Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsemaphorin receptor activity

PLXNB2 PLXNA2 PLXNB1 PLXNB3 NRP2

9.04e-1012845GO:0017154
GeneOntologyBiologicalProcesssemaphorin-plexin signaling pathway

PLXNB2 PLXNA2 PLXNB1 PLXNB3 NRP2

2.09e-0652835GO:0071526
GeneOntologyBiologicalProcessregulation of signaling receptor activity

ACE2 DLGAP2 CBLB SHISA7 SHANK3 CNIH3

1.48e-05131836GO:0010469
GeneOntologyCellularComponentsemaphorin receptor complex

PLXNB2 PLXNA2 PLXNB1 PLXNB3 NRP2

1.24e-0913855GO:0002116
GeneOntologyCellularComponentglutamatergic synapse

DLGAP2 KCNA2 TSPOAP1 LAMA5 PLG CBLB SHISA7 SHANK3 PPM1H CNIH3 STAT3 NRP2

1.12e-048178512GO:0098978
GeneOntologyCellularComponentreceptor complex

VIPR1 IL31RA CR1 PLXNB2 SHISA7 PLXNA2 PLXNB1 PLXNB3 CNIH3 NRP2

1.23e-045818510GO:0043235
GeneOntologyCellularComponentneuronal cell body membrane

KCNA2 CD22 KCNB2

7.12e-0443853GO:0032809
GeneOntologyCellularComponentcell body membrane

KCNA2 CD22 KCNB2

9.25e-0447853GO:0044298
GeneOntologyCellularComponentexternal side of plasma membrane

THBS1 IL31RA CD22 CD27 MUC16 PLG CR1 RS1

1.23e-03519858GO:0009897
GeneOntologyCellularComponentextracellular matrix

THBS1 HMCN1 AHSG LAMA5 KAZALD1 PLG TECTA PLXNB2 PLXNA2

1.38e-03656859GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

THBS1 HMCN1 AHSG LAMA5 KAZALD1 PLG TECTA PLXNB2 PLXNA2

1.41e-03658859GO:0030312
GeneOntologyCellularComponentcollagen-containing extracellular matrix

THBS1 HMCN1 AHSG LAMA5 KAZALD1 PLG PLXNB2 PLXNA2

1.41e-03530858GO:0062023
GeneOntologyCellularComponentcell surface

ACE2 THBS1 IL31RA CD22 CD27 TREM2 MUC16 PLG CR1 PLXNB2 RS1 PLXNB3

1.74e-0311118512GO:0009986
DomainPlexin_cytopl

PLXNB2 PLXNA2 PLXNB1 PLXNB3

4.95e-089854PF08337
DomainPlexin_cytoplasmic_RasGAP_dom

PLXNB2 PLXNA2 PLXNB1 PLXNB3

4.95e-089854IPR013548
DomainPlexin

PLXNB2 PLXNA2 PLXNB1 PLXNB3

4.95e-089854IPR031148
DomainIPT

NFATC4 PLXNB2 PLXNA2 PLXNB1 PLXNB3

1.29e-0727855SM00429
DomainTIG

NFATC4 PLXNB2 PLXNA2 PLXNB1 PLXNB3

2.68e-0731855PF01833
DomainIPT

NFATC4 PLXNB2 PLXNA2 PLXNB1 PLXNB3

3.17e-0732855IPR002909
DomainSema

PLXNB2 PLXNA2 PLXNB1 PLXNB3

1.14e-0531854SM00630
DomainSemap_dom

PLXNB2 PLXNA2 PLXNB1 PLXNB3

1.14e-0531854IPR001627
DomainSema

PLXNB2 PLXNA2 PLXNB1 PLXNB3

1.14e-0531854PF01403
DomainSEMA

PLXNB2 PLXNA2 PLXNB1 PLXNB3

1.14e-0531854PS51004
DomainPSI

PLXNB2 PLXNA2 PLXNB1 PLXNB3

1.30e-0532854PF01437
DomainPlexin_repeat

PLXNB2 PLXNA2 PLXNB1 PLXNB3

1.30e-0532854IPR002165
Domain-

NBEAL2 TEP1 PLXNB2 PHIP PLXNA2 PLXNB1 PLXNB3 ARHGEF10L WDR24

2.05e-053338592.130.10.10
DomainARHGEF5_35

ARHGEF35 ARHGEF5

2.05e-052852PF15441
DomainARHGEF5/35_N

ARHGEF35 ARHGEF5

2.05e-052852IPR029212
DomainWD40/YVTN_repeat-like_dom

NBEAL2 TEP1 PLXNB2 PHIP PLXNA2 PLXNB1 PLXNB3 ARHGEF10L WDR24

2.15e-05335859IPR015943
DomainPSI

PLXNB2 PLXNA2 PLXNB1 PLXNB3

4.72e-0544854IPR016201
DomainPSI

PLXNB2 PLXNA2 PLXNB1 PLXNB3

5.64e-0546854SM00423
DomainIg_E-set

NFATC4 PLXNB2 PLXNA2 PLXNB1 PLXNB3

1.12e-04104855IPR014756
Domain-

IL31RA HMCN1 CD22 NFATC4 TSPOAP1 TREM2 KAZALD1 PLXNB2 PLXNA2 PLXNB1 PLXNB3

2.04e-0466385112.60.40.10
DomainNuc_rcpt_coact

NCOA2 CREBBP

3.03e-046852IPR009110
DomainIg-like_fold

IL31RA HMCN1 CD22 NFATC4 TSPOAP1 TREM2 KAZALD1 PLXNB2 PLXNA2 PLXNB1 PLXNB3

3.49e-047068511IPR013783
DomainConA-like_dom

THBS1 NBEAL2 SLIT1 LAMA5 SPSB2 NRP2

4.91e-04219856IPR013320
DomainRho_GTPase_activation_prot

PLXNB2 PLXNA2 PLXNB1 PLXNB3

6.97e-0488854IPR008936
DomainEGF

THBS1 HMCN1 SCARF2 SLIT1 LAMA5 TECTA

7.11e-04235856SM00181
DomainGrowth_fac_rcpt_

HMCN1 SCARF2 SLIT1 LAMA5 KAZALD1

7.31e-04156855IPR009030
DomainEGF-like_dom

THBS1 HMCN1 SCARF2 SLIT1 LAMA5 TECTA

9.60e-04249856IPR000742
DomainBTB

KCNA2 KLHL23 ZBTB41 KCNB2 KCTD17

1.38e-03180855SM00225
DomainBTB/POZ_dom

KCNA2 KLHL23 ZBTB41 KCNB2 KCTD17

1.56e-03185855IPR000210
DomainSushi

HP CR1 CSMD3

1.71e-0352853PF00084
DomainSKP1/BTB/POZ

KCNA2 KLHL23 ZBTB41 KCNB2 KCTD17

1.72e-03189855IPR011333
DomainBTB_2

KCNA2 KCNB2 KCTD17

1.81e-0353853PF02214
DomainT1-type_BTB

KCNA2 KCNB2 KCTD17

1.81e-0353853IPR003131
DomainCCP

HP CR1 CSMD3

1.91e-0354853SM00032
DomainSUSHI

HP CR1 CSMD3

2.12e-0356853PS50923
DomainSushi_SCR_CCP_dom

HP CR1 CSMD3

2.23e-0357853IPR000436
DomainLaminin_G

THBS1 SLIT1 LAMA5

2.34e-0358853IPR001791
DomainRasGAP_dom

PLXNB2 PLXNB1

2.99e-0318852IPR001936
DomainFA58C

RS1 NRP2

4.06e-0321852SM00231
DomainFA58C_3

RS1 NRP2

4.06e-0321852PS50022
DomainFA58C_1

RS1 NRP2

4.06e-0321852PS01285
DomainFA58C_2

RS1 NRP2

4.06e-0321852PS01286
DomainF5_F8_type_C

RS1 NRP2

5.29e-0324852PF00754
DomainFA58C

RS1 NRP2

5.29e-0324852IPR000421
DomainPAS

NCOA2 SIM2

5.74e-0325852PF00989
DomainPAS_fold

NCOA2 SIM2

5.74e-0325852IPR013767
DomainEGF_1

THBS1 HMCN1 SCARF2 SLIT1 LAMA5

6.17e-03255855PS00022
DomainPAC

NCOA2 SIM2

6.20e-0326852IPR001610
DomainBromodomain_CS

CREBBP PHIP

6.20e-0326852IPR018359
DomainPAC

NCOA2 SIM2

6.20e-0326852SM00086
DomainK_chnl_volt-dep_Kv

KCNA2 KCNB2

6.67e-0327852IPR003968
DomainEGF-like_CS

THBS1 HMCN1 SCARF2 SLIT1 LAMA5

6.79e-03261855IPR013032
DomainSH3_2

TSPOAP1 ARHGEF5 SHANK3

7.10e-0386853IPR011511
DomainSH3_2

TSPOAP1 ARHGEF5 SHANK3

7.10e-0386853PF07653
DomainEGF_2

THBS1 HMCN1 SCARF2 SLIT1 LAMA5

7.23e-03265855PS01186
DomainGalactose-bd-like

LAMA5 RS1 NRP2

9.05e-0394853IPR008979
PathwayKEGG_AXON_GUIDANCE

NFATC4 SLIT1 PLXNB2 PLXNA2 PLXNB1 PLXNB3

3.03e-05129666M5539
PathwayREACTOME_OTHER_SEMAPHORIN_INTERACTIONS

TREM2 PLXNA2 PLXNB3

9.00e-0519663M10959
PathwayREACTOME_SEMAPHORIN_INTERACTIONS

TREM2 PLXNA2 PLXNB1 PLXNB3

9.28e-0551664MM14967
PathwayWP_TGFBETA_SIGNALING_PATHWAY

THBS1 CREBBP STAT3 SMAD6

1.08e-0453664MM15880
PathwayWP_TGFBETA_RECEPTOR_SIGNALING

THBS1 CREBBP STAT3 SMAD6

1.25e-0455664M39351
PathwayWP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS

THBS1 CREBBP STAT3 SMAD6

1.64e-0459664M39886
PathwayREACTOME_SEMAPHORIN_INTERACTIONS

TREM2 PLXNA2 PLXNB1 PLXNB3

2.25e-0464664M7923
Pubmed

Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.

PLXNB2 PLXNA2 PLXNB1 PLXNB3 NRP2

6.81e-111287521270798
Pubmed

Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.

PLXNB2 PLXNA2 PLXNB1 PLXNB3 NRP2

1.10e-101387510520995
Pubmed

Semaphorin signaling facilitates cleft formation in the developing salivary gland.

PLXNB2 PLXNA2 PLXNB1 PLXNB3 NRP2

5.27e-101787517626059
Pubmed

The expression of plexins during mouse embryogenesis.

PLXNB2 PLXNA2 PLXNB1 PLXNB3

2.54e-09887415661641
Pubmed

Plexin-B family members demonstrate non-redundant expression patterns in the developing mouse nervous system: an anatomical basis for morphogenetic effects of Sema4D during development.

PLXNB2 PLXNB1 PLXNB3

6.04e-08487315147296
Pubmed

Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.

PLXNB2 PLXNA2 PLXNB1 PLXNB3

8.48e-081787411683995
Pubmed

TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6.

SLIT1 PLXNB2 PLXNA2 PLXNB1 NRP2

1.23e-074787535462405
Pubmed

Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF.

PLXNB2 PLXNB1 PLXNB3

1.51e-07587312183458
Pubmed

Interplay between scatter factor receptors and B plexins controls invasive growth.

PLXNB2 PLXNB1 PLXNB3

1.51e-07587315184888
Pubmed

An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.

PLXNB2 PLXNA2 PLXNB1 PLXNB3 NRP2

2.07e-075287526633812
Pubmed

A radial axis defined by semaphorin-to-neuropilin signaling controls pancreatic islet morphogenesis.

PLXNB2 PLXNA2 PLXNB1 NRP2

3.74e-072487428893946
Pubmed

Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.

SLIT1 PLXNA2 PLXNB1 NRP2

7.14e-072887418617019
Pubmed

The role of neuropilins in cell signalling.

PLXNA2 PLXNB1 NRP2

1.26e-06987319909241
Pubmed

A balance of noncanonical Semaphorin signaling from the cerebrospinal fluid regulates apical cell dynamics during corticogenesis.

PLXNB2 PLXNB1 NRP2

3.27e-061287336399562
Pubmed

Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology.

PLXNB2 PLXNB1 PLXNB3

3.27e-061287312123608
Pubmed

A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system.

PLXNB2 PLXNB1 PLXNB3

3.27e-061287320478304
Pubmed

An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration.

PLXNB2 PLXNB1 PLXNB3

4.25e-061387324572910
Pubmed

Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.

THBS1 HP AHSG PLG

4.59e-064487431273033
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

THBS1 HMCN1 LAMA5 PLG PLXNB2 PLXNA2

5.37e-0617587628071719
Pubmed

The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation.

PLXNB2 PLXNB1 NRP2

5.39e-061487322955271
Pubmed

MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion.

MUC16 NRP2

6.19e-06287235533267
Pubmed

Postlactational involution biomarkers plasminogen and phospho-STAT3 are linked with active age-related lobular involution.

PLG STAT3

6.19e-06287228752190
Pubmed

Functional regulation of semaphorin receptors by proprotein convertases.

PLXNB2 PLXNB1

6.19e-06287212533544
Pubmed

NEK6 is an injury-responsive kinase cooperating with STAT3 in regulation of reactive astrogliosis.

NEK6 STAT3

6.19e-06287234643969
Pubmed

Intermittent hypoxia mediated by TSP1 dependent on STAT3 induces cardiac fibroblast activation and cardiac fibrosis.

THBS1 STAT3

6.19e-06287231934850
Pubmed

Requirement of two NFATc4 transactivation domains for CBP potentiation.

NFATC4 CREBBP

6.19e-06287211514544
Pubmed

STAT3 isoforms differentially affect ACE2 expression: A potential target for COVID-19 therapy.

ACE2 STAT3

6.19e-06287232949179
Pubmed

Thrombospondin interaction with plasminogen. Evidence for binding to a specific region of the kringle structure of plasminogen.

THBS1 PLG

6.19e-0628722522013
Pubmed

ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4.

ATM NCOA4

6.19e-06287236752571
Pubmed

Ablation of Cbl-b provides protection against transplanted and spontaneous tumors.

ATM CBLB

6.19e-06287217364027
Pubmed

Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development.

PLXNB2 PLXNB1 PLXNB3

6.73e-061587321122816
Pubmed

PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.

PLXNB2 PLXNA2 PLXNB1 PLXNB3 NRP2

1.17e-0511787517145500
Pubmed

The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression.

CD27 CR1 CBLB SMAD6 NRP2

1.27e-0511987524162774
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

JCAD DLGAP2 NFATC4 TSPOAP1 ARHGEF5 ATM PRDM4 TMEM139

1.27e-0543087835044719
Pubmed

T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.

NCOA2 NCOA4 CREBBP

1.67e-052087311877444
Pubmed

Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.

HP NBEAL2 PLXNA2 PLXNB1

1.82e-056287419367581
Pubmed

Reduced expression of semaphorin 4D and plexin-B in breast cancer is associated with poorer prognosis and the potential linkage with oestrogen receptor.

PLXNB2 PLXNB1

1.85e-05387226035216
Pubmed

Hypoxia-inducible factor-1alpha enhances haptoglobin gene expression by improving binding of STAT3 to the promoter.

HP STAT3

1.85e-05387221224490
Pubmed

Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation.

CREBBP STAT3

1.85e-05387215649887
Pubmed

CD100 and plexins B2 and B1 mediate monocyte-endothelial cell adhesion and might take part in atherogenesis.

PLXNB2 PLXNB1

1.85e-05387226275342
Pubmed

Functional interaction of STAT3 transcription factor with the cell cycle inhibitor p21WAF1/CIP1/SDI1.

CREBBP STAT3

1.85e-05387210764767
Pubmed

The comparison of endogenous angiogenesis inhibitors in normotensive and preeclamptic placentas: an immunohistochemical study.

THBS1 PLG

1.85e-05387224205998
Pubmed

STAT3 and PD-L1 are negatively correlated with ATM and have impact on the prognosis of triple-negative breast cancer patients with low ATM expression.

ATM STAT3

1.85e-05387236056297
Pubmed

Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator.

THBS1 PLG

1.85e-0538726438154
Pubmed

Singleminded-2s (Sim2s) promotes delayed involution of the mouse mammary gland through suppression of Stat3 and NFκB.

SIM2 STAT3

1.85e-05387221292822
Pubmed

Sema4D stimulates axonal outgrowth of embryonic DRG sensory neurones.

PLXNB2 PLXNB1

1.85e-05387215330859
Pubmed

Stat3 inhibits WTX expression through up-regulation of microRNA-370 in Wilms tumor.

AMER1 STAT3

1.85e-05387223333300
Pubmed

ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition.

ATM SIM2

1.85e-05387230531838
Pubmed

Thrombospondin-1 induced programmed death-ligand 1-mediated immunosuppression by activating the STAT3 pathway in osteosarcoma.

THBS1 STAT3

1.85e-05387234927311
Pubmed

Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin.

PLXNB2 PLXNB3

1.85e-05387216122393
Pubmed

Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress.

ATM CREBBP

1.85e-05387215073328
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

NBEAL2 AOC2 LAMA5 TRMT11 PFAS KAZALD1 ZFPM1 TEP1 PLXNB2 AHDC1 ARHGEF10L WDR24

1.97e-051105871235748872
Pubmed

A mouse knockout library for secreted and transmembrane proteins.

ACE2 IL31RA NBEAL2 IL17C MUC16 KAZALD1 PLXNA2 TMEM139

2.07e-0546087820562862
Pubmed

Metabolic regulation of homologous recombination repair by MRE11 lactylation.

ATM CREBBP

3.70e-05487238128537
Pubmed

EID3 is a novel EID family member and an inhibitor of CBP-dependent co-activation.

NCOA2 CREBBP

3.70e-05487215987788
Pubmed

MOZ-TIF2 alters cofactor recruitment and histone modification at the RARbeta2 promoter: differential effects of MOZ fusion proteins on CBP- and MOZ-dependent activators.

NCOA2 CREBBP

3.70e-05487216613851
Pubmed

Haptoglobin interacts with the human mast cell line HMC-1 and inhibits its spontaneous proliferation.

CD22 HP

3.70e-05487211967116
Pubmed

A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies.

NCOA2 CREBBP

3.70e-05487211583620
Pubmed

Characterization of the antiplasmin activity of human thrombospondin-1 in solution.

THBS1 PLG

3.70e-0548727679575
Pubmed

Structural basis of semaphorin-plexin signalling.

PLXNA2 PLXNB1

3.70e-05487220877282
Pubmed

Grb2 mediates semaphorin-4D-dependent RhoA inactivation.

PLXNB2 PLXNB1

3.70e-05487222505611
Pubmed

MOZ-TIF2 repression of nuclear receptor-mediated transcription requires multiple domains in MOZ and in the CID domain of TIF2.

NCOA2 CREBBP

3.70e-05487217697320
Pubmed

Class 4 Semaphorins and Plexin-B receptors regulate GABAergic and glutamatergic synapse development in the mammalian hippocampus.

PLXNB2 PLXNB1

3.70e-05487229981480
Pubmed

The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor.

NCOA2 NCOA4

3.70e-05487215563469
Pubmed

A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.

PLXNA2 PLXNB1

3.70e-0548728570614
Pubmed

Genetic association of a polymorphism of the cAMP-responsive element binding protein-binding protein with steroid-induced osteonecrosis after kidney transplantation.

NCOA2 CREBBP

3.70e-05487217704997
Pubmed

Nuclear Smad6 promotes gliomagenesis by negatively regulating PIAS3-mediated STAT3 inhibition.

STAT3 SMAD6

3.70e-05487229950561
Pubmed

Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation.

CREBBP STAT3

3.70e-05487216651533
Pubmed

Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube.

SLIT1 PLXNA2 NRP2

4.23e-052787325843547
Pubmed

Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development.

PLXNB2 PLXNA2 NRP2

5.85e-053087332562661
Pubmed

Guidance-cue control of horizontal cell morphology, lamination, and synapse formation in the mammalian outer retina.

PLXNA2 NRP2

6.16e-05587222593055
Pubmed

Stat protein transactivation domains recruit p300/CBP through widely divergent sequences.

CREBBP STAT3

6.16e-05587210464260
Pubmed

Cell-based receptor discovery identifies host factors specifically targeted by the SARS CoV-2 spike.

ACE2 NRP2

6.16e-05587235931765
Pubmed

Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins.

PLXNB2 PLXNB1

6.16e-05587229040270
Pubmed

MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function.

NCOA2 CREBBP

6.16e-05587215657427
Pubmed

p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor.

NCOA2 CREBBP

6.16e-05587212810069
Pubmed

Mechanisms of TGF-beta1-induced intimal growth: plasminogen-independent activities of plasminogen activator inhibitor-1 and heterogeneous origin of intimal cells.

THBS1 PLG

6.16e-05587217431190
Pubmed

CBP Is a dosage-dependent regulator of nuclear factor-kappaB suppression by the estrogen receptor.

NCOA2 CREBBP

6.16e-05587217932106
Pubmed

Estrogen receptor-alpha interaction with the CREB binding protein coactivator is regulated by the cellular environment.

NCOA2 CREBBP

6.16e-05587214766010
Pubmed

K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse.

KCNA2 KCNB2

6.16e-0558722333511
Pubmed

Plexin-B3 is a functional receptor for semaphorin 5A.

PLXNB1 PLXNB3

6.16e-05587215218527
Pubmed

DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM.

ATM CREBBP

6.16e-05587216293623
Pubmed

Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms.

CREBBP STAT3

6.16e-05587211239394
Pubmed

Angiotensinogen gene expression is dependent on signal transducer and activator of transcription 3-mediated p300/cAMP response element binding protein-binding protein coactivator recruitment and histone acetyltransferase activity.

CREBBP STAT3

6.16e-05587211923478
Pubmed

A functional role for semaphorin 4D/plexin B1 interactions in epithelial branching morphogenesis during organogenesis.

PLXNB2 PLXNB1

6.16e-05587218799546
Pubmed

Analysis of acute-phase proteins, AHSG, C3, CLI, HP and SAA, reveals distinctive expression patterns associated with breast, colorectal and lung cancer.

HP AHSG

6.16e-05587221953030
Pubmed

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

THBS1 HMCN1 LAMA5 PLG PLXNB2

6.46e-0516787522159717
Pubmed

BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.

RBM22 SLIT1 TRMT11 QTRT2 CBLB PHIP STAT3

8.94e-0541987733001583
Pubmed

Characterization of the signaling capacities of the novel gp130-like cytokine receptor.

IL31RA STAT3

9.22e-05687215194700
Pubmed

The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways.

NCOA2 CREBBP

9.22e-0568729430642
Pubmed

Coregulated ataxia telangiectasia-mutated and casein kinase sites modulate cAMP-response element-binding protein-coactivator interactions in response to DNA damage.

ATM CREBBP

9.22e-05687217209043
Pubmed

Cross-talk between calcineurin/NFAT and Jak/STAT signalling induces cardioprotective alphaB-crystallin gene expression in response to hypertrophic stimuli.

NFATC4 STAT3

9.22e-05687219538478
Pubmed

Regulation of T cell activation by HIV-1 accessory proteins: Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB.

NFATC4 CREBBP

9.22e-05687212788643
Pubmed

Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination.

NCOA2 CREBBP

9.22e-05687215731352
Pubmed

Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages.

PLXNA2 NRP2

9.22e-05687219480842
Pubmed

Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema.

LAMA5 NRP2

9.22e-05687235235341
Pubmed

Stat3 dimerization regulated by reversible acetylation of a single lysine residue.

CREBBP STAT3

9.22e-05687215653507
Pubmed

Trp53 deficiency protects against acute intestinal inflammation.

ATM STAT3

1.29e-04787223772033
Pubmed

Ataxia telangiectasia mutated proteins, MAPKs, and RSK2 are involved in the phosphorylation of STAT3.

ATM STAT3

1.29e-04787212562765
Pubmed

BRCA1-IRIS regulates cyclin D1 expression in breast cancer cells.

NCOA2 CREBBP

1.29e-04787216860316
Cytoband2p13.2

FBXO41 SMYD5

2.31e-04128722p13.2
GeneFamilyPlexins

PLXNB2 PLXNA2 PLXNB1 PLXNB3

1.03e-089564683
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

HP CR1 CSMD3

7.31e-04575631179
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ARHGEF35 ARHGEF5 ARHGEF10L

1.12e-0366563722
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

NCOA2 CREBBP

1.24e-0317562486
ToppCellCOVID-19-Endothelial_cells-Capillary_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

JCAD VIPR1 LAMA5 ITPRID1 SHANK3 PLXNA2 SMAD6

6.76e-08181877c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NBEAL2 CHD1L TEP1 ANKRD52 SPSB2 WDR24

1.50e-06181876f6629fa71bb94405f523f63a9264cacf6d15c5f4
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

JCAD SHROOM1 HMCN1 SHANK3 PLXNA2 SMAD6

1.71e-06185876a7ae76058b2082020cadec49d63b9f4e24d21734
ToppCellLV-10._Endothelium_II|World / Chamber and Cluster_Paper

HMCN1 TECTA SHANK3 PLXNA2 PPM1H SMAD6

1.82e-061878767876dcb4800c2e54874df3d933efb79307a64a97
ToppCellCOVID-19-Endothelial_cells-Inflamed_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

JCAD VIPR1 LAMA5 SHANK3 PLXNA2 SMAD6

2.18e-06193876979ebefa527f86bebeea5d94e626ee6c1cc7d53b
ToppCellMS-CD8-CD8_2|MS / Condition, Cell_class and T cell subcluster

ISYNA1 CD27 ATM SIM2 CBLB

1.14e-0515087501c20d787ce269db0d153e63a600a8d9ead61856
ToppCellfacs-Lung-Endomucin-3m-Myeloid-Classical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 HP TREM2 TEP1 PPM1H

1.30e-0515487527f76e4b3c055aa382708f1610c685f02d6d6114
ToppCellfacs-Lung-Endomucin-3m-Myeloid-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 HP TREM2 TEP1 PPM1H

1.30e-051548758746663a822d93a8510081c81a8c971b51653067
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma|TCGA-Bladder / Sample_Type by Project: Shred V9

ZFPM1 PLXNB1 PLXNB3 ARHGEF10L SMAD6

1.47e-05158875dc559503bab3ec1b9ea54ef2e896d1be33e5344c
ToppCellfacs-Marrow-Granulocytes-24m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCARF2 AOC2 TREM2 LAMA5 NRP2

1.66e-051628752787be283b7a705647058aeb9bc54006ce5ffe95
ToppCelldroplet-Spleen-nan-18m-Hematologic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 HP TREM2 PLXNB2 ARHGEF10L

1.86e-05166875e841e62cb20235d6233f78f4155fb8c0ffb1ef1b
ToppCelldroplet-Spleen-nan-18m-Hematologic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 HP TREM2 PLXNB2 ARHGEF10L

1.86e-051668753ca3ddb663644f0e7f70f9b75833bb54cd9191d3
ToppCelldroplet-Spleen-nan-18m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMCN1 HP TREM2 PLXNB2 ARHGEF10L

1.86e-05166875f751cbd01d4978ded7755874ab60504f6291afd7
ToppCellfacs-Marrow-Granulocytes-24m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AOC2 TREM2 LAMA5 PLXNB2 NRP2

2.09e-051708758d3c51364a332020810836e2055c60893c10d7f3
ToppCelldroplet-Fat-Scat-18m|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 HP TREM2 PLXNB2 ARHGEF10L

2.21e-051728758a4a5ad65eec92ce4fa45c5aa01c28666307455b
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

JCAD VIPR1 SHROOM1 SHANK3 SMAD6

2.21e-05172875de9b11ab109d04937186c09772cec9105a935f95
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HP TREM2 TEP1 PLXNB2 ARHGEF10L

2.27e-05173875807183fc23478da9451906dacd88de4e73112e0d
ToppCellfacs-Marrow-Granulocytes-18m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HP TREM2 TEP1 PLXNB2 ARHGEF10L

2.27e-051738752e683ec555dc0036875e0f5674dcc5e93ead205d
ToppCelldroplet-Lung-18m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l14|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

THBS1 HP TREM2 PPP1R3G TEP1

2.34e-0517487502ab165b064acb91f2d3f59cc5be195899d61a83
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_activate-7|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SHROOM1 PRSS53 CD22 ARHGEF5 ZFPM1

2.47e-05176875dde46f06f6fc3f7ba83be91a0ee6231790955e3e
ToppCellBAL-Mild-cDC_4|Mild / Compartment, Disease Groups and Clusters

NEK6 FBXO41 TRMT11 MUC16 SMYD5

2.67e-0517987568511e87b12b8253de7771e5ccfc5869248b8450
ToppCellControl-Endothelial_cells-Capillary_endothelial_cells|Control / group, cell type (main and fine annotations)

JCAD VIPR1 ITPRID1 SHANK3 SMAD6

2.75e-05180875b043f9ffb9a4cd427a15bebb86a711c7b08866e8
ToppCelldroplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JCAD HMCN1 SHANK3 CNIH3 NRP2

2.82e-051818754df7972f88117108698efd06b124b232f8588981
ToppCelldroplet-Liver-hepatocytes-3m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JCAD HMCN1 SHANK3 CNIH3 NRP2

2.82e-05181875cbb530566893281289026bfd93adf721decd4ca3
ToppCelldroplet-Tongue-nan-24m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE2 PRSS53 KAZALD1 PLXNA2 NRP2

3.21e-051868752913b5fd0617d024d600ba7015ec7b1961dade83
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

NCOA2 AMER1 HMCN1 NCOA4 CREBBP

3.21e-0518687503db813598b67b1e08f759758a1c2023396921fa
ToppCellpdx-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

JCAD DLGAP2 LAMA5 PPM1H NRP2

3.30e-051878757e376831a11ee72ed87abcdac631ca46ae29c250
ToppCellControl-Endothelial-VE_Capillary_A|Control / Disease state, Lineage and Cell class

JCAD VIPR1 LAMA5 SHANK3 SMAD6

3.30e-0518787554d7588172ac145ff5045ad9771636729ca3f0ca
ToppCellControl-Endothelial_cells-Arterial_endothelial_cells|Control / group, cell type (main and fine annotations)

JCAD VIPR1 SHANK3 PLXNA2 SMAD6

3.30e-0518787581affaab3fe3e1daea45ada6445e906ddd33950e
ToppCellAdult-Endothelial-capillary_endothelial_cell_(Cap1)-D122|Adult / Lineage, Cell type, age group and donor

JCAD VIPR1 SHANK3 PLXNA2 SMAD6

3.38e-0518887502a62888e9db29d20133eeca1686d302545a39c9
ToppCellRA-10._Endothelium_II|RA / Chamber and Cluster_Paper

HMCN1 SHANK3 PLXNA2 PPM1H SMAD6

3.47e-05189875c81787a8c662db5d7814c583dd64562857629e81
ToppCelldroplet-Tongue-nan-24m-Epithelial-filiform|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRSS53 SCARF2 TESK2 KAZALD1 PLXNA2

3.56e-0519087586ab845a7fae2111c0b01e1aec235e19c4c0ef5c
ToppCelldroplet-Tongue-nan-3m-Epithelial-filiform|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRSS53 SCARF2 TESK2 KAZALD1 PLXNA2

3.56e-05190875251e3a33041023bfc4b547c7eb68cfb8f421636f
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

JCAD VIPR1 LAMA5 SHANK3 SMAD6

3.56e-051908750a351609a72fd638c84b2435782e312ee6a33aac
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery|Children_(3_yrs) / Lineage, Cell type, age group and donor

JCAD SHROOM1 HMCN1 SHANK3 SMAD6

3.56e-05190875f6c38d197fd9d69a4f97cb2e72cd4747984c1a86
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-filiform|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRSS53 SCARF2 TESK2 KAZALD1 PLXNA2

3.56e-051908758a53f4d3c9aca45b5826f53f7dcdfb8bc8280acb
ToppCellRV-10._Endothelium_II|World / Chamber and Cluster_Paper

HMCN1 SHANK3 PLXNA2 PPM1H SMAD6

3.83e-051938752531266bc57339d4e2b22a88817008e32b8c1598
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-suprabasal|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE2 PRSS53 KAZALD1 PLXNA2 NRP2

3.93e-05194875a3adcdc8b87332e8beb9bcd70cf36424af10633d
ToppCelldroplet-Liver-LIVER-NPC-1m-Mesenchymal-hepatic_stellate_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE2 VIPR1 NFATC4 SCARF2 KLHL23

3.93e-05194875415801a3dfacf05f2b603fb424df3d045190a812
ToppCellLV-10._Endothelium_II|LV / Chamber and Cluster_Paper

HMCN1 TECTA SHANK3 PLXNA2 SMAD6

3.93e-05194875b6cc849fa08599bff9839ef382d190cc964e273e
ToppCelldroplet-Liver-LIVER-NPC-1m-Mesenchymal-hepatic_stellate_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE2 VIPR1 NFATC4 SCARF2 KLHL23

3.93e-05194875256cb33ec90328f2704921fb0fe0fd9812e138b0
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

JCAD VIPR1 LAMA5 SHANK3 SMAD6

3.93e-0519487568004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCelldroplet-Liver-LIVER-NPC-1m-Mesenchymal|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACE2 VIPR1 NFATC4 SCARF2 KLHL23

3.93e-051948757942bc83c1bdca687795b91aa232824d603f9b09
ToppCellBronchial_Biopsy-Immune-Luminal_Macrophages|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

HP SCARF2 TREM2 CR1 NRP2

4.02e-051958756800c17026ec6c56132bf4664b8fcd74d7836579
ToppCellChildren_(3_yrs)-Endothelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

JCAD VIPR1 DLGAP2 SHANK3 SMAD6

4.02e-05195875094cf6591daa5ffad36e44122b6f524a3a34c2fd
ToppCellCOVID-19-lung-Capillary_Aerocytes|COVID-19 / Disease (COVID-19 only), tissue and cell type

JCAD VIPR1 LAMA5 SHANK3 SMAD6

4.12e-0519687549cc0a2b9739abad61dff7292ea0b14d28ff35c4
ToppCellCOVID-19-lung-Capillary_Aerocytes|lung / Disease (COVID-19 only), tissue and cell type

JCAD VIPR1 LAMA5 SHANK3 SMAD6

4.12e-051968754ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCell10x3'2.3-week_17-19-Endothelial-stroma-sinusoidal_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

JCAD HMCN1 SHANK3 SMAD6 NRP2

4.22e-051978754e58bbf3ecb30b4c8199adcc04d2eb134d90de56
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS_only / Treatment groups by lineage, cell group, cell type

ACE2 C16orf90 GALK2 PLXNB2 PLXNA2

4.22e-051978756b6504c47c309bac4f790e2f372d454bbdea49e8
ToppCellLV-09._Endothelium_I|LV / Chamber and Cluster_Paper

JCAD HMCN1 SHANK3 PLXNA2 SMAD6

4.22e-05197875f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

JCAD HMCN1 SHANK3 PLXNA2 PPM1H

4.33e-05198875e1fa02184ce93c4f8aa5cf04b70949cd4c425ff0
ToppCellCOVID-19-lung-Capillary_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

JCAD VIPR1 LAMA5 SHANK3 SMAD6

4.33e-0519887545419f2804b4be79bae6632e71c54e1af482d115
ToppCellCOVID-19-lung-Capillary_2|lung / Disease (COVID-19 only), tissue and cell type

JCAD VIPR1 LAMA5 SHANK3 SMAD6

4.43e-05199875793ce71b78a68033ef4419ed571e1dd86b40124f
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

JCAD VIPR1 ARHGEF35 HMCN1 SHANK3

4.43e-05199875d95d78b2ebc9a20532466e4d4be579b4faf6776f
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

JCAD VIPR1 ARHGEF35 HMCN1 SHANK3

4.43e-05199875cdcfca94baba66e213cc3ffb0cfb4c75d6ab44ec
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial|GW16 / Sample Type, Dataset, Time_group, and Cell type.

CD22 NFATC4 SCARF2 LRCH4 SLFN11

4.54e-0520087525f4c051c2e869481f33c22ad54de97efac444ad
ToppCelldistal-Endothelial-Capillary_Intermediate_1-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

JCAD VIPR1 LAMA5 SHANK3 SMAD6

4.54e-0520087543bc48413b100a06f8edd9acd812296788fcbf5b
ToppCell5'-Adult-SmallIntestine-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JCAD LAMA5 SHANK3 SMAD6 NRP2

4.54e-052008752554b77edfe3d378296b0b25625caacbfb1c0e76
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW16-Neuroepithelial-Proteoglycan-expressing_cell|GW16 / Sample Type, Dataset, Time_group, and Cell type.

CD22 NFATC4 SCARF2 LRCH4 SLFN11

4.54e-05200875da45a85a4667965b24ba824af871157af5b4cd19
ToppCelldistal-Endothelial-Capillary_Intermediate_1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

JCAD VIPR1 LAMA5 SHANK3 SMAD6

4.54e-052008754d6714d48738cdee7d535923f6dd2431e5304741
ToppCellfacs-Thymus-Epithelium-3m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TREM2 PPM1H ARHGEF10L WDR24

1.30e-041328746f711fe84135406a8114a898a14c5ea0dfad74f2
ToppCellNS-moderate-d_16-33-Epithelial-unknown_epithelial|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

LAMA5 MUC16 PLXNB2 PLXNB1

1.51e-0413787403e124901a0e85b59b6882bbafab568b50907e8b
ToppCell356C-Epithelial_cells-Epithelial-B_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NCOA2 DLGAP2 HP CD27

1.59e-04139874aefcfda2b2db302ce4b3d2a09f767be0b1c3ac6c
ToppCell356C-Epithelial_cells-Epithelial-B_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NCOA2 DLGAP2 HP CD27

1.59e-04139874b9c2dfab119ac0efdf931bb2910e82bccdb4e48d
ToppCellClub-club-1|World / Class top

HP PFAS SH2D4B

1.61e-045487348f80b20b1c4995a0f7084d31666781dce4009a9
ToppCell356C-Epithelial_cells-Epithelial-C_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

VIPR1 CD22 HP RPP25L

1.77e-04143874b74571d30def54a0524c8d95a3bc9d3439319eb4
ToppCell356C-Epithelial_cells-Epithelial-C_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

VIPR1 CD22 HP RPP25L

1.77e-041438745c81b238be53f010d691d0c59c1c29cb52222ed3
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD8-Trm/em_CD8|GI_small-bowel / Manually curated celltypes from each tissue

CD27 SLIT1 PPP1R3G MTUS2

1.82e-04144874a4bb274d553c29c8299354de757ecc5634008c68
ToppCellAT1-AT2_cells-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

ACE2 LRCH4 RS1 PLXNB1

1.87e-04145874cd5de30fd948024e3ad043c9411ce9f2722178b2
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NEK6 FBXO41 MUC16 SMYD5

2.08e-04149874a85a051e0d82430160967e72fa04b55f43e84513
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NEK6 FBXO41 MUC16 SMYD5

2.13e-041508747a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCellfacs-Marrow-T-cells-24m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TREM2 TEP1 PLXNB2 ARHGEF10L

2.24e-04152874d279592c501fca9cb474ad916fea32282e6969cb
ToppCellfacs-Marrow-T-cells-24m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TREM2 TEP1 PLXNB2 ARHGEF10L

2.24e-041528743b59143b2b4ee24eb6378f87ff568124193256e9
ToppCelldroplet-Liver-HEPATOCYTES-1m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VIPR1 KCNA2 KLHL23 TMEM139

2.54e-04157874b527e88382c8d21188a0f222b3302523e8816dfc
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

JCAD SHANK3 PLXNB3 SMAD6

2.66e-04159874d3f81ba22160568ccaa6d2b04ebfd30630f9a6db
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-Enterocyte_(Proximal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HP TESK2 KAZALD1 SMAD6

2.66e-04159874709b57f992a29878cc899d760d144d36cb5cb280
ToppCellControl-Endothelial_cells-Inflamed_endothelial_cells|Control / group, cell type (main and fine annotations)

JCAD VIPR1 SHANK3 SMAD6

2.73e-04160874958256e3d3836160763b82bb48f794087918d935
ToppCelldroplet-Liver-HEPATOCYTES-1m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VIPR1 KCNA2 KLHL23 TMEM139

2.73e-04160874a494001b1f6dec33624f98fa3c24bad6988d0425
ToppCellE15.5-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRCH4 KAZALD1 CHD1L SIM2

2.79e-041618749703b7e67d9fadb6129cad166bd01be915042e44
ToppCellPND07-28-samps-Epithelial-Epithelial-non_alveolar-Club_cell|PND07-28-samps / Age Group, Lineage, Cell class and subclass

HP ITPRID1 SPSB2 TMEM139

2.86e-04162874aed15eef32419b8a4e2afdb9776c2bf2802e96f1
ToppCellfacs-Marrow-T_cells-18m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TREM2 PLXNB2 PLXNB3 ARHGEF10L

2.92e-0416387430cd95d4f37bd54c1fde54960cb005db58bdd30c
ToppCellfacs-Marrow-T_cells-18m-Myeloid-monocyte_+_promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TREM2 PLXNB2 PLXNB3 ARHGEF10L

2.92e-04163874ab934cb986495adfc8dbe5a276577f2a8fb6ee03
ToppCell356C-Lymphocytic-NK_cells-NK_cell_E|356C / Donor, Lineage, Cell class and subclass (all cells)

CD27 TESK2 KLHL23 PFAS

2.99e-04164874d5bb57c321f2973836efc8990449494cc1fb87c7
ToppCelldroplet-Lung-21m-Hematologic-myeloid-intermediate_monocyte|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HP TREM2 PLXNB2 ARHGEF10L

2.99e-04164874cd0794f84dfd346807e2d803723718b7f22e9232
ToppCelldroplet-Lung-21m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l4|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HP TREM2 PLXNB2 ARHGEF10L

2.99e-0416487412251a49fd4af32d4edb58046245548c260cf04b
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C16orf90 SHROOM1 NBEAL2 LAMA5

2.99e-04164874fe11fcce4ba7f44ba2989ea3705916b67e75f8e7
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C16orf90 SHROOM1 NBEAL2 LAMA5

2.99e-04164874b6beb8548ac0dd07e8a580a938e5ee4bf25a3c1f
ToppCellfacs-Heart-LV-3m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 HP CSMD3 MTUS2

3.06e-0416587484eca6a0f5e996b6955ae79fa102af239098fe8f
ToppCellfacs-Heart-LV-3m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THBS1 HP CSMD3 MTUS2

3.06e-04165874af59a095ecc6758abc13d763c00e44447c488167
ToppCelldroplet-Mammary_Gland-nan-21m-Epithelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VIPR1 NBEAL2 ZBTB41 PLXNA2

3.06e-041658747c771f22b58989572c939ed127e637ec28dc0dca
ToppCell368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|368C / Donor, Lineage, Cell class and subclass (all cells)

JCAD VIPR1 LAMA5 SHANK3

3.13e-0416687430a991fc3275b571d53bd0976df4789e5d40b01d
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage_3|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

JCAD NFATC4 SCARF2 SHANK3

3.13e-04166874f416d8a322f086c769659a9fab6b460a2d546ab1
ToppCell368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|368C / Donor, Lineage, Cell class and subclass (all cells)

JCAD VIPR1 LAMA5 SHANK3

3.13e-0416687476b4cd32698900797ec009f17e50ea7ae36b85f4
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-mesothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SIM2 RS1 SHISA7 PLXNB3

3.21e-04167874743df5908c1ceb43b34b240d9f9649f30f4142fa
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D231|Adult / Lineage, Cell type, age group and donor

JCAD VIPR1 SHANK3 SMAD6

3.21e-041678745af9127bae05768a5164d5708a4ad37edca99324
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-mesothelial_cell-mesothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SIM2 RS1 SHISA7 PLXNB3

3.21e-041678741adb566f98af0109c8cc6e36033b89651e2c75e7
ToppCell3'_v3-bone_marrow-Myeloid_Mac-Intermediate_macrophages|bone_marrow / Manually curated celltypes from each tissue

NEK6 TREM2 SMAD6 NRP2

3.28e-041688748ade4d098aeecda2d80c1cad1cebe9a063eae948
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D122|Adult / Lineage, Cell type, age group and donor

JCAD HMCN1 SHANK3 SMAD6

3.28e-041688748c3e1e45b422813bcdfa4273b1167db649a312f5
ToppCelldroplet-Lung-18m-Hematologic-myeloid-intermediate_monocyte|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TREM2 TEP1 PLXNB2 ARHGEF10L

3.28e-0416887400cff4698db14e03ca1d1b409e5ed1ad23b12615
ToppCelldroplet-Spleen-SPLEEN-1m-Hematologic-proerythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HP TREM2 PLXNB2 ARHGEF10L

3.28e-04168874f3b7a7df54988de77dcc7066e2fc1feb9c280b13
Diseaseobesity (implicated_via_orthology)

HP PLXNB2 PLXNB1 PLXNB3 STAT3

3.39e-04215825DOID:9970 (implicated_via_orthology)
Diseaseresponse to paliperidone, schizophrenia symptom severity measurement

JCAD DLGAP2 HMCN1 CR1 CSMD3

3.46e-04216825EFO_0007925, EFO_0007927
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

PLXNB2 PLXNB1 PLXNB3

3.48e-0449823DOID:0060037 (implicated_via_orthology)
DiseaseFibrosis

THBS1 ATM STAT3

3.69e-0450823C0016059
DiseaseCirrhosis

THBS1 ATM STAT3

3.69e-0450823C1623038
Diseasenucleus accumbens volume change measurement

MUC16 ITPRID1

4.13e-0411822EFO_0021493
DiseaseSemantic-Pragmatic Disorder

KCNA2 SHANK3

4.13e-0411822C0454655
DiseaseAuditory Processing Disorder, Central

KCNA2 SHANK3

4.13e-0411822C0751257
DiseaseLanguage Delay

KCNA2 SHANK3

4.13e-0411822C0023012
DiseaseLanguage Development Disorders

KCNA2 SHANK3

4.13e-0411822C0023014
DiseaseSpeech Delay

KCNA2 SHANK3

4.13e-0411822C0241210
Diseaseleukemia

HP ATM STAT3

4.89e-0455823C0023418
DiseaseSchizophrenia

DLGAP2 THBS1 HP IL17C ATM PLG SHANK3 PLXNA2 CNIH3

7.69e-04883829C0036341
Diseasehepcidin:transferrin saturation ratio

MUC16 KCTD17

7.82e-0415822EFO_0007902
Diseaseobsolete aging, cognition

DLGAP2 CBLB

7.82e-0415822EFO_0003925, GO_0007568
DiseaseDiabetic Angiopathies

THBS1 HP

8.93e-0416822C0011875
DiseaseMicroangiopathy, Diabetic

THBS1 HP

8.93e-0416822C0025945
Diseaseheart disease (biomarker_via_orthology)

THBS1 STAT3

1.01e-0317822DOID:114 (biomarker_via_orthology)
Diseasepre-malignant neoplasm (biomarker_via_orthology)

ATM STAT3

1.01e-0317822DOID:0060071 (biomarker_via_orthology)
Diseaseleukemia (implicated_via_orthology)

MEIS3P2 ATM

1.27e-0319822DOID:1240 (implicated_via_orthology)
Diseaselate-onset Alzheimers disease

HMCN1 TREM2 ATM TECTA CR1

1.34e-03292825EFO_1001870
DiseaseMalaria

HP CR1

1.40e-0320822C0024530
Diseaseatherosclerosis (biomarker_via_orthology)

HP STAT3

1.40e-0320822DOID:1936 (biomarker_via_orthology)
DiseaseCOVID-19 (is_implicated_in)

ACE2 PLG

1.55e-0321822DOID:0080600 (is_implicated_in)
DiseaseObsessive-compulsive trait

TRMT11 PPM1H

1.55e-0321822HP_0008770
DiseaseDrug toxicity

HP AHSG PLG

1.68e-0384823C0013221
DiseaseAdverse reaction to drug

HP AHSG PLG

1.68e-0384823C0041755
Diseaseidiopathic pulmonary fibrosis (is_marker_for)

STAT3 SMAD6

1.86e-0323822DOID:0050156 (is_marker_for)
Diseasecolon adenocarcinoma (is_marker_for)

PFAS STAT3

2.20e-0325822DOID:234 (is_marker_for)
DiseaseLymphatic Metastasis

TRMT11 STAT3

2.37e-0326822C0024232
Diseasecolorectal health

DLGAP2 KCNB2 CBLB PPM1H

2.42e-03201824EFO_0008460
DiseaseAdenoid Cystic Carcinoma

ISYNA1 ATM CREBBP

2.76e-03100823C0010606

Protein segments in the cluster

PeptideGeneStartEntry
YDDVPCESPDAHQPG

ARHGEF10L

131

Q9HCE6
YNTFGHNECPDPGIP

CSMD3

826

Q7Z407
KGESPVEPAEPCHYS

CD27

221

P26842
IAPEDSPHCDLFPGA

ARHGEF5

411

Q12774
IAPEDSPHCDLFPGA

ARHGEF35

411

A5YM69
PSEGDDYIFHCHPPD

CREBBP

1476

Q92793
ENSPPGDDCLYDLHG

AMER1

516

Q5JTC6
ESPYGNLCDAPDSPR

AKAP11

421

Q9UKA4
PVAHCYPDALQSPFG

DLGAP2

321

Q9P1A6
CRDLPLGQPHYDSPS

AHDC1

1446

Q5TGY3
ALPHGASCPYSQERP

ANKRD52

1051

Q8NB46
VTDHPGKEEFCSPPY

MTUS2

736

Q5JR59
GEECPYRHEKPTDPD

RBM22

176

Q9NW64
HAIYLNGEECPPASP

TSPOAP1

911

O95153
SNPVLYTPGEEPDHC

ISYNA1

366

Q9NPH2
SPCPAEDLFPGHRYD

LRCH4

281

O75427
LAACVPDLPPFSYHG

AOC2

741

O75106
CTYHPDPVGPGLDIQ

MUC16

14146

Q8WXI7
EAAALPGHPQDTYDP

KCNA2

11

P16389
GPCESGPQIVSHPYD

KAZALD1

166

Q96I82
DGCPKPPEIAHGYVE

HP

31

P00738
PDHLCEEGAPNPYLK

IL31RA

696

Q8NI17
QSLQACDDLLPYPPH

ITPRID1

316

Q6ZRS4
HELCLSDPGLEPPVY

JCAD

326

Q9P266
SYNPDLTGLCEPTPH

CBLB

336

Q13191
YHHPPDDSALCAFPI

PLXNA2

346

O75051
TLDAYPCGSDHTPSP

PLXNB1

371

O43157
DELLCLFGESPPHPA

PLXNB2

551

O15031
PLDSPESYPCGDEHT

PLXNB3

361

Q9ULL4
ESYPCGDEHTPSPIA

PLXNB3

366

Q9ULL4
HPEPYNPEEICRCLG

GALK2

291

Q01415
PGAPAPALADYHECT

ZFPM1

806

Q8IX07
ESPGFPEKYPHNLDC

NRP2

161

O60462
IEQCDYPPLPGEHYS

NEK6

261

Q9HC98
CYSAEELPLGQAPPH

IL17C

36

Q9P0M4
GPTCSEPARDHYLPD

LAMA5

856

O15230
YKPEAPGCEAPDHLQ

KCTD17

301

Q8N5Z5
PPNDLECALSPYALE

HMCN1

5521

Q96RW7
DELPHYPSIADGPAA

MEIS3P2

6

A8K0S8
PPDHYGLPAVCDLFA

NCOA4

581

Q13772
LHDPVSPCPAGYVTN

QTRT2

96

Q9H974
CDFSGDLDPAPNPPH

ATM

1366

Q13315
SSPHPEYGLCSVPFE

KLHL23

451

Q8NBE8
APEIHSNPGDTGYCP

KCNB2

891

Q92953
PFGKAVNYTCDPHPD

CR1

891

P17927
HGPGLIYRQPNCDDP

AHSG

21

P02765
CVDHPYLFDGVEPEP

CHD1L

321

Q86WJ1
GVVEPVPHDETYCDP

ACE2

486

Q9BYF1
GLYLESHPPPTGQCE

C16orf90

66

A8MZG2
AHFPGDLVPASLPCE

FBXO41

116

Q8TF61
PPPDCDDTVTYSALH

CD22

786

P20273
DRAYPSDCPEHGPVT

PRDM4

381

Q9UKN5
PAASYVCTPEAHEPD

SKOR1

791

P84550
GLDPNCIPENPHNIY

TRMT11

156

Q7Z4G4
LQHAPEPDAADGPYD

SMAD6

446

O43541
PHEDPACETPYLSEG

NFATC4

726

Q14934
EAPCPDPDGFYHALS

NBEAL2

1336

Q6ZNJ1
PSFPSCGHYREEPAL

SIM2

541

Q14190
PTEYPLHECPGTAGA

SHROOM1

436

Q2M3G4
AAARAPPPAELCHGY

SHISA7

71

A6NL88
DCSGLPPLSDQYPRE

SLFN11

711

Q7Z7L1
HFSLCLPPGLQPEDE

PPP1R3G

301

B7ZBB8
DLDHPNLAEYTGCPP

CYB5D2

241

Q8WUJ1
APPELTPVVQDCYHG

PLG

366

P00747
FHCPADSSELAYDPP

CNIH3

106

Q8TBE1
FGSSPDDLLCPHPAA

NCOA2

1056

Q15596
CIEPPPYGNNSHDII

TECTA

1786

O75443
LCLPYPDHHLPDGER

PRSS53

401

Q2L4Q9
THLEPGPYPIACGLD

VIPR1

111

P32241
KIPDDRDNCPFHYNP

THBS1

746

P07996
SCPPEALGDLPYHLL

TEP1

1536

Q99973
AALHCGRPPESPVNY

PHIP

126

Q8WWQ0
PNFHDPDSGECPLSL

SHANK3

141

Q9BYB0
LPNCDPDDPHRYTLA

PPM1H

456

Q9ULR3
YCRPESQEHPEADPG

STAT3

686

P40763
GPVYCVPHEEAPAES

SCARF2

561

Q96GP6
CFSQLGEHPPDLDLP

PFAS

871

O15067
GRPTPEALHCYQELP

ZBTB41

41

Q5SVQ8
EALHCYQELPPSPDQ

ZBTB41

46

Q5SVQ8
PQALYPDLSCPEGLE

SPSB2

16

Q99619
LSRDPLDPNECGYQP

RPP25L

121

Q8N5L8
HPPSELDCGHDPGYQ

TREM2

206

Q9NZC2
PCGQRDSPPDYHLLF

SH2D4B

416

Q5SQS7
YLLDPEHAHPEDPEC

WDR24

551

Q96S15
PECPYHKPLGFESGE

RS1

61

O15537
SLPGSPEFLHQEACP

TESK2

456

Q96S53
EGYSGQLCEIPPHLP

SLIT1

1111

O75093
YHQVLCPGPSQDDPL

SMYD5

131

Q6GMV2
PPPAYDVCFGHPDDD

TMEM139

191

Q8IV31