Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontau-protein kinase activity

BRSK2 PHKG1 PHKG2 BRSK1

3.89e-0822324GO:0050321
GeneOntologyMolecularFunctionphosphorylase kinase activity

PHKG1 PHKG2

1.49e-054322GO:0004689
GeneOntologyMolecularFunctionprotein kinase activity

BRSK2 PHKG1 PHKG2 SRPK2 RIPK4 FGFR2 BRSK1

3.74e-05600327GO:0004672
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

BRSK2 PHKG1 PHKG2 SRPK2 RIPK4 BRSK1

6.65e-05446326GO:0004674
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

BRSK2 PHKG1 PHKG2 SRPK2 RIPK4 FGFR2 BRSK1

1.07e-04709327GO:0016773
GeneOntologyMolecularFunctionkinase activity

BRSK2 PHKG1 PHKG2 SRPK2 RIPK4 FGFR2 BRSK1

1.70e-04764327GO:0016301
GeneOntologyMolecularFunctionprotein serine kinase activity

BRSK2 PHKG1 SRPK2 RIPK4 BRSK1

2.60e-04363325GO:0106310
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

BRSK2 PHKG1 PHKG2 SRPK2 RIPK4 FGFR2 BRSK1

5.92e-04938327GO:0016772
GeneOntologyMolecularFunctioncalcium/calmodulin-dependent protein kinase activity

PHKG1 PHKG2

8.52e-0427322GO:0004683
GeneOntologyMolecularFunctiontau protein binding

BRSK2 BRSK1

2.46e-0346322GO:0048156
GeneOntologyMolecularFunctionpeptidase activity

CD5L IMMP2L AGBL3 CAPN10 SENP5

3.59e-03654325GO:0008233
GeneOntologyMolecularFunctionendopeptidase activity

CD5L IMMP2L CAPN10 SENP5

4.73e-03430324GO:0004175
GeneOntologyMolecularFunction2-oxoglutarate-dependent dioxygenase activity

KDM6B HSPBAP1

4.86e-0365322GO:0016706
GeneOntologyBiologicalProcessmicrotubule cytoskeleton organization involved in establishment of planar polarity

BRSK2 BRSK1

6.13e-063302GO:0090176
GeneOntologyBiologicalProcesspositive regulation of glycogen catabolic process

PHKG1 PHKG2

3.06e-056302GO:0045819
GeneOntologyBiologicalProcesstissue morphogenesis

BRSK2 RIPK4 FGFR2 ANGPT1 BRSK1 KDM6B WLS

8.00e-05750307GO:0048729
GeneOntologyBiologicalProcessregulation of synaptic vesicle clustering

BRSK2 BRSK1

1.34e-0412302GO:2000807
GeneOntologyBiologicalProcesssynaptic vesicle localization

BRSK2 FGFR2 BRSK1

1.48e-0471303GO:0097479
GeneOntologyBiologicalProcessregulation of glycogen catabolic process

PHKG1 PHKG2

1.84e-0414302GO:0005981
GeneOntologyBiologicalProcessmesoderm formation

FGFR2 KDM6B WLS

2.28e-0482303GO:0001707
GeneOntologyBiologicalProcessmesoderm morphogenesis

FGFR2 KDM6B WLS

2.62e-0486303GO:0048332
GeneOntologyBiologicalProcessvasculogenesis involved in coronary vascular morphogenesis

FGFR2 ANGPT1

3.08e-0418302GO:0060979
GeneOntologyBiologicalProcesspeptidyl-amino acid modification

BRSK2 SRPK2 FGFR2 ANGPT1 BRSK1 AGBL3 SENP5

4.06e-04976307GO:0018193
GeneOntologyCellularComponentphosphorylase kinase complex

PHKG1 PHKG2

2.26e-055322GO:0005964
HumanPhenoAbsent radius

ESCO2 RIPK4 FGFR2

1.56e-0527103HP:0003974
HumanPhenoAbsent forearm bone

ESCO2 RIPK4 FGFR2

1.74e-0528103HP:0003953
HumanPhenoAplasia involving forearm bones

ESCO2 RIPK4 FGFR2

1.74e-0528103HP:0009822
HumanPhenoAplasia/Hypoplasia of the phalanges of the toes

RIPK4 FGFR2 WLS

3.76e-0536103HP:0010173
HumanPhenoBicornuate uterus

ESCO2 RIPK4 FGFR2

1.14e-0452103HP:0000813
HumanPhenoAbsent thumb

ESCO2 RIPK4 FGFR2

1.85e-0461103HP:0009777
HumanPhenoHypoplasia of the phalanges of the toes

FGFR2 WLS

2.27e-0412102HP:0010746
HumanPhenoCupped ear

RIPK4 FGFR2 WLS

2.67e-0469103HP:0000378
MousePhenoabnormal cranial synchondrosis

PFAS FGFR2

4.97e-056262MP:0030443
MousePhenopalatal shelf fusion with tongue or mandible

RIPK4 FGFR2

9.25e-058262MP:0009884
MousePhenoabnormal cranial cartilage development

PFAS FGFR2

1.19e-049262MP:0030467
DomainPhosph_kin_gamma

PHKG1 PHKG2

2.67e-062312IPR002291
DomainCa/CaM-dep_Ca-dep_prot_Kinase

BRSK2 PHKG1 PHKG2 BRSK1

4.98e-0669314IPR020636
DomainPROTEIN_KINASE_ATP

BRSK2 PHKG1 PHKG2 SRPK2 RIPK4 FGFR2 BRSK1

8.16e-06459317PS00107
DomainProt_kinase_dom

BRSK2 PHKG1 PHKG2 SRPK2 RIPK4 FGFR2 BRSK1

1.23e-05489317IPR000719
DomainPROTEIN_KINASE_DOM

BRSK2 PHKG1 PHKG2 SRPK2 RIPK4 FGFR2 BRSK1

1.30e-05493317PS50011
DomainSer/Thr_kinase_AS

BRSK2 PHKG1 PHKG2 SRPK2 RIPK4 BRSK1

2.30e-05357316IPR008271
DomainKinase-like_dom

BRSK2 PHKG1 PHKG2 SRPK2 RIPK4 FGFR2 BRSK1

2.39e-05542317IPR011009
DomainPROTEIN_KINASE_ST

BRSK2 PHKG1 PHKG2 SRPK2 RIPK4 BRSK1

2.49e-05362316PS00108
DomainProtein_kinase_ATP_BS

BRSK2 PHKG1 PHKG2 SRPK2 FGFR2 BRSK1

3.22e-05379316IPR017441
DomainPkinase

BRSK2 PHKG1 PHKG2 SRPK2 RIPK4 BRSK1

3.31e-05381316PF00069
DomainS_TKc

BRSK2 PHKG1 PHKG2 SRPK2 BRSK1

2.87e-04359315SM00220
DomainJMJC

KDM6B HSPBAP1

1.28e-0332312PS51184
DomainJmjC_dom

KDM6B HSPBAP1

1.28e-0332312IPR003347
DomainJmjC

KDM6B HSPBAP1

1.36e-0333312SM00558
PathwayREACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS

PHKG1 PHKG2

2.94e-0414262MM15391
PathwayREACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS

PHKG1 PHKG2

2.94e-0414262M19193
PathwayREACTOME_GLYCOGEN_METABOLISM

PHKG1 PHKG2

4.91e-0418262MM15577
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_CAMK_SIGNALING_PATHWAY

PHKG1 PHKG2

5.49e-0419262M47957
PathwayWP_ANGIOGENESIS

FGFR2 ANGPT1

8.81e-0424262M39556
PathwayREACTOME_GLYCOGEN_METABOLISM

PHKG1 PHKG2

9.56e-0425262M27857
Pubmed

Wntless is required for peripheral lung differentiation and pulmonary vascular development.

FGFR2 ANGPT1 WLS

7.98e-072032323523683
Pubmed

SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release.

BRSK2 BRSK1

8.20e-07232216630837
Pubmed

Elucidation of the molecular mechanisms underlying adverse reactions associated with a kinase inhibitor using systems toxicology.

PHKG1 PHKG2

8.20e-07232228725458
Pubmed

The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition.

PHKG1 PHKG2

8.20e-0723229362479
Pubmed

Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation.

BRSK2 BRSK1

8.20e-07232218339622
Pubmed

Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.

BRSK2 BRSK1

8.20e-07232230307479
Pubmed

Microtubule stabilization specifies initial neuronal polarization.

BRSK2 BRSK1

2.46e-06332218268107
Pubmed

Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells.

BRSK2 BRSK1

2.46e-06332222669945
Pubmed

Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity.

BRSK2 BRSK1

2.46e-06332220026642
Pubmed

Tuberous sclerosis complex proteins control axon formation.

BRSK2 BRSK1

4.92e-06432218794346
Pubmed

Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function.

BRSK2 BRSK1

8.19e-06532215150265
Pubmed

C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.

BRSK2 BRSK1

8.19e-06532218854318
Pubmed

Mammalian SAD kinases are required for neuronal polarization.

BRSK2 BRSK1

1.23e-05632215705853
Pubmed

SAD kinases control the maturation of nerve terminals in the mammalian peripheral and central nervous systems.

BRSK2 BRSK1

1.23e-05632224395778
Pubmed

Phosphorylation of microtubule-associated protein tau by AMPK-related kinases.

BRSK2 BRSK1

1.23e-05632221985311
Pubmed

LKB1 and AMPK regulate synaptic remodeling in old age.

BRSK2 BRSK1

1.23e-05632225086610
Pubmed

The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase.

PHKG1 PHKG2

2.29e-0583228999860
Pubmed

Wnt/Fgf crosstalk is required for the specification of basal cells in the mouse trachea.

FGFR2 WLS

4.49e-051132230696710
Pubmed

Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival.

BRSK2 BRSK1

5.38e-051232223275438
Pubmed

The loss of the kinases SadA and SadB results in early neuronal apoptosis and a reduced number of progenitors.

BRSK2 BRSK1

6.36e-051332229698519
Pubmed

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

BRSK2 BRSK1

8.55e-051532214976552
Pubmed

Angiogenic factors stimulate tubular branching morphogenesis of sonic hedgehog-deficient lungs.

FGFR2 ANGPT1

9.76e-051632217187775
Pubmed

Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.

RIPK4 PLEKHA8

1.11e-041732212747765
Pubmed

Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development.

FGFR2 ANGPT1

1.11e-041732216778080
Pubmed

LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.

BRSK2 BRSK1

1.39e-041932217482548
Pubmed

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.

BRSK2 BRSK1

1.54e-042032218227155
Pubmed

BMP-FGF signaling axis mediates Wnt-induced epidermal stratification in developing mammalian skin.

FGFR2 WLS

1.87e-042232225329657
Pubmed

SAD kinases sculpt axonal arbors of sensory neurons through long- and short-term responses to neurotrophin signals.

BRSK2 BRSK1

2.05e-042332223790753
Pubmed

A critical role for the protein kinase PKK in the maintenance of recirculating mature B cells and the development of B1 cells.

RIPK4 FGFR2

2.05e-042332226921474
Pubmed

Rhox8 homeobox gene ablation leads to rete testis abnormality and male subfertility in mice†.

CA14 FGFR2

2.24e-042432237471646
Pubmed

Single-cell transcriptomic signatures and gene regulatory networks modulated by Wls in mammalian midline facial formation and clefts.

FGFR2 WLS

2.84e-042732235781558
Pubmed

Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

FGFR2 ANGPT1

3.05e-042832218593464
Pubmed

Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.

ST8SIA2 WLS

3.51e-043032222837378
Pubmed

14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.

BRSK2 BRSK1

3.51e-043032216306228
Pubmed

Phase transition specified by a binary code patterns the vertebrate eye cup.

FGFR2 WLS

3.75e-043132234757798
Pubmed

STK11 is required for the normal program of ciliated cell differentiation in airways.

BRSK2 BRSK1

3.75e-043132231636950
Pubmed

Epicardial-myocardial signaling directing coronary vasculogenesis.

FGFR2 ANGPT1

5.35e-043732220299672
Pubmed

FOXL2 modulates cartilage, skeletal development and IGF1-dependent growth in mice.

FGFR2 IGFBP7

5.65e-043832226134413
Pubmed

Roles of tau protein in health and disease.

BRSK2 BRSK1

6.26e-044032228386764
Pubmed

Identification of genes expressed preferentially in the developing peripheral margin of the optic cup.

NINJ1 FGFR2

6.90e-044232219449303
Pubmed

The DNA sequence of human chromosome 7.

PHKG1 SRPK2 IMMP2L AGBL3

6.92e-0444132412853948
Cytoband19q13.12

HAUS5 ZNF585B

1.17e-037232219q13.12
Cytoband17p13.1

PFAS KDM6B

3.09e-0311832217p13.1
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

FGFR2 IGFBP7

9.82e-03161172593
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF142 ZNF513 ZNF585B

2.80e-0271817328
CoexpressionMIKKELSEN_NPC_ICP_WITH_H3K4ME3

PHKG2 SRPK2 ANGPT1 BRSK1 KDM6B ZNF585B

1.52e-05449326M2013
CoexpressionMIKKELSEN_NPC_ICP_WITH_H3K4ME3

PHKG2 SRPK2 ANGPT1 BRSK1 KDM6B ZNF585B

2.69e-05497326MM863
CoexpressionGSE360_L_DONOVANI_VS_B_MALAYI_LOW_DOSE_DC_UP

NINJ1 FGFR2 ANGPT1 KDM6B

9.81e-05199324M5203
CoexpressionGSE5503_LIVER_DC_VS_PLN_DC_ACTIVATED_ALLOGENIC_TCELL_UP

PHKG1 PHKG2 ANGPT1 KDM6B

9.81e-05199324M6992
CoexpressionGSE21670_TGFB_VS_IL6_TREATED_CD4_TCELL_UP

BRSK2 ST8SIA2 CD5L ZNF513

1.00e-04200324M7437
CoexpressionWAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D

ESCO2 NINJ1 ANGPT1 WLS IGFBP7 HELB

1.15e-04646326M2419
ToppCellfacs|World / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PFAS ANGPT1 KDM6B NSD3

6.67e-06171324c9990bc041a632b2f7bbebbfe737772c423d7027
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-BMP_responsible_cell|6m / Sample Type, Dataset, Time_group, and Cell type.

CA14 FGFR2 WLS IGFBP7

1.24e-052003245fb90118d3abc28d72bc483e68317255090a04c7
ToppCellP28-Hematopoietic-Erythroid-enucleate_erythrocyte|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ESCO2 CA14 PLEKHA8

2.89e-0583323c7ff56d4c7582fc497057cf3d5497fbd13c183cc
ToppCellP28-Hematopoietic-Erythroid|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ESCO2 CA14 PLEKHA8

2.89e-0583323e548e5c7b16c895b360a00f3d6fc1a7eb3d19294
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-OPC_related-Oligodendrocyte/OPC|GW26 / Sample Type, Dataset, Time_group, and Cell type.

CA14 FGFR2 KDM6B

1.28e-041373238ce463d1d74ac0ce80b812217d6bd76a788f14d2
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-OPC_related|GW26 / Sample Type, Dataset, Time_group, and Cell type.

CA14 FGFR2 KDM6B

1.28e-04137323264d5e06c37d1a9ef7748091b67d2a5aa803096e
ToppCellControl-Epithelial_alveolar-AT_1-AT2_Progenitor|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CA14 RIPK4 FGFR2

1.43e-0414232394e277f038f4006d99ff50222b0f5cf89bc3d46d
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

BRSK2 ANGPT1 HAUS5

1.52e-0414532342dd36c1bc2c43cfea7196e89f901e4ea2a403c7
ToppCellP28-Epithelial-epithelial_progenitor_cell-epi_progenitor|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

STPG3 FGFR2 BRSK1

1.85e-04155323be575a0096415705dba425002247289ff8f89474
ToppCellBac-SEP-Lymphocyte-T_NK-dnT|Bac-SEP / Disease, Lineage and Cell Type

IMMP2L PLEKHA8 ZNF585B

2.03e-04160323f5ca49801c981b903a85a64b21ece6b59fe91cbc
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_5|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PHKG1 KDM6B SENP5

2.07e-0416132378cc5bc488bc47726195a649946d414e6bfabf94
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like_Prolif-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

BRSK2 ESCO2 CA14

2.38e-041693232833a8a7094e4d407eb923f2bc59b9b112c6bae4
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 PHKG1 IGFBP7

2.60e-041743239f2e253694eb5860c00528fda31c305c6de8a2a1
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Radial_glial-RGCs_early_2|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

FGFR2 WLS IGFBP7

2.69e-041763238e0ac3ad5e47614b4befabd674a40e3eaae553f3
ToppCell3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ESCO2 PHKG1 IGFBP7

2.73e-0417732375cb2067a3f2d1b5a964890b02b604d1e79bd163
ToppCellfacs-Lung-EPCAM-3m-Epithelial-Alveolar_Epithelial_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIPK4 BRSK1 HSPBAP1

2.82e-0417932388dbec952507d84b85b08165eec80df99ed1e736
ToppCellfacs-Lung-EPCAM-3m-Epithelial-type_I_pneumocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIPK4 BRSK1 HSPBAP1

2.82e-04179323daf8189a22786171e2b629261cf720736aa4ebdb
ToppCellfacs-Marrow-KLS-3m-Hematologic-MPP_Fraction_B|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PFAS NINJ1 ANGPT1

2.96e-04182323e7138c8d3821b4141c4b1b23dab6d9b4e99fd4b2
ToppCell3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BRSK2 ANGPT1 IGFBP7

2.96e-041823231c1a687f728341c209b048b6715bcddd0ac20069
ToppCell3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response-SM_activated_stress_response_L.2.3.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BRSK2 ANGPT1 IGFBP7

2.96e-0418232397bb07478f56a937b490fba121ee603db64134a1
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D175|Adult / Lineage, Cell type, age group and donor

PFAS RIPK4 ZNF585B

2.96e-04182323ad4d74d8b19976e1ccc3c5ba8013199338cf6fd8
ToppCellHSPCs-Ery/Mk_prog.|HSPCs / Lineage and Cell class

NINJ1 ANGPT1 KDM6B

3.01e-0418332359cfb02143b6b54dfca7560562e064948f0340ca
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NINJ1 BRSK1 KDM6B

3.06e-04184323857ca1fc4de07b300839b22924211dc624453841
ToppCellPericytes-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

BRSK2 ANGPT1 IGFBP7

3.06e-04184323cd10d351d91a81dd6dc806cb4e0c8d7861c98e0b
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ST8SIA2 ANGPT1 IGFBP7

3.11e-04185323c85bba1210f1d389add3e40be9b96abac40cf8c1
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RIPK4 FGFR2 IMMP2L

3.16e-041863234e94158db52df41d71e67b02b9895a358eebee0f
ToppCellfacs-Skin-Telogen-3m-Epithelial-basal_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGFR2 WLS IL1RL2

3.21e-041873239c1013720c248ef201d010806b6e7ad24205e8ee
ToppCellE15.5-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PFAS FGFR2 KDM6B

3.21e-041873231288fcd0124c70711521f3ac83554e9acdd37cb2
ToppCellHSPCs-Ery/Mk_prog.|World / Lineage and Cell class

NINJ1 ANGPT1 KDM6B

3.26e-041883235390089213cd6ee90dcdfd3c3f5b6765376cccf2
ToppCell3'-Adult-Distal_Rectal-Mesenchymal-Pericytes|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BRSK2 ANGPT1 IGFBP7

3.31e-04189323d69b7a01dd4d6ad043bb6210e9ab34b49578389c
ToppCellfacs-Skin-nan-18m-Epithelial-Basal_IFE|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIPK4 KDM6B WLS

3.31e-041893236c71e81373cb7822de23c193a6350b6df9f567bc
ToppCell3'-Adult-Distal_Rectal-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BRSK2 ANGPT1 IGFBP7

3.31e-041893232b5f1b4f173a224342ea4f10b193ee33b7662699
ToppCell3'-Adult-Distal_Rectal-Mesenchymal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BRSK2 ANGPT1 IGFBP7

3.31e-0418932343e131458d8a4b120f7a5fb3d0c5650abded15f6
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_intermediate_(1)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RIPK4 FGFR2 IGFBP7

3.36e-04190323c95032bb3ee2b3d40fdf48016acb46d6f78a48a6
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

RIPK4 FGFR2 IGFBP7

3.36e-04190323625c08a0e5227efc46daa512fd579c3938ff76c7
ToppCelldroplet-Skin-nan-21m-Epithelial-basal_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGFR2 WLS IGFBP7

3.36e-04190323c1bfc1960a3df49c0f459454a7363804c32418ee
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Radial_glial-RGCs_early_2|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

CA14 ANGPT1 WLS

3.41e-0419132306107849463a1ccb78a5ccd3ae31619ef6bedda3
ToppCellPericytes|World / lung cells shred on cell class, cell subclass, sample id

BRSK2 ANGPT1 IGFBP7

3.46e-04192323057ad22b878c0c5fb59ed1412ca13db945c57a5a
ToppCelldroplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ST8SIA2 ANGPT1 BRSK1

3.52e-041933239d0b966d13cbce97beb43de6dc77f006c363a181
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ST8SIA2 ANGPT1 IGFBP7

3.52e-041933238d05805295c5d3aa93aeb38be5fbefa81e1be1f0
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ST8SIA2 ANGPT1 IGFBP7

3.52e-041933231b2cc627b2aa002b442358bd1188d470e67ce7d9
ToppCell356C-Myeloid-Monocyte-CD14+_Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

NINJ1 KDM6B IL1RL2

3.57e-041943233f9ac1de8605a7930f49a7ce0e32aea9997d7791
ToppCell356C-Myeloid-Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

NINJ1 KDM6B IL1RL2

3.57e-04194323a41cde3088b43670210daab4f43a24aa83dbd45b
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ST8SIA2 ANGPT1 IGFBP7

3.62e-04195323cbe518b465b4ef32797ae6b608219207c08493df
ToppCellPND07-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ST8SIA2 ANGPT1 IGFBP7

3.62e-04195323b616ee6f1d878935d293c8e0a8bbc5b4385301f0
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ST8SIA2 ANGPT1 IGFBP7

3.62e-041953231c1135be421af98cd0077bec1ff2c4158d42aa21
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESCO2 PFAS HAUS5

3.62e-04195323e9c7eb0b1a2d58f69b4e839665101948bd4527b8
ToppCellPND03-Mesenchymal-Mesenchymal_structural|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ST8SIA2 ANGPT1 IGFBP7

3.62e-04195323136b06b0931a69b1241101f68c01c44c70365fd9
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ST8SIA2 ANGPT1 IGFBP7

3.62e-041953231f005ee1da66b539bd200aaa98f46edbbc7f12e4
ToppCellPND10-Mesenchymal-Mesenchymal_structural-Fibroblastic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ST8SIA2 ANGPT1 IGFBP7

3.62e-0419532310f307aef8f4d9e71c501d5bcedb84d3be7a4d1b
ToppCellPND10-Mesenchymal-Mesenchymal_structural|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ST8SIA2 ANGPT1 IGFBP7

3.62e-0419532311d421bbbb71425d59cbdd673e052e00d5f0a768
ToppCellPND07-Mesenchymal-Mesenchymal_structural|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ST8SIA2 ANGPT1 IGFBP7

3.62e-041953232f9a274b26fc528a85f50933ec2f4db1dc9da0ca
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BRSK2 ANGPT1 IGFBP7

3.68e-04196323208ddedd29e1b9ca89cbb9b527c2e193a44cada2
ToppCell5'-Adult-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BRSK2 ANGPT1 IGFBP7

3.68e-04196323ce6f7ddb8104471dc90347f427486379914d63b4
ToppCell(5)_Fibroblast-K_(Pericytes)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

BRSK2 ANGPT1 IGFBP7

3.68e-04196323e3c89c5bd674289738d5590ebfd30c605f5156a5
ToppCell5'-Adult-SmallIntestine-Mesenchymal-Pericytes|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BRSK2 ANGPT1 IGFBP7

3.68e-041963236d7179decea512dd49bb2d5f6a4f5989349d52a9
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BRSK2 ANGPT1 IGFBP7

3.68e-0419632370b2e0b4ff4f1bc03fb72ace07a8a44f4b415922
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response-SM_activated_stress_response_L.2.3.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BRSK2 ANGPT1 IGFBP7

3.68e-04196323ac4c8571bd792538f8df7b9bdd90ef58405fd3b1
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ESCO2 CD5L BRSK1

3.73e-04197323d669d90c3f9e98b41bcbc49dbdc5698e0b42597c
ToppCell5'-Adult-LargeIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BRSK2 ANGPT1 IGFBP7

3.73e-04197323d16bb765afdc02406ffd7ce6a75bae72b66db66c
ToppCell5'-Adult-LargeIntestine-Mesenchymal-Pericytes|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BRSK2 ANGPT1 IGFBP7

3.73e-0419732368c23c23b6924892f4c238cf2f5abc7927e04fbc
ToppCell(3)_Chondrocytes-(34)_Chondro-progen|(3)_Chondrocytes / Cell class and subclass of bone marrow stroma cells in homeostatis

NINJ1 FGFR2 IGFBP7

3.73e-04197323012c49a57f9c2a3dfa988cd3882c8c6b7ef3a5ad
ToppCellcellseq-Mesenchymal-Myocytic-Myocytic_2-VSMC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

BRSK2 ANGPT1 IGFBP7

3.79e-04198323e967c601101361fc1c48dab0e5b76dc68813276e
ToppCell3'-Child09-12-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANGPT1 WLS IGFBP7

3.79e-04198323d83707b69fb64721ac3cff90ba58cdd999d6b386
ToppCellwk_08-11-Epithelial-Airway_epithelial_progenitor|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

RIPK4 FGFR2 IGFBP7

3.85e-04199323af664e0d41a889a75dbf6cf0d50acd26f5ab3a3a
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Smooth_muscle-2|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

BRSK2 ANGPT1 IGFBP7

3.85e-04199323706b7de777ff86eb22e538ccd5c2987ceb6be308
ToppCellParenchymal-10x3prime_v2-Stromal-Myofibroblastic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

BRSK2 ANGPT1 IGFBP7

3.85e-041993239a08c25bb4851ad4ac9db8916422280f71378c2c
ToppCellParenchyma_Control_(B.)-Stromal-TX-Smooth_muscle-2|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

BRSK2 ANGPT1 IGFBP7

3.85e-04199323471738f2059e20407572d9c4cbd11812068333ea
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NINJ1 CD5L KDM6B

3.85e-04199323e7faf7d0cb43cf93149c446e5f718f84fa85477c
ToppCellSepsis-Bac-SEP-Lymphocyte-T/NK-dn_T|Bac-SEP / Disease, condition lineage and cell class

IMMP2L PLEKHA8 ZNF585B

3.85e-041993234150a479b80596accf679b37aa9b0ac15cc132b2
ToppCellParenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

BRSK2 ANGPT1 IGFBP7

3.85e-041993232ed10c5e15c9d5ed0a8bea580842348d5698a07b
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Smooth_muscle-2-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

BRSK2 ANGPT1 IGFBP7

3.85e-04199323690a4f84b205532c4c9e5c19d5ae430d0655f421
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macrophage_intermediate|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

NINJ1 KDM6B IL1RL2

3.85e-04199323ccd473accf2205c120c0d32031619e421558a861
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW08-Stem_cells|GW08 / Sample Type, Dataset, Time_group, and Cell type.

ESCO2 PFAS FGFR2

3.90e-04200323691b3edf7d8449556e8bf611662eb85772959f0f
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW08-Stem_cells-Neuroepithelial_cell|GW08 / Sample Type, Dataset, Time_group, and Cell type.

ESCO2 PFAS FGFR2

3.90e-042003234e077aa7faddcebdfc54667f8b3990704441005b
ToppCellTracheal-10x5prime-Stromal-Fibroblastic-Fibro_immune_recruiting|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

BRSK2 ANGPT1 BRSK1

3.90e-04200323f692b602bc989d35c9162e73dda813dbef8d5267
ToppCellBrain_organoid-organoid_Tanaka_cellReport-3m-Mesenchymal-BMP_responsible_cell|3m / Sample Type, Dataset, Time_group, and Cell type.

CA14 WLS IGFBP7

3.90e-04200323a4b52466b6426a835655b5fe7487e15aea816e14
ToppCelldistal-mesenchymal-Airway_Smooth_Muscle-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

BRSK2 ANGPT1 IGFBP7

3.90e-04200323c69173892d80b8592233928cb207a3f4b533b4b4
ToppCelldistal-mesenchymal-Airway_Smooth_Muscle|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

BRSK2 ANGPT1 IGFBP7

3.90e-042003231b5ac5b3ddd4df32e940531cc020998f8cd95c2c
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW08-Stem_cells|GW08 / Sample Type, Dataset, Time_group, and Cell type.

ESCO2 PFAS FGFR2

3.90e-04200323d17ba4239e1fd702a3d757687110f0f2c6f91ef7
ToppCellBrain_organoid-organoid_Tanaka_cellReport-6m-Neuronal-Neuron|6m / Sample Type, Dataset, Time_group, and Cell type.

BRSK2 CA14 KDM6B

3.90e-04200323b5019b9d48f32cffd4645a5c0f3e0ac504ea8019
ToppCellBrain_organoid-organoid_Tanaka_cellReport-1m-Mesenchymal-BMP_responsible_cell|1m / Sample Type, Dataset, Time_group, and Cell type.

FGFR2 WLS IGFBP7

3.90e-0420032306d615fe4b7dd5128dbdcd510a5ff3eb480c61b2
ToppCellwk_08-11-Epithelial|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

RIPK4 FGFR2 IGFBP7

3.90e-04200323445fc7995ffc440c6256a6aab0bbf33fb0fea028
ToppCelldistal-1-mesenchymal-Airway_Smooth_Muscle|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

BRSK2 ANGPT1 IGFBP7

3.90e-042003234d4d227d4df7cab7293bc8005ca1b0441983f39a
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW08-Stem_cells-Stem_cells|GW08 / Sample Type, Dataset, Time_group, and Cell type.

ESCO2 PFAS FGFR2

3.90e-0420032336a110aa91a791fdf1142e7869e8aa0d342402d0
Drugholotoxins

ST8SIA2 RIPK4 CD5L

4.38e-0623323CID000119095
DrugTriflupromazine hydrochloride [1098-60-8]; Down 200; 10.2uM; MCF7; HT_HG-U133A

RIPK4 KDM6B NSD3 HAUS5 CAPN10

6.77e-061923257466_DN
DrugConvolamine hydrochloride [500-56-1]; Up 200; 11.8uM; HL60; HG-U133A

PFAS ZNF142 NSD3 CAPN10 SENP5

7.68e-061973251779_UP
DrugProglumide [6620-60-6]; Up 200; 12uM; PC3; HT_HG-U133A

CA14 FGFR2 ANGPT1 IGFBP7 NSD3

8.06e-061993254337_UP
DrugDAPH; Up 200; 10uM; PC3; HG-U133A

NINJ1 ZNF142 ANGPT1 KDM6B CAPN10

8.06e-06199325578_UP
DrugSAR 020106

BRSK2 BRSK1

4.00e-057322ctd:C547874
Diseaseserine/threonine-protein kinase BRSK2 measurement

BRSK2 BRSK1

3.20e-063312EFO_0803063
DiseaseIntellectual Disability

BRSK2 ZNF142 FGFR2 KDM6B CAPN10

9.58e-05447315C3714756
Diseaserenal cell carcinoma (is_marker_for)

PFAS ANGPT1 KDM6B

3.28e-04128313DOID:4450 (is_marker_for)
DiseaseMental Retardation, Psychosocial

FGFR2 KDM6B CAPN10

4.17e-04139313C0025363
DiseaseProfound Mental Retardation

FGFR2 KDM6B CAPN10

4.17e-04139313C0020796
DiseaseMental deficiency

FGFR2 KDM6B CAPN10

4.17e-04139313C0917816
Diseaseschizophrenia, anorexia nervosa

SRPK2 IMMP2L

1.17e-0348312MONDO_0005090, MONDO_0005351
Diseasetransitional cell carcinoma (is_marker_for)

FGFR2 ANGPT1

2.00e-0363312DOID:2671 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
AHHIGWQRIGDQIKY

AGBL3

251

Q8NEM8
GHYVNGKWLKPEHRN

ALDH16A1

41

Q8IZ83
HYQAVGLHLWKVEKR

CAPN10

416

Q9HC96
QNHGKLNGIKWHYFK

ANGPT1

466

Q15389
HCKGRVEVKHQNQWY

CD5L

146

O43866
HKNRYVKVPRGHIWV

IMMP2L

106

Q96T52
EHRIGGYKVRNQHWS

FGFR2

201

P21802
VWNLLHLEHKRNYGA

KDM6B

176

O15054
LEHIQKHIWYIGGKN

BRSK2

261

Q8IWQ3
AYGKTLRQHHGWVVR

PLEKHA8

436

Q96JA3
VKKIRGNLLWYGHQD

HAUS5

56

O94927
LIWNKVKRGHYGVQR

IGFBP7

191

Q16270
RLYGHWVKKGEQQNR

PHKG2

356

P15735
WRHGPINVNHYASKK

NINJ1

31

Q92982
IQYIKQKHGAIRWHG

IL1RL2

501

Q9HB29
RHWNAKYLSQVLHGK

HSPBAP1

56

Q96EW2
LEQIQKHPWYLGGKH

BRSK1

276

Q8TDC3
HHRFLEGIKYVGWKK

ESCO2

411

Q56NI9
RKYVAAQLHLHWGQK

CA14

101

Q9ULX7
VGKAGRQHWQHVYTA

HELB

901

Q8NG08
AFRIYGHWVKKGQQQ

PHKG1

351

Q16816
LHAVRGYWLTNKVHI

ST8SIA2

276

Q92186
GGFGQVYKVRHVHWK

RIPK4

31

P57078
TGHWDNYKRHQKVHG

ZNF513

481

Q8N8E2
HRQLVTKGYNGVKRW

SENP5

611

Q96HI0
YINGGKHWTHGHLRQ

STPG3

16

Q8N7X2
RHWFFKGQLHVDGQK

PFAS

231

O15067
HHLLKWIIKSNYQGL

SRPK2

171

P78362
LWDHNQHRKIIGYKP

ZNF585B

101

Q52M93
WVHEKRVREYKGHKQ

NSD3

321

Q9BZ95
HKRKAHGYVPGDQAW

ZNF142

591

P52746
QHERNHIAGYWKQVG

WLS

326

Q5T9L3