6.83e-06353210347170
Pubmed

Phosphorylation of Serine 235 of the Hepatitis C Virus Non-Structural Protein NS5A by Multiple Kinases.

CAMK2D CAMK2G

6.83e-06353227875595
Pubmed

Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.

CAMK2A CAMK2G

6.83e-06353219603549
Pubmed

Calcium/calmodulin-dependent protein kinase II and calmodulin: regulators of the meiotic spindle in mouse eggs.

CAMK2A CAMK2G

6.83e-0635329882483
Pubmed

Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance.

CAMK2A CAMK2G

6.83e-06353223516528
Pubmed

Essentiality of Regulator of G Protein Signaling 6 and Oxidized Ca2+/Calmodulin-Dependent Protein Kinase II in Notch Signaling and Cardiovascular Development.

CAMK2D CAMK2G

6.83e-06353229079565
Pubmed

Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity.

CAMK2A CAMK2G

1.36e-05453222503562
Pubmed

Wnt signaling controls the timing of oligodendrocyte development in the spinal cord.

WNT3 WNT3A

1.36e-05453215950605
Pubmed

CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury.

CAMK2A CAMK2D

1.36e-05453224949568
Pubmed

KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors.

ZBTB20 WNT3 WNT3A

1.46e-053153337838801
Pubmed

Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice.

CAMK2A WNT3 WNT3A

1.93e-053453328069946
Pubmed

Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin.

CAMK2A CAMK2G

2.27e-05553211160423
Pubmed

Phosphorylation of 69-kDa choline acetyltransferase at threonine 456 in response to amyloid-beta peptide 1-42.

CAMK2A CAMK2G

2.27e-05553212486117
Pubmed

Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex.

WNT3 WNT3A

2.27e-05553215143193
Pubmed

Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein.

CAMK2A CAMK2G

2.27e-0555328663317
Pubmed

PTENα Modulates CaMKII Signaling and Controls Contextual Fear Memory and Spatial Learning.

CAMK2A CAMK2G

2.27e-05553228636948
Pubmed

Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli.

WNT3 WNT3A

2.27e-05553218716223
Pubmed

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response.

WNT3 WNT3A

3.40e-05653210557084
Pubmed

A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo.

WNT3 WNT3A

3.40e-05653214723853
Pubmed

A β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice.

CAMK2A CAMK2D

3.40e-05653220877009
Pubmed

Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue.

WNT3 WNT3A

3.40e-0565328168088
Pubmed

Exploring the formation mechanism of short-tailed phenotypes in animals using mutant mice with the TBXT gene c.G334T developed by CRISPR/Cas9.

WNT3 WNT3A

3.40e-05653238401832
Pubmed

Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II.

CAMK2A CAMK2G

3.40e-05653211027280
Pubmed

Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate.

WNT3 WNT3A

4.76e-05753218413325
Pubmed

Dishevelled-2 docks and activates Src in a Wnt-dependent manner.

WNT3 WNT3A

4.76e-05753219920076
Pubmed

Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.

CAMK2A WNT3 WNT3A

5.17e-054753318351675
Pubmed

Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome.

CAMK2A CAMK2D CAMK2G

5.86e-054953327352031
Pubmed

Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin.

WNT3 WNT3A

8.15e-05953216890161
Pubmed

Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation.

WNT3 WNT3A

8.15e-05953218986540
Pubmed

Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds.

WNT3 WNT3A

1.02e-04105328275860
Pubmed

The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.

WNT3 WNT3A

1.02e-041053210866835
Pubmed

Aberrantly activated Wnt/β-catenin pathway co-receptors LRP5 and LRP6 regulate osteoblast differentiation in the developing coronal sutures of an Apert syndrome (Fgfr2S252W/+ ) mouse model.

WNT3 WNT3A

1.02e-041053232822074
Pubmed

An evolutionarily conserved Lhx2-Ldb1 interaction regulates the acquisition of hippocampal cell fate and regional identity.

ZBTB20 WNT3A

1.02e-041053232994168
Pubmed

Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53.

CAMK2A CAMK2G

1.02e-041053217568776
Pubmed

Multiple and cooperative phosphorylation events regulate the CREM activator function.

CAMK2D CAMK2G

1.24e-04115328404858
Pubmed

Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development.

WNT3 WNT3A

1.49e-041253221246653
Pubmed

Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway.

WNT3 WNT3A

1.49e-041253219690384
Pubmed

Gene trap screening as an effective approach for identification of Wnt-responsive genes in the mouse embryo.

WNT3 WNT3A

1.49e-041253215778975
Pubmed

The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking.

CAMK2A CAMK2D CAMK2G PAFAH1B1

1.56e-0417753426485645
InteractionCAMK2N1 interactions

CAMK2A CAMK2D CAMK2G

1.92e-0610523int:CAMK2N1
InteractionDACT2 interactions

ZBTB20 CAMK2D CAMK2G

8.86e-0616523int:DACT2
Cytoband19q13.4

TRIM28 PEG3 ZIM2

1.08e-047953319q13.4
Cytoband22q11.21

RIMBP3 RIMBP3C RIMBP3B

2.95e-0411153322q11.21
Cytoband3q13.2

ZBTB20 SPICE1

5.95e-04315323q13.2
Cytoband7p22.1

RSPH10B2 RSPH10B

1.37e-03475327p22.1
Cytoband14q23.1

TOMM20L CCDC175

1.37e-034753214q23.1
CytobandEnsembl 112 genes in cytogenetic band chr22q11

RIMBP3 RIMBP3C RIMBP3B RGL4

1.41e-03419534chr22q11
CytobandEnsembl 112 genes in cytogenetic band chr3q13

ADPRH ZBTB20 SPICE1

2.16e-03221533chr3q13
CytobandEnsembl 112 genes in cytogenetic band chr7p12

VWC2 PKD1L1-AS1

2.44e-0363532chr7p12
Cytoband1p36.33

MXRA8 KLHL17

3.62e-03775321p36.33
CytobandEnsembl 112 genes in cytogenetic band chr9p24

ERMP1 CDC37L1

6.62e-03105532chr9p24
GeneFamilyWnt family|Endogenous ligands

WNT3 WNT3A

3.62e-0419272360
GeneFamilyEndogenous ligands

WNT3 WNT3A RLN3 EDN2

3.99e-04237274542
ToppCellsaliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LSR MISP CAMK2D GALNT12 ERMP1

3.70e-06197535d6c9da7a3a6d2bcb13e2fc6605c8a59e7fb121c5
ToppCellsaliva-Severe-critical_progression_d28-40-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LSR MISP CAMK2D GALNT12 ERMP1

3.70e-0619753580b05c8ad9c1edc5dea3236079372475431343fe
Diseaseheart conduction disease (implicated_via_orthology)

CAMK2A CAMK2D CAMK2G

1.39e-0532433DOID:10273 (implicated_via_orthology)
Diseaseperoxisomal disease (implicated_via_orthology)

ACBD5 PEX10

3.10e-056432DOID:906 (implicated_via_orthology)
Diseaseanorectal malformation

UROC1 KLHL17

3.49e-0419432MONDO_0019938
DiseaseChagas cardiomyopathy

SYT9 ANKRD18B

1.89e-0344432EFO_0005529
Diseaseaggressive behaviour measurement, ADHD symptom measurement

WNT3 CAMK2G

4.45e-0368432EFO_0007826, EFO_0007860
Diseaseaortic measurement

CAMK2A CCDC175 EDN2

5.84e-03251433EFO_0020865

Protein segments in the cluster

PeptideGeneStartEntry
LAMRREGEETHLWSR

MAMDC4

741

Q6UXC1
ISDHWIRMRSQEGRP

COPS6

51

Q7L5N1
RGQHWQLEMADTRSV

ACBD5

26

Q5T8D3
WRADDVSRHETMGSN

ANKRD18B

456

A2A2Z9
MESVEHRRSVGRWEA

CFAP46

2521

Q8IYW2
QQEAMREPRSTHSRW

EDN2

161

P20800
WNEATERHQERRTQM

PKD1L1-AS1

71

Q9H7B7
MEWGSESAAVRRHRV

ERMP1

1

Q7Z2K6
AEMEVGTEQTDRRWR

RIMBP3B

1516

A6NNM3
AEMEVGTEQTDRRWR

RIMBP3C

1516

A6NJZ7
RWRRSDILAHEAMGD

RLN3

51

Q8WXF3
TGHREWVRMVRPNQD

PAFAH1B1

231

P43034
ARRWMRHHTATLTEQ

PEX10

141

O60683
QDSAARDRTDMHRTW

ANO7

126

Q6IWH7
RDRTDMHRTWRETFL

ANO7

131

Q6IWH7
RHGEGRMRWLTTNEE

RSPH10B

236

P0C881
RHGEGRMRWLTTNEE

RSPH10B2

236

B2RC85
RVTRHKNAMAERWES

MISP

656

Q8IVT2
WTEMIRASREHPSVQ

MAPK8IP3

551

Q9UPT6
WTSSRVDHVMDSVAR

NEIL3

301

Q8TAT5
HRMSGGRQEEFRTWL

FBXO31

236

Q5XUX0
TVAHDVSARDWQMRR

FAHD2A

186

Q96GK7
EVTPGDRSWHQMVVR

HSH2D

301

Q96JZ2
SRDMEPRDRWSHTRN

PEG3

171

Q9GZU2
SMRARDRARVVEHWI

RGL4

286

Q8IZJ4
TDRWHVVASMSTRRA

KLHL17

366

Q6TDP4
ERDEKMQHVSTWLRG

CCDC175

736

P0C221
TQHGEEFRRMLDGRW

DHX58

61

Q96C10
TWHTVPERERIRMQS

GALNT12

286

Q8IXK2
RWHRVAVSIDGEMVT

COL5A3

146

P25940
TSQSEETRVWHRRDG

CAMK2G

526

Q13555
IRHFGMLSRWDDSQR

CDC37L1

166

Q7L3B6
TMQSEETRVWHRRDG

CAMK2D

446

Q13557
MSEVTSLHEDDWRSR

LSR

431

Q86X29
WAGTREEVRDMSEHV

PAGE5

11

Q96GU1
EAERLGRDHWSEMLS

SYT9

461

Q86SS6
QDSLTRWHRMRGETT

VARS1

361

P26640
AEMEVGTEQTDRRWR

RIMBP3

1516

Q9UFD9
HARRLAEDDWTGMES

SNUPN

61

O95149
TAQSEETRVWHRRDG

CAMK2A

446

Q9UQM7
TQRWRVSHMGEDLEN

SPICE1

601

Q8N0Z3
LDVGRWRVSDDTVMH

ADPRH

46

P54922
EGTWRIERQAMCTRH

VWC2

306

Q2TAL6
HRQGWLMEVTDSLDR

UROC1

281

Q96N76
TDGSHWLSMREALRD

UGT1A5

36

P35504
ASEMVVEKHRESRGW

WNT3

241

P56703
SRWNVHVRTGITEEM

TECPR2

1286

O15040
ARQDWEQTVEMGHRI

TTC21A

226

Q8NDW8
SWITRIHERSQQMER

ZBTB20

286

Q9HC78
SRDMEPRDRWSHTRN

ZIM2

46

Q9NZV7
MVVEKHRESRGWVET

WNT3A

241

P56704
QEVRMGELWLSRGEH

TOMM20L

76

Q6UXN7
TEGQQERLERQHWTM

TRIM28

321

Q13263
SPRMVWTQDRLHDRQ

MXRA8

56

Q9BRK3