Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainTLV_coat

ERVV-1 ERVV-2

2.52e-057212PF00429
DomainTLV/ENV_coat_polyprotein

ERVV-1 ERVV-2

3.36e-058212IPR018154
DomainLIM

MICALL1 LPP

2.70e-0369212PF00412
Domain-

MICALL1 LPP

2.78e-03702122.10.110.10
DomainLIM_DOMAIN_2

MICALL1 LPP

2.86e-0371212PS50023
DomainZnf_LIM

MICALL1 LPP

2.86e-0371212IPR001781
DomainLIM_DOMAIN_1

MICALL1 LPP

2.86e-0371212PS00478
DomainLIM

MICALL1 LPP

2.86e-0371212SM00132
Domain-

ABI3BP NFATC3 ROBO1 IGSF1

5.82e-036632142.60.40.10
DomainIg-like_fold

ABI3BP NFATC3 ROBO1 IGSF1

7.25e-03706214IPR013783
Domainfn3

ABI3BP ROBO1

1.41e-02162212PF00041
DomainSH3_1

CACNB1 TP53BP2

1.44e-02164212PF00018
DomainFN3

ABI3BP ROBO1

1.81e-02185212SM00060
DomainFN3

ABI3BP ROBO1

2.08e-02199212PS50853
DomainFN3_dom

ABI3BP ROBO1

2.28e-02209212IPR003961
DomainSH3

CACNB1 TP53BP2

2.42e-02216212PS50002
DomainSH3

CACNB1 TP53BP2

2.42e-02216212SM00326
DomainSH3_domain

CACNB1 TP53BP2

2.50e-02220212IPR001452
DomainIg_sub2

ROBO1 IGSF1

2.83e-02235212IPR003598
DomainIGc2

ROBO1 IGSF1

2.83e-02235212SM00408
Pubmed

Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation.

ERVV-1 ERVV-2

4.18e-07223223555306
Pubmed

Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution.

ERVV-1 ERVV-2

4.18e-07223218826608
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

SRRM2 AFF4 MCM3AP GSE1 GTF3C1

2.56e-0634123532971831
Pubmed

Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets.

ERVV-1 ERVV-2

6.26e-06623223085571
Pubmed

Syncytins expressed in human placental trophoblast.

ERVV-1 ERVV-2

1.17e-05823233504453
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

MICALL1 SRRM2 NFATC3 DIP2B TP53BP2 LPP

1.59e-0586123636931259
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

MCM3AP IGSF1 MCF2L2

8.56e-0513023312421765
Pubmed

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

SRRM2 TP53BP2 LPP

9.15e-0513323315144186
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

MICALL1 SRRM2 DIP2B GSE1 GTF3C1

1.30e-0477423515302935
Pubmed

Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.

ABI3BP SRRM2 AFF4

1.47e-0415623322952844
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

C15orf39 TP53BP2 GSE1 GTF3C1

1.52e-0441823434709266
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

C15orf39 MCM3AP GSE1

2.24e-0418023335198878
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

ROBO1 TP53BP2 LPP

3.47e-0420923336779422
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

NFATC3 DIP2B CACNB1 AFF4 TP53BP2

3.58e-0496323528671696
Pubmed

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

DIP2B TP53BP2 LPP

3.92e-0421823333378226
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

SRRM2 ROBO1 TP53BP2 LPP GSE1

5.29e-04104923527880917
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

NFATC3 C15orf39 MCM3AP GSE1

5.55e-0458823438580884
Pubmed

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.

MICALL1 SRRM2 TP53BP2

6.19e-0425523315324660
CytobandEnsembl 112 genes in cytogenetic band chr3q27

LPP MCF2L2

1.88e-03128232chr3q27
CytobandEnsembl 112 genes in cytogenetic band chr16q24

GAS8-AS1 GSE1

2.12e-03136232chr16q24
GeneFamilyLIM domain containing

MICALL1 LPP

7.98e-04591321218
GeneFamilyFibronectin type III domain containing

ABI3BP ROBO1

5.69e-03160132555
DrugVerteporfin [129497-78-5]; Down 200; 2.8uM; MCF7; HT_HG-U133A

ROBO1 MCM3AP LPP IGSF1

1.13e-051552146817_DN
DrugChelidonine monohydrate (+) [476-32-4]; Up 200; 10.8uM; MCF7; HT_HG-U133A

MICALL1 NFATC3 MCM3AP LPP

2.57e-051912146236_UP
DrugLY 294002; Down 200; 10uM; MCF7; HT_HG-U133A

MICALL1 C15orf39 ROBO1 MCM3AP

2.62e-051922145596_DN
DrugTocopherol (R,S) [10191-41-0]; Down 200; 9.2uM; MCF7; HT_HG-U133A

SRRM2 C15orf39 MCM3AP IGSF1

2.79e-051952144961_DN
DrugIopamidol [60166-93-0]; Down 200; 5.2uM; MCF7; HT_HG-U133A

ABI3BP SRRM2 C15orf39 IGSF1

2.90e-051972143473_DN
Drugaspirin, USP; Down 200; 100uM; MCF7; HT_HG-U133A

MICALL1 C15orf39 ROBO1 MCM3AP

2.90e-051972145564_DN
DrugCalycanthine [595-05-1]; Up 200; 11.6uM; MCF7; HT_HG-U133A

MICALL1 ABI3BP CACNB1 MCM3AP

2.90e-051972146221_UP
DrugPicrotoxinin [17617-45-7]; Down 200; 13.6uM; MCF7; HT_HG-U133A

NFATC3 C15orf39 AFF4 MCM3AP

2.96e-051982142816_DN
DrugOxybutynin chloride [1508-65-2]; Up 200; 10.2uM; PC3; HT_HG-U133A

SRRM2 CACNB1 MCM3AP LPP

2.96e-051982147126_UP
Diseaseautosomal dominant intellectual developmental disorder (is_implicated_in)

SRRM2 DIP2B

6.52e-0517212DOID:0060307 (is_implicated_in)
Diseasealopecia areata

LPP GSE1

5.79e-0450212EFO_0004192
DiseaseColorectal Carcinoma

CACNB1 MCM3AP MCF2L2 GSE1

1.38e-03702214C0009402
Diseasecarotid plaque build

ABI3BP ROBO1

1.62e-0384212EFO_0006501
Diseasemosquito bite reaction itch intensity measurement

AFF4 LPP

3.77e-03129212EFO_0008377
DiseaseMalignant neoplasm of breast

MICALL1 ROBO1 TP53BP2 MCF2L2

6.37e-031074214C0006142
Diseasebody fat distribution

DIP2B B4GALNT3

8.99e-03202212EFO_0004341
Diseaseurate measurement, bone density

ROBO1 LPP GSE1

9.22e-03619213EFO_0003923, EFO_0004531

Protein segments in the cluster

PeptideGeneStartEntry
EAYWKATHPPSSTPP

CACNB1

406

Q02641
SPHSDKWPPGHPVKN

B4GALNT3

526

Q6L9W6
PVPLSHSTNGKSKPW

GSE1

1001

Q14687
PKAHTVPTWPKSTVP

ERVV-2

201

B6SEH9
TKGSKIHPVGPDWSP

TP53BP2

401

Q13625
SWPPPLTAIHTPCKT

AFF4

326

Q9UHB7
WKSKSPSPVHGAGPS

MCM3AP

1721

O60318
PKAHTVPTWPKSTVP

ERVV-1

201

B6SEH8
PVAPHPESSPKWVSS

MCF2L2

536

Q86YR7
SKPPKDWQPHISPAG

DIP2B

496

Q9P265
MSHPSWLPPKSTGEP

LPP

1

Q93052
HPWYGITPTSSPKTK

MICALL1

461

Q8N3F8
QHSQTPSPPAKKPWS

PATL2

166

C9JE40
DKPPKPSLSAWPSTV

IGSF1

416

Q8N6C5
VTDKPPKPSLSAWPS

IGSF1

1156

Q8N6C5
SSSSPHPKVKSGTPP

SRRM2

836

Q9UQ35
HPSPPAWTLKKPSES

GAS8-AS1

16

O95177
PTWGHKSSRPDQPSP

C15orf39

1021

Q6ZRI6
WPKSPPSTTALRPHS

C10orf67

361

Q8IYJ2
PWTPSPKHSGKTTPD

TICRR

1666

Q7Z2Z1
PSPFTWSKPKPGHTP

NFATC3

396

Q12968
GHPEPTISWKKDGSP

ROBO1

196

Q9Y6N7
TPKISKSPEPTWTTP

ABI3BP

486

Q7Z7G0
KSPEPTWTTPAPGKT

ABI3BP

491

Q7Z7G0
PKTQPHHSTPTKGGW

GTF3C1

506

Q12789