Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

TRIM45 RNF213 TRIM50 HERC2 RNF168 CNOT4

3.32e-05473276GO:0004842
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

TRIM45 RNF213 TRIM50 HERC2 RNF168 CNOT4

5.16e-05512276GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

TRIM45 RNF213 TRIM50 HERC2 RNF168 CNOT4

6.39e-05532276GO:0016755
GeneOntologyMolecularFunctionubiquitin protein ligase activity

TRIM45 RNF213 TRIM50 HERC2 RNF168

1.26e-04372275GO:0061630
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

TRIM45 RNF213 TRIM50 HERC2 RNF168

1.72e-04398275GO:0061659
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH9 DNAH1

2.66e-0418272GO:0008569
GeneOntologyMolecularFunctionacyltransferase activity

TRIM45 RNF213 TRIM50 HERC2 RNF168 CNOT4

4.93e-04775276GO:0016746
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH9 DNAH1

6.51e-0428272GO:0051959
GeneOntologyMolecularFunctiontransition metal ion binding

TRIM45 ADAMTS20 TRIM50 THRB HERC2 AKAP8 EPAS1

8.07e-041189277GO:0046914
GeneOntologyMolecularFunctionzinc ion binding

TRIM45 ADAMTS20 TRIM50 THRB HERC2 AKAP8

1.03e-03891276GO:0008270
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH9 DNAH1

1.14e-0337272GO:0045505
GeneOntologyMolecularFunctiontranscription coactivator binding

THRB EPAS1

2.41e-0354272GO:0001223
GeneOntologyMolecularFunctionmicrotubule motor activity

DNAH9 DNAH1

4.02e-0370272GO:0003777
GeneOntologyBiologicalProcessprotein modification by small protein conjugation

TRIM45 RNF213 TRIM50 HERC2 RNF168 CNOT4 EPAS1

1.16e-04893277GO:0032446
GeneOntologyBiologicalProcessubiquitin-dependent protein catabolic process

TRIM45 RNF213 HERC2 RNF168 CNOT4 EPG5

1.48e-04640276GO:0006511
GeneOntologyBiologicalProcessmodification-dependent protein catabolic process

TRIM45 RNF213 HERC2 RNF168 CNOT4 EPG5

1.62e-04651276GO:0019941
GeneOntologyBiologicalProcessmodification-dependent macromolecule catabolic process

TRIM45 RNF213 HERC2 RNF168 CNOT4 EPG5

1.69e-04656276GO:0043632
GeneOntologyBiologicalProcessprotein modification by small protein conjugation or removal

TRIM45 RNF213 TRIM50 HERC2 RNF168 CNOT4 EPAS1

2.46e-041009277GO:0070647
GeneOntologyBiologicalProcessphotoreceptor cell differentiation

THRB MFRP EPG5

2.64e-0496273GO:0046530
GeneOntologyBiologicalProcesspost-translational protein modification

TRIM45 RNF213 TRIM50 HERC2 RNF168 CNOT4 EPAS1

3.61e-041074277GO:0043687
GeneOntologyBiologicalProcessprotein ubiquitination

TRIM45 RNF213 TRIM50 HERC2 RNF168 CNOT4

5.28e-04811276GO:0016567
GeneOntologyBiologicalProcessproteolysis involved in protein catabolic process

TRIM45 RNF213 HERC2 RNF168 CNOT4 EPG5

5.32e-04812276GO:0051603
MousePhenoabnormal retina cone cell morphology

THRB MFRP GUCY2D EPG5

8.32e-0677244MP:0001006
MousePhenoabnormal retina cone cell inner segment morphology

MFRP GUCY2D

2.82e-055242MP:0008448
MousePhenodecreased retina cone cell number

MFRP GUCY2D EPG5

3.06e-0536243MP:0008446
MousePhenoincreased hematocrit

FES C19orf81 AP4E1 EPAS1

5.29e-05123244MP:0002608
MousePhenoabnormal retina neuronal layer morphology

AP4E1 THRB MFRP EPAS1 GUCY2D EPG5

7.91e-05441246MP:0006069
MousePhenoabnormal retina layer morphology

AP4E1 THRB MFRP EPAS1 GUCY2D EPG5

1.65e-04504246MP:0003727
MousePhenoabnormal photoreceptor inner segment morphology

MFRP GUCY2D EPG5

2.07e-0468243MP:0003730
MousePhenodecreased sensory neuron number

THRB MFRP GUCY2D EPG5

2.36e-04181244MP:0000966
MousePhenodecreased retina photoreceptor cell number

MFRP GUCY2D EPG5

2.66e-0474243MP:0001327
MousePhenoabnormal retina photoreceptor morphology

THRB MFRP GUCY2D EPG5

3.86e-04206244MP:0001004
MousePhenoabnormal eye physiology

FES THRB MFRP EPAS1 GUCY2D EPG5

4.46e-04606246MP:0005253
MousePhenoabnormal retina photoreceptor layer morphology

THRB MFRP GUCY2D EPG5

4.54e-04215244MP:0003728
MousePhenoneuron degeneration

THRB HERC2 MFRP GUCY2D EPG5

4.57e-04391245MP:0003224
MousePhenoretina spots

MFRP GUCY2D

4.75e-0419242MP:0012671
MousePhenoabnormal hemoglobin content

FES AP4E1 THRB RNF168 EPAS1

5.55e-04408245MP:0005563
MousePhenoabnormal eye electrophysiology

THRB MFRP EPAS1 GUCY2D

5.67e-04228244MP:0005551
MousePhenoabnormal hematocrit

FES C19orf81 AP4E1 RNF168 EPAS1

6.00e-04415245MP:0002596
MousePhenoabnormal cone electrophysiology

THRB MFRP GUCY2D

6.08e-0498243MP:0004022
MousePhenoabnormal physiological neovascularization

RNF213 EPAS1

6.39e-0422242MP:0003710
MousePhenoretina photoreceptor degeneration

MFRP GUCY2D EPG5

8.73e-04111243MP:0008450
MousePhenoincreased hemoglobin content

FES AP4E1 EPAS1

9.20e-04113243MP:0005564
DomainZF_RING_2

TRIM45 RNF213 TRIM50 RNF168 CNOT4

7.27e-05298285PS50089
DomainRING

TRIM45 RNF213 TRIM50 RNF168 CNOT4

8.11e-05305285SM00184
DomainZnf_RING

TRIM45 RNF213 TRIM50 RNF168 CNOT4

1.11e-04326285IPR001841
DomainATPase_dyneun-rel_AAA

DNAH9 DNAH1

1.95e-0414282IPR011704
DomainDynein_heavy_chain_D4_dom

DNAH9 DNAH1

1.95e-0414282IPR024317
DomainDynein_HC_stalk

DNAH9 DNAH1

1.95e-0414282IPR024743
DomainDynein_heavy_dom-2

DNAH9 DNAH1

1.95e-0414282IPR013602
DomainDHC_N2

DNAH9 DNAH1

1.95e-0414282PF08393
DomainMT

DNAH9 DNAH1

1.95e-0414282PF12777
DomainAAA_8

DNAH9 DNAH1

1.95e-0414282PF12780
DomainAAA_5

DNAH9 DNAH1

1.95e-0414282PF07728
DomainDHC_fam

DNAH9 DNAH1

2.25e-0415282IPR026983
DomainDynein_heavy_dom

DNAH9 DNAH1

2.25e-0415282IPR004273
DomainDynein_heavy

DNAH9 DNAH1

2.25e-0415282PF03028
Domainzf-C3HC4

TRIM45 RNF213 TRIM50 RNF168

3.23e-04223284PF00097
Domain-

TRIM45 RNF213 TRIM50 RNF168 CNOT4

4.89e-044492853.30.40.10
DomainZnf_RING/FYVE/PHD

TRIM45 RNF213 TRIM50 RNF168 CNOT4

5.40e-04459285IPR013083
DomainZF_RING_1

TRIM45 TRIM50 RNF168 CNOT4

8.80e-04291284PS00518
DomainPkinase_Tyr

FES LTK GUCY2D

9.29e-04129283PF07714
DomainSer-Thr/Tyr_kinase_cat_dom

FES LTK GUCY2D

1.13e-03138283IPR001245
DomainZnf-RING_LisH

TRIM45 TRIM50

1.18e-0334282IPR027370
Domainzf-RING_UBOX

TRIM45 TRIM50

1.18e-0334282PF13445
DomainZnf_C3HC4_RING-type

RNF213 TRIM50 RNF168

2.12e-03172283IPR018957
DomainBBOX

TRIM45 TRIM50

4.78e-0369282SM00336
Domain-

TRIM45 TRIM50

5.05e-03712824.10.45.10
Domainzf-B_box

TRIM45 TRIM50

5.19e-0372282PF00643
DomainZF_BBOX

TRIM45 TRIM50

6.37e-0380282PS50119
DomainZnf_B-box

TRIM45 TRIM50

6.53e-0381282IPR000315
DomainCollagen

COL6A2 MFRP

7.17e-0385282PF01391
DomainCollagen

COL6A2 MFRP

7.17e-0385282IPR008160
DomainTyrKc

FES LTK

7.66e-0388282SM00219
DomainTyr_kinase_cat_dom

FES LTK

7.66e-0388282IPR020635
DomainPROTEIN_KINASE_TYR

FES LTK

9.24e-0397282PS00109
DomainTyr_kinase_AS

FES LTK

9.24e-0397282IPR008266
PathwayKEGG_MEDICUS_REFERENCE_DOUBLE_STRAND_BREAK_SIGNALING

HERC2 RNF168

1.96e-0413232M47832
Pubmed

DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger.

HERC2 RNF168

6.24e-06528222508508
Pubmed

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes.

HERC2 RNF168

9.36e-06628220023648
Pubmed

Interaction of the PAS B domain with HSP90 accelerates hypoxia-inducible factor-1alpha stabilization.

HSPA4 EPAS1

1.31e-05728215319539
Pubmed

CFAP43 modulates ciliary beating in mouse and Xenopus.

DNAH9 DNAH1

1.74e-05828231884020
Pubmed

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.

ADAMTS20 COL6A2 FBLN2

1.88e-056428322261194
Pubmed

Functional expression of the new gap junction gene connexin47 transcribed in mouse brain and spinal cord neurons.

GM2A HSPA4

2.24e-05928211160382
Pubmed

A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor.

FES HSPA4

2.80e-05102829222609
Pubmed

Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha.

HSPA4 EPAS1

3.42e-051128219940151
Pubmed

Biphasic expression of thyroid hormone receptor TRĪ²1 in mammalian retina and anterior ocular tissues.

THRB GUCY2D

5.65e-051428237033230
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

RNF213 HERC2 RNF168

6.16e-059528329643511
Pubmed

Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity.

THRB HSPA4

6.52e-051528217242407
Pubmed

Genetic mapping of mouse heat shock protein genes Hsc4a to chromosome 11 and Hsc74 to chromosome 18 and two Hsc74 pseudogenes to chromosomes X and 8.

GM2A HSPA4

6.52e-051528210087208
Pubmed

UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.

RNF213 HERC2

1.30e-042128237422473
Pubmed

Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis.

ADAMTS20 AKAP8

1.85e-042528229475039
Pubmed

Functional interactions between ubiquitin E2 enzymes and TRIM proteins.

TRIM45 TRIM50

2.17e-042728221143188
Pubmed

Lysine acetylation targets protein complexes and co-regulates major cellular functions.

RNF213 DENND4A

4.32e-043828219608861
Pubmed

Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins.

HERC2 HSPA4

5.03e-044128219343720
Pubmed

Multiple mouse chromosomal loci for dynein-based motility.

DNAH9 DNAH1

6.61e-04472828812413
Pubmed

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.

COL6A2 FBLN2

7.48e-045028224769233
Pubmed

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.

COL6A2 FBLN2

7.48e-045028223658023
InteractionUBE2D3 interactions

TRIM45 RNF213 TRIM50 LTK HERC2 RNF168 CNOT4

6.98e-08283277int:UBE2D3
InteractionUBE2D2 interactions

TRIM45 RNF213 TRIM50 HERC2 RNF168 CNOT4

3.30e-06318276int:UBE2D2
InteractionUBE2N interactions

RNF213 TRIM50 LTK HERC2 RNF168 CNOT4

5.81e-06351276int:UBE2N
InteractionUBE2D1 interactions

TRIM45 TRIM50 HERC2 RNF168 CNOT4

3.96e-05294275int:UBE2D1
InteractionCNOT1 interactions

THRB HERC2 FAM120C CNOT4 EPAS1

4.72e-05305275int:CNOT1
InteractionUBE2E1 interactions

TRIM45 TRIM50 RNF168 CNOT4

6.41e-05164274int:UBE2E1
InteractionDNAJB8 interactions

HERC2 AKAP8 HSPA4

1.64e-0480273int:DNAJB8
InteractionUBE2L3 interactions

RNF213 HERC2 RNF168 HSPA4

1.70e-04211274int:UBE2L3
GeneFamilyDyneins, axonemal

DNAH9 DNAH1

1.73e-0417212536
GeneFamilyRing finger proteins

TRIM45 RNF213 TRIM50 RNF168

2.56e-0427521458
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM45 TRIM50

5.38e-039521259
ToppCell10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-ILC3|lymph-node_spleen / Manually curated celltypes from each tissue

FES C19orf81 EPAS1 GUCY2D

6.07e-06192284e16035b3328f9b1b2e28d234c62ba88387540550
ToppCell(3)_ILC|World / shred on Cell_type and subtype

FES C19orf81 EPAS1 GUCY2D

7.14e-0620028403554b3f323785b1e0b48fa32de0d92065dd798e
ToppCell(30)_ILC|World / shred on Cell_type and subtype

FES C19orf81 EPAS1 GUCY2D

7.72e-06204284bd9fbd278c05e396463704d711b60d47699e3c09
ToppCell10x_3'_v3-blood_(10x_3'_v3)-hematologic-hematopoietic_progenitor-common_myeloid_progenitor|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

C19orf81 TRIM45 FBLN2

8.56e-051372836d90da42dcc06aa895f920218055068f3c76d57d
ToppCell367C-Lymphocytic-NK_cells-NK_cell_D|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

GM2A FAM120C CNOT4

1.08e-0414828310dcbdb47cac908648d9d652c8095b536db19b8a
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

FBLN2 FAM120C GUCY2D

1.19e-0415328391e9d70a5d3f6fd68c284ed0cc113f03d7d1e10b
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FBLN2 FAM120C GUCY2D

1.19e-04153283f17f62646633cf95c810dcd5328978058741b276
ToppCellsevere_COVID-19-MAIT|World / disease group, cell group and cell class (v2)

LTK FAM120C ADAT1

1.21e-0415428365ec7f7ef05c589903c4c9fe3849478c325fdc61
ToppCellMS-CD8-memory_CD4|MS / Condition, Cell_class and T cell subcluster

TRIM45 AP4E1 EPAS1

1.21e-04154283aec893cf3e1cf90e18a9117183fc7a1f397425a9
ToppCellsevere_COVID-19-MAIT|severe_COVID-19 / disease group, cell group and cell class (v2)

LTK FAM120C ADAT1

1.28e-04157283175f637e9707836bd63b5c2ccc9d4eb601c05b9e
ToppCellICU-NoSEP-Myeloid-tDC|ICU-NoSEP / Disease, Lineage and Cell Type

C19orf81 FBLN2 LTK

1.92e-04180283be665e801512f6aaf6b3ecb26153bbdeb24619ac
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS20 DNAH9 DNAH1

2.04e-04184283ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS20 DNAH9 DNAH1

2.04e-041842832cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS20 DNAH9 DNAH1

2.04e-041842832b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-ILC3|lymph-node_spleen / Manually curated celltypes from each tissue

C19orf81 EPAS1 GUCY2D

2.04e-04184283479e60f76c191253e23699c9dd7ef7efc08c59ad
ToppCellHealthy_donor-pDC|Healthy_donor / disease group, cell group and cell class (v2)

C19orf81 LTK GUCY2D

2.08e-041852837fbb55cbdb39bdecb6063c8ba9776ab06c2666e8
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

COL6A2 THRB HSPA4

2.14e-04187283cfdc1585c80d2bb475d9145395fb50a88c53f838
ToppCelldroplet-Lung-1m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL6A2 FBLN2 THRB

2.14e-04187283ed7ab4cf4629d96dad5c74d536fc428d0a8d4eb9
ToppCellHealthy_donor-pDC|World / disease group, cell group and cell class (v2)

C19orf81 LTK GUCY2D

2.14e-04187283aa2cc54487d3c5045ac0c93560944c5a55878e27
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

RNF213 DENND4A EPG5

2.18e-04188283ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FES FBLN2 EPAS1

2.18e-04188283c2c51c6526defe2600302901159b8abbb58d7595
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-Undetermined|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

C19orf81 COL6A2 FBLN2

2.18e-041882838231e635706a296db6b6da1029a33bbc1b52478e
ToppCell(6)_ILC|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

FES C19orf81 EPAS1

2.18e-04188283de7cb273899d0e0748c85f45c6b5e7f0642ab057
ToppCell(6)_ILC|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

FES C19orf81 EPAS1

2.18e-04188283f4734d5b703678670ece204a0519cf015e180a6e
ToppCell10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like|lymph-node_spleen / Manually curated celltypes from each tissue

FES LTK EPAS1

2.25e-041902830c7eb8f4f2926af01bf44d5c9f239be7b81c67fe
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

COL6A2 THRB HSPA4

2.32e-0419228397c312c82ec025c13052f8d424b11c0034c8ea54
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FES FBLN2 EPAS1

2.32e-041922833259cb89d6bcf0a3c6ff1f64d85e8a1f54124e91
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

COL6A2 THRB HSPA4

2.32e-041922833b0a52e4e77ae4539a034dcb419773b8e2aa5d51
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4|GI_small-bowel / Manually curated celltypes from each tissue

RNF213 LTK EPAS1

2.39e-041942834547b57669be5d4f0de55175802ee04372288a6a
ToppCellCOVID-19_Severe-CD8+_Tem|World / disease group, cell group and cell class

TDRD15 RNF213 COL6A2

2.39e-0419428360aa16e166894e3fcd82f7a54607c2c02e55b614
ToppCell3'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FES FBLN2 EPAS1

2.42e-04195283d46955155e5b22d00939eaf5edfb8ac217d06e46
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

RNF213 COL6A2 LTK

2.46e-04196283c06caba0c91b8ee66f42bc43ec75eb2475f07056
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RNF213 COL6A2 LTK

2.46e-04196283093fb240e72911dfd360aa6edf8ed2d611c78a1e
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A2 FBLN2 EPAS1

2.50e-041972836668f0da54f3bf96769275e668cd57e00b8a5ef9
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A2 FBLN2 EPAS1

2.50e-041972837c275a2ac24a9a4f83fceda93a067e754837102f
ToppCellnormal_Lymph_Node-Myeloid_cells-Undetermined|Myeloid_cells / Location, Cell class and cell subclass

GM2A COL6A2 EPAS1

2.50e-041972833ad72b70406e8a4c6996ec41809b174a423dad38
ToppCell(2)_NK/T-(22)_CD8+_T_cell|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)

COL6A2 FBLN2 LTK

2.50e-0419728320dad8e4ed36a0185e231ddcb327725d2b2005e0
ToppCellPCW_10-12|World / Celltypes from embryonic and fetal-stage human lung

DENND4A THRB CNOT4

2.50e-0419728347fd8b0d596c5db1a722473c8efbb17a6bbe7538
ToppCellmild_COVID-19_(asymptomatic)-NK|World / disease group, cell group and cell class (v2)

RNF213 COL6A2 EPG5

2.54e-041982837a0aac52d785037455e068e1b25de4b2bf0fff79
ToppCellmLN-ILC|mLN / Region, Cell class and subclass

FES EPAS1 GUCY2D

2.57e-04199283d6c299312c747fb1b7c53644c53efc03a5fffe85
ToppCellmLN-(3)_ILC|mLN / shred on region, Cell_type, and subtype

FES EPAS1 GUCY2D

2.57e-0419928300e0e2a766dd9c4d0a65f53d88fa50df4b6a3d60
ToppCelldistal-2-Endothelial-Artery|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FES FBLN2 EPAS1

2.57e-04199283fa8aaf7a90699e41a7a4cee5614f8c9248110327
ToppCellmLN-(3)_ILC-(30)_ILC|mLN / shred on region, Cell_type, and subtype

FES EPAS1 GUCY2D

2.57e-0419928333ac6d77099076df01299be429f4ba96f2f34cc1
ToppCellmLN-ILC-ILC|mLN / Region, Cell class and subclass

FES EPAS1 GUCY2D

2.57e-04199283ab09a06cdea2597e9fe4b4b304655e9de4d433f6
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuroepithelial|5w / Sample Type, Dataset, Time_group, and Cell type.

GM2A COL6A2 FBLN2

2.61e-0420028369707f9576d326a06faac49701ef5cd632e760f6
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuroepithelial-Proteoglycan-expressing_cell|5w / Sample Type, Dataset, Time_group, and Cell type.

GM2A COL6A2 FBLN2

2.61e-04200283f94381d0a3b5b81cdbb13b75fc0e4910cbd70382
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Six3-Pvalb_(Thalamic_reticular_nucleus_(TRN))-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

TRIM50 MFRP

5.84e-0457282ade0457d85acaf87fcbeb6ac0d81525bb4a96950
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Six3-Pvalb_(Thalamic_reticular_nucleus_(TRN))|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

TRIM50 MFRP

5.84e-04572820e92c8af66bfdf9de6410c82f404b65b1424e09c
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Six3-Pvalb_(Thalamic_reticular_nucleus_(TRN))--|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

TRIM50 MFRP

5.84e-045728200083b7c710affa6e24ed495ed46ec6fcea8b676
ToppCellfacs-Skin-Anagen-24m-Epithelial-inner_bulge|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C19orf81 HERC2

1.78e-0310028297ca9cda55a05fbb4d1f5d61f847c965e014f05c
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-matrix_-_immature_2|E16.5-samps / Age Group, Lineage, Cell class and subclass

ADAMTS20 FAM120C

2.26e-03113282dc002185095590fc071b2f39259f8b87a757e174
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

EPAS1 GUCY2D

2.59e-03121282e57b026794130aa69b67f6170bcd5093f885fdb1
ToppCellIonocyte-iono-4|World / Class top

LTK BRAT1

2.94e-0312928285ee6e16959cb58a58f5b09edf1f78d9ce6a9441
ToppCellPBMC-Mild-cDC_4|Mild / Compartment, Disease Groups and Clusters

FAM120C GUCY2D

3.12e-03133282e53fbd69775a4bff61de82557342f7ac80915c4d
ToppCellPBMC-Severe-Myeloid-Neutrophil-Neutrophil-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ADAMTS20 EPAS1

3.40e-03139282fa0eedebf53317928022c3bed391ce99a2114f98
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-like-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AP4E1 FBLN2

3.54e-031422825690eee2ce1ecd02e34eac4193578bd13c4228b9
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Neuroendocrine_Carcinoma-2|TCGA-Pancreas / Sample_Type by Project: Shred V9

C19orf81 DNAH9

3.74e-03146282bc2adef529d0bbfcccef7435401a47a6ffcc1832
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Neuroendocrine_Carcinoma|TCGA-Pancreas / Sample_Type by Project: Shred V9

C19orf81 DNAH9

3.74e-0314628272c1e7e0c2b6ff6c4084af61fa19c2b8eab16eda
ToppCellPND01-03-samps-Myeloid-Granulocyte|PND01-03-samps / Age Group, Lineage, Cell class and subclass

FES GM2A

3.89e-031492827bdb396de8a1ef27ab0c2aaf1452576f4b0b5561
ToppCellPND28|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

GM2A EPAS1

3.89e-03149282d3a025440c8ad284a9291c902403e5888d28e90b
ToppCellPND01-03-samps-Myeloid-Granulocyte-neutrophil__Lgals3-negative|PND01-03-samps / Age Group, Lineage, Cell class and subclass

FES GM2A

3.89e-0314928250f53018e525b3d252caa8bed9e075b1bb1086dd
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AP4E1 ADAT1

3.94e-0315028247ea08d7609e1d2382bf56ef9e5c767e3597cf93
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A2 FBLN2

4.05e-03152282d5ba87b5d34e52cef8475befafea962d70fa8a1d
ToppCelldroplet-Lung-30m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l14|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DENND4A BRAT1

4.05e-031522820fda8980b10ce16179dea92301db74d728f41794
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DENND4A GUCY2D

4.05e-0315228218194f757d319958f26e5a91f56d89f25711236f
ToppCelldroplet-Liver-LIVER_HEPATOCYTES|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A2 FBLN2

4.05e-03152282d88d68a788a3256671ebbc06e104833f1f58f07d
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Thalamus / BrainAtlas - Mouse McCarroll V32

COL6A2 FBLN2

4.10e-03153282e9c6fb5c41adb6595c66c3a917fe455348279e54
ToppCellPND01-03-samps-Epithelial-Epithelial-non_alveolar|PND01-03-samps / Age Group, Lineage, Cell class and subclass

LTK DNAH9

4.10e-03153282fc0d2d50aa3b6b2772bbf3626c9df5c5e8d7d11e
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Thalamus / BrainAtlas - Mouse McCarroll V32

COL6A2 FBLN2

4.10e-03153282b8b5ff7d2feea3e3a352fb5530e49f639fe1ff88
ToppCellPND01-03-samps-Epithelial-Epithelial-non_alveolar-Ciliated_cell_of_lung_parenchyma|PND01-03-samps / Age Group, Lineage, Cell class and subclass

LTK DNAH9

4.10e-031532822482247d9c39c7b99bb45fb9153442f64fd6012f
ToppCellLeuk-UTI-Lymphocyte-T_NK-MAIT|Leuk-UTI / Disease, Lineage and Cell Type

COL6A2 LTK

4.10e-03153282ac3a1d1b5bf6009df818fd757dad7382d95c60dc
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP|Thalamus / BrainAtlas - Mouse McCarroll V32

COL6A2 FBLN2

4.10e-031532822513edfae62a44e51d3556675a096723194c966c
ToppCell367C-Fibroblasts-Fibroblast-D-|367C / Donor, Lineage, Cell class and subclass (all cells)

COL6A2 FBLN2

4.15e-03154282dd3d34f065820e706515a13619f19a5b12734c8e
ToppCellCV-Healthy-3|Healthy / Virus stimulation, Condition and Cluster

DENND4A EPAS1

4.15e-0315428226bf81a86700db7e65c2384ffe94ed4253ea4047
ToppCell367C-Fibroblasts-Fibroblast-D|367C / Donor, Lineage, Cell class and subclass (all cells)

COL6A2 FBLN2

4.15e-031542824bfda1c41efbb86d829b3797d1168bf2587c3c97
ToppCellControl-Epithelial_airway-Ciliated_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH9 DNAH1

4.15e-031542827556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCellControl-Epithelial_airway-Ciliated_cells-Ciliated|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH9 DNAH1

4.15e-031542824e3bc24043144143842627cacf6f90dda2228910
ToppCellLPS_only-Epithelial_airway-Ciliated_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH9 DNAH1

4.15e-0315428258072ce422d09f2de602580325eaac6c4ec6c136
ToppCellLPS_only-Epithelial_airway-Ciliated_cells-Ciliated|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH9 DNAH1

4.15e-031542829ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH9 DNAH1

4.20e-031552825f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH9 DNAH1

4.20e-031552820944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCellnormal-na-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

COL6A2 ADAT1

4.20e-0315528208295584395e8d9cfc1b1648f98754b3ac53e587
ToppCellNS-moderate-d_07-13-Myeloid-Mast_cell|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

C19orf81 FBLN2

4.26e-0315628217c38d3b03fc38cb125cf0d165b2fd694cd88edd
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

RNF213 DENND4A

4.26e-031562821545169694f686d28648a68b552c2ae606599d66
ToppCellE15.5-Hematopoietic-Immune-immune_cell_unspecified|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FES GM2A

4.31e-031572824263627911657e788a1d0230690ee434e8a4f9a1
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EPAS1 EPG5

4.31e-031572822c946c6ab284fac3c25db688ed0aabe5a3f9ffa5
ToppCellE15.5-Hematopoietic-Immune|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FES GM2A

4.31e-03157282de689a133863ed74d848eba0a4f392357ac28245
ToppCelldroplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RNF168 BRAT1

4.31e-03157282a426c54fd1545093d41426e9620862f71bd06f6b
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LTK EPAS1

4.42e-03159282d3f81ba22160568ccaa6d2b04ebfd30630f9a6db
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-Natural_Killer_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THRB ADAT1

4.42e-031592827619d0d49738dd08daf01b42664691a5323aa793
ToppCellsevere_COVID-19-pDC|World / disease group, cell group and cell class (v2)

C19orf81 LTK

4.42e-03159282e1c48c4ceda116826819ff9adeed7bad6a58844d
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AP4E1 HSPA4

4.42e-03159282f7bccfeffa737f151417bf52ea45111b0957bce9
ToppCellIIF-Lymphocyte-T_NK-ILC|IIF / Disease, Lineage and Cell Type

C19orf81 DNAH1

4.42e-0315928255e4f21548f480ca414c00cbff5ec3b13bafd271
ToppCellPosterior_cortex|World / BrainAtlas - Mouse McCarroll V32

LTK THRB

4.42e-0315928218e9fe2efbe0bca7c3990f3b12b6f549e2c1263a
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-mature_NK_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THRB ADAT1

4.42e-031592824000ed0d3b7d488722bcd0042fa2ff4405aaab82
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH9 DNAH1

4.42e-0315928200a157d033627d0e65c3fbd38d652c4cf56b47f6
ToppCellsevere_COVID-19-pDC|severe_COVID-19 / disease group, cell group and cell class (v2)

C19orf81 LTK

4.42e-03159282ea5088d27e42b8850455764d53b757ea8d8f14bc
ToppCellCOVID-19_Moderate-MAIT|COVID-19_Moderate / disease group, cell group and cell class

COL6A2 LTK

4.42e-031592826d08d670c34eb6bb8ad5dad3293b3107c006236d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FES EPAS1

4.47e-03160282830e3ef8c9708d25872c3052a0b2682fa9372111
ToppCellNS-critical-d_16-33-Myeloid-Mast_cell|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

C19orf81 FBLN2

4.47e-03160282c61869d9dbba250270e59366e15af204e5b4395d
Diseasefetal genotype effect measurement, body weights and measures

FES HSPA4 EPAS1

1.22e-0549273EFO_0004324, EFO_0007959
Diseasecorneal resistance factor

ADAMTS20 COL6A2 FBLN2 HERC2 BRAT1

4.99e-05451275EFO_0010067
Diseasebody weights and measures, parental genotype effect measurement

FES EPAS1

7.29e-0514272EFO_0004324, EFO_0005939
Diseasehemoglobin measurement, mean corpuscular hemoglobin

DENND4A THRB

1.84e-0422272EFO_0004509, EFO_0004527
DiseasePolynesian Bronchiectasis

DNAH9 DNAH1

4.71e-0435272C4317124
DiseaseCiliary Dyskinesia, Primary, 1, With Or Without Situs Inversus

DNAH9 DNAH1

4.71e-0435272C4551906
DiseaseKartagener Syndrome

DNAH9 DNAH1

4.71e-0435272C0022521
Diseaseimmature reticulocyte measurement

DENND4A THRB

6.16e-0440272EFO_0803545
Diseaseretinitis pigmentosa (is_implicated_in)

MFRP GUCY2D

6.47e-0441272DOID:10584 (is_implicated_in)
DiseasePrimary Ciliary Dyskinesia

DNAH9 DNAH1

8.50e-0447272C4551720

Protein segments in the cluster

PeptideGeneStartEntry
EPLLSCLIIMCEPIQ

EPAS1

216

Q99814
LEPDEDILMPFNLFC

EPG5

1801

Q9HCE0
MDPECAQLLPALCAV

BRAT1

1

Q6PJG6
CLACDMLIPAQPQLL

AKAP8

481

O43823
CDPEVRPLMEQECSL

ADAMTS20

1246

P59510
SIIPMLEFEDQPCCP

ADAT1

146

Q9BUB4
FPCEMIPAVLPLIED

AP4E1

161

Q9UPM8
DPPDEVCYRILMQLC

DENND4A

806

Q7Z401
PPELACEPVQVEMCL

MFRP

461

Q9BY79
ASQPLCLCMETLPEE

C19orf81

76

C9J6K1
FLEMCNDLLARVEPP

HSPA4

306

P34932
LCRPLVSMDQAPVEC

GUCY2D

766

Q02846
LSELFCPCIPMFDLE

HERC2

4356

O95714
LPELCSPQDELDFLM

LTK

546

P29376
FMLCPELPPNCIEAV

FBLN2

111

P98095
VPRIQLLFCAEDPCM

DNAH1

356

Q9P2D7
MEDVLCPDPQIVCPD

COL6A2

801

P12110
PVCIEDECNMELPPA

FAM120C

636

Q9NX05
RPCAMVVPDFELICE

DNAH9

1991

Q9NYC9
CPELCPDAVFRLMEQ

FES

781

P07332
FCDVLDMLIPTGEPC

GM2A

111

P17900
GILCPVCDAQVDLPM

TRIM45

91

Q9H8W5
ILLPEFCELPALAMC

TDRD15

581

B5MCY1
PVECPLCMEPLEIDD

CNOT4

11

O95628
MRCLPAFLPDCLDLE

RNF213

1786

Q63HN8
PMFCELPCEDQIILL

THRB

291

P10828
CGICMEILVEPVTLP

RNF168

16

Q8IYW5
CPICLEVFKEPLMLQ

TRIM50

16

Q86XT4